CN105288535A - Hemorrhoids ointment for treating hemorrhoids with syndrome of spleen deficiency and Qi collapse - Google Patents
Hemorrhoids ointment for treating hemorrhoids with syndrome of spleen deficiency and Qi collapse Download PDFInfo
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Abstract
The invention discloses a hemorrhoids ointment for treating hemorrhoids with a syndrome of spleen deficiency and Qi collapse. The hemorrhoids ointment is filled in capsules at two ends of a suppository. Active pharmaceutical ingredients of the hemorrhoids ointment include 40-60g of rhizoma zingiberis, 40-60g of fructus tsaoko, 40-60g of flos sophorae, 40-60g of radix sanguisorbae, 25-40g of clove, 25-40g of fructus evodiae, 25-40g of poria cocos, 25-40g of fructus aurantii, 25-40g of rhizoma cimicifugae dahuricae, 25-40g of radix scrophulariae, 25-40g of fructus foeniculi, 25-40g of pericarpium citri reticulatae, 25-40g of ramulus cinnamomi, 25-40g of rhizoma alismatis, 10-20g of mulberry, 10-20g of fructus perillae, 10-20g of semen platycladi, 10-20g of raw radix polygoni multiflori, 10-20g of herba centellae, 10-20g of fructus toosendan, 10-20g of flos celosiae cristatae and 10-15g of flos chrysanthemi. The middle of the suppository is slender gradually, an inner anus dosing head externally wraps the capsule on one side of the suppository, an outer anus dosing head internally wraps the capsule on the other side of the suppository, a plurality of dosing holes are integrally formed in walls of the inner anus dosing head and the outer anus dosing head and communicated with the corresponding capsules, the front end of the inner anus dosing head is integrally provided with an expansion wing, and a soft plastic layer is formed between the expansion wing and the outer wall of the corresponding capsule. The hemorrhoids ointment is simple in proportion, convenient to use, quick in action and effective in external use for hemorrhoids with the syndrome of spleen deficiency and Qi collapse.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of ZHICHUANG GAO for sinking of QI due to deficiency of the spleen type.
Background technology
Hemorrhoid (being commonly called as hemorrhoid) are a kind of common diseases being positioned at anus position, and any age all can fall ill, but with age, sickness rate increases gradually.Hemorrhoid are divided into internal hemorrhoid, external hemorrhoid, mixed hemorrhoid by the difference of happening part.A jagged visible line is had anal canal pectinate line in the junction of anal canal skin and rectal mucosa.Is internal hemorrhoid more than pectinate line, the supporting structure of anus pad, venous plexus and arteriovenous anastomosis Zhi Fasheng pathological change or displacement, coating rectal mucosa, because internal sphincter shrinks, anus pad is divided into left side, forward right side, right lateral side three pieces with Y type ditch, and therefore internal hemorrhoid is common in left side, forward right side and right lateral side; Be external hemorrhoid below pectinate line, coating anal canal mucosa, can be divided into connective tissue external hemorrhoid, varicose external hemorrhoid, thrombosed external hemorrhoid; What have internal hemorrhoid and external hemorrhoid concurrently is mixed hemorrhoid, is that internal hemorrhoid is merged by venous plexus and corresponding external hemorrhoid, and namely upper and lower venous plexus is identical, and mixed hemorrhoid is deviate from outside anus, during in plum blossom-shaped, is called annular hemorrhoid, if by sphincter incarceration, and formation strangulated hemorrhoid.Ancient times advocate " heat-clearing and toxic substances removing, cooling blood and dissolving stasis to Zhiduo County in hemorrhoid." Song dynasty Dou Han minister in ancient times says in " skin infection experience pandect ": " and with all hemorrhoid, all kinds of difference ... more than half based on removing heat from blood, slowly get effect." the Yuan Dynasty Zhu Zhenheng advocate " hemorrhoid are specially based on removing heat from blood " (" danxi's experiential therapy ").Liu Yuansu calls: " burnt when rushing down three, intimately move back, gold is brought about the desired sensation and breaks through wood, the restricted then five worm not lifes of wood, hemorrhoid have more " (" interchannel medical science, hemorrhoid opinion ").Dong Yuan, son and also think there is fire, has heat.Treatment is used acupuncture and moxibusion, ledebouriellae and Gentianae Macrophyllae Decoction, pain relieving as refreshing soup etc., main with heat clearing and blood cooling, dehumidifying blood stasis dispelling.These method for the treatment of in clinical, determined curative effect.But have because of wind, wet, dry, hot and patient clinically; There is deficiency of both QI and blood, spleen, lung, to suffer from a deficiency of the kidney and patient; There is simulataneous insufficiency and excessive person.So just should treat with card in treatment, should righting, eliminating evil again.Chinese traditional treatment hemorrhoid are emphasize the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, select suitable prescriptions of Chinese medicine exactly according to the body constitution of patient and symptom.The qi-regulating Chinese medicine of the Chinese medicine (as: Radix Et Rhizoma Rhei, Radix Rehmanniae, pockmarks core etc.) that the traditional Chinese medical science improves the blood-activating and stasis-removing (as: Radix Angelicae Sinensis, Flos Carthami) of blood circulation effect by tool usually to the treatment of hemorrhoid, the heat clearing and damp drying of the clear scorching effect of tool hankers medicine (as: Cortex Phellodendri, Radix Scutellariae), the Chinese medicine (Fructus Sophorae, Radix Sanguisorbae) of tool anastalsis, tool soften and lubricate stool effect, the effect of tool promotion intestinal peristalsis promoting (as; Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis) and lenitive Chinese medicine (as: Radix Paeoniae, Radix Glycyrrhizae) formed.This omnipotent side's effect is not omnipotent, if not to type, then produces little effect.
Hemorrhoid are caused a disease because being divided into several type by modern Chinese medicine: as, wind hinders intestinal network, damp invasion of lower energizer, qi depression to blood stasis, sinking of QI due to deficiency of the spleen, deficiency of YIN dryness of the intestine etc., and causing a disease because of difference, then method for making is different.
For the hemorrhoid of sinking of QI due to deficiency of the spleen type, patient: blood stasis is deviate from, not easily resets, anus bearing down, and color of having blood in stool is light, accompanies lazy speech of breathing hard, indigestion and loss of appetite loose stool, spiritlessness and weakness, lusterless complexion.Pale tongue, white and thin fur, thready and weak pulse or onion.Method for the treatment of: invigorating the spleen and replenishing QI, Gu de-hemostasis.Decoction of the prior art.Fang Xie: Radix Astragali invigorating the spleen and replenishing QI in side, yang invigorating consolidating superficial resistance; Radix Codonopsis, Bai Intraoperative, the sweet temperature QI invigorating of Radix Glycyrrhizae Preparata; Insufficiency of the spleen then transporting mistake department, easily causes the stagnation of QI, therefore stagnant by regulating the flow of vital energy of Pericarpium Citri Reticulatae; The collaborative ginseng of Rhizoma Cimicifugae, Radix Bupleuri, over sixty years of age are positive clearly with elevate a turnable ladder, and being so incensed that of making to sink promotes; Blood is born in gas, and the deficiency of vital energy then blood is weak, therefore with Chinese angelica blood supplementing and battalion; Halloysitum Rubrum relieving diarrhea with astringent stops blooding.All medicines share, and have invigorating the spleen and replenishing QI, the effect of the admittedly de-hemostasis of yang invigorating.But oral result is slow.In view of this technical problem, need to occur that a kind of proportioning is simple, easy to use, for sinking of QI due to deficiency of the spleen type hemorrhoid, the effective fireballing a kind of ZHICHUANG GAO for sinking of QI due to deficiency of the spleen type of external.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of proportioning simple, easy to use, for sinking of QI due to deficiency of the spleen type hemorrhoid, and the effective fireballing a kind of ZHICHUANG GAO for sinking of QI due to deficiency of the spleen type of external.
For solving this object, the invention discloses a kind of ZHICHUANG GAO for sinking of QI due to deficiency of the spleen type, comprise cap, the two ends of cap are provided with medicine bag, medicine bag is built with ZHICHUANG GAO, wherein, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 40-60g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 25-40g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 10-20g of Flos Celosiae Cristatae, Flos Chrysanthemi 10-15g;
The middle part of cap is gradually thin, the outer wrap of the medicine bag of cap side has administration head in anus, anus external administration head is enclosed with in the medicine bag of the opposite side of cap, administration head in anus, integratedly on the wall of anus external administration head be provided with some dosing holes, be connected between dosing holes and corresponding medicine bag, in anus, the front end of administration head is integrated is provided with the expansion wing, launch to be provided with soft plastic layer between the wing and medicine bag outer wall, the end of anus external administration head is integrated is provided with shrouding, shrouding is ellipticity, administration head in anus, anus external administration head is rubber, administration head in anus, be adhesively fixed between anus external administration head and cap.
Further, capsule built with 10-20g ointment.
The medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 40-50g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 25-30g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 10-15g of Flos Celosiae Cristatae, Flos Chrysanthemi 10-12g.
The medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 50-60g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 30-40g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 15-20g of Flos Celosiae Cristatae, Flos Chrysanthemi 12-15g.
In order to better realize the object of the invention, the present invention has the preparation method of the ZHICHUANG GAO disclosed for sinking of QI due to deficiency of the spleen type, as follows:
A, be prepared as plaster:
By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected; Extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster;
B, plaster is loaded on and wants in capsule and medicine bag, medicine bag is soft plastic product, in anus, administration head, anus external administration head are inner hollow and the ellipsoid shape rubber of one end open, medicine bag to be filled in respectively in anus in administration head and anus external administration head, in anus, the opening part of administration head, anus external administration head is adhesively fixed the both sides of cap
The shrouding of C, anus external administration head is plugged and connected with pricker; Administration head, the overall plastic sealing pack of anus external administration head in cap and anus.
Ointment of the present invention, with warming the spleen supporing yang to medicine Rhizoma Zingiberis, Fructus Tsaoko, what bowel relieving was stopped blooding is monarch drug to medicine Flos Sophorae, Radix Sanguisorbae, with warming middle-JIAO to relieve pain to medicine Flos Caryophylli, Fructus Evodiae, spleen invigorating circulation of qi promoting to medicine Poria, Fructus Aurantii, the removing toxic substances of clear spleen to medicine Rhizoma Cimicifugae, Radix Scrophulariae, temperature intestinal circulation of qi promoting to medicine Fructus Foeniculi, Pericarpium Citri Reticulatae, warming YANG activating QI be ministerial drug to medicine Ramulus Cinnamomi, Rhizoma Alismatis, with the Fructus Mori of intestine moistening, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, the Herba Centellae of removing toxic substances and promoting subsidence of swelling, the Fructus Toosendan of promoting the circulation of QI to relieve pain, the Flos Celosiae Cristatae of hemostasis is adjuvant drug, and Flos Chrysanthemi is for making medicine.
Proportioning of the present invention is simple, and easy to use, for sinking of QI due to deficiency of the spleen type hemorrhoid, the effective speed of external is fast.When the present invention uses, after tearing plastic sealing pack, pricker is pulled up from shrouding, thrust successively along multiple dosing holes, medicine bag is punctured, then patient lies prone in bed, administration head in anus is inserted along anus place, in insertion process, due to extruding and the sphincteral extruding of hands, ointment in medicine bag is constantly flowed out along dosing holes, and, in insertion process, the expansion wing and soft plastic layer make it possess elasticity, along with the insertion of administration head in anus, the expansion wing scrapes the feces in large intestine inwall and fold, enable the ointment of administration head in anus directly contact intestinal wall as far as possible, be convenient to the administration of internal hemorrhoid on the one hand, another is conveniently also beneficial to partially absorbing of intestinal, increase blood drug level.The ointment that anus external administration head is extruded, is beneficial to the coating of external hemorrhoid.The mode of this inside and outside directly administration of the present invention, except being directly administered into focus, can also partly by intestinal absorption, therapeutic effect is good, and responding time is fast.
Accompanying drawing illustrates:
Fig. 1 is structural representation of the present invention.
Fig. 2 is Fig. 1 side-looking direction schematic diagram.
Detailed description of the invention
As Figure 1-Figure 2, Fig. 1 is structural representation of the present invention.Fig. 2 is Fig. 1 side-looking direction schematic diagram.
The present invention is used for the ZHICHUANG GAO of sinking of QI due to deficiency of the spleen type, comprise cap 5, the two ends of cap 5 are provided with medicine bag 7, medicine bag 7 is built with ZHICHUANG GAO, wherein, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 40-60g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 25-40g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 10-20g of Flos Celosiae Cristatae, Flos Chrysanthemi 10-15g;
The middle part of cap 5 is gradually thin, the outer wrap of the medicine bag 7 of cap 5 side to have in anus administration 3, anus external administration head 6 is enclosed with in the medicine bag 7 of the opposite side of cap 5, administration 3 in anus, integratedly on the wall of anus external administration head 6 be provided with some dosing holes 4, be connected between dosing holes 4 and corresponding medicine bag 7, in anus, integrated being provided with in the front end of administration 3 launches the wing 1, launch to be provided with soft plastic layer 2 between the wing 1 and medicine bag 7 outer wall, the end of anus external administration head 6 is integrated is provided with shrouding 8, shrouding 8 is ellipticity, administration 3 in anus, anus external administration head 6 is rubber, administration 3 in anus, be adhesively fixed between anus external administration head 6 and cap.
Further, capsule built with 10-20g ointment.
Or, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 40-50g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 25-30g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 10-15g of Flos Celosiae Cristatae, Flos Chrysanthemi 10-12g.
Or, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 50-60g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 30-40g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 15-20g of Flos Celosiae Cristatae, Flos Chrysanthemi 12-15g.
For the ZHICHUANG GAO of sinking of QI due to deficiency of the spleen type, it is characterized in that, preparation method is as follows:
A, be prepared as plaster:
By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected; Extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster;
B, plaster is loaded on and wants in capsule and medicine bag, medicine bag is soft plastic product, in anus, administration head, anus external administration head are inner hollow and the ellipsoid shape rubber of one end open, medicine bag to be filled in respectively in anus in administration head and anus external administration head, in anus, the opening part of administration head, anus external administration head is adhesively fixed the both sides of cap
The shrouding of C, anus external administration head is plugged and connected with pricker; Administration head, the overall plastic sealing pack of anus external administration head in cap and anus.
Comparative test:
Modling model, gets 50 rats, male and female half and half, medicine of promoting the sexual maturity of throwing something and feeding, make its copulation, and every day reduces feeding volume day by day.After 5 days, after rat anesthesia, anal downward rectal mucosa seromuscular layer injects 1% carrageenin 0.1mL, respectively at 6,24,48,72,96h compasses measure the diameter of whole perianal tissue swelling, get the average of long and short two diameter, as the index of measured swelling degree, anus place swelling and deviating from after 6 days again, and there is proctoptosis symptom, abdominal part rises by drum, anus has blood and slack few dynamic.Histological indications shows: have a large amount of single-column columnar epithelium cell detachment, the visible pus stove of mucosa is formed, body of gland goblet cell reduces, a large amount of neutrophil infiltration and ulcer a large amount of or in blocks between body of gland, also significantly swelling around serous coat under mucosa, normal mucosa wrinkle wall disappears, and mucosal epithelial cells activity reduces, vasodilation under sticking to mould, and have leukocyte and fibrin to infiltrate.Observe rat, find rat have blood in stool, color is scarlet, measures more, anus swell beyond the region of objective existence take off, emersion object transudate is more, mucosal erosion, burning sensation of the anus.Sinking of QI due to deficiency of the spleen model forming.
Get 40 in 50 rat models, be divided into four groups at random, first group uses the present invention, make the cap of the present invention of ting model, smear ointment of the present invention inside and outside anus simultaneously, be preferably (Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 50g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 30g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 15g of Flos Celosiae Cristatae, Flos Chrysanthemi 12g.By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected; Extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster; )
Second group uses the general prescription of background technology: the qi-regulating Chinese medicine of the Chinese medicine (as: Radix Et Rhizoma Rhei, Radix Rehmanniae, pockmarks core etc.) that the heat clearing and damp drying of the clear scorching effect of (as: Radix Angelicae Sinensis, Flos Carthami), tool hankers medicine (as: Cortex Phellodendri, Radix Scutellariae), the Chinese medicine (Fructus Sophorae, Radix Sanguisorbae) of tool anastalsis, tool soften and lubricate stool effect, the effect of tool promotion intestinal peristalsis promoting (as; Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis) and lenitive Chinese medicine (as: Radix Paeoniae, Radix Glycyrrhizae) formed.Decoct as decoction, every day feeding three times, each 5ml.
3rd group uses the general prescription of background technology: the qi-regulating Chinese medicine of the Chinese medicine (as: Radix Et Rhizoma Rhei, Radix Rehmanniae, pockmarks core etc.) that the heat clearing and damp drying of the clear scorching effect of (as: Radix Angelicae Sinensis, Flos Carthami), tool hankers medicine (as: Cortex Phellodendri, Radix Scutellariae), the Chinese medicine (Fructus Sophorae, Radix Sanguisorbae) of tool anastalsis, tool soften and lubricate stool effect, the effect of tool promotion intestinal peristalsis promoting (as; Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis) and lenitive Chinese medicine (as: Radix Paeoniae, Radix Glycyrrhizae) formed.According to preparation method preparation of the present invention in ointment, smear in anus, outside anus simultaneously.
4th group uses the decoction oral in background technology, as: acupuncture and moxibusion.Fang Xie: with Radix Rehmanniae, Radix Angelicae Sinensis, Radix Paeoniae Rubra removing heat from blood and blood in side; Radix Scutellariae, Rhizoma Coptidis, Radix Trichosanthis clearing away heat-fire; Radix Sanguisorbae, the Fructus Sophorae can the fire of clear large intestine and cooling blood for hemostasis, are equipped with Rhizoma Cimicifugae, Radix Glycyrrhizae etc. with heat-clearing and toxic substances removing; Herba Schizonepetae expelling pathogenic wind from the body surface, cooling blood for hemostasis.Decoct as decoction, every day feeding three times, each 5ml.
Above-mentioned four groups of administrations are after 10 days
| group | symptom | rectum is cut into slices |
| first group | proctoptosis is retracted, and only, mucosa wrinkle wall recovers normal, mucosal epithelial cells activation recovering to blood.Action is replied as usual. | epithelial cell, the numerical value of body of gland goblet cell is within normal range, and neutrophil is even infiltration. |
| second group | intumescence has outer de-, and with transudate, blood does not stop.Action is replied as usual. | mucosa is rotten to the corn as seen, and goblet cell reduces, and a large amount of neutrophil infiltration, intercellular substance comes off. |
| 3rd group | blood only, do not retract, and mucosal epithelium still has ulcer by proctoptosis, and action is slack. | accidental neutrophil infiltration between body of gland, Interstitial edema, goblet cell reduces, and ulcer is few. |
| 4th group | intumescence has outer de-, with mucosal erosion, and with transudate.Action is slack. | mucosa is rotten to the corn as seen, and goblet cell reduces, and a large amount of neutrophil infiltration, intercellular substance comes off. |
By upper table comparison, can find, just use direct administration for first group, the 3rd group, effective directly to medicinal medicine for focus, but the 3rd group of therapeutic effect is not enough.To first group, second group, the 3rd group these three groups are carried out blood examination discovery upon administration half an hour:
The blood of first group, second group all detects, alkaloids active component, glycoside active component, terpenoid active component, lactone active component, alcohol, aldehyde and ketone active component, organic acid active component, phenolic active components.But the numerical value of first group is between the 1/2-3/5 of second group of numerical value, that is, blood drug level is not as second group.And the blood examination of the 3rd group, only detected alkaloids active component, glycoside active component, terpenoid active component, lactone active component, alcohol, organic acid active component, and blood drug level is the 1/8-1/5 of second group of numerical value.Can infer, launch the wing and scraped by the fold of one section of rectal wall, be blocked in by feces and launch outside the wing, what improve injury and intestinal absorbs situation, and ointment of the present invention is more direct for such hemorrhoid effect.
Object lesson 1
Remaining certain, dizzy dizzy, weak breath is weak, chronic diarrhea chronic dysentery, abdominal part falling inflation, proctoptosis, and tinnitus is tired, breathes hard, and conscious gas bearing down, has blood in stool, and emersion object has swelling sense, and companion breathes hard lazy speech, indigestion and loss of appetite loose stool, spiritlessness and weakness, lusterless complexion.Pale tongue, thready and weak pulse.
Use the present invention: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 50g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 30g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 15g of Flos Celosiae Cristatae, Flos Chrysanthemi 12g.By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected, extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster, during use, after tearing plastic sealing pack, pricker is pulled up from shrouding, thrust successively along multiple dosing holes, medicine bag is punctured, then patient lies prone in bed, administration head in anus is inserted along anus place, in insertion process, due to extruding and the sphincteral extruding of hands, ointment in medicine bag is constantly flowed out along dosing holes, and, in insertion process, the expansion wing and soft plastic layer make it possess elasticity, along with the insertion of administration head in anus, the expansion wing scrapes the feces in large intestine inwall and fold, enable the ointment of administration head in anus directly contact intestinal wall as far as possible, be convenient to the administration of internal hemorrhoid on the one hand, another is conveniently also beneficial to partially absorbing of intestinal, increase blood drug level.The ointment that anus external administration head is extruded, is beneficial to the coating of external hemorrhoid.The present invention once a day, each half an hour, after being used in conjunction 10 days, replys as usual.
Example 2
Blue certain, dizzy dizzy, weak breath is weak, chronic diarrhea chronic dysentery, abdominal part falling inflation, proctoptosis, and tinnitus is tired, breathes hard, and conscious gas bearing down, has blood in stool, and emersion object has swelling sense, and companion breathes hard lazy speech, indigestion and loss of appetite loose stool, spiritlessness and weakness, lusterless complexion, white and thin fur, thready and weak pulse.
Use the present invention: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 45g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 35g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 16g of Flos Celosiae Cristatae, Flos Chrysanthemi 12g.By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected, extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster, during use, after tearing plastic sealing pack, pricker is pulled up from shrouding, thrust successively along multiple dosing holes, medicine bag is punctured, then patient lies prone in bed, administration head in anus is inserted along anus place, in insertion process, due to extruding and the sphincteral extruding of hands, ointment in medicine bag is constantly flowed out along dosing holes, and, in insertion process, the expansion wing and soft plastic layer make it possess elasticity, along with the insertion of administration head in anus, the expansion wing scrapes the feces in large intestine inwall and fold, enable the ointment of administration head in anus directly contact intestinal wall as far as possible, be convenient to the administration of internal hemorrhoid on the one hand, another is conveniently also beneficial to partially absorbing of intestinal, increase blood drug level.The ointment that anus external administration head is extruded, is beneficial to the coating of external hemorrhoid.The present invention once a day, each half an hour, after being used in conjunction 10 days, replying as usual, visits after half a year, without recurrence.
Example 3
Week certain, abdominal part falling inflation, proctoptosis, tinnitus, tired, breathe hard, conscious gas bearing down, has blood in stool, and emersion object has swelling sense, and companion breathes hard lazy speech, indigestion and loss of appetite loose stool, spiritlessness and weakness, lusterless complexion, white and thin fur, thready and weak pulse.Use the present invention: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 40g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 25g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 10g of Flos Celosiae Cristatae, Flos Chrysanthemi 10g.By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected, extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster, during use, after tearing plastic sealing pack, pricker is pulled up from shrouding, thrust successively along multiple dosing holes, medicine bag is punctured, then patient lies prone in bed, administration head in anus is inserted along anus place, in insertion process, due to extruding and the sphincteral extruding of hands, ointment in medicine bag is constantly flowed out along dosing holes, and, in insertion process, the expansion wing and soft plastic layer make it possess elasticity, along with the insertion of administration head in anus, the expansion wing scrapes the feces in large intestine inwall and fold, enable the ointment of administration head in anus directly contact intestinal wall as far as possible, be convenient to the administration of internal hemorrhoid on the one hand, another is conveniently also beneficial to partially absorbing of intestinal, increase blood drug level.The ointment that anus external administration head is extruded, is beneficial to the coating of external hemorrhoid.The present invention once a day, each half an hour, after being used in conjunction 12 days, replys as usual, visits after three months, without recurrence.
The plaster of object lesson 1: screen 160 routine patients in 4 hospitals, before test 1 week, carries out Continuous Observation to this crowd, record symptom and change, be divided into two groups, experimental group and matched group at random, experimental group uses embodiment 1 products obtained therefrom, and matched group takes the general prescription in background technology
Curative effect situation criterion: cure: after using this product, proctoptosis inside contracts, swelling disappears, and only, dizziness and tinnitus is improved blood; Effective: after taking and using this product, malaise symptoms makes moderate progress, blood only; Invalid: after using this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1:
| Group | Drug categories | Case load | Efficiently individual quantity | Healing number | Invalid number | Recurrence number | Cure rate | Total effective rate |
| Matched group | General prescription in background technology | 80 | 60 | 28 | 20 | 22 | 35% | 80% |
| Experimental group | The present invention | 80 | 72 | 67 | 8 | 5 | 83.7% | 90% |
Ointment of the present invention, with warming the spleen supporing yang to medicine Rhizoma Zingiberis, Fructus Tsaoko, what bowel relieving was stopped blooding is monarch drug to medicine Flos Sophorae, Radix Sanguisorbae, with warming middle-JIAO to relieve pain to medicine Flos Caryophylli, Fructus Evodiae, spleen invigorating circulation of qi promoting to medicine Poria, Fructus Aurantii, the removing toxic substances of clear spleen to medicine Rhizoma Cimicifugae, Radix Scrophulariae, temperature intestinal circulation of qi promoting to medicine Fructus Foeniculi, Pericarpium Citri Reticulatae, warming YANG activating QI be ministerial drug to medicine Ramulus Cinnamomi, Rhizoma Alismatis, with the Fructus Mori of intestine moistening, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, the Herba Centellae of removing toxic substances and promoting subsidence of swelling, the Fructus Toosendan of promoting the circulation of QI to relieve pain, the Flos Celosiae Cristatae of hemostasis is adjuvant drug, and Flos Chrysanthemi is for making medicine.
Proportioning of the present invention is simple, and easy to use, for sinking of QI due to deficiency of the spleen type hemorrhoid, the effective speed of external is fast.When the present invention uses, after tearing plastic sealing pack, pricker is pulled up from shrouding, thrust successively along multiple dosing holes, medicine bag is punctured, then patient lies prone in bed, administration head in anus is inserted along anus place, in insertion process, due to extruding and the sphincteral extruding of hands, ointment in medicine bag is constantly flowed out along dosing holes, and, in insertion process, the expansion wing and soft plastic layer make it possess elasticity, along with the insertion of administration head in anus, the expansion wing scrapes the feces in large intestine inwall and fold, enable the ointment of administration head in anus directly contact intestinal wall as far as possible, be convenient to the administration of internal hemorrhoid on the one hand, another is conveniently also beneficial to partially absorbing of intestinal, increase blood drug level.The ointment that anus external administration head is extruded, is beneficial to the coating of external hemorrhoid.The mode of this inside and outside directly administration of the present invention, except being directly administered into focus, can also partly by intestinal absorption, therapeutic effect is good, and responding time is fast.
Claims (4)
1. the ZHICHUANG GAO for sinking of QI due to deficiency of the spleen type, comprise cap (5), the two ends of cap (5) are provided with medicine bag (7), medicine bag (7) is built with ZHICHUANG GAO, it is characterized in that, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 40-60g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 25-40g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 10-20g of Flos Celosiae Cristatae, Flos Chrysanthemi 10-15g;
The middle part of cap (5) is gradually thin, the outer wrap of the medicine bag (7) of cap (5) side has administration head (3) in anus, anus external administration head (6) is enclosed with in the medicine bag (7) of the opposite side of cap (5), administration head (3) in anus, integratedly on the wall of anus external administration head (6) be provided with some dosing holes (4), be connected between dosing holes (4) with corresponding medicine bag (7), in anus, integrated being provided with in the front end of administration head (3) launches the wing (1), launch to be provided with soft plastic layer (2) between the wing (1) and medicine bag (7) outer wall, the end of anus external administration head (6) is integrated is provided with shrouding (8), shrouding (8) is ellipticity, administration head (3) in anus, anus external administration head (6) is rubber, administration head (3) in anus, be adhesively fixed between anus external administration head (6) and cap.
2. according to claim 1 for the ZHICHUANG GAO of sinking of QI due to deficiency of the spleen type, it is characterized in that, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 40-50g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 25-30g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 10-15g of Flos Celosiae Cristatae, Flos Chrysanthemi 10-12g.
3. according to claim 1 for the ZHICHUANG GAO of sinking of QI due to deficiency of the spleen type, it is characterized in that, the medicine activity component of ZHICHUANG GAO according to unit of weight proportioning is: Rhizoma Zingiberis, Fructus Tsaoko, Flos Sophorae, each 50-60g of Radix Sanguisorbae, Flos Caryophylli, Fructus Evodiae, Poria, Fructus Aurantii, Rhizoma Cimicifugae, Radix Scrophulariae, Fructus Foeniculi, Pericarpium Citri Reticulatae, Ramulus Cinnamomi, each 30-40g of Rhizoma Alismatis, Fructus Mori, Fructus Perillae, Semen Platycladi, Radix Polygoni Multiflori, Herba Centellae, Fructus Toosendan, each 15-20g of Flos Celosiae Cristatae, Flos Chrysanthemi 12-15g.
4., according to the arbitrary described ZHICHUANG GAO for sinking of QI due to deficiency of the spleen type of claim 1-3, it is characterized in that, preparation method is as follows:
A, be prepared as plaster:
By cataclasm for each active component, clean, dry, put in a hermetic container, add mass percent 75% alcoholic solution, each active component is made to infiltrate vexed bubble after 12 hours, each active component is loaded percolator, after adding mass percent 75% soak with ethanol, starts to collect percolate, collect 1000ml altogether, obtain extractum by after the 75% ethanol percolation liquid heating recovery ethanol collected; Extractum is added vegetable oil, makes extractum be dissolved in 500ml vegetable oil, the vegetable oil dissolving in medicine is heated to 70 DEG C, add mass percent 20% vitamin E ointment and stir, sterilizing, obtains plaster;
B, plaster is loaded on and wants in capsule and medicine bag, medicine bag is soft plastic product, in anus, administration head, anus external administration head are inner hollow and the ellipsoid shape rubber of one end open, medicine bag to be filled in respectively in anus in administration head and anus external administration head, in anus, the opening part of administration head, anus external administration head is adhesively fixed the both sides of cap
The shrouding of C, anus external administration head is plugged and connected with pricker; Administration head, the overall plastic sealing pack of anus external administration head in cap and anus.
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| CN201510693045.6A CN105288535A (en) | 2015-10-24 | 2015-10-24 | Hemorrhoids ointment for treating hemorrhoids with syndrome of spleen deficiency and Qi collapse |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2927996A1 (en) * | 2021-05-10 | 2022-11-14 | Beijing Marchheard Hightec Co | AN OINTMENT FOR HEMORRHOIDS AND THE METHOD OF PREPARING THE SAME (Machine-translation by Google Translate, not legally binding) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1247075A (en) * | 1998-09-09 | 2000-03-15 | 王奉炳 | Chinese patent medicine for treating piles |
| CN103301317A (en) * | 2013-06-06 | 2013-09-18 | 董霞 | Traditional Chinese medicine composition for treating Spleen deficiency qi collapse haememorrhoids |
-
2015
- 2015-10-24 CN CN201510693045.6A patent/CN105288535A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1247075A (en) * | 1998-09-09 | 2000-03-15 | 王奉炳 | Chinese patent medicine for treating piles |
| CN103301317A (en) * | 2013-06-06 | 2013-09-18 | 董霞 | Traditional Chinese medicine composition for treating Spleen deficiency qi collapse haememorrhoids |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2927996A1 (en) * | 2021-05-10 | 2022-11-14 | Beijing Marchheard Hightec Co | AN OINTMENT FOR HEMORRHOIDS AND THE METHOD OF PREPARING THE SAME (Machine-translation by Google Translate, not legally binding) |
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Application publication date: 20160203 |