CN105213775A - A kind of pharmaceutical composition for the treatment of heart disease - Google Patents

Abstract

The invention provides a kind of pharmaceutical composition for the treatment of heart disease, it is characterized in that this pharmaceutical composition prescription number is counted: Radix Panacis Quinquefolii 1-20 part, Radix Ophiopogonis 5-25 part, Radix Glycyrrhizae 1-20 part, Fructus Jujubae 10-30 part, Radix Pseudostellariae 15-40 part.Effect that pharmaceutical preparation of the present invention has.Prescription is simple, and scientific formulation is reasonable, evident in efficacy.

Description

A kind of pharmaceutical composition for the treatment of heart disease

Technical field

The invention belongs to field of traditional Chinese, be specifically related to a kind of pharmaceutical composition for the treatment of heart disease.

Background technology

Heart disease is the general name of heart disease, comprises the various heart diseases such as rheumatic heart disease, congenital heart disease, hypertensive heart disease, coronary heart disease, myocarditis.The number one killer of the mankind is sudden cardiac arrest (being called for short SCA).At present according to the numeral that World Health Organization (WHO) issues, the whole world, often in dead 3 people, just has 1 people to die from cardiovascular disease, China, has hundreds of thousands people to die from heart disease every year.Heart disease has very large puzzlement and threat to patient, although have in some now, western medicine mode, curative effect is all comparatively general, can not effectively alleviate heart disease preferably and treat.Therefore, develop a kind ofly to have no side effect, scientific formulation, taking convenience, treatment heart disease evident in efficacy medicine be desirable.

Summary of the invention

The present invention aims to provide a kind of scientific formula, evident in efficacy, the Chinese medicine composition for the treatment of heart disease that has no side effect.

For achieving the above object, a kind of pharmaceutical composition for the treatment of heart disease of the present invention, its specific embodiments is:

A kind of pharmaceutical composition for the treatment of heart disease of the present invention, is characterized in that this pharmaceutical composition prescription number is counted: Radix Panacis Quinquefolii 1-20 part, Radix Ophiopogonis 5-25 part, Radix Glycyrrhizae 1-20 part, Fructus Jujubae 10-30 part, Radix Pseudostellariae 15-40 part.

Further, a kind of pharmaceutical composition for the treatment of heart disease of the present invention, is characterized in that this pharmaceutical composition prescription number is counted: Radix Panacis Quinquefolii 12 parts, Radix Ophiopogonis 15 parts, 10 parts, Radix Glycyrrhizae, 15 parts, Fructus Jujubae, Radix Pseudostellariae 20 parts.

Further, a kind of pharmaceutical composition for the treatment of heart disease of the present invention, is characterized in that one or more drug regimens in the same Radix Ginseng Rubra of this pharmaceutical composition, Rhizoma Polygonati Odorati, Semen Coicis, Exocarpium Citri Rubrum, Rhizoma Chuanxiong use.

Pharmaceutical composition described in any one of the present invention, is characterized in that, described preparation is oral formulations.

Further, preparation of the present invention, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, capsule, granule, electuary and oral liquid.

Further, preparation of the present invention, is characterized in that, described preparation is water decoction.

Further, preparation of the present invention, is characterized in that, the preparation method of this water decoction is:

1) by recipe quantity Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Radix Pseudostellariae six medical material warm water is soaked 20 minutes (water yield of immersion is advisable to flood powder 2 ~ 3cm);

2) be placed on fire by medicine, endure out with big fire, timing after boiling, decocts 60 minutes;

3) poured out by first time fried medicinal liquid, add appropriate hot water (being advisable just to flood medical material) and carry out second time and decoct, the time that second time decocts is about 0.5-1 hour, will first time medicinal liquid mix with medicinal liquid for the second time, to obtain final product.

The each component pharmacology analysis of prescription of the present invention:

Radix Panacis Quinquefolii: sweet, micro-hardship, cool. GUIXIN, lung, kidney channel. boosting qi and nourishing yin, relieves inflammation or internal heat and promotes the production of body fluid.

Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.Return lung, the heart, stomach warp.Radix Ophiopogonis effect: nourishing YIN and moistening the lung, reinforcing stomach reg fluid, clear away heart-fire relieving restlessness.

Radix Glycyrrhizae: sweet, flat.GUIXIN, spleen, lung, stomach warp.Radix Glycyrrhizae effect: invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, heat-clearing and toxic substances removing, alleviates pain relieving, relaxes the property of medicine.

Fructus Jujubae: sweet, temperature.Return spleen, stomach warp.Fructus Jujubae effect: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, relaxes the property of medicine..

Radix Pseudostellariae: sweet, micro-hardship, flat.Return spleen, lung meridian.Radix Pseudostellariae effect: tonifying QI to produce body fluid.

Radix Ginseng Rubra: sweet, micro-hardship, tepor.Return spleen, lung meridian.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, nourishing qi to stop.

Rhizoma Polygonati Odorati: sweet, flat.Attach to the lung and stomach meridians.Rhizoma Polygonati Odorati effect: nourishing YIN and moistening the lung, nourishing the stomach of promoting the production of body fluid.

Semen Coicis:: sweet, light, be slightly cold.Return spleen, stomach, lung meridian.Semen Coicis effect: promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, damp eliminating eliminating impediment, clearing away heat and discharging pus.

Exocarpium Citri Rubrum: acrid in the mouth, hardship, warm in nature.Return lung, spleen channel.Regulating the flow of QI to ease the stomach, drying dampness to eliminate phlegm.

Rhizoma Chuanxiong: pungent, temperature.Return liver, gallbladder, pericardium channel.Rhizoma Chuanxiong effect: blood-activating and qi-promoting, wind-expelling pain-stopping.

Radix Panacis Quinquefolii of the present invention, Radix Pseudostellariae tonifying QI to produce body fluid are our monarch drug, and Radix Ophiopogonis, stomach reinforcing cleared away heart-fire for our ministerial drug, Radix Glycyrrhizae, Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, coordinating the actions of various ingredients in a prescription.The main benefit of we consolidates, and body void person be cautious use of.

Beneficial effect of the present invention is:

1. prescription scientific formulation, evident in efficacy.

2. prescription crude drug source is wide, and technique is simple, is applicable to large-scale production, has industrialization prospect.

Detailed description of the invention

The present invention is further illustrated below for embodiment.

Embodiment 1

Prescription:

Radix Panacis Quinquefolii 12 parts, Radix Ophiopogonis 15 parts, 10 parts, Radix Glycyrrhizae, 15 parts, Fructus Jujubae, Radix Pseudostellariae 20 parts.

Preparation technology:

1) by recipe quantity Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Radix Pseudostellariae six medical material warm water is soaked 20 minutes (water yield of immersion is advisable to flood powder 2 ~ 3cm);

2) be placed on fire by medicine, endure out with big fire, timing after boiling, decocts 60 minutes;

3) first time fried medicinal liquid is poured out, adds appropriate hot water (being advisable just to flood medical material) and carry out second time and decoct, the about 0.5 hour time that second time decocts, will first time medicinal liquid mix with medicinal liquid for the second time, to obtain final product.

Embodiment 2

Prescription:

Radix Panacis Quinquefolii 12 parts, Radix Ophiopogonis 15 parts, 10 parts, Radix Glycyrrhizae, 15 parts, Fructus Jujubae, Rhizoma Polygonati Odorati 20 parts.

Preparation technology:

1) by recipe quantity Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Radix Pseudostellariae six medical material warm water is soaked 20 minutes (water yield of immersion is advisable to flood powder 2 ~ 3cm);

2) be placed on fire by medicine, endure out with big fire, timing after boiling, decocts 60 minutes;

3) first time fried medicinal liquid is poured out, adds appropriate hot water (being advisable just to flood medical material) and carry out second time and decoct, the about 1 hour time that second time decocts, will first time medicinal liquid mix with medicinal liquid for the second time, to obtain final product.

Embodiment 3

Prescription:

Radix Panacis Quinquefolii 12 parts, Radix Ophiopogonis 15 parts, 10 parts, Radix Glycyrrhizae, 15 parts, Fructus Jujubae, Radix Pseudostellariae 20 parts.

Preparation Technology of Granules:

1) by Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Radix Pseudostellariae gomi herbs wears into coarse powder, and mixing, according to the percolation under fluid extract and extractum item, with 6 times amount 60% ethanol as solvent, flood 18 hours, slowly percolation, collect 6 times amount and to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;

2) medicinal residues add 8 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, dry, granule processed and get final product.

Embodiment 4

Prescription:

Radix Panacis Quinquefolii 12 parts, Radix Ophiopogonis 15 parts, 10 parts, Radix Glycyrrhizae, 15 parts, Fructus Jujubae, Radix Pseudostellariae 20 parts.

Capsule preparation technology:

1) by Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Radix Pseudostellariae gomi herbs wears into coarse powder, and mixing, according to the percolation under fluid extract and extractum item, with 6 times amount 60% ethanol as solvent, flood 18 hours, slowly percolation, collect 6 times amount and to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;

2) medicinal residues add 8 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, dry, granulation filled capsules and get final product.

Embodiment 5

Prescription:

Radix Panacis Quinquefolii 12 parts, Radix Ophiopogonis 15 parts, 10 parts, Radix Glycyrrhizae, 15 parts, Fructus Jujubae, Radix Pseudostellariae 20 parts.

Tablet producing technology:

1) by Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Radix Pseudostellariae gomi herbs wears into coarse powder, and mixing, according to the percolation under fluid extract and extractum item, with 6 times amount 60% ethanol as solvent, flood 18 hours, slowly percolation, collect 6 times amount and to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;

2) medicinal residues add 8 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, dry, granulate, tabletting and get final product.

Clinical application effect of the present invention:

One, physical data accepts patient's totally 150 examples for medical treatment, 50 years old mean age.

Two, Therapeutic Method is according to Medications Example one of the present invention, and decoction prepared by preferred preparation method, one day three times, decoction being taken warmly.It within 60th, is a course for the treatment of.Three, therapeutic outcome statistics

Treat after 60 days, fully recover 88 people, effective 53 people, invalid 9 people, total effective rate 94%.Wherein: total effective rate=cure rate+effective percentage.It should be noted that; above-described embodiment is only preferred embodiment of the present invention; be not used for limiting protection scope of the present invention; protection scope of the present invention is as the criterion with claims; equivalent replacement done on the basis of technique scheme or substitute, all belongs to protection scope of the present invention.

Claims (7)

1. treat a pharmaceutical composition for heart disease, it is characterized in that this pharmaceutical composition prescription number is counted: Radix Panacis Quinquefolii 1-20 part, Radix Ophiopogonis 5-25 part, Radix Glycyrrhizae 1-20 part, Fructus Jujubae 10-30 part, Radix Pseudostellariae 15-40 part.

2. a kind of pharmaceutical composition for the treatment of heart disease according to claim 1, is characterized in that this pharmaceutical composition prescription number is counted: Radix Panacis Quinquefolii 12 parts, Radix Ophiopogonis 15 parts, 10 parts, Radix Glycyrrhizae, 15 parts, Fructus Jujubae, Radix Pseudostellariae 20 parts.

3. a kind of pharmaceutical composition for the treatment of heart disease according to claim 1, is characterized in that one or more drug regimens in the same Radix Ginseng Rubra of this pharmaceutical composition, Rhizoma Polygonati Odorati, Semen Coicis, Exocarpium Citri Rubrum, Rhizoma Chuanxiong use.

4. the pharmaceutical composition according to any one of claim 1-2, is characterized in that, described preparation is oral formulations.

5. preparation according to claim 4, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, capsule, granule, electuary and oral liquid.

6. preparation according to claim 5, is characterized in that, described preparation is water decoction.

7. preparation according to claim 6, is characterized in that, the preparation method of this water decoction is:

1) by recipe quantity Radix Panacis Quinquefolii, Radix Ophiopogonis, Radix Glycyrrhizae, Fructus Jujubae, Radix Pseudostellariae six medical material warm water is soaked 20 minutes (water yield of immersion is advisable to flood powder 2 ~ 3cm);

2) be placed on fire by medicine, endure out with big fire, timing after boiling, decocts 60 minutes;

3) poured out by first time fried medicinal liquid, add appropriate hot water (being advisable just to flood medical material) and carry out second time and decoct, the time that second time decocts is about 0.5-1 hour, will first time medicinal liquid mix with medicinal liquid for the second time, to obtain final product.