CN105194474B - It is a kind of multi-functional except acarid emulsion and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of multi-functional except acarid lotion and preparation method thereof.The lotion contains raw material components: tuber of stemona extracting solution, cortex phellodendri extract, Radix Sophorae Flavescentis extractive liquid, soapberry extract, root bark of white mulberry extracting solution, licorice extract, green tea extractive liquor, peppermint extracting solution, centella asiatica extract, distilled water, grape seed oil, olive oil, snake oil, compound emulsifying agent AC-402, sodium alginate, ethylparaben.Multi-functional lotion of the invention can promote patient health to grow up, and reduce skin lesion range caused by acarid, restore the normal barrier function of skin, perfect surface layer, and the effective acarid for reducing skin surface has the effects that good antipruritic and whitening of deoiling.Meanwhile emulsion property is mild, stability is high, all using the effective component in natural medicinal plant in conjunction with mild surfactant, can play the role of removing acarid and inhibit acarid growth；It is antipruritic also there is dispel scar, oil-control of certain whitening to skin at the same time.

Description

It is a kind of multi-functional except acarid emulsion and preparation method thereof

Technical field

It is the present invention relates to a kind of multi-functional except acarid emulsion and preparation method thereof, in particular to a kind of multi-functional except acarid Lotion and preparation method thereof belongs to art of pharmacy.

Background technique

Acarid likes humidity, high temperature, there is ramie cotton fabric or has the environment of dirt, and damp and hot environment is exactly acarid development breeding In most vigorous season, this can become the floating material in air, can cause a series of allergic reactions after sensitive group sucking and painful Unbearably, therefore many people wonder how acarid is controlled.The acarid for colonizing in human body is broadly divided into two kinds, one is follicle mites, Also people vermiform mite is cried, another kind is named sebaceous glands mite, colonizes in the sebaceous glands of human face, general to be also just referred to as acarid.

Acarid is generally divided into several major class such as dust mite, flour mite, gamasid, Qiang mite, is that a kind of naked eyes are not easy the miniature pest seen, Acarid is distributed widely in the dark corner in room, carpet, mattress, pillow, sofa, air-conditioning, summer sleeping mat etc., the wherein distribution of dust mite Most wide, influence maximum, corpse, secretion and the excreta of acarid are all anaphylactogens, can make one allergic dermatitis, asthma occur The diseases such as disease, bronchitis, ephritis, allergic rhinitis seriously endanger human health.

The social pressures that current people face are increasing, and lessons are more, and worry weight leads to endocrine disorder, given acarid More chances for invading people.Skin problem caused by acarid is increasingly severe.There is red grouper, mound on the face in people's The symptoms such as rash, useless fellow, acne, fuel-displaced and itch, have seriously affected daily life and work.Skin ingress of oil, red grouper, Acne are the very big damage to people's appearance, and the very big strike to self-confidence.

Anti-mite drug currently on the market is mostly based on chemicals, although playing certain effect in anti-mite, It is also to have biggish damage to the skin of human body itself while anti-mite.Human body skin is colonized in so both can effectively reduce It is the people for being very suitable to just enduring to the fullest extent acarid disaster now that the acarid of skin, which can be reduced again to the product of skin lesion,.

Summary of the invention

The purpose of the present invention is to provide a kind of multi-functional except acarid emulsion and preparation method thereof.

To achieve the above object, the present invention adopts the following technical scheme:

One kind of the invention is multi-functional to remove acarid emulsion, wherein including the raw material of following proportion:

It is described above multi-functional except common pharmaceutical dosage form being made by adding conventional pharmaceutical adjuvants in acarid emulsion.

It is described above multi-functional except can add 2-7g compound emulsifying agent AC-402 and emulsion is made in acarid emulsion.

It is described above multi-functional except may further be enriched with 0.5-4g sodium alginate, 1-4ml5%-6% Ni Bo in acarid emulsion Golden ethyl ester alcoholic solution, ethylparaben alcoholic solution are the solution that ethylparaben is dissolved in the formation of 75% ethyl alcohol, and the percentage is equal For weight ratio.

It is of the invention described multi-functional except in acarid emulsion, the tuber of stemona extracting solution, Radix Sophorae Flavescentis extractive liquid, cortex phellodendri extract, It is soapberry extract, licorice extract, frutus cnidii extracting solution, wild chrysanthemum extracting solution, peppermint extracting solution, centella asiatica extract, green Tea extract is extracted by using distilled water, and filtering is concentrated to get；The distilled water is extracted using refluxing extraction side three times Add distilled water immersion refluxing extraction 1-2h for the first time, second plus distilled water refluxing extraction 0.5-1.5h, for the third time plus distill likes: Water refluxing extraction 0.5-1.5h；The filtering is to be filtered the feed liquid after each refluxing extraction respectively, remerge institute three times Obtain filtrate.It is specific:

The tuber of stemona extracting solution is prepared by the following method:

It is appropriate to weigh the tuber of stemona, is ground into coarse powder, decocts and extracts three times, add the 15-20 times of water measured for the first time, extract 1- 1.5h, for the second time plus 12-15 times is measured water, extracts 1-1.2h, and third time plus 8-10 times measure water, extraction 0.5-0.8h, every time with three Layer gauze filtration, merging filtrate, filtrate are concentrated into 5-7 times of tuber of stemona weight, filter to obtain the final product；

The cortex phellodendri extract is prepared by the following method:

It is appropriate to weigh Cortex Phellodendri, is ground into coarse powder, impregnates 0.15-0.8h, heating, which decocts, extracts three times, first time plus 25-30 Amount water again, extraction 1-2h, for the second time plus 15-20 times is measured water, extraction 0.5-1.5h, and third time adds 10-15 times to measure water, extraction 0.5- 1.5h, filters every time, and merging filtrate, filtrate is concentrated into 4-6 times of Cortex Phellodendri weight, filters to obtain the final product；

The Radix Sophorae Flavescentis extractive liquid is prepared by the following method:

It is appropriate to weigh kuh-seng, is ground into coarse powder, impregnates 0.15-0.8h, heating, which decocts, extracts three times, first time plus 25-30 Amount water again, extraction 1-2h, for the second time plus 15-20 times is measured water, extraction 0.5-1.5h, and third time adds 10-15 times to measure water, extraction 0.5- 1.5h, filters every time, and merging filtrate, filtrate is concentrated into 4-6 times of kuh-seng weight, filters to obtain the final product；

The frutus cnidii extracting solution is prepared by the following method:

It is appropriate to weigh frutus cnidii, three times, for the first time plus 18-20 times is measured water for extraction, is extracted 1-1.5h, is added 12-15 for the second time Amount water again extracts 0.7-1h, and third time plus 8-10 times measure water, and extraction 0.3-0.6h is filtered, merging filtrate every time, filtrate concentration To 3-5 times of frutus cnidii weight, filter to obtain the final product；

The soapberry extract is prepared by the following method:

It is appropriate to weigh soapberry, is ground into coarse powder, extracts three times, for the first time plus 16-20 times is measured water, 1-1.8h is extracted, the It is secondary to add 10-15 times to measure water, 1-1.2h is extracted, third time plus 8-10 times measure water, 0.5-1h is extracted, each to filter, merging filtrate, Filtrate is concentrated into 4-6 times of the weight of soapberry, filters to obtain the final product；

The licorice extract is prepared by the following method:

It is appropriate to weigh Radix Glycyrrhizae, is ground into coarse powder, impregnates 0.3-0.5h, is heated to 100 DEG C, decocts and extracts three times, for the first time Add 12-15 times to measure water, extract 1-1.5h, second plus 8-10 times measure water, extract 0.8-1h, and third time plus 6-8 times measure water, extract 0.5-0.8h, filters every time, and merging filtrate, filtrate is concentrated into 3-5 times of Radix Glycyrrhizae weight, filters to obtain the final product；

The wild chrysanthemum extracting solution is prepared by the following method:

It is appropriate to weigh wild chrysanthemum, three times, for the first time plus 15-20 times is measured water for extraction, is extracted 1.3-1.6h, is added 10- for the second time 15 times of amount water extract 1-1.2h, and third time plus 5-9 times measure water, extract 0.5-0.9h, filter every time, merging filtrate, filtrate concentration To 4-6 times of wild chrysanthemum weight, filter to obtain the final product；

The peppermint extracting solution is prepared by the following method:

It is appropriate to weigh peppermint, is ground into coarse powder, extracts three times, for the first time plus 16-20 times is measured water and extract 1-1.5h, for the second time Adding 10-15 times to measure water, extracts 0.8-1h, third time plus 5-10 times measure water, and 0.3-0.8h is extracted, is filtered every time, merging filtrate, filter Liquid is concentrated into 5-7 times of peppermint weight, filters to obtain the final product；

The centella asiatica extract is prepared by the following method:

It is appropriate to weigh centella, is ground into coarse powder, decocts and extracts three times, for the first time plus 10-15 times is measured water, 1-2h is extracted, For the second time plus 8-10 times is measured water, extracts 1-1.5h, and third time plus 5-8 times measure water, and extraction 0.5-1h is filtered, merging filtrate every time, Filtrate is concentrated into 3-6 times of the weight of centella, filters to obtain the final product；

The green tea extractive liquor is to be prepared by the following method:

It is appropriate to weigh green tea, extracts three times, for the first time plus 10-15 times is measured water and extract 1-1.5h, and second plus 8-10 times are measured Water extracts 0.5-1h, and third time plus 5-8 times measure water, extracts 0.5-1h, filters every time, merging filtrate, filtrate concentration most green tea 4-6 times of weight, is filtered to obtain the final product；

The dosage of water described in above-mentioned each extraction each means the multiple relative to raw medicinal material weight, filtrate after concentration Amount is the multiple of medicinal material weight.

The multi-functional preparation method except acarid emulsion of the present invention, comprising the following steps:

A) clean beaker is taken, snake oil 1-9g, olive oil 1.5-10g, grape grape seed oil 1-12g are weighed, is added in this beaker Enter compound emulsifying agent AC-4022-7g, set heating water bath on 60-88 DEG C of water-bath, as oily phase；

B) 4-9ml distilled water is measured, heating water bath on 60-88 DEG C of water-bath is set, as water phase；

C) it to oily mutually identical with water phase temperature, is mutually added to oily in water phase in thread shape, it is stirring while adding until being formed Uniform emulsion bases 1；

D) tuber of stemona extracting solution 2-12g, Radix Sophorae Flavescentis extractive liquid 1.3-6g, cortex phellodendri extract 1.3-6g are weighed respectively, and soapberry mentions Take liquid 0.4-4g, licorice extract 0.4-4g, frutus cnidii extracting solution 0.7-5g, wild chrysanthemum extracting solution 0.5-3g, peppermint extracting solution 0.6-4.5g, centella asiatica extract 0.3-3.5g, green tea extractive liquor 0.4-3g are uniformly mixed, as solution 1；

E) 0.5-4g sodium alginate is weighed, is dispensed into 30-70ml distilled water, coagulant liquid 1 is formed；

F) solution 1, coagulant liquid 1 are added in emulsion bases 1, are stirred, it is molten to measure 5-6% ethylparaben alcohol Liquid 1-4ml is added thereto, be thoroughly mixed uniformly to get.

In the present invention:

The tuber of stemona embellishes but not dry, and can open drop-down gas, clearing lung-heat heat and inducing diaphoresis, is used for skin scabies, eczema, psoriasis, Huang all over The symptoms such as swollen, dermatitis, desinsection.People carry out desinsection and delousion using the tuber of stemona very early.According to Qing Dynasty's medicine ancient books and records " book on Chinese herbal medicine is newly organized " note It carries, tuber of stemona desinsection is without being lost qi and blood, most useful for people.It is used for head louse, body louse, acarid, pinworm, pudendal pruritus, roundworm disease outside Etc. diseases.

Kuh-seng has the effect of heat-clearing and damp-drying drug, desinsection, is used for swelling of vulva pruritus vulvae, pruitus.It is wet that kuh-seng bath can remove lower coke Heat, and desinsection is antipruritic, has good relaxation effect to pruitus.Can Bergamot Mint Extract, dredge and restrain pore, clearly Except skin endotoxin contamination, there is good effect to skin ingress of oil caused by acarid.

The effect of Cortex Phellodendri is heat-clearing and damp-drying drug, and hygropyretic dysentery, pruitus are treated in purging fire for removing toxin, and there is skin sore removing toxic substances to treat The effect of sore.

Soapberry itself adds water that can generate many foams, so being employed for cleaning aspect very early.Soapberry kind Son has heat-clearing eliminating the phlegm, the effect of disperse accumulation desinsection.

Radix Glycyrrhizae contains nearly 12% Radix Glycyrrhizae acid amide, is a kind of anti-inflammatory ingredient of releiving of good skin, and in energy and/or release The effect of noxious material of skin, performance whitening and skin-protecting.Whitening function is about ascorbic 80 times, also have it is anti-oxidant, prevent The only effect that skin aging blacks.

Frutus cnidii has the function of wind dispelling insecticide.Frutus cnidii and kuh-seng, which share, can be used for clearing damp detoxifying and relieving itching, be suitable for mite Pruitus caused by worm.Kuh-seng and frutus cnidii are with heat-clearing and damp-drying drug, based on desinsection is antipruritic.Frutus cnidii and tuber of stemona combination have heat-clearing sharp It is wet, detoxify stop-band the effect of.A variety of symptoms caused by acarid can effectively be slowed down.

Wild chrysanthemum has dispelling wind and heat from the body, antibacterial, antiviral effect.Wild chrysanthemum treats skin scabies caused by mite infection Itch, it is on the books to play antipruritic effect with the drug matchings such as kuh-seng, cortex dictamni, wild chrysanthemum use.The immersion liquid pair of wild chrysanthemum Some helminths have good inhibiting effect.

Peppermint is pungent cool property sweating antipyretic medicine, has suppression worm sterilization, decomposes the function of lipid.Acarid can effectively be improved The symptom of caused skin ingress of oil and pruitus.External application can improve the skin of unclean obstruction, there is refrigerant feeling, energy Capilary is shunk, vivotoxin is excluded, improves symptom caused by acarid, soft skin.

Centella have it is clearing heat and detoxicating, it is inducing diuresis and reducing edema, nourishing, anti-inflammatory effect.Deep skin cell can be stimulated to substitute.It can With the coupling part of compact epidermis and corium, skin can be made to limber up, skin is made to become smooth and elastic.Centella is suitable for each Kind skin quality, has certain antibacterial action.In this product, so that this product other than having effects that anti-mite, also has one Fixed beautification function.

Tea polyphenols inside green tea are water-soluble substances, have good antioxidant effect, and can keep the skin wet consolidation skin, It delays senescence.The greasy of face is cleaned with it, restrains pore.Effect of the green tea in terms of whitening and skin-protecting anti-aging is to be recognized 's.The problem of having not only acted as skin ingress of oil caused by alleviation acarid also acts the effect of whitening.

Olive oil has the function of improving endocrine system.Rich in the squalene and human body splendid with skin affinity Essential fatty acid, absorption rapidly, effectively keep skin elasticity and moisten；In olive oil contained monounsaturated fatty acids abundant and Vitamin E, K, A, D etc. and phenols antioxidant, can eliminate facial wrinkles, prevent skin aging, also have anticracking antipruritic Effect.

Grape seed oil can restore collagen activity, keep skin smooth and flexible.Grape pip or natural sunlight hide Cover material can prevent ultraviolet damage skin, can adjust dry skin, skin whitening caused by endocrine disorder.

Snake oil can removing toxicity for detumescence, moisturizing anticracking, adjust endocrine disorder, beautifying face and moistering lotion prevents skin aging, inhibits thin Bacterium, helminth the effect of.

Multi-functional lotion produced by the present invention can promote patient health to grow up, and reduce skin lesion model caused by acarid It encloses, restores the normal barrier function of skin, perfect surface layer, the effective acarid for reducing skin surface has good deoil only Itch and the effects of whitening.Meanwhile emulsion property is mild, stability is high, all using in natural medicinal plant effective component and The method that mild surfactant combines can play the role of removing acarid and inhibit acarid growth；It is also right at the same time It is antipruritic that skin plays the role of dispel scar, oil-control of certain whitening.

Specific embodiment

Following embodiments are further explanations for the content of present invention using as the explaination to the technology of the present invention content, but Substantive content of the invention is not limited in described in following embodiments, those skilled in the art can with and should know appoint What simple change or replacement based on true spirit should belong to protection scope of the presently claimed invention.

Embodiment 1

The preparation of 1.1 tuber of stemona extracting solutions

500 grams of the tuber of stemona are weighed, is ground into coarse powder, decocts and extracts three times, for the first time plus 20 times of water, extracts 1.5h, second Secondary plus 15 times of water extract 1h, third time plus 10 times of water, extract 0.5h, are filtered every time with three layers of gauze, merging filtrate, filtrate is dense 7 times for being reduced to tuber of stemona weight are spare.

The preparation of 1.2 cortex phellodendri extracts

Cortex Phellodendri 50g is weighed, coarse powder is ground into, impregnates 0.5h, heating, which decocts, extracts three times, and first time plus 27 times of amount water mention 1.5h is taken, second plus 18 times of amount water extract 1h, third time plus 12 times of amount water, extract 0.5h, filter every time, and filtrate merges, filter Liquid be concentrated into the weight of kuh-seng 4 times are spare.

The preparation of 1.3 Radix Sophorae Flavescentis extractive liquids

Kuh-seng 40g is weighed, coarse powder is ground into, impregnates 0.5h, heating, which decocts, extracts three times, and first time plus 28 times of amount water mention 2h is taken, second plus 17 times of amount water extract 1.5h, third time plus 13 times of amount water, extract 1h, filter every time, filtrate merges, filtrate 4 times for being concentrated into kuh-seng weight are spare.

The preparation of 1.4 frutus cnidii extracting solutions

60.0 grams of frutus cnidii are weighed, extracts three times, adds 18 times of amount water for the first time, extracts 1h, second plus 12 times of amount water mention Take 1h, third time plus 8 times of amount water extract 0.5h, every time filtration, merging filtrate, and filtrate be concentrated into the weight of frutus cnidii 3 times are standby With.

The preparation of 1.5 soapberry extracts

100.4 grams of soapberry are weighed, is ground into coarse powder, extraction 3 times, for the first time plus 16 times of amount water, extraction 1h add for the second time 10 times of amount water extract 1h, third time plus 8 times of amount water, extract 0.5h, filter every time, merging filtrate, filtrate is concentrated into soapberry 4 times of weight are spare.

The preparation of 1.6 licorice extracts

Radix Glycyrrhizae 100g is weighed, coarse powder is ground into, impregnates 0.3h, is heated to 100 DEG C, decocts and extracts three times, add 12 for the first time Amount water again extracts 1h, second plus 8 times of amount water, extraction 1h, third time plus 6 times of amount water, extracts 0.5h, every time filtration, merge filter Liquid, filtrate be concentrated into the weight of Radix Glycyrrhizae 3 times are spare.

The preparation of 1.7 wild chrysanthemum extracting solutions

10 grams of wild chrysanthemum are weighed, extracts three times, adds 15 times of amount water for the first time, extracts 1.3h, second plus 10 times of amount water mention Take 1h, third time plus 5 times of amount water extract 0.5h, every time filtration, merging filtrate, and filtrate be concentrated into the weight of wild chrysanthemum 4 times are standby With；

The preparation of 1.8 peppermint extracting solutions

40.0 grams of peppermint are weighed, coarse powder is ground into, three times, for the first time plus 16 times of amount water extract 1h for extraction, add 10 for the second time Amount water extracts 1h, third time plus 5 times of amount water again, and extraction 0.5h is filtered every time, and merging filtrate, filtrate is concentrated into the weight of peppermint 5 times it is spare.

The preparation of 1.9 centella asiatica extracts

Centella 50g is weighed, coarse powder is ground into, decoction is extracted three times, adds 12 times of amount water for the first time, extracts 1h, for the second time Add 8 times of amount water, extract 1h, third time plus 6 times of amount water, extracts 0.5h, filter every time, merging filtrate, filtrate is concentrated into centella 3 times of weight it is spare.

The preparation of 1.10 green tea extractive liquors

30.0 grams of green tea are weighed, is ground into coarse powder, three times, for the first time plus 10 times of amount water, extraction 1h add 8 for the second time for extraction Amount water again extracts 1h, third time plus 5 times of amount water, and extraction 0.5h is filtered every time, and merging filtrate, filtrate is concentrated into the weight of green tea 4 times it is spare.

The preparation of 1.11 emulsions

A) clean beaker is taken, snake oil 3g, olive oil 3g are weighed, composite emulsifying is added in this beaker in grape grape seed oil 3g Agent AC-4023g sets heating water bath on 70 DEG C of water-baths, as oily phase；

B) 5ml distilled water is measured, heating water bath on 75 DEG C of water-baths is set, as water phase；

C) it to oily mutually identical with water phase temperature, is mutually added to oily in water phase in thread shape, it is stirring while adding until being formed Uniform emulsion bases 1；

D) tuber of stemona extracting solution 3g, Radix Sophorae Flavescentis extractive liquid 4g, cortex phellodendri extract 3g, soapberry extract 3g, Radix Glycyrrhizae are weighed respectively Extracting solution 3g, frutus cnidii extracting solution 2g, wild chrysanthemum extracting solution 2g, peppermint extracting solution 2g, centella asiatica extract 2g, green tea extractive liquor 2g is uniformly mixed, as solution 1；

E) 1g sodium alginate is weighed, is dispensed into 50ml distilled water, coagulant liquid 1 is formed；

F) solution 1, coagulant liquid 1 are added in emulsion bases 1, are stirred, measure 5.34% ethylparaben alcohol Solution 2ml is added thereto, and is thoroughly mixed uniformly to get multi-functional except acarid emulsion.

Embodiment 2

The preparation of 2.1 tuber of stemona extracting solutions

300 grams of the tuber of stemona are weighed, coarse powder is ground into, decocts and extracts three times, add the water of 20 times of amounts for the first time, extracts 1.5h, the Secondary plus 14 times of amount water extract 1.2h, third time plus 10 times of amount water, extract 0.8h, are filtered every time with three layers of gauze, merge filter Liquid, filtrate be concentrated into the weight of the tuber of stemona 7 times are spare.

The preparation of 2.2 cortex phellodendri extracts

Cortex Phellodendri 40g is weighed, coarse powder is ground into, impregnates 0.4h, heating, which decocts, extracts three times, and first time plus 26 times of amount water mention 1.5h is taken, second plus 16 times of amount water extract 1h, third time plus 10 times of amount water, extract 0.5h, filter every time, and filtrate merges, filter Liquid be concentrated into Cortex Phellodendri weight 5 times are spare.

The preparation of 2.3 Radix Sophorae Flavescentis extractive liquids

Kuh-seng 50g is weighed, coarse powder is ground into, impregnates 0.2h, heating, which decocts, extracts three times.Add 25 times of amount water for the first time, mentions 1.5h is taken, second plus 20 times of amount water extract 1.2h, third time plus 10 times of amount water, extract 0.8h, filter every time, and filtrate merges, Filtrate be concentrated into kuh-seng weight 5 times are spare.

2.4 the preparation of frutus cnidii extracting solution

50.0 grams of frutus cnidii are weighed, coarse powder is ground into, extracts three times, adds 20 times of amount water for the first time, extracts 1.5h, for the second time Add 15 times of amount water, extract 1h, third time plus 10 times of amount water, extracts 0.6h, filter every time, merging filtrate, filtrate is concentrated into cnidium monnieri 5 times of the weight of son are spare.

The preparation of 2.5 soapberry extracts

80 grams of soapberry are weighed, is ground into coarse powder, extraction 3 times, for the first time plus 20 times of amount water, extraction 1.8h add for the second time 15 times of amount water extract 1.2h, third time plus 10 times of amount water, extract 1h, filter every time, merging filtrate, filtrate is concentrated into soapberry 6 times of weight it is spare.

The preparation of 2.6 licorice extracts

Radix Glycyrrhizae 70g is weighed, coarse powder is ground into, impregnates 0.5h, is heated to 100 DEG C, decocts and extracts three times, add 15 times for the first time Water is measured, 1.5h is extracted, second plus 10 times of amount water extract 1h, third time plus 8 times of amount water, extract 0.8h, filter every time, merge Filtrate, filtrate is concentrated into plus 5 times of weight of Radix Glycyrrhizae spare.

The preparation of 2.7 wild chrysanthemum extracting solutions

15 grams of wild chrysanthemum are weighed, extracts three times, adds 20 times of amount water for the first time, extracts 1.6h, second plus 15 times of amount water mention 1.2h, third time plus 9 times of amount water are taken, 0.9h is extracted, filters every time, merging filtrate, filtrate is concentrated into 6 times of the weight of wild chrysanthemum It is spare.

The preparation of 2.8 peppermint extracting solutions

30.0 grams of peppermint are weighed, is ground into coarse powder, three times, for the first time plus 20 times of amount water, extraction 1.5h add for the second time for extraction 15 times of amount water extract 1h, third time plus 10 times of amount water, extract 0.8h, filter every time, merging filtrate, filtrate is concentrated into peppermint 7 times of weight are spare.

The preparation of 2.9 centella asiatica extracts

Centella 30g is weighed, coarse powder is ground into, decoction is extracted three times, adds 15 times of amount water for the first time, extracts 2h, for the second time Add 10 times of amount water, extract 1.5h, third time plus 8 times of amount water, extracts 1h, filter every time, merging filtrate, filtrate is concentrated into centella 6 times of weight it is spare.

The preparation of 2.10 green tea extractive liquors

40.0 grams of green tea are weighed, coarse powder is ground into, three times, for the first time plus 15 times of amount water extract 1.5h for extraction, add for the second time 10 times of amount water extract 1h, third time plus 8 times of amount water, extract 1h, filter every time, merging filtrate, filtrate is concentrated into the weight of green tea 6 times it is spare.

The preparation of 2.11 emulsions

A) clean beaker is taken, snake oil 2g, olive oil 7g are weighed, composite emulsifying is added in this beaker in grape grape seed oil 4g Agent AC-4026g sets heating water bath on 80 DEG C of water-baths, as oily phase；

B) 9ml distilled water is measured, heating water bath on 80 DEG C of water-baths is set, as water phase；

C) it to oily mutually identical with water phase temperature, is mutually added to oily in water phase in thread shape, it is stirring while adding until being formed Uniform emulsion bases 1；

D) tuber of stemona extracting solution 5g, Radix Sophorae Flavescentis extractive liquid 3g, cortex phellodendri extract 2g, soapberry extract 3g, Radix Glycyrrhizae are weighed respectively Extracting solution 3g, frutus cnidii extracting solution 2g, wild chrysanthemum extracting solution 2g, peppermint extracting solution 4g, centella asiatica extract 3g, green tea extractive liquor 3g is uniformly mixed, as solution 1；

E) 2g sodium alginate is weighed, is dispensed into 60ml distilled water, coagulant liquid 1 is formed；

F) solution 1, coagulant liquid 1 are added in emulsion bases 1, are stirred, measure 5.34% ethylparaben alcohol Solution 3ml is added thereto, and is thoroughly mixed uniformly to get multi-functional except acarid emulsion.

Embodiment 3

Tuber of stemona extracting solution, Radix Sophorae Flavescentis extractive liquid, cortex phellodendri extract, soapberry extract, licorice extract, frutus cnidii extract The preparation of liquid, wild chrysanthemum extracting solution, peppermint extracting solution, centella asiatica extract, green tea extractive liquor is the same as embodiment 1, the preparation of emulsion It is as follows:

A) clean beaker is taken, snake oil 9g, olive oil 10g are weighed, Composite Milk is added in this beaker in grape grape seed oil 10g Agent AC-4026g sets heating water bath on 80 DEG C of water-baths, as oily phase；

B) 12ml distilled water is measured, heating water bath on 80 DEG C of water-baths is set, as water phase；

C) it to oily mutually identical with water phase temperature, is mutually added to oily in water phase in thread shape, it is stirring while adding until being formed Uniform emulsion bases 1；

D) tuber of stemona extracting solution 10g, Radix Sophorae Flavescentis extractive liquid 5g, cortex phellodendri extract 5g, soapberry extract 1g, Radix Glycyrrhizae are weighed respectively Extracting solution 1g, frutus cnidii extracting solution 4g, wild chrysanthemum extracting solution 2g, peppermint extracting solution 1g, centella asiatica extract 1g, green tea extractive liquor 1g is uniformly mixed, as solution 1；

E) 3g sodium alginate is weighed, is dispensed into 60ml distilled water, coagulant liquid 1 is formed；

F) solution 1, coagulant liquid 1 are added in emulsion bases 1, are stirred, measure 5.34% ethylparaben alcohol Solution 3ml is added thereto, and is thoroughly mixed uniformly to get multi-functional except acarid emulsion.

Test example

Physicochemical property detection is carried out to emulsion obtained by embodiment 1-3 respectively, as a result as follows:

1 character

Lotion made by the present invention whether be in it is faint yellow, viscosity is suitable for that fine and smooth uniformly stretchability is good, feels nice and cool and relaxes Suitable, stability is good.

2 pH value inspections

A small amount of lotion is dipped with the pH test paper of wetting, pH value can be directly used for skin whether between 6-7.

3 caloric tests

Lotion is packaged in transparence cosmetic bottle, in 4 DEG C of observations in refrigerator cold-storage one week or so, whether there is or not laminations.In In 55 DEG C of insulating box for 24 hours, phenomena such as lotion is without being layered, being spoiled.

4 centrifugal tests

Lotion is packaged in 3000r/min in tool plug test tube, is centrifuged 20min, no lamination.

5 irritation tests, anaphylaxis experiment

Shave off the hair about 2.5cm of rabbit back², rest for 24 hours, after the stimulation recovery from illness that shaving generates, take lotion 1.0g, uniformly It is coated on shaving position, is observed afterwards for 24 hours without rubescent, rash, bubble etc..Take lotion finished product 1g be applied to volunteer (20-60 years old, 15 People) gesture and facial expression on face, observed after 30 minutes, does not occur rubescent, dermexanthesis, foaming phenomena by mistake.

6 skin wrinkles are sturdy to be tested

The lotion of preparation is taken into 3g respectively, respectively plus distilled water 100ml, dilution are spare.The concentration of substances is stingless Swash property, selects intact no damaged skin to be placed on the gauze of 4 layers of 1cm using the lotion of preparation as reagent, be affixed on back or preceding Arm is bent on the healthy skin of side, and top is covered with a slightly larger cellophane cover, with adhesive plaster built-in edge.Simultaneously make it is multiple not Same trier, distance is greater than 4cm between every two, each object try has clearly mark and record.It is seen through negative control experiments Examine no allergic reaction phenomenon.

7 therapeutic effects

45 people of volunteer (15-25 years old) for choosing acarid serious symptom, is divided into three groups, every group of 15 people, by embodiment 1-3 institute Volunteer's skin that the lotion obtained is respectively used to three groups has at acarid symptom, and volunteer is generally comfortable on, and pruitus mitigates, Skin ingress of oil symptom, acne etc. subside.Continuous use through a period of time, situation caused by acarid are substantially reduced.

In conclusion the multi-functional lotion of the made treatment acarid of the invention can promote patient health to grow up, mite is reduced Skin lesion range caused by worm restores the normal barrier function of skin, perfect surface layer, the effective mite for reducing skin surface Worm has the effects that good antipruritic and whitening of deoiling.

Claims (2)

1. a kind of multi-functional except acarid emulsion, which is characterized in that be made of the raw material of following proportion:

The tuber of stemona extracting solution, Radix Sophorae Flavescentis extractive liquid, cortex phellodendri extract, soapberry extract, licorice extract, frutus cnidii extract Liquid, wild chrysanthemum extracting solution, peppermint extracting solution, centella asiatica extract, green tea extractive liquor are extracted by using distilled water, mistake Filter, is concentrated to get；The distilled water is extracted using refluxing extraction mode three times: adding distilled water immersion refluxing extraction 1- for the first time 2h, second plus distilled water refluxing extraction 0.5-1.5h, third time adds distilled water refluxing extraction 0.5-1.5h；It is described filtering be by Feed liquid after each refluxing extraction is filtered respectively, remerges gained filtrate three times.

2. the multi-functional preparation method except acarid emulsion described in claim 1, comprising the following steps:

A) clean beaker is taken, snake oil 1-9g, olive oil 1.5-10g, grape grape seed oil 1-12g are weighed, is added in this beaker multiple Co-emulsifier AC-402 2-7g, sets heating water bath on 60-88 DEG C of water-bath, as oily phase；

B) 4-9ml distilled water is measured, heating water bath on 60-88 DEG C of water-bath is set, as water phase；

C) it to oily mutually identical with water phase temperature, is mutually added to oily in water phase in thread shape, it is stirring while adding until being formed uniform Emulsion bases 1；

D) tuber of stemona extracting solution 2-12g, Radix Sophorae Flavescentis extractive liquid 1.3-6g, cortex phellodendri extract 1.3-6g, soapberry extract are weighed respectively 0.4-4g, licorice extract 0.4-4g, frutus cnidii extracting solution 0.7-5g, wild chrysanthemum extracting solution 0.5-3g, peppermint extracting solution 0.6- 4.5g, centella asiatica extract 0.3-3.5g, green tea extractive liquor 0.4-3g are uniformly mixed, as solution 1；

E) 0.5-4g sodium alginate is weighed, is dispensed into 30-70ml distilled water, coagulant liquid 1 is formed；

F) solution 1, coagulant liquid 1 are added in emulsion bases 1, are stirred, measure 5%-6% ethylparaben alcoholic solution 1-4ml is added thereto, be thoroughly mixed uniformly to get.