CN105194055A - Traditional Chinese medicine for treating cerebral thrombosis and preparation method of traditional Chinese medicine - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating cerebral thrombosis and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from the following raw medicinal materials: franchet peashrub flower root, rex woodbetony, salvia, pseudotinctorial indigo root, stem and leaf of hookedhairypod tickclover, gordon euryale leaf, aleuritopteris farinose free, small bugbane rhizome, root of whorlleat litse, saposhnikovia flower, wrightia religiosa root or stem and root of useful viburnum. The traditional Chinese medicine disclosed by the invention has a definite curative effect for the cerebral thrombosis, and is small in toxic or side effects.

Description

A kind of Chinese medicine and preparation method for the treatment of cerebral thrombosis

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of cerebral thrombosis.

Background technology

Cerebral thrombosis refers to the atherosis and thrombosis of Arterial system owing to supplying brain, makes that arterial lumen is narrow, obturation causes acute brain blood supply insufficiency, and causes a kind of acute cerebrovascular disease of local brain tissue necrosis.Main manifestations is the acute focal neurological deficit such as hemiplegia, aphasia of burst clinically.

Cerebral thrombosis belongs to Chinese medicine apoplexy category, and patient mostly is middle-aged and elderly people, and pathogenesis is that deficiency in origin table is real, and vigour virtual loss, the deficiency of vital energy is run unable, and expectorant is turbid, blood stasis is tied mutually, internal resistance venation, and QI-blood circulation is obstructed, and limbs muscle arteries and veins loses in moistening foster.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of Chinese medicine and preparation method for the treatment of cerebral thrombosis, Chinese medicine of the present invention has definite curative effect to cerebral thrombosis, and toxic and side effects is little.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of cerebral thrombosis, its raw medicinal material comprises: Radix Caraganae Franchetianae, Pedicularis rex C. B. Clarke ex Maxim., and red palpus must, Radix indigoferae Pseudotinctoriae, Caulis et Folium Desmodii Gangetici, Folium Euryales, water wolf beanstalk, Rhizoma Cimicifugae Acerinae, Radix litseae verticillatae, Flos Sapshnikoviae, Radix seu caulis wrightiae pubescentis and Radix Viburni Utilis.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Radix Caraganae Franchetianae 30 ~ 40 parts, Pedicularis rex C. B. Clarke ex Maxim. 50 ~ 60 parts, red palpus palpus 10 ~ 20 parts, Radix indigoferae Pseudotinctoriae 20 ~ 30 parts, Caulis et Folium Desmodii Gangetici 10 ~ 20 parts, Folium Euryales 5 ~ 15 parts, water wolf beanstalk 30 ~ 40 parts, Rhizoma Cimicifugae Acerinae 5 ~ 15 parts, Radix litseae verticillatae 50 ~ 60 parts, Flos Sapshnikoviae 5 ~ 15 parts, Radix seu caulis wrightiae pubescentis 10 ~ 20 parts and Radix Viburni Utilis 20 ~ 30 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Caraganae Franchetianae 30 ~ 35 parts, Pedicularis rex C. B. Clarke ex Maxim. 50 ~ 55 parts, red palpus palpus 10 ~ 15 parts, Radix indigoferae Pseudotinctoriae 20 ~ 25 parts, Caulis et Folium Desmodii Gangetici 10 ~ 15 parts, Folium Euryales 5 ~ 10 parts, water wolf beanstalk 30 ~ 35 parts, Rhizoma Cimicifugae Acerinae 5 ~ 10 parts, Radix litseae verticillatae 50 ~ 55 parts, Flos Sapshnikoviae 5 ~ 10 parts, Radix seu caulis wrightiae pubescentis 10 ~ 15 parts and Radix Viburni Utilis 20 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Caraganae Franchetianae 33 parts, Pedicularis rex C. B. Clarke ex Maxim. 54 parts, red palpus palpus 11 parts, Radix indigoferae Pseudotinctoriae 22 parts, Caulis et Folium Desmodii Gangetici 14 parts, Folium Euryales 6 parts, water wolf beanstalk 31 parts, Rhizoma Cimicifugae Acerinae 8 parts, Radix litseae verticillatae 52 parts, Flos Sapshnikoviae 7 parts, Radix seu caulis wrightiae pubescentis 13 parts and Radix Viburni Utilis 24 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 100 ~ 200 object micropowders;

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the starch of 0.2 ~ 0.4 times, the magnesium stearate of 0.003 ~ 0.03 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 85% ~ 95%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 1 hour ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;

Second step: the dry powder of acquisition is added the water dissolution relative to mixture quality 4 ~ 6 times, by 50% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.2%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.

Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to cerebral thrombosis, and toxic and side effects is little.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of cerebral thrombosis, its raw medicinal material comprises: Radix Caraganae Franchetianae, Pedicularis rex C. B. Clarke ex Maxim., red palpus palpus, Radix indigoferae Pseudotinctoriae, Caulis et Folium Desmodii Gangetici, Folium Euryales, water wolf beanstalk, Rhizoma Cimicifugae Acerinae, Radix litseae verticillatae, Flos Sapshnikoviae, Radix seu caulis wrightiae pubescentis and Radix Viburni Utilis.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Radix Caraganae Franchetianae: [source] is the root of leguminous plant Yunnan caragana.[nature and flavor] property is put down, sweet in the mouth, micro-hardship.[function cures mainly] expelling wind and activating blood circulation, pain relieving, diuresis, QI invigorating kidney tonifying.Treating rheumatic arthritis, traumatic injury, galactopoiesis is not enough, edema, dysmenorrhea.

Pedicularis rex C. B. Clarke ex Maxim.: [source] is the root of goatweed Pedicularis rex.[nature and flavor] taste is micro-sweet, cool in nature.[return through] returns liver, spleen channel.[function cures mainly] invigorating qi and benefiting blood, invigorating spleen to remove dampness.Main deficiency of YIN hectic fever, puerperal hypogalactia, chronic hepatitis, cirrhotic ascites, infantile malnutrition.

Red palpus palpus: [source] is the root of labiate Salvia lankongensis C. Y. Wu..[nature and flavor] bitter in the mouth, cold nature.[return through] returns liver, heart channel.[function cures mainly] promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing.Main menoxenia, dysmenorrhea, amenorrhea, ectopic pregnancy, hepatosplenomegaly, thoracic obstruction angor, dysphoria and insomnia, sore and toxic.

Radix indigoferae Pseudotinctoriae: [source] is the root of leguminous plant horse sour jujube.[nature and flavor] are warm in nature, and bitter in the mouth is puckery.[return through] GUIXIN, Liver Channel.[function cures mainly] blood circulation promoting and blood stasis dispelling, removing toxic substances.Main cough with asthma, larynx pretty young woman, furuncle, scrofula, hemorrhoid, traumatic injury.

Caulis et Folium Desmodii Gangetici: [source] is the herb of leguminous plant great Ye Desmodium racemosum Thunb..[nature and flavor] are sweet, pungent, flat.[return through] returns Liver Channel.The regulating menstruation of [function cures mainly] blood stasis dispelling, removing toxic substances pain relieving.Main traumatic injury, uterine prolapse, proctoptosis, amenorrhea, psoriasis, toothache, headache.

Folium Euryales: [source] is the leaf of nymphaeaceae plant Gorgon euryale.[nature and flavor] are bitter, pungent, flat.[return through] returns liver, kidney channel.[function cures mainly] promoting flow of QI and blood, hemostasis by removing blood stasis.Main haematemesis, has blood in stool, women's retention of placenta in puerperal.

Water wolf beanstalk: [source] is the herb of Sinopteridaceae plant Aleuritopteris farinsa (Forsk.) Fee.[nature and flavor] are bitter, micro-puckery, temperature.[function cures mainly] relieving cough and resolving phlegm, the spleen strengthening and damp drying, blood circulation promoting and blood stasis dispelling.Main acute/chronic bronchitis, pertussis, dyspepsia, dysentery, stomachache, leucorrhea, traumatic injury.

Rhizoma Cimicifugae Acerinae: [source] is the rhizome of ranunculaceae plant Gold Testudinis grass.[nature and flavor] sweet in the mouth is bitter, cold in nature.[function cures mainly] heat clearing away, invigorates blood circulation, removing toxic substances.Control pharyngodynia with dryness, traumatic injury, strain, lumbago, skelalgia of rheumatism, furuncle and phyma.

Radix litseae verticillatae: the stem and leaf that [source] is canella wheel blade Fructus Litseae pungentis or root.[nature and flavor] are bitter, pungent, temperature.[return through] returns lung, Liver Channel.[function cures mainly] dispelling wind and removing obstruction in the collateral, promoting blood circulation and detumescence, pain relieving.Main air wet arthritis, lumbago and skelalgia, quadriplegia, dysmenorrhea, treating swelling and pain by traumatic injury.

Flos Sapshnikoviae: the flower that [source] is umbelliferae Saposhnikovia divaricata.[nature and flavor] acrid in the mouth, slightly warm in nature.[return through] returns spleen, stomach, Liver Channel.The pain relieving of [function cures mainly] regulating qi and dredging collateral.Main abdominal pain, spasm of the limbs, arthralgia.

Radix seu caulis wrightiae pubescentis: [source] hangs upside down root or the stem branch of pen for apocynaceae plant.[nature and flavor] are sweet, light, and property is put down.[function cures mainly] dispelling wind and removing obstruction in the collateral, dissipating phlegm and resolving masses, dampness removing.Main air pain of dampness syndrome, lumbocrural pain, traumatic injury, scrofula, chronic bronchitis, icterohepatitis, cirrhotic ascites.

Radix Viburni Utilis: [source] is the root of caprifoliaceae plant smoke pipe Caulis Viburni Dilatati.[nature and flavor] bitter in the mouth, puckery, property is put down.[function cures mainly] eliminating damp, detoxifying, promoting blood circulation to remove obstruction in the collateral.Main dysentery, proctoptosis, hemorrhoid hematochezia, leucorrhea, rheumatic arthralgia, traumatic injury, carbuncle, eczema.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Radix Caraganae Franchetianae 30 ~ 40 parts, Pedicularis rex C. B. Clarke ex Maxim. 50 ~ 60 parts, red palpus palpus 10 ~ 20 parts, Radix indigoferae Pseudotinctoriae 20 ~ 30 parts, Caulis et Folium Desmodii Gangetici 10 ~ 20 parts, Folium Euryales 5 ~ 15 parts, water wolf beanstalk 30 ~ 40 parts, Rhizoma Cimicifugae Acerinae 5 ~ 15 parts, Radix litseae verticillatae 50 ~ 60 parts, Flos Sapshnikoviae 5 ~ 15 parts, Radix seu caulis wrightiae pubescentis 10 ~ 20 parts and Radix Viburni Utilis 20 ~ 30 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Caraganae Franchetianae 30 ~ 35 parts, Pedicularis rex C. B. Clarke ex Maxim. 50 ~ 55 parts, red palpus palpus 10 ~ 15 parts, Radix indigoferae Pseudotinctoriae 20 ~ 25 parts, Caulis et Folium Desmodii Gangetici 10 ~ 15 parts, Folium Euryales 5 ~ 10 parts, water wolf beanstalk 30 ~ 35 parts, Rhizoma Cimicifugae Acerinae 5 ~ 10 parts, Radix litseae verticillatae 50 ~ 55 parts, Flos Sapshnikoviae 5 ~ 10 parts, Radix seu caulis wrightiae pubescentis 10 ~ 15 parts and Radix Viburni Utilis 20 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Caraganae Franchetianae 33 parts, Pedicularis rex C. B. Clarke ex Maxim. 54 parts, red palpus palpus 11 parts, Radix indigoferae Pseudotinctoriae 22 parts, Caulis et Folium Desmodii Gangetici 14 parts, Folium Euryales 6 parts, water wolf beanstalk 31 parts, Rhizoma Cimicifugae Acerinae 8 parts, Radix litseae verticillatae 52 parts, Flos Sapshnikoviae 7 parts, Radix seu caulis wrightiae pubescentis 13 parts and Radix Viburni Utilis 24 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 100 ~ 200 object micropowders;

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the starch of 0.2 ~ 0.4 times, the magnesium stearate of 0.003 ~ 0.03 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 85% ~ 95%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 1 hour ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;

Second step: the dry powder of acquisition is added the water dissolution relative to mixture quality 4 ~ 6 times, by 50% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.2%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: capsule

Get Radix Caraganae Franchetianae 330g, Pedicularis rex C. B. Clarke ex Maxim. 540g, red palpus palpus 110g, Radix indigoferae Pseudotinctoriae 220g, Caulis et Folium Desmodii Gangetici 140g, Folium Euryales 60g, water wolf beanstalk 310g, Rhizoma Cimicifugae Acerinae 80g, Radix litseae verticillatae 520g, Flos Sapshnikoviae 70g, Radix seu caulis wrightiae pubescentis 130g and Radix Viburni Utilis 240g;

Prepare according to the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 80%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize and sieve acquisition 200 object micropowders;

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.35 times, the starch of 0.4 times, the magnesium stearate of 0.02 times, carry out mixing process, namely obtain capsule 's content, described Capsule content is incapsulated in housing, namely obtain capsule finished product.

Embodiment 2: syrup

Get Radix Caraganae Franchetianae 310g, Pedicularis rex C. B. Clarke ex Maxim. 520g, red palpus palpus 140g, Radix indigoferae Pseudotinctoriae 230g, Caulis et Folium Desmodii Gangetici 110g, Folium Euryales 90g, water wolf beanstalk 330g, Rhizoma Cimicifugae Acerinae 70g, Radix litseae verticillatae 530g, Flos Sapshnikoviae 80g, Radix seu caulis wrightiae pubescentis 120g and Radix Viburni Utilis 220g;

Prepare according to the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 times, mixture is the ethanol of 95%, heating and refluxing extraction 4 times, each reflux, extract, 1 hour, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.08, by dry with spray dryer for the concentrated solution after concentrated, be ground into 200 orders subsequently, obtain dry powder;

Second step: the dry powder of acquisition is added the water dissolution relative to mixture quality 5 times, by 50% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 50%, ethyl hydroxybenzoate 0.03%.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 25-35g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 8.48g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>42.4 crude drug/kg of the present invention, every day, maximum dosage-feeding was 84.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.14g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 30g) oral administration gavage Chinese medicine of the present invention is 606 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention to three groups of mices (often organize 20) by 13.88,22.32 and 43.56g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 92 routine cases are my Out-patient Department patient of in November, 2012 ~ 2014 year October, and all patients all make a definite diagnosis cerebral thrombosis.Patient is divided into treatment group and matched group at random, wherein treatment group 50 example, male 30 example, women 20 example.55 ~ 80 years old age, the course of disease 1 ~ 7 day; Matched group 42 people, male 27 example, women 15 example.53 ~ 80 years old age, the course of disease 1 ~ 7 day.Two groups in age, the course of disease, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).

Diagnostic criteria: draft diagnostic criteria by the 4th national cerebrovascular academic conference in October nineteen ninety-five.Cerebral thrombosis is turned out to be through head Cr or MRI.

Therapeutic Method:

Matched group: simultaneously take enteric solubility aspirin 50mgqd, nimodipine 20mgtid, piracetam 0.8gtid, VitE100mgtid.30 days 1 courses for the treatment of, totally 2 courses for the treatment of.

Treatment group: oral Chinese medicine embodiment 1 capsule 4 of the present invention, every day 3 times.30 days 1 courses for the treatment of, totally 2 courses for the treatment of.

Curative effect judging standard: substantially cure: consciousness recovery is normal, Myodynamia recovery IV ~ V grade, life can be taken care of oneself.Effective: consciousness recovery is normal, and muscular strength improves more than II grade, life is taken care of oneself substantially.Effective: consciousness recovery is normal, and muscular strength improves II grade, can't take care of oneself.Invalid: after treatment, symptom is without improvement.

Therapeutic outcome:

Group	n	Basic healing	Effective	Effectively	Invalid	Effectively total
							Treatment group	50	17	16	11	6	44(88.00％)
Matched group	42	10	9	11	12	30(71.43％)

Treatment group and matched group comparitive study, treatment group is better than matched group, two groups of variant statistical significances (P<0.05) of curative effect.

Concrete case: the Qin, man, 63 years old.The left hemianesthesia of patient is meciless, and dysfunction is walked with difficulty, crooked with bicker curtain coating, and dysphonia, is diagnosed as cerebral thrombosis through head B-sonography.Give each 4 of Chinese medicine embodiment 1 capsule of the present invention, every day 3 times, 30 days 1 courses for the treatment of.After treating 2 courses for the treatment of, substantially cure.Follow up a case by regular visits to and do not recur half a year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. treat a Chinese medicine for cerebral thrombosis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Radix Caraganae Franchetianae, Pedicularis rex C. B. Clarke ex Maxim., and red palpus must, Radix indigoferae Pseudotinctoriae, Caulis et Folium Desmodii Gangetici, Folium Euryales, water wolf beanstalk, Rhizoma Cimicifugae Acerinae, Radix litseae verticillatae, Flos Sapshnikoviae, Radix seu caulis wrightiae pubescentis and Radix Viburni Utilis.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Caraganae Franchetianae 30 ~ 40 parts, Pedicularis rex C. B. Clarke ex Maxim. 50 ~ 60 parts, red palpus palpus 10 ~ 20 parts, Radix indigoferae Pseudotinctoriae 20 ~ 30 parts, Caulis et Folium Desmodii Gangetici 10 ~ 20 parts, Folium Euryales 5 ~ 15 parts, water wolf beanstalk 30 ~ 40 parts, Rhizoma Cimicifugae Acerinae 5 ~ 15 parts, Radix litseae verticillatae 50 ~ 60 parts, Flos Sapshnikoviae 5 ~ 15 parts, Radix seu caulis wrightiae pubescentis 10 ~ 20 parts and Radix Viburni Utilis 20 ~ 30 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Caraganae Franchetianae 30 ~ 35 parts, Pedicularis rex C. B. Clarke ex Maxim. 50 ~ 55 parts, red palpus palpus 10 ~ 15 parts, Radix indigoferae Pseudotinctoriae 20 ~ 25 parts, Caulis et Folium Desmodii Gangetici 10 ~ 15 parts, Folium Euryales 5 ~ 10 parts, water wolf beanstalk 30 ~ 35 parts, Rhizoma Cimicifugae Acerinae 5 ~ 10 parts, Radix litseae verticillatae 50 ~ 55 parts, Flos Sapshnikoviae 5 ~ 10 parts, Radix seu caulis wrightiae pubescentis 10 ~ 15 parts and Radix Viburni Utilis 20 ~ 25 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Caraganae Franchetianae 33 parts, Pedicularis rex C. B. Clarke ex Maxim. 54 parts, red palpus palpus 11 parts, Radix indigoferae Pseudotinctoriae 22 parts, Caulis et Folium Desmodii Gangetici 14 parts, Folium Euryales 6 parts, water wolf beanstalk 31 parts, Rhizoma Cimicifugae Acerinae 8 parts, Radix litseae verticillatae 52 parts, Flos Sapshnikoviae 7 parts, Radix seu caulis wrightiae pubescentis 13 parts and Radix Viburni Utilis 24 parts.

5. the Chinese medicine as described in Claims 1-4, it is characterized in that, the dosage form of described Chinese medicine is capsule, its first step processed: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 100 ~ 200 object micropowders;

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the starch of 0.2 ~ 0.4 times, the magnesium stearate of 0.003 ~ 0.03 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.

6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 85% ~ 95%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 1 hour ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;

Second step: the dry powder of acquisition is added the water dissolution relative to mixture quality 4 ~ 6 times, by 50% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.2%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.

7. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 100 ~ 200 object micropowders;

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the starch of 0.2 ~ 0.4 times, the magnesium stearate of 0.003 ~ 0.03 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.

8. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 85% ~ 95%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 1 hour ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;

Second step: the dry powder of acquisition is added the water dissolution relative to mixture quality 4 ~ 6 times, by 50% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.2%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.