CN105193959A - Traditional Chinese medicine preparation for preventing and treating bone tuberculosis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for preventing and treating bone tuberculosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for preventing and treating bone tuberculosis. The traditional Chinese medicine preparation is prepared from the following raw medicinal materials in parts by weight: 6-12 parts of Chinese caterpillar fungus, 8-13 parts of Chinese elder herb, 10-14 parts of ginseng flower, 7-15 parts of twig and leaf of creeping psychotria, 9-14 parts of herb of siberian sealavender, 8-16 parts of Japanese honeysuckle stem, 7-12 parts of root of wingedstem inula, 10-15 parts of root or stem of smallflower embelia, 8-14 parts of root of berry-bearing campion, 11-16 parts of herb of ramose scouring rush, 9-15 parts of bark of manchurian walnut, 8-12 parts of common fenugreek seed, 9-13 parts of rhizome of leatherleaf knotweed and 8-15 parts of Chinese sage herb. The traditional Chinese medicine preparation disclosed by the invention has the good effects that the formula is precise in compatibility and quick in curative effect, has the effects of warming cold-damp, breaking stagnated blood to dredge collaterals, dispersing blood stasis to promote tissue regeneration, promoting growth of new femora, and improving functions of joints, and has broad-spectrum practicability.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preparation and method for making of preventing and treating bone tuberculosis.
Background technology
Bone tuberculosis is the destructive pathological changes caused by tubercule bacillus intrusion bone or joint.Site of pathological change is most in large, movable many, that strain easily occurs bone or the joint of bearing a heavy burden.Most predilection site is spinal column, is secondly hip, knee joint, foot, elbow, hands etc.Bone tuberculosis is mostly by pulmonary tuberculosis secondary.But also there is patient there is no pulmonary tuberculosis medical history, belong to the Invisible infection of tulase.First tuberculosis sclerotium occurs in pulmonary mostly, can be gone, can cause skeletal system tuberculosis, tuberculosis of urinary system, tuberculosis of digestive system etc. after pulmonary infection by the propagation of blood to a lot of system of whole body.So bone tuberculosis is not simple pathological changes, be the performance of general disease in local.Some bone tuberculosis even can cause patient to paralyse, and this is because tuberculosis is to the erosion of bone, once spinal cord is oppressed or damaged and tractive, pass on instruction to go wrong, patient just there will be paralysis.
Bone tuberculosis disease is called as " bone tuberculosis " or " tuberculosis of bone and joint " in tcm theory, belongs to the one of YIN syndrome, and motherland's medical science thinks that " bone tuberculosis " is because the positive deficiency of vital energy is lost, muscles and bones trauma, and qi-blood disharmony, storing knot stasis of blood dimerization is that expectorant is turbid, multiple abscess skeletal joint and sending out.Because the onset speed of this disease is slow, Symptoms is very hidden, and the commitment occurred in the state of an illness is not easily found.Once there is obviously Symptoms, the state of an illness has developed into the middle and advanced stage stage under normal circumstances, and most of patients has cold abscess and can wear out skin and occurs, and then forms sinus tract, causes serious destruction, and then cause deformity in various degree to osteoarthrosis.
Application publication number CN102293974A(application number 201110250840.X) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of bone tuberculosis, be made up of the raw material of following parts by weight: Carapax Trionycis 500-530; Rhizoma Atractylodis Macrocephalae 450-480; Radix Platycodonis 300-400; Fry Squama Manis 100-120; Scorpio 100-120; Radix Stemonae 1500-2000; Bulbus Fritillariae Cirrhosae 500-560; Pseudobulbus Bletillae (Rhizoma Bletillae) 2000-2500; Rhizoma Pinelliae 300-320; Rhizoma Picrorhizae 450-500; Radix Stellariae 450-500; Scolopendra 50-60; Large Gecko 100-120; Radix Glycyrrhizae 300-350; Mel 10000-13000.Application publication number CN103845443A(application number 201210543519.5) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of bone tuberculosis, be made up of the raw material of following weight proportion: raw Carapax et Plastrum Testudinis 1500-1700 gram, Radix Astragali 15-25 gram, Rhizoma Coptidis 15-25 gram, Fructus Jujubae 1500-1700 gram.Application publication number CN103860765A(application number 201410094808.0) Chinese invention patent document disclose a kind of Chinese medicinal liquor for the treatment of bone tuberculosis and preparation method thereof, , be made up of the raw material of following weight portion: Spina Gleditsiae 18-22 gram, Semen Strychni 18-22 gram, Scolopendra 18-22 gram, Radix Aconiti Lateralis Preparata 13-17 gram, Cera Flava 13-17 gram, Radix Angelicae Sinensis 13-17 gram, Radix Rehmanniae Preparata 13-17 gram, Radix Ginseng Rubra 9-11 gram, Zaocys 9-11 gram, Radix Bupleuri 9-11 gram, Radix Rubiae 9-11 gram, Rhizoma Et Radix Notopterygii 9-11 gram, Cornu Cervi Pantotrichum 6-8 gram, Fructus Crotonis 6-8 gram, Cortex Eucommiae 6-8 gram, Cortex Lycii 2-4 gram, Ramulus Uncariae Cum Uncis 2-4 gram, Radix Achyranthis Bidentatae 2-4 gram, Fructus Chaenomelis 2-4 gram, more than 55 degree Chinese liquor 4500-5500 gram.
Although current western medical treatment takes effect obviously, also temporary transient problem can only be solved, simultaneously also larger on Liver and kidney function impact.Operative treatment easily recurs, therefore operative treatment and western medicine and medical practitioners treatment all can not reach desirable effect.Therefore, there is very large demand to the Chinese medicine of effectively treating bone tuberculosis in people.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, easily the pouring of clothes prevents and treats Chinese medicine preparation and the preparation method of bone tuberculosis for a long time.This Chinese medicine preparation determined curative effect and having no side effect.
Technical scheme of the present invention is:
Prevent and treat a Chinese medicine preparation for bone tuberculosis, be prepared from by following bulk drugs, be weight portion: Cordyceps 6-12; Herba Sambuci Chiensis 8-13; Flos Ginseng 10-14; Ramulus et Folium Psychotriae Serpentis 7-15; Herba Limonii Gmelinii 9-14; Caulis Lonicerae 8-16; Radix Inulae Pterocaulae 7-12; Radix seu Caulis Embeliae Parviflorae 10-15; Radix Cucubali 8-14; Herba equiseti ramosissimi 11-16; Cortex Juglandis mandshuricae 9-15; Semen Trigonellae 8-12; Rhizoma Polygoni coriacei 9-13; Herba Salviae Chinensis 8-15.
In preferred scheme, Cordyceps 8-10; Herba Sambuci Chiensis 9.5-11.5; Flos Ginseng 11-13; Ramulus et Folium Psychotriae Serpentis 9-13; Herba Limonii Gmelinii 11-12; Caulis Lonicerae 10-14; Radix Inulae Pterocaulae 9-10; Radix seu Caulis Embeliae Parviflorae 11-14; Radix Cucubali 10-12; Herba equiseti ramosissimi 12.5-14.5; Cortex Juglandis mandshuricae 11-13; Semen Trigonellae 9-11; Rhizoma Polygoni coriacei 10-12; Herba Salviae Chinensis 10-13.
Be more preferably, Cordyceps 9; Herba Sambuci Chiensis 10.5; Flos Ginseng 12; Ramulus et Folium Psychotriae Serpentis 11; Herba Limonii Gmelinii 11.5; Caulis Lonicerae 12; Radix Inulae Pterocaulae 9.5; Radix seu Caulis Embeliae Parviflorae 12.5; Radix Cucubali 11; Herba equiseti ramosissimi 13.5; Cortex Juglandis mandshuricae 12; Semen Trigonellae 10; Rhizoma Polygoni coriacei 11; Herba Salviae Chinensis 11.5.
Prevent and treat a Chinese medicine preparation for bone tuberculosis, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) Cordyceps and Semen Trigonellae are together placed in pulverizer and clay into power, for subsequent use;
(2) Herba Sambuci Chiensis, Ramulus et Folium Psychotriae Serpentis, Caulis Lonicerae and Herba equiseti ramosissimi are mixed, add vinegar and mix thoroughly, steam to well-done, take out, mash, fully, put in parch container, slow fire fried dry, cools, for subsequent use in grinding;
(3) by Flos Ginseng and Herba Salviae Chinensis mixing, the Mel adding 0.12-0.18 times amount is mixed thoroughly (Mel preferably adding 0.15 times amount is mixed thoroughly), and it is degree that slow fire is fried extremely tack-free, takes out dry, smashs into fine powder to pieces, for subsequent use;
(4) by Herba Limonii Gmelinii, Radix Inulae Pterocaulae, Radix seu Caulis Embeliae Parviflorae, Rhizoma Polygoni coriacei, Radix Cucubali and Cortex Juglandis mandshuricae in medicine pot, add clear water and soak 2-4 hour (preferably add clear water and soak 3 hours), then big fire is heated to boil, turn little fire to decoct slowly 23-45 minute (preferably turn little fire and decoct 34 minutes slowly), filter, medicinal residues add the clear water (preferred medicinal residues add the clear water of 5 times amount again) of 3.5-6.5 times amount again, slow fire boiling 18 minutes, filter, merge twice filtrate, being evaporated to 80 DEG C of relative densities is the thick paste of 1.20-1.23, vacuum drying, get dry extract powder, for subsequent use;
(5) the raw material medicated powder mixing after step (1)-(4) being processed, add magnesium stearate and sucrose fine (raw material medicated powder: magnesium stearate: sucrose fine=4:0.3:0.7), stir, cross 115-145 mesh sieve (preferred mistake 130 mesh sieve), be processed into tablet, obtain final product.
Above-mentioned a kind of preparation method of preventing and treating the Chinese medicinal tablet of bone tuberculosis, preferred scheme is, in step (2), the amount of vinegar is the 0.18-0.34 of raw material dose doubly (amount of preferred vinegar is 0.22-0.30 times of raw material dose, and the amount of the vinegar be more preferably is 0.26 times of raw material dose).
Above-mentioned a kind of preparation method of preventing and treating the Chinese medicinal tablet of bone tuberculosis, preferred scheme is, in step (4), the amount of clear water is the 6-9 of raw material dose doubly (amount of preferred clear water is 7-8 times of raw material dose, and the amount of the clear water be more preferably is 7.5 times of raw material dose).
The preparation method of described powder is:
(1) Cordyceps is placed in pulverizer and clays into power, for subsequent use;
(2) be together placed in parch container by Herba Limonii Gmelinii, Radix Inulae Pterocaulae, Radix seu Caulis Embeliae Parviflorae, Radix Cucubali and Cortex Juglandis mandshuricae, slow fire heats, with stir-fry with spray yellow wine, when yellow wine is exhausted completely by medical material, then slow fire stir-fries to medical material surface in yellow slightly focal spot, and taking-up cools, smash into fine powder to pieces, for subsequent use;
(3) crude drug except step (1) and (2) is mixed, fully dry, pulverize into fine powder, crude drug after processing with step (1) and (2) mixes, and 78-102 DEG C of dry heat sterilization 20 minutes (preferably 90 DEG C dry heat sterilization 20 minutes), is cooled to room temperature, encapsulation, to obtain final product.
Above-mentioned a kind of preparation method of preventing and treating the Chinese powder medicine of bone tuberculosis, preferred scheme is, the mass ratio of step (2) Raw medicine and yellow wine is the mass ratio of the preferred crude drug of 8:0.8-1.2(and yellow wine is 8:0.9-1.1, and the crude drug be more preferably and the mass ratio of yellow wine are 8:1)
The preparation method of described decoction is:
(1) Cordyceps and Flos Ginseng are cleaned respectively, be placed in medicine pot, add the pure water (preferably adding the pure water of 3.5 times amount) of 2.5-4.5 times amount, slow fire heating decocts 6-10 minute (preferred slow fire heating decoction 8 minutes), when medicinal liquid darkens, stop heating, filter, filtrate and medicinal residues for subsequent use;
(2) by Herba Sambuci Chiensis, Caulis Lonicerae, Ramulus et Folium Psychotriae Serpentis, Herba equiseti ramosissimi and Herba Salviae Chinensis mix, add mass fraction be 11% Sucus Zingberis and mass fraction be the saline solution of 3.5%, mix thoroughly, stewing 12-20 minute (preferably stewing 16 minutes), be then placed in hot pot, slow fire dries, be ground into fine powder, for subsequent use;
(3) be placed in medicine pot by Semen Trigonellae, Cortex Juglandis mandshuricae and Radix Inulae Pterocaulae, it is dark brown that slow fire is heated to medical material, takes out, is ground into fine powder, mixes with step (2) gained fine powder, crosses 140-180 mesh sieve (preferred mistake 160 mesh sieve), obtains mixed powder, for subsequent use;
(4) Herba Limonii Gmelinii, Radix seu Caulis Embeliae Parviflorae, Rhizoma Polygoni coriacei and Radix Cucubali are placed in medicine pot, add pure water and do not have powder 2-4cm, then slow fire is decocted 35-55 minute (preferably then slow fire decocts 45 minutes slowly) slowly, filter, medicinal residues mix with step (1) gained medicinal residues, continue the pure water (preferably continuing to add the pure water of 5 times amount) adding 3.5-6.5 times amount, slow fire boiling 8-16 minute (preferred slow fire boiling 12 minutes), filter, filtrate reduced in volume is to the half of original volume, for subsequent use;
(5) step (1) gained filtrate and step (3) gained mixed powder are joined in above-mentioned filtrate, stir, sterilizing encapsulates, and to obtain final product.
The preparation method of described capsule is:
(1) be placed in by Semen Trigonellae in hot pot, slow fire roasting to surface is buff slightly focal spot, slightly cool, is together placed in pulverizer clays into power with Cordyceps, for subsequent use;
(2) Flos Ginseng, Herba equiseti ramosissimi and Ramulus et Folium Psychotriae Serpentis are placed in hot sand, scald to medical material surface slightly black focal spot, take out, grind to form fine powder, for subsequent use;
(3) crude drug except step (1) and (2) is placed in frying pan, adds clear water and do not have medical material surface, slow fire boiling twice, each respectively decoction 24-40 minute (preferably each each decoction 32 minutes), filter, filtrate reduced in volume to 75 DEG C relative density is the clear paste of 1.18-1.20, for subsequent use;
(4) by step (1) and the mixing of (2) gained medicated powder, cross 75-115 mesh sieve (preferred mistake 95 mesh sieve), join in step (3) gained clear paste, add while stirring mass fraction be 1.1% microcrystalline Cellulose and mass fraction be the corn starch of 3.7%, stir, granulate, dry, incapsulate shell, to obtain final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Cordyceps: base is former: be the larva cadaveric complex of the Stroma and host's Hepialidae insecticide Hepialus etc. thereof of Clavicipitaceae plant Cordyceps fungus.Chemical analysis: moisture content 10.84%, fat 8.4%, crude protein 25.32%, crude fibre 18.53%, carbohydrate 28.90%, ash 4.10％。Fat is containing satisfied fatty acid 13.00%, unsaturated fatty acid 82.2％。Nature and flavor: sweet, temperature.Gui Jing: " book on Chinese herbal medicine is new again ": " enter lung, kidney two warp." function cures mainly: tonifying deficiency, beneficial vital essence, relieving cough and resolving phlegm.Control phlegm retention to breathe heavily and cough, dyspnea due to deficiency, consumptive disease is coughed, spitting of blood, spontaneous sweating, impotence and seminal emission, soreness of waist and knee joint, and prolonged deficiency is multiple after being ill.
Herba Sambuci Chiensis: base is former: be the stem and leaf of caprifoliaceae plant Herba Sambuci Chiensis.Chemical analysis: Herba Sambuci Chiensis herb contains flavonoid, phenolic constituent, tannin, saccharide, chlorogenic acid, seed cyanogenetic glycoside class.Pharmacological action: 1.Analgesia: Herba Sambuci Chiensis decoct 70,120,140g/kg gavages, show there is analgesic activity to hot plate method in mice test, its analgesic composition Half-life in vivo is 3.9h。2。Anti-liver injury: Herba Sambuci Chiensis composition ursolic acid 100mg/kg subcutaneous injection, has protective effect to Rat Experimental hepatic injury, makes content of triglyceride in liver reduce, and alleviates hepatocellular degeneration and necrosis.3。Other effects: decoct 5g/kg gavage, and adjust external application with wine, to Experimental Fracture rabbit, there is promoting blood circulation to remove blood stasis, increase the absorption of phosphorus, promote the effect that callus is ossified.Nature and flavor: sweet in the mouth; Micro-hardship; Property is put down.Function cures mainly: dispel the wind; Dampness removing; Relaxing muscles and tendons; Invigorate blood circulation.Main air temperature arthralgia pain; Lumbago and skelalgia; Edema; Jaundice; Traumatic injury button damages; Disease that postpartum lochia can't go; Rubella pruritus; Erysipelas; Skin ulcer swells.
Flos Ginseng: base is former: be the inflorescence of Araliaceae Radix Ginseng.Pharmacological action: 1, have obvious Antishock function to the alabastrum of Radix Ginseng Saponin that affects of cardiovascular system, can reduce hemorrhagic shock too lactic dehydrogenase cruel (LDH), active, improves microcirculation because of the anaerobic environment [1] caused by ischemia; Also can reduce the hemorrhagic shock too content [2] of lipid peroxide (LPO) in the heart, liver, lung tissue.2, antiulcer action Ginseng Flower Saponin 60mg/kg intramuscular injection is to pylorus ligation, Experimental Gastric Ucler animal model caused by reserpine, aspirin all has inhibitory action, and obviously can suppress the activity of rat gastric secretion, reduction Both of gastric acidity and protease.To histamine and the rat that causes of phatidylcholine and guinea pig in vitro enterospasm shrink, also have partial agonistic effect [4].3, can to improve mice spleen spleen natural killer cell (NKC) active for the in vitro tests of antitumor action Ginseng Flower Saponin, and can at canavaline-A(Con-A) there is situation under induce biogamma (γ-IFN) and interleukin-2 (IL-2); The NKC that can improve normal mouse in vivo in test is active, and kind of the NKC planting tumor mice ability that is active, that produce γ-IFN and IL-2 can be made to be enhanced.
Ramulus et Folium Psychotriae Serpentis: base is former: for Maguireothamnus speciosus is crawled the branch of Psychotria rubra (Lour.) Poir., leaf or Herb.Chemical analysis: containing ursolic acid in Ramulus et Folium Psychotriae Serpentis, stigmasterol, cupreol, higher aliphatic ketone, tectoquinone etc.Pharmacological action: the ursolic acid proposed from Ramulus et Folium Psychotriae Serpentis herb is 6.6 μ g/ml to the ED50 of human nasopharyngeal carcinoma (KB) cell in vitro, be 4.0 μ g/ml to people pulmonary carcinoma A549ED50, being 4.5 μ g/ml to the ED50 of ileocecum cancer HCT-8, is 4.9 μ g/ml to the ED50 of breast carcinoma MCF-7.Nature and flavor: toil; Flat.Gui Jing: liver; Heart channel.Function cures mainly: wind-damp dispelling; Relaxing muscles and tendons and activating QI and blood in the collateral; Reducing swelling and alleviating pain.Main rheumatic arthritis; Numb hand and foot; Psoas muscle labor fingerprint; Sciatica; Multiple carbuncle; Bone tuberculosis; Traumatic injury; Fracture; Venom.
Herba Limonii Gmelinii: base is former: be the root of Plumbaginaceae plant Herba Limonii Gmelinii.Nature and flavor: bitter; Micro-salty; Cool in nature.Function cures mainly: heat clearing away; Dampness removing; Hemostasis; Removing toxic substances.Main hygropyretic hematochezia; Proctoptosis; Stranguria with blood; Menorrhagia, leucorrhea; Carbuncle sore tumefacting virus.
Caulis Lonicerae: base is former: be the stem and leaf of caprifoliaceae plant Radix Ophiopogonis.Chemical analysis: leaf is containing the flavonoid such as lonicerin and luteolin-7-scillabiose, luteolin.Stem is containing tannin, alkaloid.Pharmacological action: luteolin has spasmolysis to smooth muscle (rabbit residence body small intestinal), but not as good as papaverine; And have mild diuretic (increasing the discharge of sodium chloride) effect.Nature and flavor: sweet, cold.Gui Jing: enter the heart, lung meridian.Function cures mainly: heat clearing away, removing toxic substances, dredging collateral.Control epidemic febrile disease heating, toxic-heat and blood stasis, infectious hepatitis, carbuncle sore tumefacting virus, bones and muscles pain.
Radix Inulae Pterocaulae: base is former: be the root of feverfew wing stem Herba Inulae cappae.Nature and flavor: bitter in the mouth; Property is put down.Function cures mainly: tonify deficiency; Heat clearing away; Cough-relieving.Main body deadhead is swooned; Tinnitus; Nervous; Insomnia; Cold perspiration; Chronic cough of deficiency lung; Carbuncle and ulcer toxic swelling; Bone tuberculosis.
Radix seu Caulis Embeliae Parviflorae: base is former: be root or the rattan of Myrsinacea plant Embelia parviflora Wall.Nature and flavor: bitter; Puckery; Warm in nature.Gui Jing: liver; Kidney channel.Function cures mainly: enrich blood; Invigorate blood circulation; Strong waist knee joint.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Puerperal asthenia; Waist and leg ache; Injury and bone fracture.
Radix Cucubali: base is former: be the root of pinkwort Cucubalus baccifer.Chemical analysis: root, containing multiple oligosaccharide (three to eight monosaccharide composition), is all the galactoside of sucrose, in have lychnose, isolychnose and Raffinose; In addition, also containing sucrose.Seed contains the derivative saccharide of a small amount of lychnose and isolychnose.Nature and flavor: bitter light, cool.Gui Jing: liver; Spleen channel.Function cures mainly: removing heat from blood, invigorates blood circulation, dampness removing, detumescence.Control women's amenorrhea, vicarious menstruation, traumatic injury, rheumatic arthritis, gonorrhea, edema, scrofula, swollen ulcer drug.
Herba equiseti ramosissimi: base is former: be the herb of Equisetaceae plant Herba Clinopodii Polycephali.Chemical analysis: herb contains nicotine, equisetine, Kaempferol-sophoroside-7-glycoside, Kaempferol-sophoroside, sitosterol, stigmasterol.Pharmacological action: the alcohol preserved material that Corii Sus domestica hemostasis SA produces Herba equiseti ramosissimi green portion can cause convulsions and death.Nature and flavor: sweet; Bitter; Flat; Nontoxic; Be slightly cold.Gui Jing: the heart; Liver; Stomach; Urinary bladder channel.Function cures mainly: liver heat removing and eyesight improving; Hemostasis; Inducing diuresis for treating stranguria syndrome; Main anemopyretic cold; Cough; Conjunctival congestion and swelling pain; Nebula; Epistaxis; Hematuria; Discharging fresh blood stool; Stranguria; Jaundice; Leukorrhagia; Fracture.
Cortex Juglandis mandshuricae: base is former: be branch skin or the dried bark of juglandaceae plant Juglans mandshurica.Chemical analysis: bark, leaf and husk contain glycoside and a large amount of tannins etc.Leaf is containing tannin 6.25 ~ 9.35%.Pharmacological action: containing juglone in antitumaous effect Cortex Juglandis mandshuricae, core is chosen and is seized leaf decoct has sugar in acceleration bodies assimilation to rat, or falls hypoglycemic effect.Its method is rat half an hour after oral drugs, with 60% glucose (30ml/kg) gavage, surveys glucose in urine after 2.5-3 hour; Comparatively matched group shows is low for the glucose in urine of administration group.Concoct: clean, run through, stripping and slicing, dry.Nature and flavor: bitter; Pungent; Cold nature.Function cures mainly: heat clearing and damp drying; Eliminating pathogen in the liver improving eyesight.Main damp-heat diarrhea; Normal lower yellow thick; Conjunctival congestion and swelling pain; Hordeolum; Epiphora induced by wind; Bone tuberculosis.
Semen Trigonellae: base is former: be the seed of leguminous plant Semen Trigonellae.Chemical analysis: seed is containing alkaloids such as erythricine, carpaine, choline, trigonellines, and ruscogenin is diosgenin, Yamogenin and a small amount of gitogenin, trace Tigogenin mainly.Still isolate vitexin, vitexin-7-glycoside, orientin or the Arabic glucoside of isorientin, glucose rhamnose two glucoside of flavone, the flavonoid such as Quercetin, luteolin.Pharmacological action: trigonelline be it is generally acknowledged without pharmacological action; But also someone reports that it is in neuromuscular specimen, can reduce neural duration, be then first reduce to increase afterwards to the duration of muscle.Have lactogenic composition in the oil of seed, this composition is not containing iodine, nitrogen, sulfur, and without any gonadotropic Effect, the seed after deoiling contains the stodgy viscose glue of 50%, therefore has some catharsis effect.Seed also has and slight drives the effect of gutstring worm.Nature and flavor: bitter, temperature.Gui Jing: enter kidney, Liver Channel.Function cures mainly: kidney-replenishing, dispelling cold and dampness.Control colic of cold type, abdomen side of body distension, the disturbance of lower legs due to pathogenic cold and dampness, the soreness of waist of suffering from a deficiency of the kidney, sexual impotence.
Rhizoma Polygoni coriacei: base is former: be the rhizome of polygonaceae plant leather leaf knotweed.Nature and flavor: bitter; Cold in nature.Function cures mainly: heat-clearing and toxic substances removing.Main hygropyretic dysentery; Diarrhoea; Carbuncle; Hemorrhoid; Gingival swelling and pain; Erosion of the oral mucosa; Burn; Venom.
Herba Salviae Chinensis: base is former: be the herb of labiate Herba Salviae Chinensis.Chemical analysis: herb is containing sterol, Triterpenoid, aminoacid.Root is containing stachyose.Nature and flavor: " Suzhou this product medical material ": " toil, flat." return through: return liver; Spleen channel.Function cures mainly: control dysphagic, phlegm dyspnea, hepatitis, red and white leukorrhea, carbuncle, scrofula.
Chinese medicine preparation scientific formula provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1,selected materials is all Chinese medicine material, and instant effect, short treating period, cure rate are high, without any side effects;
2,this prescription compatibility is accurate, and curative effect is rapid, has warming for eliminaring cold-damp, removing blood stasis dredging collateral, blood stasis dispersing and fresh blood promoting, short new stock growth, improves the effect of function of joint, have the practicality of wide spectrum;
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1prevent and treat a Chinese medicine preparation for bone tuberculosis, be prepared from by following bulk drugs, be weight portion (65g/ part): Cordyceps 6 parts; Herba Sambuci Chiensis 8 parts; Flos Ginseng 10 parts; Ramulus et Folium Psychotriae Serpentis 7 parts; Herba Limonii Gmelinii 9 parts; Caulis Lonicerae 8 parts; Radix Inulae Pterocaulae 7 parts; Radix seu Caulis Embeliae Parviflorae 10 parts; Radix Cucubali 8 parts; Herba equiseti ramosissimi 11 parts; Cortex Juglandis mandshuricae 9 parts; Semen Trigonellae 8 parts; Rhizoma Polygoni coriacei 9 parts; Herba Salviae Chinensis 8 parts.
A kind of preparation method of preventing and treating the Chinese medicinal tablet of bone tuberculosis is:
(1) Cordyceps and Semen Trigonellae are together placed in pulverizer and clay into power, for subsequent use;
(2) Herba Sambuci Chiensis, Ramulus et Folium Psychotriae Serpentis, Caulis Lonicerae and Herba equiseti ramosissimi are mixed, the vinegar adding 0.18 times of raw material dose is mixed thoroughly, steams to well-done, takes out, mash, and fully, put in parch container, slow fire fried dry, cools, for subsequent use in grinding;
(3) by Flos Ginseng and Herba Salviae Chinensis mixing, the Mel adding 0.12 times amount is mixed thoroughly, and it is degree that slow fire is fried extremely tack-free, takes out dry, smashs into fine powder to pieces, for subsequent use;
(4) by Herba Limonii Gmelinii, Radix Inulae Pterocaulae, Radix seu Caulis Embeliae Parviflorae, Rhizoma Polygoni coriacei, Radix Cucubali and Cortex Juglandis mandshuricae in medicine pot, the clear water adding 6 times of raw material doses soaks 2 hours, and then big fire is heated to boil, turn little fire and decoct 23 minutes slowly, filter, medicinal residues add the clear water of 3.5 times amount again, slow fire boiling 18 minutes, filter, merge twice filtrate, being evaporated to 80 DEG C of relative densities is the thick paste of 1.20-1.23, vacuum drying, get dry extract powder, for subsequent use;
(5) the raw material medicated powder mixing after being processed step (1)-(4), adds magnesium stearate and sucrose fine (raw material medicated powder: magnesium stearate: sucrose fine=4:0.3:0.7), stirs, cross 115 mesh sieves, be processed into tablet, obtain final product.
The instructions of taking of gained tablet of the present invention is: every day three times, each 4-5 sheet, and warm water takes, a course for the treatment of two Mondays.
Model case: king XX, man, 22 years old, student.Patient is to our hospital in JIUYUE in 2011 22 days.Patient's readme: before half a year, after school and classmate have played ball, panesthesia's flank pain, after prostrate rest,, after this all can there is lumbago symptom after each motion, not pay attention at that time in pain relief, after two months, lumbago exacerbation of symptoms, changes every day into bitterly once by pain after original motion, have purchased the treatment of lumbago medicine in Hospital, pain has no alleviation, after to be with by household and to get my institute and check treatment.Check: patient's waist both sides edema, has blood stasis point, stationarity pain as pinprick, and is persistence more, affected part limitation of activity, deep and hesitant pulse.The 2nd, 3,4 lumbar vertebra tuberculosis are diagnosed as through x-ray and CT examination.
Take a kind of Chinese medicinal tablet preventing and treating bone tuberculosis of the present embodiment gained, instructions of taking: every day three times, each 4-5 sheet, warm water takes, a course for the treatment of two Mondays.After taking two courses for the treatment of, the edema of patient's waist both sides disappears, and pain obviously alleviates, and after continuing to take two courses for the treatment of, patient clinical symptom and sign all disappear, and x-ray checks that lumbar vertebra recovery is normal, and patient fully recovers.After drug withdrawal half a year, without recurrence.
embodiment 2prevent and treat a Chinese medicine preparation for bone tuberculosis, be prepared from by following bulk drugs, be weight portion (45g/ part): Cordyceps 12 parts; Herba Sambuci Chiensis 13 parts; Flos Ginseng 14 parts; Ramulus et Folium Psychotriae Serpentis 15 parts; Herba Limonii Gmelinii 14 parts; Caulis Lonicerae 16 parts; Radix Inulae Pterocaulae 12 parts; Radix seu Caulis Embeliae Parviflorae 15 parts; Radix Cucubali 14 parts; Herba equiseti ramosissimi 16 parts; Cortex Juglandis mandshuricae 15 parts; Semen Trigonellae 12 parts; Rhizoma Polygoni coriacei 13 parts; Herba Salviae Chinensis 15 parts.
A kind of preparation method of preventing and treating the Chinese powder medicine of bone tuberculosis is:
(1) Cordyceps is placed in pulverizer and clays into power, for subsequent use;
(2) Herba Limonii Gmelinii, Radix Inulae Pterocaulae, Radix seu Caulis Embeliae Parviflorae, Radix Cucubali and Cortex Juglandis mandshuricae are together placed in parch container, slow fire heats, with stir-fry with spray yellow wine (mass ratio of crude drug and yellow wine is 8:1), when yellow wine is exhausted completely by medical material, slow fire stir-fries to medical material surface in yellow slightly focal spot again, taking-up cools, and smashs into fine powder to pieces, for subsequent use;
(3) mixed by the crude drug except step (1) and (2), fully dry, pulverize into fine powder, the crude drug after processing with step (1) and (2) mixes, and 90 DEG C of dry heat sterilizations 20 minutes, are cooled to room temperature, encapsulates, to obtain final product.
The instructions of taking of gained powder of the present invention is: twice daily, each 15-25g, and warm water is taken after mixing it with water, a course for the treatment of two Mondays.
embodiment 3prevent and treat a Chinese medicine preparation for bone tuberculosis, be prepared from by following bulk drugs, be weight portion (60g/ part): Cordyceps 8 parts; Herba Sambuci Chiensis 9.5 parts; Flos Ginseng 11 parts; Ramulus et Folium Psychotriae Serpentis 9 parts; Herba Limonii Gmelinii 11 parts; Caulis Lonicerae 10 parts; Radix Inulae Pterocaulae 9 parts; Radix seu Caulis Embeliae Parviflorae 11 parts; Radix Cucubali 10 parts; Herba equiseti ramosissimi 12.5 parts; Cortex Juglandis mandshuricae 11 parts; Semen Trigonellae 9 parts; Rhizoma Polygoni coriacei 10 parts; Herba Salviae Chinensis 10 parts.
A kind of preparation method of preventing and treating the Chinese medicine decoction of bone tuberculosis is:
(1) Cordyceps and Flos Ginseng are cleaned respectively, be placed in medicine pot, add the pure water of 3.5 times amount, slow fire heating decoction 8 minutes, when medicinal liquid darkens, stops heating, filters, filtrate and medicinal residues for subsequent use;
(2) Herba Sambuci Chiensis, Caulis Lonicerae, Ramulus et Folium Psychotriae Serpentis, Herba equiseti ramosissimi and Herba Salviae Chinensis are mixed, add mass fraction be 11% Sucus Zingberis and mass fraction be the saline solution of 3.5%, mix thoroughly, stewing 16 minutes, be then placed in hot pot, slow fire dried, and is ground into fine powder, for subsequent use;
(3) be placed in medicine pot by Semen Trigonellae, Cortex Juglandis mandshuricae and Radix Inulae Pterocaulae, it is dark brown that slow fire is heated to medical material, takes out, is ground into fine powder, mixes with step (2) gained fine powder, crosses 160 mesh sieves, obtains mixed powder, for subsequent use;
(4) Herba Limonii Gmelinii, Radix seu Caulis Embeliae Parviflorae, Rhizoma Polygoni coriacei and Radix Cucubali are placed in medicine pot, add pure water and do not have powder 2-4cm, then slow fire decocts 45 minutes slowly, filter, medicinal residues mix with step (1) gained medicinal residues, continue the pure water adding 5 times amount, slow fire boiling 12 minutes, filter, filtrate reduced in volume is to the half of original volume, for subsequent use;
(5) step (1) gained filtrate and step (3) gained mixed powder are joined in above-mentioned filtrate, stir, sterilizing encapsulates, and to obtain final product.
The instructions of taking of gained decoction of the present invention is: twice daily, each 180-200mL, warmly takes, a course for the treatment of two Mondays.
Model case: old XX, female, 31 years old, company personnel.Patient's readme: patient suffers from right tuberculosis of knee joint and had a surplus with 1 year, and at local hospital through Western medicine and massage treatment, symptom alleviates, but have no recovery from illness, after leaving hospital, family numbers of patients asks about traditional Chinese medicine secret recipe everywhere for it, once takes the treatment of various special prescription of Chinese herbal medicine, symptom still has no elimination, just when patient is downhearted time, surprisingly learn that my institute's treatment bone tuberculosis disease effects is good, cure rate is high, then have the attitude of trying in arms, come my institute and check treatment.Check: patient legs is bending can not directly stretch, knee stiffness, at all can be movable, near knee joint, have a lot of pus hole, stream milk yellow pus, patient's ochriasis and becoming thin, diet is few.Be diagnosed as right tuberculosis of knee joint.
Take a kind of Chinese medicine decoction of preventing and treating bone tuberculosis of the present embodiment gained, instructions of taking: twice daily, each 180-200mL, warmly to take, a course for the treatment of two Mondays.After treating two courses for the treatment of, conditions of patients takes a favorable turn, and knee joint can be movable, and lower limb also can be stretched by song, other symptoms obviously alleviate, and the mental status takes a turn for the better, after two courses for the treatment of of continual cure, patient clinical symptom disappears substantially, and joint abscess disappears, and function recovers normal substantially.Patient's self-induction is fully recovered.
embodiment 4prevent and treat a Chinese medicine preparation for bone tuberculosis, be prepared from by following bulk drugs, be weight portion (50g/ part): Cordyceps 10 parts; Herba Sambuci Chiensis 11.5 parts; Flos Ginseng 13 parts; Ramulus et Folium Psychotriae Serpentis 13 parts; Herba Limonii Gmelinii 12 parts; Caulis Lonicerae 14 parts; Radix Inulae Pterocaulae 10 parts; Radix seu Caulis Embeliae Parviflorae 14 parts; Radix Cucubali 12 parts; Herba equiseti ramosissimi 14.5 parts; Cortex Juglandis mandshuricae 13 parts; Semen Trigonellae 11 parts; Rhizoma Polygoni coriacei 12 parts; Herba Salviae Chinensis 13 parts.
A kind of preparation method of preventing and treating the Chinese medicine capsules of bone tuberculosis is:
(1) be placed in by Semen Trigonellae in hot pot, slow fire roasting to surface is buff slightly focal spot, slightly cool, is together placed in pulverizer clays into power with Cordyceps, for subsequent use;
(2) Flos Ginseng, Herba equiseti ramosissimi and Ramulus et Folium Psychotriae Serpentis are placed in hot sand, scald to medical material surface slightly black focal spot, take out, grind to form fine powder, for subsequent use;
(3) be placed in frying pan by the crude drug except step (1) and (2), add clear water and do not have medical material surface, slow fire boiling twice, each each decoction 32 minutes, filter, filtrate reduced in volume to 75 DEG C relative density is the clear paste of 1.18-1.20, for subsequent use;
(4) by step (1) and the mixing of (2) gained medicated powder, cross 95 mesh sieves, join in step (3) gained clear paste, add while stirring mass fraction be 1.1% microcrystalline Cellulose and mass fraction be the corn starch of 3.7%, stir, granulate, drying, incapsulates shell, to obtain final product.
The instructions of taking of gained capsule of the present invention is: every day three times, each 4-5 grain, and warm water is taken, a course for the treatment of two Mondays.
embodiment 5prevent and treat a Chinese medicine preparation for bone tuberculosis, be prepared from by following bulk drugs, be weight portion (55g/ part): Cordyceps 9 parts; Herba Sambuci Chiensis 10.5 parts; Flos Ginseng 12 parts; Ramulus et Folium Psychotriae Serpentis 11 parts; Herba Limonii Gmelinii 11.5 parts; Caulis Lonicerae 12 parts; Radix Inulae Pterocaulae 9.5 parts; Radix seu Caulis Embeliae Parviflorae 12.5 parts; Radix Cucubali 11 parts; Herba equiseti ramosissimi 13.5 parts; Cortex Juglandis mandshuricae 12 parts; Semen Trigonellae 10 parts; Rhizoma Polygoni coriacei 11 parts; Herba Salviae Chinensis 11.5 parts.
A kind of preparation method of preventing and treating the Chinese medicinal tablet of bone tuberculosis is:
(1) Cordyceps and Semen Trigonellae are together placed in pulverizer and clay into power, for subsequent use;
(2) Herba Sambuci Chiensis, Ramulus et Folium Psychotriae Serpentis, Caulis Lonicerae and Herba equiseti ramosissimi are mixed, the vinegar adding 0.26 times of raw material dose is mixed thoroughly, steams to well-done, takes out, mash, and fully, put in parch container, slow fire fried dry, cools, for subsequent use in grinding;
(3) by Flos Ginseng and Herba Salviae Chinensis mixing, the Mel adding 0.15 times amount is mixed thoroughly, and it is degree that slow fire is fried extremely tack-free, takes out dry, smashs into fine powder to pieces, for subsequent use;
(4) by Herba Limonii Gmelinii, Radix Inulae Pterocaulae, Radix seu Caulis Embeliae Parviflorae, Rhizoma Polygoni coriacei, Radix Cucubali and Cortex Juglandis mandshuricae in medicine pot, the clear water adding 7.5 times of raw material doses soaks 3 hours, and then big fire is heated to boil, turn little fire and decoct 34 minutes slowly, filter, medicinal residues add the clear water of 5 times amount again, slow fire boiling 18 minutes, filter, merge twice filtrate, being evaporated to 80 DEG C of relative densities is the thick paste of 1.20-1.23, vacuum drying, get dry extract powder, for subsequent use;
(5) the raw material medicated powder mixing after being processed step (1)-(4), adds magnesium stearate and sucrose fine (raw material medicated powder: magnesium stearate: sucrose fine=4:0.3:0.7), stirs, cross 130 mesh sieves, be processed into tablet, obtain final product.
The instructions of taking of gained tablet of the present invention is: every day three times, each 4-5 sheet, and warm water takes, a course for the treatment of two Mondays.
test example: for showing a kind of therapeutic effect preventing and treating the Chinese medicine preparation (embodiment 5) of bone tuberculosis of the present invention, carried out clinical observation to 326 routine cases, existing report is as follows:
1. data and method
1.1 physical data:
In JIUYUE, 2010 in July ,-2013, screen 326 routine bone tuberculosis patients in four hospitals, male patient 176 example, female patient 150 example; Age is in 14-65 year, 40.5 ± 2.5 years old mean age, the course of disease was at 2 months-16 months, and wherein patient's totally 123 examples are sent out at vertebra position, and hip region sends out patient's totally 91 examples, rib cage areas sends out patient's totally 68 examples, patient's totally 44 examples are sent out at other positions, all patients be divided at random experimental group 210 example and matched group 116 routine, two groups of patients in sex, age, the course of disease through statistical procedures, no statistical significance (P > 0.05), has comparability.
1.2 diagnostic criteria
(1) x-ray screening checks, has obvious bone destruction, meets bone tuberculosis diagnosis; (2) lesions position local diffusivity swells and ache, aches, and rear pus of bursting is clear or held bean curd slag specimen thing under the arm; (3) in conjunction with positive bacterial culture.
1.3 Therapeutic Method
Experimental group takes gained gained medicine of the present invention, instructions of taking: every day three times, each 4-5 sheet, and warm water takes, a course for the treatment of two Mondays.Matched group takes other medicines (as taking the conventional medicines such as isoniazid, rifampicin, pyrazinamide).Observe 4 courses for the treatment of of treatment altogether.
1.4 criterion of therapeutical effect
With reference to the disease of tcm Standardization of diagnosis and curative effect relevant bone tuberculosis evaluation curative effect that State Administration of Traditional Chinese Medicine promulgates.Cure: clinical symptoms disappears completely, and pain and sense of discomfort disappear completely, X-ray examination recovers normal; Effective: body temperature is normal, pain component disappears, and tuberculosis symptom obviously alleviates, and X-ray examination obviously improves; Invalid: symptom is without improvement, and X-ray examination is without improvement.Effective percentage=(curing number of cases+effective number of cases)/total inspection case load × 100%.
1.5 therapeutic outcome contrasts
Clinical efficacy comparison after two groups of patient treatments, as shown in table 1.
Clinical efficacy comparison after table 1 liang group patient treatment
Therapeutic outcome: as shown in Table 1, experimental group effective percentage is 98.1%, and matched group effective percentage is 80.2%, and known experimental group therapeutic effect is obviously better than matched group, and difference has statistical significance (P < 0.05).
Medicine of the present invention adopts the formula of " heat-clearing and toxic substances removing, hard masses softening and resolving, yin nourishing tonify deficiency, strengthening vital QI to eliminate pathogenic factors ".Fang Zhong, Cordyceps has tonifying deficiency, the function of beneficial vital essence; Herba Sambuci Chiensis have analgesia, promoting blood circulation to remove blood stasis, increase phosphorus absorption, promote the effect that callus is ossified; Ramulus et Folium Psychotriae Serpentis wind-damp dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, reducing swelling and alleviating pain; Radix Inulae Pterocaulae tonify deficiency, heat clearing away; Semen Trigonellae kidney-replenishing, dispelling cold and dampness.Full side gathers the merit of heat-clearing and toxic substances removing, removing blood stasis dredging collateral, blood stasis dispersing and fresh blood promoting, hard masses softening and resolving altogether.It is 98.1% that patient takes experimental group effective percentage after 4 courses for the treatment of, and matched group is only 80.2%, and experimental group therapeutic effect is obviously better than matched group.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. prevent and treat a Chinese medicine preparation for bone tuberculosis, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Cordyceps 6-12; Herba Sambuci Chiensis 8-13; Flos Ginseng 10-14; Ramulus et Folium Psychotriae Serpentis 7-15; Herba Limonii Gmelinii 9-14; Caulis Lonicerae 8-16; Radix Inulae Pterocaulae 7-12; Radix seu Caulis Embeliae Parviflorae 10-15; Radix Cucubali 8-14; Herba equiseti ramosissimi 11-16; Cortex Juglandis mandshuricae 9-15; Semen Trigonellae 8-12; Rhizoma Polygoni coriacei 9-13; Herba Salviae Chinensis 8-15.
2. a kind of Chinese medicine preparation preventing and treating bone tuberculosis as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Cordyceps 8-10; Herba Sambuci Chiensis 9.5-11.5; Flos Ginseng 11-13; Ramulus et Folium Psychotriae Serpentis 9-13; Herba Limonii Gmelinii 11-12; Caulis Lonicerae 10-14; Radix Inulae Pterocaulae 9-10; Radix seu Caulis Embeliae Parviflorae 11-14; Radix Cucubali 10-12; Herba equiseti ramosissimi 12.5-14.5; Cortex Juglandis mandshuricae 11-13; Semen Trigonellae 9-11; Rhizoma Polygoni coriacei 10-12; Herba Salviae Chinensis 10-13.
3. a kind of Chinese medicine preparation preventing and treating bone tuberculosis as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Cordyceps 9; Herba Sambuci Chiensis 10.5; Flos Ginseng 12; Ramulus et Folium Psychotriae Serpentis 11; Herba Limonii Gmelinii 11.5; Caulis Lonicerae 12; Radix Inulae Pterocaulae 9.5; Radix seu Caulis Embeliae Parviflorae 12.5; Radix Cucubali 11; Herba equiseti ramosissimi 13.5; Cortex Juglandis mandshuricae 12; Semen Trigonellae 10; Rhizoma Polygoni coriacei 11; Herba Salviae Chinensis 11.5.
4. a kind of Chinese medicine preparation preventing and treating bone tuberculosis as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) Cordyceps and Semen Trigonellae are together placed in pulverizer and clay into power, for subsequent use;
(2) Herba Sambuci Chiensis, Ramulus et Folium Psychotriae Serpentis, Caulis Lonicerae and Herba equiseti ramosissimi are mixed, add vinegar and mix thoroughly, steam to well-done, take out, mash, fully, put in parch container, slow fire fried dry, cools, for subsequent use in grinding;
(3) by Flos Ginseng and Herba Salviae Chinensis mixing, the Mel adding 0.12-0.18 times amount is mixed thoroughly (Mel preferably adding 0.15 times amount is mixed thoroughly), and it is degree that slow fire is fried extremely tack-free, takes out dry, smashs into fine powder to pieces, for subsequent use;
(4) by Herba Limonii Gmelinii, Radix Inulae Pterocaulae, Radix seu Caulis Embeliae Parviflorae, Rhizoma Polygoni coriacei, Radix Cucubali and Cortex Juglandis mandshuricae in medicine pot, add clear water and soak 2-4 hour (preferably add clear water and soak 3 hours), then big fire is heated to boil, turn little fire to decoct slowly 23-45 minute (preferably turn little fire and decoct 34 minutes slowly), filter, medicinal residues add the clear water (preferred medicinal residues add the clear water of 5 times amount again) of 3.5-6.5 times amount again, slow fire boiling 18 minutes, filter, merge twice filtrate, being evaporated to 80 DEG C of relative densities is the thick paste of 1.20-1.23, vacuum drying, get dry extract powder, for subsequent use;
(5) the raw material medicated powder mixing after step (1)-(4) being processed, add magnesium stearate and sucrose fine (raw material medicated powder: magnesium stearate: sucrose fine=4:0.3:0.7), stir, cross 115-145 mesh sieve (preferred mistake 130 mesh sieve), be processed into tablet, obtain final product.
5. a kind of preparation method of preventing and treating the Chinese medicinal tablet of bone tuberculosis according to claim 4, it is characterized in that, in step (2), the amount of vinegar is the 0.18-0.34 of raw material dose doubly (amount of preferred vinegar is 0.22-0.30 times of raw material dose, and the amount of the vinegar be more preferably is 0.26 times of raw material dose).
6. a kind of preparation method of preventing and treating the Chinese medicinal tablet of bone tuberculosis according to claim 4, it is characterized in that, in step (4), the amount of clear water is the 6-9 of raw material dose doubly (amount of preferred clear water is 7-8 times of raw material dose, and the amount of the clear water be more preferably is 7.5 times of raw material dose).
7. a kind of Chinese medicine preparation preventing and treating bone tuberculosis as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable powder, preparation method is as follows:
(1) Cordyceps is placed in pulverizer and clays into power, for subsequent use;
(2) be together placed in parch container by Herba Limonii Gmelinii, Radix Inulae Pterocaulae, Radix seu Caulis Embeliae Parviflorae, Radix Cucubali and Cortex Juglandis mandshuricae, slow fire heats, with stir-fry with spray yellow wine, when yellow wine is exhausted completely by medical material, then slow fire stir-fries to medical material surface in yellow slightly focal spot, and taking-up cools, smash into fine powder to pieces, for subsequent use;
(3) crude drug except step (1) and (2) is mixed, fully dry, pulverize into fine powder, crude drug after processing with step (1) and (2) mixes, and 78-102 DEG C of dry heat sterilization 20 minutes (preferably 90 DEG C dry heat sterilization 20 minutes), is cooled to room temperature, encapsulation, to obtain final product.
8. a kind of preparation method of preventing and treating the Chinese powder medicine of bone tuberculosis according to claim 7, it is characterized in that, the mass ratio of step (2) Raw medicine and yellow wine is the mass ratio of the preferred crude drug of 8:0.8-1.2(and yellow wine is 8:0.9-1.1, and the crude drug be more preferably and the mass ratio of yellow wine are 8:1).
9. a kind of Chinese medicine preparation preventing and treating bone tuberculosis as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Cordyceps and Flos Ginseng are cleaned respectively, be placed in medicine pot, add the pure water (preferably adding the pure water of 3.5 times amount) of 2.5-4.5 times amount, slow fire heating decocts 6-10 minute (preferred slow fire heating decoction 8 minutes), when medicinal liquid darkens, stop heating, filter, filtrate and medicinal residues for subsequent use;
(2) by Herba Sambuci Chiensis, Caulis Lonicerae, Ramulus et Folium Psychotriae Serpentis, Herba equiseti ramosissimi and Herba Salviae Chinensis mix, add mass fraction be 11% Sucus Zingberis and mass fraction be the saline solution of 3.5%, mix thoroughly, stewing 12-20 minute (preferably stewing 16 minutes), be then placed in hot pot, slow fire dries, be ground into fine powder, for subsequent use;
(3) be placed in medicine pot by Semen Trigonellae, Cortex Juglandis mandshuricae and Radix Inulae Pterocaulae, it is dark brown that slow fire is heated to medical material, takes out, is ground into fine powder, mixes with step (2) gained fine powder, crosses 140-180 mesh sieve (preferred mistake 160 mesh sieve), obtains mixed powder, for subsequent use;
(4) Herba Limonii Gmelinii, Radix seu Caulis Embeliae Parviflorae, Rhizoma Polygoni coriacei and Radix Cucubali are placed in medicine pot, add pure water and do not have powder 2-4cm, then slow fire is decocted 35-55 minute (preferably then slow fire decocts 45 minutes slowly) slowly, filter, medicinal residues mix with step (1) gained medicinal residues, continue the pure water (preferably continuing to add the pure water of 5 times amount) adding 3.5-6.5 times amount, slow fire boiling 8-16 minute (preferred slow fire boiling 12 minutes), filter, filtrate reduced in volume is to the half of original volume, for subsequent use;
(5) step (1) gained filtrate and step (3) gained mixed powder are joined in above-mentioned filtrate, stir, sterilizing encapsulates, and to obtain final product.
10. a kind of Chinese medicine preparation preventing and treating bone tuberculosis as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:
(1) be placed in by Semen Trigonellae in hot pot, slow fire roasting to surface is buff slightly focal spot, slightly cool, is together placed in pulverizer clays into power with Cordyceps, for subsequent use;
(2) Flos Ginseng, Herba equiseti ramosissimi and Ramulus et Folium Psychotriae Serpentis are placed in hot sand, scald to medical material surface slightly black focal spot, take out, grind to form fine powder, for subsequent use;
(3) crude drug except step (1) and (2) is placed in frying pan, adds clear water and do not have medical material surface, slow fire boiling twice, each respectively decoction 24-40 minute (preferably each each decoction 32 minutes), filter, filtrate reduced in volume to 75 DEG C relative density is the clear paste of 1.18-1.20, for subsequent use;
(4) by step (1) and the mixing of (2) gained medicated powder, cross 75-115 mesh sieve (preferred mistake 95 mesh sieve), join in step (3) gained clear paste, add while stirring mass fraction be 1.1% microcrystalline Cellulose and mass fraction be the corn starch of 3.7%, stir, granulate, dry, incapsulate shell, to obtain final product.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810761A (en) * | 2010-04-29 | 2010-08-25 | 李三猛 | Medicament for treating tuberculosis |
| CN104887805A (en) * | 2015-07-06 | 2015-09-09 | 苗怡文 | Traditional Chinese medicine preparation for treating bone tuberculosis and preparation method therefor |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810761A (en) * | 2010-04-29 | 2010-08-25 | 李三猛 | Medicament for treating tuberculosis |
| CN104887805A (en) * | 2015-07-06 | 2015-09-09 | 苗怡文 | Traditional Chinese medicine preparation for treating bone tuberculosis and preparation method therefor |
Non-Patent Citations (1)
| Title |
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| 刘惠民: "中药治疗脊骨结核一例", 《中国防痨杂志》 * |
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