CN105168913A - Medicine composition for treating cholecystitis and preparation method thereof - Google Patents
Medicine composition for treating cholecystitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for treating cholecystitis and a preparation method thereof. The medicine composition is prepared by taking tuber salep, vulture excrement, berberis thunbergii fruits, diversifolious hemiphragma herb glucoside B, cylindrin and amentotaxus biflavone as crude drugs, and proportioning. The medicine composition can be prepared into various preparations according to a conventional preparation process and has a remarkable effect on treating cholecystitis.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the treatment of cholecystitis and preparation method thereof.
Background technology
Cholecystitis is the gallbladder inflammatory lesion that bacterial infection or chemical irritation (bile component change) cause, and is the commonly encountered diseases of gallbladder.In abdominal surgery, its sickness rate is only second to appendicitis, and primary disease is more common in the middle age of 35 ~ 55 years old, and the women comparatively male that falls ill for many, is more common in obesity and the women of multiple pregnancies especially.Relax clinical performance according to the urgency of morbidity and can be divided into acute and chronic two classes, all belong to biliary infection category.The symptom of acute cholecystitis, mainly contains upper right abdomen pain, Nausea and vomiting and heating etc.Acute cholecystitis can cause right Upper abdominal pain, at the beginning pain and biliary colic closely similar, but its time continued of the stomachache that causes of acute cholecystitis is often longer, breathes and change position usually to make pain increase the weight of, therefore patient likes reposing to the right more, to alleviate abdomen pain.Some patient has nausea and vomiting, but vomiting is general inviolent.Most patient is also with heating, and body temperature is usually between 38.0 DEG C ~ 38.5 DEG C, and Gao Re is actually rare with shiver with cold.A few patients also has the white of the eye and skin slightly to turn to be yellow.When doctor checks the abdominal part of patient, can find that right upper quadrant of the abdomen has tenderness, and have tension of abdominal muscle, the gallbladder of enlargement can also be touched greatly in the patient of 1/3.The blood of chemical examination patient, can find the numeration of leukocyte in most human blood and neutrophilia.Ultrasound diagnosis can find gollbladder dilation, cyst wall thickens, and visible calculus gets lodged in the cervical region of gallbladder.According to above symptom, physical examination and various auxiliary examination, doctor generally can make the diagnosis of acute cholecystitis in time.
Western medical treatment divides expectant treatment and operative treatment.Expectant treatment is to lie up, and strengthen nutrition, the intravenous drip of medicine many employings antibiotics, indometacin is oral, though achieve the good effect of short-term, easily repeatedly; Operative treatment is excision cholecystitis, but the mortality rate 0.5-3% of operative therapy, jaundice case mortality is 10-15%, and gerontal case mortality rate is up to 13.5-16%, and operation intercurrent disease is about 15%.Therefore operative therapy as treatment cholecystitis basic therapy be unsafty.The Chinese medicine of current treatment cholecystitis mainly contains, Decoction of Gentiana for Purging the Liver-fire, depressed liver-energy dispersing and function of gallbladder promoting soup, soothing liver-QI Stomach-Regulating Decoction, stomach invigorating circulation of qi promoting soup, XIAOYAN LIDAN PIAN, depressed liver-energy dispersing and function of gallbladder promoting cream, clearing gallbladder circulation of qi promoting soup, clearing away heat-damp and promoting diuresis soup, clearing gallbladder pathogenic fire purging soup, bupleurum root decoction, tarragon soup adjust that five a kind of reed mentioned in ancient books are loose, Herba Artemisiae Scopariae and CHENGQI TANG, Daxianxiong Tang etc., although these medicines have certain curative effect, but still can not be satisfactory.
Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), this product is the dry tuber of orchid helmet Herba Orchidis Latifoliae OrchismorioL., Bears Herba Orchidis Latifoliae OrchismasculaL., variegated leaf Herba Orchidis Latifoliae OrchismaculateL., the blue OrchischloranthaGust. of LVHUA tongue lip etc.Xia Qiu excavates, removing impurity, and put a moment in boiling water, taking-up is dried.Character, secondary is damp and hot.There is tonifying YANG spermatogenesis, the effect of the hemopoietic that nourishes heart.For the weak premature ejaculation of sun, refreshing tired insufficiency of blood, oligospermia is infertile, and human body is twitched, and paralysis is dull-witted, alopecia, difference of sleeping.
Radix Berberidis Amurensis fruit: this product is the dry mature fruit of Berberidaceae plant Berberis nummularia Bge. BerberisnummulariaBge..Its property put down, have stomach invigorating and in, promoting the production of body fluid to quench thirst, effect of heat-clearing and toxic substances removing.For dyspepsia, under dysentery is rushed down, thirsty, aphtha, pharyngitis.
Vulture excrement, this product is the excrement of Falconiformes Accipitridae animal Aegypius monachus (Linnaeus) AegypiusmonachusLinnaeus or Hu Aegypius monachus (Linnaeus) GypaetusbarbatusLinnaeus.Main product is in western Xinjiang, West Part of Gansu and the northwestward, Qinghai and Tibet.The whole year all can gather.Warm in nature, acrid in the mouth.Have stomach warming and in, helping digestion loose long-pending, effect of ripe pus.Do not change for cold syndrome of the stomach, food, stomach painful abdominal mass tumor.External curing furuncle carbuncle.
Herba hemipharagmatis heterophylli glycosides B(HemiphrosideB): CAS 165338-28-3, molecular formula C
31h
38o
17, molecular weight 682.6.
Cylindrin (cylindrin): CAS 17904-55-1, molecular formula C
31h
52o, molecular weight 440.74398.
Amentoflavone (amentoflavone) No. CAS: 1617-53-4, molecular formula C
30h
18o
10, molecular weight 538.46, antifungal (Aspergillus fumigatus, Botrytis cinerea and powder green trichoderma bacterium); Nucleoside-diphosphatase inhibitor;
Cylindrin (cylindrin) amentoflavone (amentoflavone)
Herba hemipharagmatis heterophylli glycosides B(HemiphrosideB).
Summary of the invention
The object of the invention is the deficiency overcoming background technology, pharmaceutical composition of a kind of effective treatment cholecystitis and preparation method thereof is provided.
The present invention adopts following technical scheme to realize:
Composition and the weight portion of making the crude drug of the pharmaceutical composition of this treatment cholecystitis are:
Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 180-200 weight portion vulture excrement 165-175 weight portion Radix Berberidis Amurensis fruit 140-160 weight portion Herba hemipharagmatis heterophylli glycosides B3-4 weight portion Cylindrin 1-2 weight portion amentoflavone 0.3-0.9 weight portion.
Preferably be used for the treatment of the pharmaceutical composition of cholecystitis, be made up of the crude drug of following weight portion:
Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 190 weight portion vulture excrement 170 weight portion Radix Berberidis Amurensis fruit 150 weight portion Herba hemipharagmatis heterophylli glycosides B3.5 weight portion Cylindrin 1.5 weight portion amentoflavone 0.6 weight portions.
Treat a pharmaceutical composition for cholecystitis, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet, capsule, drop pill.
Treat a pharmaceutical composition for cholecystitis, it is characterized in that the treatment cholecystitis medicine that pharmaceutical composition and chemical drugs or Chinese medicine form.
Treat a preparation method for the pharmaceutical composition of cholecystitis, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 180-200 weight portion vulture excrement 165-175 weight portion Radix Berberidis Amurensis fruit 140-160 weight portion Herba hemipharagmatis heterophylli glycosides B3-4 weight portion Cylindrin 1-2 weight portion amentoflavone 0.3-0.9 weight portion;
Preparation method:
(1) Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), vulture excrement is got by crude drug proportioning, mixing, micronizing to 90 micron, with weight percent concentration 85% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load be Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), 15 times of vulture excrement medical material gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) Radix Berberidis Amurensis fruit is got by crude drug proportioning, micronizing to 70 micron, and obtain medicinal residues A with step (1) and mix, be solvent with weight percent concentration 15% ethanol, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 40% again, collect weight percent concentration 40% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get Herba hemipharagmatis heterophylli glycosides B, Cylindrin, amentoflavone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
Preferably treat a preparation method for the pharmaceutical composition of cholecystitis, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 190 weight portion vulture excrement 170 weight portion Radix Berberidis Amurensis fruit 150 weight portion Herba hemipharagmatis heterophylli glycosides B3.5 weight portion Cylindrin 1.5 weight portion amentoflavone 0.6 weight portions;
Preparation method:
(1) Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), vulture excrement is got by crude drug proportioning, mixing, micronizing to 90 micron, with weight percent concentration 85% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load be Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), 15 times of vulture excrement medical material gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) Radix Berberidis Amurensis fruit is got by crude drug proportioning, micronizing to 70 micron, and obtain medicinal residues A with step (1) and mix, be solvent with weight percent concentration 15% ethanol, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 40% again, collect weight percent concentration 40% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get Herba hemipharagmatis heterophylli glycosides B, Cylindrin, amentoflavone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
Treat a preparation method for the pharmaceutical composition of cholecystitis, it is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet, capsule, drop pill.
Treat a preparation method for the pharmaceutical composition of cholecystitis, it is characterized in that the treatment cholecystitis medicine that pharmaceutical composition and chemical drugs or Chinese medicine form.
Pharmaceutical composition is evident in efficacy in treatment cholecystitis, and total effective rate is 100%.
Detailed description of the invention
Embodiment 1: pharmaceutical composition for the treatment of cholecystitis and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of cholecystitis are:
Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 190 weight portion vulture excrement 170 weight portion Radix Berberidis Amurensis fruit 150 weight portion Herba hemipharagmatis heterophylli glycosides B3.5 weight portion Cylindrin 1.5 weight portion amentoflavone 0.6 weight portions;
Preparation method:
(1) Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), vulture excrement is got by crude drug proportioning, mixing, micronizing to 90 micron, with weight percent concentration 85% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load be Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), 15 times of vulture excrement medical material gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) Radix Berberidis Amurensis fruit is got by crude drug proportioning, micronizing to 70 micron, and obtain medicinal residues A with step (1) and mix, be solvent with weight percent concentration 15% ethanol, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 40% again, collect weight percent concentration 40% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get Herba hemipharagmatis heterophylli glycosides B, Cylindrin, amentoflavone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
Embodiment 2: pharmaceutical composition for the treatment of cholecystitis and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of cholecystitis are:
Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 180 weight portion vulture excrement 175 weight portion Radix Berberidis Amurensis fruit 140 weight portion Herba hemipharagmatis heterophylli glycosides B4 weight portion Cylindrin 1 weight portion amentoflavone 0.9 weight portions;
Preparation method:
(1) Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), vulture excrement is got by crude drug proportioning, mixing, micronizing to 90 micron, with weight percent concentration 85% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load be Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), 15 times of vulture excrement medical material gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) Radix Berberidis Amurensis fruit is got by crude drug proportioning, micronizing to 70 micron, and obtain medicinal residues A with step (1) and mix, be solvent with weight percent concentration 15% ethanol, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 40% again, collect weight percent concentration 40% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get Herba hemipharagmatis heterophylli glycosides B, Cylindrin, amentoflavone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
Embodiment 3: pharmaceutical composition for the treatment of cholecystitis and preparation method thereof
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of cholecystitis are:
Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 200 weight portion vulture excrement 165 weight portion Radix Berberidis Amurensis fruit 160 weight portion Herba hemipharagmatis heterophylli glycosides B3 weight portion Cylindrin 2 weight portion amentoflavone 0.3 weight portions;
Preparation method:
(1) Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), vulture excrement is got by crude drug proportioning, mixing, micronizing to 90 micron, with weight percent concentration 85% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load be Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), 15 times of vulture excrement medical material gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) Radix Berberidis Amurensis fruit is got by crude drug proportioning, micronizing to 70 micron, and obtain medicinal residues A with step (1) and mix, be solvent with weight percent concentration 15% ethanol, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 40% again, collect weight percent concentration 40% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get Herba hemipharagmatis heterophylli glycosides B, Cylindrin, amentoflavone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
Embodiment 4: the preparation of tablet
Example 1 compositions 125g, adds starch 55g, mixing, granulates, dry, adds microcrystalline Cellulose 25g, magnesium stearate 1.0g, and mixing, is pressed into 1000, obtains present composition tablet.
Embodiment 5: the preparation of capsule
Example 2 compositions 125g, adds starch 55g, mixing, granulates, and dry, granulate, adds appropriate magnesium stearate, and mixing, obtains present composition capsule by encapsulated 1000.
Embodiment 6: the preparation of drop pill
Taking polyethylene glycol 6000 200g water-bath (80 DEG C) heating boils molten, add embodiment 3 compositions 25g, stirring, is coolant with liquid paraffin, puts in glass tubing (4*80cm), chilling temperature is 6 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 2.5cm apart from liquid level, drips speed with per minute 50 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain present composition drop pill.
Embodiment 7: the pharmaceutical composition for the treatment of cholecystitis
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of cholecystitis are:
Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 100 weight portion Herba hemipharagmatis heterophylli glycosides B1.5 weight portion Cylindrin 0.4 weight portion amentoflavone 1 weight portion.
Embodiment 8: the pharmaceutical composition for the treatment of cholecystitis
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of cholecystitis are:
Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 200 weight portion Herba hemipharagmatis heterophylli glycosides B4 weight portion Cylindrin 1 weight portion amentoflavone 0.9 weight portion.
Embodiment 9: the pharmaceutical composition for the treatment of cholecystitis
Composition and the weight portion of the crude drug of the pharmaceutical composition for the treatment of cholecystitis are:
Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 150 weight portion Herba hemipharagmatis heterophylli glycosides B3 weight portion Cylindrin 1.2 weight portion amentoflavone 5 weight portion.
experimental example 1: treatment acute cholecystitis experimental study
1. case inclusive criteria
Though traditional medicine is without the name of disease of cholecystitis, but the disease of its disease is early recognized with diagnosis and is recorded, the clinical characters of primary disease is upper right abdomen and side of body costalgia or epigastrium pit of the stomach place pain, heating or alternate attack of chill and fever or often have epigastric distension and distress with jaundice, feel sick, the symptom such as heating installation, distention and fullness in the abdomen.Acute and chronic cholecystitis, cholangitis is contained in the disease such as hypochondriac pain, gastropathy, irritability pain, incoordination between the liver and stomach, jaundice, blocked-up chest Shaoyang disease, gallbladder-distention, distension related to the liver of therefore traditional medicine.
Diagnostic criteria: upper right abdomen break-through pain, and take on back radiation to the right, with heating, Nausea and vomiting, health check-up upper right abdominal pressure pain and flesh are defended, and murphy sign is positive, and numeration of leukocyte increases, and B ultrasonic shows gallbladder wall edema, can be diagnosed as acute cholecystitis.
Selector close standard of stating case 60 example, wherein male 30 example, women 30 example, 35 years old mean age.
2. therapeutic scheme
Treatment group gives embodiment 1 pharmaceutical composition (lot number 20120625), every day 3 times, each 2g, and it is a course for the treatment of that mild is taken medicine 5-7 days, 2 courses for the treatment of of patient with severe symptoms.
3. the standard of curative effect evaluation
recovery from illness:the symptoms such as right Upper abdominal pain, nausea and vomiting disappear completely; Upper right of having a medical check-up abdomen, without tenderness, does not touch gallbladder-murphy sign negative; Ultrasound diagnosis gallbladder is normal, shrinks good.
take a turn for the better:right Upper abdominal pain obviously alleviates, there occasionally have to be nauseating, but without vomiting, bitter taste, the light tenderness of upper right of having a medical check-up abdomen, can touch great gallbladder sometimes, and Boas' sign is negative; Numeration of leukocyte and neutrophilic granulocyte normal; Ultrasound diagnosis gallbladder is bigger.
invalid:general Symptoms is without improvement.
4. therapeutic outcome
Transference cure in mild 7 days, transference cure in general 14 days of patient with severe symptoms, blood routine examination is normal.B ultrasonic shows that gallbladder wall edema disappears.Through statistics effective percentage 100%, cure 26 examples, cure rate 86.7%.
Model case:
(1) Zhu's ××, female, 38 years old, autumn in 2012 was ill, time medical, upper right abdomen break-through pain, and take on back radiation to the right, sharp ache, defecates rare.Once quiet metronidazole, oral indometacin 3 days, within 1 day, through taking pharmaceutical composition of the present invention, every day 3 times, each 2g, serve on 7 days again repeatedly in drug withdrawal, and pain relief also progressively disappears, and does not recur so far.
(2) Lee's ××, man, 45 years old, main suit time medical: recurrent exerbation upper right abdomen break-through pain, companion's Nausea and vomiting.Have a medical check-up: upper right abdominal pressure pain and flesh are defended, and murphy sign is positive, ultrasound diagnosis gallbladder wall edema, and through taking pharmaceutical composition of the present invention, every day 3 times, each 2g, serve on 10 days, and pain disappears, ultrasound diagnosis: gallbladder wall edema disappears, and does not recur so far.
Claims (8)
1. treat a pharmaceutical composition for cholecystitis, it is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 180-200 weight portion vulture excrement 165-175 weight portion Radix Berberidis Amurensis fruit 140-160 weight portion Herba hemipharagmatis heterophylli glycosides B3-4 weight portion Cylindrin 1-2 weight portion amentoflavone 0.3-0.9 weight portion.
2. a kind of pharmaceutical composition for the treatment of cholecystitis according to claim 1, is characterized in that the composition of the crude drug making this pharmaceutical composition and weight portion are:
Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 190 weight portion vulture excrement 170 weight portion Radix Berberidis Amurensis fruit 150 weight portion Herba hemipharagmatis heterophylli glycosides B3.5 weight portion Cylindrin 1.5 weight portion amentoflavone 0.6 weight portions.
3. a kind of pharmaceutical composition for the treatment of cholecystitis according to claim 1, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet, capsule, drop pill.
4. a kind of pharmaceutical composition for the treatment of cholecystitis according to claim 1, is characterized in that the treatment cholecystitis medicine that pharmaceutical composition and chemical drugs or Chinese medicine form.
5. treat a preparation method for the pharmaceutical composition of cholecystitis, it is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 180-200 weight portion vulture excrement 165-175 weight portion Radix Berberidis Amurensis fruit 140-160 weight portion Herba hemipharagmatis heterophylli glycosides B3-4 weight portion Cylindrin 1-2 weight portion amentoflavone 0.3-0.9 weight portion;
Preparation method:
(1) Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), vulture excrement is got by crude drug proportioning, mixing, micronizing to 90 micron, with weight percent concentration 85% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load be Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), 15 times of vulture excrement medical material gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) Radix Berberidis Amurensis fruit is got by crude drug proportioning, micronizing to 70 micron, and obtain medicinal residues A with step (1) and mix, be solvent with weight percent concentration 15% ethanol, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 40% again, collect weight percent concentration 40% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get Herba hemipharagmatis heterophylli glycosides B, Cylindrin, amentoflavone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
6. a kind of preparation method for the treatment of the pharmaceutical composition of cholecystitis according to claim 5, is characterized in that preparing as follows:
The composition of crude drug and weight portion are: Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae) 190 weight portion vulture excrement 170 weight portion Radix Berberidis Amurensis fruit 150 weight portion Herba hemipharagmatis heterophylli glycosides B3.5 weight portion Cylindrin 1.5 weight portion amentoflavone 0.6 weight portions;
Preparation method:
(1) Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), vulture excrement is got by crude drug proportioning, mixing, micronizing to 90 micron, with weight percent concentration 85% ethanol as solvent, 50 DEG C of warm macerating extract, and extraction time is 3 times, each extraction time is 2 hours, each solvent load be Central Asia Pseudobulbus Bletillae (Rhizoma Bletillae), 15 times of vulture excrement medical material gross weight, filter, obtain medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentrated, dry, obtain extract A;
(2) Radix Berberidis Amurensis fruit is got by crude drug proportioning, micronizing to 70 micron, and obtain medicinal residues A with step (1) and mix, be solvent with weight percent concentration 15% ethanol, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, be concentrated into relative density 1.14, filter, medicinal liquid is by LS300 macroporous adsorptive resins, first wash with water, use the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 40% again, collect weight percent concentration 40% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) get Herba hemipharagmatis heterophylli glycosides B, Cylindrin, amentoflavone by crude drug proportioning, mixing, adds extract A, extract B successively, and mixing, obtains pharmaceutical composition.
7. a kind of preparation method for the treatment of the pharmaceutical composition of cholecystitis according to claim 5, is characterized in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to be prepared into tablet, capsule, drop pill.
8. a kind of preparation method for the treatment of the pharmaceutical composition of cholecystitis according to claim 5, is characterized in that the treatment cholecystitis medicine that pharmaceutical composition and chemical drugs or Chinese medicine form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510568437.XA CN105168913A (en) | 2015-09-09 | 2015-09-09 | Medicine composition for treating cholecystitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510568437.XA CN105168913A (en) | 2015-09-09 | 2015-09-09 | Medicine composition for treating cholecystitis and preparation method thereof |
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| CN105168913A true CN105168913A (en) | 2015-12-23 |
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| CN201510568437.XA Withdrawn CN105168913A (en) | 2015-09-09 | 2015-09-09 | Medicine composition for treating cholecystitis and preparation method thereof |
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| Country | Link |
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2015
- 2015-09-09 CN CN201510568437.XA patent/CN105168913A/en not_active Withdrawn
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Application publication date: 20151223 |
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| WW01 | Invention patent application withdrawn after publication |