CN105168417A - Medicine preparation for treating prolapse of lumbar intervertebral disc - Google Patents
Medicine preparation for treating prolapse of lumbar intervertebral disc Download PDFInfo
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- CN105168417A CN105168417A CN201510654464.9A CN201510654464A CN105168417A CN 105168417 A CN105168417 A CN 105168417A CN 201510654464 A CN201510654464 A CN 201510654464A CN 105168417 A CN105168417 A CN 105168417A
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations and particularly provides a medicine preparation for treating prolapse of the lumbar intervertebral disc. The medicine preparation is prepared from 28 parts of radix thalictri simplicis, 20 parts of dionaea muscipula, 25 parts of caesalpinia cucullata, 18 parts of lespedeza cuneata, 26 parts of ridix fici hirtae, 18 parts of angelica sinensis, 20 parts of manis pentadactyla, 25 parts of the root of common peony, 25 parts of centipeda minima, 20 parts of myrrh, 20 parts of ophidia, 20 parts of safflower carthamus, 25 parts of kadsura pepper stems, 20 parts of cynanchum paniculatum, 15 parts of teasel roots, 15 parts of radix clematidis and 5 parts of liquorice. The medicine composition can treat prolapse of the lumbar intervertebral disc.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of prolapse of lumbar intervertebral disc and its preparation method and application.
Background technology
Prolapse of lumbar intervertebral disc is one of comparatively common illness, mainly because lumbar intervertebral disc each several part (vertebral pulp, fibrous ring and cartilaginous lamina), especially vertebral pulp, after having degenerative change in various degree, under the effect of external force factor, the Anular disruption of intervertebral disc, nucleus pulposus is from part outstanding (or deviating from) of breaking in rear or intraspinal tube, adjacent ridge nerve root is caused to be stimulated or oppress, thus generation flank pain, a series of clinical symptoms such as side lower limb or two numbness of lower limbs, pain.Prolapse of lumbar intervertebral disc is the highest with waist 4-5, waist 5-sacrum 1 sickness rate, accounts for 95%.For this reason, be bursting to and develop the needs that more medicines for the treatment of prolapse of lumbar intervertebral disc safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of prolapse of lumbar intervertebral disc disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of prolapse of lumbar intervertebral disc, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Thalictri Ramosi 28 parts, Radix Indigoferae hancockii 20 parts, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 25 parts, Herba Lespedezae Cuneatae 18 parts, Radix Fici Simplicissimae 26 parts, Radix Angelicae Sinensis 18 parts, Squama Manis 20 parts, Radix Paeoniae Rubra 25 parts, Herba Centipedae 25 parts, Myrrha 20 parts, ophidia 20 parts, 20 parts, Flos Carthami, Caulis Piperis Kadsurae 25 parts, Radix Cynanchi Paniculati 20 parts, Radix Dipsaci 15 parts, Radix Clematidis 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of prolapse of lumbar intervertebral disc, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of prolapse of lumbar intervertebral disc, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment prolapse of lumbar intervertebral disc medicine being used for the treatment of prolapse of lumbar intervertebral disc.
Herba Thalictri Ramosi is that Ranunculaceae thalictrum spp racemosus Thalictrum aquilegifolium L. var. sibiricum Regel ThalictrumramosumBoivin is with all herbal medicine.Summer gathers, and cleans and dries.Hardship, cold.Clearing away heat-damp and promoting diuresis, removing toxic substances.For conjunctival congestion and swelling pain, dysentery, hepatitis; Fracture is controlled in external, carbuncle furuncle and phyma poison.Wild Herba Ixeritis Denticulatae: heat-clearing and toxic substances removing, eliminating stasis to stop pain, hemostasis, leukorrhagia stopping.For cervical erosion, leukorrhagia, metrorrhagia, lower lower limb lymphangitis, traumatic injury, innominate toxic swelling, acute mastitis furuncle and phyma, burn and scald, trichomonal vaginitis.
Radix Indigoferae hancockii is the root of leguminous plant thin,tough silk hair Drymotaenium miyoshianum (Mak.) Mak., and Latin is called IndigoferahancockiiCraib, dispels the wind, pathogenic fire purging, pain relieving.Cure mainly gingivitis; Traumatic injury; Leprosy.
Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii is Herb or the root of ranunculaceae plant five leaf Radix clematidis floridae.Classification system is Clematis-quinquefoliolata-Hutch, expelling wind and removing dampness, and warming middle-JIAO is regulated the flow of vital energy, eliminating stasis to stop pain.For Fengshi Guanjie pain, traumatic injury, bruise, stomachache, dysmenorrhea, migraine, neuralgia, facial paralysis, fishbone bone stuck in the throat.The present invention is used as medicine with Herb.
Herba Lespedezae Cuneatae, formal name used at school: ClematishexapetalaPall.var.tchefouensis (Debeaux) S.Y.Hu, belongs to Ranales, the upright draft of Ranunculaceae, high 30-100 many centimetres.Root reddish tan.Branch is thin, has vertical rib and pubescence.Leaf alternate, pinniform 3 lobule, petiole is short, and total bennet is extremely short.9 ~ October result, fruit be pod, width egg shape or subsphaeroidal, is about 3.5 millimeters, and wide 2.5 millimeters, peel has submissive pubescence.Clearing away heat-damp and promoting diuresis, helps digestion except long-pending, expelling phlegm for arresting cough.For infantile malnutrition, dyspepsia, gastroenteritis, bacillary dysentery, stomachache, icterohepatitis, oedema due to nephritis, leucorrhea, stomatitis, cough, bronchitis; Herpes zoster is controlled in external, venom.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: prolapse of lumbar intervertebral disc belongs to the category of impediment syndrome, pain card, lumbago more, is frequently-occurring disease common clinically.Normal recurrent exerbation, obstinate, directly affects life and the work of patient.Herba Thalictri Ramosi of the present invention, Radix Indigoferae hancockii, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii, Herba Lespedezae Cuneatae, Radix Fici Simplicissimae, Radix Angelicae Sinensis heat-clearing and toxic substances removing, dredging collateral are invigorated blood circulation as monarch drug, Squama Manis, Radix Paeoniae Rubra, Herba Centipedae, Myrrha, ophidia, Flos Carthami, Caulis Piperis Kadsurae, Radix Cynanchi Paniculati, Radix Dipsaci, Radix Clematidis blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment prolapse of lumbar intervertebral disc successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1, the preparation of granule embodiment: get Herba Thalictri Ramosi 28g, Radix Indigoferae hancockii 20g, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 25g, Herba Lespedezae Cuneatae 18g, Radix Fici Simplicissimae 26g, Radix Angelicae Sinensis 18g, Squama Manis 20g, Radix Paeoniae Rubra 25g, Herba Centipedae 25g, Myrrha 20g, ophidia 20g, Flos Carthami 20g, Caulis Piperis Kadsurae 25g, Radix Cynanchi Paniculati 20g, Radix Dipsaci 15g, Radix Clematidis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
Embodiment 2, the preparation of Tablets Example: get Herba Thalictri Ramosi 28g, Radix Indigoferae hancockii 20g, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 25g, Herba Lespedezae Cuneatae 18g, Radix Fici Simplicissimae 26g, Radix Angelicae Sinensis 18g, Squama Manis 20g, Radix Paeoniae Rubra 25g, Herba Centipedae 25g, Myrrha 20g, ophidia 20g, Flos Carthami 20g, Caulis Piperis Kadsurae 25g, Radix Cynanchi Paniculati 20g, Radix Dipsaci 15g, Radix Clematidis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
Embodiment 3, the preparation of capsule embodiment: get Herba Thalictri Ramosi 28g, Radix Indigoferae hancockii 20g, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 25g, Herba Lespedezae Cuneatae 18g, Radix Fici Simplicissimae 26g, Radix Angelicae Sinensis 18g, Squama Manis 20g, Radix Paeoniae Rubra 25g, Herba Centipedae 25g, Myrrha 20g, ophidia 20g, Flos Carthami 20g, Caulis Piperis Kadsurae 25g, Radix Cynanchi Paniculati 20g, Radix Dipsaci 15g, Radix Clematidis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment prolapse of lumbar intervertebral disc of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation prolapse of lumbar intervertebral disc case 100 example, 46 ~ 57 years old age.The shortest person of the course of disease 6 months, most elder reaches 3 years.
4.2 diagnostic criterias: 1), skelalgia is more serious than lumbago, typical sciatica of nerve roots.2), lower limb paraesthesia, single nerve root is at lower limb or foot paralgia (waist 5, sacrum 1 or waist 4 spinal nerve root areal area) 3), lower spinal nerves root involves sign: 1. straight-leg raising test is less than 50 °.2. leg raising straight strengthens test for positive.3. strong limb raises the test positive.Above three kinds of signs must have a kind of for positive.4), in neurological physical examination, amyotrophy, myasthenia, paraesthesia and reflection change four kinds have two kinds for positive.5) the unenhanced or waist nuclear magnetic resonance check of, myelography, lumbar intervertebral disc CT is positive findings and is consistent with the clinical symptoms of nerve root of getting involved and sign.Above five standards are the positive, just can make Diagnosis of Lumber Disc Prolapse.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule one month is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: clinical symptom disappearance, local movement freely, is recovered normally to work, and x line check prolapse of lumbar intervertebral disc disease does not have growth, follows up a case by regular visits to without recurrence after 1 year.Effective: clinical symptoms disappears substantially, local movement, without obviously limited, can recover original work.Effective: clinical symptoms is obviously improved, tired or can symptom be occurred after catching cold, but comparatively before alleviate to some extent, lighter work can be participated in.Invalid: 2 ~ 3 courses for the treatment of are treated in medication, clinical symptoms is improved not obvious, and joint movement disorder is unchanged, very then increases the weight of.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 50 | 15 | 12 | 18 | 5 | 90 |
| Blank group | 50 | 0 | 1 | 1 | 48 | 4 |
Visible, the medicine that the present invention obtains can safe and effective treatment prolapse of lumbar intervertebral disc, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of prolapse of lumbar intervertebral disc, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Thalictri Ramosi 28 parts, Radix Indigoferae hancockii 20 parts, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 25 parts, Herba Lespedezae Cuneatae 18 parts, Radix Fici Simplicissimae 26 parts, Radix Angelicae Sinensis 18 parts, Squama Manis 20 parts, Radix Paeoniae Rubra 25 parts, Herba Centipedae 25 parts, Myrrha 20 parts, ophidia 20 parts, 20 parts, Flos Carthami, Caulis Piperis Kadsurae 25 parts, Radix Cynanchi Paniculati 20 parts, Radix Dipsaci 15 parts, Radix Clematidis 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of prolapse of lumbar intervertebral disc as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of prolapse of lumbar intervertebral disc as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment prolapse of lumbar intervertebral disc medicine of prolapse of lumbar intervertebral disc according to claim 1.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104784418A (en) * | 2015-04-24 | 2015-07-22 | 臧孝国 | Medicine for curing protrusion of lumbar intervertebral disc |
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| CN104784418A (en) * | 2015-04-24 | 2015-07-22 | 臧孝国 | Medicine for curing protrusion of lumbar intervertebral disc |
Non-Patent Citations (2)
| Title |
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| 冯小映等: "跌打消肿散治疗腰椎间盘突出临床疗效观察", 《中药材》 * |
| 陈利国: "仙方二活汤治疗急性腰椎间", 《陕西中医》 * |
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Application publication date: 20151223 |