CN105147906A - Traditional Chinese medicine for treating primary osteoporosis caused by qi deficiency of spleen and stomach and preparation method of traditional Chinese medicine - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating primary osteoporosis caused by qi deficiency of spleen and stomach and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following active pharmaceutical ingredients: panicled fameflower root, herb of waterlettuce, amur ampelopsis stem, stephanandra chinensis, all grass of pretty clubmoss, brassica campestris, sowthistle tasselflower herb, leaf of shortstyle cratoxylum, spina gleditsiae, hibiscus rosa-sinensis, cedarwood, balsamiferou blumea herb, adiantum capillus-veneris, edgeworthia chrysantha, leaf of whitebackleaf mallotus and stem or leaf of shrub lespedeza. The traditional Chinese medicine has the advantages of being high in pertinency, free from toxic or/and side effects, and efficient when used for treating primary osteoporosis caused by qi deficiency of spleen and stomach.

Description

A kind of Chinese medicine and preparation method for the treatment of qi-deficiency of spleen and stomach primary osteoporosis

Technical field

The present invention relates to pharmaceutical technology, particularly relate to a kind of Chinese medicine and preparation method for the treatment of qi-deficiency of spleen and stomach primary osteoporosis.

Background technology

Osteoporosis (osteoporosis, OP) be a kind of to reduce with bone amount, osseous tissue shows emblem structure degradation, and (Grafting Cancellous Bone Bolt girder attenuates, rupture, quantity minimizing; Cortical bone porous, thinning be feature), so that bone fragility increase and fracture risk increase a kind of general osteopathia.Along with the arrival of aging society, osteoporosis becomes the problem of worldwide extensive concern gradually.Osteoporosis has constitutional and Secondary cases two class.Primary osteoporosis has postmenopausal osteoporosis (I type) and senile osteoporosis (II type).Along with the development of history and the progress of science and technology, the understanding of people to osteoporosis is deepened gradually.Common osteoporosis clinical symptoms be in various degree, the skeleton of different parts and arthralgia, most can with waist skelasthenia, two lower limb are twitched, and bend over, turn round, squat down, the joint motion difficulty or obviously limited such as walking.The current whole world about has 200,000,000 people to suffer from osteoporosis, its sickness rate leapt to commonly encountered diseases, the 7th of frequently-occurring disease.Along with the aging of population, primary osteoporosis sickness rate raises year by year, and therefore, the preventing and controlling of osteoporosis are very important, how to carry out effectively preventing to osteoporosis, are the focuses of medical circle research always.

Modern medicine thinks that osteoporosis is along with social progress, aged tendency of population, bone mass retrogression of nature, bone strength is impaired, bone loss, a kind of generalized metabolic skeletal diseases causing fracture risk to increase, old women sickness rate is up to 90.48%, and elderly men reaches 60.72%.Along with the age increases, physical exertion reduces, muscle disuse atrophy, make the stress of osseous tissue more and more less, the invisible Progressive symmetric erythrokeratodermia of sclerotin is degenerated, bone mineral content reduces, especially old women, and the decline of estrogen level and quantity of motion reduce direct systemic hormonal readiness and regulate and various nutrition, vitamin, the absorption of trace element and metabolism campaign and this disease occurs.Patient's sore waist and aching in the waist and the back after morbidity, myasthenia of limbs, being reluctant dare not be movable, and elderly patient is poor to pain sensitivity, thinks that older reason is not gone to a doctor, and easily causes wrong diagnosis and escape, causes aggravation.

Because the etiology and pathology mechanism of osteoporosis is complicated, lacks single-minded specific short clinically, cause the multiformity that it is treated.The osteoporotic Western medicine of current treatment is divided three classes bone resorption inhibitor as estrogen, calcitonin, the bone formation-promoters such as diphosphate as fluoride, the bone mineralising promoter such as parathyroid hormone as calcium, vitamin etc.But said medicine but exists or side effect is comparatively large, Long-Term Safety is poor, or expensive, or the concrete mechanism of action is unclear, can not solve to recover oneself and lose the inevitably problem such as part bone amount.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of determined curative effect and the Chinese medicine of the little treatment qi-deficiency of spleen and stomach primary osteoporosis of side effect and preparation method.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of qi-deficiency of spleen and stomach primary osteoporosis, comprising following raw medicinal material: Radix Talini Paniculati; Herba Pistiae, Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae), joint joint tea; Herba Lycopodii pulcherrimi, Caulis et Folium Brassicae campestris, Herba Emiliae; Folium cratoxyli ligustrini, Spina Gleditsiae, Flos Hibisci Rosae-Sinensis; Lignum seu Ramulus Cunninghamiae Lanceolatae, Balsamiferou Blumea Herb, Herba Adianti; Edgeworthia chrysantha Lindl., Folium Malloti Apeltae and Caulis Seu Folium Lespedezae Bicoloris.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Talini Paniculati 15 ~ 25 parts, Herba Pistiae 10 ~ 20 parts; Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 5 ~ 15 parts, joint joint tea 20 ~ 30 parts, Herba Lycopodii pulcherrimi 10 ~ 20 parts; Caulis et Folium Brassicae campestris 20 ~ 30 parts, Herba Emiliae 15 ~ 25 parts, Folium cratoxyli ligustrini 20 ~ 30 parts; Spina Gleditsiae 10 ~ 20 parts, Flos Hibisci Rosae-Sinensis 20 ~ 30 parts, Lignum seu Ramulus Cunninghamiae Lanceolatae 5 ~ 15 parts; Balsamiferou Blumea Herb 20 ~ 30 parts; Herba Adianti 20 ~ 30 parts, Edgeworthia chrysantha Lindl. 10 ~ 20 parts, Folium Malloti Apeltae 10 ~ 20 parts and Caulis Seu Folium Lespedezae Bicoloris 20 ~ 30 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Talini Paniculati 17 ~ 22 parts, Herba Pistiae 10 ~ 15 parts; Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 8 ~ 13 parts, joint joint tea 20 ~ 25 parts, Herba Lycopodii pulcherrimi 15 ~ 20 parts; Caulis et Folium Brassicae campestris 22 ~ 27 parts, Herba Emiliae 17 ~ 22 parts, Folium cratoxyli ligustrini 23 ~ 28 parts; Spina Gleditsiae 10 ~ 15 parts, Flos Hibisci Rosae-Sinensis 25 ~ 30 parts, Lignum seu Ramulus Cunninghamiae Lanceolatae 8 ~ 13 parts; Balsamiferou Blumea Herb 22 ~ 27 parts; Herba Adianti 20 ~ 25 parts, Edgeworthia chrysantha Lindl. 13 ~ 18 parts, Folium Malloti Apeltae 10 ~ 15 parts and Caulis Seu Folium Lespedezae Bicoloris 25 ~ 30 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Talini Paniculati 21 parts, Herba Pistiae 10 parts; Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 12 parts, joint joint tea 21 parts, Herba Lycopodii pulcherrimi 20 parts; Caulis et Folium Brassicae campestris 22 parts, Herba Emiliae 20 parts, Folium cratoxyli ligustrini 24 parts; Spina Gleditsiae 14 parts, Flos Hibisci Rosae-Sinensis 26 parts, Lignum seu Ramulus Cunninghamiae Lanceolatae 12 parts; Balsamiferou Blumea Herb 23 parts; Herba Adianti 24 parts, Edgeworthia chrysantha Lindl. 14 parts, Folium Malloti Apeltae 15 parts and Caulis Seu Folium Lespedezae Bicoloris 26 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Talini Paniculati 18 parts, Herba Pistiae 13 parts; Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 10 parts, joint joint tea 25 parts, Herba Lycopodii pulcherrimi 16 parts; Caulis et Folium Brassicae campestris 26 parts, Herba Emiliae 18 parts, Folium cratoxyli ligustrini 26 parts; Spina Gleditsiae 10 parts, Flos Hibisci Rosae-Sinensis 28 parts, Lignum seu Ramulus Cunninghamiae Lanceolatae 9 parts; Balsamiferou Blumea Herb 26 parts; Herba Adianti 20 parts, Edgeworthia chrysantha Lindl. 18 parts, Folium Malloti Apeltae 10 parts and Caulis Seu Folium Lespedezae Bicoloris 30 parts.

Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

Beneficial effect of the present invention: Chinese medicine of the present invention to treatment qi-deficiency of spleen and stomach primary osteoporosis pointed strong, have no side effect, advantage that effective percentage is high.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of qi-deficiency of spleen and stomach primary osteoporosis, comprise following raw medicinal material: Radix Talini Paniculati, Herba Pistiae, Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae), joint joint tea, Herba Lycopodii pulcherrimi; Caulis et Folium Brassicae campestris, Herba Emiliae, Folium cratoxyli ligustrini, Spina Gleditsiae, Flos Hibisci Rosae-Sinensis; Lignum seu Ramulus Cunninghamiae Lanceolatae, Balsamiferou Blumea Herb, Herba Adianti, Edgeworthia chrysantha Lindl., Folium Malloti Apeltae and Caulis Seu Folium Lespedezae Bicoloris.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Radix Talini Paniculati: [another name] ginseng grass, native Korean Ginseng, Panax pseudoginseng Wall., Silene tatarinowii Regel-Melandrium tatarinwiii (Regel) Tsui., soil ginseng, purple Radix Ginseng, watt hole head, Radix angelicae morii, reddle ginseng, the ginseng that flies here, watt ginseng, cone flower, Radix Talini Paniculati, Fructus Persicae ginseng, the period of the day from 3 p.m. to 5 p.m. are spent.[source] medical material Ji Yuan: be the root of portulacaceous plant smoke tree orchid.[nature and flavor] are sweet; Light; Property is put down.[return through] spleen; Lung; Kidney channel.[function cures mainly] qi invigorating and lung moistening; Cough-relieving; Regulating menstruation.Main deficiency of vital energy sesame is tired; Lack of appetite; Have loose bowels; Pulmonary tuberculosis hemoptysis; Dizzy; Hectic fever; Night sweat; Spontaneous perspiration; Menoxenia; Leukorrhagia, paturient's hypogalactia.[extracts] " China's book on Chinese herbal medicine "

Herba Pistiae: [another name] water lettuce, sky Herba Spirodelae, water Herba Spirodelae; Large Pu algae, floating Piao, Herba Spirodelae, connect flower Piao, water-white dish, straw bag grass, water whip Rong, turn over duckweed, large kind of duckweed, water He Lian, Bulbophylulm ambrosirm (Hance) Schlir. (Bulbophyllum wat-sonianum Heichb. F.), red Caulis et Folium Lactucae sativae.[source] medical material Ji Yuan: be the herb of the large Piao of aroid.[nature and flavor] acrid in the mouth; Cold in nature.[return through] lung; Spleen; Liver Channel.[function cures mainly] dispelling wind and promoting eruption; Promoting urination to remove dampness; Removing heat from blood and promoting blood circulation.Main anemopyretic cold; Single board computer rash is not saturating; Urticaria; Heat in blood pruritus; Juice speckle; Eczema; Edema; Dysuria; Rheumatic arthralgia; Ecthyma; Erysipelas; Innominate toxic swelling; Treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae): [another name] sour rattan, Vitis Amurensis, parthenocissus, Radix vitis romanetii, pyrotechnics rattan, sky, mountain trailing plants, Cortex Ampelopsis Aconitifoliae Radicis, female bitter rattan, sour ancient rattan, standing grain Caulis Fibraureae, standing grain sow sub-rattan, green grapes, Cortex vitis balanseanae radicis, water Fructus Vitis viniferae.[source] medical material Ji Yuan: be the stem and leaf of vitaceae Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae).[nature and flavor] are bitter; Cool.[return through] heart; Liver; Kidney channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Dissipating blood stasis stops blooding; Removing toxic substances.Main oedema due to nephritis; Dysuria; Rheumatic arthralgia; Traumatic injury congestive edema; Hemorrhage due to internal injury; Sore.[extracts] " China's book on Chinese herbal medicine "

Joint joint tea: [another name] Shi Jiefeng, Herba Pileae Scriptae, wild Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.).[source] medical material Ji Yuan: be the herb of Chloranthaceae plant Chloranthus elatior.[nature and flavor] are pungent; Micro-hardship; Temperature.[function cures mainly] expelling wind and cold; Dredge the meridian passage; Hemostasis.Main anemofrigid cold; Headache; Rheumatic arthralgia; Numb limbs and tense tendons; Damaged bone is analysed; Puerperal hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Herba Lycopodii pulcherrimi: [source] medical material Ji Yuan: be the herb of lycopsid Herba Lycopodii pulcherrimi.[nature and flavor] are micro-pungent; Temperature.[return through] lung meridian.[function cures mainly] rash is detoxified; Active blood stasis dispelling.Main traumatic injury; Innominate toxic swelling; Measles without adequate eruption.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Caulis et Folium Brassicae campestris: [another name] Caulis et Folium Brassicae campestris, cold dish, a kind of sedge dish, Caulis et Folium Brassicae campestris dish, a kind of sedge mustard, green vegetable, chilli oil dish.[source] medical material Ji Yuan: be the root of crucifer Brassica campestris L, stem and leaf.[nature and flavor] are pungent; Sweet; Property is put down.[return through] lung; Liver; Spleen channel.[function cures mainly] removing pathogenic heat from blood and dissipating blood stasis; Removing toxic substances and promoting subsidence of swelling.Main dysentery; Erysipelas; Hot carbuncle toxin; Acute mastitis; Rubella; Spit blood.[extracts] " China's book on Chinese herbal medicine "

Herba Emiliae: fourth, wild hardship are bought privately, rabbitweed, rabbit are joined, black furuncle is careless for [another name] purple back of the body grass, false cabbage mustard, firecracker grass, Radix seu Folium Alchorneae trewioidis, YEXIAHONG, the red grass of loudspeaker, little Herba Taraxaci, 72 flowers, oxtail knee joint, purple back of the body Herba Violae japonicae, goatweed, sky hair grass, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), wild cabbage mustard, milk grass, empty cylinder list, Flos Gomphrenae, purple.[source] medical material Ji Yuan: be the herb of feverfew Herba Duchesneae Indicae.[nature and flavor] bitter in the mouth; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Your Majesty's respiratory tract infection; Oral ulcer; Pneumonia; Mastitis; Intestinal is scorching; Bacillary dysentery; Urinary tract infection; Furuncle carbuncle; Eczema; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Folium cratoxyli ligustrini: [another name] yellow bud wood, passeris montani saturati cage wood.[source] medical material Ji Yuan: be the stem and leaf of Garcinia maingayii cattle wood, root or bark.[nature and flavor] are sweet light; Micro-hardship; Cool.[return through] lung; Stomach; Large intestine channel.[function cures mainly] heat-clearing and toxic substances removing; Removing dampness disappears stagnant; Removing blood stasis to reduce swelling.Main flu; Heatstroke is generated heat; Have loose bowels; Jaundice; Traumatic injury; Carbuncle furuncle; Tender leaf makes refreshment drink; Summer-heat excessive thirst can be separated.[extracts] " China's book on Chinese herbal medicine "

Spina Gleditsiae: [another name] Fructus Gleditsia acupuncture, Spina Gleditsiae, sky fourth, SPINA GLEDITSIAE, soap pin.[source] medical material Ji Yuan: be the Spina jujubae of leguminous plant Fructus Gleditsia.[nature and flavor] are pungent; Temperature.[return through] liver; Lung meridian.[function cures mainly] sterilizes pus; Search wind; Parasite killing.Main swollen ulcer drug; Scrofula; Skin ulcer rash stubborn dermatitis; Puerperal hypogalactia; Placenta retention; Leprosy.[extracts] " China's book on Chinese herbal medicine "

Flos Hibisci Rosae-Sinensis: [another name] is taken, Caulis et folium clerodendri bungei, hang spring Flos Carthami, Folium Lantanae Camarae, bright red Flos Moutan, fuchsia, wood flower, friend is red, cock is colored, Buddhist Flos Mori, crafty headdress flower, Skapanthus C.Y.Wu et H.W.Li,nom.nov., ZHUANGYUANHONG.[source] medical material Ji Yuan: be the flower of Malvaceae plant Hibiscus rosasinensis.[nature and flavor] are sweet; Light; Flat.[return through] heart; Lung; Liver; Spleen channel.[function cures mainly] lung heat clearing; Removing heat from blood; Removing dampness; Removing toxic substances.Main cough due to lung-heat; Spitting of blood; Epistaxis; Metrorrhagia; Leucorrhea; Dysentery; Reddish and whitish turbid urine; Carbuncle skin infection.[extracts] " China's book on Chinese herbal medicine "

Lignum seu Ramulus Cunninghamiae Lanceolatae: [another name] China fir, Cunninghamia lanceolata (Lamb.) Hook., positive China fir, thorn China fir, sky Scolopendra, thousand are cutter.[source] is Taxodiaceae genus Taxus Lignum seu Ramulus Cunninghamiae Lanceolatae Cunninghamialanceolata (Lamb.) Hook., is used as medicine with root, bark, cone, timber, leaf and China fir joint.The four seasons can adopt, using fresh herb or dry for subsequent use.[nature and flavor] are pungent, tepor.[function cures mainly] wind-expelling pain-stopping, dissipating blood stasis stops blooding.For chronic tracheitis, stomachache, rheumatic arthritis; Traumatic injury is controlled in external, burn and scald, traumatic hemorrhage, allergic dermatitis.[extracts] " national Chinese herbal medicine compilation "

Balsamiferou Blumea Herb: [another name] Herba Blumeae Balsamiferae, Borneolum Syntheticum end.[source] is Compositae Herba Blumeae Balsamiferae platymiscium Balsamiferou Blumea Herb BlumeabalsamiferaDC., is used as medicine with root, twig, leaf.Xia Qiu gathers, using fresh herb or dry in the shade.[nature and flavor] pungent, micro-hardship, tepor.[function cures mainly] dispels the wind detumescence, promoting blood circulation to remove blood stasis.For flu, rheumatic arthritis, puerperal exposure to wind pain, dysmenorrhea; Traumatic injury is controlled in external, furuncle carbuncle, eczema, dermatitis.[extracts] " national Chinese herbal medicine compilation "

Herba Adianti: [another name] Shi Zhongzhu, Pilus Sus domestica paint, iron wire grass, bristles paint, Herba Hemiboeae, piglets MAOQI, rock Herba Spirodelae, Pilus Sus domestica false aloe, Herba cynodontis, fish scale grass, black foot awns, Pilus Sus domestica seven, rock palm fibre, the comprehensive grass of pig, Herba cynodontis, iron wire button, Shi Zhongzhu, Pilus Sus domestica paint, Adiantum monochlamys, black hair are returned to life from the nether world, touched grass, ferrum bachelor, iron wire parting, water Pilus Sus domestica seven, pig palm fibre seven, bristles seven, blackwort symphytum, flabellum venushair fern, Herba Parnassiae Delavayi, Yan Jia, besom beanstalk, gagger wolf beanstalk.[source] medical material Ji Yuan: be the herb of adiantaceae plant iron Colysis ellipiica (Thunb.) Chingpolypodium ellipticum Thumb., white back iron Colysis ellipiica (Thunb.) Chingpolypodium ellipticum Thumb..[nature and flavor] are bitter; Cool; Nontoxic.[return through] liver; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Relieving stranguria by diuresis.Main cold, fever; Cough due to lung-heat; Diarrhea due to damp-heat; Dysentery; Stranguria with turbid discharge; Leukorrhagia; Acute mastitis; Scrofula; Furunculosis; Scald; Venom.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Edgeworthia chrysantha Lindl.: [another name] wild Flos Buddlejae, new Flos Buddlejae.[source] thymelaeceae Edgeworthia chrysantha Lindl. platymiscium Edgeworthia chrysantha Lindl., is used as medicine with root and flower.Xia Qiucaigen; Spring picks flowers, and dries or using fresh herb.[nature and flavor] are sweet, temperature.[function cures mainly] root: relaxing muscles and tendons and activating QI and blood in the collateral, reducing swelling and alleviating pain.For rheumatic arthralgia, lumbago; Traumatic injury is controlled in external, fracture.Flower: dispelling pathogenic wind for improving eyesight.For conjunctival congestion and pain of eye, nyctalopia.[extracts] " national Chinese herbal medicine compilation "

Folium Malloti Apeltae: [another name] white crane leaf, flour halberd, flour wind, white Folium Persicae.[source] medical material Ji Yuan: be the leaf of euphorbia plant Folium Malloti Apeltae.[nature and flavor] bitter in the mouth; Property is put down.[return through] liver; Spleen channel.[function cures mainly] heat clearing away; Removing toxic substances; Damp eliminating; Hemostasis.Main cellulitis; Suppurative otitis media; Thrush; Eczema; Traumatic injury; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Caulis Seu Folium Lespedezae Bicoloris: [another name] go along with an army tea, sweep skin, recklessly branch, Herba cassiae torae, Cortex Ampelopsis Aconitifoliae Radicis, the Cornu Caprae seu Ovis tip, bean leaf bavin, silk tree grass, artificial flower raw horizontal stripe, horizontal basketry, sweep bar.[source] medical material Ji Yuan: be the branch and leaf of leguminous plant Caulis Seu Folium Lespedezae Bicoloris.[nature and flavor] are sweet; Flat.[return through] heart; Liver Channel.[function cures mainly] clearing heat and moistening lung; Inducing diuresis for treating stranguria syndrome; Hemostasis.Main cough due to lung-heat; Cold, fever; Pertussis; Stranguria; Spit blood; Epistaxis; Hematuria; Have blood in stool.[extracts] " China's book on Chinese herbal medicine "

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Talini Paniculati 15 ~ 25 parts, Herba Pistiae 10 ~ 20 parts; Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 5 ~ 15 parts, joint joint tea 20 ~ 30 parts, Herba Lycopodii pulcherrimi 10 ~ 20 parts; Caulis et Folium Brassicae campestris 20 ~ 30 parts, Herba Emiliae 15 ~ 25 parts, Folium cratoxyli ligustrini 20 ~ 30 parts; Spina Gleditsiae 10 ~ 20 parts, Flos Hibisci Rosae-Sinensis 20 ~ 30 parts, Lignum seu Ramulus Cunninghamiae Lanceolatae 5 ~ 15 parts; Balsamiferou Blumea Herb 20 ~ 30 parts; Herba Adianti 20 ~ 30 parts, Edgeworthia chrysantha Lindl. 10 ~ 20 parts, Folium Malloti Apeltae 10 ~ 20 parts and Caulis Seu Folium Lespedezae Bicoloris 20 ~ 30 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Talini Paniculati 17 ~ 22 parts, Herba Pistiae 10 ~ 15 parts; Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 8 ~ 13 parts, joint joint tea 20 ~ 25 parts, Herba Lycopodii pulcherrimi 15 ~ 20 parts; Caulis et Folium Brassicae campestris 22 ~ 27 parts, Herba Emiliae 17 ~ 22 parts, Folium cratoxyli ligustrini 23 ~ 28 parts; Spina Gleditsiae 10 ~ 15 parts, Flos Hibisci Rosae-Sinensis 25 ~ 30 parts, Lignum seu Ramulus Cunninghamiae Lanceolatae 8 ~ 13 parts; Balsamiferou Blumea Herb 22 ~ 27 parts; Herba Adianti 20 ~ 25 parts, Edgeworthia chrysantha Lindl. 13 ~ 18 parts, Folium Malloti Apeltae 10 ~ 15 parts and Caulis Seu Folium Lespedezae Bicoloris 25 ~ 30 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Talini Paniculati 21 parts, Herba Pistiae 10 parts; Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 12 parts, joint joint tea 21 parts, Herba Lycopodii pulcherrimi 20 parts; Caulis et Folium Brassicae campestris 22 parts, Herba Emiliae 20 parts, Folium cratoxyli ligustrini 24 parts; Spina Gleditsiae 14 parts, Flos Hibisci Rosae-Sinensis 26 parts, Lignum seu Ramulus Cunninghamiae Lanceolatae 12 parts; Balsamiferou Blumea Herb 23 parts; Herba Adianti 24 parts, Edgeworthia chrysantha Lindl. 14 parts, Folium Malloti Apeltae 15 parts and Caulis Seu Folium Lespedezae Bicoloris 26 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Talini Paniculati 18 parts, Herba Pistiae 13 parts; Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 10 parts, joint joint tea 25 parts, Herba Lycopodii pulcherrimi 16 parts; Caulis et Folium Brassicae campestris 26 parts, Herba Emiliae 18 parts, Folium cratoxyli ligustrini 26 parts; Spina Gleditsiae 10 parts, Flos Hibisci Rosae-Sinensis 28 parts, Lignum seu Ramulus Cunninghamiae Lanceolatae 9 parts; Balsamiferou Blumea Herb 26 parts; Herba Adianti 20 parts, Edgeworthia chrysantha Lindl. 18 parts, Folium Malloti Apeltae 10 parts and Caulis Seu Folium Lespedezae Bicoloris 30 parts.

Wherein, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: tablet

Fetch earth Radix Ginseng 180g, Herba Pistiae 130g, Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 100g, joint joint tea 250g, Herba Lycopodii pulcherrimi 160g, Caulis et Folium Brassicae campestris 260g, Herba Emiliae 180g, Folium cratoxyli ligustrini 260g, Spina Gleditsiae 100g, Flos Hibisci Rosae-Sinensis 280g, Lignum seu Ramulus Cunninghamiae Lanceolatae 90g, Balsamiferou Blumea Herb 260g, Herba Adianti 200g, Edgeworthia chrysantha Lindl. 180g, Folium Malloti Apeltae 100g and Caulis Seu Folium Lespedezae Bicoloris 300g;

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 400 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.1 times of lactose, the starch of 0.1 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.03 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2: powder

Fetch earth Radix Ginseng 210g, Herba Pistiae 100g, Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 120g, joint joint tea 210g, Herba Lycopodii pulcherrimi 200g, Caulis et Folium Brassicae campestris 220g, Herba Emiliae 200g, Folium cratoxyli ligustrini 240g, Spina Gleditsiae 140g, Flos Hibisci Rosae-Sinensis 260g, Lignum seu Ramulus Cunninghamiae Lanceolatae 120g, Balsamiferou Blumea Herb 230g, Herba Adianti 240g, Edgeworthia chrysantha Lindl. 140g, Folium Malloti Apeltae 150g and Caulis Seu Folium Lespedezae Bicoloris 260g;

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders;

3rd step, adds the starch relative to its quality 2 times in the micropowders obtained by second step, mixing, obtains powder.

Toxicity test:

Acute toxicity test: the tablet prepared with the embodiment of the present invention 1 and the powder of the embodiment of the present invention 2 are dissolved in distilled water respectively, give 2 groups of white mice (often organizing 30) feeding dispensing respectively with 180 of clinical consumption per day times and 260 times respectively, observe 14; The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.Illustrate that Chinese medicine of the present invention is little to white mice acute use toxicity, application safety.

Long term toxicity test: the tablet embodiment of the present invention 1 prepared is dissolved in water by 16.26g crude drug/kg, the powder of the embodiment of the present invention 2 is dissolved in water by 34.54g crude drug/kg, continuous use 16 weeks are distinguished to 2 groups of mices (often organizing 20), every day 2 times, and drug withdrawal is after 4 weeks, result shows: Chinese medicine of the present invention is to the hair of 2 groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: fetch the 80 routine Osteoporosis coming from this Out-patient Department He be in hospital, male 48 people, female 32 people; 42 ~ 75 years old age, the course of disease 2 ~ 10 years; Postmenopausal osteoporosis (I type) patient 43 people, senile osteoporosis (II type) 37 people.80 routine patients are divided into treatment group and matched group at random, treatment group 40 people, male 25 people, female 15 people; 42 ~ 73 years old age, the course of disease 2 ~ 9 years; Postmenopausal osteoporosis (I type) patient 22 people, senile osteoporosis (II type) 18 people; Matched group 40 people, male 23 people, female 17 people; 44 ~ 75 years old age, the course of disease 3 ~ 10 years; Postmenopausal osteoporosis (I type) patient 21 people, senile osteoporosis (II type) 19 people.

Diagnostic criteria: " Chinese's osteoporosis suggestion diagnostic criteria (the second original text) " formulated according to WHO osteoporosis standard and osteoporosis committee of Aged in China association.

Syndrome Differentiation of Traditional Chinese Medicine standard: qi-deficiency of spleen and stomach: primary symptom: lumbar vertebrae pain, muscle is withered very thin, tired; Secondary disease: limbs are weak and feeble, gradually cause slow indulging and do not receive, anorexia and loose stool, or incessant chronic diarrhea, Mian Se Koushi is white, impractical simple and unadorned, palpitation and insomnia, notably aversion to cold and cold limbs, pale complexion, pale tongue, thready and weak pulse without strength.

Exclusion standard: (1), eliminating endocrinopathy (as hyperthyroidism, hyperparathyroidism), the secondary osteoporosis that the diseases such as metabolic disease (as diabetes) cause; (2), important organ is merged: the heart, lung, brain, liver, gallbladder serious disease person; (3) medicine or multiple food anaphylaxis history person, is had; (4), psychological problem person; (5) heart, brain, liver, kidney and hemopoietic system severe primary disease patient is merged.

Therapeutic Method:

Treatment group: take tablet prepared by the embodiment of the present invention 1, every day 3 times, each 34 weeks is 1 course for the treatment of, takes 3 courses for the treatment of, once checks for 4 weeks.

Matched group: injection Calcitonin Salmon, first week: once a day, each 50 units; Second week: the next day once, each 50 units; 3rd thoughtful 12 week: weekly, each 100 units.Treatments period, according to the state of an illness, takes calcium constituent 0.5 ~ 1.0 gram every day, vitamin D4 00 unit; Within 4 weeks, once check.

Observation item and method:

Symptom, sign: lumbago and backache integration press lumbago and backache light, in, heavy indexing.Lumbago and backache continues and is seriously 3 points; Time light during lumbago and backache, heavy or recurrent exerbation person counts 2 points; Slightly or once in a while there is meter 1 point in lumbago and backache; It is 0 point that lumbago and backache disappears.

Bone densitometry: Dual-energy X-rays absorptionmetry, measurement site L1 ~ 4.

Curative effect determinate standard: formulate the standard of curative effect evaluation with reference to " osteoporosis ", employing nimodipine method [(after the front integration-treatment for the treatment of integration) front integration × 100% of/treatment.Effective: the symptoms such as lumbago and backache significantly take a turn for the better, the light and heavy degree integration of the state of an illness declines>=2/3, and rise after bone density value treatment 0.05g/cm ².Effective: the symptoms such as lumbago and backache take a turn for the better, the light and heavy degree integration decline>=1/3-2/3 of the state of an illness, right bone density increases < 0.05g/cm ².Invalid: symptom without improvement, or increases the weight of, the light and heavy degree integration decline of the state of an illness is less than 1/3, and bone density checks unchanged.

Statistical method: adopt SPSS11.0 statistics software processes.Measurement data represents with mean ± standard deviation (x ± s), and enumeration data adopts χ ²inspection, measurement data adopts t inspection, and P < 0.05 has statistical significance for difference.

Therapeutic outcome: see table 1, table 2 and table 3, as can be seen from Table 1, adopts treatment by Chinese herbs qi-deficiency of spleen and stomach primary osteoporosis of the present invention, relative to matched group on therapeutic effect, has significant improvement.As can be seen from Table 2, adopt treatment by Chinese herbs qi-deficiency of spleen and stomach primary osteoporosis of the present invention, relative to matched group, treatment the course for the treatment of on significantly shorten, take effect faster.As can be seen from Table 3, adopt treatment by Chinese herbs qi-deficiency of spleen and stomach primary osteoporosis of the present invention, relative to matched group, can bone density value be significantly improved.

Table 1 liang group treats Clinical efficacy comparison example (%) after 3 courses for the treatment of respectively

Group	n	Effective (%)	Effectively (%)	Invalid (%)	Total effective rate
						Treatment group	40	27(67.5％)	12(30％)	1(2.5％)	39(97.5％)
Matched group	40	20(50％)	15(37.5％)	5(12.5％)	35(87.5％)

As known from Table 1, the effective percentage of Chinese medicine of the present invention is 97.5%, and wherein obvious effective rate is 67.5%, is obviously better than matched group, through statistical procedures significant difference (P < 0.05).

Table 2 liang group treats effective number and time comparative example (%) after 3 courses for the treatment of respectively

Group	n	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of
					Treatment group	27	8(20％)	19(47.5％)	27(67.5％)
Matched group	20	4(10％)	13(32.5％)	20(50％)

According to the clinical statistics in above table, Chinese medicine provided by the invention has rapid-action, effective percentage and obvious effective rate is high, the advantage that has no side effect; Simultaneously to effective 27 examples for the treatment of group and the effective 20 routine follow-up of patients of matched group 1 year, result is added up, treatment group 27 example without recurrence or aggravation, the routine patient of matched group 20, recurrence or aggravation 2 people, relapse rate 10%.

Bone density value change (x ± s) (g/cm before and after table 3 osteoporosis treatment ²)

After treatment group medication, bone density value obviously rises, difference highly significant before and after medication; Treatment group compares with matched group, significant difference.

Model case: Zhao, female, 63 years old, suffers from postmenopausal osteoporosis 5 years, in conjunction with tcm symptom lumbar vertebrae pain, muscle is withered very thin, tired, and limbs are weak and feeble, gradually cause slow indulging not receive, anorexia and loose stool, palpitation and insomnia, pale complexion, pale tongue, thready and weak pulse without strength, diagnosis also typing is qi-deficiency of spleen and stomach postmenopausal osteoporosis: take Chinese medicine preparation embodiment 1 tablet of the present invention, every day 3 times, each 3, treat the symptoms such as 10 weeks lumbago and backache significantly to take a turn for the better, the light and heavy degree integration of the state of an illness declines>=2/3, and bone surfase density value is from the 0.683g/cm before treatment ²rise to the 0.902g/cm after treatment ², continue to take drug withdrawal after 2 weeks, follow up a case by regular visits to and do not recur or aggravation for 1 year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine for qi-deficiency of spleen and stomach primary osteoporosis, it is characterized in that, comprise following raw medicinal material: Radix Talini Paniculati; Herba Pistiae, Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae), joint joint tea; Herba Lycopodii pulcherrimi, Caulis et Folium Brassicae campestris, Herba Emiliae; Folium cratoxyli ligustrini, Spina Gleditsiae, Flos Hibisci Rosae-Sinensis; Lignum seu Ramulus Cunninghamiae Lanceolatae, Balsamiferou Blumea Herb, Herba Adianti; Edgeworthia chrysantha Lindl., Folium Malloti Apeltae and Caulis Seu Folium Lespedezae Bicoloris.

2. Chinese medicine as claimed in claim 1; it is characterized in that; in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Talini Paniculati 15 ~ 25 parts; Herba Pistiae 10 ~ 20 parts; Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 5 ~ 15 parts, joint joint tea 20 ~ 30 parts, Herba Lycopodii pulcherrimi 10 ~ 20 parts; Caulis et Folium Brassicae campestris 20 ~ 30 parts; Herba Emiliae 15 ~ 25 parts, Folium cratoxyli ligustrini 20 ~ 30 parts, Spina Gleditsiae 10 ~ 20 parts; Flos Hibisci Rosae-Sinensis 20 ~ 30 parts; Lignum seu Ramulus Cunninghamiae Lanceolatae 5 ~ 15 parts, Balsamiferou Blumea Herb 20 ~ 30 parts, Herba Adianti 20 ~ 30 parts; Edgeworthia chrysantha Lindl. 10 ~ 20 parts, Folium Malloti Apeltae 10 ~ 20 parts and Caulis Seu Folium Lespedezae Bicoloris 20 ~ 30 parts.

3. Chinese medicine as claimed in claim 1 or 2; it is characterized in that; in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Talini Paniculati 17 ~ 22 parts; Herba Pistiae 10 ~ 15 parts; Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 8 ~ 13 parts, joint joint tea 20 ~ 25 parts, Herba Lycopodii pulcherrimi 15 ~ 20 parts; Caulis et Folium Brassicae campestris 22 ~ 27 parts; Herba Emiliae 17 ~ 22 parts, Folium cratoxyli ligustrini 23 ~ 28 parts, Spina Gleditsiae 10 ~ 15 parts; Flos Hibisci Rosae-Sinensis 25 ~ 30 parts; Lignum seu Ramulus Cunninghamiae Lanceolatae 8 ~ 13 parts, Balsamiferou Blumea Herb 22 ~ 27 parts, Herba Adianti 20 ~ 25 parts; Edgeworthia chrysantha Lindl. 13 ~ 18 parts, Folium Malloti Apeltae 10 ~ 15 parts and Caulis Seu Folium Lespedezae Bicoloris 25 ~ 30 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Talini Paniculati 21 parts; Herba Pistiae 10 parts, Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 12 parts, joint joint tea 21 parts; Herba Lycopodii pulcherrimi 20 parts, Caulis et Folium Brassicae campestris 22 parts, Herba Emiliae 20 parts; Folium cratoxyli ligustrini 24 parts, Spina Gleditsiae 14 parts, Flos Hibisci Rosae-Sinensis 26 parts; Lignum seu Ramulus Cunninghamiae Lanceolatae 12 parts, Balsamiferou Blumea Herb 23 parts, Herba Adianti 24 parts; Edgeworthia chrysantha Lindl. 14 parts, Folium Malloti Apeltae 15 parts and Caulis Seu Folium Lespedezae Bicoloris 26 parts.

5. the Chinese medicine as described in claims 1 to 3, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Talini Paniculati 18 parts; Herba Pistiae 13 parts, Caulis seu folium ampelopsis brevipedunculatae (Caulis Ampelopsis Brevipedunculae) 10 parts, joint joint tea 25 parts; Herba Lycopodii pulcherrimi 16 parts, Caulis et Folium Brassicae campestris 26 parts, Herba Emiliae 18 parts; Folium cratoxyli ligustrini 26 parts, Spina Gleditsiae 10 parts, Flos Hibisci Rosae-Sinensis 28 parts; Lignum seu Ramulus Cunninghamiae Lanceolatae 9 parts, Balsamiferou Blumea Herb 26 parts, Herba Adianti 20 parts; Edgeworthia chrysantha Lindl. 18 parts, Folium Malloti Apeltae 10 parts and Caulis Seu Folium Lespedezae Bicoloris 30 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.