CN105106470A - Preparation for treating ovarian cancer and preparation method - Google Patents
Preparation for treating ovarian cancer and preparation method Download PDFInfo
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- CN105106470A CN105106470A CN201510601639.XA CN201510601639A CN105106470A CN 105106470 A CN105106470 A CN 105106470A CN 201510601639 A CN201510601639 A CN 201510601639A CN 105106470 A CN105106470 A CN 105106470A
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Abstract
The invention discloses a preparation for treating ovarian cancer and a preparation method. The preparation is prepared from the following main raw material drugs in parts by weight: 9-16 parts of agrimonia pilosa, 7-14 parts of roots of sandhill tylophora, 6-12 parts of blackberrylily rhizome, 8-15 parts of ficus erecta, 6-16 parts of rhizome of bipinnatifid ginseng, 9-15 parts of roots of actinidia eriantha Benth., 7-13 parts of papaya, 6-14 parts of oxyria sinensis, 9-13 parts of cortex magnoliae officinalis, 7-15 parts of roots of cicerbita cyanea, 9-14 parts of catharanthus roseus, 8-13 parts of viscum ovalifolium, 7-12 parts of roots of bilobed grewia, and 10-15 parts of cordyceps sinensis. The preparation is remarkable in curative effect, safe and free of toxic and side effects, has no harm to ovaries, can improve immunity of patients, inhibits and kills cancer cells, and enables tumors to gradually shrink and even disappear to prevent the diffusion and metastasis of tumors; moreover, through the adoption of the preparation, the ovarian cancer is not easy to relapse.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relating to a kind of preparation for curing ovarian cancer and method for making.
Background technology
Ovarian cancer is one of common malignant tumor of female sex organ, and sickness rate is only second to cervical cancer and carcinoma of uterine body and arranges the 3rd, residence.But ovarian epithelium mortality of carcinoma accounts for the first place of all kinds of gynecological tumor, serious threat is caused to women's life.The etiology unknown of ovarian cancer is true, may be relevant with the following aspects: pathogenesis of cancer external factor (comprising the cancerigenic factors such as chemistry, physics, biology); Pathogenesis of cancer internal factor (comprising immunologic function, endocrine, heredity, Nervous and Mental Factors etc.), and dietetic nutrition imbalance and bad life habits etc.The multiple women being born in climacteric.More than the 35 years old multiple epithelial ovarian cancers of person, and young and childhood, women mostly was sexual cell class malignant tumor.Clinical manifestation: 1, symptom: (1) pain.Malignant tumor of ovary may due to the change in tumor, as hemorrhage, downright bad, increase rapidly and cause the persistence distending pain of certain degree.Find that when checking there is tenderness its local.(2) menoxenia.Accidental Irregular uterine bleeding, pmb.(3) become thin.Late period is progressive emaciation.2. sign: (1) lower abdomen enclosed mass.The raw elder of granulosa tumor bilateral accounts for 75%, and benign ovarian tumor bilateral person only accounts for 15%.(2) seroperitoneum.Although benign ovarian tumor such as fibroma or papillary cystadenoma also can concurrent seroperitoneums, it is more that malignant tumor of ovary merges seroperitoneum person.If malignant cell passes peplos or has been transferred to peritoneum, seroperitoneum can in courageous and upright.(3) cachexia.The course of disease delays person more of a specified duration, owing to consuming for a long time, inappetence and showed progressive emaciation, weak, the cachectic symptoms such as asthenia.
Treatment: 1. Therapeutic Principle.Malignant tumor of ovary is the Comprehensive Treatments such as therapeutic scheme is different, multiplex operative treatment combined chemotherapy because histological type is different.2. operative treatment.First should detect in detail during operation, comprise the cytolgical examination of peritoneal fluid or seroperitoneum, the palpation of diaphragm, abdominopelvic cavity internal organs, pelvic lymph node, retroperitoneal lymph node, to carry out neoplasm staging accurately.The modus operandi of early stage patient is divided into comprehensive staging operation and retains the staging operation of reproductive function.The scope of comprehensive staging operation comprises bilateral adnexa, uterus, omentum majus excision and pelvic cavity and retroperitoneal lymph node dissection.Tumor is had to the end-stage patients of extensive Implantation matastasis at pelvic cavity, advocate to do surgical cytoreduction as far as possible.3. chemotherapy.Because malignant tumor of ovary especially epithelial cancer spreads very early, during operation, majority of cases can not remove focus, and the effect of radiotherapy and application also very limited, therefore systemic chemotherapy is an important auxiliary treating method.Especially malignant germ cell tumors, specification chemotherapy can significantly improve survival.Some end-stage patients, after chemotherapy, lump can reduce, and creates favorable conditions for satisfaction during operation subtracts tumor.4. radiotherapy.The radiation-sensitive gender gap of malignant tumor of ovary is very large, and Ovarian Endodermal Sinus Tumor, immature teratoma, embryonal carcinoma are least responsive, epithelial ovarian cancer and granular cell carcinoma medium sensitivity, and dysgerminoma is the most responsive, and Post operation controls with radiotherapy multipotency again.But because the malignant germ cell tumors such as dysgerminoma mostly are teenager and chemotherapy effect is good, the side effect of abdomen pelvic irradiation is comparatively large, and radiotherapy is rarely used in malignant tumor of ovary.
Application publication number CN102423369A(application number 201110449211.X) Chinese patent literature disclose a kind of prevention or treatment ovarian cancer Chinese medicine composition, it is formed by the active fraction preparation of following weight portion: Cortex Phellodendri 10-15 part, Fructus Arctii 10-15 part, Fructus Forsythiae 15-20 part, Herba Taraxaci 15-18 part, Rhizoma Chuanxiong 12-16 part, Ramulus Cinnamomi 12-16 part, Radix Et Rhizoma Rhei 10-15 part, Radix Rehmanniae 14-18 part, Hirudo 6-10 part.Application publication number CN103977347A(application number 201410191927.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of ovarian cancer, comprise Rhizoma Sparganii, Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Fructus Toosendan, Herba Salviae Chinensis, Rhizoma Corydalis, the Radix Linderae, the Radix Astragali, Endothelium Corneum Gigeriae Galli, Pollen Typhae, Radix Notoginseng, fries Endothelium corneum and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata).Application publication number CN104383464A(application number 201410757554.6) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of ovarian cancer, be prepared from by following raw material: the Rhizoma Pinelliae, Rhizoma Curcumae, the Rhizoma Atractylodis Macrocephalae, Myrrha, the Cortex Eucommiae, Semen Armeniacae Amarum, Radix Paeoniae Rubra, Radix Polygalae, Rhizoma Alismatis, Radix Dipsaci, Rhizoma Corydalis, Pheretima, the Radix Aucklandiae, Radix Codonopsis, Radix Curcumae, Herba Asari, Radix Bupleuri, Radix Angelicae Sinensis, Herba Taxilli, Radix Ginseng, Squama Manis, Radix Ophiopogonis, Radix Rehmanniae Preparata, Radix Angelicae Pubescentis, the Radix Astragali, Fructus Ligustri Lucidi, Semen Plantaginis, Spica Prunellae, Rhizoma Chuanxiong.Application publication number CN104352808A(application number 201410754013.8) Chinese patent literature disclose a kind of Chinese medicine water-honeyed pill for the treatment of ovarian cancer, be prepared from by following raw material: Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus, the Radix Linderae, the Radix Rehmanniae, Herba Dendrobii, Rhizoma Alismatis, Colla Corii Asini, Rhizoma Atractylodis, Olibanum, Ramulus Cinnamomi, Rhizoma Cimicifugae, Radix Sophorae Flavescentis, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Fructus Psoraleae, Rhizoma Dioscoreae, the Cortex Eucommiae, Eupolyphaga Seu Steleophaga, Poria, Pericarpium Arecae, Caulis Spatholobi, Concha Ostreae, Herba Patriniae, Rhizoma Drynariae, Herba Hedyotidis Diffusae and Radix Glycyrrhizae.
At present, the method for western medical treatment ovarian cancer is based on operative treatment, radiotherapy, chemotherapy or operative treatment combined chemotherapy.Although these therapy instant effects, can only solve local problem, have nocuity to ovary, after treatment, there is cancer cell metastasis equivalent risk in easily recurrence, and doctor trained in Western medicine is when applying radiotherapy, chemotherapy or front and back, often cause digestive tract reaction or bone marrow depression side reaction, side effect is large.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of preparation for curing ovarian cancer and method for making.The present invention is evident in efficacy, safely, has no side effect, not easily recurs, and to ovary fanout free region, can improve the immunocompetence of patient, cancer inhibitting and killing cell, make tumor reduce disappearance gradually, prevents its diffusion and transfer.
Technical scheme of the present invention is:
For curing the preparation of ovarian cancer, taking off the primary raw material medicine stating weight proportion and being prepared from: Herba Agrimoniae 9-16, Radix Tylophorae arenicolae 7-14, Rhizoma Belamcandae 6-12, Radix Fici beecheyanae 8-15, Rhizoma Panacis bipinnatifidi 6-16, Radix Actinidiae Erianthae root 9-15, Fructus Caricae 7-13, Radix Oxyriae sinensis 6-14, Cortex Magnoliae Officinalis 9-13, Cicerbita cyanea (D. Don) beauverd 7-15, Herba Catharanthi Rosei 9-14, Ramulus et Folium visci ovalifolii 8-13, Radix grewiae bilobae 7-12, Cordyceps 10-15.
For curing the preparation of ovarian cancer, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Herba Agrimoniae 12-14, Radix Tylophorae arenicolae 9-12, Rhizoma Belamcandae 8-11, Radix Fici beecheyanae 10-13, Rhizoma Panacis bipinnatifidi 8-14, Radix Actinidiae Erianthae root 11-13, Fructus Caricae 9-12, Radix Oxyriae sinensis 9-12, Cortex Magnoliae Officinalis 10-12, Cicerbita cyanea (D. Don) beauverd 9-13, Herba Catharanthi Rosei 11-13, Ramulus et Folium visci ovalifolii 9-12, Radix grewiae bilobae 8-11, Cordyceps 11-13.
For curing the preparation of ovarian cancer, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Herba Agrimoniae 13, Radix Tylophorae arenicolae 11, Rhizoma Belamcandae 10, Radix Fici beecheyanae 12, Rhizoma Panacis bipinnatifidi 12, Radix Actinidiae Erianthae root 12, Fructus Caricae 11, Radix Oxyriae sinensis 11, Cortex Magnoliae Officinalis 11, Cicerbita cyanea (D. Don) beauverd 11, Herba Catharanthi Rosei 12, Ramulus et Folium visci ovalifolii 11, Radix grewiae bilobae 10, Cordyceps 12.
Present invention also offers the preparation method preparation of aforementioned treatment ovarian cancer being made pharmaceutically acceptable powder, pill, capsule and tablet.
The preparation method of described powder is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.2-1.6 times (amount of preferred rice water is 1.4 times of Rhizoma Belamcandae weight) of Rhizoma Belamcandae weight, stirs, and places 5-9 hour (preferably placing 7 hours), steam 2-3.2 hour (preferably steaming 2.5 hours), put into 65 DEG C of vacuum drying ovens dry 24 hours, be ground into fine powder, cross No. seven sieves;
(2) Fructus Caricae is cleaned, put into pot, decoct with water twice, amount of water is the 4.6-5.8 of Fructus Caricae weight doubly (preferred amount of water is 5.2 times of Fructus Caricae weight), and each decoction 1.5 hours, merges twice filtrate, be condensed into the ointment (being preferably condensed into the ointment that relative density is 1.35) that relative density is 1.33-1.37,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. seven sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. seven sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. seven sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, with 5g often bag subpackage, sterile packaged and get final product.
The preparation method of described pill is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.2-1.6 times (amount of preferred rice water is 1.4 times of Rhizoma Belamcandae weight) of Rhizoma Belamcandae weight, stirs, and places 5-9 hour (preferably placing 7 hours), steam 2-3.2 hour (preferably steaming 2.5 hours), put into 65 DEG C of vacuum drying ovens dry 24 hours, be ground into fine powder, cross No. five sieves;
(2) Fructus Caricae is cleaned, put into pot, decoct with water twice, amount of water is the 4.6-5.8 of Fructus Caricae weight doubly (preferred amount of water is 5.2 times of Fructus Caricae weight), and each decoction 1.5 hours, merges twice filtrate, be condensed into the ointment (being preferably condensed into the ointment that relative density is 1.35) that relative density is 1.33-1.37,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. five sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. five sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. five sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, with water pill, make the pill that particle diameter is 4mm, dry, to obtain final product.
The preparation method of described capsule is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.2-1.6 times (amount of preferred rice water is 1.4 times of Rhizoma Belamcandae weight) of Rhizoma Belamcandae weight, stirs, and places 5-9 hour (preferably placing 7 hours), steam 2-3.2 hour (preferably steaming 2.5 hours), put into 65 DEG C of vacuum drying ovens dry 24 hours, be ground into fine powder, cross No. five sieves;
(2) Fructus Caricae is cleaned, put into pot, decoct with water twice, amount of water is the 4.6-5.8 of Fructus Caricae weight doubly (preferred amount of water is 5.2 times of Fructus Caricae weight), and each decoction 1.5 hours, merges twice filtrate, be condensed into the ointment (being preferably condensed into the ointment that relative density is 1.35) that relative density is 1.33-1.37,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. five sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. five sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. five sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, in incapsulating, medicated powder 0.35g is housed in every capsules, obtains final product.
The preparation method of described tablet is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.2-1.6 times (amount of preferred rice water is 1.4 times of Rhizoma Belamcandae weight) of Rhizoma Belamcandae weight, stirs, and places 5-9 hour (preferably placing 7 hours), steam 2-3.2 hour (preferably steaming 2.5 hours), put into 65 DEG C of vacuum drying ovens dry 24 hours, be ground into fine powder, cross No. five sieves;
(2) Fructus Caricae is cleaned, put into pot, decoct with water twice, amount of water is the 4.6-5.8 of Fructus Caricae weight doubly (preferred amount of water is 5.2 times of Fructus Caricae weight), and each decoction 1.5 hours, merges twice filtrate, be condensed into the ointment (being preferably condensed into the ointment that relative density is 1.35) that relative density is 1.33-1.37,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. five sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. five sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. five sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, be pressed into the tablet of the heavy 0.6g of every sheet, obtain final product.
Preparation recipe science for curing ovarian cancer provided by the invention, takes safely, has no side effect.In addition, excellent results of the present invention also shows:
1, evident in efficacy, not easily recur, to ovary fanout free region;
2, there is effect of blood circulation promoting and blood stasis dispelling, detoxicating and fighting cancer, expelling wind and removing dampness, the kidney invigorating and essence nourishing, replenishing QI to invigorate the spleen, clearing away heat-damp and promoting diuresis, promoting blood circulation and stopping pain, the immunocompetence of patient can be improved, cancer inhibitting and killing cell, make tumor reduce disappearance gradually, prevent its diffusion and transfer;
3, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1for curing the preparation of ovarian cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 430g): Herba Agrimoniae 9 parts, Radix Tylophorae arenicolae 7 parts, Rhizoma Belamcandae 6 parts, Radix Fici beecheyanae 8 parts, Rhizoma Panacis bipinnatifidi 6 parts, Radix Actinidiae Erianthae root 9 parts, Fructus Caricae 7 parts, Radix Oxyriae sinensis 6 parts, Cortex Magnoliae Officinalis 9 parts, Cicerbita cyanea (D. Don) beauverd 7 parts, Herba Catharanthi Rosei 9 parts, Ramulus et Folium visci ovalifolii 8 parts, Radix grewiae bilobae 7 parts, Cordyceps 10 parts.
The preparation method of the above-mentioned preparation powder for curing ovarian cancer is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.2 times of Rhizoma Belamcandae weight, stirs, and places 5 hours, steams 2 hours, puts into 65 DEG C of vacuum drying ovens dry 24 hours, is ground into fine powder, cross No. seven sieves;
(2) cleaned by Fructus Caricae, put into pot, decoct with water twice, amount of water is 4.6 times of Fructus Caricae weight, each decoction 1.5 hours, merges twice filtrate, is condensed into the ointment that relative density is 1.33,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. seven sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. seven sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. seven sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, with 5g often bag subpackage, sterile packaged and get final product.
Gained of the present invention for curing the instructions of taking of the preparation powder of ovarian cancer is: oral, one day twice, each 5g, boiled water was taken after mixing it with water.
embodiment 2for curing the preparation of ovarian cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 430g): Herba Agrimoniae 16 parts, Radix Tylophorae arenicolae 14 parts, Rhizoma Belamcandae 12 parts, Radix Fici beecheyanae 15 parts, Rhizoma Panacis bipinnatifidi 16 parts, Radix Actinidiae Erianthae root 15 parts, Fructus Caricae 13 parts, Radix Oxyriae sinensis 14 parts, Cortex Magnoliae Officinalis 13 parts, Cicerbita cyanea (D. Don) beauverd 15 parts, Herba Catharanthi Rosei 14 parts, Ramulus et Folium visci ovalifolii 13 parts, Radix grewiae bilobae 12 parts, Cordyceps 15 parts.
The preparation method of the above-mentioned preparation pill for curing ovarian cancer is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.4 times of Rhizoma Belamcandae weight, stirs, and places 7 hours, steams 2.5 hours, puts into 65 DEG C of vacuum drying ovens dry 24 hours, is ground into fine powder, cross No. five sieves;
(2) cleaned by Fructus Caricae, put into pot, decoct with water twice, amount of water is 5.2 times of Fructus Caricae weight, each decoction 1.5 hours, merges twice filtrate, is condensed into the ointment that relative density is 1.35,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. five sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. five sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. five sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, with water pill, make the pill that particle diameter is 4mm, dry, to obtain final product.
model case one:week XX, female, 39 years old.Main suit: suffer from ovarian cancer more than 2 years.Before 2 years, during health check-up, patient finds and suffers from ovarian cancer, carries out operative treatment, postoperative chemotherapy at local hospital, and repeatedly, patient occurs that ablative suppresses to chemotherapy, is reluctant to carry out chemotherapy again.Took multi-medicament, and all failed to take a turn for the better.Under the introduction of friend, come here and go to a doctor.Examine and see that patient's abdominal distention is suffered from abdominal pain, emaciated physique, face dolorosa, spiritlessness and weakness, pale complexion, anorexia, the few tongue of red tongue, stringy pulse.Take the present embodiment gained for curing the preparation pill of ovarian cancer, three times on the one, each 4 balls, warm water takes.Take two months, abdominal distention stomachache obviously alleviates.Continue to take two months, all diseases disappear, and check to hospital, and indices is normal, have no focus transfer.Follow up a case by regular visits to and do not recur so far.
embodiment 3for curing the preparation of ovarian cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 430g): Herba Agrimoniae 12 parts, Radix Tylophorae arenicolae 9 parts, Rhizoma Belamcandae 8 parts, Radix Fici beecheyanae 10 parts, Rhizoma Panacis bipinnatifidi 8 parts, Radix Actinidiae Erianthae root 11 parts, Fructus Caricae 9 parts, Radix Oxyriae sinensis 9 parts, Cortex Magnoliae Officinalis 10 parts, Cicerbita cyanea (D. Don) beauverd 9 parts, Herba Catharanthi Rosei 11 parts, Ramulus et Folium visci ovalifolii 9 parts, Radix grewiae bilobae 8 parts, Cordyceps 11 parts.
The preparation method of the above-mentioned preparation capsule for curing ovarian cancer is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.4 times of Rhizoma Belamcandae weight, stirs, and places 7 hours, steams 2.5 hours, puts into 65 DEG C of vacuum drying ovens dry 24 hours, is ground into fine powder, cross No. five sieves;
(2) cleaned by Fructus Caricae, put into pot, decoct with water twice, amount of water is 5.2 times of Fructus Caricae weight, each decoction 1.5 hours, merges twice filtrate, is condensed into the ointment that relative density is 1.35,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. five sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. five sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. five sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, in incapsulating, medicated powder 0.35g is housed in every capsules, obtains final product.
model case two:zhao XX, female, 40 years old.Main suit: suffer from ovarian cancer more than 1 year.Before 1 year, patient finds suffers from ovarian cancer.Through four chemotherapy, there is serious side reaction in patient, and worse and worse, tumor does not only reduce the health of patient, continues on the contrary to increase, and through CT examination, abdomen tumor of pelvic cavity area is 14cm × 16cm.Then my institute requires to carry out Chinese traditional treatment.Examine and see that patient mental is dispirited, hard, the fixing lump of abdominal part, lower abdomen pain, complexion is dark dim, emaciated physique, spiritlessness and weakness, and stomach poor appetite is few, and dimly purple tongue has ecchymosis, thready pulse.Take the present embodiment gained for curing the preparation capsule of ovarian cancer, three times on the one, each 4 balls, warm water takes.Take two months, abdominal mass obviously reduces, and lower abdomen pain disappears.Continue to take two months, abdominal mass disappears, and all diseases disappear, and check to hospital, and indices is normal, has no focus transfer.Follow up a case by regular visits to and do not recur so far.
embodiment 4for curing the preparation of ovarian cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 430g): Herba Agrimoniae 14 parts, Radix Tylophorae arenicolae 12 parts, Rhizoma Belamcandae 11 parts, Radix Fici beecheyanae 13 parts, Rhizoma Panacis bipinnatifidi 14 parts, Radix Actinidiae Erianthae root 13 parts, Fructus Caricae 12 parts, Radix Oxyriae sinensis 12 parts, Cortex Magnoliae Officinalis 12 parts, Cicerbita cyanea (D. Don) beauverd 13 parts, Herba Catharanthi Rosei 13 parts, Ramulus et Folium visci ovalifolii 12 parts, Radix grewiae bilobae 11 parts, Cordyceps 13 parts.
The preparation method of the above-mentioned formulation tablet for curing ovarian cancer is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.4 times of Rhizoma Belamcandae weight, stirs, and places 7 hours, steams 2.5 hours, puts into 65 DEG C of vacuum drying ovens dry 24 hours, is ground into fine powder, cross No. five sieves;
(2) cleaned by Fructus Caricae, put into pot, decoct with water twice, amount of water is 5.2 times of Fructus Caricae weight, each decoction 1.5 hours, merges twice filtrate, is condensed into the ointment that relative density is 1.35,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. five sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. five sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. five sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, be pressed into the tablet of the heavy 0.6g of every sheet, obtain final product.
model case three:liu XX, female, 52 years old.Main suit: suffer from more than ovarian cancer August.Before eight months, there is abdominal distention in patient, with poor appetite, spiritlessness and weakness.Ovarian cancer is diagnosed as to local hospital inspection.Adopt the method treatment of operation and postoperative chemotherapy.Because leukopenia has appearred obvious side effect, in patient after chemotherapy, physical weakness and stopped chemotherapy.Then come my institute and ask Chinese traditional treatment.Examine and see patient's abdominal mass, abdominal distention, poor appetite, spiritlessness and weakness, lean body mass, body of the tongue is dim red, yellowish fur, rolling pulse.Take the present embodiment gained for curing the formulation tablet of ovarian cancer, three times on the one, each 2, warm water takes.Take two months, abdominal mass obviously reduces.Continue to take two months, all diseases disappear, and check to hospital, and indices is normal, have no focus transfer.Follow up a case by regular visits to and do not recur so far.
embodiment 5for curing the preparation of ovarian cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 430g): Herba Agrimoniae 13 parts, Radix Tylophorae arenicolae 11 parts, Rhizoma Belamcandae 10 parts, Radix Fici beecheyanae 12 parts, Rhizoma Panacis bipinnatifidi 12 parts, Radix Actinidiae Erianthae root 12 parts, Fructus Caricae 11 parts, Radix Oxyriae sinensis 11 parts, Cortex Magnoliae Officinalis 11 parts, Cicerbita cyanea (D. Don) beauverd 11 parts, Herba Catharanthi Rosei 12 parts, Ramulus et Folium visci ovalifolii 11 parts, Radix grewiae bilobae 10 parts, Cordyceps 12 parts.
The preparation method of the above-mentioned preparation powder for curing ovarian cancer is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.4 times of Rhizoma Belamcandae weight, stirs, and places 7 hours, steams 2.5 hours, puts into 65 DEG C of vacuum drying ovens dry 24 hours, is ground into fine powder, cross No. seven sieves;
(2) cleaned by Fructus Caricae, put into pot, decoct with water twice, amount of water is 5.2 times of Fructus Caricae weight, each decoction 1.5 hours, merges twice filtrate, is condensed into the ointment that relative density is 1.35,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. seven sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. seven sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. seven sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, with 5g often bag subpackage, sterile packaged and get final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Agrimoniae: base is former: be the herb of rosaceous plant Agrimony.Chemical analysis: herb is containing agrimonine, agrimonolide, tannin (for Jiao's property catechol tannin, gallotannin etc.), sterol, organic acid, phenolic constituent, Saponin etc.Root is containing tannin 8.9%, and stem is containing tannin 6.5%, and leaf is containing tannin 16.4%.Stem, leaf are also containing luteolin-7-β-glycoside and apigenin-7-β-glycoside.The property of medicine: bitter, pungent, flat.Return lung, liver, spleen channel.Function cures mainly: hemostasis, stomach invigorating.Control spitting of blood, spit blood, hematuria, has blood in stool, dysentery, bleeding not during menses, and impairment caused by overstrain takes off power, carbuncle, traumatic injury, wound hemorrhage.
Radix Tylophorae arenicolae: base is former: the root disappeared for the spirit of asclepiadaceae plant bamboo or aerial parts.The property of medicine: bitter in the mouth; Micro-pungent; Property is put down.Return lung meridian.Function cures mainly: clearing away heat and cooling blood; Function of gallbladder promoting; Removing toxic substances.Main fever due to yin deficiency; Asthenia chronic cough; Spitting of blood; Distending pain over the hypochondrium; Vomiting and nausea; Dysentery; Puerperal fidgets due to deficiency; Scrofula; Innominate toxic swelling; Serpentis worm; Mad dog is bitten.
Rhizoma Belamcandae: base is former: be the rhizome of irides Rhizoma Belamcandae.Chemical analysis: rhizome is containing belamcandin, tectoridin, shekanin, tectorigenin.Flower, leaf are containing Mengiferin.The property of medicine: bitter, cold.Return lung meridian.Function cures mainly: heat-clearing and toxic substances removing, expectorant, sore-throat relieving.For the pent-up of pyretic toxicity phlegm-fire, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.
Radix Fici beecheyanae: base is former: be the root of moraceae plants Fructus Fici Beecheyanae.The property of medicine: sweet; Pungent; Warm in nature.Return lung, spleen, kidney channel.Function cures mainly: replenishing QI to invigorate the spleen, promoting blood circulation to remove obstruction in the collateral, expelling wind and removing dampness.Main overstrain is weak, lack of appetite, agalactia, insufficiency of the spleen leucorrhea, proctoptosis, menoxenia, wind syndrome of head pain, traumatic injury, rheumatic arthralgia.
Rhizoma Panacis bipinnatifidi: base is former: be the rhizome of Araliaceae leatherleaf Rhizoma Panacis Japonici.The property of medicine: mildly bitter flavor; Bitter; Slightly warm in nature.Function cures mainly: removing stasis to stop bleeding; Subduing swelling and relieving pain.Main spitting of blood; Spit blood; Epistaxis; Hematuria; Have blood in stool; Dysentery; Metrorrhagia; Traumatic hemorrhage; Menoxenia; Amenorrhea; Postnatal blood stasis is suffered from abdominal pain; Treating swelling and pain by traumatic injury; Impairment caused by overstrain lumbago; Chest and hypochondrium; Gastric abscess; Skin infection.
Radix Actinidiae Erianthae root: base is former: be root and the root bark of Actinidiaceae plant actinidia eriantha.The property of medicine: light; Micro-pungent; Cold.Function cures mainly: removing toxic substances and promoting subsidence of swelling; Clearing away heat-damp and promoting diuresis.Main pyretic toxicity carbuncle; Acute mastitis; Lung-heat aphonia; Hygropyretic dysentery; Stranguria with turbid discharge; Leukorrhagia; Rheumatic arthralgia; Gastric cancer; The esophageal carcinoma; Breast carcinoma; Traumatic injury.
Fructus Caricae: base is former: be the fruit of Caricaceae plant Fructus Caricae.The property of medicine: sweet in the mouth; Property is put down.Function cures mainly: help digestion stimulating milk secretion; Eliminating dampness and dredging channels; Removing toxic substances anthelmintic.Main dyspepsia; Stomach; Duodenal ulcer pain; Milk is rare; Rheumatic arthralgia; Numb limbs and tense tendons; Eczema; Rotten skin ulcer; Intestinal parasitical diseases.
Radix Oxyriae sinensis: base is former: be the root of Huashan knotweed in polygonaceae plant.The property of medicine: sweet; Puckery; Property is put down.Return liver, spleen channel.Function cures mainly: relaxing muscles and tendons and activating QI and blood in the collateral; Promoting blood circulation and stopping pain; Astringent therapy dysentery relieving.Main traumatic injury; Lumbago and skelalgia; Dysentery; De-gallbladder.
Cortex Magnoliae Officinalis: base is former: be the bark of Magnoliacea plant Cortex Magnoliae Officinalis and Mount Lushan Cortex Magnoliae Officinalis, root bark and branch skin.The property of medicine: bitter, pungent, temperature.Return spleen, stomach, large intestine channel.Function cures mainly: circulation of qi promoting removing food stagnancy, dampness are except full, lowering the adverse QI to relieve asthma.For stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, expectorant stops up QI rising in reverse order, fullness in the chest is breathed with cough.
Cicerbita cyanea (D. Don) beauverd: base is former: be the root of feverfew Cicerbita cyanea (D. Don) beauverd.The property of medicine: bitter in the mouth; Property is put down.Function cures mainly: invigorating the spleen and regulating the stomach.Main gastritis; Stomach; Duodenal ulcer; Inappetence.
Herba Catharanthi Rosei: base is former: be Apocynaceae periwinkle plant Herba Catharanthi Rosei, the herb of yellow Herba Catharanthi Rosei.Composition: plant containing indoles alkaloid more than 70 in Herba Catharanthi Rosei, comprise vinblastine, vincristine, lochnericine, lochnericine, remove acetyl vindorosine, vincaleucoblastine, Changchun Buddhist nun is fixed, lochnerinine etc.Root containing alkaloid, comprises that 9-methoxycorynantheidine., akuammicine, west, Changchun are fixed, lochnerivine, cavineine sulfate, sulphuric acid stay around western language alkali, and ammocalline, sulphuric acid group is around raw etc.Pharmacology: 1. antitumor action.The vinblastine that Herba Catharanthi Rosei contains, vincristine, leurosine, leurosidine have obvious antitumor action.2. Antitumor Mechanism.Herba Catharanthi Rosei antitumor action is directly relevant to the high-affinity of tubulin binding with medicine, suppress nucleic acid synthesis be it another mechanism.3. blood pressure lowering and vasodilative effect.No matter catharanthus roseus total alkaloids gavage, intramuscular injection or quiet note all have hypotensive effect to anesthetized dog, also has the effect of expansion coronary vasodilator.4. blood sugar lowering and effect for reducing blood fat.The water extract of this product leaf has normal or alloxan diabetes rabbit and dog and reduces blood glucose effect.The property of medicine: bitter, cold, poisonous.Function cures mainly: detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver.Cure mainly multiple cancerous protuberance, hypertension, carbuncle sore tumefacting virus, scald.
Ramulus et Folium visci ovalifolii: base is former: be the base of leaf branch of Loranthaceae plant Viscum avalifolium.The property of medicine: bitter; Pungent; Cool in nature.Return liver, lung meridian.Function cures mainly: expelling wind and removing dampness; Promoting blood circulation and stopping pain; Preventing phlegm from forming and stopping coughing; Removing toxic substances.Main air pain of dampness syndrome; Swelling of the feet; Traumatic injury; Colicky; Toothache; Infantile malnutrition; Dysentery; Cough; Fiber crops wound; Rheumatic arthralgia.Dysentery can be controlled again; Infantile malnutrition.
Radix grewiae bilobae: base is former: be the Herb of Tiliaceae plant bilobed grewia.The property of medicine: sweet; Bitter; Temperature.Return liver, spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI; Expelling wind and removing dampness; Treating spontaneous emission and leukorrhagia.Main insufficiency of the spleen lack of appetite; Proctoptosis of a specified duration; Infantile malnutrition; Ascariasis; Rheumatic arthralgia; Seminal emission; Metrorrhagia; Leukorrhagia; Uterine prolapse.
Cordyceps: base is former: be the complex of the larva body (sclerotium) of the Stroma and host's Hepialidae insecticide Hepialus etc. thereof of section ergot fungus cordyceps sinensis bacterium.The property of medicine: sweet; Temperature; Fragrant.Return lung, kidney channel.Function cures mainly: protect lung qi, real space between skin and muscles, the kidney invigorating and essence nourishing.Main cough and asthma due to lung deficiency, chronic cough expectorant blood, spontaneous perspiration, night sweat, deficiency of the kidney sexual impotence, seminal emission, soreness of waist and knee joint.
test example 1gained of the present invention is for curing the clinical practice of the preparation (embodiment 5) of ovarian cancer: in January, 2009 in December ,-2010, screen 280 routine ovarian cancer patients in 5 hospitals and carry out clinical observation, patient is women, is all diagnosed as ovarian cancer through cytology and pathology section.Be divided into two groups at random, experimental group and matched group (often organizing 140 people).Two groups of patients compare in the physical data such as age, the state of an illness, and there was no significant difference, has comparability.Experimental group uses gained of the present invention for curing the preparation of ovarian cancer, using method: twice on the one, a 5g, and boiled water is taken after mixing it with water, and within 1 month, is a course for the treatment of.Matched group adopts operative treatment, postoperative chemotherapy.
Curative effect situation criterion: complete incidence graph (CR): cases of complete remission, maintains more than 4 weeks; Partial rcsponse (PR): tumor regression more than 50%, and maintain more than 4 weeks; Stable disease (SD): tumor regression < 50%, or tumor increases < 25%, and maintain more than 4 weeks; Disease progression (PD): tumor increases > 25% or occurs new pathological changes.Always effectively comprise complete incidence graph and partial rcsponse.Treat after four months, result is as shown in table 1.
Table 1: gained of the present invention is for curing the preparation compliance test result [example (%)] of ovarian cancer
Therapeutic effect: in 140 routine patients of experimental group, complete incidence graph 72 example, accounts for 51.43%; Partial rcsponse 64 example, accounts for 45.71%; Stable disease 2 example, accounts for 1.43%; Disease progression 2 example, accounts for 1.43%; Total effective rate reaches 97.14%.In 140 routine patients of matched group, complete incidence graph 28 example, accounts for 20%; Partial rcsponse 74 example, accounts for 52.86%; Stable disease 24 example, accounts for 17.14%; Disease progression 14 example, accounts for 10%; Total effective rate is 72.86%.Experimental group total effective rate is obviously better than matched group, and two groups of comparing differences have significance.
The present invention is primary raw material medicine with Herba Agrimoniae, Radix Tylophorae arenicolae, Rhizoma Belamcandae and Radix Fici beecheyanae etc., makes the preparation for curing ovarian cancer.Herba Agrimoniae hemostasis in side, stomach invigorating.Radix Tylophorae arenicolae clearing away heat and cooling blood; Function of gallbladder promoting; Removing toxic substances.Rhizoma Belamcandae heat-clearing and toxic substances removing, expectorant, sore-throat relieving.Radix Fici beecheyanae replenishing QI to invigorate the spleen, promoting blood circulation to remove obstruction in the collateral, expelling wind and removing dampness.Rhizoma Panacis bipinnatifidi removing stasis to stop bleeding; Subduing swelling and relieving pain.Radix Actinidiae Erianthae root removing toxic substances and promoting subsidence of swelling; Clearing away heat-damp and promoting diuresis.Fructus Caricae helps digestion stimulating milk secretion; Eliminating dampness and dredging channels; Removing toxic substances anthelmintic.Radix Oxyriae sinensis relaxing muscles and tendons and activating QI and blood in the collateral; Promoting blood circulation and stopping pain; Astringent therapy dysentery relieving.Cortex Magnoliae Officinalis circulation of qi promoting removing food stagnancy, dampness are except full, lowering the adverse QI to relieve asthma.Cicerbita cyanea (D. Don) beauverd invigorating the spleen and regulating the stomach.Herba Catharanthi Rosei detoxicating and fighting cancer, heat clearing away suppressing the hyperactive liver.Ramulus et Folium visci ovalifolii expelling wind and removing dampness; Promoting blood circulation and stopping pain; Preventing phlegm from forming and stopping coughing; Removing toxic substances.Radix grewiae bilobae invigorating the spleen and benefiting QI; Expelling wind and removing dampness; Treating spontaneous emission and leukorrhagia.Lung qi protected by Cordyceps, real space between skin and muscles, the kidney invigorating and essence nourishing.All medicines share, and play the effect of blood circulation promoting and blood stasis dispelling, detoxicating and fighting cancer, expelling wind and removing dampness, the kidney invigorating and essence nourishing, replenishing QI to invigorate the spleen, clearing away heat-damp and promoting diuresis, promoting blood circulation and stopping pain altogether, can improve the immunocompetence of patient, and cancer inhibitting and killing cell makes tumor reduce disappearance gradually, prevent its diffusion and transfer.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. for curing the preparation of ovarian cancer, it is characterized in that, taking off the primary raw material medicine stating weight proportion and being prepared from: Herba Agrimoniae 9-16, Radix Tylophorae arenicolae 7-14, Rhizoma Belamcandae 6-12, Radix Fici beecheyanae 8-15, Rhizoma Panacis bipinnatifidi 6-16, Radix Actinidiae Erianthae root 9-15, Fructus Caricae 7-13, Radix Oxyriae sinensis 6-14, Cortex Magnoliae Officinalis 9-13, Cicerbita cyanea (D. Don) beauverd 7-15, Herba Catharanthi Rosei 9-14, Ramulus et Folium visci ovalifolii 8-13, Radix grewiae bilobae 7-12, Cordyceps 10-15.
2. as claimed in claim 1 for curing the preparation of ovarian cancer, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Herba Agrimoniae 12-14, Radix Tylophorae arenicolae 9-12, Rhizoma Belamcandae 8-11, Radix Fici beecheyanae 10-13, Rhizoma Panacis bipinnatifidi 8-14, Radix Actinidiae Erianthae root 11-13, Fructus Caricae 9-12, Radix Oxyriae sinensis 9-12, Cortex Magnoliae Officinalis 10-12, Cicerbita cyanea (D. Don) beauverd 9-13, Herba Catharanthi Rosei 11-13, Ramulus et Folium visci ovalifolii 9-12, Radix grewiae bilobae 8-11, Cordyceps 11-13.
3. as claimed in claim 1 for curing the preparation of ovarian cancer, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Herba Agrimoniae 13, Radix Tylophorae arenicolae 11, Rhizoma Belamcandae 10, Radix Fici beecheyanae 12, Rhizoma Panacis bipinnatifidi 12, Radix Actinidiae Erianthae root 12, Fructus Caricae 11, Radix Oxyriae sinensis 11, Cortex Magnoliae Officinalis 11, Cicerbita cyanea (D. Don) beauverd 11, Herba Catharanthi Rosei 12, Ramulus et Folium visci ovalifolii 11, Radix grewiae bilobae 10, Cordyceps 12.
4. the preparation for curing ovarian cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment ovarian cancer is made pharmaceutically acceptable powder, and the preparation method of described powder is:
(1) Rhizoma Belamcandae is ground into coarse powder, crosses 30 mesh sieves, add rice water, the amount of rice water is 1.2-1.6 times of Rhizoma Belamcandae weight, stirs, and places 5-9 hour, steams 2-3.2 hour, puts into 65 DEG C of vacuum drying ovens dry 24 hours, is ground into fine powder, cross No. seven sieves;
(2) Fructus Caricae is cleaned, put into pot, decoct with water twice, amount of water is the 4.6-5.8 of Fructus Caricae weight doubly (preferred amount of water is 5.2 times of Fructus Caricae weight), and each decoction 1.5 hours, merges twice filtrate, be condensed into the ointment (being preferably condensed into the ointment that relative density is 1.35) that relative density is 1.33-1.37,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. seven sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. seven sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. seven sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, with 5g often bag subpackage, sterile packaged and get final product.
5. the preparation for curing ovarian cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment ovarian cancer is made pharmaceutically acceptable pill, and the preparation method of described pill is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.2-1.6 times (amount of preferred rice water is 1.4 times of Rhizoma Belamcandae weight) of Rhizoma Belamcandae weight, stirs, and places 5-9 hour (preferably placing 7 hours), steam 2-3.2 hour (preferably steaming 2.5 hours), put into 65 DEG C of vacuum drying ovens dry 24 hours, be ground into fine powder, cross No. five sieves;
(2) Fructus Caricae is cleaned, put into pot, decoct with water twice, amount of water is the 4.6-5.8 of Fructus Caricae weight doubly (preferred amount of water is 5.2 times of Fructus Caricae weight), and each decoction 1.5 hours, merges twice filtrate, be condensed into the ointment (being preferably condensed into the ointment that relative density is 1.35) that relative density is 1.33-1.37,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. five sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. five sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. five sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, with water pill, make the pill that particle diameter is 4mm, dry, to obtain final product.
6. the preparation for curing ovarian cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment ovarian cancer is made pharmaceutically acceptable capsule, and the preparation method of described capsule is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.2-1.6 times (amount of preferred rice water is 1.4 times of Rhizoma Belamcandae weight) of Rhizoma Belamcandae weight, stirs, and places 5-9 hour (preferably placing 7 hours), steam 2-3.2 hour (preferably steaming 2.5 hours), put into 65 DEG C of vacuum drying ovens dry 24 hours, be ground into fine powder, cross No. five sieves;
(2) Fructus Caricae is cleaned, put into pot, decoct with water twice, amount of water is the 4.6-5.8 of Fructus Caricae weight doubly (preferred amount of water is 5.2 times of Fructus Caricae weight), and each decoction 1.5 hours, merges twice filtrate, be condensed into the ointment (being preferably condensed into the ointment that relative density is 1.35) that relative density is 1.33-1.37,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. five sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. five sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. five sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, in incapsulating, medicated powder 0.35g is housed in every capsules, obtains final product.
7. the preparation for curing ovarian cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment ovarian cancer is made pharmaceutically acceptable tablet, and the preparation method of described tablet is:
(1) Rhizoma Belamcandae is ground into coarse powder, cross 30 mesh sieves, add rice water, the amount of rice water is 1.2-1.6 times (amount of preferred rice water is 1.4 times of Rhizoma Belamcandae weight) of Rhizoma Belamcandae weight, stirs, and places 5-9 hour (preferably placing 7 hours), steam 2-3.2 hour (preferably steaming 2.5 hours), put into 65 DEG C of vacuum drying ovens dry 24 hours, be ground into fine powder, cross No. five sieves;
(2) Fructus Caricae is cleaned, put into pot, decoct with water twice, amount of water is the 4.6-5.8 of Fructus Caricae weight doubly (preferred amount of water is 5.2 times of Fructus Caricae weight), and each decoction 1.5 hours, merges twice filtrate, be condensed into the ointment (being preferably condensed into the ointment that relative density is 1.35) that relative density is 1.33-1.37,60 DEG C of dryings 14 hours, are ground into fine powder, cross No. five sieves;
(3) Cordyceps is dried in the shade, be ground into fine powder, cross No. five sieves;
(4) by all the other the 11 taste crude drug mixing except Rhizoma Belamcandae, Fructus Caricae and Cordyceps, put into 60 DEG C of vacuum drying ovens dry 12 hours, take out, be ground into fine powder, cross No. five sieves;
(5) step (1), step (2), step (3) and step (4) gained are mixed, be pressed into the tablet of the heavy 0.6g of every sheet, obtain final product.
8. as claimed in claim 4 for curing the preparation method of the preparation powder of ovarian cancer, it is characterized in that, in step (1), the amount of rice water is 1.4 times of Rhizoma Belamcandae weight.
9. as claimed in claim 4 for curing the preparation method of the preparation powder of ovarian cancer, it is characterized in that, placing 7 hours in step (1).
10. as claimed in claim 4 for curing the preparation method of the preparation powder of ovarian cancer, it is characterized in that, steaming 2.5 hours in step (1).
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| CN101530508A (en) * | 2008-03-13 | 2009-09-16 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating ovarian cancer |
| CN104147534A (en) * | 2014-08-26 | 2014-11-19 | 张五星 | Traditional Chinese medicine composition for treating various cancers |
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| CN101530508A (en) * | 2008-03-13 | 2009-09-16 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating ovarian cancer |
| CN104147534A (en) * | 2014-08-26 | 2014-11-19 | 张五星 | Traditional Chinese medicine composition for treating various cancers |
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Application publication date: 20151202 |