CN105106154A - Sugar-free calcium tablets for middle-aged and aged people and preparation method thereof - Google Patents
Sugar-free calcium tablets for middle-aged and aged people and preparation method thereof Download PDFInfo
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- CN105106154A CN105106154A CN201510589790.6A CN201510589790A CN105106154A CN 105106154 A CN105106154 A CN 105106154A CN 201510589790 A CN201510589790 A CN 201510589790A CN 105106154 A CN105106154 A CN 105106154A
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Abstract
The invention belongs to the field of calcium tablet preparation, and particularly relates to sugar-free calcium tablets for middle-aged and aged people and a preparation method thereof. The calcium tablets are prepared from, by weight, 1160-1220 parts of calcium carbonate, 345-365 parts of sorbitol, 25 parts of citric acid, 5 parts of purified water, 8.5 parts of edible alcohol, 635-647 parts of dextrin, 240-250 parts of maltodextrin, 3-4 parts of sweet orange essence, 0.5-1.0 part of sucralose and 23-27 parts of magnesium stearate. The non-sugar sweetening agents are adopted for increasing the sweetness of the calcium tablets without increasing calories, and the prepared sugar-free calcium tablets have the advantages of having low calories, achieving low-temperature oxidation resistance, and being free of sugar and easy to absorb.
Description
Technical field
The invention belongs to the preparation field of calcium tablet, be specifically related to a kind of person in middle and old age without TANGGAI PIAN and preparation method thereof.
Background technology
The meals composition of China is based on plant food, and calcium content is few, and the abundant food of calcium content is few, and calcium phosphorus ratio is seriously inverted, and is unfavorable for absorbing of calcium, has that phytic acid content is high etc. is multiplely unfavorable for the factor that calcium absorption utilizes in meals simultaneously.At present, one of most effective measures improving crowd calcium intake are exactly strengthen calcium in food.Though the food of numerous commercial ca preparation and strengthening calcium is had existing, most ofs expensive, be difficult to popularization, and the effect of supplemented calcium of most products itself and absorption rate are also required study.The calcium source used in current commercial ca preparation and condensed food mainly contains calcium carbonate, calcium lactate, calcium citrate and calcium gluconate etc., wherein uses maximum calcium carbonate that is still, and because its calcium content is high, the use amount in condensed food is few, have no side effect, inexpensive.
Due to reasons such as food source, dietary habit and diet structures, China's different age people dietary calcium intake is generally lower than meals Middle nutrition element recommended intake (RNIs or AIs) standard every day that Chinese Soclety of Nutrition is recommended, and middle-aged and elderly people calcium deficiency is especially serious.But middle-aged and elderly people much exists, and blood fat is high, blood glucose is high, the phenomenon of hypertension, being applicable to the health promoting product that eats of this crowd must low sugar, low in calories.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, provide a kind of person in middle and old age without TANGGAI PIAN and preparation method thereof.The advantage that this calcium tablet has low in calories, low temperature antioxidation, sugar-free, easily absorbs.
For achieving the above object, the present invention adopts following technical scheme:
A kind of person in middle and old age are without TANGGAI PIAN, its raw material composition is counted by weight, calcium carbonate 1160 ~ 1220 parts, Sorbitol 345 ~ 365 parts, citric acid 25 parts, purified water 5 parts, edible ethanol 8.5 parts, 635 ~ 647 parts, dextrin, maltodextrin 240 ~ 250 parts, orange flavor 3 ~ 4 parts, sucralose 0.5 ~ 1.0 part, magnesium stearate 23 ~ 27 parts.
Described person in middle and old age are without TANGGAI PIAN, and its raw material composition is preferably by weight, calcium carbonate 1200 parts, Sorbitol 357 parts, citric acid 25 parts, purified water 5 parts, edible ethanol 8.5 parts, 643 parts, dextrin, maltodextrin 245.8 parts, orange flavor 3.5 parts, sucralose 0.7 part, magnesium stearate 25 parts.
Person in middle and old age as above, without a preparation method for TANGGAI PIAN, comprise the following steps:
(1) prepare burden: weighed raw material respectively by formula proportion; After load weighted calcium carbonate, dextrin, maltodextrin, sucralose mixing 20min, obtained compound;
(2) solution preparation: citric acid purified water dissolved, adds edible ethanol and is deployed into citric acid solution;
(3) mixing granulation: the compound that step (1) is obtained is placed in efficient wet granulator, adds citric acid solution, by the operation of efficient wet granulator S.O.P., makes 16 object wet granulars;
(4) dry: first open HighefficientFluidbeddrier, more slowly sent in HighefficientFluidbeddrier by wet granular, temperature controls at 65 DEG C, and vapor tension control, at 0.15MPa, is dried to pellet moisture and is down to less than 5%;
(5) granulate: the efficient pelletizing machine of dried granule is passed through 14 mesh sieve granulate;
(6) always mix: the material after granulate is added in two-dimensional motion mixer, add magnesium stearate, orange flavor, Sorbitol, mixing 10min;
(7) tabletting: the hopper that the granule after mixing is placed in rotary tablet machine is carried out tabletting, in tableting processes, every 30min survey sheet is heavy once, controls every sheet at 2.45 ~ 2.50g/ sheet.
beneficial effect of the present invention is:
1) the present invention adopts sorbitol and sucralose to be sweeting agent, makes calcium tablet have the performance such as sugar-free, low heat value; Consider the easy moisture absorption of sorbitol, the present invention increases dextrin consumption, ensure that the drying of product; Not only be applicable to physical labourer but also be applicable to brain worker, the special populations such as diabetics, three-hypers patient are also suitable for; It is the novel product of a kind of low cost, high added value;
2) intake of invented food calcium is 470 ~ 475mg/d, and effect of supplemented calcium is obvious.
Detailed description of the invention
The present invention's the following example further illustrates the present invention, but protection scope of the present invention is not limited to the following example.
embodiment 1
Person in middle and old age are without TANGGAI PIAN, and its raw material consists of, calcium carbonate 1200g, Sorbitol 357g, citric acid 25g, purified water 5g, edible ethanol 8.5g, dextrin 643g, maltodextrin 245.8g, orange flavor 3.5g, sucralose 0.7g, magnesium stearate 25g;
Preparation method, concrete steps are:
(1) prepare burden: weighed raw material respectively by formula proportion; After load weighted calcium carbonate, dextrin, maltodextrin, sucralose mixing 20min, obtained compound;
(2) solution preparation: citric acid purified water dissolved, adds edible ethanol and is deployed into citric acid solution;
(3) mixing granulation: the compound that step (1) is obtained is placed in efficient wet granulator, adds citric acid solution, by the operation of efficient wet granulator S.O.P., makes 16 object wet granulars;
(4) dry: first open HighefficientFluidbeddrier, more slowly sent in HighefficientFluidbeddrier by wet granular, temperature controls at 65 DEG C, and vapor tension control, at 0.15MPa, is dried to pellet moisture and is down to less than 5%;
(5) granulate: the efficient pelletizing machine of dried granule is passed through 14 mesh sieve granulate;
(6) always mix: the material after granulate is added in two-dimensional motion mixer, add magnesium stearate, orange flavor, Sorbitol, mixing 10min;
(7) tabletting: the hopper that the granule after mixing is placed in rotary tablet machine is carried out tabletting, in tableting processes, every 30min survey sheet is heavy once, controls every sheet at 2.45 ~ 2.50g/ sheet, makes 1000;
Middle-aged and elderly people eats a slice (2.50g/ sheet) every day, and the intake of calcium is 470 ~ 475mg/d, and effect of supplemented calcium is obvious.
embodiment 2
Person in middle and old age are without TANGGAI PIAN, and its raw material consists of, calcium carbonate 1181g, Sorbitol 365g, citric acid 25g, purified water 5g, edible ethanol 8.5g, dextrin 647g, maltodextrin 250g, orange flavor 4g, sucralose 1.0g, magnesium stearate 27g;
Preparation method, concrete steps are:
(1) prepare burden: weighed raw material respectively by formula proportion; After load weighted calcium carbonate, dextrin, maltodextrin, sucralose mixing 20min, obtained compound;
(2) solution preparation: citric acid purified water dissolved, adds edible ethanol and is deployed into citric acid solution;
(3) mixing granulation: the compound that step (1) is obtained is placed in efficient wet granulator, adds citric acid solution, by the operation of efficient wet granulator S.O.P., makes 16 object wet granulars;
(4) dry: first open HighefficientFluidbeddrier, more slowly sent in HighefficientFluidbeddrier by wet granular, temperature controls at 65 DEG C, and vapor tension control, at 0.15MPa, is dried to pellet moisture and is down to less than 5%;
(5) granulate: the efficient pelletizing machine of dried granule is passed through 14 mesh sieve granulate;
(6) always mix: the material after granulate is added in two-dimensional motion mixer, add magnesium stearate, orange flavor, Sorbitol, mixing 10min;
(7) tabletting: the hopper that the granule after mixing is placed in rotary tablet machine is carried out tabletting, in tableting processes, every 30min survey sheet is heavy once, controls every sheet at 2.45 ~ 2.50g/ sheet, makes 1000.
embodiment 3
A kind of person in middle and old age are without TANGGAI PIAN, and its raw material composition is counted by weight, calcium carbonate 1220g, Sorbitol 345g, citric acid 25g, purified water 5g, edible ethanol 8.5g, dextrin 635g, maltodextrin 248.5g, orange flavor 3g, sucralose 0.5g, magnesium stearate 23g;
Preparation method, concrete steps are:
(1) prepare burden: weighed raw material respectively by formula proportion; After load weighted calcium carbonate, dextrin, maltodextrin, sucralose mixing 20min, obtained compound;
(2) solution preparation: citric acid purified water dissolved, adds edible ethanol and is deployed into citric acid solution;
(3) mixing granulation: the compound that step (1) is obtained is placed in efficient wet granulator, adds citric acid solution, by the operation of efficient wet granulator S.O.P., makes 16 object wet granulars;
(4) dry: first open HighefficientFluidbeddrier, more slowly sent in HighefficientFluidbeddrier by wet granular, temperature controls at 65 DEG C, and vapor tension control, at 0.15MPa, is dried to pellet moisture and is down to less than 5%;
(5) granulate: the efficient pelletizing machine of dried granule is passed through 14 mesh sieve granulate;
(6) always mix: the material after granulate is added in two-dimensional motion mixer, add magnesium stearate, orange flavor, Sorbitol, mixing 10min;
(7) tabletting: the hopper that the granule after mixing is placed in rotary tablet machine is carried out tabletting, in tableting processes, every 30min survey sheet is heavy once, controls every sheet at 2.45 ~ 2.50g/ sheet, makes 1000.
conditional filtering is tested:
1)the screening experiment result of adjuvant
The screening experiment result of table 1 adjuvant
2)
the adjustment of sour-sweet sense
Citric acid amount can cover the astringent taste of calcium carbonate.At oxide spinel calcium consumption, adjuvant (sweeting agent
,magnesium stearate) in the constant situation of consumption, devise 3 different citric acid amounts, each tested number is undertaken by making 1000 (2.5g/ sheets), examines or check, the results are shown in Table 2 to the mouthfeel of tablet.Result shows, No. 2 test sour and sweet palatabilities, effect is better.
The consumption of table 2 citric acid is on the impact of mouthfeel
3) three batches of scale up test verification msgs
This Product Process is reliable and stable, and the production technology according to trial test carries out enlarged experiment, carries out process certification and bias correction to the production technology drafted.Amplify 12 times with this technique by formula ratio, by 3 batches of scale up test, theoretical yield, actually must to measure, the scale up test technical data such as yield rate, result proves that Product Process is stablized.Concrete condition sees the following form 3.
Table 3 three batches of scale up test verification msgs
* purified water and edible ethanol consumption add according to 12 times of amplifications
4) efficacy assessments
table 4 is grown up invented food Nutrition intake information slip
The foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Claims (3)
1. person in middle and old age are without TANGGAI PIAN, it is characterized in that: its raw material composition is counted by weight, calcium carbonate 1160 ~ 1220 parts, Sorbitol 345 ~ 365 parts, citric acid 25 parts, purified water 5 parts, edible ethanol 8.5 parts, 635 ~ 647 parts, dextrin, maltodextrin 240 ~ 250 parts, orange flavor 3 ~ 4 parts, sucralose 0.5 ~ 1.0 part, magnesium stearate 23 ~ 27 parts.
2. person in middle and old age according to claim 1 are without TANGGAI PIAN, it is characterized in that: its raw material composition is counted by weight, calcium carbonate 1200 parts, Sorbitol 357 parts, citric acid 25 parts, purified water 5 parts, edible ethanol 8.5 parts, 643 parts, dextrin, maltodextrin 245.8 parts, orange flavor 3.5 parts, sucralose 0.7 part, magnesium stearate 25 parts.
3. person in middle and old age as claimed in claim 1 are without a preparation method for TANGGAI PIAN, it is characterized in that: comprise the following steps:
(1) prepare burden: weighed raw material respectively by formula proportion; After load weighted calcium carbonate, dextrin, maltodextrin, sucralose mixing 20min, obtained compound;
(2) solution preparation: citric acid purified water dissolved, adds edible ethanol and is deployed into citric acid solution;
(3) mixing granulation: the compound that step (1) is obtained is placed in efficient wet granulator, adds citric acid solution, by the operation of efficient wet granulator S.O.P., makes 16 object wet granulars;
(4) dry: first open HighefficientFluidbeddrier, more slowly sent in HighefficientFluidbeddrier by wet granular, temperature controls at 65 DEG C, and vapor tension control, at 0.15MPa, is dried to pellet moisture and is down to less than 5%;
(5) granulate: the efficient pelletizing machine of dried granule is passed through 14 mesh sieve granulate;
(6) always mix: the material after granulate is added in two-dimensional motion mixer, add magnesium stearate, orange flavor, Sorbitol, mixing 10min;
(7) tabletting: the hopper that the granule after mixing is placed in rotary tablet machine is carried out tabletting, in tableting processes, every 30min survey sheet is heavy once, controls every sheet at 2.45 ~ 2.50g/ sheet.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265725A (en) * | 2015-05-14 | 2017-01-04 | 北京科信必成医药科技发展有限公司 | A kind of calcium carbonate taste masked particle agent and preparation method thereof |
| CN106619750A (en) * | 2017-02-17 | 2017-05-10 | 王左良 | Ginkgol biloba osteocalcin hard capsules and preparation method thereof |
| CN108721236A (en) * | 2018-06-12 | 2018-11-02 | 贡享本草（永泰）生物科技有限公司 | A kind of roxburgh anoectochilus terminal bud chewable tablets and preparation method thereof |
| CN109846901A (en) * | 2019-04-03 | 2019-06-07 | 江西安顺堂生物科技有限公司 | It is a kind of to promote bone growth, anti-caries, the preparation and preparation process for supplementing calcium |
| CN110122880A (en) * | 2019-06-19 | 2019-08-16 | 安徽康博特保健食品有限公司 | A kind of calcium and magnesium piece health food and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265725A (en) * | 2015-05-14 | 2017-01-04 | 北京科信必成医药科技发展有限公司 | A kind of calcium carbonate taste masked particle agent and preparation method thereof |
| CN106265725B (en) * | 2015-05-14 | 2021-02-09 | 北京科信必成医药科技发展有限公司 | Calcium carbonate taste-masking granules and preparation method thereof |
| CN106619750A (en) * | 2017-02-17 | 2017-05-10 | 王左良 | Ginkgol biloba osteocalcin hard capsules and preparation method thereof |
| CN108721236A (en) * | 2018-06-12 | 2018-11-02 | 贡享本草（永泰）生物科技有限公司 | A kind of roxburgh anoectochilus terminal bud chewable tablets and preparation method thereof |
| CN109846901A (en) * | 2019-04-03 | 2019-06-07 | 江西安顺堂生物科技有限公司 | It is a kind of to promote bone growth, anti-caries, the preparation and preparation process for supplementing calcium |
| CN110122880A (en) * | 2019-06-19 | 2019-08-16 | 安徽康博特保健食品有限公司 | A kind of calcium and magnesium piece health food and preparation method thereof |
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| CN105106154B (en) | 2018-06-29 |
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