CN105106039B - A kind of preparation method of proanthocyanidin Whitening sunscreen cream - Google Patents

A kind of preparation method of proanthocyanidin Whitening sunscreen cream Download PDF

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CN105106039B
CN105106039B CN201510589294.0A CN201510589294A CN105106039B CN 105106039 B CN105106039 B CN 105106039B CN 201510589294 A CN201510589294 A CN 201510589294A CN 105106039 B CN105106039 B CN 105106039B
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proanthocyanidin
sunscreen cream
water
water phase
temperature
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CN105106039A (en
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王飞
刘功骏
周蒙
杨阳
李迅
张瑜
姜萍
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Nanjing Forestry University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Dermatology (AREA)
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  • Engineering & Computer Science (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a kind of preparation methods of proanthocyanidin Whitening sunscreen cream, belong to technical field of skin care.Purpose is to provide for a kind of proanthocyanidin Whitening sunscreen cream scientific formula and its reasonable, high usage suncream preparation method.The present invention is mutually slowly mixed together heat preservation by constant weight number by water phase and oil, and stirring is made, wherein oily phase composition ingredient is oligomeric proanthocyanidins, stearic acid, hexadecanol, isopropyl palmitate, lanolin, olive oil, glycerin monostearate, methylparaben, propylben, water.Water phase constituent glycerol, triethanolamine, lauryl sodium sulfate, water, azone.Whitening sunscreen cream effective component made from the method for the present invention is that oligomeric proanthocyanidins are a kind of natural polyphenol substances, is obtained by macroreticular resin isolation technics to proanthocyanidin purification, has the function of preferable whitening sun protection.

Description

A kind of preparation method of proanthocyanidin Whitening sunscreen cream
Technical field
The invention belongs to technical field of skin care, relate generally to a kind of preparation method of proanthocyanidin Whitening sunscreen cream.
Background technique
When people are when carrying out illumination, ultraviolet light can also be damaged human skin, and not only appearance is impaired, more may be used Skin health can be influenced.Moreover, the destruction of atmospheric ozone layer is also increasingly severe as environmental pollution is increasingly severe, lead The intensity of daylight middle-ultraviolet lamp is caused to become strong, ultraviolet light is also more and more obvious the damage of skin to people under light illumination.
Proanthocyanidin refers to that isolated one kind is extracted from plants can generate red anthocyanidin under hot acidizing Polyphenol compound, there is extremely strong antioxidant activity, inhibit as a kind of good oxygen-cent red radical scavenger and lipid peroxidation Agent, molecular structure unit aromatic rings have multiple o-, m- position activity phenolic hydroxyl groups, are easy to discharge H to all kinds of free radicals, and terminate Free chain reaction, to prevent from aoxidizing.Proanthocyanidin also has good uv absorption property, and research finds proanthocyanidin There is stronger absorption to ultraviolet B radiation (UVB, 280nm-320nm), i.e., has stronger absorption to UVB (ultraviolet B radiation).
Simultaneously because its molecular structure unit aromatic rings there are multiple o-, m- position activity phenolic hydroxyl groups, have to the activity of tyrosinase Stronger inhibiting effect can effectively prevent the generation of melanin, and there is polyhydroxy structure convergence can promote skin-tightening The effect of water conservation.
In addition, proanthocyanidin has preferable sun-proof whitening function, but skin care item rarely have addition proanthocyanidin at present, mainly The reason is that effective component has the risk being destroyed, the sun-proof moisturizing of presently commercially available addition proanthocyanidin when moisturizing creams are made in it Frost is also very low to its utilization rate, and preparation method and formula are not reasonable, it is difficult to reach real whitening sun-proof result, it is therefore desirable to It invents a kind of proanthocyanidin adding method skin cream is made in proanthocyanidin and protect its effective component.
Summary of the invention
In order to overcome the shortcomings of background technique, the present invention provides a kind of preparation methods of proanthocyanidin Whitening sunscreen cream.
It mainly solves existing method and prepares whitening sun protection skin cream and the utilization of oligomeric proanthocyanidins is not enough, prepares Method be formulated it is unreasonable, effective component is low, it is difficult to reach the defect of real whitening anti-sunlight function.Original of the present invention Expect composition and ratio scheme:
A kind of proanthocyanidin Whitening sunscreen cream raw material proportioning: water phase 41.5%, oily phase 58.5%.Water phase composition: glycerol 7%, triethanolamine 0.5%, lauryl sodium sulfate 2%, water 30%, azone 2%.Oily phase composition: oligomeric proanthocyanidins 0.5%-3%, stearic acid 4%, hexadecanol 2%, isopropyl palmitate 4%, lanolin 0.5%, olive oil 1%, monostearate Glyceride 3%, methylparaben 0.15%, propylben.0.05%, water 43.3%-40.8%.
The technical scheme adopted by the invention is that: a kind of method of the preparation of proanthocyanidin Whitening sunscreen cream, including it is following Method and step:
(1) plant that will be enriched in proanthocyanidin, which pulverizes and is sieved, is made 35-55 mesh, powder of the moisture content 12%.
(2) method for using ultrasonic wave assisted extraction, extracts plant powder, filters, recycling design, dry, system Obtain crude proanthocyanidin；
(3) macroporous absorbent resin is used, crude proanthocyanidin is isolated and purified, is evaporated, oligomeric proanthocyanidins are made；
(4) water phase and oily phase of corresponding proportion are prepared by raw material proportioning, and are kept the temperature；
(5) water phase and oil are mutually slowly mixed together heat preservation, stirred；
(6) water phase and oil mixture are cooled to 80 DEG C, azone, vacuum suction is added；
(7) fragrance 3-5 drop is added in slow cooling, stirs, discharging.
In process provided by the invention, it is characterised in that be rich in the plant packet of proanthocyanidin described in step (1) Contain acacia mearnsii, seabuckthorn seeds, peanut red coat, grape pip, pomegranate seed, larch, myrica rubra leaf etc..
In process provided by the invention, it is characterised in that ultrasonic auxiliary extraction method described in step (2) Condition, solvent: 40-70% ethanol water (v/v), the time: 20-30min, temperature: 40-50 DEG C, ultrasonic power: 120- 150W。
In process provided by the invention, it is characterised in that macroporous absorbent resin described in step (3) includes essence Grade AB-8 type resin, BS-30 type resin, BS-45 type resin, D101 type resin etc..
In process provided by the invention, it is characterised in that the process that isolates and purifies in step (3) is using 40% ethyl alcohol Aqueous solution (v/v) carries out affording product；It is evaporated using Rotary Evaporators.
In process provided by the invention, it is characterised in that holding temperature described in step (4) is 80 ± 2 DEG C.
In process provided by the invention, it is characterised in that holding temperature described in step (5) is 85 ± 2 DEG C；It stirs It mixes using mechanical stirring, revolving speed: 500r/min, time: 30min.
In process provided by the invention, it is characterised in that vacuum suction pressure requirements-described in step (6) 0.04mPa, time: 20min.
In process provided by the invention, it is characterised in that 5 ± 1 DEG C/min of rate of temperature fall described in step (7), drop To 45 ± 2 DEG C.Stirring uses mechanical stirring, revolving speed: 500r/min, time: 10min.
The invention difference from existing technology is that the present invention achieves following technical effect: the present invention uses macropore Absorption resin technology isolates and purifies plant proanthocyanidin, using alcohol-water as solvent, is not added and is appointed in operating process using the technology What his organic solvent, it is nontoxic, and have preferable convergence, whitening effect, remove free radical and UV absorption activity, It is provided safeguard for safely preparing for subsequent product.Preparation method of the present invention and formula are more optimized, and effective component is protected, product Homogeneous, color is soft, improves suncream whitening and sunscreen effect, and more to the small target user's range of skin irritation Extensively.Not yet occurs the proanthocyanidin proanthocyanidin Whitening sunscreen cream in acacia mearnsii source on the market at present, which has Good market prospects.
Detailed description of the invention
Fig. 1 is the clearance rate of black wattle bark proanthocyanidin of the invention to free radical of various concentration.
Fig. 2 is that the qualitative determination of skin cream UV absorption is made in the acacia mearnsii proanthocyanidin of various concentration.
Fig. 3 is the inhibiting rate that the acacia mearnsii proanthocyanidin of various concentration inhibits tyrosinase activity.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, technical matters step, condition and material is embodied, to this hair Technical solution in bright embodiment is clearly and completely described, it is clear that described embodiment is only present invention a part Embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not paying wound Every other embodiment obtained under the premise of the property made labour, shall fall within the protection scope of the present invention.
Embodiment 1
Oil in formula is mutually prepared with water phase respectively, Procyanidins 1g, content 1%.It heats and stirs respectively Heat preservation is mixed to 80 DEG C, water phase is slowly added in oily phase, is heated while stirring.85 DEG C are adjusted the temperature to after the entry to be completely, are stirred Mix speed 500r/min, keep 30min, after slow cooling to 80 DEG C, be added azone, and evacuated pressure be- 0.04mPa, time 20min.45 DEG C or so are down to temperature, a small amount of flavors and fragrances is added, continues to stir 10min discharging, Obtained product stability is good, and quality is uniform.
Embodiment 2
Oil in formula is mutually prepared with water phase respectively, Procyanidins 2g, content 2%.It heats and stirs respectively Heat preservation is mixed to 80 DEG C, water phase is slowly added in oily phase, is heated while stirring.85 DEG C are adjusted the temperature to after the entry to be completely, are stirred Mix speed 500r/min, keep 20min, after slow cooling to 80 DEG C, be added azone, and evacuated pressure be- 0.05mPa, time 20min.45 DEG C or so are down to temperature, a small amount of flavors and fragrances is added, continues to stir 10min discharging, Obtained product stability is good, and quality is uniform.
Embodiment 3
Oil in formula is mutually prepared with water phase respectively, Procyanidins 3g, content 3%.It heats and stirs respectively Heat preservation is mixed to 75 DEG C, water phase is slowly added in oily phase, is heated while stirring.80 DEG C are adjusted the temperature to after the entry to be completely, are stirred Mix speed 500r/min, keep 20min, after slow cooling to 80 DEG C, be added azone, and evacuated pressure be- 0.05mPa, time 30min.45 DEG C or so are down to temperature, a small amount of flavors and fragrances is added, continues to stir 10min discharging, Obtained product stability is good, and quality is uniform, but color is deeper.
Embodiment 4
Oil in formula is mutually prepared with water phase respectively, Procyanidins 0.5g, content 0.5%.It heats respectively And heat preservation is stirred to 75 DEG C, water phase is slowly added in oily phase, is heated while stirring.80 are adjusted the temperature to after the entry to be completely DEG C, mixing speed 300r/min, keep 20min, after slow cooling to 80 DEG C, be added azone, and evacuated pressure be- 0.06mPa, time 30min.45 DEG C or so are down to temperature, a small amount of flavors and fragrances is added, continues to stir 10min discharging, Obtained product stability is good, and quality is uniform.
Embodiment 5
Black wattle bark proanthocyanidin oxidation and removing free radicals activity:
Using the proanthocyanidin of the invention for using macroporous absorbent resin to isolate and purify as sample, it is measured by the following method Oxidation and removing free radicals activity.
The DPPH solution for being 40 μ g/ml with 50% ethyl alcohol compound concentration, is scanned at 200-700nm, and measurement is inhaled Receive wavelength.Sample to be tested is prepared with 50% ethyl alcohol, 5 μ g/ml, 10 μ g/ml, 15 μ g/ml, 20 μ g/ml, the sample of 25 μ g/ml are molten Liquid surveys Ai, Aj, Ac after placing 30min at 525nm.
Free radical scavenging activity IP%=[1- (Ai-Aj)/Ac] × 100
In formula: Ai-3mL40 μ g/mLDPPH+0.5mL sample
Aj-3mL50% ethanol solution+0.5mL sample
Ac-3mL40 μ g/mLDPPH+0.5mL ethanol solution
When the proanthocyanidin oligomer concentration of purifying is 25 μ g/ml, free radical scavenging activity is up to 78.82%.
Embodiment 6
The measurement of moisturizing creams UV absorption made of acacia mearnsii proanthocyanidin:
The qualitative survey of GB/T2334-1997 cosmetics middle-ultraviolet lamp absorbent is used with obtained moisturizing cream of the invention Determine method, measures its UV absorption.
There is skin cream made of acacia mearnsii proanthocyanidin certain ultraviolet absorption effect to have stronger suction to 280nm-320nm It receives.
Embodiment 7
Inhibiting effect of the acacia mearnsii proanthocyanidin to tyrosinase activity:
Using the proanthocyanidin of the invention for using macroporous absorbent resin to isolate and purify as sample, it is measured by the following method The effect inhibited tyrosinase activity.
Tyrosine 1mL (3mmol/L) is added in A test tube, 6.8 phosphate buffer 2mL of pH, 30 DEG C of water-baths keep the temperature 10min Afterwards, tyrosinase 1mL (0.04mg/mL) is added to be mixed evenly.It is measured since being uniformly mixed, measurement in every 60 seconds is primary, measures 30min, result OD1.
The concentration gradient of B sample is set as 1:5ug/mL, 2:10ug/mL, 3:15ug/mL, 4:20ug/mL, 5:25ug/mL, 6:30ug/mL, in experiment, taking two test tubes is first and second, and buffer 1.5mL, tyrosine 1mL are added in first test tube, is tried in second Buffer 2.5mL, tyrosine 1mL are added in pipe, after ten minutes, sample 0.5mL, tyrosine is added in common water-bath in first test tube Sample 0.5mL is added in second test tube by enzyme 1mL, is uniformly mixed, and measures since being uniformly mixed, using uv analyzer in 475nm Place's measurement light absorption value, the measurement of second test tube is primary, and result OD2, second test tube measures the light absorption value in 30 minutes, if between two minutes Every, survey 16 times, result OD3.The sample of the various concentration of different molecular weight cut off is all as the above method measures.
Inhibiting rate Ip%=[1- (OD3-OD2)/OD1] × 100
Test result shows that when the proanthocyanidin oligomer concentration of purifying is 30 μ g/ml, free radical scavenging activity reaches 80.43%.
Embodiment 8
Protective effect of the moisturizing creams to mouse ultraviolet injury resistant made of acacia mearnsii proanthocyanidin:
Using manufactured moisturizing creams of the invention as sample, it is studied by the following method, mouse ultraviolet injury resistant is protected Shield effect.
The only 2d before testing of weight 20 ± 2gICR cleaning grade mouse 50 is taken, sloughs back coat with 8% vulcanized sodium, exposure Area 4cm × 3cm.Mouse is randomly divided into positive controls (10), blank control group (10), model group by 2d after depilation (15) and test group (15).
Before on-test, by the different ultraviolet protection product of the preventative smearing of each group mouse, positive controls smear suncream (to 0.3g, every ear is to 0.1g at every back), blank control group and model group smearing are added without skin cream made of effective component (to 0.3g, every ear is to 0.1g at every back), test group smears skin cream made of addition effective component, and (every back is given 0.3g, every ear is to 0.1g), drug is applied to back and the ears of mouse by groups of animals, 2 times/d, smears 3d altogether.Except blank pair Outer according to group, mouse is horizontally fixed on brandreth by remaining each group, with ultraviolet lamp vertical range 15cm, 6h is irradiated, during irradiation Animal head is covered with processed medical proof fabric, animal eyes are shot wounded with antiultraviolet, cause skin lesion mouse model.
Skin lesion mouse is observed, with skin keratinization and husking for index, visually observes the back of mice after ultraviolet light irradiates Change of skin situation.Skin lesion mouse model Continuous irradiation ultraviolet light 40h, the ridge that breaks put to death mouse, weigh mouse weight and record, then The round auricle and skin graft of two ears and back 9mm diameter, its ear of accurate weighing weight and tare weight are taken respectively, calculate ear index and skin refers to Number, middle ear index=ear weight/weight, skin index=tare weight/weight.
Test result is the ear index of positive controls, skin index is 1.04mgg-1、2.85mg·g-1, blank control Ear index, the skin index of group are 0.86mgg-1、2.62mg·g-1, ear index, the skin index of test group are 0.97mgg-1、 2.97mg·g-1, ear index, the skin index of model group are 1.12mgg-1、4.59mg·g-1.It can obtain by comparing, acacia mearnsii Moisturizing creams made of proanthocyanidin have certain protective effect to mouse ultraviolet injury, have with commercially available moisturizing creams similar Effect.
Every technical staff's notice: of the invention although the present invention is described according to above-mentioned specific embodiment Invention thought be not limited in the invention, any repacking with inventive concept will all be included in this patent protection of the patent right In range.

Claims (6)

1. a kind of proanthocyanidin Whitening sunscreen cream, it is characterised in that raw material proportioning are as follows: water phase 41.5%, oily phase 58.5%；
Water phase composition: glycerol 7%, triethanolamine 0.5%, lauryl sodium sulfate 2%, water 30%, azone 2%；
Oily phase composition: oligomeric proanthocyanidins 0.5%-3%, stearic acid 4%, hexadecanol 2%, isopropyl palmitate 4%, lanolin 0.5%, olive oil 1%, glycerin monostearate 3%, methylparaben 0.15%, propylben 0.05%, water 43.3%- 40.8%；
The preparation method of the proanthocyanidin Whitening sunscreen cream the following steps are included:
(1) plant that will be enriched in proanthocyanidin, which pulverizes and is sieved, is made 35-55 mesh, powder of the moisture content 12%；
(2) method for using ultrasonic wave assisted extraction, extracts plant powder, filters, recycling design, dry, is made thick Proanthocyanidin processed；
(3) crude proanthocyanidin is isolated and purified using macroporous absorbent resin, is evaporated, oligomeric proanthocyanidins are made；
(4) water phase and oily phase of corresponding proportion are prepared by the raw material proportioning, and are kept the temperature at 80 ± 2 DEG C；
(5) water phase and oil are mutually slowly mixed together, are kept the temperature at 85 ± 2 DEG C, stirs 30min at 500r/min；
(6) water phase and oil mixture are cooled to 80 DEG C, azone, vacuum suction is added；
(7) slow cooling, 5 ± 1 DEG C/min of rate of temperature fall are down to 45 ± 2 DEG C, and fragrance 3-5 drop is added, and stir, discharging；
The condition of the ultrasonic auxiliary extraction method, solvent: 40-70% ethanol water (v/v), the time: 20-30min, Temperature: 40-50 DEG C, ultrasonic power: 120-150W；
The plant rich in proanthocyanidin is acacia mearnsii.
2. proanthocyanidin Whitening sunscreen cream preparation method described in a kind of claim 1, comprising the following steps:
(1) plant that will be enriched in proanthocyanidin, which pulverizes and is sieved, is made 35-55 mesh, powder of the moisture content 12%；
(2) method for using ultrasonic wave assisted extraction, extracts plant powder, filters, recycling design, dry, is made thick Proanthocyanidin processed；
(3) crude proanthocyanidin is isolated and purified using macroporous absorbent resin, is evaporated, oligomeric proanthocyanidins are made；
(4) water phase and oily phase of corresponding number are prepared by claim 1 formula, and are kept the temperature at 80 ± 2 DEG C；
(5) water phase and oil are mutually slowly mixed together, are kept the temperature at 85 ± 2 DEG C, stirs 30min at 500r/min；
(6) water phase and oil mixture are cooled to 80 DEG C, azone, vacuum suction is added；
(7) slow cooling, 5 ± 1 DEG C/min of rate of temperature fall are down to 45 ± 2 DEG C, and fragrance 3-5 drop is added, stirs at 500r/min 10min, discharging；
The condition of the ultrasonic auxiliary extraction method, solvent: 40-70% ethanol water (v/v), the time: 20-30min, Temperature: 40-50 DEG C, ultrasonic power: 120-150W.
3. proanthocyanidin Whitening sunscreen cream preparation method according to claim 2, it is characterised in that richness described in step (1) Plant containing proanthocyanidin is acacia mearnsii.
4. proanthocyanidin Whitening sunscreen cream preparation method according to claim 2, it is characterised in that big described in step (3) Macroporous adsorbent resin includes AB-8 type resin, BS-30 type resin, BS-45 type resin and D101 type resin.
5. proanthocyanidin Whitening sunscreen cream preparation method according to claim 2, it is characterised in that step isolates and purifies in (3) Process is to carry out affording product using 40% ethanol water (v/v)；It is evaporated using Rotary Evaporators.
6. proanthocyanidin Whitening sunscreen cream preparation method according to claim 2, it is characterised in that true described in step (6) Empty pump air pressure force request -0.04MPa, time: 20min.
CN201510589294.0A 2015-09-17 2015-09-17 A kind of preparation method of proanthocyanidin Whitening sunscreen cream Active CN105106039B (en)

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CN107802525A (en) * 2017-12-21 2018-03-16 广东石油化工学院 A kind of stilbene glucoside in polygonum multiflorum sunscreen
CN108553368A (en) * 2018-06-12 2018-09-21 临沂大学 A kind of snake gourd fruit pulp skin whitener and its preparation process

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CN103251674A (en) * 2013-05-30 2013-08-21 南京林业大学 Black wattle bark proanthocyanidin microcapsule and preparation method thereof
CN103520023A (en) * 2013-10-28 2014-01-22 西北农林科技大学 Sunscreen cream rich in grape seed oil and procyanidine
CN103536495A (en) * 2013-10-28 2014-01-29 西北农林科技大学 Preparation method of grape seed procyanidin sun cream
CN103923052A (en) * 2014-04-09 2014-07-16 完美（中国）有限公司 Method for preparing oligomeric proanthocyanidins

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Publication number Priority date Publication date Assignee Title
CN103251674A (en) * 2013-05-30 2013-08-21 南京林业大学 Black wattle bark proanthocyanidin microcapsule and preparation method thereof
CN103520023A (en) * 2013-10-28 2014-01-22 西北农林科技大学 Sunscreen cream rich in grape seed oil and procyanidine
CN103536495A (en) * 2013-10-28 2014-01-29 西北农林科技大学 Preparation method of grape seed procyanidin sun cream
CN103923052A (en) * 2014-04-09 2014-07-16 完美（中国）有限公司 Method for preparing oligomeric proanthocyanidins

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