CN105104394A - 化合物23-反式-对-香豆酰委陵菜酸的应用 - Google Patents
化合物23-反式-对-香豆酰委陵菜酸的应用 Download PDFInfo
- Publication number
- CN105104394A CN105104394A CN201510613833.XA CN201510613833A CN105104394A CN 105104394 A CN105104394 A CN 105104394A CN 201510613833 A CN201510613833 A CN 201510613833A CN 105104394 A CN105104394 A CN 105104394A
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- CN
- China
- Prior art keywords
- trans
- compound
- tormentic acid
- coumaroyl
- para
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OXVUXGFZHDKYLS-BLIWDXROSA-N Tormentic acid Natural products C1[C@@H](O)[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@](O)(C)[C@H]5C4=CC[C@@H]3[C@]21C OXVUXGFZHDKYLS-BLIWDXROSA-N 0.000 title claims abstract description 16
- VULLSLYDWNGNKZ-UHFFFAOYSA-N 12319Tetrahydroxyurs-12-en-28-oic acid Natural products OC1C(O)C(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)C(O)(C)C5C4=CCC3C21C VULLSLYDWNGNKZ-UHFFFAOYSA-N 0.000 title claims abstract description 15
- OXVUXGFZHDKYLS-UHFFFAOYSA-N Jacarandic acid Natural products C1C(O)C(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)C(O)(C)C5C4=CCC3C21C OXVUXGFZHDKYLS-UHFFFAOYSA-N 0.000 title claims abstract description 15
- -1 tormentic acid compound Chemical class 0.000 title claims abstract description 15
- 150000001875 compounds Chemical class 0.000 claims abstract description 18
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims description 6
- 239000000645 desinfectant Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000009736 wetting Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 238000013268 sustained release Methods 0.000 claims description 2
- 239000012730 sustained-release form Substances 0.000 claims description 2
- 244000299906 Cucumis sativus var. sativus Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 239000000575 pesticide Substances 0.000 abstract description 6
- 229930014626 natural product Natural products 0.000 abstract description 3
- 150000002611 lead compounds Chemical class 0.000 abstract description 2
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000447 pesticide residue Substances 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 6
- 240000008067 Cucumis sativus Species 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 239000012488 sample solution Substances 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 241000123650 Botrytis cinerea Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 150000003648 triterpenes Chemical class 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000009191 jumping Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 0 *OC(C=Cc(cc1)ccc1O)=O Chemical compound *OC(C=Cc(cc1)ccc1O)=O 0.000 description 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 241000500881 Lepisma Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 206010039105 Rhinoviral infections Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000710960 Sindbis virus Species 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 229960003942 amphotericin b Drugs 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000002026 chloroform extract Substances 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- OOTXFYSZXCPMPG-BMYLZFHVSA-N ursane Chemical compound C1CCC(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5[C@H]4CC[C@@H]3[C@]21C OOTXFYSZXCPMPG-BMYLZFHVSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Landscapes
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510613833.XA CN105104394B (zh) | 2015-09-24 | 2015-09-24 | 化合物23‑反式‑对‑香豆酰委陵菜酸的应用 |
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CN201510613833.XA CN105104394B (zh) | 2015-09-24 | 2015-09-24 | 化合物23‑反式‑对‑香豆酰委陵菜酸的应用 |
Publications (2)
Publication Number | Publication Date |
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CN105104394A true CN105104394A (zh) | 2015-12-02 |
CN105104394B CN105104394B (zh) | 2017-12-26 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020161221A1 (en) | 2019-02-07 | 2020-08-13 | Luxembourg Institute Of Science And Technology (List) | METHOD FOR PRODUCING A COMPOSITION COMPRISING A 3-O-p-COUMAROYL ESTER OF TORMENTIC ACID FROM A PLANT CELL CULTURE, APPLICATIONS THEREOF AS ANTIPARASITIC AGENT FOR THE TREATMENT OF TRYPANOSOMIASIS |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101172131A (zh) * | 2006-11-01 | 2008-05-07 | 中国医药研究开发中心有限公司 | 委陵菜属植物总三萜提取物的制备方法 |
CN104381343A (zh) * | 2013-09-17 | 2015-03-04 | 闽南师范大学 | 一种水溶性复配抑菌剂及其制备方法 |
-
2015
- 2015-09-24 CN CN201510613833.XA patent/CN105104394B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101172131A (zh) * | 2006-11-01 | 2008-05-07 | 中国医药研究开发中心有限公司 | 委陵菜属植物总三萜提取物的制备方法 |
CN104381343A (zh) * | 2013-09-17 | 2015-03-04 | 闽南师范大学 | 一种水溶性复配抑菌剂及其制备方法 |
Non-Patent Citations (2)
Title |
---|
TOMMASI ET AL: "Constituents of Eriobotrya japonica a study of their Antiviral Propreties", 《JOURNAL OF NATURAL PRODUCTS》 * |
吕寒等: "枇杷叶中三萜类化学成分的研究", 《中药材》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020161221A1 (en) | 2019-02-07 | 2020-08-13 | Luxembourg Institute Of Science And Technology (List) | METHOD FOR PRODUCING A COMPOSITION COMPRISING A 3-O-p-COUMAROYL ESTER OF TORMENTIC ACID FROM A PLANT CELL CULTURE, APPLICATIONS THEREOF AS ANTIPARASITIC AGENT FOR THE TREATMENT OF TRYPANOSOMIASIS |
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Publication number | Publication date |
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CN105104394B (zh) | 2017-12-26 |
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Address after: On the south side of Huiyuan Road Economic Development Zone in Shanghe County of Ji'nan City, Shandong province 251600 Applicant after: SHANDONG TANG PU LE CROP SCIENCE CO.,LTD. Address before: On the south side of Huiyuan Road Economic Development Zone in Shanghe County of Ji'nan City, Shandong province 251600 Applicant before: SHANDONG XINGHE CROP SCIENCE TECHNOLOGY Co.,Ltd. |
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Inventor after: Niu Shanguang Inventor after: Du Fengyu Inventor after: Zhang Shujing Inventor after: Li Xinghe Inventor before: Niu Shanguang Inventor before: Du Fengyu Inventor before: Zhang Shujing Inventor before: Li Qinghe |
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Denomination of invention: Application of 23-trans-para-coumaroyl tormentic acid compound Effective date of registration: 20180528 Granted publication date: 20171226 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan industrial North Branch Branch Pledgor: SHANDONG TANG PU LE CROP SCIENCE CO.,LTD. Registration number: 2018370000102 |
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Date of cancellation: 20180731 Granted publication date: 20171226 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan industrial North Branch Branch Pledgor: SHANDONG TANG PU LE CROP SCIENCE CO.,LTD. Registration number: 2018370000102 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
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Denomination of invention: Application of compound 23 trans P coumaric acid Effective date of registration: 20220308 Granted publication date: 20171226 Pledgee: Ji'nan rural commercial bank Limited by Share Ltd. high tech branch Pledgor: SHANDONG TANG PU LE CROP SCIENCE CO.,LTD. Registration number: Y2022980002296 |
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Date of cancellation: 20221212 Granted publication date: 20171226 Pledgee: Ji'nan rural commercial bank Limited by Share Ltd. high tech branch Pledgor: SHANDONG TANG PU LE CROP SCIENCE CO.,LTD. Registration number: Y2022980002296 |
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Denomination of invention: Application of compound 23 trans para coumarin valeric acid Effective date of registration: 20230327 Granted publication date: 20171226 Pledgee: Shandong Shanghe Rural Commercial Bank Co.,Ltd. Yuhuangmiao Sub branch Pledgor: SHANDONG TANG PU LE CROP SCIENCE CO.,LTD. Registration number: Y2023980036146 |