CN105102117A - 作为用于液体技术的载体的多孔硅胶 - Google Patents

作为用于液体技术的载体的多孔硅胶 Download PDF

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Publication number
CN105102117A
CN105102117A CN201480019478.7A CN201480019478A CN105102117A CN 105102117 A CN105102117 A CN 105102117A CN 201480019478 A CN201480019478 A CN 201480019478A CN 105102117 A CN105102117 A CN 105102117A
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CN
China
Prior art keywords
inorganic oxide
compositions according
oxide particles
particle
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480019478.7A
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English (en)
Chinese (zh)
Inventor
F.H.蒙苏尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WR Grace and Co Conn
Original Assignee
WR Grace and Co Conn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WR Grace and Co Conn filed Critical WR Grace and Co Conn
Priority to CN202010078625.5A priority Critical patent/CN111389345A/zh
Publication of CN105102117A publication Critical patent/CN105102117A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B01J20/28059—Surface area, e.g. B.E.T specific surface area being less than 100 m2/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
    • B01J20/28073—Pore volume, e.g. total pore volume, mesopore volume, micropore volume being in the range 0.5-1.0 ml/g
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/113—Silicon oxides; Hydrates thereof
    • C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
    • C01B33/18—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof
    • C01B33/187—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof by acidic treatment of silicates
    • C01B33/193—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof by acidic treatment of silicates of aqueous solutions of silicates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Silicon Compounds (AREA)
CN201480019478.7A 2013-02-01 2014-01-30 作为用于液体技术的载体的多孔硅胶 Pending CN105102117A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010078625.5A CN111389345A (zh) 2013-02-01 2014-01-30 作为用于液体技术的载体的多孔硅胶

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361759723P 2013-02-01 2013-02-01
US61/759723 2013-02-01
PCT/US2014/013848 WO2014120922A1 (en) 2013-02-01 2014-01-30 Porous silica gel as a carrier for liquid technologies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202010078625.5A Division CN111389345A (zh) 2013-02-01 2014-01-30 作为用于液体技术的载体的多孔硅胶

Publications (1)

Publication Number Publication Date
CN105102117A true CN105102117A (zh) 2015-11-25

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201480019478.7A Pending CN105102117A (zh) 2013-02-01 2014-01-30 作为用于液体技术的载体的多孔硅胶
CN202010078625.5A Pending CN111389345A (zh) 2013-02-01 2014-01-30 作为用于液体技术的载体的多孔硅胶

Family Applications After (1)

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CN202010078625.5A Pending CN111389345A (zh) 2013-02-01 2014-01-30 作为用于液体技术的载体的多孔硅胶

Country Status (9)

Country Link
US (1) US10660856B2 (enExample)
EP (1) EP2950923B1 (enExample)
JP (2) JP6513031B2 (enExample)
KR (1) KR102229036B1 (enExample)
CN (2) CN105102117A (enExample)
ES (1) ES2908958T3 (enExample)
HK (1) HK1217927A1 (enExample)
PL (1) PL2950923T3 (enExample)
WO (1) WO2014120922A1 (enExample)

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US11633409B2 (en) * 2017-09-01 2023-04-25 Jw Pharmaceutical Corporation Solid preparation comprising dutasteride and method for preparing same
EP3862318A4 (en) * 2018-10-05 2022-06-15 Fuji Chemical Industry Co., Ltd. Porous silica particle composition
WO2020077451A1 (en) 2018-10-16 2020-04-23 Silicycle Inc. Tunable process for silica capsules/spheres preparation and their use
US12459829B2 (en) 2018-11-07 2025-11-04 Disruptive Pharma Ab Amorphous active pharmaceutical ingredients comprising substantially amorphous mesoporous magnesium carbonate
CN111751480B (zh) * 2020-07-16 2021-06-15 北京理工大学 一种维生素e琥珀酸聚乙二醇酯的应用
EP4188329A4 (en) * 2020-07-29 2024-08-14 Kydes Pharmaceuticals, LLC PHARMACEUTICAL FORMULATIONS CONTAINING TADALAFIL
GB202014184D0 (en) 2020-09-09 2020-10-21 Johnson Matthey Plc Modifed catalyst supports and catalysts supported thereon
JP7575266B2 (ja) * 2020-12-25 2024-10-29 Ａｇｃ株式会社 シリカ粒子及びその用途、並びにシリカ粒子の製造方法
CA3250089A1 (en) * 2022-11-14 2024-05-23 Medisca Pharmaceutique Inc. Methods and systems for making oil-loaded powders and use thereof
CN116159031B (zh) * 2023-02-22 2023-08-22 上海国创医药股份有限公司 一种马来酸氟伏沙明片剂及其制备方法
GB2634526A (en) 2023-10-11 2025-04-16 Univ Sheffield A method of manufacturing porous silicon

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CN1649507A (zh) * 2002-04-30 2005-08-03 埃迪塞欧爱尔兰有限公司 动物饲料添加剂
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Also Published As

Publication number Publication date
JP6513031B2 (ja) 2019-05-15
EP2950923A4 (en) 2016-10-19
EP2950923B1 (en) 2022-03-09
PL2950923T3 (pl) 2022-04-04
US10660856B2 (en) 2020-05-26
JP2019048819A (ja) 2019-03-28
US20150366805A1 (en) 2015-12-24
JP2016508502A (ja) 2016-03-22
CN111389345A (zh) 2020-07-10
ES2908958T3 (es) 2022-05-04
EP2950923A1 (en) 2015-12-09
KR102229036B1 (ko) 2021-03-17
WO2014120922A1 (en) 2014-08-07
KR20150115860A (ko) 2015-10-14
HK1217927A1 (zh) 2017-01-27
JP6861679B2 (ja) 2021-04-21

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