CN105079425A - 一种治疗小儿手足口病的组合物制剂及其制备方法 - Google Patents
一种治疗小儿手足口病的组合物制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗小儿手足口病的组合物制剂,取下述重量配比的主要原料制备而成:白鲜皮3-9份,蚤休15-30份,花椒10-30份,薄荷3-9份,金银花3-10份,艾叶15-30份,半枝莲15-30份,野菊花10-20份,土荆皮10-20份,百合5-9份,青蒿3-6份,红景天3-15份,青黛15-40份,甘草10-30份,炉甘石1-3份。该组合物制剂对小儿手足口病效果显著,不仅有止痒、抑菌的功效,还有治疗湿疹、荨麻疹的作用,本发明多选用地方常见药材,价格低廉,减轻了患者的经济负担。
Description
技术领域
本发明属中医中药领域,涉及了一种治疗小儿手足口病的组合物制剂,尤其是一种治疗小儿手足口病的组合物制剂的制备方法。
背景技术
手足口病是由肠道病毒引起的传染病,多发生于5岁以下儿童,可引起手、足、口腔等部位的疱疹,少数患儿可引起心肌炎、肺水肿、无菌性脑膜脑炎等并发症。个别重症患儿如果病情发展快,导致死亡。引发手足口病的肠道病毒有20多种(型),柯萨奇病毒A组的16、4、5、9、10型,B组的2、5型,以及肠道病毒71型,均为手足口病较常见的病原体,其中以柯萨奇病毒A16型(CoxA16)和肠道病毒71型(EV71)最为常见。有数种病毒可引起手足口病。最常见的是柯萨奇病毒A16型,此外柯萨奇病毒A的其他株或肠道病毒71型也可引起手足口病。柯萨奇病毒是肠道病毒的一种。肠道病毒包括脊髓灰质炎病毒、柯萨奇病毒和埃可病毒。其感染部位是包括口腔在内的整个消化道,通过污染的食物、饮料、水果等经口进入体内,并在肠道增殖。
临床表现:手足口病主要发生在4岁以下的儿童,但成人也有可能得病,因此可以说每个人都是易感的。感染后只获得该型别病毒的免疫力,对其他型别病毒再感染无交叉免疫,即患手足口病后还可能因感染其他型别病毒而再次患手足口病。潜伏期:多为2~10天,平均3~5天。1.普通病例表现:急性起病,发热,口腔黏膜出现散在疱疹,手、足和臀部出现斑丘疹、疱疹,疱疹周围可有炎性红晕,疱内液体较少。可伴有咳嗽、流涕、食欲不振等症状。部分病例仅表现为皮疹或疱疹性咽峡炎。多在一周内痊愈,预后良好。部分病例皮疹表现不典型,如单一部位或仅表现为斑丘疹。2.重症病例表现:少数病例(尤其是小于3岁者)病情进展迅速,在发病1~5天左右出现脑膜炎、脑炎(以脑干脑炎最为凶险)、脑脊髓炎、肺水肿、循环障碍等,极少数病例病情危重,可致死亡,存活病例可留有后遗症。(1)神经系统表现:精神差、嗜睡、易惊、头痛、呕吐、谵妄甚至昏迷;肢体抖动,肌阵挛、眼球震颤、共济失调、眼球运动障碍;无力或急性弛缓性麻痹;惊厥。查体可见脑膜刺激征,腱反射减弱或消失,巴氏征等病理征阳性。(2)呼吸系统表现:呼吸浅促、呼吸困难或节律改变,口唇发绀,咳嗽,咳白色、粉红色或血性泡沫样痰液;肺部可闻及湿啰音或痰鸣音。(3)循环系统表现:面色苍灰、皮肤花纹、四肢发凉,指(趾)发绀;出冷汗;毛细血管再充盈时间延长。心率增快或减慢,脉搏浅速或减弱甚至消失;血压升高或下降。急性起病,发热;口腔黏膜出现散状疱疹,米粒大小,疼痛明显;手掌或脚掌部出现米粒大小疱疹,臀部或膝盖偶可受累。疱疹周围有炎性红晕,疱内液体较少。部分患儿可伴有咳嗽、流涕、食欲不振、恶心、呕吐、头疼等状。医生通常能根据病人的年龄、病人或家长的诉说的症状,及检查皮疹和溃疡来鉴别手足口病和其他原因所致的口腔溃疡。可将咽拭子或粪便标本送至实验室检测病毒,但病毒检测需要2~4周才能出结果,因此医生通常不提出做此项检查。依据流行病学资料、临床表现、实验室检查、确诊时须有病原学的检查依据。
中医在缓解小儿手足口病过程中讲究辩证施治,根据患者的不同情况进行辩证治疗,这样可以让患者从病因入手进行治疗,得到很好的对症治疗的效果。公开号授权公告号CN102423447B(申请号201110378341.9)的中国专利文献公开了一种预防和治疗小儿手足口病的中药组合物,由丝瓜络10g,大黄30g,五倍子10g,蛇床子35g,炉甘石20g,海蜇皮8g,藿香5g,寒水石4g,桂枝15g,羌活20g,独活18g,威灵仙15g,海桐皮10g,砂仁8g,豆蔻8g,薏苡仁20g,地耳草15g,鸡骨草10g,炉甘石12g,斑蝥5g制备而成。授权公告号CN102499965B(申请号201110443224.6)的中国专利文献公开了一种预防手足口病的熏蒸中药组合物,它是由下述重量份的中药原料配制而成的,苏合香30、干浮萍30、艾叶30、芦荟20、艾叶25、香附25、青蒿子30、藿香30、佩兰20、樟脑15,它的使用方法是,将苏合香30、干浮萍30、艾叶30、芦荟20、艾叶25、香附25、青蒿子30、藿香30、佩兰20、樟脑15共放在一个大砂锅内添水过药高5厘米浸泡20分钟用武火熬开后,然后用中火熬30-45分钟,小型场所设1个点,大型可分3-5个点,每2天熏蒸一次即可。
以上各种缓解小儿手足口病的药物,不管是中药还是西药均出现不同疗效,大大减轻了病人的痛苦,不足之处是用药周期长,易复发。
发明内容
随着中国中医中药学的不断发展,在治疗与预防小儿手足口病上,人们渐渐意识到了中药治疗小儿手足口病治疗过程无副作用,患者承受痛苦小,造价相对节省的优势,针对现有西医治疗小儿手足口病的现状,本发明的目的之一在于提供一种治疗小儿手足口病的组合物制剂,具有易操作、疗效显著的特点,并且它采用地方上较为常见的中药材作为原料,成本低廉。
本发明的上述目的是通过以下技术方案来实现的:
一种治疗小儿手足口病的组合物制剂,取下述重量配比的主要原料制备而成:白鲜皮3-9份,蚤休15-30份,花椒10-30份(优选的,花椒10.5-29.5份),薄荷3-9份,金银花3-10份,艾叶15-30份,半枝莲15-30份,野菊花10-20份,土荆皮10-20份,百合5-9份,青蒿3-6份,红景天3-15份,青黛15-40份,甘草10-30份,炉甘石1-3份。
一种治疗小儿手足口病的组合物制剂,优选的,取下述重量配比的主要原料制备而成:白鲜皮5-9份,蚤休16-25份,花椒15-25份,薄荷4-8份,金银花4-8份,艾叶18-28份,半枝莲18-25份,野菊花12-18份,土荆皮14-18份,百合6-8份,青蒿3.5-5份,红景天6-14份,青黛20-38份,甘草15-28份,炉甘石1.5-2.5份。
一种治疗小儿手足口病的组合物制剂,最优的,取下述重量配比的主要原料制备而成:白鲜皮8份,蚤休20份,花椒20份,薄荷6份,金银花5份,艾叶20份,半枝莲20份,野菊花15份,土荆皮15份,百合7份,青蒿4份,红景天12份,青黛30份,甘草25份,炉甘石2份。
本发明的另一目的就是提供上述治疗小儿手足口病的制备方法。
一种治疗小儿手足口病的组合物制剂的制备方法,主要由下述步骤制备而成:
①将花椒和薄荷打碎用温水浸泡30-50分钟,用武火烧开后通入水蒸气蒸馏50-70分钟,使挥发油与水一同蒸馏出来,收集蒸馏液,静置1-3小时,馏液冷却至室温,取上层油液待用。
②将白鲜皮、蚤休和金银花用苦瓜汁拌匀,苦瓜汁是白鲜皮、蚤休和金银花用量的2-4倍,浸泡1-3小时,取出烘制酥脆,研磨成细末待用;
③将炉甘石置于无烟的炉火上,锻制酥脆,研磨成细末,过100-140目筛待用;
④将艾叶、半枝莲、野菊花、土荆皮、百合、青蒿、红景天和甘草加水煎煮两次,每次都是先大火煮沸,在转文火煎煮20-40分钟,两次滤液混匀,置于砂锅内,加入步骤②、③所得物和青黛,一边搅拌一边煎煮5-15分钟,过滤,滤液静置5-10小时,得上清液,将步骤①所得油液与上清液混匀,装瓶后上下左右各摇晃15下即得。
上述组合物制剂的制备方法,步骤①将花椒和薄荷打碎用温水浸泡35-45分钟,用武火烧开后通入水蒸气蒸馏55-65分钟(优选的,将花椒和薄荷打碎用温水浸泡40分钟,用武火烧开后通入水蒸气蒸馏60分钟)。
上述组合物制剂的制备方法,步骤①收集蒸馏液,静置1.5-2.5小时(优选的,收集蒸馏液,静置2小时)。
上述组合物制剂的制备方法,步骤②苦瓜汁是白鲜皮、蚤休和金银花用量的2.5-3.5倍,浸泡1.5-2.5小时(优选的,苦瓜汁是白鲜皮、蚤休和金银花用量的3倍,浸泡2小时)。
上述组合物制剂的制备方法,步骤③细末过110-130目筛待用(优选的,细末过120目筛待用)。
上述组合物制剂的制备方法,步骤④在转文火煎煮25-35分钟(优选的,在转文火煎煮30分钟)。
上述组合物制剂的制备方法,步骤④一边搅拌一边煎煮8-13分钟,过滤,滤液静置6-9小时(优选的,一边搅拌一边煎煮10分钟,过滤,滤液静置7.5小时)。
该组合物制剂对小儿手足口病效果显著,不仅有止痒、抑菌的功效,还有治疗湿疹、荨麻疹的作用,本发明多选用地方常见药材,价格低廉,减轻了患者的经济负担。
所述各原料药的药理功效分别为:
白鲜皮:别名:北鲜皮、藓皮、野花椒根皮、臭根皮。性味:苦;咸;寒。归经:脾经;肺经;小肠经;胃经;膀胱经。功能:清热燥湿;祛风止痒;解毒。主治:风热湿毒所致的风疹;湿疹;疥癣;黄疸;湿热痹。
蚤休:七叶一枝花根含蚤休甙、薯蓣皂甙,薯蓣皂甙元的3-葡萄糖甙、3-鼠李糖葡萄糖甙、3-鼠李糖阿拉伯糖葡萄糖甙和3-四糖甙,娠二烯醇酮-3-查考茄三糖甙等多种皂甙。中药蚤休为百合科植物七叶一枝花、金线重楼及其数种同属植物的根茎。其功能有:清热解毒,平喘止咳,熄风定惊,消肿止血。主治:痈肿,疔疮,瘰疬,喉痹,慢性气管炎,小儿惊风抽搐,蛇虫咬伤,妇女经血不调,跌打损伤。
花椒:中医认为,花椒性温,味辛,有温中散寒、健胃除湿、止痛杀虫、解毒理气、止痒祛腥的功效;可用于治疗积食、停饮、呃逆、呕吐、风寒湿邪所致的关节肌肉疼痛、脘腹冷痛、泄泻、痢疾、蛔虫、阴痒等病症。功能主治:温中散寒,除湿,止痛,杀虫,解鱼腥毒。治积食停饮,心腹冷痛,呕吐,噫呃,咳嗽气逆,风寒湿痹,泄泻,痢疾,疝痛,齿痛,蛔虫病,蛲虫病,阴痒,疮疥。
薄荷:薄荷是中华常用中药之一。它是辛凉性发汗解热药,治流行性感冒、头疼、目赤、身热、咽喉、牙床肿痛等症。外用可治神经痛、皮肤瘙痒、皮疹和湿疹等。平常以薄荷代茶,清心明目。
金银花:金银花性寒,味甘,入肺、心、胃经,具有清热解毒、抗炎、补虚疗风的功效,主治胀满下疾、温病发热,热毒痈疡和肿瘤等症。其对于头昏头晕、口干作渴、多汗烦闷、肠炎、菌痢、麻疹、肺炎、乙脑、流脑、急性乳腺炎、败血症、阑尾炎、皮肤感染、痈疽疔疮、丹毒、腮腺炎、化脓性扁桃体炎等病症均有一定疗效。
艾叶:辛、苦,温。归经:归肝、脾、肾经。功效:温经止血,散寒止痛;外用祛湿止痒。主治:用于吐血,衄血,崩漏,月经过多,胎漏下血,少腹冷痛,经寒不调,宫冷不孕;外治皮肤瘙痒。醋艾炭温经止血,用于虚寒性出血。
半枝莲:半支莲全草入药,具有清热解毒、活血祛瘀、消肿止痛、抗癌等功能。性寒味酸,全草含多种维生素、微量元素及氨基酸等成分。有凉血解毒,散瘀止痛,消肿和清热利湿之功效。
野菊花:为菊科菊属植物野菊或岩香菊的根或全草。药性:苦、辛,寒。归肝、心经。功用主治:清热解毒,明目。主治感冒,痢疾,痈肿,疔疮,目赤肿痛,眩晕,瘰疬,湿疹。
土荆皮:又名罗汉松皮、荆树皮、金钱松皮,为松科金钱松属植物金钱松的根皮及近根树皮。药性:根皮呈不规则的长条状,扭曲而稍卷,大小不一,质韧,气微,味辛、苦,性温。成分:根皮含土荆皮酸,白桦脂酸,杨梅树皮素,苦杏碱醇A和B等。根据现代药理研究发现,该药具有抗真菌、抗癌、祛风除湿、杀虫止痒的功效,用于湿疹,神经性皮炎。
百合:甘;微苦;微寒,野生百合全株归经心;肺经,功能主治:养阴润肺;清心安神。主阴虚久嗽;痰中带血;热病后期;余热未清,或情志不遂所致的虚烦惊悸、失眠多梦、精神恍惚;痈肿;湿疮。
青蒿:清透虚热,凉血除蒸,解暑,截疟。用于暑邪发热,阴虚发热,夜热早凉,骨蒸劳热,疟疾寒热,湿热黄疸。该品苦寒清热,辛香透散,善使阴分伏热透达外散,为阴虚发热要药,此外兼有解暑,截虐之功。1,解暑:可治外感暑热,发热烦渴。2,截虐:主治疟疾引起的寒热往来。3,凉血,退虚热:善治阴虚发热,骨蒸劳热,及温热病后期,热入阴分,夜热早凉者。
红景天:性味:寒、甘、涩。归经:肺经。功能主治:有补气清肺、益智养心、收涩止血、散瘀消肿的功效。主治气虚体弱、病后畏寒、气短乏力、肺热咳嗽、咯血、白带腹泻、跌打损伤等。
青黛:又名青蛤粉、靛青花,为爵床科马蓝属植物马蓝、蓼科蓼属植物蓼蓝、豆科木蓝属植物木蓝、十字花科菘蓝属植物菘蓝的叶或茎叶经加工制得的干燥粉末或团块。药性:本品为深蓝色的粉末,体轻,易飞扬,微有草腥气,味咸,性寒。成分:其主要成分有靛玉红,靛蓝。根据现代药理研究发现,该药具有抗肿瘤、抗炎镇痛、抗溃疡、抗菌、清热凉血、解毒的功效,用于温毒斑疹,咽喉肿痛,吐血,衄血,咯血等症状。
甘草:甘草还有抗炎,抗过敏作用,能保护发炎的咽喉和气管粘膜。甘草浸膏和甘草酸对某些毒物有类似葡萄糖醛酸的解毒作用。甘草常用来治疗随更年期而来的症状.因为甘草里含有甘草素,是一种类似激素的化合物,它有助于平衡女性体内的激素含量。
炉甘石:为碳酸盐类方解石族矿物菱锌矿或碳酸盐类矿物水锌矿。成分:1.炉甘石主要陈为碳酸锌,尚含少量氧化钙0.27%,氧化镁0.45%,氧化铁0.58%,氧化锰0.01%。其中锌往往为少量的铁(二价)所取代。有的尚含少量钴、铜、镉、铅等。2.浮水甘石主要成分为碱式碳酸锌,并含铅、镉、镁、铁、铝等杂志。药性:甘,平。归肝、脾、肺经。功用主治:明目去翳,收湿止痒,敛疮生肌。主治目赤肿痛,烂弦风眼,多泪畏光,翳膜胬肉,溃疡不敛,皮肤湿疹,阴部湿痒。
本发明组合物制剂符合中医中药辩症治疗的原理,选用的药材分可用于口服和外用,内外同时施治,治疗更加全面,病灶处给药更加迅速,药效持久,属于内外兼顾,标本兼治的小儿手足口病组方,对小儿手足口病有极好的治疗作用。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案,但保护范围不被此限制。
实施例一:治疗小儿手足口病的组合物制剂,取下述重量配比的主要原料制备而成(每份取10g):白鲜皮3份,蚤休15份,花椒10份,薄荷3份,金银花3份,艾叶15份,半枝莲15份,野菊花10份,土荆皮10份,百合5份,青蒿3份,红景天3份,青黛15份,甘草10份,炉甘石1份。
所述的组合物制剂的制备方法,步骤如下:
①将花椒和薄荷打碎用温水浸泡30分钟,用武火烧开后通入水蒸气蒸馏50分钟,使挥发油与水一同蒸馏出来,收集蒸馏液,静置1小时,馏液冷却至室温,取上层油液待用。
②将白鲜皮、蚤休和金银花用苦瓜汁拌匀,苦瓜汁是白鲜皮、蚤休和金银花用量的2倍,浸泡1小时,取出烘制酥脆,研磨成细末待用;
③将炉甘石置于无烟的炉火上,锻制酥脆,研磨成细末,过100目筛待用;
④将艾叶、半枝莲、野菊花、土荆皮、百合、青蒿、红景天和甘草加水煎煮两次,每次都是先大火煮沸,在转文火煎煮20分钟,两次滤液混匀,置于砂锅内,加入步骤②、③所得物和青黛,一边搅拌一边煎煮5分钟,过滤,滤液静置5小时,得上清液,将步骤①所得油液与上清液混匀,装瓶后上下左右各摇晃15下即得。
典型案例一:王XX,男,3岁,山东济宁金乡人,患者父亲叙述说:他孩子所在的幼儿园有1/3的孩子出现了手足口病的症状,5天天,孩子说全身难受,咽痛的厉害,手脚有出现疱疹,瘙痒明显,并伴有灼热感,孩子一直哭,家人带孩子去医院检查,在金乡某医院诊断为夏季皮炎,并开了一些抗组胺类内服药和止痒软膏外用,起初症状减缓,停药后一天上述症状又出现了,去医院确诊为小儿手足口病,医生强烈建议使用本发明组合物制剂。
使用本发明实施例1所得组合物制剂,先将患处洗干净,用毛巾擦干,将本发明组合物制剂喷于患处,一日数次,每次适量,内服时,将本发明组合物制剂喷于嘴内,每次喷2-5下,一日数次,使用1天后症状好转,咽痛症状消失,疱疹变软了,继续使用3天以后患者自感治愈。
实施例二:治疗小儿手足口病的组合物制剂,取下述重量配比的主要原料制备而成(每份取10g):白鲜皮5份,蚤休16份,花椒15份,薄荷4份,金银花4份,艾叶18份,半枝莲18份,野菊花12份,土荆皮14份,百合6份,青蒿3.5份,红景天6份,青黛20份,甘草15份,炉甘石1.5份。
所述的组合物制剂的制备方法,步骤如下
①将花椒和薄荷打碎用温水浸泡50分钟,用武火烧开后通入水蒸气蒸馏70分钟,使挥发油与水一同蒸馏出来,收集蒸馏液,静置3小时,馏液冷却至室温,取上层油液待用。
②将白鲜皮、蚤休和金银花用苦瓜汁拌匀,苦瓜汁是白鲜皮、蚤休和金银花用量的4倍,浸泡1-3小时,取出烘制酥脆,研磨成细末待用;
③将炉甘石置于无烟的炉火上,锻制酥脆,研磨成细末,过140目筛待用;
④将艾叶、半枝莲、野菊花、土荆皮、百合、青蒿、红景天和甘草加水煎煮两次,每次都是先大火煮沸,在转文火煎煮40分钟,两次滤液混匀,置于砂锅内,加入步骤②、③所得物和青黛,一边搅拌一边煎煮15分钟,过滤,滤液静置10小时,得上清液,将步骤①所得油液与上清液混匀,装瓶后上下左右各摇晃15下即得。
实施例三:治疗小儿手足口病的组合物制剂,取下述重量配比的主要原料制备而成(每份取10g):白鲜皮9份,蚤休25份,花椒25份,薄荷8份,金银花8份,艾叶28份,半枝莲25份,野菊花18份,土荆皮18份,百合8份,青蒿5份,红景天14份,青黛38份,甘草28份,炉甘石2.5份。
①将花椒和薄荷打碎用温水浸泡35分钟,用武火烧开后通入水蒸气蒸馏55分钟,使挥发油与水一同蒸馏出来,收集蒸馏液,静置1.5小时,馏液冷却至室温,取上层油液待用。
②将白鲜皮、蚤休和金银花用苦瓜汁拌匀,苦瓜汁是白鲜皮、蚤休和金银花用量的2.5倍,浸泡1.5小时,取出烘制酥脆,研磨成细末待用;
③将炉甘石置于无烟的炉火上,锻制酥脆,研磨成细末,过110目筛待用;
④将艾叶、半枝莲、野菊花、土荆皮、百合、青蒿、红景天和甘草加水煎煮两次,每次都是先大火煮沸,在转文火煎煮25分钟,两次滤液混匀,置于砂锅内,加入步骤②、③所得物和青黛,一边搅拌一边煎煮8分钟,过滤,滤液静置6小时,得上清液,将步骤①所得油液与上清液混匀,装瓶后上下左右各摇晃15下即得。
实施例四:治疗小儿手足口病的组合物制剂,取下述重量配比的主要原料制备而成(每份取10g):白鲜皮9份,蚤休30份,花椒30份,薄荷9份,金银花10份,艾叶30份,半枝莲30份,野菊花20份,土荆皮20份,百合9份,青蒿6份,红景天15份,青黛40份,甘草10-30份,炉甘石3份。
①将花椒和薄荷打碎用温水浸泡45分钟,用武火烧开后通入水蒸气蒸馏65分钟,使挥发油与水一同蒸馏出来,收集蒸馏液,静置2.5小时,馏液冷却至室温,取上层油液待用。
②将白鲜皮、蚤休和金银花用苦瓜汁拌匀,苦瓜汁是白鲜皮、蚤休和金银花用量的3.5倍,浸泡2.5小时,取出烘制酥脆,研磨成细末待用;
③将炉甘石置于无烟的炉火上,锻制酥脆,研磨成细末,过130目筛待用;
④将艾叶、半枝莲、野菊花、土荆皮、百合、青蒿、红景天和甘草加水煎煮两次,每次都是先大火煮沸,在转文火煎煮35分钟,两次滤液混匀,置于砂锅内,加入步骤②、③所得物和青黛,一边搅拌一边煎煮13分钟,过滤,滤液静置9小时,得上清液,将步骤①所得油液与上清液混匀,装瓶后上下左右各摇晃15下即得。
典型病例二:邹XX,女,2岁,济宁人士,于2011年6月开始,面部、腋窝及大腿内侧皮肤上有小疱疹,咽干咽痛,还轻微的咳嗽,导致孩子一点精神都没有,一直哭,服用抗组胺药后症状无明显变化,不仅如此小疱疹有的破裂,非常的疼痛,得知本发明组合物制剂后来我处就诊。
使用本实施例4所得缓解小儿手足口病的组合物制剂,先将患处洗干净,用毛巾擦干,将本发明组合物制剂喷于患处,一日数次,每次适量,内服时,将本发明组合物制剂喷于嘴内,每次喷5下,一日数次,使用2天,咽痛,咳嗽等症状消失,破裂的疱疹愈合了,继续使用一个疗程,患者自感痊愈,至今未复发。
实施例五:治疗小儿手足口病的组合物制剂,取下述重量配比的主要原料制备而成(每份取10g):白鲜皮8份,蚤休20份,花椒20份,薄荷6份,金银花5份,艾叶20份,半枝莲20份,野菊花15份,土荆皮15份,百合7份,青蒿4份,红景天12份,青黛30份,甘草25份,炉甘石2份。
①将花椒和薄荷打碎用温水浸泡40分钟,用武火烧开后通入水蒸气蒸馏60分钟,使挥发油与水一同蒸馏出来,收集蒸馏液,静置2小时,馏液冷却至室温,取上层油液待用。
②将白鲜皮、蚤休和金银花用苦瓜汁拌匀,苦瓜汁是白鲜皮、蚤休和金银花用量的3倍,浸泡2小时,取出烘制酥脆,研磨成细末待用;
③将炉甘石置于无烟的炉火上,锻制酥脆,研磨成细末,过120目筛待用;
④将艾叶、半枝莲、野菊花、土荆皮、百合、青蒿、红景天和甘草加水煎煮两次,每次都是先大火煮沸,在转文火煎煮30分钟,两次滤液混匀,置于砂锅内,加入步骤②、③所得物和青黛,一边搅拌一边煎煮10分钟,过滤,滤液静置7.5小时,得上清液,将步骤①所得油液与上清液混匀,装瓶后上下左右各摇晃15下即得。
实验例1:为了验证本发明组合物制剂的效果,我们进行了药物的实验,并精确的对数据进行了统计和数理分析。
具体实验结果如下表:(实施例5所得中药)
表1:
表2:
经临床试验证明,使用本发明组合物制剂与西医治疗小儿手足口病的手段相比,治愈后复发率低,治疗手段更为全面彻底,使用期间无副作用,在治疗小儿手足口病的同时,可以缓解由小儿手足口病引起的红肿、瘙痒和疱疹等症状,经临床试验证明,本发明中药药剂有效率为99%,因此本发明组合物制剂是一种安全有效的治疗小儿手足口病的药物。
Claims (10)
1.一种治疗小儿手足口病的组合物制剂,其特征在于:取下述重量配比的主要原料制备而成:白鲜皮3-9份,蚤休15-30份,花椒10-30份(优选的,花椒10.5-29.5份),薄荷3-9份,金银花3-10份,艾叶15-30份,半枝莲15-30份,野菊花10-20份,土荆皮10-20份,百合5-9份,青蒿3-6份,红景天3-15份,青黛15-40份,甘草10-30份,炉甘石1-3份。
2.根据权利要求1所述的治疗小儿手足口病的组合物制剂,其特征在于:取下述重量配比的主要原料制备而成:白鲜皮5-9份,蚤休16-25份,花椒15-25份,薄荷4-8份,金银花4-8份,艾叶18-28份,半枝莲18-25份,野菊花12-18份,土荆皮14-18份,百合6-8份,青蒿3.5-5份,红景天6-14份,青黛20-38份,甘草15-28份,炉甘石1.5-2.5份。
3.根据权利要求1所述的治疗小儿手足口病的组合物制剂,其特征在于:取下述重量配比的主要原料制备而成:白鲜皮8份,蚤休20份,花椒20份,薄荷6份,金银花5份,艾叶20份,半枝莲20份,野菊花15份,土荆皮15份,百合7份,青蒿4份,红景天12份,青黛30份,甘草25份,炉甘石2份。
4.根据权利要求1-3任一项所述的治疗小儿手足口病的组合物制剂的制备方法,其特征在于:步骤如下:
花椒和薄荷打碎用温水浸泡30-50分钟,用武火烧开后通入水蒸气蒸馏50-70分钟,使挥发油与水一同蒸馏出来,收集蒸馏液,静置1-3小时,馏液冷却至室温,取上层油液待用;
②将白鲜皮、蚤休和金银花用苦瓜汁拌匀,苦瓜汁是白鲜皮、蚤休和金银花用量的2-4倍,浸泡1-3小时,取出烘制酥脆,研磨成细末待用;
③将炉甘石置于无烟的炉火上,锻制酥脆,研磨成细末,过100-140目筛待用;
④将艾叶、半枝莲、野菊花、土荆皮、百合、青蒿、红景天和甘草加水煎煮两次,每次都是先大火煮沸,在转文火煎煮20-40分钟,两次滤液混匀,置于砂锅内,加入步骤②、③所得物和青黛,一边搅拌一边煎煮5-15分钟,过滤,滤液静置5-10小时,得上清液,将步骤①所得油液与上清液混匀,装瓶后上下左右各摇晃15下即得。
5.根据权利要求4所述的组合物制剂的制备方法,其特征在于:步骤①将花椒和薄荷打碎用温水浸泡35-45分钟,用武火烧开后通入水蒸气蒸馏55-65分钟(优选的,将花椒和薄荷打碎用温水浸泡40分钟,用武火烧开后通入水蒸气蒸馏60分钟)。
6.根据权利要求4所述的组合物制剂的制备方法,其特征在于:步骤①收集蒸馏液,静置1.5-2.5小时(优选的,收集蒸馏液,静置2小时)。
7.根据权利要求4所述的组合物制剂的制备方法,其特征在于:步骤②苦瓜汁是白鲜皮、蚤休和金银花用量的2.5-3.5倍,浸泡1.5-2.5小时(优选的,苦瓜汁是白鲜皮、蚤休和金银花用量的3倍,浸泡2小时)。
8.根据权利要求4所述的组合物制剂的制备方法,其特征在于:步骤③细末过110-130目筛待用(优选的,细末过120目筛待用)。
9.根据权利要求4所述的组合物制剂的制备方法,其特征在于:步骤④在转文火煎煮25-35分钟(优选的,在转文火煎煮30分钟)。
10.根据权利要求4所述的组合物制剂的制备方法,其特征在于:步骤④一边搅拌一边煎煮8-13分钟,过滤,滤液静置6-9小时(优选的,一边搅拌一边煎煮10分钟,过滤,滤液静置7.5小时)。
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