CN105079153A - Manufacturing method of compound sponge capable of eliminating swelling caused by extravasation of coronal artery angiography agent - Google Patents
Manufacturing method of compound sponge capable of eliminating swelling caused by extravasation of coronal artery angiography agent Download PDFInfo
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Abstract
The invention discloses compound sponge capable of eliminating swelling caused by extravasation of coronal artery angiography agent. The compound sponge is prepared from the following main active ingredients in parts by weight: 3-9 parts of circium japonicum, 12-20 parts of starch, 2-4 parts of root of sungpan monkshood, 4-8 parts of root of scutellaria baicalensis, and 100-130 parts of water for injection. According to the compound sponge capable of eliminating swelling caused by extravasation of coronal artery angiography agent, the raw materials are low in price and safe and effective, the compound sponge is developed on the basis of the study on large quantity of pharmacopeia data and clinical tests and aiming at extravasation of the coronal artery angiography agent, is significant in effect, and free of any toxic and side effects.
Description
divisional application, original applying number 2014104066807, applying date 2014.08.19, title is eliminated coronal artery angiography agent and to be exosmosed the compound recipe sponge of caused swelling and preparation method.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to and a kind ofly eliminate coronal artery angiography agent and to exosmose the compound recipe sponge of caused swelling and preparation method.
Background technology
Coronary atherosclerotic heart disease (hereinafter referred to as coronary heart disease) causes the heart disease caused by myocardial ischemia, anoxia due to selenium shape atherosclerosis.And more than 95% myocardial infarction is many is formed by developing coronary heart disease, and acute myocardial infarction mortality rate is very high, mostly 30% ~ 40%, is serious threat human life, healthy commonly encountered diseases.
Current coronarography is that the one of diagnosis of coronary heart disease is commonly used and effective method, is considered to " goldstandard " of diagnosis of coronary heart disease.Selective coronary arteriography utilizes angiography machine exactly, enter lower limb femoral artery by the cardiac catheter percutaneous puncture of special sizing, drive in the wrong direction to root of ascending aorta along descending aorta, then seek left or right coronary ostium and insert, inject contrast agent, coronary artery is developed.So just can clearly the lumen of vessels of trunk coronarius for whole left or right and branch thereof be shown, blood vessel can be understood exist with or without stenotic lesions, the situation etc. of diseased region, scope, the order of severity, blood vessel wall is made and clarifies a diagnosis, determine therapeutic scheme (get involved, perform the operation or medical treatment), also can be used to judge curative effect.This is that one is safer wound diagnostic techniques reliably, has now been widely used in clinical, has been considered to " goldstandard " of diagnosis of coronary heart disease.Coronarography has important clinical meaning: (1) clear and definite diagnosis of coronary heart disease: for there being atypical angina pectoris symptom, clinical being difficult to makes a definite diagnosis, especially therapeutic effect gastrointestinal disease patient, and old and middle-aged patients cardiac dilatation, severe arrhythmia, heart failure, electrocardiographic abnormality, suspect have coronary artery pathological changes or deformity, but noninvasive test result can not the person of making a definite diagnosis, and coronarography can provide strong diagnosis basis.(2) treatment is used to guide: to the patients with coronary heart disease confirmed clinically, internal medicine conservative treatment is not good, consideration adopts percutaneous tranluminal coronary angioplasty, (PTCA) or ACBG art time, first must carry out coronary artery and ventriculography of left ventricle, specify the function situation of the position of coronary stricture, degree and left ventricle, with selecting properly indication, formulate therapeutic scheme.For limbs obesity, edema, Keratoderma, Pigmented patient, often need repeated localised puncture, therefore may injured blood vessel wall.In addition need vasopressing injection, venous pressure is significantly increased, more easily cause contrast agent seepage.To high-risk group as the patients such as long-term chemotherapy, old sclerosis of blood vessels, obesity carry out enhanced ct scans time, the probability of extravasation of contrast media is relatively high, should attract great attention.Contrast agent viscosity is large, osmotic pressure is high, strong to subcutaneous tissue zest after exosmosing, and tissue local compressing swelling occurs, hurt like hell.
Authorize publication number CN102366438A(application number 201110327722.4) Chinese patent literature disclose a kind of " a kind of external application Chinese medicine eliminating swelling and preparation method thereof " by name, it is made up of Fructus Arctii, Borneolum Syntheticum, Herba Menthae, Lasiosphaera Seu Calvatia and Radix Glycyrrhizae.Authorize publication number CN103585273A(application number 201310488640.7) Chinese patent literature disclose a kind of " a kind of Chinese medicine composition being used for the treatment of local swelling, pain " by name, it is made up of the Radix Euphorbiae Pekinensis, Radix Kansui, Semen Sinapis Albae, Moschus, Herba Ephedrae, Pheretima, Ramulus Cinnamomi, Semen Strychni and Stalactitum.Authorize publication number CN103933202A(application number 201410128900.4) Chinese patent literature disclose a kind of " Chinese herbal medicine of a kind of reducing swelling and alleviating pain and preparation method thereof " by name, its by: Radix Rehmanniae juice, Chinese liquor, Cortex Moutan, Cortex Cinnamomi, Semen Persicae, Moschus forms.
Clinically, when contrast agent exosmoses, positive remedy measures elimination tissue edema and medicine should be taked cytotoxic effect.General employing hot compress, cold compress, wet packing of drugs method and antagonist facture.These methods achieve certain effect in elimination contrast agent exosmoses caused swelling, but also there are some problems: not yet develop at present and be directed to heart arteria coronaria contrast agent and exosmose the medicine of caused swelling, and in the medicine of existing elimination swelling, effect for swelling position is slow, effect is undesirable, needs to be improved further.
Summary of the invention
In order to make up above-mentioned deficiency, the object of the present invention is to provide and a kind ofly eliminate coronal artery angiography agent and to exosmose the compound recipe sponge and preparation method thereof of caused swelling, have cost low, prepare the advantages such as simple, and to exosmose caused swelling development and going out for coronal artery angiography agent specially, haemostatic effect is very remarkable.
Technical scheme of the present invention is:
The compound recipe sponge that caused swelling is exosmosed in the agent of elimination coronal artery angiography, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Cirsii Japonici 3-9 part (preferred, Radix Cirsii Japonici 3.2-8.5 part; Be more preferably, Radix Cirsii Japonici 6.2 parts), starch 12-20 part, Radix Aconiti Sungpanensis 2-4 part, Radix Scutellariae 4-8 part, water for injection 100-130 part.
Eliminate coronal artery angiography agent to exosmose the compound recipe sponge of caused swelling, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Cirsii Japonici 4-8 part, starch 14-18 part, Radix Aconiti Sungpanensis 2.5-3.5 part, Radix Scutellariae 5-7 part, water for injection 110-120 part.
Eliminate coronal artery angiography agent to exosmose the compound recipe sponge of caused swelling, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Cirsii Japonici 6 parts, starch 16 parts, Radix Aconiti Sungpanensis 3 parts, Radix Scutellariae 6 parts, water for injection 115 parts.
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and step is as follows:
(1) Radix Cirsii Japonici of drying is ground to form smalls, cross 80-120 mesh sieve;
(2) step (1) gained Radix Cirsii Japonici, Radix Scutellariae and Radix Aconiti Sungpanensis are together placed in terrine, heating water is dipped to water temperature when being 30-40 DEG C, is placed in by terrine on tile, big fire decocts 2 hours, turns low baking temperature and simmers 30 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(3) by water for injection and starch mix homogeneously, put in water-bath and heat, add step (2) gained filtrate, constantly stir, treat that it becomes the pastel of homogeneous transparent, be cooled to room temperature, then freezing;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 65% 0.5 hour, and second time to immerse in the ethanol of 75% 1 hour, third time immerse take out after 1.5 days in the ethanol of 95% stand-by;
(6) ethanol in removing step (5) gained fritter, dry, obturage with paper wrapper, in 130 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and preferred scheme is, step (2) heating water soaks, and temperature is 80-100 DEG C, and (preferred, temperature is 85-95 DEG C; Be more preferably, temperature is 90 DEG C).
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and preferred scheme is, in step (2), the temperature of water-bath is 65-85 DEG C (preferred, temperature is 70-80 DEG C; Be more preferably, temperature is 75 DEG C).
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and preferred scheme is, the freezing temperature of step (3) is-30-1 DEG C, and (preferred, freezing temperature is-20--10 DEG C; Be more preferably, freezing temperature is-15 DEG C).
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and preferred scheme is, step (3) freezing time is that (preferred, the freezing time was 7-9 hour in 6-10 hour; Be more preferably, the freezing time is 8 hours).
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and preferred scheme is, the dry temperature of step (6) is 30-50 DEG C, and (preferred, dry temperature is 35-45 DEG C; Be more preferably, dry temperature is 40 DEG C).
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and preferred scheme is, the time of step (6) dry heat sterilization is that (preferred, the time of dry heat sterilization was 1.5-2.5 hour in 1.0-3.0 hour; Be more preferably, the time of dry heat sterilization is 2 hours).
Using method: when coronal artery angiography agent is exosmosed and caused skin turgor, gets one piece of compound recipe sponge and directly applies at swelling position.
The pharmacological effect of each crude drug is respectively:
Radix Cirsii Japonici: base is former: this product is the dry aerial parts of feverfew Ji CirsiumjaponicumFisch.exDC..Summer, autumn two tap aerial parts when season, the flowers are in blossom, and removing impurity, dries.Nature and flavor: sweet, bitter, cold.Gui Jing: GUIXIN, Liver Channel.Effect: cooling blood for hemostasis, removing blood stasis to reduce swelling.Cure mainly: for epistaxis. spit blood. hematuria, have blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Radix Aconiti Sungpanensis: base is former: be the root of Ranunculaceae aconitum plant Aconitum Sungpanense Hand-mazz.Composition: talaisamine, chasmanine, vilmorrianine A.Pharmacology: antiinflammatory, the refrigeration function property of medicine: pungent, bitter, heat, large malicious function cures mainly: expelling wind and dampness, dispersing cold for relieving pain, dissipating blood stasis for subsidence of swelling.Cure mainly anemofrigid-damp arthralgia, arthrodynia of extremities, toothache, traumatic injury, carbuncle skin infection, neuralgia.
Radix Scutellariae: base is former: this product is the dry root of labiate Radix Scutellariae ScutellariabaicalensisGeorgi.Nature and flavor: bitter, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, rushes down people's removing toxic substances, hemostasis, antiabortive.Cure mainly: for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Water for injection: the water that water for injection specifies under referring to meet Chinese Pharmacopoeia water for injection item.Water for injection be distilled water or deionization through distilling the water of gained, therefore also known as double distilled water.The preparation of water for injection, storage and distribution should be able to prevent growing of microorganism and pollute.Basin and conveyance conduit material therefor should be nontoxic, corrosion-resistant.The design and installation of pipeline should avoid dead angle, blind pipe.Basin and pipeline will specify cleaning, sterilising cycle.The blow vent of injection water storage tank should install the hydrophobicity germ tight filter of the fiber that do not come off.The storage of water for injection can adopt more than 80 DEG C insulations, more than 70 DEG C soak cycles or less than 4 DEG C are deposited.Pharmacological action: solvent.
Starch: white powder; Odorless, tasteless.All do not dissolve in cold water or ethanol.Starch has amylose and amylopectin two class.Amylose is containing a hundreds of glucose unit, and amylopectin is containing several thousand glucose units.In native starch straight chain account for 20% ~ 26%, it is solubility, and remaining is then amylopectin.When detecting with iodine solution, amylose liquid manifests blueness, then becomes rufous when amylopectin contacts with iodine.When detecting with iodine solution, amylose liquid manifests blueness, then becomes rufous when amylopectin contacts with iodine.Chemical composition: the polysaccharide granule that this strain is obtained in the tuber of the zeistic caryopsis of grass or euphorbia plant Maninot esculenta crantz..Pharmacological action: pharmaceutic adjuvant, excipient.
A kind of trauma hemostasis of the present invention is cheap, safe and effective with raw material selected by Radix Sanguisorbae sponge, is develop specially for internal hemorrhoid operative hemorrhage on the basis that have studied a large amount of pharmacopeia data and clinical trial, Be very effective and without any side effects.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1the compound recipe sponge that caused swelling is exosmosed in the agent of elimination coronal artery angiography, takes off the primary raw material medicine stating weight proportion and is prepared from (getting 25g for every part): Radix Cirsii Japonici 3 parts, starch 12 parts, Radix Aconiti Sungpanensis 2 parts, Radix Scutellariae 4 parts, water for injection 100 parts.
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and step is as follows:
(1) Radix Cirsii Japonici of drying is ground to form smalls, cross 80-120 mesh sieve;
(2) step (1) gained Radix Cirsii Japonici, Radix Scutellariae and Radix Aconiti Sungpanensis are together placed in terrine, when to add 80 DEG C of hot-water soaks to water temperature be 30-40 DEG C, terrine are placed on tile, big fire decocts 2 hours, turns low baking temperature and simmers 30 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(3) by water for injection and starch mix homogeneously, put in water-bath and be heated to 65 DEG C, add step (2) gained filtrate, constantly stir, treat that it becomes the pastel of homogeneous transparent, be cooled to room temperature, then at-30 DEG C freezing 6 hours;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 65% 0.5 hour, and second time to immerse in the ethanol of 75% 1 hour, third time immerse take out after 1.5 days in the ethanol of 95% stand-by;
(6) ethanol in removing step (5) gained fritter, in 30 DEG C of dryings, obturages with paper wrapper, in 130 DEG C of dry heat sterilizations 1.0 hours, is sealed in plastic bag, obtains final product.
Using method: when coronal artery angiography agent is exosmosed and caused skin turgor, gets one piece of compound recipe sponge and directly applies at swelling position.
model case one: Lee XX, female, 66 years old, main suit: vexed pain after breastbone, in persistence, the radiation of companion's back part, without abdominal distention, without stomachache, without nausea and vomiting, without fear of cold heating, without cough and expectoration.Admission examination is diagnosed as " angina pectoris unknown origin ".For making a definite diagnosis further, through doctor and patient by mutual consent, underwent coronary CTA checks.Check latter 30 minutes, there is swelling in patient's left upper extremity, has an intense pain, subsequently swelling gradually, red swelling of the skin, and next day, patient's left upper extremity the back of the hand occurred damaged, had sepage to flow out.Then use 50% magnesium sulfate dressing, symptom not be improved significantly.Use the present embodiment 1 gained to eliminate coronal artery angiography agent to exosmose the compound recipe sponge of caused swelling, getting one piece of compound recipe sponge directly applies at swelling position, after 40 minutes, skin color is tending towards normal, next day, and left upper extremity swelling is disappeared, the outer most of wound surface of arm breakage is formed a scab, liquid body exudate is few, and freely, indices is all normal in right upper extremity activity.
embodiment 2the compound recipe sponge that caused swelling is exosmosed in the agent of elimination coronal artery angiography, takes off the primary raw material medicine stating weight proportion and is prepared from (getting 20g for every part): Radix Cirsii Japonici 9 parts, starch 20 parts, Radix Aconiti Sungpanensis 4 parts, Radix Scutellariae 8 parts, water for injection 130 parts.
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and step is as follows:
(1) Radix Cirsii Japonici of drying is ground to form smalls, cross 80-120 mesh sieve;
(2) step (1) gained Radix Cirsii Japonici, Radix Scutellariae and Radix Aconiti Sungpanensis are together placed in terrine, when to add 100 DEG C of hot-water soaks to water temperature be 30-40 DEG C, terrine are placed on tile, big fire decocts 2 hours, turns low baking temperature and simmers 30 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(3) by water for injection and starch mix homogeneously, put in water-bath and be heated to 85 DEG C, add step (2) gained filtrate, constantly stir, treat that it becomes the pastel of homogeneous transparent, be cooled to room temperature, then at 1 DEG C freezing 10 hours;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 65% 0.5 hour, and second time to immerse in the ethanol of 75% 1 hour, third time immerse take out after 1.5 days in the ethanol of 95% stand-by;
(6) ethanol in removing step (5) gained fritter, in 50 DEG C of dryings, obturages with paper wrapper, in 130 DEG C of dry heat sterilizations 3.0 hours, is sealed in plastic bag, obtains final product.
Using method: when coronal artery angiography agent is exosmosed and caused skin turgor, gets one piece of compound recipe sponge and directly applies at swelling position.
embodiment 3the compound recipe sponge that caused swelling is exosmosed in the agent of elimination coronal artery angiography, takes off the primary raw material medicine stating weight proportion and is prepared from (getting 20g for every part): Radix Cirsii Japonici 4 parts, starch 14 parts, Radix Aconiti Sungpanensis 2.5 parts, Radix Scutellariae 5 parts, water for injection 110 parts.
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and step is as follows:
(1) Radix Cirsii Japonici of drying is ground to form smalls, cross 80-120 mesh sieve;
(2) step (1) gained Radix Cirsii Japonici, Radix Scutellariae and Radix Aconiti Sungpanensis are together placed in terrine, when to add 85 DEG C of hot-water soaks to water temperature be 30-40 DEG C, terrine are placed on tile, big fire decocts 2 hours, turns low baking temperature and simmers 30 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(3) by water for injection and starch mix homogeneously, put in water-bath and be heated to 70 DEG C, add step (2) gained filtrate, constantly stir, treat that it becomes the pastel of homogeneous transparent, be cooled to room temperature, then at-20 DEG C freezing 7 hours;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 65% 0.5 hour, and second time to immerse in the ethanol of 75% 1 hour, third time immerse take out after 1.5 days in the ethanol of 95% stand-by;
(6) ethanol in removing step (5) gained fritter, in 35 DEG C of dryings, obturages with paper wrapper, in 130 DEG C of dry heat sterilizations 1.5 hours, is sealed in plastic bag, obtains final product.
Using method: when coronal artery angiography agent is exosmosed and caused skin turgor, gets one piece of compound recipe sponge and directly applies at swelling position.
embodiment 4the compound recipe sponge that caused swelling is exosmosed in the agent of elimination coronal artery angiography, takes off the primary raw material medicine stating weight proportion and is prepared from (getting 25g for every part): Radix Cirsii Japonici 8 parts, starch 18 parts, Radix Aconiti Sungpanensis 3.5 parts, Radix Scutellariae 7 parts, water for injection 120 parts.
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and step is as follows:
(1) Radix Cirsii Japonici of drying is ground to form smalls, cross 80-120 mesh sieve;
(2) step (1) gained Radix Cirsii Japonici, Radix Scutellariae and Radix Aconiti Sungpanensis are together placed in terrine, when to add 95 DEG C of hot-water soaks to water temperature be 30-40 DEG C, terrine are placed on tile, big fire decocts 2 hours, turns low baking temperature and simmers 30 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(3) by water for injection and starch mix homogeneously, put in water-bath and be heated to 80 DEG C, add step (2) gained filtrate, constantly stir, treat that it becomes the pastel of homogeneous transparent, be cooled to room temperature, then at-10 DEG C freezing 9 hours;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 65% 0.5 hour, and second time to immerse in the ethanol of 75% 1 hour, third time immerse take out after 1.5 days in the ethanol of 95% stand-by;
(6) ethanol in removing step (5) gained fritter, in 45 DEG C of dryings, obturages with paper wrapper, in 130 DEG C of dry heat sterilizations 2.5 hours, is sealed in plastic bag, obtains final product.
Using method: when coronal artery angiography agent is exosmosed and caused skin turgor, gets one piece of compound recipe sponge and directly applies at swelling position.
model case two: high XX, man, 59 years old, main suit: tachypnea, nocturnal paroxysmal dyspnea appear suddenly in a period of time, without episode, patient has the various arrhythmia symptoms such as atrial fibrillation, room morning, atrioventricular block on inspection, is clinically referred to as " arrhythmia and heart failure type coronary heart disease ".For making a definite diagnosis further, agree to, through the capable coronary arteriography of right radial artery through patient.Piercing method: routine disinfection, drape, selects right side radial artery, and point of puncture is apart from carpal joint 2-4cm, and after local anesthesia, get the puncture of arterial pulsation point of maximum intensity, inserting needle direction is consistent with radial artery traveling.After 5 hours, the swelling of patient forearm's palmar, hardening, have an intense pain, develop into subcutaneous extvavasated blood subsequently, caused by extravasation of contrast media.Conventional detumescence method symptom is adopted not to be eased.Use the present embodiment 4 gained to eliminate coronal artery angiography agent to exosmose the compound recipe sponge of caused swelling, get compound recipe sponge and directly apply at swelling position, 45 minutes, skin turgor is alleviated, and pain alleviates; Next day, swelling was all disappeared, and pressing is without pain, and subcutaneous extvavasated blood disappears.
embodiment 5the compound recipe sponge that caused swelling is exosmosed in the agent of elimination coronal artery angiography, takes off the primary raw material medicine stating weight proportion and is prepared from (getting 25g for every part): Radix Cirsii Japonici 6 parts, starch 16 parts, Radix Aconiti Sungpanensis 3 parts, Radix Scutellariae 6 parts, water for injection 115 parts.
The agent of above-mentioned elimination coronal artery angiography is exosmosed the preparation method of compound recipe sponge of caused swelling, and step is as follows:
(1) Radix Cirsii Japonici of drying is ground to form smalls, cross 80-120 mesh sieve;
(2) step (1) gained Radix Cirsii Japonici, Radix Scutellariae and Radix Aconiti Sungpanensis are together placed in terrine, when to add 90 DEG C of hot-water soaks to water temperature be 30-40 DEG C, terrine are placed on tile, big fire decocts 2 hours, turns low baking temperature and simmers 30 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(3) by water for injection and starch mix homogeneously, put in water-bath and be heated to 75 DEG C, add step (2) gained filtrate, constantly stir, treat that it becomes the pastel of homogeneous transparent, be cooled to room temperature, then at-15 DEG C freezing 8 hours;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 65% 0.5 hour, and second time to immerse in the ethanol of 75% 1 hour, third time immerse take out after 1.5 days in the ethanol of 95% stand-by;
(6) ethanol in removing step (5) gained fritter, in 40 DEG C of dryings, obturages with paper wrapper, in 130 DEG C of dry heat sterilizations 2 hours, is sealed in plastic bag, obtains final product.
Using method: when coronal artery angiography agent is exosmosed and caused skin turgor, gets one piece of compound recipe sponge and directly applies at swelling position.
experimental example 1embodiment 5 gained is eliminated coronal artery angiography agent and to be exosmosed the clinical practice of compound recipe sponge of caused swelling: in May ,-2013 in July, 2009, screen 73 routine coronal artery angiography art patients in 9 hospitals.Patients is: the surrounding of point of puncture or forearm swelling, and the pain touched can be stood.All patients are divided into two groups at random, experimental group and matched group, and experimental group uses the present embodiment 5 products obtained therefrom, and matched group uses other detumescences medicine (as dexamethasone, ruyi jinhuang powder, ruyi jinhuang san, 50% magnesium sulfate etc.).Using method: get compound recipe sponge and directly apply at swelling position.Curative effect situation criterion: recovery from illness: skin turgor disappears completely, color is normal, and pressing is without pain.Effective: skin turgor disappears substantially, there is slight tenderness sense; Invalid: symptom and sign is without improvement.Result is as shown in table 1.
Table 1: embodiment 5 gained compound recipe sponge compliance test result
Therapeutic effect: cure 39 examples (70.9%), effective 15 examples (27.3%), invalid 1 example (1.8%), total effective rate 98.2%.Successful is better than matched group.
Two groups of onset times and recovery healing time contrast as shown in table 2.
Table 2: two groups of onset times and the contrast of recovery healing time
The present invention selects Radix Scutellariae, Radix Cirsii Japonici and Radix Aconiti Sungpanensis to carry out compatibility, produces synergism after making these drug regimens, can reach reducing swelling and alleviating pain, effect of blood circulation promoting and blood stasis dispelling.Lasting medicine of the present invention, drug effect is rapid, is to eliminate coronal artery angiography agent to exosmose the good medicine of caused swelling.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. eliminate coronal artery angiography agent to exosmose the compound recipe sponge of caused swelling, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Cirsii Japonici 4 parts, starch 14 parts, Radix Aconiti Sungpanensis 2.5 parts, Radix Scutellariae 5 parts, water for injection 110 parts.
2. elimination coronal artery angiography according to claim 1 agent is exosmosed the preparation method of compound recipe sponge of caused swelling, and it is characterized in that, step is as follows:
(1) Radix Cirsii Japonici of drying is ground to form smalls, cross 80-120 mesh sieve;
(2) step (1) gained Radix Cirsii Japonici, Radix Scutellariae and Radix Aconiti Sungpanensis are together placed in terrine, heating water is dipped to water temperature when being 30-40 DEG C, is placed in by terrine on tile, big fire decocts 2 hours, turns low baking temperature and simmers 30 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(3) by water for injection and starch mix homogeneously, put in water-bath and heat, add step (2) gained filtrate, constantly stir, treat that it becomes the pastel of homogeneous transparent, be cooled to room temperature, then freezing;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 65% 0.5 hour, and second time to immerse in the ethanol of 75% 1 hour, third time immerse take out after 1.5 days in the ethanol of 95% stand-by;
(6) ethanol in removing step (5) gained fritter, dry, obturage with paper wrapper, in 130 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
3. preparation method according to claim 2, is characterized in that, step (2) heating water soaks, and temperature is 80-100 DEG C, and (preferred, temperature is 85-95 DEG C; Be more preferably, temperature is 90 DEG C).
4. preparation method according to claim 2, is characterized in that, the temperature of water-bath is 65-85 DEG C (preferred, temperature is 70-80 DEG C in step (2); Be more preferably, temperature is 75 DEG C).
5. preparation method according to claim 2, is characterized in that, the freezing temperature of step (3) is-30-1 DEG C, and (preferred, freezing temperature is-20--10 DEG C; Be more preferably, freezing temperature is-15 DEG C).
6. preparation method according to claim 2, is characterized in that, step (3) freezing time is that (preferred, the freezing time was 7-9 hour in 6-10 hour; Be more preferably, the freezing time is 8 hours).
7. preparation method according to claim 2, is characterized in that, the dry temperature of step (6) is 30-50 DEG C, and (preferred, dry temperature is 35-45 DEG C; Be more preferably, dry temperature is 40 DEG C).
8. preparation method according to claim 2, is characterized in that, the time of step (6) dry heat sterilization is that (preferred, the time of dry heat sterilization was 1.5-2.5 hour in 1.0-3.0 hour; Be more preferably, the time of dry heat sterilization is 2 hours).
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| CN201510571026.6A Pending CN105079153A (en) | 2014-08-19 | 2014-08-19 | Manufacturing method of compound sponge capable of eliminating swelling caused by extravasation of coronal artery angiography agent |
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| Title |
|---|
| 南京中医药大学: "《中药大辞典》", 30 June 2014, 上海科学技术出版社 * |
| 曹春林: "《中药制剂汇编》", 31 October 1983, 人民卫生出版社 * |
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| CN105079152A (en) | 2015-11-25 |
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