CN105073761B - 用于体外和体内成像和检测的取代的硅杂蒽阳离子红至近红外荧光染料 - Google Patents

用于体外和体内成像和检测的取代的硅杂蒽阳离子红至近红外荧光染料 Download PDF

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CN105073761B
CN105073761B CN201480016182.XA CN201480016182A CN105073761B CN 105073761 B CN105073761 B CN 105073761B CN 201480016182 A CN201480016182 A CN 201480016182A CN 105073761 B CN105073761 B CN 105073761B
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CN105073761A (zh
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凯文·格罗夫斯
莱恩·巴福
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Visen Medical Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
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    • A—HUMAN NECESSITIES
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    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0816—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring comprising Si as a ring atom
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    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/28—Pyronines ; Xanthon, thioxanthon, selenoxanthan, telluroxanthon dyes
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    • C09B69/008—Dyes containing a substituent, which contains a silicium atom
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules

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CN201480016182.XA 2013-03-15 2014-03-14 用于体外和体内成像和检测的取代的硅杂蒽阳离子红至近红外荧光染料 Active CN105073761B (zh)

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US201361794188P 2013-03-15 2013-03-15
US61/794,188 2013-03-15
PCT/US2014/029350 WO2014144793A1 (en) 2013-03-15 2014-03-14 Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection

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CN105073761B true CN105073761B (zh) 2020-10-20

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JP (1) JP6606487B2 (enExample)
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AU (1) AU2014228504C1 (enExample)
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Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1934211T3 (en) 2005-09-02 2017-04-10 Visen Medical Inc Biocompatible N, N-disubstituted sulfonamide-containing fluorescent color markers
US9913917B2 (en) 2005-12-22 2018-03-13 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
EP2732826B1 (en) 2008-01-18 2017-11-08 Visen Medical, Inc. Fluorescent imaging agents
EP2707102B1 (en) 2011-05-09 2019-11-13 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
AU2014228504C1 (en) 2013-03-15 2019-10-03 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
CN105339436B (zh) 2013-03-15 2018-05-25 文森医学公司 4,4-二取代环己基桥连七甲川花菁染料及其应用
US9765220B2 (en) 2013-08-22 2017-09-19 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
WO2015083799A1 (ja) * 2013-12-04 2015-06-11 国立大学法人 東京大学 近赤外線消光団
CA2944476C (en) * 2014-04-01 2021-06-15 Howard Hughes Medical Institute Azetidine-substituted fluorescent compounds
CN107454903B (zh) 2015-02-26 2021-01-01 索尼公司 包含共轭基团的水溶性荧光或着色染料
EP3311136B1 (en) * 2015-07-28 2023-06-07 The Regents of The University of California Long wavelength voltage sensitive dyes
JP2017149806A (ja) * 2016-02-22 2017-08-31 富士フイルム株式会社 着色組成物、インクジェット用インク、及び捺染方法
WO2017147015A1 (en) * 2016-02-24 2017-08-31 Saudi Arabian Oil Company Detecting xanthan gum
US11434377B2 (en) 2016-04-01 2022-09-06 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
BR112018070164B1 (pt) 2016-04-01 2022-09-27 Sony Corporation Of America Corantes diméricos ou poliméricos ultrabrilhantes
US9851359B2 (en) 2016-04-06 2017-12-26 Sony Corporation Of America Ultra bright dimeric or polymeric dyes with spacing linker groups
US20190137396A1 (en) * 2016-04-28 2019-05-09 National University Corporation Nagoya University Fluorescent probe, method for detecting fluorescence, and method for using fluorescent probe
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
EP3455238A1 (en) * 2016-05-10 2019-03-20 Sony Corporation Ultra bright polymeric dyes with peptide backbones
BR112018073199A2 (pt) 2016-05-11 2019-04-16 Sony Corporation corantes diméricos ou poliméricos ultrabrilhantes
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
KR20190021340A (ko) * 2016-06-22 2019-03-05 후지필름 와코 준야꾸 가부시키가이샤 규소 함유 복소환식 화합물 및 소광제
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
EP3551034A1 (en) * 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
US20200087516A1 (en) * 2017-02-17 2020-03-19 The University Of Tokyo Red fluorescent probe for use in detection of peptidase activity
KR20200067132A (ko) 2017-10-05 2020-06-11 소니 주식회사 프로그램가능한 중합체성 약물
KR20200064059A (ko) 2017-10-05 2020-06-05 소니 주식회사 프로그램가능한 수지상 약물
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
EP4616912A3 (en) 2018-01-12 2025-11-19 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
CN111565756A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的具有刚性间隔基团的聚合物
EP3769085B1 (en) 2018-03-19 2022-08-24 Sony Group Corporation Use of divalent metals for enhancement of fluorescent signals
KR102864292B1 (ko) 2018-03-21 2025-09-26 소니그룹주식회사 링커 군을 갖는 중합체성 텐덤 염료
US11697736B2 (en) 2018-05-18 2023-07-11 Singular Genomics Systems, Inc. Silicon containing detectable compounds
KR102228538B1 (ko) * 2018-06-01 2021-03-15 주식회사 엘지화학 염료 화합물 및 포토폴리머 조성물
JP7580689B2 (ja) 2018-06-27 2024-11-12 ソニーグループ株式会社 デオキシリボースを含むリンカー基を有するポリマー色素
CN112566986A (zh) * 2018-08-10 2021-03-26 生命技术公司 经硅取代的罗丹明染料和染料缀合物
EP3849496B1 (en) 2018-09-11 2023-10-25 Oregon Health & Science University Near-infrared nerve-sparing benzo[c]phenoxazine fluorophores
KR102283067B1 (ko) * 2019-07-18 2021-07-28 아주대학교산학협력단 미토콘드리아를 표적으로 하는 신규한 근적외선 형광 프로브 및 이를 포함하는 종양 진단 및 치료 겸용 조성물
CN113383043A (zh) 2019-09-26 2021-09-10 索尼集团公司 具有连接体基团的聚合物串联染料
WO2021092035A1 (en) 2019-11-07 2021-05-14 Singular Genomics Systems, Inc. Silicon containing detectable compounds and uses thereof
WO2021116037A1 (en) * 2019-12-09 2021-06-17 F. Hoffmann-La Roche Ag Dicationic fluorescent dyes
JP7481122B2 (ja) * 2020-02-03 2024-05-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 蛍光色素及びその利用
US20240132725A1 (en) 2020-12-07 2024-04-25 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
CN113045599B (zh) * 2021-03-17 2022-04-19 山西大学 一种高对比度区分癌细胞/组织的方法及荧光探针的制备
WO2022241418A1 (en) * 2021-05-10 2022-11-17 University Of Virginia Patent Foundation Phosphinate ester-containing dyes having tunable properties and methods of making the same
CN113563298B (zh) * 2021-07-20 2023-07-28 北京大学 一类含水溶性取代基罗丹明荧光染料其制备方法和应用
JP7787670B2 (ja) * 2021-08-31 2025-12-17 富士フイルム株式会社 化合物及びこれを用いた標識生体物質
CN113801145B (zh) * 2021-10-12 2022-06-07 南京大学 一种激活型近红外小分子荧光探针及其制备方法与应用
CN114869227B (zh) * 2022-04-02 2025-09-05 北京信息科技大学 一种可穿戴式微型活体流式图像细胞仪
CN115322205B (zh) * 2022-04-06 2025-09-26 大连理工大学 一类近红外二区荧光染料及制备方法与抗肿瘤应用
US20250362644A1 (en) * 2022-11-04 2025-11-27 Lg Chem, Ltd. Hologram recording medium, preparation method thereof and optical element comprising the same
WO2024096360A1 (ko) * 2022-11-04 2024-05-10 주식회사 엘지화학 포토폴리머 조성물, 홀로그램 기록 매체, 이의 제조 방법 및 이를 포함하는 광학 소자
US12473382B2 (en) 2022-11-04 2025-11-18 Lg Chem, Ltd. Hologram recording medium and optical element comprising the same
US12359068B2 (en) 2023-02-10 2025-07-15 Singular Genomics Systems, Inc. Rhodamine fluorescent compounds and production methods thereof
WO2024225787A1 (ko) * 2023-04-28 2024-10-31 에스에프씨 주식회사 신규한 화합물 및 이의 용도

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100361999C (zh) * 2006-03-03 2008-01-16 大连理工大学 含硅元素的阳离子发色团及其衍生物
WO2012083064A1 (en) * 2010-12-16 2012-06-21 Southern Illinois University Carbondale Silaanthracene as a red and near infrared sensor and a method to manufacture such a sensor
WO2012111818A1 (ja) * 2011-02-18 2012-08-23 国立大学法人 東京大学 蛍光プローブ
WO2013029650A1 (en) * 2011-08-26 2013-03-07 Ecole Polytechnique Federale De Lausanne (Epfl) Cell permeable, fluorescent dye

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219335A (en) 1978-09-18 1980-08-26 E. I. Du Pont De Nemours And Company Immunochemical testing using tagged reagents
US6086737A (en) 1984-03-29 2000-07-11 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
US6048982A (en) 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5164297A (en) 1990-05-03 1992-11-17 Advanced Magnetics Inc. Solvent mediated relaxation assay system
US5445970A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
JPH08501097A (ja) 1992-09-04 1996-02-06 ザ ゼネラル ホスピタル コーポレーション 臨床診断及び治療用部分を含む生体適合性ポリマー
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
IT1276833B1 (it) 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US6046585A (en) 1997-11-21 2000-04-04 Quantum Design, Inc. Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6399392B1 (en) 1999-04-23 2002-06-04 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
ATE284433T1 (de) 1999-07-02 2004-12-15 Visen Medical Inc Fluorescierende cyaninlabels mit einem sulphamidobrückenglied
EP2325263B1 (en) 2000-09-29 2013-01-23 Life Technologies Corporation Modified carbocyanine dyes and their conjugates
WO2002038190A2 (en) 2000-10-27 2002-05-16 Beth Israel Deaconess Medical Center Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
EP1209205A1 (en) 2000-11-28 2002-05-29 Innosense S.r.l. Improved process and method for the preparation of asymetric monofunctionalised indocyanine labelling reagents and obtained compounds
EP1221465A1 (en) 2001-01-03 2002-07-10 Innosense S.r.l. Symmetric, monofunctionalised polymethine dyes labelling reagents
US20030044353A1 (en) 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
AU2003207438A1 (en) 2002-01-02 2003-07-24 Visen Medical, Inc. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
WO2003061711A2 (en) 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
AU2003225763A1 (en) 2002-03-11 2003-09-29 Visen Medical, Inc. Optical imaging probes
EP2410315B1 (en) 2002-06-04 2020-04-01 Visen Medical, Inc. Imaging volumes with arbitrary geometries in contact and non-contact tomography
EP1674579A4 (en) * 2003-09-05 2009-12-02 Daiichi Pure Chemicals Co Ltd FLUORESCENT PROBE
US20060239916A1 (en) 2005-01-07 2006-10-26 Kai Licha Use of cyanine dyes for the diagnosis of proliferative diseases
DK1934211T3 (en) 2005-09-02 2017-04-10 Visen Medical Inc Biocompatible N, N-disubstituted sulfonamide-containing fluorescent color markers
WO2007028118A2 (en) 2005-09-02 2007-03-08 Visen Medical, Inc. Nicotinic acid and picolinic acid derived near-infrared fluorophores
ES2612738T3 (es) 2005-09-02 2017-05-18 Visen Medical, Inc. Agentes de formación de imágenes fluorescentes biocompatibles
US9913917B2 (en) 2005-12-22 2018-03-13 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
WO2007109364A2 (en) 2006-03-20 2007-09-27 The General Hospital Corporation Intramolecularly quenched fluorochrome conjugates and methods of use
JP5643514B2 (ja) 2007-02-09 2014-12-17 ビセン メディカル， インコーポレイテッド ポリシクロ染料およびその使用
WO2008109832A2 (en) 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
EP2732826B1 (en) 2008-01-18 2017-11-08 Visen Medical, Inc. Fluorescent imaging agents
CA2715034C (en) 2008-03-14 2016-12-06 Visen Medical, Inc. Integrin targeting agents and in-vivo and in-vitro imaging methods using the same
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
JP5526124B2 (ja) * 2009-04-30 2014-06-18 国立大学法人 東京大学 近赤外蛍光化合物
US9180209B2 (en) 2011-02-28 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Non-peptidic quenched fluorescent imaging probes
EP2707102B1 (en) 2011-05-09 2019-11-13 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
CA2882019C (en) 2012-08-15 2021-02-09 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
CN105339436B (zh) 2013-03-15 2018-05-25 文森医学公司 4,4-二取代环己基桥连七甲川花菁染料及其应用
WO2014152298A1 (en) * 2013-03-15 2014-09-25 Promega Corporation New silicon and germanium dyes for use in genetic identity
AU2014228504C1 (en) 2013-03-15 2019-10-03 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100361999C (zh) * 2006-03-03 2008-01-16 大连理工大学 含硅元素的阳离子发色团及其衍生物
WO2012083064A1 (en) * 2010-12-16 2012-06-21 Southern Illinois University Carbondale Silaanthracene as a red and near infrared sensor and a method to manufacture such a sensor
WO2012111818A1 (ja) * 2011-02-18 2012-08-23 国立大学法人 東京大学 蛍光プローブ
WO2013029650A1 (en) * 2011-08-26 2013-03-07 Ecole Polytechnique Federale De Lausanne (Epfl) Cell permeable, fluorescent dye

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Design Strategy for a Near-Infrared Fluorescence Probe for Matrix Metalloproteinase Utilizing Highly Cell Permeable Boron Dipyrromethene;Takuya Myochin et al.;《Journal of the American Chemical Society》;20120725;第134卷;摘要，Figure2a、5a *
Development of an Si-Rhodamine-Based Far-Red to Near-Infrared Fluorescence Probe Selective for Hypochlorous Acid and Its Applications for Biological Imaging;Yuichiro Koide et al;《Journal of the American Chemical Society》;20110328;第133卷;参见第5680页摘要及Figure 1 *
Evolution of Group 14 Rhodamines as Platforms for Near-Infrared Fluorescence Probes Utilizing Photoinduced Electron Transfer;Yuichiro Koide et al.;《ACS Chemical Biology》;20110304;第6卷;摘要，Figure1、2、4、6 *
Ting Wang et al..Spirolactonized Si-rhodamine: a novel NIR fluorophore utilized as a platform to construct Si-rhodamine-based probes.《Chem. Commun.》.2012,第48卷 *
Yu Kushida et al..Red fluorescent scaffold for highly sensitive protease activity probes.《Bioorganic & Medicinal Chemistry Letters》.2012,第22卷 *
Yuichiro Koide et al..Development of NIR Fluorescent Dyes Based on Si−rhodamine for in Vivo Imaging.《Journal of the American Chemical Society》.2012,第134卷 *

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