CA2901379C - Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection - Google Patents
Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection Download PDFInfo
- Publication number
- CA2901379C CA2901379C CA2901379A CA2901379A CA2901379C CA 2901379 C CA2901379 C CA 2901379C CA 2901379 A CA2901379 A CA 2901379A CA 2901379 A CA2901379 A CA 2901379A CA 2901379 C CA2901379 C CA 2901379C
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- Prior art keywords
- alkylene
- compound
- alkyl
- optionally substituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000000338 in vitro Methods 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 238000011503 in vivo imaging Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000003384 imaging method Methods 0.000 abstract 2
- 239000000975 dye Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0816—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring comprising Si as a ring atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/28—Pyronines ; Xanthon, thioxanthon, selenoxanthan, telluroxanthon dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/008—Dyes containing a substituent, which contains a silicium atom
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361794188P | 2013-03-15 | 2013-03-15 | |
| US61/794,188 | 2013-03-15 | ||
| PCT/US2014/029350 WO2014144793A1 (en) | 2013-03-15 | 2014-03-14 | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2901379A1 CA2901379A1 (en) | 2014-09-18 |
| CA2901379C true CA2901379C (en) | 2023-05-16 |
Family
ID=50721890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2901379A Active CA2901379C (en) | 2013-03-15 | 2014-03-14 | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9649389B2 (enExample) |
| EP (1) | EP2970342B1 (enExample) |
| JP (1) | JP6606487B2 (enExample) |
| CN (1) | CN105073761B (enExample) |
| AU (1) | AU2014228504C1 (enExample) |
| CA (1) | CA2901379C (enExample) |
| WO (1) | WO2014144793A1 (enExample) |
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| AU2014228504C1 (en) | 2013-03-15 | 2019-10-03 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| CN105339436B (zh) | 2013-03-15 | 2018-05-25 | 文森医学公司 | 4,4-二取代环己基桥连七甲川花菁染料及其应用 |
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| CA2944476C (en) * | 2014-04-01 | 2021-06-15 | Howard Hughes Medical Institute | Azetidine-substituted fluorescent compounds |
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| US9180209B2 (en) | 2011-02-28 | 2015-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Non-peptidic quenched fluorescent imaging probes |
| EP2707102B1 (en) | 2011-05-09 | 2019-11-13 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
| US9346957B2 (en) * | 2011-08-26 | 2016-05-24 | École Polytechnique Fédérale De Lausanne (Epfl) | Cell permeable, fluorescent dye |
| CA2882019C (en) | 2012-08-15 | 2021-02-09 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| CN105339436B (zh) | 2013-03-15 | 2018-05-25 | 文森医学公司 | 4,4-二取代环己基桥连七甲川花菁染料及其应用 |
| WO2014152298A1 (en) * | 2013-03-15 | 2014-09-25 | Promega Corporation | New silicon and germanium dyes for use in genetic identity |
| AU2014228504C1 (en) | 2013-03-15 | 2019-10-03 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
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| AU2014228504A1 (en) | 2015-08-27 |
| JP6606487B2 (ja) | 2019-11-13 |
| US20140314677A1 (en) | 2014-10-23 |
| CA2901379A1 (en) | 2014-09-18 |
| US9649389B2 (en) | 2017-05-16 |
| CN105073761A (zh) | 2015-11-18 |
| WO2014144793A1 (en) | 2014-09-18 |
| JP2016521254A (ja) | 2016-07-21 |
| EP2970342B1 (en) | 2024-01-24 |
| AU2014228504B2 (en) | 2019-04-11 |
| CN105073761B (zh) | 2020-10-20 |
| AU2014228504C1 (en) | 2019-10-03 |
| EP2970342A1 (en) | 2016-01-20 |
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