CN105055748A - Osteosynthesis plaster and production method thereof - Google Patents

Abstract

The invention discloses an osteosynthesis plaster and a production method thereof. The osteosynthesis plaster comprises the following bulk drugs by weight with expression of g, 15-25g of stigma croci, 25-35g of dragons blood, 20-30g of pangolin, 40-60g of pseudo-ginseng, 40-45g of monkshood, 30-45g of Aconitum kusnezoffii, 35-50g of elderberry, 40-55g of clematis root, 40-50g of cortex acanthopanacis, 40-50g of rhizoma drynariae, 30-45g of obscured homalomenarhizome, 40-50g of cassia twig, 30-45g of pyrite, 40-55g of Gendarussa vulgaris, 40-55g of rhizoma arisaematis and 45-65g of artemisia anomala. The plaster can be used for external application, and has the advantages of convenient usage and fast effectiveness, and can be effectively used for treating protrusion of lumbar intervertebral disc, hyperplasia of waist and knees, ankylosing spondylitis and lumbar olisthe hyperplasia, through treatment application of 360 patients, cure rate is 88.6%, total efficiency is 97.7%, curative effect is reliable, and effect is obvious.

Description

A kind of pain bone-set plaster and boiling method thereof

Technical field

The invention belongs to Chinese medicine technical field, be specifically related to a kind of pain bone-set plaster and boiling method thereof.

Background technology

Osteopathia professional angle be " osteopathia ", it is one of orthopaedic disease three serious disease, and other two kinds are respectively " positive osteology " and " injury of tendon and muscle ".Osteopathia is also modal disease in orthopaedic disease, and it is mainly divided into: a few bulk contents such as congenital osteopathia, metabolic osteopathy, osteonecrosis, occupational osteopathia, endemicity osteopathia, joint degenerative osteopathy, bone tumor, bone carbuncle, bone tuberculosis, osteoarthrosis arthromyodynia, fistula card, clonic spasm of the muscle.

Osteopathia generally comprises: rheumatic arthritis, rheumatoid arthritis, degenerative osteoarthritis, ankylosing spondylitis, cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, hyperosteogeny, femur head necrosis, puerperal exposure to wind etc.

Rheumatic arthritis is a kind of common acute or chronic ICT.Can recurrent exerbation involve heart; Clinical with joint and muscle migrans miserable, heavily work, pain for feature, belong to allergic disease, be one of main manifestations of rheumatic fever, mainly with febris acuta and arthralgia onset.

The chronic generalized autoimmune disease of rheumatoid arthritis to be a kind of with articular synovitis be feature; The lasting recurrent exerbation of synovitis, can cause the destruction of intraarticular cartilage and bone, joint function disturbance, even maimed.Vasculitis pathological changes involves each organ of whole body, therefore primary disease is also called rheumatoid disease.

Degenerative osteoarthritis, also known as hypertrophiarthritis, refers to that some old peoples usually have lumbago, skelalgia, arthralgia.Because it is more common in old people, thus also referred to as senile arthritis.Senescent deterioration is the main cause causing degenerative osteoarthritis.After person in middle and old age, all can there is degeneration change in all histoorgans; Bone and joint tissue no exception, degeneration change, be especially apt to occur in the joint of load-bearing and the joint of multi-activity.Excessive heavy burden or some joint of excessive use, can promote the generation that degeneration changes.In addition, as intra-articular fracture, diabetes, long-term use the factors such as adrenocortical hormone irrelevantly, all can promote the formation that degeneration change and accelerate the development that already present degeneration changes.

Ankylosing spondylitis belongs to rheumatism category, the one of seronegative spondyloanthropathy.This cause of disease is still not clear, and take spinal column as the chronic disease of major lesions, involves sacroiliac joint, cause rigid spine and fibrosis, causes eye, lung, muscle, skeleton pathological changes in various degree, belongs to autoimmune disease.

Cervical spondylosis, also known as cervical spine syndrome, is the general name of osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, Cervical disc extrusion, is a kind of illness changing into basis with degeneration pathology.Strain for a long time mainly due to cervical vertebra, hyperosteogeny, or prolapse of intervertebral disc, ligament thicken, and cause cervical vertebra spinal cord, nerve root or vertebral artery pressurized, cause a series of handicapped clinical syndrome.Show as intervertebral disc degradation itself and insecondary a series of pathological change thereof, as vertebra joint unstability, loosen; Nucleus pulposus or deviate from; Bony spur is formed; The spinal canal stenosis etc. of ligament plumpness and secondary, stimulates or has oppressed the tissues such as the nerve root of vicinity, spinal cord, vertebral artery and cervical region sympathetic nerve, and cause the syndrome of various sings and symptoms.

Medically said lumbar spondylosis, covers illness such as " prolapse of lumbar intervertebral disc, lumbar vertebra hyperosteogeny, lumbar muscle strain, lumbar sprain, lumbar degenerative disease, rheumatism or rheumatoid lumbago, tuberculosis of spine, wind cold-damp lumbago, congestive lumbago, humid lumbago, suffering from a deficiency of the kidney property lumbago, cervical spondylosiss ".

The common disease that scapulohumeral periarthritis is is cardinal symptom with shoulder arthralgia and inconvenient activity.Primary disease send out the age at about 50 years old well, women's sickness rate, a little more than male, is more common in physical labourer.As can not get effective treatment, likely have a strong impact on the functional activity of shoulder joint.According to clinical observation, hospital's common medicine closes Sheng hall ancestor and is treated, and the early stage shoulder joint of primary disease is paroxysmal pain, often bring out because of Changes in weather and fatigue, develop into rest pain later gradually, and increase the weight of gradually, light night in daytime is heavy, shoulder joint to the active of all directions and passive activity all limited.When shoulder is subject to tractive, can causes and have an intense pain.Shoulder joint can have extensive tenderness, and to cervical region and ancon radiation, also can occur the atrophy of triangular muscle in various degree.

Bone matrix hyperplasia is also called hyperplastic osteoarthritis, osteoarthritis, degenerative joint disease, senile arthritis, hypertrophiarthritis, soft tissue degeneration, the degeneration such as cartilage, intervertebral disc, ligament owing to forming joint, joint margins forms bony spur, synovial membrane plumpness waits change, and occurs osteoclasia, causes insecondary hyperosteogeny, cause joint deformity, when being subject to abnormal load, cause arthralgia, a kind of disease of the symptoms such as limitation of activity.Hyperostosis constitutional estranged and Secondary cases two kinds.

Femur head necrosis, also known as ischemic necrosis of femoral head, is one of common osteoarthritis.Mostly because the illness such as rheumatism, hematopathy, bends, burn cause, first destroy the blood supply of adjacent joints covering weave, and then cause necrosis.Its cardinal symptom, develops into rest pain gradually from discontinuity pain, then cause muscle spasm by pain, joint motion is restricted, finally cause and seriously disable and walk lamely.Hormone drug also can cause the generation of primary disease.The traditional Chinese medical science thinks that disease occurrence cause is exopathogenic factor and endogenous cause of ill, and endogenous cause of ill exopathogenic factor interacts, and makes yin-Yang disequilibrium, and the mistake of QI and blood is permanent and give birth to disease, also known as " thigh pivot numbness ", " rheumatism involving the bone ", " bone withers ".

At present, the patent documentation in treatment orthopaedic disease also has many reports.Such as: 1, application number is 201510026701.7, name is called the application for a patent for invention of " removing obstruction inchannels to removing blood stasis bone growth promoting plaster and preparation method thereof ".2, application number is 200610046888.8, name is called the application for a patent for invention of " a kind of plaster for the treatment of osteopathia and preparation method thereof ".3, application number is 201010134579.2, name is called the application for a patent for invention of " a kind of plaster for the treatment of osteopathia ".

Summary of the invention

The technical problem to be solved in the present invention is: provide a kind of pain bone-set plaster and boiling method thereof.Pain bone-set plaster of the present invention is mainly used in treatment prolapse of lumbar intervertebral disc, neck shoulder waist knee joint hypertrophy, ankylosing spondylitis and lumbar spondylolisthesis hyperplastic conditions.Utilize pain bone-set plaster of the present invention to treat this four kinds of orthopaedic diseases, therapeutic process is without any toxic and side effects, and therapeutic effect is remarkable.

In order to solve the problem, the technical scheme that the present invention takes is:

The invention provides a kind of pain bone-set plaster, represent with weight g, described pain bone-set plaster is primarily of crude drug Stigma Croci 15 ~ 25g, Sanguis Draxonis 25 ~ 35g, Squama Manis 20 ~ 30g, Radix Notoginseng 40 ~ 60g, Radix Aconiti 30 ~ 45g, Radix Aconiti Kusnezoffii 30 ~ 45g, Ramulus Sambuci Williamsii 35 ~ 50g, Radix Clematidis 40 ~ 55g, Cortex Acanthopancis 40 ~ 50g, Rhizoma Drynariae 40 ~ 50g, Rhizoma Homalomenae 30 ~ 45g, Ramulus Cinnamomi 40 ~ 50g, Pyritum 30 ~ 45g, Herba Gendarussae 40 ~ 55g, Rhizoma Arisaematis 40 ~ 55g and Herba Artemisiae Anomalae 45 ~ 65g make.

According to above-mentioned pain bone-set plaster, described pain bone-set plaster is primarily of crude drug Stigma Croci 18 ~ 22g, Sanguis Draxonis 28 ~ 32g, Squama Manis 22 ~ 26g, Radix Notoginseng 45 ~ 55g, Radix Aconiti 35 ~ 42g, Radix Aconiti Kusnezoffii 35 ~ 42g, Ramulus Sambuci Williamsii 38 ~ 45g, Radix Clematidis 45 ~ 50g, Cortex Acanthopancis 45 ~ 48g, Rhizoma Drynariae 42 ~ 46g, Rhizoma Homalomenae 35 ~ 40g, Ramulus Cinnamomi 45 ~ 48g, Pyritum 36 ~ 45g, Herba Gendarussae 45 ~ 52g, Rhizoma Arisaematis 45 ~ 50g and Herba Artemisiae Anomalae 50 ~ 60g make.

According to above-mentioned pain bone-set plaster, described Radix Aconiti is Radix Aconiti Preparata, and described Radix Aconiti Kusnezoffii is Radix Aconiti Kusnezoffii Preparata.

In addition, provide a kind of boiling method of pain bone-set plaster, described boiling method comprises the following steps:

A, first take various crude drug according to the raw material composition and ratio ratio of above-mentioned pain bone-set plaster, for subsequent use;

B, the various crude drug mix homogeneously taken by step a, then pour in 2000 ~ 3000g Oleum Sesami and heat, after being heated to boiling, temperature is controlled under 40 ~ 60 DEG C of conditions, boil 40 ~ 80 minutes, boil in process and constantly stir, after boiling, filter medicinal residues, obtain lubricate;

C, step b gained lubricate is heated to boiling, then slowly adds hydrargrum oxydatum crudum, the mass ratio that both plaster and hydrargrum oxydatum crudum add is 2:1, after adding hydrargrum oxydatum crudum, temperature is controlled under 40 ~ 60 DEG C of conditions, boil 1 ~ 1.5h, boil in process and constantly stir, after boiling, obtain plaster;

D, the plaster obtained by step c are poured into water immersion 20 ~ 24h, pull out after immersion, are spread out on cloth, obtain pain bone-set plaster.

the pharmacological action of the various crude drug of the present invention:

Stigma Croci: also known as Stigma Croci, this moral character is put down, sweet in the mouth; Enter the heart, liver two warp.Effect: 1, blood circulation promoting and blood stasis dispelling: this medicine color is red, enters conscience warp, and sweet in the mouth is trembled with fear, and enriches blood and invigorates blood circulation, blood stasis dispelling easing the affected liver, the merit of removing pathogenic heat from blood and toxic substance from the body.Be usually used in married woman's amenorrhea, the various diseases such as postnatal blood stasis stomachache, treating swelling and pain by traumatic injury, typhoid fever are gone mad.2, dispersing stagnation and relieving accumulation of pathogens: the sweet increasing of Stigma Croci nature and flavor, enters liver heart channel, be good at blood circulation promoting and blood stasis dispelling, dispersing the stagnated live-QI to relieve the stagnation of QI regulating QI to relieve pain.The diseases such as be usually used in troubled thoughts pent-up, chest and diaphragm feeling of fullness, palpitation with fear is in a trance, breast side of body feeling of distension and oppression.

Sanguis Draxonis: this product sweet in the mouth, salty, property is put down; Mild toxicity.GUIXIN warp, Liver Channel.Effect: this product has dissipating blood stasis analgesic therapy, hemostasis, the effects such as promoting tissue regeneration and ulcer healing; Cure mainly traumatic injury, ecchymoma due to internal injury, dysmenorrhea, postpartum stagnation is suffered from abdominal pain, continuous bleeding due to traumatic injury, scrofula, the card such as ecthyma unhealed for long time and hemorrhoid.

Squama Manis: cold nature, salty in the mouth, enters liver, stomach two warp.Effect: 1, dredging collateral searches wind: this moral character is apt to away alter, and dredging collateral searches wind, expelling wind and dampness, through sick institute, with the joint insensitive impediment that disappears, stiff distortion.2, eliminating carbuncle is burst pus: this product promoting flow of QI and blood, dysmenorrhea dissipating blood stasis, and the product drawing heat clearing away, through sick institute, the person that do not become pus, disappear and loose it, the person that become pus, burst and thoroughly it.The machine that pus of carbuncle will become into, use the most suitable.3, actively to stimulate the menstrual flow: this product can dispelling the stagnated QI promoting the circulation of blood, it is loose to walk to alter again row, and gas clots absorbing is opened, and menses are descending.4, dredging collateral for promoting lactation.5, Xiao Disorder eliminate indigestion: this product is salty-cold, can hard masses softening and resolving, can invigorate blood circulation by dredging collateral again, and it is loose that merit specially walks to alter row, and priming goes directly disease institute, therefore the use of You Xiao Disorder eliminate indigestion, eliminating stagnation.

Radix Notoginseng: warm in nature, sweet in the mouth, micro-hardship, nontoxic; Enter liver, stomach, large intestine three warp.Effect: 1, stop blooding dissipating blood stasis: this product kind hemostasis dissipating blood stasis, existing commonly using controls blood disorder, as cards such as metrorrhagia, puerperal blood faints, retention of lochia, traumatic hemorrhage.2, promoting blood circulation and detumescence: this product bitter in the mouth, warm in nature, it is logical that hardship lets out temperature, enters blood system then blood circulation promoting and blood stasis dispelling, detumescence de-swelling, with controlling traumatic injury, unknown carbuncle.3, eliminating stasis to stop pain: this product blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, with controlling pain due to blood stasis, flutters damage pain, the cards such as carbuncle pain, and analgesic efficacy is best.

Radix Aconiti Preparata: this product acrid in the mouth, hardship, heat is poisonous; GUIXIN warp, Liver Channel, kidney channel and spleen channel etc.Effect: the effects such as this product has expelling wind and removing dampness, antalgic; Commonly use and control anemofrigid-damp arthralgia, mastalgia, chest pain with distension sensation, arthralgia, trusted subordinate's cold type of pain, the cards such as colic of cold type is had a pain, narcotic analgesic.

Radix Aconiti Kusnezoffii Preparata: this product acrid in the mouth, hardship, hot in nature; GUIXIN warp, Liver Channel, kidney channel and spleen channel.Effect:

The effects such as this product has expelling wind and removing dampness, antalgic; Commonly use and control anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, the cards such as colic of cold type pain relieving.

Ramulus Sambuci Williamsii: this product sweet in the mouth, hardship, property is put down, nontoxic; Return Liver Channel.Effect: this product has expelling wind and removing dampness, promoting blood circulation and stopping pain, hemostasis, heat-clearing and toxic substances removing, effects such as synthetism of stimulating the menstrual flow; Commonly use and control pain of dampness syndrome, gout, various diseases associated with inflammation, rheumatic arthritis, lumbago and skelalgia, fracture, tumor, Kaschin-Beck disease, acute and chronic nephritis, rubella, traumatic injury, the cards such as fracture swells and ache, traumatic hemorrhage.

Radix Clematidis: this product acrid in the mouth is salty, warm in nature, poisonous; Enter urinary bladder channel.Effect: this product has expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the effects such as the loose hypochondriac lump; Commonly use and control gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, the cards such as all a fishbone or other bone caught in the throat pharynxs.

Cortex Acanthopancis: this product belongs to dispel-wind drug, blood circulation promoting medicine; There is wind-damp dispelling, strengthening bone and muscle, the effects such as blood circulation promoting and blood stasis dispelling; Commonly use and control cold-damp numbness, muscles and bones contraction is anxious, lumbago, sexual impotence, flaccidity of the lower limbs, edema, beriberi, the cards such as skin ulcer cellulitis swells and ache, traumatic injury impairment caused by overstrain.

Rhizoma Drynariae: this product bitter in the mouth, warm in nature; Return kidney channel, Liver Channel.Effect: this product has the kidney invigorating bone strengthening, continues and hinders the effects such as pain relieving; Commonly use and control lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, the cards such as injured bone.

Rhizoma Homalomenae: this product bitter in the mouth, pungent, warm in nature, returns Liver Channel, kidney channel.Effect: this product has wind-damp dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, pain relieving, the effects such as detumescence; Conventional dispelling the wind and dampness pathogens arthralgia pain, podomere acid is educated, flaccidity of extremities, traumatic injury, stomachache, and carbuncle skin ulcer is swollen waits card.

Ramulus Cinnamomi: warm in nature, acrid in the mouth, sweet; Enter bladder, the heart, lung three warp.Effect: 1, expelling pathogenic factors from muscles by diaphoresis: this product gas Bao Shengfu, upwards outwards, thoroughly reaches battalion and defends, expelling pathogenic factors from muscles by diaphoresis, wind dispelling cold expelling, is the product that outer solution exterior syndrome due to wind-cold is conventional.Commonly use and control wind and cold exterior deficiency, Solar watch is strongly fragrant, exterior cold and interior heat.2, warm promoting blood circulation: the pungent temperature of this product, the yang-energy of temperature the whole body, the blood vessels on the logical whole body.Interior warm internal organs, outer loose exterior cold is warm promoting blood circulation key medicine.Conventional control that blood deficiency is caught cold, cold stagnant uterus, arthralgia due to stagnation of blood.3, warming YANG activating QI: the pungent temperature of this product, rouses oneself yang-energy, exploitation space between skin and muscles, regulating fluid apssage, helps the sun of three Jiao, is the product that phlegm retention water must be used.Conventional temperature of controlling is reduced phlegm drink, warming YANG to promote diuresis, sun water-retention.4, warm smart eliminating impediment: this product temperature three-way meridian, can pungently fall apart outward, expelling wind and dampness; Nei Kewentong, dispersing cold for relieving pain, more can lead all medicines of wind-damp dispelling, and through sick institute, receives the effect of killing three birds with one stone.5, the logical breast sun of temperature: this product is pungent passes through, and temperature can be supporing yang is warm breast sun good merchantable brand.Commonly use and control the thoracic obstruction, cardiopalmus.6, warming spleen and stomach for dispelling cold: this product Xin Ganwen, pungent can circulation of qi promoting, temperature can cold expelling, sweet can tonify deficiency, middle-jiao yang, function of the spleen and stomach strong fortune cold-evil remove, and pain is only.7, Tong Jing Xiao Disorder: this product temperature promoting blood circulation, neck medicine goes directly disease institute, and Huan Xiao Disorder block, very imitates more outstanding.8, making the adverse-rising QI downwards: the sun of Ramulus Cinnamomi temperature heart kidney, the gas that precipitation is cold, has the merit of making the adverse-rising QI downwards.

Pyritum: this product is into blood blood, the medicine of reunion of fractured tendons and bones.There is purposes such as promoting union of fracture effect, antifungic action.

Herba Gendarussae: this product acrid in the mouth, hardship, property is put down; Return Liver Channel, kidney channel and lung meridian.Effect: this product has wind-damp dispelling, scattered silt blood, the effects such as reuniting the fractured tendons and bones; Conventional dispelling the wind and dampness pathogens arthralgia pain, menoxenia, puerperal abdonimal pain, treating swelling and pain by traumatic injury, the cards such as fracture.

Rhizoma Arisaematis: this product bitter in the mouth, pungent, warm in nature, poisonous; Return lung, liver, spleen channel.Effect: this product has drying dampness to eliminate phlegm, expellings wind and relieving convulsion, the effects such as mass dissipating and swelling eliminating; Be usually used in pertinacious phlegm cough, dizziness due to wind-phlegm, middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, the cards such as tetanus.

Herba Artemisiae Anomalae: this product bitter in the mouth, warm in nature, enter heart channel, spleen channel.Effect: this product has removing blood stasis and stimulates the menstrual flow, healing up sore and subduing swelling, hemostasis of curing the wound, promoting digestion and removing stagnation, the merits such as appetizing of being amusing; Conventional control amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal congestion, traumatic injury, the cards such as incised wound is hemorrhage, Yong Du burning swelling.

Medicament composing prescription compatibility mechanism of the present invention: in medicine of the present invention, Stigma Croci, Sanguis Draxonis, Squama Manis and Radix Notoginseng are monarch drug; Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Ramulus Sambuci Williamsii and Radix Clematidis are ministerial drug; Cortex Acanthopancis, Rhizoma Drynariae, Rhizoma Homalomenae and Ramulus Cinnamomi are adjuvant drug; Pyritum, Herba Gendarussae, Rhizoma Arisaematis and Herba Artemisiae Anomalae are for making medicine.Prescription monarch compatibility of the present invention is reasonable, and all medicines share, and inside reach and pass through inside, and has good therapeutic effect to orthopaedic diseases such as prolapse of lumbar intervertebral disc, neck shoulder waist knee joint hypertrophy, ankylosing spondylitis and lumbar spondylolisthesis hypertrophy.

The using method of pain bone-set plaster of the present invention: plaster of the present invention is affixed on affected part, fixes with medical proof fabric; Within 5-7 days, change once, usual 5-7 pastes a course for the treatment of.

positive beneficial effect of the present invention:

1, the present invention is according to the theory of traditional Chinese medical science organic conception, to effect a permanent cure, compensate for the defect that Western medicine is cured the symptoms, not the disease.Dosage form plaster of the present invention is used for external application, has easy to use, the feature of instant effect; Effectively can treat prolapse of lumbar intervertebral disc, neck shoulder waist knee joint hypertrophy, ankylosing spondylitis and lumbar spondylolisthesis hypertrophy.For patient removes misery, avoid the sequela caused by operation.Through adding up 360 routine patient treatment application, cure rate reaches 88.6%, total effective rate 97.7%, and curative effect is reliable, Be very effective.

2, for many years, utilize plaster treatment prolapse of lumbar intervertebral disc of the present invention, neck to take on waist knee joint hypertrophy, ankylosing spondylitis and lumbar spondylolisthesis hypertrophy patient many cases, carried out detail statistics to the treatment situation of wherein 360 routine patients, statistics refers to table 1.

。

The general diagnostic standard of prolapse of lumbar intervertebral disc:

1) skelalgia is more serious than lumbago, typical sciatica of nerve roots;

2) lower limb paraesthesia, single nerve root is at lower limb or foot paralgia (waist 5, sacrum 1 or waist 4 spinal nerve root areal area);

3) under, spinal nerves root involves sign: straight-leg raising test is less than 50 °; Leg raising straight strengthens test for positive; Strong directly raising tests the positive.Above three kinds of signs must have a kind of for positive.

4) in neurological physical examination, amyotrophy, myasthenia, paraesthesia and reflection change four kinds have two kinds for positive.

5) the unenhanced or waist nuclear magnetic resonance check of myelography, lumbar intervertebral disc CT is positive findings and is consistent with the clinical symptoms of nerve root of getting involved and sign.

Above five standards are the positive, just can make the diagnosis of prolapse of lumbar intervertebral disc.

The diagnostic criteria (the New York standard of Americanism damp disease association revision in 1984) of ankylosing spondylitis:

(1) clinical criteria:

1. low back pain continues at least 3 months, and movable (but not rest) is alleviated afterwards.

2. lumbar vertebra is at limitation of activity that is vertical and horizontal plane.

3. the normal person of chest expanding degree more same age, sex reduces.

(2) standard is made a definite diagnosis:

Possess one-sided III ~ IV grade or II ~ III grade of x-ray sacroiliitis, to add in clinical criteria 3 at least 1.

Activeness diagnosis should be carried out when diagnosing ankylosing spondylitis.At present, judging that the common counter of ankylosing spondylitis activity has clinically: morning is stiff >=and 30 minutes; Because of pain, stiff and affect sleep; Periphery arthritis; ESR >=30mm/1h(westergren method); CRP >=20mg/L; 1gA >=3.9g/L; Rachialgia; Pain or stiff when chest pain or neck activity during eupnea; Daytime or night two buttocks pain.

Lumbar spondylolisthesis: be often referred to certain joint vertebral body and be shifted forward or backward, being common in lumbar vertebra, is one of commonly encountered diseases of orthopaedics at China's lumbar spondylolisthesis.At present lumbar spondylolisthesis is divided into dysplasia (comprising height dysplasia and low dysplasia), isthmus fragility, degenerated, traumatic and pathologic etc. 6 kinds.Wherein again with isthmus fragility and degenerated common.The sickness rate of lumbar spondylolisthesis is different because of ethnic, regional, is 4 ~ 6%, accounts for 4.7 ~ 5% of population in China in Europe; The isthmus slippage caused of bursting apart accounts for 15%, and degenerative lumbar spondylolisthesis accounts for 35%.More with 20 ~ 50 years old at the age of onset of China's lumbar spondylolisthesis, account for 85%; Affected males is more than women, and the ratio of men and women is 29:1.The common position of lumbar spondylolisthesis is L4 ~ L5 and L5 ~ S1, and its middle part of the side 5 vertebral body incidence rate is 82 ~ 90%

The judgement of lumbar spondylolisthesis hypertrophy:

I type: dysplasia type; Be sacrum 1 superior articular process or waist 5 vertebral arch congenital defect, the slippage forward of waist 5 vertebra cannot be stoped.

II type: isthmus type; Be isthmus (between upper and lower articular process) stress fracture or prolongation, superior articular process is moved forward together with upper lumbar vertebra.

III type: regression type; Due to long-term regression, make articular process and intervertebral disc shakiness, and slippage occurs, but the degree of slippage is all lighter.

IV type: wound; Be that acute trauma causes pedicle of vertebral arch, vertebral plate, fracture of articular process, this kind of is rare.

V type: pathotype; For systemic disease is as osteogenesis imperfecta, lopsided osteitis etc.

Neck shoulder waist knee joint hypertrophy: also belong to hyperosteogeny, bone matrix hyperplasia causes joint, local, muscle, ligament moving obstacle with sclerotin pathological proliferation, and the pain that occurs together is the disease of cardinal symptom.The places such as cervical vertebra, lumbar vertebra, joint and calcaneus can be occurred in.Primary disease is apt to occur in the person in middle and old age of more than 40 years old and is engaged in the staff of load-bearing, for a long time station, sitting, common with the pathological changes of the larger joint of range of activity, vertebra.The cause of disease of hyperosteogeny is not bright so far, belongs to the category of senile degeneration more.Basic understandings is on interior gene basis, is caused morbidity by bringing out of exopathogenic factor.At present, doctor trained in Western medicine adopts non-hormone antiinflammation pain-stopping pharmaceutical, physical therapy and operative treatment, has certain effect, but there is no special effective therapy so far to relief of symptoms.

therapeutic Method:

Prolapse of lumbar intervertebral disc, neck shoulder waist knee joint hypertrophy, ankylosing spondylitis and the lumbar spondylolisthesis hypertrophy patient invention plaster that loses money in a business is treated in affected part; The pharmaceutical formulation that plaster of the present invention adopts is: Stigma Croci 15 ~ 25g, Sanguis Draxonis 25 ~ 35g, Squama Manis 20 ~ 30g, Radix Notoginseng 40 ~ 60g, Radix Aconiti 30 ~ 45g, Radix Aconiti Kusnezoffii 30 ~ 45g, Ramulus Sambuci Williamsii 35 ~ 50g, Radix Clematidis 40 ~ 55g, Cortex Acanthopancis 40 ~ 50g, Rhizoma Drynariae 40 ~ 50g, Rhizoma Homalomenae 30 ~ 45g, Ramulus Cinnamomi 40 ~ 50g, Pyritum 30 ~ 45g, Herba Gendarussae 40 ~ 55g, Rhizoma Arisaematis 40 ~ 55g and Herba Artemisiae Anomalae 45 ~ 65g.

The using method of plaster of the present invention: plaster of the present invention is affixed on affected part, fixes with medical proof fabric; Within 5-7 days, change once, usual 5-7 pastes a course for the treatment of.

Therapeutic effect of syndrome criterion:

(1) clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%;

Treat after terminating the course for the treatment of, symptom, sign disappear, on inspection leading indicator recovery or close normal.

(2) effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.Treat the course for the treatment of

After end, symptom, sign disappear substantially, and leading indicator also has clear improvement on inspection.

(3) effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.Treat the course for the treatment of

After end, symptom, sign alleviate, and leading indicator is also improved on inspection.

(4) invalid: tcm clinical practice symptom, sign are all not improved, even increase the weight of, syndrome integral reduces

Less than 30%.Treat after terminating the course for the treatment of, symptom, sign are without obvious improvement.

Utilized the curative effect situation of the routine orthopaedic disease patient of plaster treatment 360 of the present invention from table 1, utilize plaster treatment orthopaedic disease of the present invention, its therapeutic effect is remarkable, and total effective rate reaches 97.7%.

model case:

1, high certain, female, 50 years old, this patient suffered from prolapse of lumbar intervertebral disc, and it is existing for many years to oppress right lower limb nerve, and current pain cannot be walked.Use plaster of the present invention to be affixed on affected part to treat, after using 3 courses for the treatment of, symptom disappears substantially, continues 2 courses for the treatment of of use subsequently, transference cure, through X-ray examination, substantially recovers normal, recovery from illness.Pay a return visit 3 years without recurrence.

2, Chen, man, 26 years old, suffers from prolapse of lumbar intervertebral disc after testing existing 3 years, pushes down both legs nerve, loses normal function of walking, cannot sitting.Use plaster of the present invention to be affixed on affected part to treat, after treating 4 courses for the treatment of, various symptom disappears substantially, and after testing, outstanding symptom disappears; Continue use subsequently to be consolidated 2 courses for the treatment of, recovery from illness.Within 1 year, pay a return visit afterwards without recurrence.

3, Lee so-and-so, female, 64 years old, this patient suffered from prolapse of lumbar intervertebral disc, the serious slippage of lumbar vertebra.Use plaster of the present invention to be affixed on affected part to treat, after treating 4 half courses for the treatment of, the symptom such as pain, numbness disappears substantially, recovery from illness.Continue use subsequently to be consolidated 2 courses for the treatment of.On inspection, various transference cure, recovers normal.Within 1 year, pay a return visit afterwards without recurrence.

4, Guo, female 48 years old, suffers from cervical spondylosis for many years, once carried out hospitalization in institute of traditional Chinese medicine of Henan Province, but therapeutic effect is undesirable.Went to a doctor in here afterwards, and dizzy serious when coming, the severity of telling, cannot normally walk.Use plaster of the present invention to be affixed on affected part to treat, after treating 4 courses for the treatment of, stop vomiting, dizziness alleviates; Rear continuation uses 2 courses for the treatment of of plaster of the present invention, on inspection, recovers normal, recovery from illness.Within 2 years, pay a return visit afterwards without recurrence.

5, revive certain, man, 54 years old, suffers from cervical spondylosis for many years, loses work capacity, and through many places treatment, but therapeutic effect is undesirable.Went to a doctor in here afterwards, uses plaster of the present invention to be affixed on affected part and treat, and after treating 4 courses for the treatment of, various symptom disappears substantially; Rear continuation uses 2 courses for the treatment of of plaster of the present invention, on inspection, recovers normal, recovery from illness.Within 3 years, pay a return visit afterwards without recurrence.

6, Lee, female, 58 years old, cervical vertebra 2 saved outstanding, 1 joint slippage, dizzy, both hands are numb.Treat in here, use plaster of the present invention to be affixed on affected part and treat, after treating 4 courses for the treatment of, on inspection, reduction of spondylolisthesis is outstanding normal.Within 1 year, pay a return visit afterwards without recurrence.

7, Lv, man, 45 years old, suffers from prolapse of lumbar intervertebral disc for many years, cannot normally walk at present, can not go to work.Through many places treatment, poor effect.Went to a doctor in here afterwards, and use plaster of the present invention to be affixed on affected part and treat, after treating 3 courses for the treatment of, various symptom obviously alleviates; After continuing to use 2 courses for the treatment of of plaster treatment of the present invention subsequently, recover normal on inspection.Within 2 years, pay a return visit afterwards without recurrence.

8, Lee so-and-so, female, 85 years old, suffers from osteonecrosis, can not walk, through many places treatment, also non-positive effect.Here was treated afterwards, used plaster of the present invention to be affixed on affected part and treated, and after treating 5 courses for the treatment of, various symptom disappears substantially, can normally walk; Plaster treatment of the present invention is used to consolidate 2 courses for the treatment of with continuation.All are paid a return visit normal after half a year.

9, Lee so-and-so, man, 58 years old, suffer from spondylitis for many years, have a back ache unbearably, through many places treatment, after treatment again and again.Went to a doctor in here afterwards, and use plaster of the present invention to be affixed on affected part and treat, after treating 3 courses for the treatment of, various symptom disappears substantially; Plaster treatment of the present invention is used to consolidate 2 courses for the treatment of with continuation.All are paid a return visit normal after half a year.

10, Liu, man, 44 years old, be chief complaint with " neck, waist and two hip limitation of activity 10 years ", cervical vertebra, lumbar vertebra, lumbar vertebra limitation of activity, can not squat down, and lower back is stiff, fear of cold is afraid of cold, frequent urination at night, gastral cavilty portion distension, loose stool; Be diagnosed as " ankylosing spondylitis ".Went to a doctor in here afterwards, and use plaster of the present invention to be affixed on affected part and treat, after treating 3 courses for the treatment of, various symptom disappears substantially; Plaster treatment of the present invention is used to consolidate 1 course for the treatment of with continuation.All are paid a return visit normal after half a year.

11, Zhang, man, 19 years old, fall ill 2 years, spinal column pain at night, had stiff sense, rises morning obviously, accompany weak, become thin, Chronic Intermittent low grade fever, cervical vertebra, thoracic vertebra, lumbar vertebra limitation of activity, pelvic compression and separation test the positive; Be diagnosed as " ankylosing spondylitis ".Went to a doctor in here afterwards, and use plaster of the present invention to be affixed on affected part and treat, after treating 3 courses for the treatment of, various symptom disappears substantially; Plaster treatment of the present invention is used to consolidate 1 course for the treatment of with continuation.All are paid a return visit normal after 1 year.

12, hole, man, 23 years old, fall ill 3 years, spinal pain, deadlock sense in morning obviously, accompany weak, become thin, anemia, persistence low grade fever, waist is anteflexion, after stretch limitation of activity, the pelvic compression and separation test positive.Be diagnosed as " ankylosing spondylitis ".Went to a doctor in here afterwards, and use plaster of the present invention to be affixed on affected part and treat, after treating 3 courses for the treatment of, various symptom disappears substantially.All are paid a return visit normal after 1 year.

13, Guo so-and-so, female, 65 years old, two knee joint pain was existing more than 3 years, can walk reluctantly.Also go to many places to treat, but therapeutic effect is not satisfactory, again and again.Went to a doctor in here afterwards, and use plaster of the present invention to be affixed on affected part and treat, after treating 3 courses for the treatment of, various symptom disappears substantially; Plaster treatment of the present invention is used to consolidate 2 courses for the treatment of with continuation.All are paid a return visit normal after 1 year.

14, model, man, 72 years old, there was an angioma at vertebra place, pressuring nerve, waist lower limb numbness, hurt like hell.Once went local hospital to carry out operative treatment, but operate on rear angioma and cannot extract; Go to again Beijing to treat subsequently, but angioma still cannot be extractd by operation.Went to a doctor in here afterwards, and use plaster of the present invention to be affixed on affected part and treat, after treating 5 courses for the treatment of, various symptom disappears substantially; Plaster treatment of the present invention is used to consolidate 2 courses for the treatment of with continuation.On inspection, angioma disappears.All are paid a return visit normal after 1 year.

15, Wu, female, 76 years old, suffers from prolapse of lumbar intervertebral disc existing more than 3 years, hypertrophy, narrow, slippage, and canalis spinalis degeneration.Went to a doctor in here afterwards, and use plaster of the present invention to be affixed on affected part and treat, after treating 5 courses for the treatment of, various symptom disappears substantially; Plaster treatment of the present invention is used to consolidate 2 courses for the treatment of with continuation.On inspection, reduction of spondylolisthesis, degeneration place recovers normal substantially.All are paid a return visit normal after 1 year.

four, detailed description of the invention:

Set forth the present invention further below in conjunction with embodiment, but do not limit content of the present invention.

Embodiment 1:

Pain bone-set plaster of the present invention, represents with weight g, by crude drug Stigma Croci 20g, Sanguis Draxonis 30g, Squama Manis 25g, Radix Notoginseng 50g, Radix Aconiti Preparata 38g, Radix Aconiti Kusnezoffii Preparata 38g, Ramulus Sambuci Williamsii 42g, Radix Clematidis 48g, Cortex Acanthopancis 46g, Rhizoma Drynariae 45g, Rhizoma Homalomenae 38g, Ramulus Cinnamomi 47g, Pyritum 40g, Herba Gendarussae 48g, Rhizoma Arisaematis 48g and Herba Artemisiae Anomalae 55g make.

Embodiment 2:

Pain bone-set plaster of the present invention, represents with weight g, by crude drug Stigma Croci 18g, Sanguis Draxonis 28g, Squama Manis 22g, Radix Notoginseng 45g, Radix Aconiti Preparata 35g, Radix Aconiti Kusnezoffii Preparata 35g, Ramulus Sambuci Williamsii 38g, Radix Clematidis 45g, Cortex Acanthopancis 45g, Rhizoma Drynariae 42g, Rhizoma Homalomenae 35g, Ramulus Cinnamomi 45g, Pyritum 36g, Herba Gendarussae 45g, Rhizoma Arisaematis 45g and Herba Artemisiae Anomalae 50g make.

Embodiment 3:

Pain bone-set plaster of the present invention, represents with weight g, by crude drug Stigma Croci 22g, Sanguis Draxonis 32g, Squama Manis 26g, Radix Notoginseng 55g, Radix Aconiti Preparata 42g, Radix Aconiti Kusnezoffii Preparata 42g, Ramulus Sambuci Williamsii 45g, Radix Clematidis 50g, Cortex Acanthopancis 48g, Rhizoma Drynariae 46g, Rhizoma Homalomenae 40g, Ramulus Cinnamomi 48g, Pyritum 45g, Herba Gendarussae 52g, Rhizoma Arisaematis 50g and Herba Artemisiae Anomalae 60g make.

Embodiment 4:

Pain bone-set plaster of the present invention, represents with weight g, by crude drug Stigma Croci 21g, Sanguis Draxonis 29g, Squama Manis 24g, Radix Notoginseng 52g, Radix Aconiti Preparata 40g, Radix Aconiti Kusnezoffii Preparata 36g, Ramulus Sambuci Williamsii 40g, Radix Clematidis 49g, Cortex Acanthopancis 47g, Rhizoma Drynariae 43g, Rhizoma Homalomenae 36g, Ramulus Cinnamomi 46g, Pyritum 38g, Herba Gendarussae 50g, Rhizoma Arisaematis 46g and Herba Artemisiae Anomalae 58g make.

Embodiment 5:

Pain bone-set plaster of the present invention, represents with weight g, by crude drug Stigma Croci 19g, Sanguis Draxonis 31g, Squama Manis 23g, Radix Notoginseng 48g, Radix Aconiti Preparata 36g, Radix Aconiti Kusnezoffii Preparata 40g, Ramulus Sambuci Williamsii 42g, Radix Clematidis 46g, Cortex Acanthopancis 46g, Rhizoma Drynariae 44g, Rhizoma Homalomenae 38g, Ramulus Cinnamomi 46g, Pyritum 42g, Herba Gendarussae 48g, Rhizoma Arisaematis 48g and Herba Artemisiae Anomalae 52g make.

Embodiment 6:

Pain bone-set plaster of the present invention, represents with weight g, by crude drug Stigma Croci 15g, Sanguis Draxonis 25g, Squama Manis 20g, Radix Notoginseng 40g, Radix Aconiti Preparata 30g, Radix Aconiti Kusnezoffii Preparata 30g, Ramulus Sambuci Williamsii 35g, Radix Clematidis 40g, Cortex Acanthopancis 40g, Rhizoma Drynariae 40g, Rhizoma Homalomenae 30g, Ramulus Cinnamomi 40g, Pyritum 30g, Herba Gendarussae 40g, Rhizoma Arisaematis 40g and Herba Artemisiae Anomalae 45g make.

Embodiment 7:

Pain bone-set plaster of the present invention, represents with weight g, by crude drug Stigma Croci 20g, Sanguis Draxonis 30g, Squama Manis 25g, Radix Notoginseng 50g, Radix Aconiti Preparata 40g, Radix Aconiti Kusnezoffii Preparata 40g, Ramulus Sambuci Williamsii 45g, Radix Clematidis 45g, Cortex Acanthopancis 45g, Rhizoma Drynariae 45g, Rhizoma Homalomenae 38g, Ramulus Cinnamomi 45g, Pyritum 38g, Herba Gendarussae 50g, Rhizoma Arisaematis 50g and Herba Artemisiae Anomalae 55g make.

Embodiment 8:

Pain bone-set plaster of the present invention, represents with weight g, by crude drug Stigma Croci 25g, Sanguis Draxonis 35g, Squama Manis 30g, Radix Notoginseng 60g, Radix Aconiti Preparata 45g, Radix Aconiti Kusnezoffii Preparata 45g, Ramulus Sambuci Williamsii 50g, Radix Clematidis 55g, Cortex Acanthopancis 50g, Rhizoma Drynariae 50g, Rhizoma Homalomenae 45g, Ramulus Cinnamomi 50g, Pyritum 45g, Herba Gendarussae 55g, Rhizoma Arisaematis 55g and Herba Artemisiae Anomalae 65g make.

Embodiment 9:

The boiling method of pain bone-set plaster described in embodiment of the present invention 1-8, its detailed step is as follows:

A, first take various crude drug according to the raw material composition and ratio ratio of the arbitrary described pain bone-set plaster of embodiment 1-8, for subsequent use;

B, the various crude drug mix homogeneously taken by step a, then pour in 2500g Oleum Sesami and heat, and after being heated to boiling, temperature being controlled to boil 60 minutes under 40 ~ 60 DEG C of conditions, boil in process and constantly stir, filter medicinal residues after boiling, obtain lubricate;

C, step b gained lubricate is heated to boiling, then slowly adds hydrargrum oxydatum crudum, the mass ratio that both plaster and hydrargrum oxydatum crudum add is 2:1, after adding hydrargrum oxydatum crudum, temperature is controlled to boil 1.5h under 40 ~ 60 DEG C of conditions, boils in process and constantly stir, obtain plaster after boiling;

D, the plaster obtained by step c are poured into water and soak 24h, pull out, are spread out on cloth, obtain pain bone-set plaster after immersion.

Claims (4)

1. a pain bone-set plaster, is characterized in that: represent with weight g, and described pain bone-set plaster is primarily of crude drug Stigma Croci 15 ~ 25g, Sanguis Draxonis 25 ~ 35g, Squama Manis 20 ~ 30g, Radix Notoginseng 40 ~ 60g, Radix Aconiti 30 ~ 45g, Radix Aconiti Kusnezoffii 30 ~ 45g, Ramulus Sambuci Williamsii 35 ~ 50g, Radix Clematidis 40 ~ 55g, Cortex Acanthopancis 40 ~ 50g, Rhizoma Drynariae 40 ~ 50g, Rhizoma Homalomenae 30 ~ 45g, Ramulus Cinnamomi 40 ~ 50g, Pyritum 30 ~ 45g, Herba Gendarussae 40 ~ 55g, Rhizoma Arisaematis 40 ~ 55g and Herba Artemisiae Anomalae 45 ~ 65g make.

2. pain bone-set plaster according to claim 1, is characterized in that: described pain bone-set plaster is primarily of crude drug Stigma Croci 18 ~ 22g, Sanguis Draxonis 28 ~ 32g, Squama Manis 22 ~ 26g, Radix Notoginseng 45 ~ 55g, Radix Aconiti 35 ~ 42g, Radix Aconiti Kusnezoffii 35 ~ 42g, Ramulus Sambuci Williamsii 38 ~ 45g, Radix Clematidis 45 ~ 50g, Cortex Acanthopancis 45 ~ 48g, Rhizoma Drynariae 42 ~ 46g, Rhizoma Homalomenae 35 ~ 40g, Ramulus Cinnamomi 45 ~ 48g, Pyritum 36 ~ 45g, Herba Gendarussae 45 ~ 52g, Rhizoma Arisaematis 45 ~ 50g and Herba Artemisiae Anomalae 50 ~ 60g make.

3. pain bone-set plaster according to claim 1 and 2, its feature exists: described Radix Aconiti is Radix Aconiti Preparata, and described Radix Aconiti Kusnezoffii is Radix Aconiti Kusnezoffii Preparata.

4. a boiling method for pain bone-set plaster, is characterised in that, described boiling method comprises the following steps:

A, first take various crude drug according to the raw material composition and ratio ratio of pain bone-set plaster described in claim 1 or 2, for subsequent use;

B, the various crude drug mix homogeneously taken by step a, then pour in 2000 ~ 3000g Oleum Sesami and heat, after being heated to boiling, temperature is controlled under 40 ~ 60 DEG C of conditions, boil 40 ~ 80 minutes, boil in process and constantly stir, after boiling, filter medicinal residues, obtain lubricate;

C, step b gained lubricate is heated to boiling, then slowly adds hydrargrum oxydatum crudum, the mass ratio that both plaster and hydrargrum oxydatum crudum add is 2:1, after adding hydrargrum oxydatum crudum, temperature is controlled under 40 ~ 60 DEG C of conditions, boil 1 ~ 1.5h, boil in process and constantly stir, after boiling, obtain plaster;

D, the plaster obtained by step c are poured into water immersion 20 ~ 24h, pull out after immersion, are spread out on cloth, obtain pain bone-set plaster.