CN105055670A - Green tea and carnitine capsule with function of reducing weight - Google Patents
Green tea and carnitine capsule with function of reducing weight Download PDFInfo
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- CN105055670A CN105055670A CN201510612279.3A CN201510612279A CN105055670A CN 105055670 A CN105055670 A CN 105055670A CN 201510612279 A CN201510612279 A CN 201510612279A CN 105055670 A CN105055670 A CN 105055670A
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Abstract
The invention discloses a green tea and carnitine capsule with the function of reducing weight. The green tea and carnitine capsule is characterized by being prepared in the following steps of taking a green tea extract with green tea as the raw material, adding L-carnitine tartrate, carrying out mixing, granulating, drying and straightening, then adding silicon dioxide and magnesium stearate, mixing the materials uniformly, then filling the mixture in a capsule and carrying out polishing, packaging and irradiation sterilization, thus preparing the green tea and carnitine capsule. The green tea and carnitine capsule has the beneficial effects that the green tea and carnitine capsule takes green tea and L-carnitine tartrate as the raw materials and organically combines the theory of traditional Chinese medicine with modern medicine to achieve the functions of removing fat and reducing weight; the traditional high-temperature green tea extraction method is changed, thus retaining the natural substances of fresh leaves; green tea hydrolysate obtained by adopting enzyme extraction is easy in control of molecular weight, has greenness and has strong activity and important biological functions, thus achieving the function of inhibiting obesity, especially visceral fat.
Description
Technical field
The invention belongs to technical field of health care food, particularly a kind of green tea carnitine capsule with weight losing function.
Background technology
Fat-reducing refers to use medicine, diet, motion, Chinese medicine meridian, psychotherapy reaches a kind of phenomenon reducing body fat and pile up, manage the improper activity that correction overweight people abnormal response causes, namely the characteristic sum type of sports of overweight people's trophic behavior is analyzed by behavioral science, based on this, the action of causeing fat rationally is revised.
The mortality rate of overweight people has than regular severe one and significantly increases, and along with the increase of body weight, mortality rate also increases to some extent.Research shows, because of diabetes, died obviously increases as 38.3%(male than regular restructuring overweight people) and 37.2%(women); Next is the mortality rate of liver cirrhosis, appendicitis, Patients with Cholelithiasis, about overweight people also doubles; The mortality rate of cardiovascular, nephropathy and contingency is also higher.It is higher than non-obese person that overweight people suffers from hypertensive probability.Overweight people often increases with cardiac output and blood volume, but normotensive overweight people, peripheral vascular resistance reduces, and has hypertensive overweight people's peripheral vascular resistance normal or raise.Hypertension is the key factor of obesity high mortality.
Current medical science viewpoint, it is disease that obesity is not really, and is but the common worry of many people.Medical research is thought simultaneously, when inside of human body lacks a kind of material of green light element by name, the adjustment of blood sugar for human body, fat and energy can be caused disorderly, then bring out and cause fat; When the green light plain concentration in human body remains on normal level, the body weight of people just recovers normal.There are many ways of preventing obesities on the market, such as, keep fit through sport, but be not all effective to everyone.Some people has successfully deducted fat meat, and spirit is eased up soon, and people is fat again to go back.Current medical circle does not still have desirable Weight-reducing health medicine, and some medicine even has obvious side effect, damages human body other system or organ, and comprehensive therapeutic effect function is not strong, and rehabilitative action is also significantly little, perfect still not to the utmost.
summary of the invention:
The object of the invention is to provide a kind of green tea carnitine capsule with weight losing function, the constant product quality making to obtain, controlled, edible safety, there is significant health-care effect, and industrial production cost is low, has good market development application prospect.
For achieving the above object, the present invention adopts following technical scheme:
A kind of green tea carnitine capsule with weight losing function, it is characterized in that being that green tea extract made by raw material with green tea, add L-carnitine-L-tartrate, through mixing, granulate, dry, granulate, add silicon dioxide again, magnesium stearate is mixed evenly, then incapsulate, polishing, packaging, irradiation sterilization make, the percentage by weight of each component is: green tea extract 70-90%, L-carnitine-L-tartrate 10-30%, silicon dioxide 0.1-2%, magnesium stearate 0.1-2%.
Described green tea extract is that raw material is destemming with green tea, removing silt, foreign material, then through cleaning, rubbings, defibrination, degraded, ultrafiltration, concentrate, spraying dry makes.
Fresh green tea selected by described green tea.
Described rubbing is rubbed at green tea tissue mashing machine.
Described defibrination is sent in colloid mill by the green tea after rubbing, and adds 1 ~ 3 times of purifying waste water to raw material and carry out defibrination.
Described degraded is that the green tea serosity of defibrination is put into reactor, adds water 3 ~ 7 times, is heated to 37 ~ 52 DEG C, add 0.1% ~ 1% compound enzyme, and constant temperature stirs after 3 ~ 5 hours and is warming up to 90 DEG C of enzyme denaturing.
Described ultrafiltration be by degradation treatment after green tea serosity adopt ultrafiltration membrane technique molecular cut off section below 5000 dalton.
Described mix homogeneously adopts conventional method, and obtained green tea extract is added L-carnitine-L-tartrate mix homogeneously, and incorporation time is for being no less than 30 minutes.
Described granulation, concentrated, spraying dry, granulate, mixing, encapsulated, polishing, packaging all adopt Conventional processing methods.
Starting silica in instant component, magnesium stearate can be chosen in market, and domestic and international market is sold all to some extent.
Green tea in raw material components of the present invention is rich in the closely-related biochemical with health, Folium Camelliae sinensis not only have refresh oneself clear away heart-fire, clearing away summer-heat, eliminate indigestion and phlegm, fat-reducing slimming, the relieving restlessness that clears away heart-fire, pharmacological action such as removing toxic substances relieving alcoholic intoxication, promoting the production of body fluid to quench thirst, pathogenic fire reducing improving eyesight, dysentery relieving dehumidifying etc., also to modern diseases, as diseases such as Radiation sickness, cardiovascular and cerebrovascular disease, cancers, there is certain pharmacological effect.Green tea can help improve dyspepsia, has the harvesting green tea of " food of a specified duration makes us thin " to record in the Tang Dynasty supplement to the Herbal to effect of tea.What China's borderland ethnic groups had " can not one day without tea " says.Because Folium Camelliae sinensis has aid digestion and falls low-fat important effect, say with current fashion language, contribute to exactly " fat-reducing ".This is because the caffeine in Folium Camelliae sinensis can improve the secretory volume of gastric juice, can help digest, strengthen lipolytic ability.
L-carnitine-L-tartrate in raw material components of the present invention promotes that adipose conversion becomes energy, is safer one fat-reducing supplement, and L-carnitine is a kind of adipose conversion that impels is the amino acid of energy, to human non-toxic's side effect.Be particularly suitable for people's cooperation and do aerobatic exercise fat reducing.Effectiveness comparison is obvious, and fat unnecessary in incendivity body is as energy.He can lose weight, and reduces the content of body fat, has antiobesity action, often supplements L-carnitine, is kept taking exercise, just can consume the fatty acid of cylinder accumulation, play the effect of fat-reducing.So L-carnitine is a kind of very desirable need not going on a diet, not anorexia, not weak, the diet products of not suffering from diarrhoea.
Capsule of the present invention has steady quality, bioavailability advantages of higher, compares with pill with tablet, and hard capsule in the gastrointestinal tract disintegrate is very fast, effective fast, good absorbing, bioavailability are high, and can moistureproof, lucifuge, stable in properties, be convenient to preserve, extend release of active agent.
The present invention with green tea, L-carnitine-L-tartrate for raw material, organically combine with theory of Chinese medical science and modern medicine, play effect of fat-reducing slimming altogether, traditional high temperature extraction method has been abandoned in the extracting method pick of green tea, remain the natural materials of fresh leaf, adopt Enzymatic Extraction to obtain easy to control, the product self of green tea hydrolysate molecular weight be rich in green attribute, have extremely strong activity and important biological function, the tea polyphenols be rich in, catechin, chlorophyll, caffeine, aminoacid, vitamins and other nutritious components retain perfect.These natural nutrition compositions in green tea can add excitometabolic, strengthen the oxidation of fat and energy expenditure thus reach to suppress fat effect, especially to the inhibitory action of interior fat.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
Gather and select fresh green tea raw material, destemmingly remove silt, foreign material, rubbing through tissue mashing machine after cleaning sends in colloid mill again, add 2 times of purifying waste water to raw material and carry out defibrination, again the serosity of defibrination is put into reactor, add water 5 times, add 0.5% compound enzyme, initial segment is heated to 41 DEG C, one hour post-heating to 52 DEG C, constant temperature is warming up to 90 DEG C of enzyme denaturing after stirring 3 hours, adopted by serosity after degradation treatment ultrafiltration membrane technique molecular cut off section again below 5000 dalton, heating is concentrated into 55 DEG C of heat survey relative densities is again the magma of 1.25, then freeze-drying is adopted to carry out, be dried to moisture 5%, green tea hydrolysate 9 kilograms is made in drying, for subsequent use,
Buying takes L-carnitine-L-tartrate 1.3 kilograms, silicon dioxide 0.4 kilogram, magnesium stearate 0.3 kilogram, for subsequent use;
By green tea hydrolysate 9 kilograms, L-carnitine-L-tartrate 1.3 kilograms of mix homogeneously, incorporation time is for being no less than 30 minutes, by mixed material pelletization, drying, granulate, silicon dioxide 0.4 kilogram is added again in dried particles, magnesium stearate 0.3 kilogram, mix homogeneously, then incapsulates, polishing, packaging, irradiation sterilization makes capsule preparations of the present invention.
Embodiment 2:
Gather and select fresh green tea raw material, destemmingly remove silt, foreign material, rubbing through tissue mashing machine after cleaning sends in colloid mill again, add 2 times of purifying waste water to raw material and carry out defibrination, again the serosity of defibrination is put into reactor, add water 5 times, add 0.1% compound enzyme, initial segment is heated to 41 DEG C, one hour post-heating to 52 DEG C, constant temperature is warming up to 90 DEG C of enzyme denaturing after stirring 4 hours, adopted by serosity after degradation treatment ultrafiltration membrane technique molecular cut off section again below 5000 dalton, heating is concentrated into 55 DEG C of heat survey relative densities is again the magma of 1.25, then freeze-drying is adopted to carry out, be dried to moisture 5%, green tea hydrolysate 9 kilograms is made in drying, for subsequent use,
Buying takes L-carnitine-L-tartrate 1.3 kilograms, silicon dioxide 0.4 kilogram, magnesium stearate 0.3 kilogram, for subsequent use;
By green tea hydrolysate 9 kilograms, L-carnitine-L-tartrate 1.3 kilograms of mix homogeneously, incorporation time is for being no less than 30 minutes, by mixed material pelletization, drying, granulate, silicon dioxide 0.4 kilogram is added again in dried particles, magnesium stearate 0.3 kilogram, mix homogeneously, then incapsulates, polishing, packaging, irradiation sterilization makes capsule preparations of the present invention.
Embodiment 3
The present invention sets forth the beneficial effect of described product further by human experiment experiment, and test carries out according to the evaluation test method of weight losing function in " health food inspection and assessment technical specification ".
Weight losing function human feeding trial provided by the invention is reported as follows:
1 materials and methods
1.1 samples: green tea carnitine capsule No.1 of the present invention, No. 2, provide by the present inventor, the two is basically identical in packaging, outward appearance, color and luster and mouthfeel, one of them is green tea carnitine capsule of the present invention, another is placebo, and human oral's recommended dose is every day 3 times, each 2.
1.2 study subjects:
Experimenter's male or female, Simple Obesity, through health check-up, without dysfunctions such as the obvious heart, liver, gallbladder, kidneys.
1.2.1 experimenter's choice criteria:
Adult BMI >=30, or total fat percentage reaches male >25%, the volunteer of female >30%.
1.2.2 exclusion standard:
1.2.2.1 merge intentionally, liver, the serious disease such as kidney and hemopoietic system, psychotic.
1.2.2.2 take the article relevant with tested function in a short time, have influence on the judgement person to result.
1.2.2.3 not by the edible tested material of regulation, effect or data not umbra sound effect or safety judgement person cannot be judged.
1.3 test methods: will inclusive criteria be met and ensure the volunteer of compatibility test, being divided into test-meal group and matched group at random.Test-meal group and matched group take by recommended dose the sample that producer provides, continuous 45 days.Duration of test does not change original dietary habit, normal diet.Test-meal test is carried out by blind.
1.4 key instruments: Sebum thickness measurer, body composition analysis instrument, cycle ergometer.
2. observation index: indices starts in test-meal experiment and terminates each test once.
2.1 safety observations:
2.1.1 ordinary circumstance: spirit, sleep, diet, defecation, blood pressure, heart rate etc.
2.1.2 Blood routine examination: red blood cell count(RBC), hemoglobin, numeration of leukocyte.
2.1.3 routine urinalysis (comprising urine ketoboidies) and stool routine examination.
2.1.4 Biochemical Indexes: albumin (ALB), total protein (TP), glutamic oxaloacetic transaminase, GOT (AST), glutamate pyruvate transaminase (ALT), blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), blood glucose (GLU), triglyceride (TG), T-CHOL (CHOL) etc.
2.1.5 Abdominal B type ultrasonography, electrocardiogram, x-ray fluoroscopy of chest.
2.1.6 exercise tolerance test: exercise tolerance method of testing is cycle ergometer test
Before and after test-meal, experimenter is with identical motion scheme power cycle test, recorded heart rate, and applies the maximal oxygen uptake (L/ divides) of each experimenter of nomography indirect determination of Astrand and Ryhming.
2.1.7 other untoward reaction are observed.
2.2 dietary factors and motion conditions are observed.
2.3 efficiency index
2.3.1 body weight and height: emptying defecation before measuring, takes off one's shoes, and the timing of resurveying of test-meal forebody-afterbody is all worn same clothes and measured in same scale.
2.3.2 bioelectrical impedance analysis: measure human body body fat rate.
2.3.3 girth diameter measures:
2.3.3.1 waistline: the abdomen girth of flat umbilicus.
2.3.3.2 hip circumference: the girth of existing both sides greater trochanter of femur level.
2.3.4. stratum corneum lipids measures: measurement site
2.3.4.1 mid-point outside right triangular muscle lower edge arm.
2.3.4.2 right angulus inferior scapulae.
2.3.4.3 the other 3cm of right umbilicus
2.3.4.4 right anterior superior iliac spine.
2.4 experimental data statistics: carry out statistical analysis with INSTA software.
3, result
Double-blind method observation end is made known:
Take No. 2 persons for placebo,
Take No. 1 person for green tea carnitine capsule of the present invention.
3.1 ordinary circumstances:
Initial trial crowd test-meal group 53 example, matched group 53 example.Before and after test-meal test, experimenter's spirit, sleep, diet, defecation situation no abnormality seen.
Matched group: male/female is 42/11, the age is 41.75 ± 10.37 years old;
Test-meal group: male/female is 42/11, the age is 42.57 ± 11.09 years old.
3.2 safety observations Indexs measure
3.2.1 blood pressure heart rate routine urinalysis, stool routine examination, blood routine and Biochemical Indexes:
Table 1 blood pressure heart rate routine urinalysis, stool routine examination, blood routine and biochemical indicator survey result
From table 1, before and after test-meal, indices is all within normal range.
3.2.2 Abdominal B type ultrasonography, electrocardiogram, x-ray fluoroscopy of chest detects; All in normal range.
3.2.3 obvious adverse reaction is had no during test-meal
3.2.4 the change of maximal oxygen uptake and main nutrients intake.
The maximum amount of conserving one's health and Major Nutrient intake before and after table 2 green tea carnitine capsule weight losing function human experiment
From table 2, maximal oxygen uptake and the main nutrients intake of test front and back experimenter have no significant change.
3.2.5 the moving situation of test front and back experimenter is without significant change
3.3 both effectiveness observation index
3.3.1 body weight, body fat gross weight and fat percentage measure
Body weight, body fat total amount and fat percentage measurement result before and after the test-meal of table 3 green tea carnitine capsule
Note: * with compare p<0.05# before test-meal and compare p<0.05 with matched group
Before test, matched group and test-meal group body weight, body fat gross weight, Rate of body lipid level compare, and P value is all greater than 0.05, points out between two groups and has comparability.After test, test-meal group experimenter comparatively tests front weight average decline 1.37kg, and the total galassing of body fat increases decline 1.17kg, and Rate of body lipid on average declines 0.91%.After test, body weight has no obvious change (P>0.05).Test rear test-meal group subject fat gross weight and Rate of body lipid and matched group and self test front comparing difference and have significance (P<0.05).
3.3.2 subcutaneous fat thickness measure
Subcutaneous fat thickness measuring result before and after 4 table green tea carnitine capsule test-meals
Note: * with compare p<0.05# before test-meal and compare p<0.05 with matched group
After test, test-meal group experimenter comparatively tests the decline of front subcutaneous fat thickness, and wherein triangular muscle place reduces 1.08mm, and under omoplate, place subtracts not 0.59mm, and the other place of umbilicus reduces 0.61mm, ilium sour jujube place minimizing 1.09mm.After test, on test-meal experimenter triangular muscle place and ilium sour jujube place skin, fat thickness compares with before test, all has significance (P<0.05) with matched group comparing difference, locates subcutaneous fat thickness and matched group comparing difference without significance (P>0.05) under the other place of umbilicus and omoplate.
3.3.3 girth diameter measurement result
Girth diameter measurement result before and after 5 table green tea carnitine capsule test-meals
Note: * with compare p<0.05# before test-meal and compare p<0.05 with matched group
After test, test-meal group experimenter comparatively tests front waistline minimizing 2.09cm, and hip circumference reduces 1.03cm.Test rear test-meal group experimenter's waistline and matched group and self test front comparing difference and have significance (p<0.05), after test, test-meal group experimenter hip circumference compares there was no significant difference (p>0.05) before testing with matched group and self.
3.3.4 depigmentation rate
After test in 45 days, matched group has 0 routine experimenter cannot judge that effect is screened out because being interrupted to take by test product; Test-meal group has 0 routine experimenter cannot judge that effect is screened out because being interrupted to take by test product.Last efficiency test crowd matched group 53 example, test-meal group 53 example, in table 6.
Depigmentation rate tested by table 6
| Group | Matched group (example) | Test-meal group (example) |
| Before test-meal | 53 | 53 |
| Depigmentation number | 0 | 0 |
| Depigmentation rate | 0.00% | 0.00% |
4, brief summary
Experimenter's edible green tea carnitine capsule of the present invention 45 days continuously, except 1.37kg under test-meal group weight average, body fat gross weight on average declines 1.17kg, and Rate of body lipid is on average lower to 0.91%; Subcutaneous fat thickness does not all fall, and wherein triangular muscle place reduces 1.08mm, and under omoplate, place subtracts not 0.59mm, and the other place of umbilicus reduces 0.61mm, and ilium sour jujube place reduces 1.09mm.Waistline reduces 2.09cm, and hip circumference reduces 1.03cm.After the test of test-meal group body weight, Rate of body lipid, two place's subcutaneous fat thicknesses (triangular muscle place, ilium sour jujube place) waistline and matched group and before self test comparing difference have that significance (p<0.050) umbilicus is other locate and locate under omoplate subcutaneous fat thickness and matched group comparing difference without significance (P>0.05), and self test front comparing difference and test rear body weight hip circumference index without significant change (P>0.05) without significance (P>0.05) test-meal group.Test-meal group and in matched group experimenter every safety observations index equal normal range before and after test, has no obvious adverse reaction during test-meal.Study subject exercise tolerance and appetite have no decline.According to " health food inspection and assessment technical specification " evaluation criterion, prompting green tea carnitine capsule has antiobesity action to human body.
Claims (4)
1. one kind has the green tea carnitine capsule of weight losing function, it is characterized in that being that green tea extract made by raw material with green tea, add L-carnitine-L-tartrate, through mixing, granulate, dry, granulate, add silicon dioxide again, magnesium stearate is mixed evenly, then incapsulate, polishing, packaging, irradiation sterilization make, the percentage by weight of each component is: green tea extract 70-90%, L-carnitine-L-tartrate 10-30%, silicon dioxide 0.1-2%, magnesium stearate 0.1-2%.
2. a kind of green tea carnitine capsule with weight losing function according to claim 1, it is characterized in that described green tea extract is is that raw material is destemming with green tea, removing silt, foreign material, then through cleaning, rubbings, defibrination, degraded, ultrafiltration, concentrate, spraying dry makes.
3. a kind of green tea carnitine capsule with weight losing function according to claim 1, it is characterized in that described degraded is that the green tea serosity of defibrination is put into reactor, add water 3 ~ 7 times, be heated to 37 ~ 52 DEG C, add 0.1% ~ 1% compound enzyme, constant temperature stirs after 3 ~ 5 hours and is warming up to 90 DEG C of enzyme denaturing.
4. a kind of green tea carnitine capsule with weight losing function according to claim 1, it is characterized in that described ultrafiltration be by degradation treatment after green tea serosity adopt ultrafiltration membrane technique molecular cut off section below 5000 dalton.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108095113A (en) * | 2017-12-22 | 2018-06-01 | 成都博创必成医药技术有限公司 | A kind of composition, preparation and its application with fat reducing blood sugar reducing function |
| CN108450951A (en) * | 2018-02-06 | 2018-08-28 | 芜湖市诺康生物科技有限公司 | A kind of weight-reducing fat reducing capsule and preparation method thereof |
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| CN1742595A (en) * | 2004-08-30 | 2006-03-08 | 长谷川香料株式会社 | Packed green tea drink |
| CN102438642A (en) * | 2009-05-19 | 2012-05-02 | 株式会社爱茉莉太平洋 | Composition comprising green tea extract |
| CN103610054A (en) * | 2013-11-27 | 2014-03-05 | 营养屋(成都)生物医药有限公司 | Healthcare food with effects of reducing weight and facilitating feces excretion and preparation method thereof |
| CN104415188A (en) * | 2013-08-19 | 2015-03-18 | 宣城柏维力生物工程有限公司 | L-carnitine tea polyphenol capsule and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742595A (en) * | 2004-08-30 | 2006-03-08 | 长谷川香料株式会社 | Packed green tea drink |
| CN102438642A (en) * | 2009-05-19 | 2012-05-02 | 株式会社爱茉莉太平洋 | Composition comprising green tea extract |
| CN104415188A (en) * | 2013-08-19 | 2015-03-18 | 宣城柏维力生物工程有限公司 | L-carnitine tea polyphenol capsule and preparation method thereof |
| CN103610054A (en) * | 2013-11-27 | 2014-03-05 | 营养屋(成都)生物医药有限公司 | Healthcare food with effects of reducing weight and facilitating feces excretion and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108095113A (en) * | 2017-12-22 | 2018-06-01 | 成都博创必成医药技术有限公司 | A kind of composition, preparation and its application with fat reducing blood sugar reducing function |
| CN108450951A (en) * | 2018-02-06 | 2018-08-28 | 芜湖市诺康生物科技有限公司 | A kind of weight-reducing fat reducing capsule and preparation method thereof |
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