CN108450951A - A kind of weight-reducing fat reducing capsule and preparation method thereof - Google Patents
A kind of weight-reducing fat reducing capsule and preparation method thereof Download PDFInfo
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- CN108450951A CN108450951A CN201810119350.8A CN201810119350A CN108450951A CN 108450951 A CN108450951 A CN 108450951A CN 201810119350 A CN201810119350 A CN 201810119350A CN 108450951 A CN108450951 A CN 108450951A
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- weight
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- reducing
- tea polyphenols
- fat reducing
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- 239000002775 capsule Substances 0.000 title claims abstract description 41
- 230000001603 reducing effect Effects 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 30
- 241001122767 Theaceae Species 0.000 claims abstract description 28
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 27
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 27
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 26
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 15
- 239000008101 lactose Substances 0.000 claims abstract description 15
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 15
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 13
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 14
- 239000012528 membrane Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 9
- 239000011812 mixed powder Substances 0.000 claims description 9
- 238000001291 vacuum drying Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000011049 filling Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 238000012856 packing Methods 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- 238000007689 inspection Methods 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 230000003139 buffering effect Effects 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- 235000019580 granularity Nutrition 0.000 claims description 3
- 239000007902 hard capsule Substances 0.000 claims description 3
- 238000002386 leaching Methods 0.000 claims description 3
- 239000011259 mixed solution Substances 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 229920002492 poly(sulfone) Polymers 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 238000000120 microwave digestion Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 14
- 238000005516 engineering process Methods 0.000 abstract description 7
- 230000036541 health Effects 0.000 abstract description 4
- 235000013305 food Nutrition 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 235000019197 fats Nutrition 0.000 description 20
- 235000013361 beverage Nutrition 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 210000000577 adipose tissue Anatomy 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 240000002853 Nelumbo nucifera Species 0.000 description 2
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 2
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 208000005374 Poisoning Diseases 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 235000013353 coffee beverage Nutrition 0.000 description 2
- 230000000368 destabilizing effect Effects 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 1
- 240000004510 Agastache rugosa Species 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000003579 anti-obesity Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 235000021539 instant coffee Nutrition 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention discloses a kind of formulas of weight-reducing fat reducing capsule, are related to medicines and health protection food technology field, contain following component：80 100 parts by weight of L-carnitine-L-tartrate, 60 80 parts by weight of tea polyphenols, 10 20 parts by weight of 5 10 parts by weight of lactose, 0 20 parts by weight of silica 1 and magnesium stearate.In addition, the invention also discloses the preparation methods of the weight-reducing fat reducing capsule.The weight-reducing fat reducing capsule of the present invention, supplementary material have collaboration enhancement effect, and compared with prior art, dosage science, effect of weight reducing are good, and have healthcare function, have no toxic side effect.Preparation method rational technology, operability is strong, easily accomplishes scale production.
Description
Technical field
The present invention relates to medicines and health protection food technology fields, and in particular to a kind of weight-reducing fat reducing capsule and preparation method thereof.
Background technology
Obesity refers to a degree of apparent overweight blocked up with fat deposit, is body fat, especially triglycerides gathers
A kind of state caused by excessive.Body fat accumulation is caused excessively to be made since food intake is excessive or the change of organism metabolism
Increase and cause human pathology, physiological change or latent at excess weight.Pre- preventing obesity early is very important.
Chinese Patent Application No. 201410509050.2 discloses a kind of containing tea polyphenols, l-cn and Lotus Leafextract
Beverage, constituent include (100 bottles of amounts, 100ml/ bottles)：20-30 parts of tartaric acid l-cn, 4-6 parts of tea polyphenols, lotus leaf
0.45-0.55 parts of extract, 100-200 parts of filler, 5-10 parts of sweetener, 5-10 parts of preservative, 6-8 parts of food flavor,
Surplus is supplied using purified water.Compound l-cn beverage mouthfeel prepared by the invention is good, carries and convenient to take, is suitable for
A variety of crowds are edible, and can play certain lipid-loweringing, antiobesity action.But it is lost weight, fat reducing effect is not necessarily so bright
It is aobvious.
Chinese Patent Application No. 201710586499.2 discloses a kind of fine l-cn coffee solid beverage of evil spirit, by quality
Percentage is made of following raw material：Konjaku flour 2-5%, instant coffee powder 40-55%, l-cn 1-3%, vegetable fat powder 8-
12%, oligofructose 30-35%, wrinkled giant hyssop 1-3%.The invention compared with prior art the advantages of be：The evil spirit of the invention is fine left-handed
Carnitine coffee solid beverage, which has, promotes adipose conversion not reduce moisture while reducing body fat, losing weight at energy
And muscle, safety slimming health product without side-effects.But caffeine excessively eats the health for being unfavorable for human body.
Invention content
It is caused by the prior art to solve the purpose of the present invention is to provide a kind of preparation method of weight-reducing fat reducing capsule
Drawbacks described above.
The present invention is achieved through the following technical solutions, a kind of formula of weight-reducing fat reducing capsule, by weight, including：
Preferably, a kind of formula of weight-reducing fat reducing capsule, by weight, including：
A kind of preparation method of weight-reducing fat reducing capsule, includes the following steps：
(1) it learns from else's experience and examines qualified L-carnitine-L-tartrate, tealeaves, lactose, silica and magnesium stearate will be former
Auxiliary material removes outer packing, and inner packing is by entering clean area between buffering；
(2) it extracts：Tealeaves is obtained into tea polyphenols with microwave―assisted extraction and low-temperature vacuum drying method；
(3) it is sieved：L-carnitine-L-tartrate, lactose, silica and Magnesium Stearate is spare；
(4) it weighs：L-carnitine-L-tartrate, tea polyphenols, lactose, silica and stearic acid are weighed by formula rate
Magnesium is spare；
(5) one is mixed：By load weighted L-carnitine-L-tartrate, the multidirectional three-dimensional motion mixer mixing 50- of tea polyphenols
60min；
(6) two is mixed：Load weighted lactose, silica and magnesium stearate mixing 30- is added in step (5) mixed powder
40min obtains total mixed powder；
(7) filling capsule：By total filling capsule of mixed powder automatic hard capsule filler, capsule, 1.0g-1.4g/ are obtained
Grain；
(8) it polishes, select：Remove the powder of capsule surface；Remove underproof product；
(9) packaging, quality inspection, storage.
Preferably, clean area humiture described in the step (1) is respectively 40 DEG C -45 DEG C, and 40%.
Preferably, steps are as follows for the microwave―assisted extraction in the step (2)：
(1) it is 80 mesh granularities to crush tealeaves, using aqueous solution as leaching agent, the mass ratio 1 of tealeaves and water:25；
(2) 10-15g Tea Samples are contained with 500mL triangular flasks and water is placed in micro-wave oven and carries out microwave digestion, microwave work(
Rate is adjusted to 600W；
(3) Extracting temperature is 68 DEG C, 3 hours extraction times, obtains mixed solution；
(4) tea polyphenols are separated using ultra-filtration and separation, obtains tea polyphenols just extracting solution, condition is hollow-fibre membrane, material
Material is polysulfones, and membrane aperture is between 0.0015-0.02 μm, membrane tube quantity 182, pipe range 26.3cm, single tube outer diameter 2.5mm, single
Bore 1.5mm, total membrane area 0.242m2, molecular cut off:30000D, operating pressure：0.08-0.14Mpa；Temperature≤60
℃。
Preferably, steps are as follows for low-temperature vacuum drying method in the step (2)：
(1) extracting solution at the beginning of tea polyphenols is put into vacuum freeze drier, is vacuumized；
(2) drying time is 12-24 hours, obtains tea polyphenols.
Using above technical scheme, compared with prior art, the present invention has the following advantages：
L-carnitine-L-tartrate, tealeaves, lactose, silica and magnesium stearate have collaboration enhancement effect, with show
There is technology to compare, dosage science, effect of weight reducing are good, and have healthcare function, have no toxic side effect.Preparation method rational technology,
Operability is strong, easily accomplishes scale production, and whole collinear processing, avoids nutrition leak caused by destabilizing factor；
The tea polyphenols are made by microwave―assisted extraction and low-temperature vacuum drying method, can effectively ensure that tea polyphenol extract rate reaches
To highest, loss is minimized；Entire preparation process completes in certain clean area, ensure that the cleaning of working environment, most
Influence of the reduction environment of big degree to capsule.
Specific implementation mode
To make the technical means, creative features, achievement of purpose and effectiveness of the invention easy to understand, with reference to specific
Embodiment, the present invention is further explained.
Embodiment 1
A kind of formula of weight-reducing fat reducing capsule, by weight：
Embodiment 2
A kind of formula of weight-reducing fat reducing capsule, by weight：
Embodiment 3
A kind of formula of weight-reducing fat reducing capsule, by weight：
Embodiment 4
A kind of formula of weight-reducing fat reducing capsule, by weight：
Embodiment 5
A kind of formula of weight-reducing fat reducing capsule, by weight：
It is worth noting that, in embodiment 1-5, the preparation method of making weight-reducing fat reducing capsule described above, including
Following steps：
(1) it learns from else's experience and examines qualified L-carnitine-L-tartrate, tealeaves, lactose, silica and magnesium stearate will be former
Auxiliary material removes outer packing, and inner packing is by entering clean area between buffering；
(2) it extracts：Tealeaves is obtained into tea polyphenols with microwave―assisted extraction and low-temperature vacuum drying method；
(3) it is sieved：L-carnitine-L-tartrate, lactose, silica and Magnesium Stearate is spare；
(4) it weighs：L-carnitine-L-tartrate, tea polyphenols, lactose, silica and stearic acid are weighed by formula rate
Magnesium is spare；
(5) one is mixed：By load weighted L-carnitine-L-tartrate, the multidirectional three-dimensional motion mixer mixing 50- of tea polyphenols
60min (preferably 55min)；
(6) two is mixed：Load weighted lactose, silica and magnesium stearate mixing 30- is added in step (5) mixed powder
40min (preferably 35min), obtains total mixed powder；
(7) filling capsule：By total filling capsule of mixed powder automatic hard capsule filler, capsule, 1.0g-1.4g/ are obtained
Grain；
(8) it polishes, select：Remove the powder of capsule surface；Remove underproof product；
(9) packaging, quality inspection, storage.
Furthermore it should be noted that clean area humiture described in the step (1) is respectively 40 DEG C -45 DEG C (preferably
40 DEG C), 40%.Steps are as follows for microwave―assisted extraction in the step (2)：
(1) it is 80 mesh granularities to crush tealeaves, using aqueous solution as leaching agent, the mass ratio 1 of tealeaves and water:25；
(2) 10-15g (preferably 12g) Tea Samples are contained with 500mL triangular flasks and water is placed in micro-wave oven and carries out microwave
Extraction, microwave power are adjusted to 600W；
(3) Extracting temperature is 68 DEG C, 3 hours extraction times, obtains mixed solution；
(4) tea polyphenols are separated using ultra-filtration and separation, obtains tea polyphenols just extracting solution, condition is hollow-fibre membrane, material
Material is polysulfones, and for membrane aperture between 0.0015-0.02 μm (preferably 0.01 μm), membrane tube quantity 182, pipe range 26.3cm is single
Pipe outside diameter 2.5mm, single tube internal diameter 1.5mm, total membrane area 0.242m2, molecular cut off:30000D, operating pressure：0.08-
0.14Mpa (preferably 0.12Mpa)；Temperature≤60 DEG C.
Steps are as follows for low-temperature vacuum drying method in the step (2)：
(1) extracting solution at the beginning of tea polyphenols is put into vacuum freeze drier, is vacuumized；
(2) drying time is 12-24 hours (preferably 18 hours), obtains tea polyphenols.
Acute toxicity test in mice：
Using maximum tolerated dose method, it is the Kunming mouse 20 of 18-22g, half male and half female to select weight.Take the present invention
Weight-reducing fat reducing capsule 's content 50g adds 1% sodium carboxymethylcellulose to 100mL.It is spaced in one day 4 hours and oral fills to mouse
Stomach 2 times, each gavage volume are 0.2mL/10g.bw, intergal dose 20.00g/kg.bw.Fasting 16 hours before gavage for the first time,
It is observed continuously after gavage two weeks, records poisoning manifestations and death condition.Experimental result is as follows：
| Gender | Number of animals (only) | Approach | Dosage (g/kg.bw) | Death toll (only) | MTD(g/kg.bw) |
| It is female | 10 | Orally | 20 | 0 | >20.00 |
| It is male | 10 | Orally | 20 | 0 | >20.00 |
The Kunming kind of two kinds of genders is given with the weight-reducing fat reducing capsule 's content of the inventive samples of 20.00g/kg.bw dosage
Apparent poisoning symptom is had no after intragastric administration on mice, observes 14 days without death.Animal subject execution is carried out dissection inspection by the observation end of term,
The main organs such as liver,spleen,kidney, stomach, intestines, the heart, lung show no obvious abnormalities change.Illustrate present invention weight-reducing fat reducing capsule to Kunming
Kind mouse male and female mouse maximal tolerance dose is more than 20.00g/kg.bw, belongs to nontoxic grade.
Effect experiment
Weight-reducing fat reducing capsule effect that embodiment 1-5 is produced is evaluated following with edible rear effect.Pass through 60 fertilizer
The volunteer of fat disease patient is arbitrarily divided into 6 groups as object is tried out, and eats weight-reducing fat reducing glue prepared by embodiment 1-5 respectively
Capsule and blank control group are eaten one month once a day, and effect total score is 5 points：5 points are best result, indicate fine, very
It is satisfied；4 points are preferable；3 points are that can receive；3 points or less are bad, cannot be received.It is every average below.
| Object | Therapeutic effect average |
| Embodiment 1 | 4.9 |
| Embodiment 2 | 4.8 |
| Embodiment 3 | 4.8 |
| Embodiment 4 | 4.6 |
| Embodiment 5 | 4.8 |
| Blank group | 2.7 |
In conclusion there is collaboration to promote for L-carnitine-L-tartrate, tealeaves, lactose, silica and magnesium stearate
Effect, compared with prior art, dosage science, effect of weight reducing are good, and have healthcare function, have no toxic side effect.Preparation method
Rational technology, operability is strong, easily accomplishes scale production, and whole collinear processing, caused by avoiding destabilizing factor
Nutrition leak；The tea polyphenols are made by microwave―assisted extraction and low-temperature vacuum drying method, can effectively ensure that tea is more
Phenol extraction rate reaches highest, and loss is minimized；Entire preparation process completes in certain clean area, ensure that working environment
Cleaning, reduce influence of the environment to capsule to the greatest extent.
As known by the technical knowledge, the present invention can pass through the embodiment party of other essence without departing from its spirit or essential feature
Case is realized.Therefore, embodiment disclosed above, all things considered are all merely illustrative, not the only.Institute
Have within the scope of the present invention or is included in the invention in the change being equal in the scope of the present invention.
Claims (6)
1. a kind of formula of weight-reducing fat reducing capsule, which is characterized in that by weight, including：
。
2. a kind of formula of weight-reducing fat reducing capsule according to claim 1, which is characterized in that by weight, including：
。
3. the preparation method of the weight-reducing fat reducing capsule according to any one of claim 1-2, which is characterized in that including as follows
Step：
(1) it learns from else's experience and examines qualified L-carnitine-L-tartrate, tealeaves, lactose, silica and magnesium stearate by supplementary material
Outer packing is removed, inner packing is by entering clean area between buffering；
(2) it extracts：Tealeaves is obtained into tea polyphenols with microwave―assisted extraction and low-temperature vacuum drying method；
(3) it is sieved：L-carnitine-L-tartrate, lactose, silica and Magnesium Stearate is spare；
(4) it weighs：It is standby that L-carnitine-L-tartrate, tea polyphenols, lactose, silica and magnesium stearate are weighed by formula rate
With；
(5) one is mixed：By load weighted L-carnitine-L-tartrate, the multidirectional three-dimensional motion mixer mixing 50- of tea polyphenols
60min；
(6) two is mixed：Load weighted lactose, silica and magnesium stearate mixing 30-40min is added in step (5) mixed powder,
Obtain total mixed powder；
(7) filling capsule：By total filling capsule of mixed powder automatic hard capsule filler, capsule is obtained, 1.0g-1.4g/；
(8) it polishes, select：Remove the powder of capsule surface；Remove underproof product；
(9) packaging, quality inspection, storage.
4. a kind of preparation method of weight-reducing fat reducing capsule according to claim 3, it is characterised in that：In the step (1)
The clean area humiture is respectively 40 DEG C -45 DEG C, and 40%.
5. a kind of preparation method of weight-reducing fat reducing capsule according to claim 3, which is characterized in that in the step (2)
Microwave―assisted extraction steps are as follows：
(1) it is 80 mesh granularities to crush tealeaves, using aqueous solution as leaching agent, the mass ratio 1 of tealeaves and water:25；
(2) 10-15g Tea Samples are contained with 500mL triangular flasks and water is placed in micro-wave oven and carries out microwave digestion, microwave power tune
For 600W；
(3) Extracting temperature is 68 DEG C, 3 hours extraction times, obtains mixed solution；
(4) tea polyphenols are separated using ultra-filtration and separation, obtains tea polyphenols just extracting solution, condition is hollow-fibre membrane, and material is
Polysulfones, membrane aperture is between 0.0015-0.02 μm, membrane tube quantity 182, pipe range 26.3cm, single tube outer diameter 2.5mm, in single tube
Diameter 1.5mm, total membrane area 0.242m2, molecular cut off:30000D, operating pressure：0.08-0.14Mpa；Temperature≤60 DEG C.
6. a kind of preparation method of weight-reducing fat reducing capsule according to claim 3, which is characterized in that in the step (2)
Steps are as follows for low-temperature vacuum drying method：
(1) extracting solution at the beginning of tea polyphenols is put into vacuum freeze drier, is vacuumized；
(2) drying time is 12-24 hours, obtains tea polyphenols.
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| CN201810119350.8A CN108450951A (en) | 2018-02-06 | 2018-02-06 | A kind of weight-reducing fat reducing capsule and preparation method thereof |
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|---|---|---|---|
| CN201810119350.8A CN108450951A (en) | 2018-02-06 | 2018-02-06 | A kind of weight-reducing fat reducing capsule and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111419995A (en) * | 2020-04-24 | 2020-07-17 | 王宇 | Fat-reducing health-care traditional Chinese medicine formula |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101113147A (en) * | 2007-06-26 | 2008-01-30 | 朱江 | Method for tea by-product resource utilization |
| CN101618034A (en) * | 2009-07-19 | 2010-01-06 | 梁木鸿 | Capsule with effect of weight reducing and preparation technology thereof |
| CN105055670A (en) * | 2015-09-23 | 2015-11-18 | 威海紫光金奥力生物技术有限公司 | Green tea and carnitine capsule with function of reducing weight |
-
2018
- 2018-02-06 CN CN201810119350.8A patent/CN108450951A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101113147A (en) * | 2007-06-26 | 2008-01-30 | 朱江 | Method for tea by-product resource utilization |
| CN101618034A (en) * | 2009-07-19 | 2010-01-06 | 梁木鸿 | Capsule with effect of weight reducing and preparation technology thereof |
| CN105055670A (en) * | 2015-09-23 | 2015-11-18 | 威海紫光金奥力生物技术有限公司 | Green tea and carnitine capsule with function of reducing weight |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111419995A (en) * | 2020-04-24 | 2020-07-17 | 王宇 | Fat-reducing health-care traditional Chinese medicine formula |
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Application publication date: 20180828 |