CN105055579B - A kind of compound traditional Chinese medicine composite and preparation method for treating urolithiasis - Google Patents
A kind of compound traditional Chinese medicine composite and preparation method for treating urolithiasis Download PDFInfo
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- CN105055579B CN105055579B CN201510575573.1A CN201510575573A CN105055579B CN 105055579 B CN105055579 B CN 105055579B CN 201510575573 A CN201510575573 A CN 201510575573A CN 105055579 B CN105055579 B CN 105055579B
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Abstract
The present invention provides a kind of compound traditional Chinese medicine composite and preparation method for treating urolithiasis, it takes herba lysimachiae, endothelium corneum gigeriae galli, green plum, dianthus superbus, semen plantaginis, rust-coloured crotalaria herb with root to be uniformly mixed in proportion, 100 DEG C of decoctions of water is added to extract 3 times, extraction time is 1 ~ 3h, the quantity of solvent being added every time is 8 ~ 12(w/v of total medicinal material amount) times, 95% ethyl alcohol of 3 times of amounts is added in combined extract, concentration filtrate to the 5% ~ 15% of original volume, precipitating, supernatant is taken, after concentration, medicinal extract is spray-dried to obtain powder.It takes mole cricket to remove the end, the wing, pawl, sets in pot with mild fire baked coke, pulverization.Said extracted object powder is uniformly mixed.The present invention is pure Chinese medicinal preparation, combines a variety of herbaceous plant extracts with animal body Chinese medicine, and synergistic, Tonglin Paishi is clearing heat and detoxicating, is had no toxic side effect, significant effect.
Description
Technical field
The present invention provides a kind of compound traditional Chinese medicine composite for treating urolithiasis, while additionally providing preparation method, belongs to
Cure pharmaceutical technology field.
Background technique
The leaching of urolithiasis, also known as sand, sandstone leaching, are the common disease and frequently-occurring disease of Nephrology dept.'s clinic, with difficulty and pain in micturition, urinate sandstone out
Frequent micturition, urgent urination, urodynia and urine intention the bladders excitation symptom such as not to the utmost are prominent clinical manifestation.Mostly because of lower burnt accumulated heat, aqueous institute is decocted
It causes.Not only pain is hard to bear by patient, more it is poverty-stricken unbearably, seriously affected the normal life of patient.It treats in urolithiasis method, operation is controlled
It is relatively conventional to treat ultrasonic wave rubble, but it is not only expensive, it is easier to cause Stone obstruction since row's stone is not thorough.In
Medicine row's stone is not only cheap, significant effect, and uneasy to recur, is easy to people's receiving.
Summary of the invention
The present invention provides a kind of compound traditional Chinese medicine composite for treating urolithiasis, all medicines are synergistic, have clearing heat and detoxicating, sharp
Effect that water is treating stranguria, is easily absorbed by the human body, and has no toxic side effect, significant effect.
It is provided by the invention treatment urolithiasis compound traditional Chinese medicine composite, it is characterised in that be by following raw material by weight
It is manufactured: 10 ~ 15 parts of herba lysimachiae, 8 ~ 15 parts of endothelium corneum gigeriae galli, 1 ~ 10 part of green plum, 1 ~ 10 part of dianthus superbus, 1 ~ 10 part of semen plantaginis, rust-coloured crotalaria herb with root 1 ~
10 parts, 1 ~ 10 part of mole cricket.
The preparation process of the compound traditional Chinese medicine composite of the treatment urolithiasis, comprising the following steps:
It takes herba lysimachiae, endothelium corneum gigeriae galli, green plum, dianthus superbus, semen plantaginis, rust-coloured crotalaria herb with root to be uniformly mixed in proportion, 100 DEG C of decoctions of water is added to mention
Take 3 times, extraction time is 1 ~ 3h, and the quantity of solvent being added every time is 8 ~ 12(w/v of total medicinal material amount) times, combined extract, concentration
To the 5% ~ 15% of original volume 95% ethyl alcohol of 3 times of amounts is added, precipitating takes supernatant, after concentration, medicinal extract is spray-dried to obtain powder in filtrate
End.It takes mole cricket to remove the end, the wing, pawl, sets in pot with mild fire baked coke, pulverization.Said extracted object powder is uniformly mixed.
In pharmaceutical preparation of the present invention, herba lysimachiae has invigorating gallbladder and removing gall-stone and diuresis and stone expeling effect.In the alcohol-insoluble substances of herba lysimachiae
Polysaccharide component have inhibiting effect to the crystallization of the main component calcium oxalate monohydrate CaC2O4H2O of lithangiuria.And inhibit to make
With increasing with the increase of concentration.Herba lysimachiae can also make blood, urine slant acidity, make the calculus existing for ability in alkaline environment
Dissolution.Endothelium corneum gigeriae galli original name " Calusena lansium ", history is loaded in Shennong's Herbal, " master rushes down benefit ", stomach strengthening and digestion promoting, arresting seminal emission, treating stranguria fossil,
Clinic proves that endothelium corneum gigeriae galli is treating stranguria fossil is with raw preferably.Contain pepsin in studies have shown that endothelium corneum gigeriae galli, keratin like protein enzyme and
17 kinds of amino acid such as arginine glutamate, and endothelium corneum gigeriae galli has from a wealth of sources, convenient, economical and practical advantage of drawing materials.In green plum
Rich in citric acid, calcareous (calculus) in blood, kidney gallbladder is just easily dissolved once in conjunction with citric acid, becomes calcium citrate,
It is excreted by urine and bile duct, thus can achieve the effect of prevention and treatment kidney, gall stone.The citric acid content of green plum is up to
50% or more, therefore be most suitable for being used to prevent and treat calculus.Dianthus superbus has heat-clearing, diuresis, blood-breaking promoting menstruation effect.Semen plantaginis has aobvious
The diuresis of work, while can increase urea, chloride, the excretion of uric acid etc., for difficult urination caused by bladder heat stagnation,
Leaching drips the diseases such as puckery pain.Rust-coloured crotalaria herb with root can tonifying spleen kidney, diuresis, detumescence pain.Mole cricket is the full worm of drying of Gryllotalpidae insect mole cricket,
Grind powder can sharp stool and urine, lead to urolithiasis, eliminating dampness and heat.All medicines cooperate with compatibility, and Tonglin Paishi is clearing heat and detoxicating, and heat-clearing is cool
Blood, broken stasis of blood promoting the circulation of qi, warming meridians and promoting circulation of qi, play the function of simultaneous treatment of principal and subordinate symptoms invigorating gallbladder and removing gall-stone and diuresis and stone expeling altogether.
[usage and dosage] is oral twice daily, each 4-6g, most courses for the treatment of 1 month, and serious person 3 ~ 4 months.
[major function] Tonglin Paishi is clearing heat and detoxicating
Criterion of therapeutical effect: referring to the diagnosis basis of urolithiasis, card marquis classification, curative effect in " tcm internal medicine Illnesses Diagnoses criterion of therapeutical effect "
Evaluation.
Cure: sandstone discharge, symptom disappear, and x ray photograph calculus shade disappears.
Improve: symptom improves, and x ray photograph calculus reduces or position moves down.
Be not cured: symptom and x-ray check that calculus is unchanged.
500 many cases are cured with drug of the present invention, significant in efficacy, wherein that cures completely accounts for 81.6%, that cures substantially is accounted for
17.2%, total effective rate is up to 98.8%.
The positive effect of the present invention is: for pure Chinese medicinal preparation, by a variety of herbaceous plant extracts and animal body Chinese medicine
Combination, synergistic, Tonglin Paishi is clearing heat and detoxicating, has no toxic side effect, significant effect.
Specific embodiment:
Below with reference to embodiment, the present invention will be further explained.It should be understood that following embodiment is only used for solving
The present invention is released, rather than is limited the scope of the invention.
Embodiment 1
Weigh herba lysimachiae 100g, endothelium corneum gigeriae galli 80g, green plum 10g, dianthus superbus 10g, semen plantaginis 10g, rust-coloured crotalaria herb with root 10g, mole cricket 10g；
Herba lysimachiae, endothelium corneum gigeriae galli, green plum, dianthus superbus, semen plantaginis, rust-coloured crotalaria herb with root are mixed, adds 100 DEG C of decoctions of water of 6 times of weight to extract 3 times, mentions
Taking the time is 1 ~ 3h, and combined extract is concentrated filtrate to the 5% ~ 15% of original volume, 95% ethyl alcohol of 3 times of amounts is added, precipitating takes
Clearly, after concentration, medicinal extract is spray-dried to obtain powder.It takes mole cricket to remove the end, the wing, pawl, sets in pot with mild fire baked coke, pulverization.
Said extracted object powder is uniformly mixed to obtain the final product.
Embodiment 2
Weigh herba lysimachiae 120g, endothelium corneum gigeriae galli 100g, green plum 50g, dianthus superbus 50g, semen plantaginis 50g, rust-coloured crotalaria herb with root 50g, mole cricket
50g；Herba lysimachiae, endothelium corneum gigeriae galli, green plum, dianthus superbus, semen plantaginis, rust-coloured crotalaria herb with root are mixed, 100 DEG C of decoctions of water of 7 times of weight is added to extract 3
Secondary, extraction time is 1 ~ 3h, and combined extract, 95% ethyl alcohol of 3 times of amounts is added in concentration filtrate to the 5% ~ 15% of original volume, heavy
It forms sediment, takes supernatant, after concentration, medicinal extract is spray-dried to obtain powder.It takes mole cricket to remove the end, the wing, pawl, sets in pot with mild fire baked coke, grind
At smalls.Said extracted object powder is uniformly mixed to obtain the final product.
Embodiment 3
Weigh herba lysimachiae: 150g, endothelium corneum gigeriae galli 150g, green plum 100g, dianthus superbus 100g, semen plantaginis 100g, rust-coloured crotalaria herb with root 100g, mole cricket
Mqb 100g；Herba lysimachiae, endothelium corneum gigeriae galli, green plum, dianthus superbus, semen plantaginis, rust-coloured crotalaria herb with root are mixed, 100 DEG C of decoctions of water of 8 times of weight is added to extract
3 times, extraction time is 1 ~ 3h, and combined extract, 95% ethyl alcohol of 3 times of amounts is added in concentration filtrate to the 5% ~ 15% of original volume, heavy
It forms sediment, takes supernatant, after concentration, medicinal extract is spray-dried to obtain powder.It takes mole cricket to remove the end, the wing, pawl, sets in pot with mild fire baked coke, grind
At smalls.Said extracted object powder is uniformly mixed to obtain the final product.
Following experiments show compound extract of the present invention the utility model has the advantages that
1. experimental material
Wistar rat, regular grade, Beijing Vital River Experimental Animals Technology Co., Ltd. provide.
2. experimental method and result
Influence of the compound stranguria-treating and calculus-removing tablet to rat kidney stone: choosing 190~240 g ♂ rat 108 of weight, with
Machine is divided into 6 groups, every group 18.Daily stomach-filling 1 time, continuous 30 d.During this period, in addition to blank control group, remaining 5
Group feed added with 2% ethylene glycol, 1% ammonium chloride basal feed (in every 100 g feed be added 2 g of ethylene glycol.Ammonium chloride 1
G), and primary in intramuscular injection vitamine D3 weekly, 30,000 units/kg cause kidney stone model.It is put to death at the end of experiment dynamic
Object cuts open the belly and observes double kidney shapes, takes out double kidneys, longitudinally splits, with dissection sem observation kidney section whether there is or not obvious crystalline deposit object and
Free calculus or calcified plaque are as the standard for judging calculus.
The influence of 1 compound extract rat kidney stone of table
T is examined, X2It examines, compared with model control group, * P ﹤ 0. 05;P ﹤ 0. 01.Compared with blank control group,
△ △ P ﹤ 0. 01
The result shows that the kidney knot that each dosage group of Chinese traditional compound medicine of the present invention can obviously prevent ethylene glycol, ammonium chloride from inducing
Stone is formed, and makes the reduction of rat stone formation rate, and low dose group effect and positive control drug are close.And therapeutic effect is with agent
Amount increases and is significantly improved.
Part chosen below cures case to illustrate curative effect of the invention:
Case 1:
Zhao, male 35 years old, difficulty and pain in micturition frequency is anxious, and waist eilema takes 1 course for the treatment of of drug of the preparation of the embodiment of the present invention 1
Symptom disappears afterwards, without recurrence in 1 year.
Case 2:
Liu, male 58 years old, in September, 2013 starts hematuria symptom occur, and routine urianlysis has the frequent cold sweat of red blood cell, nausea
Vomiting, after taking 2 courses for the treatment of of drug prepared by the embodiment of the present invention 2, symptom disappears, without recurrence in 1 year.
Case 3:
Zhang, female, 45 years old, there was a tenderness in flank portion, and B ultrasound prompts the left multiple calculus of kidney, respectively 0.5mm × 0.4mm,
0.3mm × 0.4mm, 0.2mm × 0.4mm, after taking 2 courses for the treatment of of drug prepared by the embodiment of the present invention 3, calculus disappears, and 1 year
Interior no recurrence.
Case 4:
Mr. Yu, male 50 years old, stuttering urination is difficult, and urine flow is interrupted, blood urine, urine urgency-frequency, and has soreness of waist waist to rise, pubis connection
Dull pain is closed, urine has sandstone discharge, B ultrasound combination x-ray inspection diagnosis are as follows: left side ureter radiopaque calculus.It takes of the invention real
After 3 courses for the treatment of of drug for applying the preparation of example 1, symptom disappears, and x ray photograph calculus shade disappears, without recurrence in 1 year.
Claims (2)
1. a kind of compound traditional Chinese medicine composite for treating urolithiasis, it is characterised in that be following raw material by weight made of: gold
10 ~ 15 parts of money grass, 8 ~ 15 parts of endothelium corneum gigeriae galli, 1 ~ 10 part of green plum, 1 ~ 10 part of dianthus superbus, 1 ~ 10 part of semen plantaginis, 1 ~ 10 part of rust-coloured crotalaria herb with root, mole cricket
1 ~ 10 part.
2. the preparation process of the compound traditional Chinese medicine composite for the treatment of urolithiasis described in claim 1, comprising the following steps:
It takes herba lysimachiae, endothelium corneum gigeriae galli, green plum, dianthus superbus, semen plantaginis, rust-coloured crotalaria herb with root to be uniformly mixed in proportion, 100 DEG C of decoctions of water is added to extract 3
Secondary, extraction time is 1 ~ 3h, and the quantity of solvent being added every time is 8 ~ 12(w/v of total medicinal material amount) times, filtrate is concentrated in combined extract
To the 5% ~ 15% of original volume, 95% ethyl alcohol of 3 times of amounts is added, precipitating takes supernatant, after concentration, medicinal extract is spray-dried to obtain powder；
It takes mole cricket to remove the end, the wing, pawl, sets in pot with mild fire baked coke, pulverization；Said extracted object powder is uniformly mixed.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263460A (en) * | 2013-04-27 | 2013-08-28 | 潘首德 | New method for preparing compound stranguria-treating and calculus-removing tablets |
| CN103705773A (en) * | 2013-12-30 | 2014-04-09 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for achieving antibacterial and anti-inflammation effects and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263460A (en) * | 2013-04-27 | 2013-08-28 | 潘首德 | New method for preparing compound stranguria-treating and calculus-removing tablets |
| CN103705773A (en) * | 2013-12-30 | 2014-04-09 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for achieving antibacterial and anti-inflammation effects and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 排石茶治疗泌尿系结石临床疗效分析;何丽萍;《河北医学》;20070930;第13卷(第9期);第1176页左栏最后1段 * |
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