CN105055579A - Compound traditional Chinese medicine composition for treating urolithiasis and preparation method thereof - Google Patents
Compound traditional Chinese medicine composition for treating urolithiasis and preparation method thereof Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a compound traditional Chinese medicine composition for treating urolithiasis and a preparation method thereof. The method comprises the steps of: taking Lysimachia christinae Hance, endothelium corneum gigeriae galli, green plum, fringed pink, semen plantaginis and rust-coloured crotalaria herb with root for uniformly mixing, adding water, decocting at 100 DEG C and extracting for three times, wherein the extracting time is 1 to 3h and a solvent added every time is 8 to 12(w/v) times of a total medicinal material amount, combining the extracting solutions, concentrating filter liquor to 5 to 15% of the original volume, adding 95% ethyl alcohol of three times, precipitating, taking supernatant, and spray-misting an extract to obtain powder; taking mole crickets, completely removing heads, wings and claws, baking in a pot with slow fire, and grinding into powder. The extract powder is mixed uniformly. The compound traditional Chinese medicine composition is a pure traditional Chinese medicine preparation, extracts of various herbaceous plants and the animal Chinese medicinal material are mixed for synergistic interaction, treating stranguria, removing urinary calculus and clearing away heat and toxic materials, and are obvious in effect without toxic and side effects.
Description
Technical field
The invention provides a kind of compound traditional Chinese medicine composite for the treatment of stranguria caused by urinary stone, additionally provide its preparation method simultaneously, belong to traditional Chinese medical science pharmaceutical technology sectors.
Background technology
Stranguria caused by urinary stone, drenches also known as sand Stranguria, sandstone, be the clinical commonly encountered diseases of Urology Department and frequently-occurring disease, with difficulty and pain in micturition, urinate sandstone frequent micturition, urgent micturition, dysurea and urine meaning not to the utmost etc. bladder excitation symptom be outstanding clinical manifestation.Many because of part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels accumulated heat, decoct caused by water liquid.Patient not only pain is hard to bear, more unbearably poverty-stricken, has had a strong impact on the orthobiosis of patient.In treatment stranguria caused by urinary stone method, operative treatment ultrasound wave rubble is comparatively common, but it is not only expensive, does not easilier thoroughly cause Stone obstruction due to calculus.Adopt traditional Chinese medicine lithagogue not only cheap, Be very effective, and not easily recur, be easy to people and accept.
Summary of the invention
The invention provides a kind of compound traditional Chinese medicine composite for the treatment of stranguria caused by urinary stone, all medicine Synergistics, have effect of heat-clearing and toxic substances removing, relieving stranguria by diuresis, are easy to absorption of human body, have no side effect, Be very effective.
The compound traditional Chinese medicine composite for the treatment of stranguria caused by urinary stone provided by the invention, it is characterized in that being made up by weight of following raw material: Herba Lysimachiae 10 ~ 15 parts, Endothelium Corneum Gigeriae Galli 8 ~ 15 parts, 1 ~ 10 part, Armeniaca mume Sieb., Herba Dianthi 1 ~ 10 part, Semen Plantaginis 1 ~ 10 part, Herba Crotalariae Ferrugineae 1 ~ 10 part, Gryllotalpa 1 ~ 10 part.
The preparation technology of the compound traditional Chinese medicine composite of described treatment stranguria caused by urinary stone, comprises the following steps:
Get Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Armeniaca mume Sieb., Herba Dianthi, Semen Plantaginis, Herba Crotalariae Ferrugineae mix homogeneously in proportion, add water 100 DEG C and decoct extraction 3 times, extraction time is 1 ~ 3h, and the quantity of solvent at every turn added is 8 ~ 12(w/v of total medical material amount) doubly, merge extractive liquid, concentrated filtrate is to 5% ~ 15% of original volume, add 95% ethanol of 3 times amount, precipitation, gets supernatant, after concentrated, extractum spraying dry is obtained powder.Get Gryllotalpa and remove the end, the wing, pawl, put with slow fire baked coke in pot, pulverization.By said extracted thing powder mix homogeneously.
In pharmaceutical preparation of the present invention,
herba Lysimachiaethere are cholagogic and lithagogue and diuresis and expelling stone effect.The crystallization of polysaccharide component in the alcohol-insoluble substances of Herba Lysimachiae to the main component Calcium oxalate (CaC2O4) monohydrate CaC2O4H2O of lithangiuria has inhibitory action.And inhibitory action increases with the increase of concentration.Herba Lysimachiae also can make blood, urine slant acidity, makes the litholysis that could exist in alkaline environment.
endothelium Corneum Gigeriae Gallioriginal name " Clausena lansium (Lour.) Skeels ", history is loaded in Shennong's Herbal, " master rushes down profit ", invigorating the stomach and promoting digestion, arresting seminal emission, treating stranguria fossil, clinical proof, and Endothelium Corneum Gigeriae Galli is treating stranguria, and fossil is used as well with raw.Research display, containing pepsin in Endothelium Corneum Gigeriae Galli, 17 seed amino acids such as keratin like protein enzyme and arginine glutamate, and Endothelium Corneum Gigeriae Galli has wide material sources, draws materials conveniently, economical and practical advantage.
armeniaca mume Sieb.in be rich in citric acid, calcareous (calculus) in blood, kidney gallbladder once be combined with citric acid, be just easy to dissolve, become calcium citrate, excreted by urine and bile duct, so just can reach prevent and treat kidney, cholelithiasis effect.The citric acid content of Armeniaca mume Sieb. up to more than 50%, the therefore the most applicable prevention and therapy calculus that is used for.
herba Dianthithere is heat clearing away, diuresis, removing blood stasis stimulate the menstrual flow effect.
semen Plantaginisthere is significant diuresis, can carbamide be increased, chloride, the excretion of uric acid etc. simultaneously, for the dysuria caused by accumulation of heat in the urinary bladder, drench the diseases such as the puckery pain of drop.
herba Crotalariae Ferrugineaecan spleen reinforcing kidney, diuresis, detumescence pain.
gryllotalpa, be the dry Scorpio of Gryllotalpidae insecticide Gryllotalpa, it grinds powder can sharp defecation, logical stranguria caused by urinary stone, eliminating damp-heat.Described all medicines work in coordination with compatibility, Tonglin Paishi, heat-clearing and toxic substances removing, and clearing away heat and cooling blood, removing blood stasis with potent drugs circulation of qi promoting, warming the meridian and promoting blood circulation, play the merit for the treatment of both the principal and the secondary aspects of a disease at the same time cholagogic and lithagogue and diuresis and expelling stone altogether.
[usage and dosage] oral every day twice, each 4-6g, most 1 month course for the treatment of, severe patient 3 ~ 4 months.
[function cures mainly] Tonglin Paishi, heat-clearing and toxic substances removing
Criterion of therapeutical effect: the diagnosis basis of the middle stranguria caused by urinary stone of reference " tcm internal medicine Illnesses Diagnoses criterion of therapeutical effect ", card marquis classification, efficacy evaluation.
Cure: sandstone is discharged, transference cure, x-ray is taken the photograph sheet calculus shade and is disappeared.
Take a turn for the better: symptom is improved, x-ray is taken the photograph sheet calculus and to be reduced or position moves down.
Do not heal: symptom and x-ray check that calculus is unchanged.
Cured 500 many cases with medicine of the present invention, evident in efficacy, that wherein cures completely accounts for 81.6%, and that substantially cures accounts for 17.2%, and total effective rate reaches 98.8%.
good effect of the present invention is:for pure Chinese medicinal preparation, multiple herbaceous plant extract and animal body Chinese crude drug are combined, Synergistic, Tonglin Paishi, heat-clearing and toxic substances removing, has no side effect, Be very effective.
detailed description of the invention:
Below in conjunction with embodiment, the present invention is further explained.Should be understood that, following examples only for explaining the present invention, instead of limit the scope of the invention.
embodiment 1
Take Herba Lysimachiae 100g, Endothelium Corneum Gigeriae Galli 80g, Armeniaca mume Sieb. 10g, Herba Dianthi 10g, Semen Plantaginis 10g, Herba Crotalariae Ferrugineae 10g, Gryllotalpa 10g; By Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Armeniaca mume Sieb., Herba Dianthi, Semen Plantaginis, Herba Crotalariae Ferrugineae mixing, 100 DEG C, the water adding 6 times of weight decocts extraction 3 times, extraction time is 1 ~ 3h, merge extractive liquid, concentrated filtrate, to 5% ~ 15% of original volume, adds 95% ethanol of 3 times amount, precipitation, get supernatant, after concentrated, extractum spraying dry is obtained powder.Get Gryllotalpa and remove the end, the wing, pawl, put with slow fire baked coke in pot, pulverization.By said extracted thing powder mix homogeneously and get final product.
embodiment 2
Take Herba Lysimachiae 120g, Endothelium Corneum Gigeriae Galli 100g, Armeniaca mume Sieb. 50g, Herba Dianthi 50g, Semen Plantaginis 50g, Herba Crotalariae Ferrugineae 50g, Gryllotalpa 50g; By Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Armeniaca mume Sieb., Herba Dianthi, Semen Plantaginis, Herba Crotalariae Ferrugineae mixing, 100 DEG C, the water adding 7 times of weight decocts extraction 3 times, extraction time is 1 ~ 3h, merge extractive liquid, concentrated filtrate, to 5% ~ 15% of original volume, adds 95% ethanol of 3 times amount, precipitation, get supernatant, after concentrated, extractum spraying dry is obtained powder.Get Gryllotalpa and remove the end, the wing, pawl, put with slow fire baked coke in pot, pulverization.By said extracted thing powder mix homogeneously and get final product.
embodiment 3
Take Herba Lysimachiae: 150g, Endothelium Corneum Gigeriae Galli 150g, Armeniaca mume Sieb. 100g, Herba Dianthi 100g, Semen Plantaginis 100g, Herba Crotalariae Ferrugineae 100g, Gryllotalpa 100g; By Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Armeniaca mume Sieb., Herba Dianthi, Semen Plantaginis, Herba Crotalariae Ferrugineae mixing, 100 DEG C, the water adding 8 times of weight decocts extraction 3 times, extraction time is 1 ~ 3h, merge extractive liquid, concentrated filtrate, to 5% ~ 15% of original volume, adds 95% ethanol of 3 times amount, precipitation, get supernatant, after concentrated, extractum spraying dry is obtained powder.Get Gryllotalpa and remove the end, the wing, pawl, put with slow fire baked coke in pot, pulverization.By said extracted thing powder mix homogeneously and get final product.
following experiments indicates the beneficial effect of compound extract of the present invention:
1. experiment material
Wistar rat, regular grade, Beijing Vital River Experimental Animals Technology Co., Ltd. provides.
2. experimental technique and result
Compound urolithic stranguria unlock sheet is on the impact of kidney of rats calculus: choose body weight 190 ~ 240g ♂ rat 108, be divided into 6 groups at random, often organizes 18.Every day gavage 1 time, continuous 30d.During this period, except blank group, all the other 5 groups are fed and are added with 2% ethylene glycol, the normal feedstuff of 1% ammonium chloride (adds ethylene glycol 2g in every 100g feedstuff.Ammonium chloride 1g), and once, 30,000 units/kg, causes renal calculus model in intramuscular injection vitamin D3 weekly.Put to death animal at the end of experiment, cut open the belly and observe two kidney profile, take out two kidney, longitudinally cut open, observe kidney section with or without obvious crystalline deposit thing and free calculus or calcified plaque as the standard judging calculus with anatomical lens.
The impact of table 1 compound extract kidney of rats calculus
T checks, X
2inspection, compares with model control group, * P ﹤ 0.05; P ﹤ 0.01.Compare with blank group, △ △ P ﹤ 0.01
Result shows, each dosage group of Chinese traditional compound medicine of the present invention can obviously prevent ethylene glycol, ammonium chloride brings out renal calculus is formed, and rat stone formation rate is reduced, low dose group effect and positive control drug close.And therapeutic effect increases along with dosage and is significantly improved.
following selection portion divides healing case so that curative effect of the present invention to be described:
Case 1:
Zhao, man 35 years old, difficulty and pain in micturition is frequently anxious, waist angina abdominis, and transference cure after 1 course for the treatment of of medicine of taking prepared by the embodiment of the present invention 1, without recurrence in 1 year.
Case 2:
Liu, man 58 years old, in JIUYUE, 2013 starts to occur hematuria symptom, and routine urianlysis has the frequent cold sweat of erythrocyte, nausea and vomiting, and after taking 2 courses for the treatment of of medicine prepared by the embodiment of the present invention 2, transference cure, without recurrence in 1 year.
Case 3:
Zhang, female, 45 years old, there was tenderness in flank portion, and B ultrasonic points out left kidney multiple calculus, is respectively 0.5mmX0.4mm, 0.3mmX0.4mm, 0.2mmX0.4mm, and after taking 2 courses for the treatment of of medicine prepared by the embodiment of the present invention 3, calculus disappears, without recurrence in 1 year.
Case 4:
In certain, man 50 years old, stuttering urination difficulty, urine stream interrupts, hematuria, urine urgency-frequency, and has soreness of waist waist to rise, and dull pain on pubic symphysis, urine has sandstone to discharge, and B ultrasonic is diagnosed as in conjunction with x-ray inspection: left side ureter radiopaque calculus.After taking 3 courses for the treatment of of medicine prepared by the embodiment of the present invention 1, transference cure, x-ray is taken the photograph sheet calculus shade and is disappeared, without recurrence in 1 year.
Claims (2)
1. treat a compound traditional Chinese medicine composite for stranguria caused by urinary stone, it is characterized in that being made up by weight of following raw material: Herba Lysimachiae 10 ~ 15 parts, Endothelium Corneum Gigeriae Galli 8 ~ 15 parts, 1 ~ 10 part, Armeniaca mume Sieb., Herba Dianthi 1 ~ 10 part, Semen Plantaginis 1 ~ 10 part, Herba Crotalariae Ferrugineae 1 ~ 10 part, Gryllotalpa 1 ~ 10 part.
2. the preparation technology of the compound traditional Chinese medicine composite for the treatment of stranguria caused by urinary stone according to claim 1, comprises the following steps:
Get Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Armeniaca mume Sieb., Herba Dianthi, Semen Plantaginis, Herba Crotalariae Ferrugineae mix homogeneously in proportion, add water 100 DEG C and decoct extraction 3 times, extraction time is 1 ~ 3h, and the quantity of solvent at every turn added is 8 ~ 12(w/v of total medical material amount) doubly, merge extractive liquid, concentrated filtrate is to 5% ~ 15% of original volume, add 95% ethanol of 3 times amount, precipitation, gets supernatant, after concentrated, extractum spraying dry is obtained powder; Get Gryllotalpa and remove the end, the wing, pawl, put with slow fire baked coke in pot, pulverization; By said extracted thing powder mix homogeneously.
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| CN116549427A (en) * | 2023-05-26 | 2023-08-08 | 时珍本草生物科技(中山)有限公司 | New use of hydroxycitric acid for treating cholelithiasis and cholecystitis induced by cholelithiasis |
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| CN103263460A (en) * | 2013-04-27 | 2013-08-28 | 潘首德 | New method for preparing compound stranguria-treating and calculus-removing tablets |
| CN103705773A (en) * | 2013-12-30 | 2014-04-09 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for achieving antibacterial and anti-inflammation effects and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263460A (en) * | 2013-04-27 | 2013-08-28 | 潘首德 | New method for preparing compound stranguria-treating and calculus-removing tablets |
| CN103705773A (en) * | 2013-12-30 | 2014-04-09 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for achieving antibacterial and anti-inflammation effects and preparation method thereof |
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| 何丽萍: "排石茶治疗泌尿系结石临床疗效分析", 《河北医学》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116549427A (en) * | 2023-05-26 | 2023-08-08 | 时珍本草生物科技(中山)有限公司 | New use of hydroxycitric acid for treating cholelithiasis and cholecystitis induced by cholelithiasis |
| CN116549427B (en) * | 2023-05-26 | 2024-01-26 | 时珍本草生物科技(中山)有限公司 | Application of hydroxycitric acid lactone in preparation of medicine for treating gall-stone |
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