CN106853021A - Prevent and treat Chinese medicine composition of CKD and its preparation method and application - Google Patents
Prevent and treat Chinese medicine composition of CKD and its preparation method and application Download PDFInfo
- Publication number
- CN106853021A CN106853021A CN201710131292.6A CN201710131292A CN106853021A CN 106853021 A CN106853021 A CN 106853021A CN 201710131292 A CN201710131292 A CN 201710131292A CN 106853021 A CN106853021 A CN 106853021A
- Authority
- CN
- China
- Prior art keywords
- parts
- root
- medicine composition
- chinese medicine
- cassia tree
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 78
- 239000000203 mixture Substances 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 241000522254 Cassia Species 0.000 claims abstract description 51
- 240000004980 Rheum officinale Species 0.000 claims abstract description 49
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 49
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 49
- 235000005412 red sage Nutrition 0.000 claims abstract description 49
- 241000427159 Achyranthes Species 0.000 claims abstract description 36
- 239000009636 Huang Qi Substances 0.000 claims abstract description 35
- 244000197580 Poria cocos Species 0.000 claims abstract description 35
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 35
- 241000405414 Rehmannia Species 0.000 claims abstract description 34
- 239000008187 granular material Substances 0.000 claims abstract description 19
- 239000002775 capsule Substances 0.000 claims abstract description 16
- 239000003826 tablet Substances 0.000 claims abstract description 16
- 239000006187 pill Substances 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 238000009472 formulation Methods 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- 239000012467 final product Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 20
- 239000000284 extract Substances 0.000 claims description 19
- 239000000706 filtrate Substances 0.000 claims description 16
- 238000004821 distillation Methods 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 13
- 239000000341 volatile oil Substances 0.000 claims description 13
- 238000000605 extraction Methods 0.000 claims description 12
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 238000010992 reflux Methods 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 5
- 230000001070 adhesive effect Effects 0.000 claims description 5
- 239000003921 oil Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 208000020832 chronic kidney disease Diseases 0.000 abstract description 50
- 210000003734 kidney Anatomy 0.000 abstract description 19
- 239000008280 blood Substances 0.000 abstract description 17
- 210000004369 blood Anatomy 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 11
- 210000000952 spleen Anatomy 0.000 abstract description 11
- 208000022831 chronic renal failure syndrome Diseases 0.000 abstract description 10
- 230000007812 deficiency Effects 0.000 abstract description 6
- 208000037157 Azotemia Diseases 0.000 abstract description 5
- 210000002784 stomach Anatomy 0.000 abstract description 4
- 208000009852 uremia Diseases 0.000 abstract description 3
- 210000001835 viscera Anatomy 0.000 abstract description 3
- 238000005728 strengthening Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 16
- 238000011282 treatment Methods 0.000 description 16
- 229940079593 drug Drugs 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 10
- 238000005469 granulation Methods 0.000 description 8
- 230000003179 granulation Effects 0.000 description 8
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 229940109239 creatinine Drugs 0.000 description 5
- 230000001684 chronic effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- -1 α keto acid compound Chemical group 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 206010061481 Renal injury Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000012907 honey Nutrition 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 208000037806 kidney injury Diseases 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000011552 rat model Methods 0.000 description 3
- 239000003390 Chinese drug Substances 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241001251949 Xanthium sibiricum Species 0.000 description 2
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 230000000116 mitigating effect Effects 0.000 description 2
- 238000001543 one-way ANOVA Methods 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 206010001580 Albuminuria Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010055171 Hypertensive nephropathy Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037601 Pyelonephritis chronic Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 201000006368 chronic pyelonephritis Diseases 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 208000033679 diabetic kidney disease Diseases 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000024924 glomerular filtration Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000013059 nephrectomy Methods 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000015096 spirit Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of Chinese medicine composition for preventing and treating CKD and its preparation method and application.The active component of the Chinese medicine composition is prepared from by the raw material of following weight portion：20~40 parts of the Radix Astragali, 6~12 parts of rheum officinale, 10~20 parts of the red sage root, 12~24 parts of prepared rhizome of rehmannia, 3~7 parts of Chinese cassia tree, 6~12 parts of the root of bidentate achyranthes, 6~12 parts of Poria cocos.The effect of there is the Chinese medicine composition logical internal organs to let out turbid, strengthening spleen, tonifying kidney, nourishing qi and blood, stagnation resolvation dampness removing, for treating chronic renal failure, azotemia phase and uremia early stage, Chinese medical discrimination belong to deficiency of spleen and stomach, it is wet it is turbid in accumulate or deficiency of spleen and stomach, obstruction of collaterals by blood stasis are main person.Any formulation for being suitable for clinic, including granule, mixture, capsule, pill and tablet can be prepared into.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition and its system for preventing and treating CKD
Preparation Method and application.
Background technology
CKD (chronic kidney diseases, CKDs) is also known as chronic renal insufficiency or chronic kidney hypofunction
Exhaust, be the disease of a kind of high prevalence and harm.Determined according to the CKDs clinical practice guidelines that NKF formulates
Justice：(1), kidney injury (Renal Structure or dysfunction) >=3 months, declines, kidney with or without glomerular filtration rate(GFR (GFR)
Dirty pathological examination exception or kidney injury (blood, urine composition or imageological examination exception)；(2), GFR ＜ 60mlmin-1
73m-2 >=3 month, with or without kidney injury evidence.CKDs is caused by many reasons, and pathological change differs, with albuminuria, blood
Urine, oedema and hypertension are Clinical symptoms.According to estimates, there are about 500,000,000 CKDs patients in the whole world, accounts for the 6.5%~10% of total population,
CKDs develops into the middle and later periods, it is possible to develop into chronic kidney hypofunction, even uremia, so that serious harm patient's is strong
The expense of health, its medicine and nursing will all increase sharply, and turn into global public health event, by the extensive of medical field
Concern.
At present, the medicine of western medical treatment CKDs has hormone, immunodepressant, ACEI/ARB classes etc., although with certain
Curative effect, but still have considerable part patient's unsatisfactory curative effect, and it is long to there is the course for the treatment of, is easy to knock-on after drug withdrawal, the compliance of patient compared with
The side effects such as difference.
Traditional Chinese medicine thinks that CKDs is under the jurisdiction of the categories such as " obstruction and rejection ", " oedema ", " consumptive disease ".Pathological state is asthenia in origin and asthenia in superficiality, spleen
Kidney qi deficiency and the wet stasis of blood are mutually tied, and its " wet, the stasis of blood heresy through the whole courses of disease of CKDs in the middle of " this theory is had been obtained in industry
Common recognition.Modern study shows that traditional Chinese medicine controls disease Related Risk Factors to preventing and treating CKDs, delays the delay of disease to develop,
Complication rate is reduced, is improved the aspect such as patients ' life quality and is played the role of irreplaceable, developed a kind of with the traditional Chinese medical science
Medicine characteristic, the compound Chinese medicinal preparation that can effectively prevent and treat CKDs is undoubtedly very crucial.
The content of the invention
Based on this, the invention provides a kind of Chinese medicine composition for preventing and treating CKD.
Concrete technical scheme is as follows：
A kind of Chinese medicine composition for preventing and treating CKD, the active component of the Chinese medicine composition is by following weight portion
Raw material is prepared from：20~40 parts of the Radix Astragali, 6~12 parts of rheum officinale, 10~20 parts of the red sage root, 12~24 parts of prepared rhizome of rehmannia, 3~7 parts of Chinese cassia tree,
6~12 parts of the root of bidentate achyranthes, 6~12 parts of Poria cocos.
Wherein in some embodiments, the active component of the Chinese medicine composition is by the raw material preparation of following weight portion
Into：Radix Astragali 28-32 parts, rheum officinale 8-10 parts, red sage root 14-16 parts, prepared rhizome of rehmannia 18-22 parts, Chinese cassia tree 4-6 parts, root of bidentate achyranthes 9-11 parts, Poria cocos
9-11 parts.
Present invention also offers the preparation method of the Chinese medicine composition of above-mentioned preventing and treating CKD.
Concrete technical scheme is as follows：
A kind of preparation method of the Chinese medicine composition of above-mentioned preventing and treating CKD, comprises the following steps：
(1) being added water in Chinese cassia tree carries out distillation extraction, and the Chinese cassia tree dregs of a decoction and water-soluble after Cortex Cinnamomi volatile oil, distillation are collected respectively
Liquid；
(2) ethanol water refluxing extraction is used after mixing rheum officinale and the red sage root, is filtered, filtrate is concentrated, obtain thick paste A, and
Collect the rheum officinale and the red sage root dregs of a decoction after extracting；
(3) by the Chinese cassia tree dregs of a decoction described in step (1), the rheum officinale described in step (2) and the red sage root dregs of a decoction, the Radix Astragali, prepared rhizome of rehmannia, ox
Knee and Poria cocos merge, and add water to cook, and decocting liquid is merged with the aqueous solution described in step (1), filter, and filtrate is concentrated, and obtain thick paste
B；
(4) the thick paste B described in thick paste A described in combining step (2) and step (3), adds the Chinese cassia tree described in step (1) to wave
Hair oil, mixes, and obtains final product；Or the thick paste B described in the thick paste A described in step (2) and step (3) be dry, pulverize into dry extract
Powder, merges, and adds the Cortex Cinnamomi volatile oil described in step (1), mixes, and obtains final product.
Wherein in some embodiments, the volume fraction of ethanol water described in step (2) is 50~70%, described time
It is 1-2 times to flow the number of times for extracting, each 1-2 hours, the volume and the rheum officinale and red sage root gross weight of each ethanol water
The proportioning of amount is 6-12ml：1g.
Wherein in some embodiments, the number of times added water to cook described in step (3) is 2-3 times, each 1-2 hours, often
The consumption of secondary water is 8-12 times of medicinal material gross weight, and the medicinal material is the Chinese cassia tree, rheum officinale, the red sage root, the Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes
And Poria cocos.
A kind of preparation method of the Chinese medicine composition of above-mentioned preventing and treating CKD, comprises the following steps：
(1) rheum officinale, Chinese cassia tree are crushed, obtains the fine medicinal material powder of rheum officinale and Chinese cassia tree；
(2) Radix Astragali, the red sage root, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos are mixed, is added water to cook 2-3 times, it is each 1-2 hours, add every time
The amount for entering water is 8-12 times of medicinal material weight, and decocting liquid filtration, merging filtrate is concentrated to give thick paste, is vacuum dried, and is ground into dry extract
Powder；The medicinal material weight is the gross weight of the Radix Astragali, the red sage root, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos；
(3) fine medicinal material powder and dry extract are mixed, is obtained final product.
A kind of preparation method of the Chinese medicine composition of above-mentioned preventing and treating CKD, comprises the following steps：
(1) rheum officinale, the red sage root and Chinese cassia tree are crushed, obtains fine medicinal material powder；
(2) Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos are mixed, is added water to cook 2-3 times, it is each 1-2 hours, water is added every time
Amount be 8-12 times of medicinal material weight, decocting liquid is filtered, and merging filtrate is concentrated to give thick paste；The medicinal material weight is the Chinese cassia tree, ripe
The gross weight of glutinous rehmannia, the root of bidentate achyranthes and Poria cocos；
(3) with the thick paste as adhesive, the fine medicinal material powder is prepared into condensed pill, is obtained final product.
Present invention also offers the application of above-mentioned Chinese medicine composition.
Concrete technical scheme is as follows：
Application of the above-mentioned Chinese medicine composition in the medicine for preparing preventing and treating CKD.
Present invention also offers a kind of medicine for preventing and treating CKD.
Concrete technical scheme is as follows：
A kind of medicine for preventing and treating CKD, by acceptable auxiliary material preparation in above-mentioned Chinese medicine composition and medicine
Into.
Wherein in some embodiments, the formulation of the medicine includes granule, tablet, pill, capsule, mixture.
Above-mentioned granule, tablet, capsule, mixture can be prepared by the following method and obtain：Institute is prepared according to the above method
Chinese medicine composition is stated, the applicable auxiliary material of granule is added in the thick paste A and thick paste B of the merging, granulation is dried, added
The Cortex Cinnamomi volatile oil, obtains final product the granule；Or by the thick paste A and thick paste B of the merging, dry, pulverize, add piece
The applicable auxiliary material of agent, granulation is dried, and adds the Cortex Cinnamomi volatile oil, compressing tablet, or is coated, and obtains final product the tablet；Or will be described
The thick paste A and thick paste B of merging, dry, pulverize, the auxiliary material for adding capsule applicable, mix, or granulation, add the Chinese cassia tree
Volatile oil, loads Capsules, obtains final product the capsule；Or add what mixture was applicable in the thick paste A and thick paste B of the merging
Preservative, or flavouring and corrective incense agent are added, the Cortex Cinnamomi volatile oil is added, ormal weight is added water to, filter, obtain final product the conjunction
Agent.
Above-mentioned granule, tablet, capsule can also be prepared by the following method and obtain：According to the above method prepare it is described in
Drug composition, the fine medicinal material powder and the dry extract is merged, the auxiliary material for adding granule applicable, and granulation is dried, and is obtained final product
The granule；Or merge the fine medicinal material powder and the dry extract, the auxiliary material for adding tablet applicable, granulation is dried, plus
Enter the applicable lubricant of tablet, compressing tablet, or be coated, obtain final product the tablet；Or close the fine medicinal material powder and the dry extract
And, the auxiliary material for adding capsule applicable, or granulation, dry, load Capsules, obtain final product the capsule.
Above-mentioned pill can be prepared by the following method and obtain：The dense of Chinese medicine composition is directly prepared according to the above method
Contracting ball；Or by rheum officinale, Chinese cassia tree, the Radix Astragali, prepared rhizome of rehmannia, the red sage root, the root of bidentate achyranthes, Poria cocos is ground into fine medicinal material powder, with refined honey as adhesive,
It is mixed and made into honeyed bolus.
Chinese medicine composition of preventing and treating CKD of the present invention and its preparation method and application has advantages below
And beneficial effect：
The present inventor had found with the Radix Astragali by lot of experiments, rheum officinale, the red sage root, prepared rhizome of rehmannia, Chinese cassia tree, the root of bidentate achyranthes and
Poria cocos has functions that significantly to prevent and treat CKD by preparation-obtained Chinese medicine composition after special ratios compatibility.Side
The middle Radix Astragali replenish qi to invigorate the spleen rising Yang fortune pivot, this void declined for spleen kidney deficiency and set, for treatment principal contradiction be monarch drug in a prescription；Rheum officinale can rush down
Can mend, rush down middle residence and mend, with clearing heat and detoxicating, logical internal organs is dispelled turbid, wet turbid heresy is discharged from stool, be i.e. the meaning of " the moon turbid go out lower orifices ", and
Work(with dredging collateral promoting blood circulation and removing blood stasis, is generally the mark reality interpretation of the cause, onset and process of an illness that accumulates in the wet turbid malicious stasis of blood and sets for CKD, and cultivated land is enriched blood benefit
Essence, the auxiliary Radix Astragali is ministerial drug to reach qi-blood tonifying purpose, altogether；Assistant is promoting blood circulation and removing obstruction in channels with red sage root nourishing and enriching blood；In the strong kidney of Chinese cassia tree
Sun, with the method for the treatment of YANG within YIN, reached the purpose of warming and invigorating kidney Yang；Root of bidentate achyranthes kidney tonifying, diuresis is ensuringd proper downward flow of the blood；Poria cocos promoting urination and removing dampness,
Invigorating the spleen.All medicines share, the effect of full side plays strengthening spleen, tonifying kidney, nourishing qi and blood, logical internal organs and lets out turbid, stagnation resolvation dampness removing altogether.For chronic kidney
The sick insufficiency of both the spleen and the kindey is this, and turbid malicious stasis blocking is the target interpretation of the cause, onset and process of an illness, can be used for chronic renal failure, azotemia phase and uremia morning
Phase, Chinese medical discrimination belong to deficiency of spleen and stomach, it is wet it is turbid in accumulate or deficiency of spleen and stomach, obstruction of collaterals by blood stasis be main person.
Chinese medicine composition of the invention has the advantages that determined curative effect, Small side effects.Use Chinese medicine group of the present invention
Compound is prepared into the preparations such as granule and is taken orally, it turned out that, the obvious effective rate of CKD is treated for 20%, effective percentage is
45%th, total effective rate is 65%, is significantly better than conventional western medicine treatment group (P<0.01), it is preventing and treating chronic renal failure (CRF)
A kind of effective preparation, it while delaying CRF to be in progress, also improve patients ' life quality effect.And by pharmacology reality
Checking is bright, and the granule that Chinese medicine composition of the present invention is prepared from can reduce by 5/6 nephrectomy method and prepare rat chronic kidney
The blood urea nitrogen (BUN) and creatinine (Cr) content of exhaustion model.
Chinese medicine composition of the present invention can also be prepared into decoction oral, but there is awkward shortcoming, therefore, will
It is made solid pharmaceutical preparation (including granule, pill, tablet, capsule or mixture) can overcome the shortcoming, increase patient medication
Adaptability.
Specific embodiment
Below in conjunction with specific embodiment to Chinese medicine composition and preparation method thereof of preventing and treating CKD of the invention and
Using doing further detailed description.
Embodiment 1
The present embodiment provides a kind of Chinese medicine composition (herb mixture) for preventing and treating CKD, and its active component is by following
The raw material of weight portion is prepared from：30 parts of the Radix Astragali, 9 parts of rheum officinale, 15 parts of the red sage root, 20 parts of prepared rhizome of rehmannia, 5 parts of Chinese cassia tree, 10 parts of the root of bidentate achyranthes, Fu
10 parts of Siberian cocklebur.
The preparation method of the herb mixture is as follows：
Being added water in Chinese cassia tree carries out distillation extraction, after the Chinese cassia tree dregs of a decoction and distillation after Cortex Cinnamomi volatile oil, distillation are collected respectively
The aqueous solution；
With the ethanol water refluxing extraction that volume fraction is 50% 1 hour after rheum officinale and the red sage root are mixed, ethanol is water-soluble
The consumption (volume) of liquid is 10ml with the proportioning of rheum officinale and red sage root gross weight：1g, filtration, filtrate recycling ethanol is simultaneously concentrated, and obtains thick
Cream A, and rheum officinale and the red sage root dregs of a decoction after extracting are collected, it is standby；
The above-mentioned Chinese cassia tree dregs of a decoction, rheum officinale and the red sage root dregs of a decoction are merged with the Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes, Poria cocos, two are added water to cook
It is secondary, 2 hours every time, every time add water amount for quality of medicinal material (Chinese cassia tree, rheum officinale, the red sage root, the Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos
Gross weight) 12 times, decocting liquid is merged with the aqueous solution after distillation, filtration, filtrate is concentrated to give thick paste B, standby；
The thick paste (thick paste B) that the thick paste (thick paste A) and water that above-mentioned ethanol is extracted are extracted merges, and adds water to ormal weight, plus
Enter the applicable auxiliary material of mixture, boil, refrigerate, filtration adds Cortex Cinnamomi volatile oil, mixes, filling, obtains final product.
Embodiment 2
The present embodiment provide it is a kind of prevent and treat CKD Chinese medicine composition (Chinese herbal granules), its active component by with
The raw material of lower weight portion is prepared from：30 parts of the Radix Astragali, 9 parts of rheum officinale, 15 parts of the red sage root, 20 parts of prepared rhizome of rehmannia, 5 parts of Chinese cassia tree, 10 parts of the root of bidentate achyranthes,
10 parts of Poria cocos
The preparation method of the Chinese herbal granules is as follows：
Being added water in Chinese cassia tree carries out distillation extraction, the Chinese cassia tree dregs of a decoction after Cortex Cinnamomi volatile oil, distillation is collected respectively and will be distilled
The aqueous solution afterwards；
It is secondary with the ethanol water refluxing extraction that volume fraction is 70% after rheum officinale and the red sage root are mixed, 1 hour every time,
The consumption (volume) of each ethanol water is 6ml with the proportioning of rheum officinale and red sage root gross weight：1g, filtration, filtrate is merged, and is returned
Receive ethanol and be concentrated to give thick paste, be vacuum dried, be ground into dry extract A, and collect the rheum officinale and the red sage root dregs of a decoction after extracting, it is standby
With；
The above-mentioned Chinese cassia tree dregs of a decoction, rheum officinale and the red sage root dregs of a decoction are merged with the Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes, Poria cocos, three are added water to cook
It is secondary, 1 hour every time, every time add water amount for quality of medicinal material (Chinese cassia tree, rheum officinale, the red sage root, the Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos
Gross weight) 8 times, take decocting liquid with distillation after the aqueous solution merges, filter, filtrate concentration, obtain thick paste, vacuum drying, be ground into
Dry extract B, it is standby；
Above-mentioned dry extract A and dry extract B is merged, the auxiliary material for adding granule applicable, granulation, add Chinese cassia tree volatilization
Oil, is mixed, and packing is obtained final product.
Embodiment 3
The present embodiment provides a kind of Chinese medicine composition (Chinese medicinal tablet) for preventing and treating CKD, and its active component is by following
The raw material of weight portion is prepared from：20 parts of the Radix Astragali, 6 parts of rheum officinale, 10 parts of the red sage root, 12 parts of prepared rhizome of rehmannia, 3 parts of Chinese cassia tree, 6 parts of the root of bidentate achyranthes, Fu
6 parts of Siberian cocklebur.
The preparation method of the Chinese medicinal tablet is as follows：
Rheum officinale, Chinese cassia tree are crushed, the fine medicinal material powder of rheum officinale and Chinese cassia tree is obtained, it is standby；
The Radix Astragali, the red sage root, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos are mixed, adds water to cook secondary, every time 1 hour, water is added every time
It is 12 times of quality of medicinal material (gross weight of the Radix Astragali, the red sage root, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos) to measure, decocting liquid filtration, and filtrate merges, dense
Contract to obtain thick paste, and thick paste dry, pulverize into dry extract, standby；
Above-mentioned fine medicinal material powder and dry extract are mixed, plus the applicable auxiliary material of tablet, granulation, compressing tablet, or be coated, obtain final product.
Embodiment 4
The present embodiment provide it is a kind of prevent and treat CKD Chinese medicine composition (Chinese medicine capsules), its active component by with
The raw material of lower weight portion is prepared from：20 parts of the Radix Astragali, 6 parts of rheum officinale, 10 parts of the red sage root, 12 parts of prepared rhizome of rehmannia, 3 parts of Chinese cassia tree, 6 parts of the root of bidentate achyranthes,
6 parts of Poria cocos.
The preparation method of the Chinese medicine capsules is as follows：
Being added water in Chinese cassia tree carries out distillation extraction, after the Chinese cassia tree dregs of a decoction and distillation after Cortex Cinnamomi volatile oil, distillation are collected respectively
The aqueous solution；
With the ethanol water refluxing extraction that volume fraction is 70% 1 hour after rheum officinale and the red sage root are mixed, ethanol is water-soluble
The consumption (volume) of liquid is 12ml with the proportioning of rheum officinale and red sage root gross weight：1g, filtration, filtrate recycling ethanol is simultaneously concentrated, and obtains thick
Cream, thick paste dry, pulverize into dry extract A, and collect the rheum officinale and the red sage root dregs of a decoction after extracting, standby；
The Chinese cassia tree dregs of a decoction, rheum officinale and the red sage root dregs of a decoction are merged with the Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes, Poria cocos, add water to cook it is secondary, often
Secondary 2 hours, the amount that water is added every time was the quality of medicinal material (gross weight of Chinese cassia tree, rheum officinale, the red sage root, the Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos
Amount) 8 times, filtration, by after filtrate and above-mentioned distillation the aqueous solution merge, be concentrated to give thick paste, be vacuum dried, be ground into dry extract
Powder B, it is standby；
Above-mentioned dry extract A and dry extract B is merged, the auxiliary material and Cortex Cinnamomi volatile oil for adding capsule applicable are mixed,
Load Capsules, obtain final product.
Embodiment 5
The present embodiment provide it is a kind of prevent and treat CKD Chinese medicine composition (traditional Chinese drug inspissation pill), its active component by
The raw material of following weight portion is prepared from：40 parts of the Radix Astragali, 12 parts of rheum officinale, 20 parts of the red sage root, 24 parts of prepared rhizome of rehmannia, 7 parts of Chinese cassia tree, the root of bidentate achyranthes 12
Part, 12 parts of Poria cocos.
The preparation method of the traditional Chinese drug inspissation pill is as follows：
Rheum officinale, the red sage root, Chinese cassia tree are crushed, fine medicinal material powder is obtained, it is standby；
The Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos are mixed, three times are added water to cook, 1 hour every time, the amount that water is added every time was
8 times of quality of medicinal material (gross weight of Chinese cassia tree, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos), decocting liquid filtration, filtrate merges, and is concentrated to give thick paste, standby
With；
With thick paste as adhesive, above-mentioned fine medicinal material powder is made condensed pill, dried, polishing is obtained final product.
Embodiment 6
The present embodiment provides a kind of Chinese medicine composition (traditional Chinese medicine pill) for preventing and treating CKD, and its active component is by following
The raw material of weight portion is prepared from：40 parts of the Radix Astragali, 12 parts of rheum officinale, 20 parts of the red sage root, 24 parts of prepared rhizome of rehmannia, 7 parts of Chinese cassia tree, 12 parts of the root of bidentate achyranthes,
12 parts of Poria cocos.
The preparation method of the traditional Chinese medicine pill is as follows：
Rheum officinale, Chinese cassia tree, the Radix Astragali, prepared rhizome of rehmannia, the red sage root, the root of bidentate achyranthes, Poria cocos are ground into fine medicinal material powder, with refined honey as adhesive,
Small honey pill is made, is dried, polishing is obtained final product.
Embodiment 7
The influence of Chinese herbal granules prepared by embodiment 2 to CKDs rat model BUN values and Cr values
(1) modeling operation
Take SD rats elder generation adaptability feed 7d, be randomly divided into Normal group, model control group, α keto acid compound group,
Clearing preparation-Niaoduqing group, Chinese herbal granules (hereinafter referred to as sample) high dose group of embodiment 2, sample middle dose group, sample low dosage
Group, every group 10.With 10% chloraldurate intraperitoneal injection of anesthesia animal, routine disinfection drape, from right midline incision, opens abdomen
Chamber.Venous clamp cuts off pole (excision 2/3) up and down of right kidney after clamping the kidney base of a fruit with electric knife, and reset kidney after hemostasis.Carried out after 2 weeks
2nd operation, cuts off left kidney.Normal group takes same step to open abdominal cavity, is resetted after exposure kidney, it is to avoid drawing
Kidney.Postoperative continuation letting animals feed, period close observation and situations such as record body weight, hair, the state of mind of rat.
(2) dosage is set and medication
α keto acid compound：Package insert sign α keto acid compound is oral, daily 7.56g.With clinical 7.56g days use
Based on amount, reference《Herbal pharmacology research methodology》Middle dosage conversion method determines pharmacodynamic experiment dosage, is 0.68g
kg-1.As method can obtain clearing preparation-Niaoduqing group for 2.25g particles kg-1, sample high dose group is 8.91g crude drugs kg-1, sample middle dosage
Group is 5.94g crude drugs kg-1, sample low dose group is 2.97g crude drugs kg-1.According to dosage prepared respectively with distilled water during experiment
Into required concentration.Modeling starts administration after 4 months, administered volume is 10mLkg-1, successive administration 12 weeks.
(3) assay method
Experiment terminates same day collection blood, serum is separated, with kit measurement Cr, BUN value.
(4) measurement result
Using SPSS22.0 softwares, all measurement datas add and subtract standard deviation with meanRepresent.Multigroup mean
Compare and use mean between one-way analysis of variance (One-WayANOVA), group to compare two-by-two, SNK methods are used when variance is neat；Variance
Dunnett ' s T3 methods are used when uneven.The results are shown in Table 1.
Table 1 to CKDs rat model BUN, Cr values influence (N=10)
Note：Compare with normal group, (1) P ＜ 0.05；Compare with model group, (2) P ＜ 0.05；
Through analysis, BUN values variance is without significant difference (Levene Statistic=1.739, P=0.127 ＞ 0.05), side
Difference is neat, and population mean comparing is carried out using F inspections, checks each horizontal average to compare two-by-two with SNK, the results are shown in Table 1.With normal group
Compare, model group has significant difference (P ＜ 0.05), point out modeling success；Compare with model control group, α keto acid compound
Group, clearing preparation-Niaoduqing group, sample high dose group, sample middle dose group and sample low dose group have significant difference (P ＜ 0.05), carry
Show that five groups of medicines have substantially for the Cr values and BUN values in the CKDs rat model serum prepared by 5/6 kidney surgery of reduction
Effect.
Embodiment 8
The therapeutic action of Chinese herbal granules prepared by embodiment 2 to chronic renal failure (CRF)
(1) physical data
Observation case totally 40, is Guangdong Province's second traditional Chinese medical science Out-patient Department and inpatient.It is wherein male 24, female 16.
25-75 years old ages, average 45 years old.Wherein, chronic nephritis 20, chronic pyelonephritis 6, hypertensive nephropathy, diabetic nephropathy
Each 5, UN 4.The course of disease of all CRF patients is (25.2 ± 10.8) individual month, and serum creatinine (Scr) level is
178-442 μm of ol/L, average out to (256.50 ± 158.25) μm ol/L.Patient symptom mainly has：A, Die Gastrointestinale Manifestation：
Such as apocleisis, abdominal discomfort；B, spirit, Manifestations of nervous system：One's spirits are drooping, tired, dizzy, headache, failure of memory, mistake
Sleep, can there is numb four limbs, brothers' cusalgia and skin gargalesthesia, or even lower limb itch pain unbearably, must often move, can not stop；c、
Other：Such as blood pressure rising, ecchymosis, nosebleed epistaxis, bleeding gums, oedema, become thin, symptom is more complicated in a word, patient main suit
Symptom differs.
(2) treatment method
All cases are randomly divided into two groups, treatment group and each 20 of control group, and two groups of physical data are poor through statistical test
It is different without conspicuousness, with comparativity.
Treatment group：The Chinese herbal granules prepared by the embodiment of the present invention 2 are taken, 3 times a day, the course for the treatment of 2 months.
Control group：Conventional western medicine is treated, the course for the treatment of 2 months.Conventional western medicine treatment is symptomatic treatment, such as it is anti-infective, be depressured, entangle
Positive Water-Electrolyte acid-base disturbance and dietetic treatment (the low albumen high heat food of high-quality, supplement essential amino acid) etc..
Two groups similar, does not carry out other treatments during medication.
(3) curative effect determinate standard：
It is effective：A, symptom mitigation or disappearance；B, endogenous creatinine clearance rate (Ccr) increase by 3 >=0%；C, serum creatinine (Scr) drop
Low >=30%.Above a is indispensability, and b, c possess one, you can judged.
Effectively：A, symptom mitigation or disappearance；B, Ccr increase >=20%；C, Scr reduction >=20%；With blood before and after d, treatment
The logarithm or inverse of creatinine, are analyzed with linear regression equation, and its slope has clear meaning.Above a is indispensability, and other possess one
, you can judge.
It is invalid：Effective and effective decision condition person is not met.
(4) statistical method
Using t inspections and χ2Inspection.
(5) treatment results
It is shown in Table 2 and table 3.Result shows that Chinese medicine composition of the invention can effectively prevent and treat chronic renal disease, is preventing and treating CRF
A kind of effective formula and drug, it while delaying CRF to be in progress, also improve patients ' life quality effect.
2 two groups of comparitive studies of table
Two groups are compared * P<0.01
About the change of laboratory indexes before and after 3 two groups of treatments of table
Note：Hb is hemoglobin, and Alb is albumin, and BUN is urea nitrogen；Compare * P before and after being treated with group<0.05, * * P<
0.01, △ P>0.05
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
Apply all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, the scope of this specification record is all considered to be.
Embodiment described above only expresses several embodiments of the invention, and its description is more specific and detailed, but simultaneously
Can not therefore be construed as limiting the scope of the patent.It should be pointed out that coming for one of ordinary skill in the art
Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. it is a kind of prevent and treat CKD Chinese medicine composition, it is characterised in that the active component of the Chinese medicine composition by with
The raw material of lower weight portion is prepared from：20~40 parts of the Radix Astragali, 6~12 parts of rheum officinale, 10~20 parts of the red sage root, 12~24 parts of prepared rhizome of rehmannia,
3~7 parts of Chinese cassia tree, 6~12 parts of the root of bidentate achyranthes, 6~12 parts of Poria cocos.
2. it is according to claim 1 preventing and treating CKD Chinese medicine composition, it is characterised in that the Chinese medicine composition
Active component be prepared from by the raw material of following weight portion：Radix Astragali 28-32 parts, rheum officinale 8-10 parts, red sage root 14-16 parts, cultivated land
It is yellow 18-22 parts, Chinese cassia tree 4-6 parts, root of bidentate achyranthes 9-11 parts, Poria cocos 9-11 parts.
3. described in a kind of claim 1 or 2 preventing and treating CKD Chinese medicine composition preparation method, it is characterised in that
Comprise the following steps：
(1) being added water in Chinese cassia tree carries out distillation extraction, and the Chinese cassia tree dregs of a decoction and the aqueous solution after Cortex Cinnamomi volatile oil, distillation are collected respectively；
(2) ethanol water refluxing extraction is used after mixing rheum officinale and the red sage root, is filtered, filtrate is concentrated, obtain thick paste A, and collect
Rheum officinale and the red sage root dregs of a decoction after extraction；
(3) the Chinese cassia tree dregs of a decoction, the rheum officinale and the red sage root dregs of a decoction, the Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos are merged, are added water to cook,
Decocting liquid is merged with the aqueous solution described in step (1), is filtered, filtrate is concentrated, obtain thick paste B；
(4) the thick paste B described in thick paste A described in combining step (2) and step (3), adds the Chinese cassia tree volatilization described in step (1)
Oil, mixes, and obtains final product；Or the thick paste B described in the thick paste A described in step (2) and step (3) be dry, pulverize into dry extract,
Merge, add the Cortex Cinnamomi volatile oil described in step (1), mix, obtain final product.
4. it is according to claim 3 preventing and treating CKD Chinese medicine composition preparation method, it is characterised in that step
(2) volume fraction of ethanol water described in is 50~70%, and the number of times of the refluxing extraction is 1-2 times, and each 1-2 is small
When, the volume of each ethanol water is 6-12ml with the proportioning of the rheum officinale and red sage root gross weight：1g.
5. it is according to claim 3 preventing and treating CKD Chinese medicine composition preparation method, it is characterised in that step
(3) number of times added water to cook described in is 2-3 times, each 1-2 hours, and the consumption of each water is 8-12 times of medicinal material gross weight,
The medicinal material is the Chinese cassia tree, rheum officinale, the red sage root, the Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos.
6. described in a kind of claim 1 or 2 preventing and treating CKD Chinese medicine composition preparation method, it is characterised in that
Comprise the following steps：
(1) rheum officinale, Chinese cassia tree are crushed, obtains the fine medicinal material powder of rheum officinale and Chinese cassia tree；
(2) Radix Astragali, the red sage root, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos are mixed, is added water to cook 1-3 times, it is each 1-3 hours, water is added every time
Amount be 8-12 times of medicinal material weight, decocting liquid is filtered, and merging filtrate is concentrated to give thick paste, dry, pulverize into dry extract；It is described
Medicinal material weight is the gross weight of the Radix Astragali, the red sage root, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos；
(3) fine medicinal material powder and dry extract are mixed, is obtained final product.
7. described in a kind of claim 1 or 2 preventing and treating CKD Chinese medicine composition preparation method, it is characterised in that
Comprise the following steps：
(1) rheum officinale, the red sage root and Chinese cassia tree are crushed, obtains fine medicinal material powder；
(2) Radix Astragali, prepared rhizome of rehmannia, the root of bidentate achyranthes and Poria cocos are mixed, is added water to cook 2-3 times, it is each 1-2 hours, the amount of water is added every time
It it is 8-12 times of medicinal material weight, decocting liquid filtration, merging filtrate is concentrated to give thick paste；The medicinal material weight is the Chinese cassia tree, cultivated land
The gross weight of the yellow, root of bidentate achyranthes and Poria cocos；
(3) with the thick paste as adhesive, the fine medicinal material powder is prepared into condensed pill, is obtained final product.
8. application of the Chinese medicine composition described in claim 1 or 2 in the medicine for preparing preventing and treating CKD.
9. it is a kind of prevent and treat CKD medicine, it is characterised in that Chinese medicine composition and medicine as described in claim 1 or 2
Acceptable auxiliary material is prepared from thing.
10. it is according to claim 9 preventing and treating CKD medicine, it is characterised in that the formulation of the medicine includes
Granule, tablet, pill, capsule, mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710131292.6A CN106853021A (en) | 2017-03-07 | 2017-03-07 | Prevent and treat Chinese medicine composition of CKD and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710131292.6A CN106853021A (en) | 2017-03-07 | 2017-03-07 | Prevent and treat Chinese medicine composition of CKD and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106853021A true CN106853021A (en) | 2017-06-16 |
Family
ID=59125322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710131292.6A Pending CN106853021A (en) | 2017-03-07 | 2017-03-07 | Prevent and treat Chinese medicine composition of CKD and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106853021A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114796348A (en) * | 2022-05-09 | 2022-07-29 | 山东第一医科大学附属省立医院(山东省立医院) | Kidney-tonifying and blood-activating paste and preparation method and application thereof |
| CN114848725A (en) * | 2022-06-28 | 2022-08-05 | 成都中医药大学附属医院 | Pharmaceutical composition for treating renal interstitial fibrosis and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188407A (en) * | 2011-05-16 | 2011-09-21 | 武汉大学 | Method for preparing compound Chinese medicine microcapsules |
-
2017
- 2017-03-07 CN CN201710131292.6A patent/CN106853021A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188407A (en) * | 2011-05-16 | 2011-09-21 | 武汉大学 | Method for preparing compound Chinese medicine microcapsules |
Non-Patent Citations (1)
| Title |
|---|
| 石丽霞等: "肾衰康口服液质量标准研究", 《特产研究》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114796348A (en) * | 2022-05-09 | 2022-07-29 | 山东第一医科大学附属省立医院(山东省立医院) | Kidney-tonifying and blood-activating paste and preparation method and application thereof |
| CN114796348B (en) * | 2022-05-09 | 2023-02-10 | 山东第一医科大学附属省立医院(山东省立医院) | Kidney-tonifying and blood-circulation-promoting paste for treating chronic renal failure and preparation method and application thereof |
| CN114848725A (en) * | 2022-06-28 | 2022-08-05 | 成都中医药大学附属医院 | Pharmaceutical composition for treating renal interstitial fibrosis and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102671137B (en) | Medicine composition for treating diabetic nephropathy and preparation method of medicine composition | |
| US20180369308A1 (en) | Chinese herbal medicine composition having a function of relieving hypothyroidism, preparation method and use thereof | |
| CN113616688B (en) | Anserine composition for repairing kidney injury and application thereof | |
| KR20160067553A (en) | A composition comprising medical herbs for improving respiratory diseases | |
| CN103721075B (en) | A kind of Chinese medicine for post gynecologic operation and preparation method thereof | |
| CN108853433A (en) | A kind of Chinese medicine and preparation method thereof for treating diabetic nephropathy | |
| CN106853021A (en) | Prevent and treat Chinese medicine composition of CKD and its preparation method and application | |
| CN103341092B (en) | Preparation method of powder for treating atrophic vaginitis | |
| CN102657736B (en) | Medicament composition for treating rheumatoid arthritis and preparation method of medicament composition | |
| CN106237263B (en) | A kind of acute icteric hepatitis and the chronic hepatitis acute onset for the treatment of is with the raised Chinese medicine composition of bilirubin | |
| CN108721431A (en) | A kind of Chinese medicine composition of re-scheduling metal and its application | |
| CN104491101B (en) | Preparing method of traditional Chinese medicine preparation for treatment of chronic renal failure | |
| CN104645144A (en) | Traditional Chinese medicine preparation for treating nephritis and preparation method of traditional Chinese medicine preparation | |
| CN104491102B (en) | Colon positioning traditional Chinese medicine preparation for treating chronic kidney failure | |
| CN108743885A (en) | A kind of Chinese medicine and preparation method thereof for treating Diabetic Macrovascular Complications | |
| CN116870095B (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN101244127B (en) | Medicament for treating vascular dementia | |
| CN107007710B (en) | Recovery and consciousness restoring granular preparation and preparation method and application thereof | |
| CN105901736A (en) | Application of composition containing green plum extract in preparation of uric acid decreasing healthcare products | |
| CN105395650A (en) | Applications of Shu Gan Ning preparation in preparation of medicines treating osteoporosis and complications of the osteoporosis | |
| CN105816819A (en) | Method for preparing traditional Chinese medicine composition for treating cerebral thrombosis | |
| CN116808128A (en) | Traditional Chinese medicine composition for treating knee osteoarthritis and preparation method and application thereof | |
| CN104258302A (en) | Traditional Chinese medicine for treating chronic idiopathic thrombocytopenic purpura due to fire excess from yin deficiency and preparation method of traditional Chinese medicine | |
| CN117205280A (en) | Medicine for treating acute upper gastrointestinal hemorrhage and preparation method thereof | |
| CN116999515A (en) | Traditional Chinese medicine composition for treating hypertension and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170616 |