CN102188407A - Method for preparing compound Chinese medicine microcapsules - Google Patents
Method for preparing compound Chinese medicine microcapsules Download PDFInfo
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- CN102188407A CN102188407A CN2011101243702A CN201110124370A CN102188407A CN 102188407 A CN102188407 A CN 102188407A CN 2011101243702 A CN2011101243702 A CN 2011101243702A CN 201110124370 A CN201110124370 A CN 201110124370A CN 102188407 A CN102188407 A CN 102188407A
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Abstract
The invention relates to a method for preparing compound Chinese medicine microcapsules, which comprises the following steps: mixing and emulsifying solution of sodium alginate and extract solution of a compound Chinese medicine according to a certain ratio; connecting a positive pole of a high-pressure generator with a needle of an injector, and placing the negative pole of the high-pressure generator at the bottom of solution of calcium chloride; and dripping the emulsified solution into the solution of calcium chloride by a microfluidic injection pump at a constant speed, dispersing and standing for 20 to 40 minutes, washing, and drying to obtain the microcapsules with a particle size smaller than 1,000 mu m. In the method provided by the invention, the raw materials are widely available, the price is low, and the large-scale production is easy; and the capsule wall thickness, size, shape and loading capacity of the obtained microcapsules can be controlled.
Description
Technical field
The present invention relates to a kind of preparation method of herbal mixture microcapsule, belong to medical technical field.
Background technology
Chinese medicine is the rarity of the traditional medicine and the traditional culture of China, and the health for the Chinese nation and the people of the world over thousands of years makes a great contribution.Yet there are problems in Chinese medicine preparation: the bioavailability of (1) current Chinese medicine preparation is very low, causes a large amount of middle pharmaceutically active ingredient wastes; (2) traditional Chinese medicinal tablet, pill, the granule of China exists hygroscopicity strong, easily sliver, problem such as go mouldy more, causes producing in storage, transportation unnecessary resources loss; (3) quite a few Chinese medicine has bad smell, and the patient is difficult to accept; (4) release of Chinese medicine is very unstable, is difficult to reach better curative effect.The problems referred to above press for and are resolved, and the microcapsule technology that developed recently gets up is expected to address these problems.
Microcapsule technology comes from the 1950's, obtains fast development at the mid-1970s, has been widely used in industries such as food, medicine, weaving, petrochemical industry at present.Aspect medical, microcapsule technology can be used for artificial organ development, zooblast, microorganism and enzyme immobilization, medicine sustained release etc.
The Chinese medicine micro encapsulation not only can be overcome the problem that exists in the present Chinese medicine preparation, and can realize targeting, toxic and side effects reduces.The conversion of this dosage form also can be convenient for carrying Chinese medicine as Western medicine, is easy to be accepted by the patient, helps the marketization, the internationalization of Chinese medicine more.
At present, many for the Study on Microencapsulation of single medicinal material, for example with the Oleum Bulbus Allii grease microcapsuleization, well covered its bad smell; With the tea polyphenols micro encapsulation, increased stability of drug; Utilize solid dispersion technology to prepare rhizome of chuanxiong and return and look around drop pill, control drug release reduces " peak, paddy " fluctuation of the blood drug level that causes because of the gradation administration effectively, reaches purpose steady, long-acting release.And for the herbal mixture Study on Microencapsulation, because of its complicated component, it is the report that core prepares microcapsule that Shang Weijian has with the herbal mixture.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of preparation method of herbal mixture microcapsule, controlled, the form distribution rule of prepared microcapsule size.
The preparation method of herbal mixture microcapsule of the present invention comprises the following steps:
(1) takes by weighing the herbal mixture component respectively, boil extraction Chinese medicine with distilled water; The preparation sodium alginate soln, its mass concentration is 0.5%-1.0%;
(2) with sodium alginate soln and herbal mixture extracting solution, 1/2～1/6 ratio by volume, mix homogeneously;
(3) preparation calcium chloride solution, its mass concentration is 5%-8%, adjusting pH is 4-8;
(4) positive pole with high tension generator links to each other with syringe needle, and negative pole is connected to the bottom of calcium chloride solution, and institute's making alive is 4000V-10000V;
(5) mixed solution that step (2) is obtained places in the needle tubing of syringe, is dripped in the calcium chloride solution that step (3) obtains by the piston handle of micro-injection pump pushing syringe, thereby obtains the microcapsule of molding; The microcapsule of molding solidified in calcium chloride solution 20～40 minutes;
(6) separate with calcium chloride solution through solidified microcapsule, wash, be drying to obtain the herbal mixture microcapsule of finished product.
In the such scheme, in sodium alginate soln and the herbal mixture extracting solution mixed process,, can add an amount of surfactant such as polyvinylpyrrolidone (PVP) hydrotropy if be difficult to homodisperse.
Further preferred scheme is:
Syringe needle is 1-8cm apart from the height of calcium chloride solution liquid level.
Syringe needle is No. 6 syringe needles.
The speed that mixed solution is added drop-wise to calcium chloride solution is 1-10 μ l/min.
Compare with methods such as coacervation, interfacial polymerization, situ aggregation methods, the superiority that the high-pressure electrostatic legal system is equipped with microcapsule is to use gentle electrostatic force in microdroplet, and encystation is more uniform and stable, the microcapsule diameter that forms is little, size is more even, smooth surface, encystation rate height.
The present invention as the wall material, is equipped with herbal mixture microcapsule with the high-pressure electrostatic legal system with calcium alginate, the preparation condition gentleness, and the raw material wide material sources, cheap, be easy to large-scale production; The wall thickness of gained microcapsule, size, form, drug loading can be controlled, and have beneficial technical effects.
Description of drawings
The pattern of Fig. 1 embodiment 1 obtained microcapsule
The pattern of Fig. 2 embodiment 2 obtained microcapsules
The specific embodiment
The invention is further illustrated by the following examples, but the present invention is not limited to following embodiment.
Embodiment 1
(1) with the sodium alginate soln of 60 ℃ of distilled water configuration 1wt%, stirred 30 minutes with the speed of 2000rpm, obtain the solution of homogeneous transparent.
(2) capsule-core: the compound kidney-tonifying mixture, at chronic renal failure, take by weighing Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, the Poria of certain mass respectively, boil extraction Chinese medicine with distilled water.
(3) add the herbal mixture extracting solution in sodium alginate soln, the two volume ratio is 1:4, and magnetic agitation makes its mix homogeneously.
(4) the preparation mass concentration is 8% calcium chloride solution, is 5.87 with acid for adjusting pH.
(5) positive pole with high tension generator links to each other with syringe needle, and negative pole is connected to the measuring cup bottom that fills calcium chloride solution, and regulation voltage is to 8000V.
(6) sodium alginate-herbal mixture mixed liquor is placed in the needle tubing of syringe, piston handle by the micro-injection pump pushing syringe, it is 8% that mixed liquor is splashed into mass concentration, pH is in 5.87 the calcium chloride solution, the speed of splashing into is 3 μ l/min, syringe needle is 2cm apart from the height of calcium chloride solution liquid level, and adds magnetic agitation in the calcium chloride solution.Must be spherical smooth, diameter is less than the microcapsule of 1000 μ m.
(7) after the microcapsule of molding solidifies 20 minutes in calcium chloride solution, collect microcapsule, reclaim calcium chloride solution.
(8) through solidified microcapsule distilled water wash, freezing after ,-50 ℃ vacuum drying 8-10 hour, promptly obtain calcium alginate-herbal mixture microcapsule, particle diameter is 1000 μ m.(seeing figure one)
(1) with the sodium alginate soln of 60 ℃ of distilled water configuration 1wt%, stirred 30 minutes with the speed of 2000rpm, obtain the solution of homogeneous transparent.
(2) capsule-core: liquid essence.
(3) add essence in sodium alginate soln, the two volume ratio is 1:1, by adding than 0.5%-2.5%(W/V) add surfactant PVP, magnetic agitation 40 minutes makes its mix homogeneously.
(4) the preparation mass concentration is 5% calcium chloride solution, is 5.87 with acid for adjusting pH.
(5) positive pole with high tension generator links to each other with syringe needle, and negative pole is connected to the measuring cup bottom that fills calcium chloride solution, and regulation voltage is to 6000V.
(6) sodium alginate-essence mixed liquor is placed in the needle tubing of syringe, by the piston handle of micro-injection pump pushing syringe, it is 5% that sodium alginate-essence mixed liquor is splashed into mass concentration, and pH is in 5.87 the calcium chloride solution, must be spherical smooth, diameter is less than the microcapsule of 800 μ m.The speed of splashing into is 3 μ l/min, and syringe needle is 2cm apart from the height of calcium chloride solution liquid level, and adds magnetic agitation in the calcium chloride solution.Syringe needle is No. 6 syringe needles.
(7) after the microcapsule of molding solidifies 40 minutes in calcium chloride solution, collect microcapsule, reclaim calcium chloride solution.
(8) through solidified microcapsule distilled water wash, natural air drying promptly obtains calcium alginate-essence microcapsule, and particle diameter is 800 μ m.(seeing figure two)
Embodiment 3
(1) with the sodium alginate soln of 60 ℃ of distilled water configuration 1wt%, stirred 30 minutes with the speed of 2000rpm, obtain the solution of homogeneous transparent.
(2) capsule-core: liquid essence.
(3) add essence in sodium alginate soln, the two volume ratio is 1:1, by adding than 0.5%-2.5%(W/V) add surfactant PVP, magnetic agitation 40 minutes makes its mix homogeneously.
(4) the preparation mass concentration is 5% calcium chloride solution, and regulating pH with alkali is 7.5.
(5) positive pole with high tension generator links to each other with syringe needle, and negative pole is connected to the measuring cup bottom that fills calcium chloride solution, and regulation voltage is to 4000V.
(6) sodium alginate-essence mixed liquor is placed in the needle tubing of syringe, by the piston handle of micro-injection pump pushing syringe, it is 5% that sodium alginate-essence mixed liquor is splashed into mass concentration, and pH is in 7.5 the calcium chloride solution, must be spherical smooth, diameter is less than the microcapsule of 1000 μ m.The speed of splashing into is 10 μ l/min, and syringe needle is 8cm apart from the height of calcium chloride solution liquid level, and adds magnetic agitation in the calcium chloride solution.Syringe needle is No. 6 syringe needles.
(7) after the microcapsule of molding solidifies 40 minutes in calcium chloride solution, collect microcapsule, reclaim calcium chloride solution.
(8) through solidified microcapsule distilled water wash, natural air drying promptly obtains calcium alginate-essence microcapsule, and particle diameter is 1000 μ m.
Claims (4)
1. the preparation method of a herbal mixture microcapsule is characterized in that comprising the steps:
(1) takes by weighing the herbal mixture component respectively, boil extraction Chinese medicine with distilled water; The preparation sodium alginate soln, its mass concentration is 0.5%-1.0%;
(2) with sodium alginate soln and herbal mixture extracting solution, 1/2～1/6 ratio by volume, mix homogeneously;
(3) preparation calcium chloride solution, its mass concentration is 5%-8%, adjusting pH is 4-8;
(4) positive pole with high tension generator links to each other with syringe needle, and negative pole is connected to the bottom of calcium chloride solution, and institute's making alive is 4000V-10000V;
(5) mixed solution that step (2) is obtained places in the needle tubing of syringe, is dripped in the calcium chloride solution that step (3) obtains by the piston handle of micro-injection pump pushing syringe, thereby obtains the microcapsule of calcium alginate gel form; The microcapsule of molding solidified in calcium chloride solution 20～40 minutes;
(6) separate with calcium chloride solution through solidified microcapsule, wash, be drying to obtain the herbal mixture microcapsule of finished product.
2. preparation method as claimed in claim 1 is characterized in that syringe needle is 1-8cm apart from the height of calcium chloride solution liquid level.
3. preparation method as claimed in claim 1 or 2 is characterized in that syringe needle is No. 6 syringe needles.
4. preparation method as claimed in claim 1 or 2 is characterized in that the speed that mixed solution is added drop-wise to calcium chloride solution is 1-10 μ l/min.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106344538A (en) * | 2016-08-26 | 2017-01-25 | 广州华农大实验兽药有限公司 | Astragalus extract sustained-release microcapsules and preparation method and application thereof |
| CN106853021A (en) * | 2017-03-07 | 2017-06-16 | 广东省第二中医院（广东省中医药工程技术研究院） | Prevent and treat Chinese medicine composition of CKD and its preparation method and application |
| CN107137512A (en) * | 2017-06-29 | 2017-09-08 | 武汉大学 | It is a kind of to treat drug matching of chronic renal failure and preparation method thereof |
| CN107362324A (en) * | 2017-09-06 | 2017-11-21 | 南京苏新智慧社区服务有限公司 | A kind of Chinese medicine sachet of preventing cold strengthening the spleen and stomach and preparation method thereof |
| CN114271538A (en) * | 2021-11-30 | 2022-04-05 | 合肥中科碳微科技有限公司 | Device and method for preparing phase-change microcapsules by microfluidics technology |
| CN114832142A (en) * | 2022-05-07 | 2022-08-02 | 广州润虹医药科技股份有限公司 | Chitosan composite dressing and preparation method thereof |
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| CN2431951Y (en) * | 2000-06-20 | 2001-05-30 | 上海理工大学 | Microcapsule shaping device |
| CN101152623A (en) * | 2006-09-25 | 2008-04-02 | 上海理工大学 | Method for producing liquid core microcapsule by electrostatic spraying |
| CN101716127A (en) * | 2009-12-04 | 2010-06-02 | 上海理工大学 | Method for preparing long-acting and controlled release microencapsulated face cream |
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2011
- 2011-05-16 CN CN2011101243702A patent/CN102188407A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2431951Y (en) * | 2000-06-20 | 2001-05-30 | 上海理工大学 | Microcapsule shaping device |
| CN101152623A (en) * | 2006-09-25 | 2008-04-02 | 上海理工大学 | Method for producing liquid core microcapsule by electrostatic spraying |
| CN101716127A (en) * | 2009-12-04 | 2010-06-02 | 上海理工大学 | Method for preparing long-acting and controlled release microencapsulated face cream |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106344538A (en) * | 2016-08-26 | 2017-01-25 | 广州华农大实验兽药有限公司 | Astragalus extract sustained-release microcapsules and preparation method and application thereof |
| CN106853021A (en) * | 2017-03-07 | 2017-06-16 | 广东省第二中医院（广东省中医药工程技术研究院） | Prevent and treat Chinese medicine composition of CKD and its preparation method and application |
| CN107137512A (en) * | 2017-06-29 | 2017-09-08 | 武汉大学 | It is a kind of to treat drug matching of chronic renal failure and preparation method thereof |
| CN107137512B (en) * | 2017-06-29 | 2021-04-02 | 武汉大学 | Chinese medicinal composition for treating chronic renal failure and preparation method thereof |
| CN107362324A (en) * | 2017-09-06 | 2017-11-21 | 南京苏新智慧社区服务有限公司 | A kind of Chinese medicine sachet of preventing cold strengthening the spleen and stomach and preparation method thereof |
| CN114271538A (en) * | 2021-11-30 | 2022-04-05 | 合肥中科碳微科技有限公司 | Device and method for preparing phase-change microcapsules by microfluidics technology |
| CN114832142A (en) * | 2022-05-07 | 2022-08-02 | 广州润虹医药科技股份有限公司 | Chitosan composite dressing and preparation method thereof |
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Application publication date: 20110921 |