CN102178236A - Blood sugar reducing and cardiovascular and cerebrovascular complication preventing soft capsules and preparation method thereof - Google Patents
Blood sugar reducing and cardiovascular and cerebrovascular complication preventing soft capsules and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of health care products and particularly discloses a blood sugar reducing and cardiovascular and cerebrovascular complication preventing soft capsules and a preparation method thereof. The formula of the preparation consists of astragalus, the root of kudzu vine, ligusticum chuanxiong, root of red-rooted salvia, safflower, fruit of Chinese magnoliavine, balsampear seed, onion, eucommia ulmoides, tea polyphenol, tea oil and propolis. The preparation method comprises extracting functional ingredients of medicinal materials and forming soft capsule preparation. The extraction from the medicinal materials is implemented by supercritical fluid extraction and heating reflux extraction processes to produce essential oil and flavor powder respectively; grinding solid extracts into fine powder by using a colloid mill, fully suspending the fine powder in the essential oil; and the quality of the prepared soft capsules is uniform, the active ingredients of the prepared soft capsules are fully enriched, the bioavailability of the active ingredients is high, and the active ingredients can be absorbed by human bodies effectively. The soft capsules have obvious effects on hyperglycemia, high glucosuria, cardiovascular and cerebrovascular complications, which are caused by diabetes.
Description
Technical field
The invention belongs to health product technology field, be specifically related to capsule health food containing of a kind of hypoglycemic and cardiovascular and cerebrovascular complication and preparation method thereof.
Background technology
Find that according to The World Health Organization (WHO) and IDF (IDE) investigation the whole world had at least 200,000,000 above populations to suffer from diabetes in 2003.China's diabetes number speedup is also very fast, nearly 100,000,000 people of existing sum.Diabetes sharply spread in the world, and its impetus is suddenly, harm is big, become the disaster of " 21 century ".
Diabetes are not fearful, and fearful is diabetic complication, and diabetic complication can cause blood vessel, heart, and nerve, is " the stealthy killer " who makes the people disable, cause death at multiple pathology such as kidney.Long-term hyperglycaemia is the basic reason that leads to complications, because each organotrophy's material equilibrium of supply and demand of human body has been broken in glucose, fat, protein metabolism disorder in patient's body, causes complication.And diabetes patient's blood viscousness often, qi and blood is not smooth, causes that the part visible component precipitates on vascular wall in the blood, causes that vessel wall thickening becomes fragile, capilary is blocked.Add gas loss, the deficiency of vital energy is weak, and unable promotion blood is capable, and hematogenous blockage then causes blood stasis, stagnation of QI-blood, and the retardance mechanism of qi, the channels and collaterals of little blood vessel block, thereby cause various complication, if qi and blood stagnation is in heart and brain, but Zhi Xiong Paralysis is pained, forms diabetic cardiopathy.
The relation of diabetes and complication is a mother-child relationship (MCR), is again sisterhood, but the two has obvious difference; Diabetes are by pancreas islet and emiocytosis pancreas islet relative deficiency or be enough to cause acceptor anything but insulin insensitivity is formed, diabetic complication is because endocrine metabolism, and------is disorderly, free radical spreads unchecked and causes oxidation to be strengthened, the human body basic system can't operate as normal be caused, Diabetes mellitus is a hyperglycaemia, high glucose in urine, complication is a cardiovascular, and pathology takes place kidney etc.; Diabetes can be controlled, but complication can cause heart disease, cerebrovascular disease etc., can make the people disable, cause death.Diabetic complication is unavoidable, but also can control or delay, even can reverse, so research and development are that the control diabetic complication health food of raw material is the task of top priority with Chinese medicine, anything all has principal contradiction and secondary contradiction, hyperglycaemia is to cause the principal contradiction of various complication, control or delay complication, at first must control blood sugar well; Its less important " promoting blood circulation and removing blood stasis ", ancients' cloud: " pain then can not " general rule not bitterly.For the diabetes patient: " general rule is not sick, and disease is then obstructed ".Qi and blood is obstructed, and All kinds of diseases and ailments break out.The diabetes obstinate causes patient's nutrition scarcity, frail, the deficiency of both qi and yin of physique----, causes Blood stasis thus, therefore the diabetic will pay attention to Yin-nourishing and Qi-supplementing especially in control blood sugar, and is promoting blood circulation and removing blood stasis, this is to prevent and treat diabetes development, the criterion of deterioration take place.The control diabetic complication is wanted the key protection point internal organs, for example heart, the cerebrovascular, kidney etc. especially.To early find early prevention, early treatment.
Diabetic cardiomyopathy comprises the diabetic heart vascular lesion, macroangiopathy, myocardium pathology, the caused arrhythmia cordis of cardiac vegetative nerve function of peripheral and cardiac insufficiency.Cause by heart change according to interrelated data report diabetic 80% case fatality rate, be in first of the various causes of death.
Wherein 53% is dead because of merging coronary heart disease, 20-50% dies from the heart infarct, the diabetes patient exceeds 2-4 doubly than the non-diabetic people cardiovascular pathological changes incidence and the death rate, and take place early, development is fast, harm is big, therefore should pay attention to preventing cardiovascular and cerebrovascular complication especially to the diabetic, if solved the diabetes cardiovascular and cerebrovascular complication, therefore will remove the harm of diabetes to a great extent, pressed for these class health products of research and development, except strictness is controlled well the blood sugar, also to actively carry out step-down, transfer fat, fat-reducing, strive up to standard comprehensively.
Therefore the present invention is except that selecting balsampear seed, the fruit of Chinese magnoliavine, onion, tea oil, Tea Polyphenols, propolis etc. to have the obvious blood-sugar lowering tcm drug, the promoting flows of qi and blood circulation such as the Radix Astragali, the root of kudzu vine, the red sage root, Ligusticum wallichii, safflower have been increased, the Chinese medicine of blood-activating analgetic has also increased the Chinese medicine bark of eucommia with obvious step-down, through science compatibility and modern high technology separation and Extraction, make soft capsule, significant effect will be arranged for preventing and treating the diabetic keratopathy cardiovascular and cerebrovascular complication.
Summary of the invention
The purpose of this invention is to provide a kind of capsule health food containing of preventing and treating diabetes cardiovascular and cerebrovascular and disease and preparation method thereof.
The soft capsule of hypoglycemic control cardiovascular and cerebrovascular complication provided by the invention, it is compound Chinese medicinal preparation, its prescription comprises balsampear seed, onion, also comprise the fruit of Chinese magnoliavine, tea-seed oil, Tea Polyphenols, propolis, the Radix Astragali, the root of kudzu vine, the red sage root, Ligusticum wallichii, safflower, the bark of eucommia, described medicinal material materials ratio by weight is: balsampear seed 180-220g, onion 450-550g, fruit of Chinese magnoliavine 250-350g, Tea Polyphenols 45-55g, tea-seed oil 45-55g, propolis 28-32g, Radix Astragali 350-450g, root of kudzu vine 350-450g, red sage root 350-450g, Ligusticum wallichii 350-450g, safflower 180-220g, bark of eucommia 350-450g.
Above-mentioned preparation method of compound soft capsule comprises that the medicinal material functional component extracts and soft capsule preparation.
1, the Chinese medicine functional component extracts:
Balsampear seed, onion, the fruit of Chinese magnoliavine, propolis, tea-seed oil, the red sage root, Ligusticum wallichii, safflower adopt supercritical fluid extraction respectively, and extracting pressure is 25Mpa-35Mpa, extraction temperature 40-70
0C extracts time 1.5h-4h, extract separation and purification; Balsampear seed, onion, the fruit of Chinese magnoliavine, propolis, tea-seed oil, the red sage root, Ligusticum wallichii, safflower are made various Chinese medicine essential oils respectively, propolis is made the smart powder of propolis;
The dregs of a decoction of Tea Polyphenols, the bark of eucommia, the Radix Astragali, root of kudzu vine medicine materical crude slice and above-mentioned various medicinal materials adopt heating and refluxing extraction, the mass concentration of doubly measuring with 4--6 is the ethanol of 70--80%, heating refluxes, extract 2--3 time, each 2--3h gets extract, filtration, decompression and solvent recovery, dry, pulverizing obtain extract powder.
2, soft capsule preparation
The various essential oils that supercritical fluid is obtained mix, and stir, and are heated to 40--50
0C adds an amount of soybean salad oil, stirs evenly, and with the extract fine powder, the smart powder of propolis under agitation adds in the oil, crosses colloid mill, crosses the 80--100 mesh sieve, and repetitive operation 2--3 time makes suspension, 40--50
0The C insulation is stored in the explosive barrel.Gelatin is soaked into gelatin solution, become the gelatin mixed liquor with glycerine, water by the part by weight of 10:4:12, scrape and defoam, deposit in the liquid receiver, the two makes soft capsule, 20--25 by soft glue capsule machine Shang ball
0C places, whole grain, and concentration is the washing of 90% alcohol, dries up, and makes the soft capsule finished product.
The present invention uses the traditional Chinese medical theory using drugs to form a prescription, and the science compatibility is formed compound, multicomponent, multichannel, many target spots, the effect of yielding result altogether adopts supercritical fluid new and high technology and other extracting methods, with the abundant enrichment of functional component, adopt the colloid mill technology that the pressed powder superfine is broken up, is prepared into definite ingredients, quality controllable, effect is obvious, outward appearance is beautiful, bioavilability height, the novel health food of easy absorbed soft capsule.The diabetic cardiomyopathy that this capsule health food containing causes the diabetes patient comprises the heart microvascular pathology, macroangiopathy, and myocardium pathology, the caused rhythm of the heart of heart vegetative nerve artery cardiac insufficiency often all has significant prophylactic-therapeutic effect.Therefore, the present invention is except having remarkable hypoglycemic activity, but also step-down, viscosity reduction, the promoting flow of qi and blood circulation, blood-activating analgetic is prevented and treated the diabetic keratopathy cardiovascular and cerebrovascular complication.
The specific embodiment
One, the prescription of soft capsule of the present invention, the consumption of each component according to the present invention, preferred following 3 prescriptions:
Prescription 1: balsampear seed 180g, Radix Astragali 350g, onion 450g, root of kudzu vine 350g, fruit of Chinese magnoliavine 250g, tea oil 45g, propolis 28g, safflower 180g, Tea Polyphenols 45g, red sage root 350g, Ligusticum wallichii 350g, bark of eucommia 350g.
Prescription 2: balsampear seed 200g, Radix Astragali 400g, onion 500g, root of kudzu vine 400g, fruit of Chinese magnoliavine 300g, tea oil 50g, propolis 30g, safflower 200g, Tea Polyphenols 50g, red sage root 400g, Ligusticum wallichii 400g, bark of eucommia 400g.
Prescription 3: balsampear seed 220g, Radix Astragali 450g, onion 55g, root of kudzu vine 450g, the sub-350g of bitter taste, tea oil 55g, propolis 32g, safflower 220g, Tea Polyphenols 55g, red sage root 450g, Ligusticum wallichii 450g, bark of eucommia 450g.
Two, preparation of soft capsule of the present invention:
1, the extraction of Chinese medicine functional component
(1) supercritical fluid extraction of balsampear seed:
Balsampear seed is pulverized, be loaded in the supercritical fluid extraction jar extracting pressure 25 ~ 30Mpa, extraction temperature 40 ~ 45
0C, extraction time 2 ~ 3h, extract extract, separate and to remove moisture, the balsampear seed essential oil.
(2) supercritical fluid extraction of onion:
Onion is loaded in the supercritical fluid extraction jar extracting pressure 14 ~ 16Mpa, extraction temperature 30 ~ 35
0C, extraction time 4 ~ 5h, extract extract, separate and to remove moisture, onion essential oil.
(3) extraction of the supercritical fluid of propolis:
Propolis is loaded in the supercritical fluid extraction jar, extracting pressure 28 ~ 32Mpa, extraction temperature 50 ~ 60
0C, extraction time 2 ~ 3h extracts to such an extent that extract is the smart powder of propolis.
(4) supercritical fluid extraction of tea-seed oil:
The tea seed is pulverized, and is loaded in the supercritical fluid extraction jar extracting pressure 28 ~ 32Mpa, extraction temperature 50 ~ 60
0C, extraction time 3 ~ 4h, extract extract, separate and to remove moisture, tea-seed oil.
(5) safflower supercritical fluid extraction;
Safflower is loaded in the super stream circle fluid extraction jar extracting pressure 25 ~ 35Mpa, extraction temperature 50 ~ 60
0C, extraction time 1.5 ~ 2.5h obtains extract, separates and removes moisture, gets the safflower essential oil.
(6) supercritical fluid extraction of the red sage root:
Be broken into meal at danshen powder, be loaded in the supercritical fluid extraction jar, at extracting pressure 30 ~ 35Mpa, extraction temperature 60 ~ 70
0C, extraction time 1.5 ~ 2.5h adds the extraction of 95% ethanol entrainer, obtains extract, reclaims ethanol, and cooling, filtration, decompression, drying obtain tanshinone
The A extract.
(7) supercritical fluid extraction of Ligusticum wallichii:
The Ligusticum wallichii pulverizing medicinal materials is become meal, be loaded in the supercritical fluid extraction jar, at extracting pressure 30 ~ 35Mpa, extraction temperature 70 ~ 75
0C, extraction time 2 ~ 3h, extraction obtains extract, separates and removes moisture, gets brownish red Ligusticum wallichii essential oil.
(8) supercritical fluid extraction of the fruit of Chinese magnoliavine:
The fruit of Chinese magnoliavine is placed the supercritical fluid extraction jar, extracting pressure 25 ~ 35Mpa, extraction temperature 55 ~ 65
0C, extraction time 1 ~ 2h, extract extract, extract separated removes moisture, obtain fruit of Chinese magnoliavine essential oil.
(9) dregs of a decoction of Tea Polyphenols, the bark of eucommia, the Radix Astragali, root of kudzu vine medicine materical crude slice and above-mentioned various medicinal materials adopt heating and refluxing extraction, the mass concentration of doubly measuring with 4--6 is the ethanol of 70--80%, heating refluxes, extract 2 times, each 2--3h gets extract, filtration, decompression and solvent recovery, dry, pulverizing obtain extract powder.
2, soft capsule preparation
The various essential oils that supercritical fluid is obtained mix, and stir, and are heated to 40--50
0C adds an amount of soybean salad oil, stirs evenly, and with the extract fine powder, the smart powder of propolis under agitation adds in the oil, crosses colloid mill, crosses 100 mesh sieves, and repetitive operation 3 times makes suspension, 40--50
0The C insulation is stored in the explosive barrel.Gelatin is soaked into gelatin solution, become the gelatin mixed liquor with glycerine, water by the part by weight of 10:4:12, scrape and defoam, deposit in the liquid receiver, the two makes soft capsule, 20 by soft glue capsule machine Shang ball
0C places, whole grain, and concentration is the washing of 90% alcohol, dries up, and makes the soft capsule finished product.
Three, the quality index of soft capsule of the present invention
Interventions Requested standard-required index
Tanshinone IIA mg/ grain 〉=1-2mg
Forulic acid mg/ grain 〉=0.1-0.2mg
Moisture %≤7
Ash content %≤9
Arsenic (in As) mg/kg≤1.0
Plumbous (in Pb) mg/kg≤1.0
Mercury (in As) mg/kg≤0.3
Disintegration time limited min≤60
Oxidation number %≤2.0
Acid value 40
Total plate count cfu/g≤1000
Large intestine bacterium colony MpN/100g≤40
Mould cfu/g≤25
Saccharomycete cfu/g≤25
Pathogenic bacteria (salmonella, Shigella, golden yellow
Staphylococcus, hemolytic streptococcus) must not detect.
Four, soft capsule Determination on content of the present invention
(1) assay of the red sage root (employing high performance liquid chromatography)
Chromatographic condition and system suitability test: with the 18 alkyl silica gel bonded silica gel is filler, and with methyl alcohol: water (82:18) is the phase that flows, and detections wavelength is 254nm, and theoretical cam curve is pressed tanshinone IIA calculating, should be not less than 3000.
The preparation of reference substance solution: take by weighing the tanshinone IIA reference substance about 5mg of 50 ℃ of vacuum drying to constant weight, the accurate title, decide, and places the 50ml volumetric flask, adds methyl alcohol-carrene (1:1) solution and be diluted to scale, shakes up; Precision is measured in the brown measuring bottle of above-mentioned solution 1.0ml to 100ml, adds methyl alcohol-carrene (1:1) solution and is diluted to scale, shakes up, and promptly gets (to contain the tanshinone II among every 1ml
A1 μ g).
The preparation of need testing solution: get the content mixing under this product content uniformity, take by weighing about 0.3g, the accurate title, decide, and places the brown measuring bottle of 50ml, is diluted to scale with carrene, shake up, filter, precision is measured in the brown measuring bottle of subsequent filtrate 1.0ml to 50ml, adds methyl alcohol-carrene (1:1) solution and is diluted to scale, shake up, promptly.
Assay method: accurate respectively reference substance solution, the need testing solution 10 μ l of drawing, inject liquid chromatograph, measure, promptly.
Every of this product is by containing the red sage root with the tanshinone II
A(C
19H
18O
3) meter, must not be less than 1-2mg.
(2) content of ferulic acid is measured (employing high performance liquid chromatography) in the Ligusticum wallichii
Chromatographic condition and system suitability test: with the 18 alkyl silica gel bonded silica gel is filler, is the phase that flows (35:65) with methyl alcohol-water (10% glacial acetic acid), and the detection wavelength is 320nm, and theoretical cam curve is pressed forulic acid and calculated, and should be not less than 4000.
The preparation of reference substance solution: take by weighing the about 5mg of forulic acid reference substance, accurate claim surely, place the 50ml volumetric flask, with mobile phased soln and be diluted to scale, shake up; Precision is measured in above-mentioned solution 1.0ml to the 25ml measuring bottle, adds the phase dilution that flows to scale, shakes up, promptly.
The preparation of need testing solution: get the content mixing under this product content uniformity, take by weighing about 0.3g, the accurate title, decide, and places the 5ml measuring bottle, uses the phase dilution that flows to scale, shake up, filter, precision is measured in the brown measuring bottle of subsequent filtrate 1.0ml to 10ml, adds methyl alcohol-carrene (1:1) solution and is diluted to scale, shake up, promptly.
Assay method: accurate respectively reference substance solution, the need testing solution 10 μ l of drawing, inject liquid chromatograph, measure, promptly.
Every of this product is by containing Ligusticum wallichii with forulic acid (C
10H
10O
4) meter, must not be less than 0.1-0.2mg.
Claims (6)
1. the soft capsule of the anti-cardiovascular and cerebrovascular complication of a hypoglycemic, it is characterized in that being compound Chinese medicinal preparation, its prescription comprises medicinal material: balsampear seed, onion, the fruit of Chinese magnoliavine, tea-seed oil, Tea Polyphenols, propolis, the Radix Astragali, the root of kudzu vine, the red sage root, Ligusticum wallichii, the safflower and the bark of eucommia, described medicinal material materials ratio by weight is: balsampear seed 180-220g, onion 450-550g, fruit of Chinese magnoliavine 250-350g, Tea Polyphenols 45-55g, tea-seed oil 45-55g, propolis 28-32g, Radix Astragali 350-450g, root of kudzu vine 350-450g, red sage root 350-450g, Ligusticum wallichii 350-450g, safflower 180-220g, bark of eucommia 350-450g.
2. the soft capsule of the anti-cardiovascular and cerebrovascular complication of hypoglycemic according to claim 1 is characterized in that its prescription is: balsampear seed 180g, onion 450g, fruit of Chinese magnoliavine 250g, Tea Polyphenols 45g, tea oil 45g, propolis 28g, the Radix Astragali 350 g, root of kudzu vine 350g, red sage root 350g, Ligusticum wallichii 350g, safflower 180g, bark of eucommia 350g.
3. the soft capsule of the anti-cardiovascular and cerebrovascular complication of hypoglycemic according to claim 1 is characterized in that its prescription is: balsampear seed 200g, onion 500g, fruit of Chinese magnoliavine 300g, Tea Polyphenols 50g, tea oil 50g, propolis 30g, the Radix Astragali 400 g, root of kudzu vine 400g, red sage root 400g, Ligusticum wallichii 400g, safflower 200g, bark of eucommia 400g.
4. the soft capsule of the anti-cardiovascular and cerebrovascular complication of hypoglycemic according to claim 1 is characterized in that its prescription is: balsampear seed 220g, onion 550g, fruit of Chinese magnoliavine 350g, Tea Polyphenols 55g, tea oil 55g, propolis 32g, the Radix Astragali 450 g, root of kudzu vine 450g, red sage root 450g, Ligusticum wallichii 450g, safflower 220g, bark of eucommia 450g.
5. as the preparation of soft capsule method of the anti-cardiovascular and cerebrovascular complication of the described hypoglycemic of one of claim 1-4, it is characterized in that comprising that the medicinal material functional component extracts and soft capsule preparation, wherein:
(1), the medicinal material functional component extracts:
Balsampear seed, onion, the fruit of Chinese magnoliavine, propolis, tea-seed oil, the red sage root, Ligusticum wallichii, safflower adopt supercritical fluid extraction respectively, and extracting pressure is 25Mpa-35Mpa, extraction temperature 40
0C-70
0C extracts time 1.5h-4h, extract separation and purification; Balsampear seed, onion, the fruit of Chinese magnoliavine, propolis, tea-seed oil, the red sage root, Ligusticum wallichii, safflower are made various Chinese medicine essential oils respectively, propolis is made the smart powder of propolis;
The dregs of a decoction of Tea Polyphenols, the bark of eucommia, the Radix Astragali, root of kudzu vine medicine materical crude slice and above-mentioned various medicinal materials adopt heating and refluxing extraction, the mass concentration of doubly measuring with 4--6 is the ethanol of 70%--80%, heating refluxes, extract 2--3 time, each 2 h--3h gets extract, filtration, decompression and solvent recovery, dry, pulverizing obtain extract powder;
(2), soft capsule preparation:
The various essential oils that supercritical fluid is obtained mix, and stir, and are heated to 40
0C--50
0C adds an amount of soybean salad oil, stirs evenly, and with the extract fine powder, the smart powder of propolis under agitation adds in the oil, crosses colloid mill, crosses the 80--100 mesh sieve, and repetitive operation 2--3 time makes suspension, and 40
0C--50
0The C insulation; Gelatin is soaked into gelatin solution, is that the part by weight of 10:4:12 is mixed into the gelatin mixed liquor by gelatin and glycerine, water, adds a small amount of colouring agent iron oxide; Above-mentioned two parts are made soft capsule, 20--25 by Ruan Jiao Nang Ji Shang ball
0C places, and whole grain is the washing of 90% alcohol with concentration, dries up, and makes the soft capsule finished product.
6. according to the preparation of soft capsule method of the anti-cardiovascular and cerebrovascular complication of the described hypoglycemic of claim, it is characterized in that the condition of each Chinese medicine supercritical fluid extraction is:
(1) supercritical fluid extraction of balsampear seed:
Balsampear seed is pulverized, be loaded in the supercritical fluid extraction jar extracting pressure 25 Mpa ~ 30Mpa, extraction temperature 40
0C ~ 45
0C, extraction time 2 h ~ 3h, extract extract, separate and to remove moisture, the balsampear seed essential oil;
(2) supercritical fluid extraction of onion:
Onion is loaded in the supercritical fluid extraction jar extracting pressure 14 Mpa ~ 16Mpa, extraction temperature 30
0C ~ 35
0C, extraction time 4 h ~ 5h, extract extract, separate and to remove moisture, onion essential oil;
(3) extraction of the supercritical fluid of propolis:
Propolis is loaded in the supercritical fluid extraction jar, extracting pressure 28 Mpa ~ 32Mpa, extraction temperature 50
0C ~ 60
0C, extraction time 2 h ~ 3h extract to such an extent that extract is the smart powder of propolis;
(4) supercritical fluid extraction of tea-seed oil:
The tea seed is pulverized, and is loaded in the supercritical fluid extraction jar extracting pressure 28 Mpa ~ 32Mpa, extraction temperature 50
0C ~ 60
0C, extraction time 3 h ~ 4h, extract extract, separate and to remove moisture, tea-seed oil;
(5) safflower supercritical fluid extraction:
Safflower is loaded in the super stream circle fluid extraction jar extracting pressure 25 Mpa ~ 35Mpa, extraction temperature 50
0C ~ 60
0C, extraction time 1.5 h ~ 2.5h obtain extract, separate and remove moisture, get the safflower essential oil;
(6) supercritical fluid extraction of the red sage root:
Be broken into meal at danshen powder, be loaded in the supercritical fluid extraction jar, at extracting pressure 30 Mpa ~ 35Mpa, extraction temperature 60
0C ~ 70
0C, extraction time 1.5 h ~ 2.5h add the extraction of 95% ethanol entrainer, obtain extract, reclaim ethanol, and cooling, filtration, decompression, drying obtain tanshinone
The A extract;
(7) supercritical fluid extraction of Ligusticum wallichii:
The Ligusticum wallichii pulverizing medicinal materials is become meal, be loaded in the supercritical fluid extraction jar, at extracting pressure 30 Mpa ~ 35Mpa, extraction temperature 70
0C ~ 75
0C, extraction time 2 h ~ 3h, extraction obtains extract, separates and removes moisture, gets brownish red Ligusticum wallichii essential oil;
(8) supercritical fluid extraction of the fruit of Chinese magnoliavine:
The fruit of Chinese magnoliavine is placed the supercritical fluid extraction jar, extracting pressure 25 Mpa ~ 35Mpa, extraction temperature 55
0C ~ 65
0C, extraction time 1 h ~ 2h, extract extract, extract separated removes moisture, obtain fruit of Chinese magnoliavine essential oil.
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|---|---|---|---|
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311557A (en) * | 2015-02-16 | 2016-02-10 | 辽宁格林生物药业集团股份有限公司 | Method for preparing Qinhuang capsules for laryngeal symptoms and application of Qinhuang capsules |
| CN105831733A (en) * | 2016-03-23 | 2016-08-10 | 管天球 | Tea oil lipid reducing capsule |
| CN107173812A (en) * | 2017-07-14 | 2017-09-19 | 贵州省苑博生态农业开发有限公司 | A kind of Kiwi fruit health product and preparation method thereof |
| CN111454774A (en) * | 2020-04-26 | 2020-07-28 | 五邑大学 | Method for extracting plant essential oil with hypoglycemic activity |
-
2011
- 2011-04-28 CN CN2011101082861A patent/CN102178236A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311557A (en) * | 2015-02-16 | 2016-02-10 | 辽宁格林生物药业集团股份有限公司 | Method for preparing Qinhuang capsules for laryngeal symptoms and application of Qinhuang capsules |
| CN105831733A (en) * | 2016-03-23 | 2016-08-10 | 管天球 | Tea oil lipid reducing capsule |
| CN107173812A (en) * | 2017-07-14 | 2017-09-19 | 贵州省苑博生态农业开发有限公司 | A kind of Kiwi fruit health product and preparation method thereof |
| CN111454774A (en) * | 2020-04-26 | 2020-07-28 | 五邑大学 | Method for extracting plant essential oil with hypoglycemic activity |
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Application publication date: 20110914 |