CN103495083B - Compound traditional Chinese medicine micro powder dry suspension for livestock and preparation method thereof - Google Patents
Compound traditional Chinese medicine micro powder dry suspension for livestock and preparation method thereof Download PDFInfo
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a compound traditional Chinese medicine micro powder dry suspension for livestock. The compound traditional Chinese medicine micro powder dry suspension for livestock comprises the following raw materials in parts by weight: 10-40 parts of hawthorn, 10-40 parts of malt, 10-40 parts of medicated leaven, 1-20 parts of betel nut, 0.1-5 parts of wetting agent, and 1-10 parts of suspending agent. A preparation method of the compound traditional Chinese medicine micro powder dry suspension for livestock comprises the following steps of (1) respectively putting the hawthorn, malt, medicated leaven, and betel nuts in a pulverizer and smashing, screening by a 300-mesh sieve, and obtaining the traditional Chinese medicine ultra-fine powder; and (2) weighing ultra-fine powder of the hawthorn, malt, medicated leaven and betel nuts in parts by weight, adding the wetting agent and the suspending agent, and mixing uniformly and completely. The preparation method combines an ultra-fine powder technology and a suspension preparation technology, and a proper amount of stabilizer is added in the traditional Chinese medicine ultra-fine powder so as to prepare the dry suspension, so that the defect that the ultra-fine powder cannot be mixed for drinking is overcome, the amount of labor is lowered, the dosage is reduced, and the feeding cost is saved.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to compound traditional Chinese medicine micro powder dry suspension of a kind of poultry use and preparation method thereof.
Background technology
Study on Supermicro-pulverization of Traditional Chinese Drugs mainly refers to the cellular level pulverizing of Chinese crude drug, is directly smashed by the cell of Chinese crude drug.Active ingredient due to plant amedica, animal drugs is mainly distributed in cell and intercellular substance, based in cell, therefore will break comminution process for the purpose of Chinese crude drug cell and be called " cellular level pulverizing " of Chinese medicine; The micro-powder of Chinese herbs adopting cellular level pulverizing method to obtain is called cell grade micro-powder of Chinese herbs; By micronizing, the medium particle diameter of virgin materials can be brought up to more than 300 orders from 150 ~ 200 orders of traditional handicraft, for general medical material, the cell-wall breaking ratio under this fineness condition is greater than 95%.Cell intracellular composition that can be saved after breaking cellular wall fully comes out, the rate of release of medicine and burst size can significantly improve.Chinese medicine is after superfine communication technique is pulverized, and diameter is less than 10 μm (namely more than 300 orders), and ultrastructurepower technology is the industrial technology of the high-tech content of powder body, has that speed is fast, the time is short, particle diameter is thin, is evenly distributed, the feature such as conservation.
But the Chinese medicine powder that ultrastructurepower technology obtains can not dissolve in water, spice administration can only be passed through, because medicine is pulverized very thin, electrostatic attraction between drug particle is more much bigger than common Chinese powder, and medicine is easily sticked together, therefore, easily occur during spice mixing uneven phenomenon, and by mixed feeding administration, feedstuff can have a negative impact to the performance of drug effect, mixed feeding administration often needs to strengthen dosage just can reach therapeutic effect.
Suspensoid refers to that insoluble solid medicine is scattered in the liquid preparation heterogeneous formed in disperse medium with graininess.Suspensoid drug particles is generally between 0.5 ~ 10 μm, and the suspensoid that character is stable can dispersed and unlikely sinking in water for a long time.
Summary of the invention
The object of this invention is to provide one can the compound traditional Chinese medicine micro powder dry suspension that uses of homodisperse in water, the poultry that can mix drink and preparation method thereof.
For achieving the above object, the present invention take technical scheme be, the compound traditional Chinese medicine micro powder dry suspension that poultry use, the parts by weight of each raw material are: Fructus Crataegi 10 ~ 40 parts, 10 ~ 40 parts, Fructus Hordei Germinatus, Massa Medicata Fermentata 10 ~ 40 parts, Semen Arecae 1 ~ 20 part, wetting agent 0.1 ~ 5 part, suspending agent 1 ~ 10 part.
Described wetting agent can be one or more in soybean lecithin, PEG6000, polyoxyethylene hydrogenated Oleum Ricini, dodecyl sodium sulfate, Myrj 52.
Described suspending agent can be one or more in hypromellose, agar, PVPk17, sodium carboxymethyl cellulose, poloxamer, xanthan gum, guar gum, gelatin.
The preparation method of the compound traditional Chinese medicine micro powder dry suspension that described poultry use, comprises the following steps: (1), by Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata, Semen Arecae, is placed in multifunctional crusher respectively and pulverizes, and crosses 300 mesh sieves, namely obtains the superfine powder of each Chinese medicinal components; (2) take the superfine powder of Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata, Semen Arecae according to described parts by weight, add wetting agent and the suspending agent of described parts by weight, abundant mix homogeneously.
Described Chinese medicine ultra-fine powder particle diameter is 1 ~ 10 μm.
The invention has the beneficial effects as follows, ultrastructurepower technology and suspension formulation combine with technique get up by the present invention, in Chinese medicine ultra-fine powder, add suitable stabilizing agent be made into dry suspension, thus solve the defect that superfine powder can not mix drink, reduce the amount of labour, additionally reduce dosage, save feeding cost.
Detailed description of the invention
Embodiment 1
Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata, Semen Arecae 4 taste Chinese herbal medicine are placed in multifunctional crusher respectively and pulverize, crosses 300 mesh sieves, obtain the superfine powder that particle diameter is each Chinese medicinal components of 1 ~ 10 μm; Get the superfine powder of each Chinese medicinal components respectively: Fructus Crataegi 200 grams, 200 grams, Fructus Hordei Germinatus, Massa Medicata Fermentata 300 grams, Semen Arecae 150 grams; Then mix homogeneously with 50 grams of soybean lecithins and 100 grams of hypromelloses, get product.
Embodiment 2
Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata, Semen Arecae 4 taste Chinese herbal medicine are placed in multifunctional crusher respectively and pulverize, crosses 300 mesh sieves, obtain the superfine powder that particle diameter is each Chinese medicinal components of 1 ~ 10 μm; Get the superfine powder of each Chinese medicinal components respectively: Fructus Crataegi 100 grams, 100 grams, Fructus Hordei Germinatus, Massa Medicata Fermentata 400 grams, Semen Arecae 200 grams; Then mix homogeneously with 1 gram of dodecyl sodium sulfate and 40 grams of xanthan gum, get product.
Embodiment 3
Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata, Semen Arecae 4 taste Chinese herbal medicine are placed in multifunctional crusher and pulverize, crosses 300 mesh sieves, obtain the superfine powder of each Chinese medicinal components of 1 ~ 10 μm; Get the superfine powder of each Chinese medicinal components respectively: Fructus Crataegi 400 grams, 400 grams, Fructus Hordei Germinatus, Massa Medicata Fermentata 100 grams, Semen Arecae 10 grams; Then mix homogeneously with 20 grams of polyoxyethylene castor oils and 10 grams of poloxamers, get product.
Application test
Select 9 health and without digestive tract medical history 2-5 year grow up cattle as laboratory animal, laboratory animal is divided at random three groups, often organize 3.Common Chinese group, every Traditional Chinese drug mixture that every day, 200g prepared in the ratio of Chinese medicinal components each in the embodiment of the present invention 1, Ordinary pulverization; Micropowder suspensoid group, every finished product prepared in the 100g embodiment of the present invention 1 every day; Matched group, not medication.Test period is 5 days.
Under laboratory animal is placed in normal feeding environment, matched group regularly extracts rumen fluid from cud every day after feeding 2h, measures indices; Common Chinese group, timing micropowder suspensoid group every day are fed Chinese herbal medicine before feeding, Chinese herbal medicine are dissolved in 300ml warm water and gavage to animal, extract rumen fluid after feeding 2h, measure indices.
PH value adopts acidometer to measure; In rumen fluid, the activity of microorganism utilizes methylene blue redox reaction method to measure, at room temperature get three test tubes, one adds rumen fluid as blank, common Chinese group, micropowder suspensoid group first add the methylene blue solution of 1ml 0.03% respectively, add 20ml rumen fluid again, leave standstill, and timing, observe and return to the colourless required time; Ciliate determination of activity, by a cud drop on clean slide, ciliate mobility observed by low power lens, represents (plus sige quantity is more, and mobility is stronger) with plus sige; The content of volatile fatty acid, with gas chromatography determination; The mensuration of the protein of protozoa matter content, rumen fluid is filtered, get the centrifugal 10min of 5ml filtrate, precipitation being added 9ml mass concentration is centrifugal 10min after 10% solution of trichloroacetic acid stirs, precipitate being added mass fraction is that 5%NaOH solution dilution is to 25ml, centrifugal 10min, gets supernatant on ultraviolet spectrophotometer by 280nm and 260nm wavelength colorimetric.
Compound traditional Chinese medicine micro powder dry suspension and the impact of ordinary powder on Rumen physiology index of poultry use are as shown in table 1:
The compound traditional Chinese medicine micro powder dry suspension that table 1. poultry use and ordinary powder are on the impact of Rumen physiology index
Result shows, gavages compound traditional Chinese medicine micro powder dry suspension that poultry of the present invention use can strengthen the active and microbiological oxidation reduction reaction of ciliate in its cud to cattle, pH value without significant change, the content increase of the protein of protozoa.Micro powder dry suspension group is compared with ordinary powder group, the effect strengthening microbiological oxidation reduction reaction is more remarkable, the content of volatile fatty acid and the protein of protozoa significantly increases, significant difference, therefore, micro powder dry suspension agent more can promote the growth of animal, fattens, increase weight, and improves feed efficiency, shortens breeding cycle.The increased activity of microorganism in cud and Vfa Concentration improve the energy source by ensureing ruminant, the anabolism of body is strengthened, is conducive to the growth of animal.
Claims (3)
1. a compound traditional Chinese medicine micro powder dry suspension for poultry use, it is characterized in that, the parts by weight of each raw material are: Fructus Crataegi 10 ~ 40 parts, 10 ~ 40 parts, Fructus Hordei Germinatus, Massa Medicata Fermentata 10 ~ 40 parts, Semen Arecae 1 ~ 20 part, wetting agent 0.1 ~ 5 part, suspending agent 1 ~ 10 part; Described wetting agent is one or more in soybean lecithin, PEG6000, polyoxyethylene hydrogenated Oleum Ricini, dodecyl sodium sulfate, Myrj 52; Described suspending agent is one or more in hypromellose, agar, PVPk17, sodium carboxymethyl cellulose, poloxamer, xanthan gum, guar gum, gelatin.
2. the preparation method of the compound traditional Chinese medicine micro powder dry suspension of poultry use according to claim 1, it is characterized in that, comprise the following steps: (1), by Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata, Semen Arecae, is placed in multifunctional crusher respectively and pulverizes, cross 300 mesh sieves, namely obtain the superfine powder of each Chinese medicinal components; (2) take the superfine powder of Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata, Semen Arecae according to described parts by weight, add wetting agent and the suspending agent of described parts by weight, abundant mix homogeneously.
3. the preparation method of the compound traditional Chinese medicine micro powder dry suspension of poultry use as claimed in claim 2, it is characterized in that, the superfine powder particle diameter of described each Chinese medicinal components is 1 ~ 10 μm.
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| CN105998116A (en) * | 2016-06-23 | 2016-10-12 | 勾大卉 | Radix notoginseng dry suspension and preparation method thereof |
| CN111450206A (en) * | 2020-04-10 | 2020-07-28 | 四川恺多萌宠文化传播有限公司 | Composition for improving pet oral odor and preparation method thereof |
| CN113750191A (en) * | 2021-10-12 | 2021-12-07 | 河北坤元饲料有限公司 | Chinese herbal medicine stomach-invigorating composition for ruminant feed and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1120941A (en) * | 1994-10-21 | 1996-04-24 | 山东临清中药厂 | Stomachic tablet and its production method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1120941A (en) * | 1994-10-21 | 1996-04-24 | 山东临清中药厂 | Stomachic tablet and its production method |
Non-Patent Citations (1)
| Title |
|---|
| 健胃胶囊对胃液分泌及小肠吸收功能影响的实验研究;何岚等;《中医药学刊》;20050210;第23卷(第02期);320,383 * |
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