CN2431951Y - Microcapsule shaping device - Google Patents
Microcapsule shaping device Download PDFInfo
- Publication number
- CN2431951Y CN2431951Y CN 00218100 CN00218100U CN2431951Y CN 2431951 Y CN2431951 Y CN 2431951Y CN 00218100 CN00218100 CN 00218100 CN 00218100 U CN00218100 U CN 00218100U CN 2431951 Y CN2431951 Y CN 2431951Y
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- China
- Prior art keywords
- syringe
- propeller
- glass container
- sleeve
- model
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- Medicinal Preparation (AREA)
Abstract
The utility model relates to a miniature capsule forming device. The utility model is characterized in that the utility model is composed of a high voltage electric field generator, a propeller, a syringe, a glass container and a bracket; the propeller is connected with a sleeve barrel of the bracket and is connected with the syringe; a slide block is connected with a plunger piston; the glass container is arranged under a needle of the syringe; the positive pole of the high voltage generator is connected with the needle of the syringe, and the negative pole is put at the bottom of the glass container. The device has the advantages that the utility model can manufacture miniature capsules which have consistent sizes, consistent shapes and high smooth surface quality; the utility model has simple operation and can be conveniently regulated, assembled and disassembled, can manufacture miniature capsules with proper sizes according to need and can satisfy the need of the fields of foods, medicine and biological engineering.
Description
The utility model relates to and a kind of pharmaceuticals, food and industrial chemicals is called the microcapsules shaped device that the micro-capsule heartwood is wrapped up.
Microcapsules technology is to utilize natural or synthetic macromolecular material as micro-capsule wall material, pharmaceuticals, food and the industrial chemicals of solid, liquid is called the micro-capsule heartwood wraps up, and makes a kind of new technology, the new technology of micron order or nano_scale particle product.Since the invention thirties in 20th century, the microcapsules technology research and development is rapid, is applied at numerous areas such as medicine, food, fine chemistry industries in succession.Microcapsules have the influence that the protection material is avoided environmental condition, and covering smell and color reduce toxicity; improve the machinability and the stability of material; prolong the volatile materials storage time, delay or control the release of capsule core material, functions such as the compound isolation that can not mix.In recent years, food, medical circle utilize microcapsules technology that biomaterials such as enzyme, bacterium and cell are carried out microencapsulation, can improve its quality, widen its range of application.For example Bifidobacterium Bifidum is adopted sodium alginate to carry out microencapsulation, make it arrive enteron aisle by stomach after, the dissolving of microcapsules cyst wall, Bifidobacterium Bifidum discharges, can more effective prevention and treatment intestines problem; Transplantation treatment diabetes after utilizing microcapsules technology to the islet cells microencapsulation can solve the immunological rejection problem effectively, can reach immunity and isolate, prolong the graft purpose of life cycle, can realize allogeneic and heterograft.Replace long term injections insulin, the microencapsulation islet cell transplantation is a kind of Perfected process of treatment diabetes.Yet, implement this technology, still there is not a kind of comparatively ideal microcapsules shaped device at present, and what at present Bifidobacterium Bifidum and islet cells are carried out that microencapsulation adopted is that orifice is squeezed into bag apparatus and air-flowing type encystation device, these two kinds device prepared microcapsule particle diameters are bigger, and dimensional homogeneity, shape uniformity are relatively poor.As the Bifidobacterium Bifidum microcapsules particle diameter of using orifice method preparation is 4～6mm, because the microcapsules particle diameter is bigger, should not add in numerous food, limits its range of application; Utilize the islet cells microcapsules of air-flowing type preparation, big or small uniformity is relatively poor, and rough, the out-of-shape of surface of microcapsule influences transplantation effect to a certain extent.
The utility model purpose is in order to overcome the shortcoming of prior art, providing a kind of utilizes the high-voltage electrostatic field and advances extrusion technique, can preparation size uniformity, be shaped as spheroidal, smooth surface, the shaped device of the microcapsules that are of moderate size, to satisfy the application need of food industry and medical science aspect.
The technical solution of the utility model is the microcapsules shaped device by the propeller of the adjustable high voltage electric field generator of voltage, adjustable-speed, syringe, glass container and is configured to, propeller is connected on the sleeve of support, syringe is fixedlyed connected with propeller, angle of rake slide block moving up and down is connected with plunger in the syringe, glass container places the syringe needle below, the positive pole of high pressure generator is connected with syringe needle, and negative pole is placed on the glass container bottom.
Scheme of the present utility model is based on the micro-capsule heartwood solution that places syringe with propeller with certain speed pushing downwards, and under the high voltage electrostatic field that produces by the high voltage electric field generator, micro-capsule heartwood solution overcomes viscous force and surface tension, the drop that is certain particle diameter falls into the glass container that fills solution, be solidified into water-fast micro gel bead, become microcapsules through chemical treatment again.Therefore, the advantage of this device is microcapsule size, the shape unanimity of preparation, smooth surface quality height; This device is simple to operate, the adjustment easy accessibility; Can prepare the microcapsules that are of moderate size as required, minimum microcapsule diameter can reach 150 μ m, can satisfy the needs that food, medicine and bioengineering field prepare microcapsules.
The utility model embodiment is described further in conjunction with the accompanying drawings.
Fig. 1 is a microcapsules shaped device structure principle chart.
By shown in Figure 1, the microcapsules shaped device is made of propeller 7, syringe 3, glass container 1 and the support 13 of the adjustable high voltage electric field generator 15 of 0～10kV, adjustable-speed, propeller 7 is connected on the sleeve 11 of support, syringe 3 is fixedlyed connected with propeller 7, the slide block moving up and down 5 of propeller 7 is connected with plunger 4 in the syringe, glass container 1 places syringe needle 2 belows, the positive pole 12 of high voltage electric field generator is connected with syringe needle 2 with clip by lead, and negative pole is placed on glass container 1 bottom.Support is made of sleeve 11 and vertical bar 8, sleeve 11 is enclosed within on the vertical bar 8, and by screw 10 location, sleeve can axially move up and down along vertical bar, to regulate in syringe needle and the glass container distance between liquid level, propeller comprises slide block 5, leading screw 6 and small machine, and slide block set is on leading screw, and propeller drives leading screw by small machine and rotates, pass through electric machine speed regulation, the speed that the slide block that is enclosed within on the leading screw can 1～99mm/h is moved along leading screw, and propeller adopts clothes-hook 9 to connect with sleeve, can be for convenience detach.Plunger 4 ends of syringe 3 may be stuck in the groove on the slide block 5, are moved by the mobile drive plunger of slide block; Lug on the syringe urceolus is inserted in the groove of propeller shell, so that axial location.Syringe is inserted in the collar on the propeller, and the collar plays the radial location effect.Syringe needle on the syringe and urceolus adopt plug type to connect, as required the syringe needle of conveniently replaced different model.The pin top of syringe needle is concordant head.In order to promote high production rate, can adopt the spininess head to annotate device.In use, after each parts connected on request, the voltage of high voltage electric field generator is adjusted to 5kV, propeller slide block translational speed is adjusted into 50mm/h, by regulating sleeve, with in needle tip and the measuring cup between liquid level distance be adjusted to 20mm; Adopting its diameter of bore of 7# syringe needle is 0.28mm, sucks solution in the syringe and be concentration and be 1.5% the sodium alginate soln and the mixture of islet cells, fills calcium chloride solution in the glass container.Under the effect of propeller extruding and electric field force, the sodium alginate soln that is mixed with islet cells falls into calcium chloride solution with tiny drop, and being solidified into particle diameter is 200 μ m, and size is even, spheroidal, ganoid islet cells microcapsules.
Claims (4)
1, a kind of microcapsules shaped device, it is characterized in that, it is by the adjustable high voltage electric field generator (15) of voltage, the propeller of adjustable-speed (7), syringe (3), glass container (1) and support (13) constitute, propeller (7) is connected on the sleeve (11) of support, syringe (3) is fixedlyed connected with propeller (7), the slide block moving up and down (5) of propeller (7) is connected with plunger (4) in the syringe, glass container (1) places syringe needle (2) below, the positive pole of high pressure generator (12) is connected with syringe needle (2), and negative pole is placed on glass container 1 bottom.
2, microcapsules shaped device according to claim 1, it is characterized in that, described support (13) is made of sleeve (11) and vertical bar (8), sleeve (11), be enclosed within on the vertical bar (8), and by screw (10) location, sleeve can axially move up and down along vertical bar, to regulate in syringe needle and the glass container distance between liquid level.
3, microcapsules shaped device according to claim 1, it is characterized in that described propeller (7) comprises slide block (5), leading screw (6) and small machine, slide block set is on leading screw, propeller drives leading screw by small machine and rotates, and propeller (7) adopts hook (9) to connect with sleeve (11).
4, microcapsules shaped device according to claim 1 is characterized in that, described syringe (3) can be the spininess syringe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00218100 CN2431951Y (en) | 2000-06-20 | 2000-06-20 | Microcapsule shaping device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00218100 CN2431951Y (en) | 2000-06-20 | 2000-06-20 | Microcapsule shaping device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2431951Y true CN2431951Y (en) | 2001-05-30 |
Family
ID=33583554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00218100 Expired - Fee Related CN2431951Y (en) | 2000-06-20 | 2000-06-20 | Microcapsule shaping device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2431951Y (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100488618C (en) * | 2006-09-25 | 2009-05-20 | 上海理工大学 | Method for producing liquid core microcapsule by electrostatic spraying |
| CN102188407A (en) * | 2011-05-16 | 2011-09-21 | 武汉大学 | Method for preparing compound Chinese medicine microcapsules |
| CN103495210A (en) * | 2013-09-26 | 2014-01-08 | 福州大学 | Chitosan-hydroxylapatite in-situ loaded icariin composite microspheres |
| CN104324676A (en) * | 2014-11-14 | 2015-02-04 | 上海理工大学 | Microcapsule generation device |
| CN104328106A (en) * | 2014-08-25 | 2015-02-04 | 湖南中医药大学 | Microcapsule preparation apparatus and method |
| CN106622055A (en) * | 2016-10-18 | 2017-05-10 | 上海理工大学 | Preparation device of high-voltage electric field microcapsules |
| CN108543503A (en) * | 2018-05-10 | 2018-09-18 | 上海理工大学 | A kind of microcapsules generating means |
-
2000
- 2000-06-20 CN CN 00218100 patent/CN2431951Y/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100488618C (en) * | 2006-09-25 | 2009-05-20 | 上海理工大学 | Method for producing liquid core microcapsule by electrostatic spraying |
| CN102188407A (en) * | 2011-05-16 | 2011-09-21 | 武汉大学 | Method for preparing compound Chinese medicine microcapsules |
| CN103495210A (en) * | 2013-09-26 | 2014-01-08 | 福州大学 | Chitosan-hydroxylapatite in-situ loaded icariin composite microspheres |
| CN103495210B (en) * | 2013-09-26 | 2015-03-04 | 福州大学 | Chitosan-hydroxylapatite in-situ loaded icariin composite microspheres |
| CN104328106A (en) * | 2014-08-25 | 2015-02-04 | 湖南中医药大学 | Microcapsule preparation apparatus and method |
| CN104324676A (en) * | 2014-11-14 | 2015-02-04 | 上海理工大学 | Microcapsule generation device |
| CN106622055A (en) * | 2016-10-18 | 2017-05-10 | 上海理工大学 | Preparation device of high-voltage electric field microcapsules |
| CN108543503A (en) * | 2018-05-10 | 2018-09-18 | 上海理工大学 | A kind of microcapsules generating means |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |