CN102908959B - Semi-automatic microcapsule forming device - Google Patents
Semi-automatic microcapsule forming device Download PDFInfo
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- CN102908959B CN102908959B CN201210295457.0A CN201210295457A CN102908959B CN 102908959 B CN102908959 B CN 102908959B CN 201210295457 A CN201210295457 A CN 201210295457A CN 102908959 B CN102908959 B CN 102908959B
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Abstract
The invention relates to a semi-automatic microcapsule forming device, belonging to the technical field of biological pharmacy and microbial ecological agent manufacturing. According to the semi-automatic microcapsule forming device disclosed by the invention, a motor is dominated by a regulating device; and when the semi-automatic microcapsule forming device runs, the motor enables a belt to drive a rotary disc to rotate, a single screw rod ascends or descends along with the rotation of the rotary disc, a syringe with a syringe needle is inserted into a syringe sleeve which is welded on a support plate, a propulsion plate is welded at the tail end of the single screw rod, the syringe is extruded to generate a microcapsule, and a beaker containing a calcium chloride solution is arranged below the syringe needle and is stirred by a magnetic stirrer. The semi-automatic microcapsule forming device has low cost, is convenient to operate, is energy-saving, is environment-friendly and is equipped with the regulating device so as to regulate the extrusion time, the extrusion frequency and the microcapsule size, thus truly realizing the semi-automation function, and therefore, the semi-automatic microcapsule forming device is suitable for preparing a great amount of microcapsules in a laboratory.
Description
Technical field
The present invention relates to a kind of semi-automatic microcapsule shaping device, belong to bio-pharmaceuticals and probiotics manufacturing technology field.
Background technology
Antibiotic is controlled most bacteriosis, but has also produced many side effects, is mainly that human body is developed immunity to drugs, and normal flora imbalance, suppresses organism immune response formation etc.Probiotics is also active bacteria formulation, refers to use microecology principle, utilizes the growth promoting substance to the useful and harmless probio of host or probio, the preparation of making through special process.Oneself is applied to current probiotics in each fields such as feed, agricultural, medicines and health protection and food.In feed industry, extensive use has Lactobacillus plantarum, a bacillus subtilis etc., and in food, extensive use has lactic acid bacteria, Bifidobacterium, enterococcus and a saccharomycete etc.Important microbe in enteron aisle is when reaching some (>10
7cfu/g) time, can improve, regulate the balance of microorganism species in host's enteron aisle.Active bacteria formulation (liquid) viable count in several days order of magnitude that will decline.For bacterium dry powder, the very fast inactivation of storage meeting under general room temperature, viable count can decline in a large number.
Microcapsules technology is that one is relatively new and develop pharmaceutical technology rapidly, utilize natural or synthetic macromolecular material, by solid, to be wrapped in diameter be in a kind of microencapsulation with semipermeable or sealing cyst membrane within the scope of 1～500 μ m for liquid etc., be applicable to the more sensitive material of light, heat, oxygen and humidity ratio.Using the probiotics that microcapsules technology makes, to have shelf life long, acid resistance, and enteric solubility, bile tolerance, the feature such as high temperature resistant, Microencapsulation Method is the most common with extrusion in suitability for industrialized production.
When extrusion is prepared microcapsule formulation, add the dopes such as sodium alginate due to need, while therefore pushing syringe, only with the hands extruding is very difficult.The device of preparing microcapsules both domestic and external is being carried out to discovery after investigation, most of installation cost is expensive, framework complexity, complex operation step.In addition, existing device is mostly to design for single syringe, and the output of microcapsules is little, inefficiency.CN1958147A discloses a kind of " simple and easy microcapsules generating means ", it adopts three mouthfuls of air shearing force generating means to make the particle diameter of microcapsules in 300 ~ 500um left and right, particle size range is extensive, lower than external microcapsules preparation facilities cost, but this device needs pressure and air compressor two place's external force means, this has strengthened production cost undoubtedly, this patent at the supply mode of pressure without any narration, production efficiency is had no way of evaluating and microcapsule size is played a decisive role setting forth the volume of mentioning liquid core when operation principle, so three mouthfuls of air cutting force generators are loads that the advantages outweigh the disadvantages, and pass into air and be unfavorable for sterile production, producing compressed air needs mass energy to be unfavorable for energy-conserving and environment-protective.ZL00218100.2 discloses a kind of " electrostatic technique/high drive microcapsule shaping device ", and as what set forth in CN1958147A, it is expensive, and technology is immature, realizes commercialization difficulty.And domestic microcapsules device is all too simple and easy on programming even not to be had, thus need people to regulate and control, not humane, virtually cause the waste of human resources.
External product is as the design classics of Switzerland Nisco microencapsulated system, but reliable in quality price is high, is also not suitable for domestic large industrialized and produces.
Summary of the invention
High being difficult to of use cost for domestic and international microcapsule shaping device popularized; Domestic static microcapsule shaping device technology is immature; The easy microbiological contamination of three mouthfuls of air shearing force microcapsules generating means, not energy-conservation problem, the invention provides a kind of semi-automatic microcapsules generating means.
The technical scheme that the present invention adopted is for achieving the above object: semi-automatic microcapsule shaping device, on multiple angle bar, weld the heavy frame constituent apparatus base of plane, welding support on heavy frame, support upper end has screw to mate with single screw rod, the bottom of single screw rod is welded with pushing plate, support is connected with turntable bearing, and rotating disk connects motor by belt, and motor is by regulation device control.
Described heavy frame is used for placing gripper shoe.
In described gripper shoe, be welded with the syringe jacket for supporting syringe.
Described syringe jacket outside is without the columniform stainless steel sleeve of upper bottom surface, and internal diameter matches with injector wall size; In stainless steel sleeve inner bottom surface, be the plastic pipe sleeve matching with syringe top size, stainless steel sleeve bottom center is useful on the syringe bore of holding syringe needle.
Described syringe bore internal diameter is slightly larger than syringe needle, and there is Rubber washer inner side.
Described angle bar regulates length as required, thereby regulates the distance of syringe needle and below liquid level of solution.
Described support is the square angle bar perpendicular to heavy frame.
Described regulation device comprises Intelligent timer 1, pressure regulator, Intelligent timer 2, K1 switch, K2 switch, transformer, electric bridge and four disjunctor switches, described four disjunctor switches connect motor and electric bridge, one side of the other end connection transformer of electric bridge, the opposite side of transformer is connected in series Intelligent timer 1, pressure regulator, Intelligent timer 2, K1 switch, and described Intelligent timer 2 is parallel with K2 switch.
The present invention has the following advantages:
1. designed regulation device, not only can also be set interval time according to concentration design fashion of extrusion, extruding amplitude, speed, the frequency of solution, realized only need setting the semi-automation that program just can no worker monitor and produce;
2. high in extruding concentration, when the solution of utmost point thickness, can be according to principle of inertia, by inertia, increase the feasibility of industrialized production by direction operating key and fast moving key;
3. the distance of syringe needle and liquid level is a key factor that changes microcapsules quality, and angle bar height is adjustable, makes this factor controlled;
4. the quantity of the syringe jacket in gripper shoe can increase as required or reduce, and is conducive to produce in enormous quantities;
5. the syringe needle varying in size by replacement, controls particle diameter, and in the time producing with No. 4 syringe needles, the Microcapsules Size of generation is 100 μ m left and right, and even is smooth, reaches the advanced level of same kind of products at abroad;
6. there is larger practicality, be applicable to most microcapsules suitability for industrialized production raw material;
7. direction operating key and fast moving key not only can push the higher solution of concentration by inertia, can also dismantle by regulation and control, change syringe;
8. cost is low, easy and simple to handle, energy-conserving and environment-protective, and particle diameter is adjustable, and possesses regulation device, has really realized semi-automatic function, is suitable for laboratory and prepares large quantity of micro-capsule.
Brief description of the drawings
Fig. 1 is the structural representation of syringe jacket in the present invention;
Fig. 2 is the fundamental diagram of apparatus of the present invention
Fig. 3 is regulation device schematic diagram.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is described in further detail.
Technical scheme of the present invention is that regulation device 11, single screw rod 6, pushing plate 4, syringe jacket 3, heavy frame 12, support 5, the angle bar 1 adjustable by program forms, support 5 upper ends have screw 5-1 to mate with single screw rod 6, switch on power, regulate and control by regulation device 11, motor 9 drives belt 8 turn rotating disks 7, rotating disk 7 drives single screw rod 6, single screw rod 6 welds together with pushing plate 4, multiple syringes with syringe needle are inserted in the syringe jacket 3 in gripper shoe 2, and angle bar 1 and heavy frame 12 prop up gripper shoe 2.When moving down, pushing plate 4 on syringe, produces pressure, the syringe needle of syringe is fixed in the syringe bore 3-1 in syringe jacket 3, syringe jacket 3 in gripper shoe 2 has designed the Rubber washer of applicable syringe size, syringe bore 3-1, such advantage is, shares pressure, makes syringe not yielding, cutting the gripper shoe 2 of having welded syringe jacket 3 can disassemble, and has facilitated the installation of syringe.Heavy frame 12 props up pressure and produces microcapsules.
As shown in Figure 1, syringe jacket 3 in present embodiment is made up of syringe bore 3-1, plastic pipe sleeve 3-2, stainless steel sleeve 3-3, syringe bore 3-1 presses the size design of stainless steel syringe needle base, can just hold syringe needle, syringe needle can not come off because pressure is excessive, plastic pipe sleeve 3-2 presses the size design of syringe top, effect is that pressure is disperseed, syringe can not fractureed because pressure is excessive, and stainless steel sleeve 3-3 presses the design of injector wall size, for fixing syringe.
As shown in Figures 2 and 3, semi-automatic microcapsule shaping device in present embodiment is made up of the adjustable regulation device 11 of program, single screw rod 6, pushing plate 4, syringe jacket 3, heavy frame 12, support 5, angle bar 1, support 5 upper ends have screw 5-1 to mate with single screw rod 6, connect K1 switch, regulate and control by regulation device 11, motor 9 drives belt 8 turn rotating disks 7, rotating disk 7 drives single screw rod 6, single screw rod 6 welds together with pushing plate 4, multiple syringes with syringe needle are inserted in the syringe jacket 3 in gripper shoe 2, and angle bar 1 and heavy frame 12 prop up gripper shoe 2.When moving down, pushing plate 4 on syringe, produces pressure, the syringe needle of syringe is fixed in the syringe bore 3-1 in syringe jacket 3, syringe jacket in gripper shoe 2 has designed the syringe bore 3-1 of applicable syringe size, plastic pipe sleeve 3-2, stainless steel sleeve 3-3, such advantage is, share pressure, make syringe not yielding, fixing syringe, the gripper shoe 2 of having welded syringe jacket 3 can disassemble, so that the installation of syringe.Heavy frame 12 props up pressure and produces microcapsules.
Regulation device 11 comprises Intelligent timer 1, pressure regulator, Intelligent timer 2, K1 switch, K2 switch, transformer, electric bridge and four disjunctor switches, described four disjunctor switches connect motor 9 and electric bridge, one side of the other end connection transformer of electric bridge, the opposite side of transformer is connected in series intelligent switch, pressure regulator, Intelligent timer, K1 switch, and described Intelligent timer is parallel with K2 switch.Wherein, K1 switch is the power switch of regulation device 11; Intelligent timer 1 is selected the HC-202C_ of system in Beijing Jing Hui Chuan instrument Science and Technology Ltd., for working time countdown regulation and control and the regulation and control of work total time, the time of this device work and the time of rest can be set; Pressure regulator is a rheostat; Intelligent timer 2 is selected the HC-202C_ of system in Beijing Jing Hui Chuan instrument Science and Technology Ltd., for extrusion time countdown regulation and control and the regulation and control of interval total time; In the time that K2 switch is closed, can pass through to change rheostatic resistance, and then change the power of motor 9, realize moving up and down fast of pushing plate 4; The transformation scope of transformer is 24-220V; Electric bridge is selected the R-10VA of Shanghai Shen Zheng Electronics Co., Ltd.; Four disjunctor switches are selected the ZN48 of Changzhou Yin Shi hundred happy Electronics Co., Ltd.s, by changing the positive negative direction of input voltage of motor 9, and then control the direction that moves up and down of pushing plate 4.
Its advantage is, can regulate and control production frequency according to manufacturing schedule.It is continuously extruded or interruption extruding that extrusion time countdown regulation and control and the regulation and control of interval total time can arrange the mode of production according to the proterties of solution, in the time being arranged to be interrupted extruding, can also select to push frequency and extrusion time, improve the practicality of this device, be applicable to most microcapsules suitability for industrialized production raw material.Direction control and fast moving control not only can be pushed the higher solution of concentration by inertia, can also dismantle by regulation and control, change syringe.
When solution selects to fill the 60mL needle tubing of 50mL2% sodium alginate, during with No. 4 syringe needle extruding, selecting extrusion time is 1 second, 20 seconds interval times, extruding amplitude is adjusted to that to become to be 30 degree angles the most suitable with the vertical direction of switch, net cycle time is 40min, estimates within 3 hours, to continue extruding after extrusion technique, and it is 3 hours that interval total time is set.
Operation principle: the volume of liquid core plays a decisive role to microcapsule size, drop flows out at syringe needle place, in the time that the gravity of microcapsules itself has been greater than the surface tension of viscous effect, drop just falls, when the projected area of syringe needle changes, surface tension also changes thereupon, and the large surface tension in aperture is large, and microcapsules need to can fall in the time that volume is larger, the little surface tension in aperture is little, when microcapsules small volume, just falls.
Meanwhile, the surface tension of liquid and its viscosity also have relation, and motor control assembly can regulate propelling amplitude, and the present invention can realize the microcapsules making of various concentration liquid like this.
Claims (5)
1. a semi-automatic microcapsule shaping device, it is characterized in that, heavy frame (12) the constituent apparatus base of the upper welding of multiple angle bar (1) plane, the upper welding support (5) of heavy frame (12), support (5) upper end has screw (5-1) to mate with single screw rod (6), the bottom of single screw rod (6) is welded with pushing plate (4), support (5) is connected with rotating disk (7) bearing, rotating disk (7) connects motor (9) by belt (8), and motor (9) is controlled by regulation device (11);
Described heavy frame (12) is for placing gripper shoe (2);
In described gripper shoe (2), be welded with the syringe jacket (3) for supporting syringe;
Described syringe jacket (3) outside is without the columniform stainless steel sleeve of upper bottom surface (3-3), and internal diameter matches with injector wall size; In stainless steel sleeve (3-3) inner bottom surface, be the plastic pipe sleeve (3-2) matching with syringe top size, stainless steel sleeve (3-3) bottom center is useful on the syringe bore (3-1) of holding syringe needle.
2. semi-automatic microcapsule shaping device according to claim 1, is characterized in that, described syringe bore (3-1) internal diameter is slightly larger than syringe needle, and there is Rubber washer inner side.
3. semi-automatic microcapsule shaping device according to claim 1, is characterized in that, described angle bar (1) regulates length as required, thereby regulates the distance of syringe needle and below liquid level of solution.
4. semi-automatic microcapsule shaping device according to claim 1, is characterized in that, described support (5) is the square angle bar perpendicular to heavy frame (12).
5. semi-automatic microcapsule shaping device according to claim 1, it is characterized in that, described regulation device (11) comprises Intelligent timer 1, pressure regulator, Intelligent timer 2, K1 switch, K2 switch, transformer, electric bridge and four disjunctor switches, described four disjunctor switches connect motor (9) and electric bridge, one side of the other end connection transformer of electric bridge, the opposite side of transformer is connected in series Intelligent timer 1, pressure regulator, Intelligent timer 2, K1 switch, and described Intelligent timer 2 is parallel with K2 switch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210295457.0A CN102908959B (en) | 2012-08-17 | 2012-08-17 | Semi-automatic microcapsule forming device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210295457.0A CN102908959B (en) | 2012-08-17 | 2012-08-17 | Semi-automatic microcapsule forming device |
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| CN102908959A CN102908959A (en) | 2013-02-06 |
| CN102908959B true CN102908959B (en) | 2014-07-23 |
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| CN201210295457.0A Active CN102908959B (en) | 2012-08-17 | 2012-08-17 | Semi-automatic microcapsule forming device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103634120A (en) * | 2013-12-18 | 2014-03-12 | 上海市数字证书认证中心有限公司 | Method and system for real-name authentication based on face recognition |
| CN110102230A (en) * | 2019-05-13 | 2019-08-09 | 广东省微生物研究所（广东省微生物分析检测中心） | A kind of automatic microcapsules Granulation Equipments of squash type and preparation method thereof |
| CN115430372B (en) * | 2022-08-18 | 2023-08-04 | 中国地质大学（武汉） | Three-dimensional porous attapulgite microsphere and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2237457Y (en) * | 1995-09-18 | 1996-10-16 | 钟力 | Syringe propeller |
| CN2481324Y (en) * | 2001-06-26 | 2002-03-13 | 上海金晓科技发展有限公司 | Vertical capsule forming device |
| CN2576470Y (en) * | 2002-11-13 | 2003-10-01 | 青岛天利达橡塑机械有限公司 | Mould-moving back-pushing type capsule injection former |
-
2012
- 2012-08-17 CN CN201210295457.0A patent/CN102908959B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2237457Y (en) * | 1995-09-18 | 1996-10-16 | 钟力 | Syringe propeller |
| CN2481324Y (en) * | 2001-06-26 | 2002-03-13 | 上海金晓科技发展有限公司 | Vertical capsule forming device |
| CN2576470Y (en) * | 2002-11-13 | 2003-10-01 | 青岛天利达橡塑机械有限公司 | Mould-moving back-pushing type capsule injection former |
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| CN102908959A (en) | 2013-02-06 |
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