CN105037454A - 一种异麦芽酮糖醇晶体的制备方法 - Google Patents
一种异麦芽酮糖醇晶体的制备方法 Download PDFInfo
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- CN105037454A CN105037454A CN201510431560.7A CN201510431560A CN105037454A CN 105037454 A CN105037454 A CN 105037454A CN 201510431560 A CN201510431560 A CN 201510431560A CN 105037454 A CN105037454 A CN 105037454A
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- organic solvent
- preparation
- hydroxyl isomaltulose
- palatinitol
- volatile organic
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- 239000013078 crystal Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 title abstract description 17
- 239000003960 organic solvent Substances 0.000 claims abstract description 38
- 238000000034 method Methods 0.000 claims abstract description 33
- 239000007787 solid Substances 0.000 claims abstract description 23
- 238000001816 cooling Methods 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 52
- -1 hydroxyl isomaltulose Chemical compound 0.000 claims description 49
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 claims description 32
- SERLAGPUMNYUCK-YJOKQAJESA-N 6-O-alpha-D-glucopyranosyl-D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-YJOKQAJESA-N 0.000 claims description 27
- 230000001476 alcoholic effect Effects 0.000 claims description 27
- 238000004448 titration Methods 0.000 claims description 23
- 238000009413 insulation Methods 0.000 claims description 17
- 238000009833 condensation Methods 0.000 claims description 3
- 230000005494 condensation Effects 0.000 claims description 3
- 238000007605 air drying Methods 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 abstract description 5
- 238000005469 granulation Methods 0.000 abstract description 5
- 230000003179 granulation Effects 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 abstract description 4
- 238000001694 spray drying Methods 0.000 abstract description 3
- 238000004321 preservation Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 34
- 239000000463 material Substances 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 238000002425 crystallisation Methods 0.000 description 12
- 230000008025 crystallization Effects 0.000 description 10
- 239000000843 powder Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 238000001704 evaporation Methods 0.000 description 6
- 230000008020 evaporation Effects 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- 239000000905 isomalt Substances 0.000 description 6
- 235000010439 isomalt Nutrition 0.000 description 6
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 6
- 150000005846 sugar alcohols Chemical class 0.000 description 4
- 238000013022 venting Methods 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 229960004793 sucrose Drugs 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000007670 refining Methods 0.000 description 2
- 229960002920 sorbitol Drugs 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- SERLAGPUMNYUCK-BLEZHGCXSA-N (2xi)-6-O-alpha-D-glucopyranosyl-D-arabino-hexitol Chemical compound OCC(O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-BLEZHGCXSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- PPWHTZKZQNXVAE-UHFFFAOYSA-N Tetracaine hydrochloride Chemical compound Cl.CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 PPWHTZKZQNXVAE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000011552 falling film Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 239000010413 mother solution Substances 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000006200 vaporizer Substances 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
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Abstract
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109608509A (zh) * | 2018-12-10 | 2019-04-12 | 浙江华康药业股份有限公司 | 一种颗粒状异麦芽酮糖醇的连续制备方法 |
CN110171808A (zh) * | 2019-07-09 | 2019-08-27 | 乐山师范学院 | 一种球粒状固体磷酸的制备装置及其制备方法 |
CN113004346A (zh) * | 2021-02-07 | 2021-06-22 | 济南茂腾生物科技有限公司 | 一种负压耦合常压结晶制备木糖的方法 |
Citations (6)
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CN1275574A (zh) * | 2000-04-17 | 2000-12-06 | 范志刚 | 一种帕拉金糖醇的制备方法 |
CN101591689A (zh) * | 2009-06-30 | 2009-12-02 | 广西投资集团维科特生物技术有限公司 | 生物酶法转化蔗糖生产异麦芽酮糖的方法 |
CN101759729A (zh) * | 2009-12-29 | 2010-06-30 | 殴劳福林(天津)工业有限公司 | 一种生产异麦芽酮糖醇晶体的方法 |
CN101781341A (zh) * | 2009-12-29 | 2010-07-21 | 殴劳福林(天津)工业有限公司 | 一种生产异麦芽酮糖醇晶体的工艺方法 |
CN102286454A (zh) * | 2011-07-01 | 2011-12-21 | 广西科学院生物研究所 | 聚乙烯醇固定产蔗糖异构酶菌体制备异麦芽酮糖方法 |
CN102964399A (zh) * | 2012-11-23 | 2013-03-13 | 浙江华康药业股份有限公司 | 一种异麦芽酮糖醇粉的制备方法 |
-
2015
- 2015-07-21 CN CN201510431560.7A patent/CN105037454B/zh active Active
Patent Citations (6)
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CN1275574A (zh) * | 2000-04-17 | 2000-12-06 | 范志刚 | 一种帕拉金糖醇的制备方法 |
CN101591689A (zh) * | 2009-06-30 | 2009-12-02 | 广西投资集团维科特生物技术有限公司 | 生物酶法转化蔗糖生产异麦芽酮糖的方法 |
CN101759729A (zh) * | 2009-12-29 | 2010-06-30 | 殴劳福林(天津)工业有限公司 | 一种生产异麦芽酮糖醇晶体的方法 |
CN101781341A (zh) * | 2009-12-29 | 2010-07-21 | 殴劳福林(天津)工业有限公司 | 一种生产异麦芽酮糖醇晶体的工艺方法 |
CN102286454A (zh) * | 2011-07-01 | 2011-12-21 | 广西科学院生物研究所 | 聚乙烯醇固定产蔗糖异构酶菌体制备异麦芽酮糖方法 |
CN102964399A (zh) * | 2012-11-23 | 2013-03-13 | 浙江华康药业股份有限公司 | 一种异麦芽酮糖醇粉的制备方法 |
Non-Patent Citations (1)
Title |
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苏雪梅.: "异麦芽酮糖醇的生产工艺及其设备选型.", 《中国调味品》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109608509A (zh) * | 2018-12-10 | 2019-04-12 | 浙江华康药业股份有限公司 | 一种颗粒状异麦芽酮糖醇的连续制备方法 |
CN110171808A (zh) * | 2019-07-09 | 2019-08-27 | 乐山师范学院 | 一种球粒状固体磷酸的制备装置及其制备方法 |
CN113004346A (zh) * | 2021-02-07 | 2021-06-22 | 济南茂腾生物科技有限公司 | 一种负压耦合常压结晶制备木糖的方法 |
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Denomination of invention: Preparation method for palatinitol crystals Effective date of registration: 20180109 Granted publication date: 20171003 Pledgee: Yucheng Shandong rural commercial bank Limited by Share Ltd Pledgor: Shandong Lvjian Biological Technology Co., Ltd. Registration number: 2018370000010 |
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