CN105031353B - A kind of logical Chinese medicine preparation of heart and brain - Google Patents
A kind of logical Chinese medicine preparation of heart and brain Download PDFInfo
- Publication number
- CN105031353B CN105031353B CN201510491700.XA CN201510491700A CN105031353B CN 105031353 B CN105031353 B CN 105031353B CN 201510491700 A CN201510491700 A CN 201510491700A CN 105031353 B CN105031353 B CN 105031353B
- Authority
- CN
- China
- Prior art keywords
- kilograms
- chinese medicine
- kilogram
- medicine preparation
- heart
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 82
- 238000002360 preparation method Methods 0.000 title claims abstract description 49
- 210000002216 heart Anatomy 0.000 title claims abstract description 34
- 210000004556 brain Anatomy 0.000 title claims abstract description 30
- 241000220324 Pyrus Species 0.000 claims abstract description 25
- 241000208340 Araliaceae Species 0.000 claims abstract description 23
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 23
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 23
- 235000008434 ginseng Nutrition 0.000 claims abstract description 23
- 235000021017 pears Nutrition 0.000 claims abstract description 23
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 20
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 20
- 241000756943 Codonopsis Species 0.000 claims abstract description 19
- 241000545744 Hirudinea Species 0.000 claims abstract description 17
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 16
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 16
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 16
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 15
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 14
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 14
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 14
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 14
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 14
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 14
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 14
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 14
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 14
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 14
- 240000000171 Crataegus monogyna Species 0.000 claims abstract 5
- 244000234609 Portulaca oleracea Species 0.000 claims abstract 5
- 239000002775 capsule Substances 0.000 claims description 17
- 241000245665 Taraxacum Species 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 230000033228 biological regulation Effects 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 3
- 230000000857 drug effect Effects 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 238000009495 sugar coating Methods 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 2
- 238000003860 storage Methods 0.000 claims description 2
- 241001247821 Ziziphus Species 0.000 claims 6
- 244000126002 Ziziphus vulgaris Species 0.000 abstract description 19
- 208000026106 cerebrovascular disease Diseases 0.000 abstract description 18
- 230000002526 effect on cardiovascular system Effects 0.000 abstract description 12
- 208000024172 Cardiovascular disease Diseases 0.000 abstract description 11
- 208000029078 coronary artery disease Diseases 0.000 abstract description 11
- 206010008118 cerebral infarction Diseases 0.000 abstract description 10
- 230000001225 therapeutic effect Effects 0.000 abstract description 9
- 240000001949 Taraxacum officinale Species 0.000 abstract description 2
- 238000011282 treatment Methods 0.000 description 31
- 230000000694 effects Effects 0.000 description 28
- 239000008280 blood Substances 0.000 description 21
- 210000004369 blood Anatomy 0.000 description 21
- 230000006870 function Effects 0.000 description 20
- 241000219304 Portulacaceae Species 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 210000000952 spleen Anatomy 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 11
- 235000009508 confectionery Nutrition 0.000 description 10
- 241001092040 Crataegus Species 0.000 description 9
- 210000003414 extremity Anatomy 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 210000002784 stomach Anatomy 0.000 description 9
- 230000036772 blood pressure Effects 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 8
- 206010002383 Angina Pectoris Diseases 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 7
- 208000002193 Pain Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 206010033799 Paralysis Diseases 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 206010067484 Adverse reaction Diseases 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000006838 adverse reaction Effects 0.000 description 3
- 206010003549 asthenia Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 229960003711 glyceryl trinitrate Drugs 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 235000019605 sweet taste sensations Nutrition 0.000 description 3
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 description 2
- 208000008457 Neurologic Manifestations Diseases 0.000 description 2
- YSEXMKHXIOCEJA-FVFQAYNVSA-N Nicergoline Chemical compound C([C@@H]1C[C@]2([C@H](N(C)C1)CC=1C3=C2C=CC=C3N(C)C=1)OC)OC(=O)C1=CN=CC(Br)=C1 YSEXMKHXIOCEJA-FVFQAYNVSA-N 0.000 description 2
- 235000014443 Pyrus communis Nutrition 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 235000008529 Ziziphus vulgaris Nutrition 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229910052796 boron Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 239000008899 fufang danshen Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 230000004217 heart function Effects 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 230000007971 neurological deficit Effects 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001256 tonic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 206010061623 Adverse drug reaction Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010003211 Arteriosclerosis coronary artery Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 208000034710 Cerebral arteriovenous malformation Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 208000034657 Convalescence Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000002263 Intracranial Arteriovenous Malformations Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028836 Neck pain Diseases 0.000 description 1
- 101000858051 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) Adenylate cyclase Proteins 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000218633 Pinidae Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 201000000034 arteriovenous malformations of the brain Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000004227 basal ganglia Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 238000009933 burial Methods 0.000 description 1
- 239000000496 cardiotonic agent Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000001709 ictal effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 239000004223 monosodium glutamate Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000010825 pathological waste Substances 0.000 description 1
- 208000001297 phlebitis Diseases 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of heart and brain to lead to Chinese medicine preparation, and the formula counted according to unit of weight part is：7 ~ 10 kilograms of Radix Codonopsis, 1~2 kilogram of hawthorn, 9 ~ 16 kilograms of ginseng, excessively crisp 7 ~ 10 kilograms of the pears of king, 8 ~ 16 kilograms of Radix Notoginseng, 1 ~ 2 kilogram of Jishan plate jujube, 5 ~ 8 kilograms of leech, 1 ~ 2 kilogram of Shanxi south Fructus Tritici Levis, 5 ~ 8 kilograms of amber, 1~2 kilogram of Radix Glycyrrhizae, 8 ~ 16 kilograms of pueraria lobata, 3 ~ 6 kilograms of dandelion, 1 ~ 2 kilogram of purslane.The Chinese medicine preparation has good therapeutic effect to cardiovascular and cerebrovascular diseases such as coronary heart disease, cerebral infarctions；It takes simply, clinical application is safe and reliable.
Description
Technical field
The present invention relates to a kind of heart and brain to lead to Chinese medicine preparation.
Background technology
Existing much Chinese medicines for treating cardiovascular and cerebrovascular, especially treat the cardiovascular and cerebrovascular diseases such as coronary heart disease, cerebral infarction
Chinese medicine, common problem be in the recent period with the lesion remission rate of late result, germ clearance rate, prevention is efficient, faces
The effect of bed cure rate etc. is not ideal enough.Also there is adverse reaction after small number of patients medication.
Invention content
The present invention is intended to provide a kind of having good therapeutic effect and invariably to cardiovascular and cerebrovascular diseases such as coronary heart disease, cerebral infarctions
The Chinese medicine preparation of good reaction.
A kind of heart and brain provided by the invention lead to Chinese medicine preparation, it is characterised in that：It is made of the Chinese medicine of following weight proportion：
1~50 kilogram of Radix Codonopsis, 1~10 kilogram of hawthorn, 1~80 kilogram of ginseng, excessively crisp 1~50 kilogram of the pears of king, Radix Notoginseng 1~80
Kilogram, 1~10 kilogram of Jishan plate jujube, 1~40 kilogram of leech, 1~10 kilogram of Shanxi south Fructus Tritici Levis, 1~40 kilogram of amber, Radix Glycyrrhizae 1
~10 kilograms, 1~80 kilogram of pueraria lobata, 1~30 kilogram of dandelion, 1~10 kilogram of purslane.
Capsule, tablet, water-bindered pill agent can be made in the Chinese medicine preparation.
The preparation method of the traditional Chinese powder medicine capsule：It is ground into smalls after each taste Chinese medicine is mixed, glue is packed into after crossing 100 mesh sieve
Capsule, per the built-in 0.4 gram of traditional Chinese powder medicine of capsule.Capsule uses and does not destroy the proper methods such as the infrared ray, ultraviolet light or Co 60 of drug effect
Disinfection, to extend storage life.Capsule should avoid 40 degree Celsius or more high-temperature sterilizations.
The preparation method of the Chinese medicinal tablet：Smalls is ground into after each taste Chinese medicine is mixed, after crossing 100 mesh sieve, using Co 60 side
Method sterilized, by version in 2010《Pharmacopoeia of People's Republic of China one》Warp is added in the regulation of 1 rules of preparations annex 1D tablets of annex
The medical starch and medicinal powder of sterilization treatment, tabletting, sugar coating, per 0.4 gram of sheet weight.
The preparation method of the Chinese kmedicine bolus agent：Smalls is ground into after each taste Chinese medicine is mixed, after crossing 100 mesh sieve, using Co 60
Method sterilizes, and general water is ball, and every 10 ball weighs 1.2 grams.
Further, in the Chinese medicine preparation, the ginseng uses the sun-dried ginseng of Jilin production, Radix Notoginseng to be produced using Yunnan mountain of papers
Spring Radix Notoginseng, Radix Codonopsis uses the Jishan plate jujube of Yuncheng Jishan County production, Shanxi using the long RADIX CODONOPSIS PILOSULAE from Shanxi of China managed property, Jishan plate jujube
Southern Fructus Tritici Levis uses the Shanxi south Fructus Tritici Levis of Yuncheng production, the excessively crisp pears of king to be produced using the Yuncheng Yanhu District villages Wang Guo
The excessively crisp pears of king.
As a preferred embodiment, the specific formula of making double centner traditional Chinese powder medicine of the present invention is：10 kilograms of Radix Codonopsis, mountain
2 kilograms of short, bristly hair or beard, 16 kilograms of ginseng, excessively crisp 10 kilograms of the pears of king, 16 kilograms of Radix Notoginseng, 8 kilograms of leech, 16 kilograms of pueraria lobata, 8 kilograms of amber,
2 kilograms of Jishan plate jujube, 2 kilograms of Shanxi south Fructus Tritici Levis, 2 kilograms of Radix Glycyrrhizae, 6 kilograms of dandelion, 2 kilograms of purslane.
As a preferred embodiment, the Chinese medicine preparation is made of the Chinese medicine of following weight proportion：8 kilograms of Radix Codonopsis, hawthorn 1
Kilogram, 10 kilograms of ginseng, excessively crisp 8 kilograms of the pears of king, 10 kilograms of Radix Notoginseng, 6 kilograms of leech, 10 kilograms of pueraria lobata, 6 kilograms of amber, Jishan
1 kilogram of plate jujube, 1 kilogram of Shanxi south Fructus Tritici Levis, 1 kilogram of Radix Glycyrrhizae, 4 kilograms of dandelion, 1 kilogram of purslane.
As a preferred embodiment, the Chinese medicine preparation is made of the Chinese medicine of following weight proportion：7 kilograms of Radix Codonopsis, hawthorn 1
Kilogram, 9 kilograms of ginseng, excessively crisp 7 kilograms of the pears of king, 8 kilograms of Radix Notoginseng, 5 kilograms of leech, 8 kilograms of pueraria lobata, 5 kilograms of amber, Jishan plate jujube
1 kilogram, 1 kilogram of Shanxi south Fructus Tritici Levis, 1 kilogram of Radix Glycyrrhizae, 3 kilograms of dandelion, 1 kilogram of purslane.
The pharmacological property of Chinese medicine used in the present invention is as follows：
Radix Codonopsis, mild-natured, sweet in flavor, slightly sour, returns spleen, lung channel, function tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung.Modern pharmacology shows Radix Codonopsis
The blood flow of brain, lower limb and internal organ can be increased, cardiac output can be improved without increasing heart rate, blood pressure lowering.
Hawthorn, sour, sweet, tepor.Returns spleen, stomach, Liver Channel, food digesting stomach fortifying, scattered stasis have coronary artery dilator, diastole blood
The effect of pipe, blood fat-reducing blood pressure-decreasing cardiac stimulant.
Ginseng, flat property and sweet taste, slight bitter, returns spleen, lung, the heart channel of Hang-Shaoyin.Function is reinforced vital energy, and veins takes off admittedly reinforces the spleen to benefit the lung, peace of promoting the production of body fluid
God.Modern pharmacological research proves that ginseng has the function of anti-inflammatory, antiallergy, reconciles immunity of organisms and anti-heart failure effect.
The excessively crisp pears of king, cold nature is sweet in flavor, the thoughts of returning home, lung, liver, stomach, function clears away heart-fire, moistening lung, fall fire, promotes the production of body fluid, nourshing kidney, benefit
It is cloudy.The excessively crisp pears of king can slow down the scorching adverse reaction of ginseng；Pears seed contains lignin, is a kind of insoluble fiber, can be in intestines
Dissolving, formed as colloid film, can in intestines with cholesterol in conjunction with and exclude.Pear contain boron can prevent women's sclerotin dredge
Loose disease.When boron abundance, memory, attention, intelligence acuity can improve.The excessively crisp pears of king originate in the villages Wang Guo of Yuncheng Salt Lake area.By
Special in " small climate ", the excessively crisp pear fruit of king is big, and golden yellow color, thin skin, fine and tender taste is pure white, juice multi-flavor sweet tea, and shortcake is refreshing palatable, is
Top grade in pears.Soluble solid content is 12.8%, total acid content 0.09%, Gu acid ratio is 142.2, vitamin C 0.78%, and it is rich
There are many micronutrient elements such as calcium, iron, the phosphorus beneficial to human body, quench the thirst after food, relieve inflammation or internal heat, moistening lung, cough-relieving, resolving sputum, can play
It gets rid of illness the benefits of taking care of health.
Radix Notoginseng, warm-natured sweet in flavor, slight bitter, Return liver, stomach.Function dissipate stasis of blood hemostasis, detumescence ding-tong.Radix Notoginseng has good hemostasis
Effect and hematopoiesis function；Coronary microcirculation can be tightened and improved.
Jishan plate jujube, flat property and sweet taste enter spleen, stomach.Function strengthens the spleen and stomach, yin and blood nourishing, mental-tranquilization.Jishan plate jujube tree
Producing region is mainly in Tao Liang, the Yao Cun in Ji, Jishan County, Shanxi Province peak town, since small climate and geography are special, jujube delicate mouthfeel without slag,
Sugar content, vitamin and mineral jujube class highest, can be rated as " king in Chinese jujube ", transplant the history away from modern existing more than one thousand years, at
It is royal " tribute " for the successive dynasties.Plate date fruit thin skin, meat are thick, core is small, and meat is sweet, for oblateness, slightly shape with wide top and narrow bottom, therefore named plate
Jujube.Ripe fresh dates sugar content is up to 31.33%, acid content 0.1%, contains 499 milligrams of vitamin C in every 100 grams of fruits, also contains
The various trace elements such as potassium, sodium, calcium, manganese, zinc, iron, make it is dry after sugar content be up to 71.5%, various vitamins and amino acid contain
Amount is increased compared with fresh dates.There is special effect to treatment hepatitis, blood pressure lowering, doctor's carbuncle, brain tonic, anti-cancer and invigorating the spleen salubrity etc.
Fruit, is advanced tonic, and medical value is high.
Leech is aquatic annelid leech hirudo leech.The mild-natured salty hardship of taste, slightly poisonous, return liver warp.Function dissipating blood stasis with potent drugs,
Promoting menstruation.
Shanxi south Fructus Tritici Levis, cool in nature sweet in flavor, thoughts of returning home warp.Function QI invigorating removes hot hidroschesis, and reducing the asthenic fever is except vexed.
Amber is fossil sample substance of the resin through being transformed for many years under burial ground of ancient times coniferale plant.Sweet in flavor, property
It is flat, function tranquillizing the mind by relieving convulsion, dissipate stasis of blood hemostasis, stranguria treating and diuresis inducing, shade removing.
Radix Glycyrrhizae, flat property and sweet taste, the thoughts of returning home, lung, spleen, stomach.Function tonifying spleen, heat-clearing, emergency, moistening lung, many medicines of reconciliation.
In above-mentioned flavour of a drug, Shanxi south Fructus Tritici Levis has shared conditioning with Jishan plate jujube, Radix Glycyrrhizae and has slowed down coronary heart disease, Patients with Cerebral Infarction
Vexed palpitaition effect.
Pueraria lobata is the dry root of legume pueraria lobata, cool in nature sweet in flavor, pungent, returns spleen, stomach.Function expelling pathogenic factors from muscles and skin, bring down a fever, promote the production of body fluid,
Promoting eruption, Shengyang Zhixie.Modern pharmacological research proves its expansible coronary artery, improves heart function, improves Brain circlulation, there is the high blood for the treatment of
Press neck pain, fever and headache, hot dysentery, diabetes.
Dandelion, bitter cold in nature, sweet, Return liver, stomach.Function dispersing swelling and dissipating binds, dampness removing is treating stranguria, clearing heat and detoxicating.Modern pharmacology
Research has shown that its cardiac muscle that Anoxia can be protected to lose, and has hypoglycemic, effect for reducing fat.
Purslane, it is cold in nature sour, return large intestine；Liver Channel.Function clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body.There are decompression, diuresis.It is existing
Show that purslane has antibacterial action and certain cardiac effect for pharmacological research.
It is as follows that heart and brain of the present invention lead to situation of the Chinese medicine preparation for clinical：Using 168 hats of Chinese medicine preparation treatment of the present invention
Angina pectoris patient, and carry out clinical comparison sight with 56 control groups using " Fufang Danshen Pian+nitroglycerine tablets " treatment
It examines, 224 Treating Patients of Angina Pectoris are the secondary above person that breaks out weekly in total, according to randomized single blind trial with 3：1 ratio
It is divided into treatment group and control group.Treatment group takes orally Chinese medicine preparation of the present invention three times a day, 1.2 grams every time；Control group takes orally every time
0.5 milligram of 3+nitroglycerine tablets of Fufang Danshen Pian, three times a day；The course for the treatment of is one month.
Clinical observation angina pectoris attacks situation, the common symptons such as coronary heart disease uncomfortable in chest, palpitaition are done before treatment and at the end of the course for the treatment of
The inspections such as electrocardiogram, blood fat, blood glucose；The result shows that the effect of Chinese medicine preparation of the present invention is to coronary heart disease common sympton is effective 58
Example, effective 88, total effective rate 86.90%；And the total effective rate of control group is 42.86%.
Diagnosis basis：According to《People's Republic of China's traditional Chinese medicine industry standard --- Chinese medical disease Standardization of diagnosis and curative effect
（ZY/T001.1-94）》Regulation, with reference to " diagnosis basis of chest impediment and cardialgia ", chest impediment and cardialgia is by evil numbness heart network, and qi and blood is unsmooth
And cause uncomfortable in chest pained, very then chest pain radiating to the back, dyspnea with short breath must not crouch etc. be primary symptom heart vessel diseases.It is more common in coronary sclerosis
Property heart disease.Danzhong or pareordia are felt oppressed pain, very then the thorough left shoulder back of the body of pain, throat, the positions such as on the inside of the back of the body of upper left.Pectoralgia is in breaking-out
Property cannot persistently be alleviated.It is often accompanied by palpitation, spontaneous perspiration.Feeling of oppression and pain in the chest is alleviated for general several seconds to dozens of minutes.Severe patient aches
Acutely, limb huyashi-chuuka (cold chinese-style noodles) is white, and cyanosis of the lips and nails or arrhythmia cordis can die suddenly for pain.Often because overworking, depression is angry or drinks gluttony more, feels
It is induced by cold.Electrocardiogram etc. is looked into clarify a diagnosis.Myocardiase Examination, Dynamic Observation of Electrocardiograms are done when necessary.
Effect assessment：According to《People's Republic of China's traditional Chinese medicine industry standard --- Chinese medical disease Standardization of diagnosis and curative effect
（ZY/T001.1-94）》Regulation cure with reference to " the effect of chest impediment and cardialgia evaluates "：Symptom disappears, electrocardiogram and related experiment
Room checks normal.It improves：Symptom mitigates, and attack times are reduced, and the intermittent phase extends, and laboratory examination has improvement.It is not cured：Main disease
Shape and electrocardiogram are without change.
Heart and brain of the present invention, which lead to Chinese medicine preparation, answers age-based, weight, physical strength to determine dosage.When for treating, often take daily
Three times, it takes once within about every eight hours；Adult is 1.2~2.0 grams each taking dosage, and teenager is 1.2~1.6 grams.Each course for the treatment of
It is one month, will be generally relieved after a course for the treatment of or clinical symptoms substantially eliminate.When for preventing, often take daily
1.2 gram.Smoking And Drinking is avoided in medication period, avoids eating monosodium glutamate and animal's liver, marine product etc..
The applicable object of traditional Chinese powder medicine capsule of the present invention be coronary heart disease, cerebral infarction, cerebral arteriovenous malformation, artery of extremity thrombus or
The ischemics such as phlebitis, thrombotic diseases.After patient's use, recurrence rate is extremely low；Traditional Chinese powder medicine glue of the present invention has enhancing body
Immunity reduces blood fat, blood pressure and blood glucose, reduces blood viscosity, removing the work(that physiological and pathological waste matter accumulates wine unrest in vivo
Effect；It was verified that Chinese medicine preparation of the present invention can be obviously improved or eliminate the subjective symptoms of patient, anginal hair is substantially reduced
Make, developing into myocardial infarction to angina pectoris has apparent prevention effect, there is extremely strong prevention and treatment effect to cardiovascular and cerebrovascular diseases, long
Phase, which takes, to have no toxic side effect and obvious adverse reaction.
Model case 1：Mr. Wang, man, 69 years old, on March 1st, 2015 because：" ictal precordialgia 15 years aggravates 1
It " it is medical.There is precordialgia before 15 years after fatigue in patient, alleviated after 2-3 minutes through rest.Hereafter have when above-mentioned symptom
Breaking-out.Precordialgia breaking-out is frequent after fatigue before 1 day, rests and buccal nitroglycerine tablets symptom is not alleviated.Hyperlipidemia 15
Year, non-rule medication.There is hypertension history 15 years（Blood pressure is up to 200/110mmHg）, non-rule medication.Blood pressure when medical
170/100mmHg, 96 beats/min of heart rate breathe 20 beats/min, the low flat inversion of ECG ST section.Blood fat chemically examines TC6.9mmol/L,
TG2.9mmol/L.It gives anti-freezing, decompression, adjust effect unobvious after the treatments such as fat, add and lead to Chinese medicinal capsule with heart and brain of the present invention（Party
10 kilograms of ginseng, 2 kilograms of hawthorn, 16 kilograms of ginseng, excessively crisp 10 kilograms of the pears of king, 16 kilograms of Radix Notoginseng, 8 kilograms of leech, 16 kilograms of pueraria lobata,
8 kilograms of amber, 2 kilograms of Jishan plate jujube, 2 kilograms of Shanxi south Fructus Tritici Levis, 2 kilograms of Radix Glycyrrhizae, 6 kilograms of dandelion, 2 kilograms of purslane；It will
It is ground into smalls after above-mentioned each taste Chinese medicine mixing, capsule is packed into after crossing 100 mesh sieve, per the built-in 0.4 gram of traditional Chinese powder medicine of capsule）, often
Secondary dose is 2.0 grams, often takes daily 3 times, takes once for every eight hours.Curative effect is observed after one course for the treatment of：Blood pressure is 136/82mmHg,
76 beats/min of heart rate breathes 18 beats/min, and ECG ST section is normal.Blood fat chemically examines TC5.7mmol/L, TG1.7mmol/L..Before the heart
Area's pain relief, and do not reaccess in nearly three weeks.
Model case 2：Lee, female, 66 years old, on July 18th, 2014 because of " right side limb adynamia 7 days, aggravate 3 days " just
It examines.Patient gets up limb adynamia on the right side of chronognosis in the morning before 7 days, is not paid attention to；Felt that right side limb adynamia aggravates before 3 days, it is even
There is drinking-water to choke cough.There is diabetic history 8 years, non-rule medication.Hyperlipidemia 7 years, non-rule medication.Blood pressure 160/ when medical
90mmHg, 76 beats/min of heart rate breathe 20 beats/min, at once blood glucose 13.8mmol/L.Normal ECG.Brain CT shows basal ganglia region chamber
Gap cerebral infarction, blood fat chemically examine TC6.5mmol/L, TG2.3mmol/L.Giving improves brain blood supply, nourishing brain cell, antiplatelet
Aggregation, adjusts effect unobvious after the treatments such as fat, hypoglycemic at anti-freezing, adds and leads to ball with heart and brain of the present invention（10 kilograms of Radix Codonopsis, hawthorn 2,000
Gram, 16 kilograms of ginseng, excessively crisp 10 kilograms of the pears of king, 16 kilograms of Radix Notoginseng, 8 kilograms of leech, 16 kilograms of pueraria lobata, 8 kilograms of amber, Jishan plate
2 kilograms of jujube, 2 kilograms of Shanxi south Fructus Tritici Levis, 2 kilograms of Radix Glycyrrhizae, 6 kilograms of dandelion, 2 kilograms of purslane.Powder after each taste Chinese medicine is mixed
It is broken into smalls, smalls is ground into after each taste Chinese medicine is mixed, crosses the proper methods sterilizing such as Co 60 after 100 mesh sieve, general water is ball,
Every 10 ball weighs 1.2 grams.It is 1.2 grams each taking dosage, often takes daily 3 times, take once for every eight hours.Curative effect is observed after one course for the treatment of：Blood
Pressure is 130/80mmHg, and 66 beats/min of heart rate breathes 19 beats/min, blood TC5.5mmol/L, TG1.3mmol/L, blood glucose 6.1mmol/
L, myodynamia V grades of right side, activity is normal, and no drinking-water is choked cough.
Beneficial effects of the present invention：
Chinese medicine preparation prepared by the present invention has good therapeutic effect to cardiovascular and cerebrovascular diseases such as coronary heart disease, cerebral infarctions；It takes
Simply, clinical application is safe and reliable.
Specific implementation mode
It is further illustrated the present invention below by embodiment, but is not limited to following embodiment.
Embodiment 1：A kind of heart and brain lead to preparation and the application example of traditional Chinese powder medicine capsule
Below in conjunction with example, present invention is further described in detail：A kind of logical Chinese medicine preparation of heart and brain, by following parts by weight
Raw material composition：10 kilograms of Radix Codonopsis, 2 kilograms of hawthorn, 16 kilograms of ginseng, excessively crisp 10 kilograms of the pears of king, 16 kilograms of Radix Notoginseng, leech 8,000
Gram, 16 kilograms of pueraria lobata, 8 kilograms of amber, 2 kilograms of Jishan plate jujube, 2 kilograms of Shanxi south Fructus Tritici Levis, 2 kilograms of Radix Glycyrrhizae, 6 kilograms of dandelion,
2 kilograms of purslane.It is ground into smalls after each taste Chinese medicine is mixed, after crossing 100 mesh sieve, is disappeared using the infrared ray for not destroying drug effect
Poison is packed into capsule, per the built-in 0.4 gram of traditional Chinese powder medicine of capsule.
Patients with coronary heart disease 1967 is treated, is all made a definite diagnosis through brain CT or MRI.
Therapeutic scheme：It is 2.0 grams each taking dosage, often takes daily 3 times, take once for every eight hours.Each course for the treatment of is one month,
Curative effect is observed after continuously taking a course for the treatment of.
Criterion of therapeutical effect：It presses《Clinical neurologic deficit of stroke patients degree standards of grading》Formulation standard judges curative effect.
It cures：Clinical symptoms disappear, and linguistic function is restored；It is effective：For paralyzed limbs Myodynamia recovery to 2 grades or more, linguistic function is substantially extensive
It is multiple；Effectively：Paralyzed limbs muscular strength improves 1 grade, linguistic function progress；In vain：Symptom does not improve or improvement portion is apparent.
Treatment results：After a course for the treatment of, treatment results：796 people are cured, improve 1001 people, and more 170 people, always do not have
Efficiency 91.36%.
Embodiment 2：A kind of preparation of heart and brain water flowing ball and application example
Below in conjunction with example, present invention is further described in detail：A kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases, by
The raw material of following parts by weight forms：8 kilograms of Radix Codonopsis, 1 kilogram of hawthorn, 10 kilograms of ginseng, excessively crisp 8 kilograms of the pears of king, 10 kilograms of Radix Notoginseng,
6 kilograms of leech, 10 kilograms of pueraria lobata, 6 kilograms of amber, 1 kilogram of Jishan plate jujube, 1 kilogram of Shanxi south Fructus Tritici Levis, 1 kilogram of Radix Glycyrrhizae, dandelion
4 kilograms, 1 kilogram of purslane.It is ground into smalls after each taste Chinese medicine is mixed, is sterilized using Co 60 method after crossing 100 mesh sieve, water
General is ball, and every 10 ball weighs 1.2 grams.
Patients with cerebral infarction 307 is treated, is all made a definite diagnosis through brain CT or MRI.Wherein man 200, female 107；Age 44-78
Year；Acute stage 7, convalescence 300.
Therapeutic scheme：307 selected cases are given the logical ball of heart and brain of the present invention and are taken orally, and are 2.4 grams each taking dosage, often take daily
It 3 times, takes once for every eight hours, continuously takes a month as a treatment course, curative effect is observed after 2 courses for the treatment of are used in conjunction.
Criterion of therapeutical effect：It presses《Clinical neurologic deficit of stroke patients degree standards of grading》Formulation standard judges curative effect.
It cures：Clinical symptoms disappear, and linguistic function is restored；It is effective：For paralyzed limbs Myodynamia recovery to 2 grades or more, linguistic function is substantially extensive
It is multiple；Effectively：Paralyzed limbs muscular strength improves 1 grade, linguistic function progress；In vain：Symptom does not improve or improvement portion is apparent.
Treatment results：After treating 2 courses for the treatment of, 307 Patients with Cerebral Infarction healings 155, effective 100, effective 45, nothing
Effect 7, total effective rate 97.72%.Do not find that adverse drug reaction occurs for patient.
Embodiment 3：A kind of heart and brain lead to preparation and the application example of tablet
Below in conjunction with example, present invention is further described in detail：A kind of Chinese medicine preparation ginseng leech for treating cardiovascular and cerebrovascular diseases
Heart sermion tablet is made of the raw material of following parts by weight：7 kilograms of Radix Codonopsis, 1 kilogram of hawthorn, 9 kilograms of ginseng, excessively crisp 7 kilograms of the pears of king,
8 kilograms of Radix Notoginseng, 5 kilograms of leech, 8 kilograms of pueraria lobata, 5 kilograms of amber, 1 kilogram of Jishan plate jujube, 1 kilogram of Shanxi south Fructus Tritici Levis, Radix Glycyrrhizae 1,000
Gram, 3 kilograms of dandelion, 1 kilogram of purslane.It is ground into smalls after each taste Chinese medicine is mixed, Co 60 side is used after crossing 100 mesh sieve
Method sterilizes, and the medical starch and above-mentioned Chinese medicinal powder 0.39 that 0.01 gram of sterilized processing is added in requirement are made by national standard medicament tablet
Gram, tabletting, sugar coating, per 0.4 gram of sheet weight.
Therapeutic scheme：The heart sermion tablet that 197 selected patients with coronary heart disease give present invention treatment cardiovascular and cerebrovascular diseases is oral, often
Secondary dose is 1.6 grams（4）, often take daily 3 times, take once for every eight hours, continuously take a month as a treatment course, be used in conjunction 2
Curative effect is observed after the course for the treatment of.Equally use above-mentioned diagnosis basis, criterion of therapeutical effect, treatment results：106 people are cured, improve 73 people, not
More 18 people, total effective rate 90.86%.
Clinical observation shows the Chinese medicine preparation oral medication coronary heart disease using present invention treatment cardiovascular and cerebrovascular diseases, cerebral infarction
Etc. cardiovascular and cerebrovascular diseases, curative effect is apparent, and drug is easy to use, and patient is good using drug compliance, safety, and potency ratio is high.Animal is real
Test result：The present invention treats the pharmacodynamic experiment and acute toxicity testing result of the Chinese medicine preparation of cardiovascular and cerebrovascular diseases.
Pharmacodynamic experiment result：Chinese medicine preparation of the present invention is shown to the experiment of mouse transfer rod, resist oxygen lack and myocardial ischemia in rats
It is effective to improving cardiac function and alleviation myocardial ischemia；And it can restore or improve the ischemic electrocardiogram of animal.Acute toxicity testing
Experimental result：20 intragastric administration on mice are given respectively 14 days, no abnormality seen is anti-with 690 times of Chinese medicine preparations of the present invention of Coming-of-Age Day dosing
It answers, has no that overt toxicity reacts.
Claims (9)
1. a kind of heart and brain lead to Chinese medicine preparation, it is characterised in that：It is made of the Chinese medicine of following weight proportion：
7 ~ 10 kilograms of Radix Codonopsis, 1~2 kilogram of hawthorn, 9 ~ 16 kilograms of ginseng, excessively crisp 7 ~ 10 kilograms of the pears of king, 8 ~ 16 kilograms of Radix Notoginseng, Jishan
1 ~ 2 kilogram of plate jujube, 5 ~ 8 kilograms of leech, 1 ~ 2 kilogram of Shanxi south Fructus Tritici Levis, 5 ~ 8 kilograms of amber, 1~2 kilogram of Radix Glycyrrhizae, pueraria lobata 8 ~ 16,000
Gram, 3 ~ 6 kilograms of dandelion, 1 ~ 2 kilogram of purslane.
2. heart and brain according to claim 1 lead to Chinese medicine preparation, it is characterised in that：Capsule, piece can be made in the Chinese medicine preparation
Agent, water-bindered pill agent.
3. heart and brain according to claim 2 lead to Chinese medicine preparation, it is characterised in that：The preparation method of the capsule：By each taste Chinese medicine
It is ground into smalls after mixing, after crossing 100 mesh sieve, using not destroying the infrared ray of drug effect, the Disinfection Methods of ultraviolet light or Co 60,
To extend storage life；It is then charged into capsule, per the built-in 0.4 gram of traditional Chinese powder medicine of capsule.
4. heart and brain according to claim 2 lead to Chinese medicine preparation, it is characterised in that：The preparation method of the tablet：By each taste Chinese medicine
It is ground into smalls after mixing, after crossing 100 mesh sieve, is sterilized using Co 60 method, by version in 2010《Pharmacopoeia of People's Republic of China
One》The medical starch and medicinal powder of the sterilized processing of regulation addition of 1 rules of preparations annex 1D tablets of annex, tabletting, sugar coating,
Per 0.4 gram of sheet weight.
5. heart and brain according to claim 2 lead to Chinese medicine preparation, it is characterised in that：The preparation method of the water-bindered pill agent：It will be in each taste
It is ground into smalls after medicine mixing, after crossing 100 mesh sieve, is sterilized using Co 60 method, general water is ball, and every 10 ball weighs 1.2 grams.
6. heart and brain according to claim 1 lead to Chinese medicine preparation, it is characterised in that：The ginseng is sun-dried using Jilin production
Ginseng, Radix Notoginseng use the spring Radix Notoginseng of Yunnan mountain of papers production, Radix Codonopsis to use Yuncheng using the long RADIX CODONOPSIS PILOSULAE from Shanxi of China managed property, Jishan plate jujube
The Jishan plate jujube of Jishan County production, Shanxi south Fructus Tritici Levis use the Shanxi south Fructus Tritici Levis of Yuncheng production, the excessively crisp pears of king to use Shanxi
The excessively crisp pears of the king of province's Yuncheng Yanhu District villages Wang Guo production.
7. heart and brain according to claim 1 lead to Chinese medicine preparation, it is characterised in that：The Chinese medicine preparation is by following weight proportion
Chinese medicine be made：
10 kilograms of Radix Codonopsis, 2 kilograms of hawthorn, 16 kilograms of ginseng, excessively crisp 10 kilograms of the pears of king, 16 kilograms of Radix Notoginseng, 8 kilograms of leech, pueraria lobata
16 kilograms, 8 kilograms of amber, 2 kilograms of Jishan plate jujube, 2 kilograms of Shanxi south Fructus Tritici Levis, 2 kilograms of Radix Glycyrrhizae, 6 kilograms of dandelion, purslane 2
Kilogram.
8. heart and brain according to claim 1 lead to Chinese medicine preparation, it is characterised in that：The Chinese medicine preparation is by following weight proportion
Chinese medicine be made：
8 kilograms of Radix Codonopsis, 1 kilogram of hawthorn, 10 kilograms of ginseng, excessively crisp 8 kilograms of the pears of king, 10 kilograms of Radix Notoginseng, 6 kilograms of leech, pueraria lobata 10
Kilogram, 6 kilograms of amber, 1 kilogram of Jishan plate jujube, 1 kilogram of Shanxi south Fructus Tritici Levis, 1 kilogram of Radix Glycyrrhizae, 4 kilograms of dandelion, purslane 1,000
Gram.
9. heart and brain according to claim 1 lead to Chinese medicine preparation, it is characterised in that：The Chinese medicine preparation is by following weight proportion
Chinese medicine be made：
7 kilograms of Radix Codonopsis, 1 kilogram of hawthorn, 9 kilograms of ginseng, excessively crisp 7 kilograms of the pears of king, 8 kilograms of Radix Notoginseng, 5 kilograms of leech, pueraria lobata 8,000
Gram, 5 kilograms of amber, 1 kilogram of Jishan plate jujube, 1 kilogram of Shanxi south Fructus Tritici Levis, 1 kilogram of Radix Glycyrrhizae, 3 kilograms of dandelion, 1 kilogram of purslane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510491700.XA CN105031353B (en) | 2015-08-12 | 2015-08-12 | A kind of logical Chinese medicine preparation of heart and brain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510491700.XA CN105031353B (en) | 2015-08-12 | 2015-08-12 | A kind of logical Chinese medicine preparation of heart and brain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105031353A CN105031353A (en) | 2015-11-11 |
| CN105031353B true CN105031353B (en) | 2018-09-18 |
Family
ID=54438712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510491700.XA Expired - Fee Related CN105031353B (en) | 2015-08-12 | 2015-08-12 | A kind of logical Chinese medicine preparation of heart and brain |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105031353B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075884A (en) * | 1993-02-25 | 1993-09-08 | 张保仲 | A kind of novel therapeutic coronary heart disease electuary and preparation method thereof |
| CN1515274A (en) * | 2003-01-09 | 2004-07-28 | 河南省新乡联谊制药厂 | Medicine for curing coronary heart disease |
| CN103393749A (en) * | 2013-07-27 | 2013-11-20 | 李旭红 | Traditional Chinese medicine for preventing and treating ischemic cardiovascular and cerebrovascular diseases |
-
2015
- 2015-08-12 CN CN201510491700.XA patent/CN105031353B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075884A (en) * | 1993-02-25 | 1993-09-08 | 张保仲 | A kind of novel therapeutic coronary heart disease electuary and preparation method thereof |
| CN1515274A (en) * | 2003-01-09 | 2004-07-28 | 河南省新乡联谊制药厂 | Medicine for curing coronary heart disease |
| CN103393749A (en) * | 2013-07-27 | 2013-11-20 | 李旭红 | Traditional Chinese medicine for preventing and treating ischemic cardiovascular and cerebrovascular diseases |
Non-Patent Citations (2)
| Title |
|---|
| 参蛭心脑通胶囊对心肌梗死二级预防的临床观察;任德旺等;《环球中医药》;20130206;第6卷(第2期);第132页右栏第2段 * |
| 甘麦大枣汤治疗心血管疾病举隅;杨英;《福建中医药》;20000418;第31卷(第2期);第29页右栏倒数第1段，第20页左栏第1-2段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105031353A (en) | 2015-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105998297B (en) | A kind of Chinese medicine composition for relaxing bowel and preparation method thereof | |
| CN107213451A (en) | Improve probiotics fermention Chinese medicine preparation of microcirculation in human body obstacle and preparation method thereof | |
| Timba et al. | Health benefits and possible risks of turmeric, garlic and ginger: a short | |
| CN1306951C (en) | Medicine for curing qi deficiency induced thoracic obstruction (coronary heart disease) and technique for preparing the same | |
| CN103919008B (en) | There is health care congee of strengthening spleen, tonifying kidney function and preparation method thereof | |
| CN102671097A (en) | Oral traditional Chinese medicine composition for treating coronary heart disease | |
| CN103393749A (en) | Traditional Chinese medicine for preventing and treating ischemic cardiovascular and cerebrovascular diseases | |
| CN106490558A (en) | A kind of health-care honey and preparation method thereof | |
| CN109453317A (en) | A kind of anaesthetic and its preparation process for strengthening by means of tonics | |
| CN108478714A (en) | A kind of paediatrics self-closing disease rehabilitation auxiliary Chinese medicine composition | |
| CN1142785C (en) | Antifatigue capsule | |
| CN105031353B (en) | A kind of logical Chinese medicine preparation of heart and brain | |
| CN107125751A (en) | Tortoise powder, preparation method and applications | |
| CN104173745B (en) | A kind of anaesthetic of healthcare | |
| CN106822660A (en) | A kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease | |
| CN106038743A (en) | Blood pressure reducing electuary, and preparation method and application thereof | |
| CN101991829B (en) | Medicament for treating stomach illness | |
| CN112076305A (en) | A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation | |
| CN108126079A (en) | Plaster for treating constipation and preparation method thereof | |
| CN106822852A (en) | Treat pharmaceutical composition, its preparation technology and the purposes of coronary heart disease | |
| CN105214001B (en) | A kind of Chinese medicine composition for treating hypertensive patients coronary heart disease | |
| CN105343629B (en) | A kind of Chinese medicine composition and preparation method thereof for treating cardiac insufficiency | |
| CN1270733C (en) | Hunai Mushroom sclerotium used for treating diabotes and its preparation | |
| CN105031243B (en) | A kind of tune fat clearing liver Chinese medicine preparation | |
| CN114533838A (en) | Traditional Chinese medicine for strengthening body resistance and eliminating evil to treat early and middle lung cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180918 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |