CN103393749A - Traditional Chinese medicine for preventing and treating ischemic cardiovascular and cerebrovascular diseases - Google Patents
Traditional Chinese medicine for preventing and treating ischemic cardiovascular and cerebrovascular diseases Download PDFInfo
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- CN103393749A CN103393749A CN2013103189970A CN201310318997A CN103393749A CN 103393749 A CN103393749 A CN 103393749A CN 2013103189970 A CN2013103189970 A CN 2013103189970A CN 201310318997 A CN201310318997 A CN 201310318997A CN 103393749 A CN103393749 A CN 103393749A
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Abstract
The invention provides a traditional Chinese medicine for preventing and treating ischemic cardiovascular and cerebrovascular diseases for reducing onset of angina and preventing and treating ischemic cardiovascular and cerebrovascular diseases. The traditional Chinese medicine provided by the invention comprises the following components in parts by weight: 3.0-5.0 parts of ginseng, 1.0-3.0 parts of pseudo-ginseng, 1.0-3.0 parts of leech, 3.0-5.0 parts of the root of kudzu vine and 1.0-3.0 parts of amber. The traditional Chinese medicines are mixed and crushed to powder so as to prepare powder which is filled to capsules. The traditional Chinese medicine provided by the invention has good preventing and treating effect on ischemic cardiovascular and cerebrovascular diseases, and is simple to take and safe and reliable in clinical application.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the control ischemic cardio cerebrovascular diseases.
Background technology
Existing a lot of Chinese medicine for the control ischemic cardio cerebrovascular diseases, especially prevent and treat the Chinese medicine of hyperlipidemia, hypertension, diabetes, coronary heart disease, cerebral infarction, cerebral thrombosis and other thrombotic disease, ubiquitous problem is all not ideal enough in the effect of the aspects such as the pathological changes remission rate of recent and late result, virus sweep rate, control effective percentage, clinical cure rate.After also having the small number of patients medication, untoward reaction has appearred.
Summary of the invention
The object of the invention is exactly the deficiency that overcomes above-mentioned prior art, and a kind of Chinese medicine that reduces angina pectoris attacks, ischemic cerebrocardiac disease is had the control ischemic cardio cerebrovascular diseases of good prevention and therapeutic effect is provided.
The present invention according to the formula of unit of weight part meter is: Radix Ginseng 3.0-5.0 part, Radix Notoginseng 1.0-3.0 part, Hirudo 1.0-3.0 part, Radix Puerariae 3.0-5.0 part, succinum 1.0-3.0 part.
Panax's Araliaceae herbaceos perennial, the dry root and rhizome of Radix Ginseng, sweet in the mouth, little hardship, property is flat; Return spleen, lung, heart channel.Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, the easy lung of spleen reinforcing, promoting the production of body fluid and inducing sedation of the mind.Modern pharmacological research proof Radix Ginseng has effect and the anti-heart failure effect of antiinflammatory, antiallergic, conciliation immunity of organisms; Radix Notoginseng is the perennial root herbaceous plant, and sweet in the mouth, little hardship are warm in nature; Return liver, stomach warp.Effect: dissipating blood stasis hemostasis, subduing swelling and relieving pain.Radix Notoginseng has good hemostasia effect and hemopoietic function; Can tighten and improve Coronary microcirculation.Hirudo is the dry body of aquatic annelid Hirudo.Salty in the mouth is bitter, property is flat, slightly poisonous, returns Liver Channel.Has removing blood stasis, the effect of stimulating the menstrual flow.Succinum is the fossil sample material that is transformed for many years under burial ground of resin of coniferale plant in ancient times.Sweet in the mouth, property are put down, effect: tranquillizing the mind by relieving convulsion, dissipating blood stasis hemostasis, stranguria treating and diuresis inducing, improving eyesight removing nebula.Radix Puerariae is the dry root of legume pueraria lobata, and sweet in the mouth, suffering are cool in nature, returns spleen, stomach warp; Have expelling pathogenic factors from muscles, bring down a fever, promote the production of body fluid, the effect of rash, yang invigorating antidiarrheal.Modern pharmacological research proves that it has treatment hypertension neck pain, fever and headache, hematodiarrhoea, diabetes.
Radix Ginseng, Hirudo, Radix Notoginseng share and play imbalance of YIN and YANG in strong adjustment body, eliminate in body the turbid damp stasis of blood stagnant and have that invigorating blood circulation is stagnant, reduction blood fat, blood viscosity, blood pressure, blood glucose and antiinflammatory anti-allergic effects, therefore can jointly form main component of the present invention.Succinum, Radix Puerariae have share strengthens promoting qi circulation, resolving food retention, promoting blood circulation and hemostasis, especially can impel blood-activating and qi-promoting, promotes the excretion effect of waste matter dirt; Adjustment is dissolved in body and is constantly absorbed, causes the poisoning effects such as burden that repeat in excretion pathological product process.The medicine of respectively distinguishing the flavor of in the present invention is combined, have blood circulation promoting and blood stasis dispelling, QI invigorating, circulation of qi promoting, reduction blood fat, reduction blood viscosity, reduce blood pressure, reduce blood glucose, antiinflammatory, with removing physiology, pathology waste matter, accumulate in vivo and make random special efficacy, ischemic cerebrocardiac disease is had extremely strong prevention and therapeutic effect.
Described Radix Ginseng produces Radix Ginseng Rubra for well with Jilin; Described Radix Notoginseng produces with the Yunnan mountain of papers spring, Radix Notoginseng was for well; Hirudo produces wild pure natural black corpusculum dry product Hirudo for well with Jilin; Succinum with the Guangxi product for well; Radix Puerariae with the Anhui product for well.
It is as follows that Chinese medicine of the present invention is used for clinical situation: adopt the routine Treating Patients of Angina Pectoris for the treatment of by Chinese herbs 58 of the present invention, and with the 29 routine matched groups that adopt " FUFANG DANSHEN PIAN+nifedipine+sorbitrate " treatment, carry out the clinical contrast observation, 87 routine Treating Patients of Angina Pectoris are the above person of the secondary that shows effect weekly altogether, comprise outpatient service 32 examples, 55 examples of being in hospital; Be divided into treatment group and matched group according to randomized single blind trial with the ratio of 2:1.The oral Chinese medicine of the present invention for the treatment of group every day three times, each 2.2 grams; 10 milligrams of 10 milligrams+sorbitrates of matched group 4+nifedipine of each oral administered compound Radix Salviae Miltiorrhizae Tabellae, every day three times; Be one month the course for the treatment of.
Clinical observation angina pectoris attacks situation, the common symptons such as coronary heart disease is uncomfortable in chest, cardiopalmus, before treatment and have an electro-cardiogram while finishing the course for the treatment of, the inspections such as blood fat, blood glucose; Result shows, Chinese medicine of the present invention is produce effects 21 examples to the curative effect of coronary heart disease common sympton, effective 36 examples, total effective rate 98.3%; And the total effective rate of matched group is 42.8%.Chinese medicine of the present invention is produce effects 41 examples to curative effect to treat angina pectoris, improves 15 examples, total effective rate 96.6%; And the total effective rate of matched group is 75.7%.
Diagnosis basis: according to the regulation of " People's Republic of China's Chinese medicine industry standard---traditional Chinese medical science disease Standardization of diagnosis and curative effect (ZY/T001.1-94) ", with reference to " diagnosis basis of obstruction of qi in the chest and cardialgia ", obstruction of qi in the chest and cardialgia is by evil numbness heart network, QI and blood does not freely cause uncomfortable in chest pained, chest pain radiating to the back very, dyspnea with short breath must not crouch etc. and to be the heart vessel diseases of primary symptom.Be more common in coronary atherosclerotic heart disease.Danzhong or the pareordia pain of feeling oppressed, the very positions such as the thorough left shoulder back of the body of pain, throat, left upper arm inboard.Being ictal or lasting does not understand.Often with shortness of breath and palpitation, spontaneous perspiration, very failing to sleep due to dyspnea.Feeling of oppression and pain in the chest was alleviated to dozens of minutes in general several seconds.But the severe patient sharp ache, continue not understand, cold extremities due to sweating, and pale complexion, cyanosis of the lips and nails, palpitating speed, or the crisis such as arrhythmia, can die suddenly.Be more common in above middle age, often because overworking, depressed angry or polydipsia gluttony, impression is cold and bring out.Look into electrocardiogram, ambulatory electrocardiogram, exercise test etc. to clarify a diagnosis.Make in case of necessity Myocardiase Examination, Dynamic Observation of Electrocardiograms.
Effect assessment: according to the regulation of " People's Republic of China's Chinese medicine industry standard---traditional Chinese medical science disease Standardization of diagnosis and curative effect (ZY/T001.1-94) ", with reference to " efficacy evaluation of obstruction of qi in the chest and cardialgia ", cure: transference cure, electrocardiogram and relevant lab testing recover normal.Take a turn for the better: sx↓, attack times reduces, and the intermission extends, and lab testing is improved.Do not heal: cardinal symptom and electrocardiogram are without change.
Therapeutic Method: make 90 kilograms of the present invention and prevent and treat the Chinese powder medicine embodiment of ischemic cerebrocardiac disease: 30 kilograms of Radix Ginsengs, 10 kilograms of Radix Notoginseng, 10 kilograms of Hirudos, 10 kilograms of succinums, 30 kilograms of Radix Puerariaes.Above-mentioned each medicine material is mixed afterwards and pulverizes, excessively incapsulate the in-built 0.45 gram Chinese powder medicine of every capsule after 100 mesh sieves.Capsule adopts the proper methods such as infrared ray, ultraviolet or the Co 60 sterilization that does not destroy drug effect, to extend storage life.Capsule should be avoided the above high-temperature sterilization of 400C.
Chinese medicine of the present invention should be by age, body weight, physical strength are determined consumption.While being used for the treatment of, take every day three times, approximately every eight hours clothes once; The adult is the 2.0-3.0 gram each serving consumption, and teenager is the 1.0-1.5 gram.Be one month each course for the treatment of, generally all obvious alleviation can be arranged after the course for the treatment of, and perhaps clinical symptoms is eliminated substantially.While being used for prevention, take the 1-3 gram every day.Avoid and drink in medication period, diet monosodium glutamate and animal livers, marine product etc.When xerostomia appears in rear patient if take medicine, can drink and add the Radix Rehmanniae and take, or drink pears water is alleviated.
Therapeutic outcome: the common symptons such as clinical observation coronary heart disease is uncomfortable in chest, angina pectoris attacks situation, cardiopalmus, before treatment and have an electro-cardiogram while finishing the course for the treatment of, the inspections such as blood fat, blood glucose; Result shows, Chinese medicine of the present invention is produce effects 21 examples to the curative effect of coronary heart disease common sympton, effective 36 examples, total effective rate 98.3%; And the total effective rate of matched group is 42.8%.Chinese medicine of the present invention is produce effects 41 examples to curative effect to treat angina pectoris, improves 15 examples, total effective rate 96.6%; And the total effective rate of matched group is 75.7%.
The applicable object of Chinese medicine of the present invention is ischemic, the thrombotic disease such as coronary heart disease, cerebral infarction, cerebral arteriosclerosis, artery of extremity thrombosis or phlebitis.After the patient used, relapse rate was extremely low; Chinese medicine of the present invention has enhancing human body immunity power, reduces blood fat, blood pressure and blood glucose, reduction blood viscosity, remove the physiological and pathological waste matter and accumulate in vivo and make random effect; Facts have proved, Chinese medicine of the present invention can obviously improve or eliminate patient's subjective symptoms, significantly reduce anginal outbreak, angina pectoris is developed into myocardial infarction obvious preventive effect is arranged, ischemic cerebrocardiac disease is had extremely strong prevention and therapeutic effect, and long-term taking has no side effect and obvious adverse reaction.
Model case 1: Zhang, the man, 65 years old, medical in main cause on July 3rd, 2012 " ictal pareordia was felt oppressed uncomfortable 10 years, increased the weight of 2 days ".The patient pareordia discomfort of feeling oppressed occurred without obvious inducement before 10 years, without feeling sick, vomiting, dripping sweat and dying sense, and remission after rest 3-5 minute.After this above-mentioned symptom interruption is shown effect, and before 2 days, tired rear pareordia is felt oppressed, and discomfort is front shows effect frequently, and every day 2-3 time, buccal nitroglycerin and the rear remission of having a rest are incomplete.Hypertension history is arranged 9 years, blood pressure is up to 180/100mmHg, not rule medication.Hyperlipemia medical history 10 years, not rule medication.When medical, blood pressure is 158/102mmHg, and heart rate 82 times/minutes is breathed 21 times/minutes, cardiopulmonary abdomen no abnormality seen, and low flat inversion of ST section shown in Electrocardioscopy, lipid examination shows TC 6.1mmol/L, TG 2.0mmol/L.Give the treatments such as anticoagulant, blood pressure lowering, accent fat rear DeGrain, add with this Chinese powder medicine (30 kilograms of Radix Ginsengs, 10 kilograms of Radix Notoginseng, 10 kilograms of Hirudos, 10 kilograms of succinums, 30 kilograms of Radix Puerariaes.After being mixed, pulverizes above-mentioned each medicine material, incapsulate the in-built 0.45 gram Chinese powder medicine of every capsule after crossing 100 mesh sieves), be the 2.0-3.0 gram each serving consumption, take every day three times, once, observe the curative effect after the course for the treatment of, blood pressure are 136/88mmHg to approximately every eight hours clothes, heart rate 70 times/minutes, breathe 20 times/minutes, the ST segment base is shown in Electrocardioscopy, and this is normal, and lipid examination shows TC 5.7mmol/L, TG 1.6mmol/L.Pareordia is felt oppressed, and discomfort is obvious to be alleviated, and nearly three Zhou Laiwei reaccess.
Model case 2. Liu, the female, 63 years old, medical in JIUYUE in 2012 6 days main cause " in a unfavorable week of right side limb activity, increased the weight of 3 days ".The patient in before the week without obvious inducement morning the time conscious right side limb activity unfavorable, without feeling sick, vomiting, the diseases such as unconscious obstacle, incontinence of urination and defecation, paid attention to, before 3 days, conscious above-mentioned symptom increases the weight of, and occasionally has that drinking water chokes coughs.Diabetic history there are more than 10 years, take diet control blood glucose as main, not rule medication.Hyperlipemia medical history 6 years, not rule medication.When medical, blood pressure is 150/90mmHg, and heart rate 78 times/minutes is breathed 21 times/minutes, at once blood glucose 13.6mmol/L, cardiopulmonary abdomen no abnormality seen, Electrocardioscopy no abnormality seen, head CT shows the basal ganglia region lacunar infarction, and lipid examination shows TC 6.3mmol/L, TG 2.1mmol/L.Give antiplatelet aggregation, anticoagulant, improve cerebral blood supply, DeGrain after the treatments such as nourishing brain cell, accent fat, blood sugar lowering, add with this Chinese powder medicine (30 kilograms of Radix Ginsengs, 10 kilograms of Radix Notoginseng, 10 kilograms of Hirudos, 10 kilograms of succinums, 30 kilograms of Radix Puerariaes.After being mixed, pulverizes above-mentioned each medicine material, incapsulate the in-built 0.45 gram Chinese powder medicine of every capsule after crossing 100 mesh sieves), be the 2.0-3.0 gram each serving consumption, take every day three times, once, observe the curative effect after the course for the treatment of, blood pressure are 138/86mmHg to approximately every eight hours clothes, heart rate 68 times/minutes, breathe 20 times/minutes, lipid examination shows TC 5.6mmol/L, TG 1.5mmol/L, blood glucose 6.8mmol/L.The right side limb activity is unfavorable obviously to be alleviated, and without drinking-water, chokes expectoration now.
The specific embodiment
Embodiment 1: below in conjunction with embodiment, the present invention is described in further detail: a kind of Chinese medicine preparation that is used for the treatment of cardiovascular and cerebrovascular disease, made by the raw material of following weight portion:
The present invention according to the formula of unit of weight part meter is: 3.0 parts of Radix Ginsengs, 3.0 parts of Radix Notoginseng, 2.0 parts of Hirudos, 3.0 parts of Radix Puerariaes, 1.0 parts of succinums.Above-mentioned each medicine material is mixed afterwards and pulverizes, excessively incapsulate the in-built 0.45 gram Chinese powder medicine of every capsule after 100 mesh sieves.
Treatment patients with coronary heart disease 567 examples, the present embodiment medicine, above-mentioned diagnosis basis, criterion of therapeutical effect and the Therapeutic Method of same employing carries out clinical trial, after a course for the treatment of, therapeutic outcome: basic healing (clinical symptoms is eliminated substantially) 296 people, obviously alleviate 266 people, 5 people's DeGrains, effectively remission rate 99.1%.
Embodiment 2: below in conjunction with embodiment, the present invention is described in further detail: a kind of Chinese medicine preparation that is used for the treatment of cardiovascular and cerebrovascular disease, made by the raw material of following weight portion:
The present invention according to the formula of unit of weight part meter is: 3.0 parts of Radix Ginsengs, 3.0 parts of Radix Notoginseng, 2.0 parts of Hirudos, 1.0 parts of Radix Puerariaes, 2.0 parts of succinums.Above-mentioned each medicine material is mixed afterwards and pulverizes, excessively incapsulate the in-built 0.45 gram Chinese powder medicine of every capsule after 100 mesh sieves.
Treatment patients with coronary artery disease 107 examples, the present embodiment medicine, adopt above-mentioned diagnosis basis, criterion of therapeutical effect and Therapeutic Method to carry out clinical trial equally, after a course for the treatment of, therapeutic outcome: substantially cure 25 people, obviously alleviate 79 people, effectively remission rate 97.2%.Be used for the treatment of Transient ischemic attacks patient 58 examples, substantially cure 18 people, obviously alleviate 38 people, effectively remission rate 96.6%.
Embodiment 3: below in conjunction with embodiment, the present invention is described in further detail: a kind of Chinese medicine preparation that is used for the treatment of cardiovascular and cerebrovascular disease, raw material by following weight portion is made: the present invention according to the formula of unit of weight part meter is: 3.0 parts of Radix Ginsengs, 3.0 parts of Radix Notoginseng, 2.0 parts of Hirudos, 5.0 parts of Radix Puerariaes, 3.0 parts of succinums.Above-mentioned each medicine material is mixed afterwards and pulverizes, excessively incapsulate the in-built 0.45 gram Chinese powder medicine of every capsule after 100 mesh sieves.
Treatment patients with coronary artery disease 38 examples, the present embodiment medicine, adopt above-mentioned diagnosis basis, criterion of therapeutical effect and Therapeutic Method to carry out clinical trial equally, after a course for the treatment of, therapeutic outcome: substantially cure 6 people, obviously alleviate 29 people, effectively remission rate 92.1%.
Embodiment 4: below in conjunction with embodiment, the present invention is described in further detail: a kind of Chinese medicine preparation that is used for the treatment of cardiovascular and cerebrovascular disease, raw material by following weight portion is made: the present invention according to the formula of unit of weight part meter is: 5.0 parts of Radix Ginsengs, 3.0 parts of Radix Notoginseng, 1.0 parts of Hirudos, 3.0 parts of Radix Puerariaes, 2.0 parts of succinums.Above-mentioned each medicine material is mixed afterwards and pulverizes, excessively incapsulate the in-built 0.45 gram Chinese powder medicine of every capsule after 100 mesh sieves.
Treatment patients with coronary artery disease 36 examples, the present embodiment medicine, adopt above-mentioned diagnosis basis, criterion of therapeutical effect and Therapeutic Method to carry out clinical trial equally, after a course for the treatment of, therapeutic outcome: substantially cure 5 people, obviously alleviate 29 people, effectively remission rate 94.4%.
Embodiment 5: below in conjunction with embodiment, the present invention is described in further detail: a kind of Chinese medicine preparation that is used for the treatment of cardiovascular and cerebrovascular disease, raw material by following weight portion is made: the present invention according to the formula of unit of weight part meter is: 3.0 parts of Radix Ginsengs, 3.0 parts of Radix Notoginseng, 1.0 parts of Hirudos, 5.0 parts of Radix Puerariaes, 1.0 parts of succinums.Above-mentioned each medicine material is mixed afterwards and pulverizes, excessively incapsulate the in-built 0.45 gram Chinese powder medicine of every capsule after 100 mesh sieves.
Treatment patients with coronary artery disease 43 examples, the present embodiment medicine, adopt above-mentioned diagnosis basis, criterion of therapeutical effect and Therapeutic Method to carry out clinical trial equally, after a course for the treatment of, therapeutic outcome: substantially cure 9 people, obviously alleviate 32 people, effectively remission rate 95.3%.
Claims (4)
1. a Chinese medicine of preventing and treating ischemic cardio cerebrovascular diseases, is characterized in that according to the formula of unit of weight part meter being: 3.0～5.0 parts of Radix Ginsengs, 1.0～3.0 parts of Radix Notoginseng, 1.0～3.0 parts of Hirudos, 3.0～5.0 parts of Radix Puerariaes, 1.0～3.0 parts of succinums.
2. the Chinese medicine of control ischemic cardio cerebrovascular diseases as claimed in claim 1, be ground into powder after it is characterized in that each flavor Chinese medicine is mixed and make powder, incapsulates.
3. the Chinese medicine of control ischemic cardio cerebrovascular diseases as claimed in claim 1, is characterized in that described Radix Ginseng adopts Jilin to produce Radix Ginseng Rubra, the spring Radix Notoginseng that Radix Notoginseng adopts the Yunnan mountain of papers to produce.
4. the Chinese medicine of control ischemic cardio cerebrovascular diseases as claimed in claim 1, the concrete formula that it is characterized in that making 90 kilograms of Chinese powder medicines of the present invention is 30 kilograms of Radix Ginsengs, 10 kilograms of Radix Notoginseng, 10 kilograms of Hirudos, 10 kilograms of succinums, 30 kilograms of Radix Puerariaes; To be ground into powder after each flavor Chinese medicine mixing, excessively incapsulate the in-built 0.45 gram Chinese powder medicine of every capsule after 100 mesh sieves.
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| CN105031353A (en) * | 2015-08-12 | 2015-11-11 | 任德旺 | Vasodistal traditional Chinese medicine preparation |
| CN105456344A (en) * | 2016-01-07 | 2016-04-06 | 曹永芬 | Medicine composition for preventing and treating cardiovascnlar and cerebrovascular diseases |
| CN105878352A (en) * | 2016-05-30 | 2016-08-24 | 王政乾 | Drug for treating cerebrovascular disease and preparation method and application thereof |
| CN114432393A (en) * | 2022-02-22 | 2022-05-06 | 黑龙江省济仁药业有限公司 | Traditional Chinese medicine composition for treating coronary heart disease stable angina pectoris and preparation method and application thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105031353A (en) * | 2015-08-12 | 2015-11-11 | 任德旺 | Vasodistal traditional Chinese medicine preparation |
| CN105031353B (en) * | 2015-08-12 | 2018-09-18 | 任德旺 | A kind of logical Chinese medicine preparation of heart and brain |
| CN105456344A (en) * | 2016-01-07 | 2016-04-06 | 曹永芬 | Medicine composition for preventing and treating cardiovascnlar and cerebrovascular diseases |
| CN105878352A (en) * | 2016-05-30 | 2016-08-24 | 王政乾 | Drug for treating cerebrovascular disease and preparation method and application thereof |
| CN114432393A (en) * | 2022-02-22 | 2022-05-06 | 黑龙江省济仁药业有限公司 | Traditional Chinese medicine composition for treating coronary heart disease stable angina pectoris and preparation method and application thereof |
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Application publication date: 20131120 |