CN105031044A - Foot bathing solution for treating dermatophytosis - Google Patents
Foot bathing solution for treating dermatophytosis Download PDFInfo
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- CN105031044A CN105031044A CN201510497165.9A CN201510497165A CN105031044A CN 105031044 A CN105031044 A CN 105031044A CN 201510497165 A CN201510497165 A CN 201510497165A CN 105031044 A CN105031044 A CN 105031044A
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Abstract
The invention relates to foot bathing solution for treating dermatophytosis and belongs to the field of preventive medicine. The foot bathing solution consists of green tea, white alum and water, wherein the concentration of green tea is larger than or equal to 1.563mg/ml and the concentration of white alum is larger than or equal to 1.563mg/ml. The foot bathing solution is compound solution consisting of green tea and white alum, the minimum inhibitory concentrations of green tea and white alum are respectively 1.563mg/ml and 1.563mg/ml, and the compound combination has an obvious synergistic effect to the inhibitory effect of staphylococcus aureus, candida albicans, Trichophyton rubrum and aspergillus niger. According to toxicologic studies and acute toxicity test studies, the compound foot bathing solution is an actually nontoxic substance and has no irritation to skins.
Description
Technical field
The present invention relates to a kind of formula for the treatment of the foot-soaking liquid of beriberi, antibacterial for pedal skin, belong to preventive medicine field.
Background technology
Beriberi (also known as tinea pedis or tinea pedis) is the foot dermatosis caused by pathogenic fungus, has infectiousness.Beriberi is widely popular in the whole world, also quite high at the sickness rate of China's beriberi.Do not have sebaceous gland between the vola of people and toe, thus lack the fatty acid suppressing dermatophytes, physiological defense function is poor, and foot hyperhidrosis humidity or footgear stuffiness etc. all can bring out primary disease.Dermatophytes is usually through the publilc baths polluted, the floor of edge of pool, bath towel, public slippers, foot basin and infecting.In adult, the people of 70-80% has beriberi, and just weight is different.Be everlasting and increase the weight of summer, winter alleviates, and also has people not heal all the year round.
Folium Camelliae sinensis is the bud-leaf of plant of theaceae tea, and its medical value is with a long history.Record as far back as Shennong's Herbal, taking Folium Camelliae sinensis for a long time can " QI invigorating of calming the nerves, make light of one's life by commiting suicide resistance to old "; Along with deepening continuously of Folium Camelliae sinensis biochemical research, the pharmacological action of Folium Camelliae sinensis also more and more receives the concern of people, find at present Folium Camelliae sinensis have treatment diabetes, blood pressure lowering, antithrombotic and blood fat reducing, atherosclerosis, antibacterial, improve immunity and antitumor action.In numerous bacteriostatic test researchs of Folium Camelliae sinensis, be mainly the research that Folium Camelliae sinensis commute causes alimentary toxicosis pathogen to carry out, as Folium Camelliae sinensis can have inhibitory action in various degree to staphylococcus aureus, proteus vulgaris, escherichia coli, lactobacillus, bacillus botulinus, vibrio cholera, vibrio parahaemolyticus, bacillus pyocyaneus, shigella flexneri, Bacillus typhi.The present invention is at home and abroad first using the effective ingredient one of of Folium Camelliae sinensis as foot-soaking liquid.
Alumen, also known as Alumen, is a kind of crystal that aluminium potassium sulfate and water are formed.It has the effect of antibacterial, convergence, function of gallbladder promoting, anti-trichomonas vaginitis, in bacteriostasis, experiment shows, Alumen all has inhibitory action to staphylococcus aureus, Bacillus proteus, escherichia coli, bacillus pyocyaneus, anthrax bacillus, Fu Shi and Shiga bacillus, Bacillus typhi, Bacillus proteus, viridans streptococci, Hemolytic streptococcus, streptococcus pneumoniae, diphtheria corynebacterium, bacillus tuberculosis bovis, bordetella pertussis, meningitis bacillus, and Alumen and Folium Camelliae sinensis are share the foot-soaking liquid as treating beriberi by the present invention first.
Summary of the invention
The present invention is intended to develop a kind of foot-soaking liquid formula beriberi to effective therapeutical effect, minimal inhibitory concentration research and toxicologic study are carried out to it, thus develop one have effective bacteriostasis, working concentration low, without Acute Toxicity, without skin irritation, cheap, diffluent foot-soaking liquid formula.
Treat a foot-soaking liquid for beriberi, it is the solution be made up of green tea, Alumen and water, wherein, and the concentration >=1.563mg/ml of green tea, the concentration >=1.563mg/ml of Alumen.
Wherein, the mass ratio of green tea and Alumen is 1:0.9-1:1.1, and the mass ratio of green tea and Alumen is preferably 1:1.
Preferably, in foot-soaking liquid, the concentration of green tea is 4.689mg/ml, and the concentration of Alumen is 4.689mg/ml.
The preparation method of the foot-soaking liquid of above-mentioned treatment beriberi, comprises green tea to add in boiling water and soaks, be cooled to add Alumen during 50-60 DEG C and obtain, and namely this foot-soaking liquid adds Alumen by the infusion of green tea and obtains.
Green tea in this foot-soaking liquid and Alumen can be made into tea bag form, add after boiling water (hot water) soaks and obtain foot-soaking liquid.
Advantage of the present invention:
1, the minimal inhibitory concentration of this compound mixture is starkly lower than minimal inhibitory concentration when each composition is used alone.
2, this compound mixture is actual non-toxic type product, to no skin irritation.
Foot-soaking liquid of the present invention is the compound recipe solution be made up of green tea and Alumen, minimal inhibitory concentration is for containing green tea 1.563mg/ml, Alumen 1.563mg/ml, and the bacteriostasis of compound recipe combination to staphylococcus aureus, Candida albicans, trichophyton and Aspergillus niger has obvious potentiation.By carrying out toxicologic study and acute toxicity test research, this compound recipe foot-soaking liquid is actual nontoxic level material, to no skin irritation.
Accompanying drawing explanation
Fig. 1 is that Alumen is to staphylococcus aureus fungistatic effect.
Fig. 2 is that Alumen is to Candida albicans fungistatic effect.
Detailed description of the invention
1 experiment material
Green tea: originate from Qingdao; Yellow tea: originate from Hunan Dongting Lake; Folium Camelliae sinensis: originate from Quanzhou, Fujian; Black tea: originate from Wuyi Mountain, fujian; Postfermented tea: originate from yiyang, hunan.Alumen: Hubei Xing He chemical and medicine industry company limited.
Antibacterial: according to version " disinfection technology standard " regulation in 2002, the Bacteria Indicators of foot infection: staphylococcus aureus (Staphyloccocusaureus, S.aureusATCC6538), Candida albicans (MoniliaalbicanATCC10231) provides by Affiliated Hospital of Qingdao University microbiology teaching and research room's strain room, and Aspergillus niger (A.brasiliensisATCC16404) is provided by tech commerce and trade company limited of Qingdao HuaPu.Trichophyton (TrichophytonrubrumATCC), provides purchased from tech commerce and trade company limited of Qingdao HuaPu.
2 experimental techniques and result
2.1 Aqua Folium Camelliae sinensis immersion, alum solution bacteriostatic test method and result
Get above-mentioned various Folium Camelliae sinensis and add the distilled water 100ml boiled respectively, make tea liquor body in various Aqua Folium Camelliae sinensis immersion be respectively 100mg/ml, 50mg/ml, 25mg/ml, 12.5mg/ml, 6.25mg/ml, 3.125mg/ml6 concentration, Alumen distilled water is mixed with 100mg/ml, 50mg/ml, 25mg/ml, 12.5mg/ml, 6.25mg/ml, 3.125mg/ml, 1.5625mg/ml, 0.78125mg/ml8 dilution solution.Get the Aqua Folium Camelliae sinensis immersion and each 20 μ l of alum solution that prepare, drip on a circle China filter paper (d=5mm) of aseptic drying, simultaneously to drip the filter paper of 20 μ l sterile distilled waters as negative control, filter paper is dried for subsequent use.
Staphylococcus aureus, Candida albicans and Aspergillus niger being mixed with concentration is respectively 5 × 10
5cfu/ml ~ 5 × 10
6the test organisms liquid of cfu/ml.Dip bacterium liquid with sterile cotton swab, uniform application in nutrient agar and sabouraud culture medium surface, dry 5min under room temperature.Microbiological contamination flat board is placed with the filter paper prepared and negative control, is placed in 37 DEG C of calorstats and cultivates observed result after 16-18h.Record inhibition zone diameter with vernier caliper measurement, negative control group should produce without bacterial restrain, otherwise invalidate the test.Inhibition zone diameter is greater than 7mm person, for there being bacteriostasis, is less than or equal to 7mm person, and for without bacteriostasis, result is the meansigma methodss of 3 tests.
Trichophyton because of growth time longer, cannot bacterial restrain test be carried out.
Aqua Folium Camelliae sinensis immersion bacteriostatic test result:
The results are shown in Table 1, table 2, table 3.All have certain bacteriostasis by table 1, table 2, the visible green tea of table 3 result, yellow tea, Folium Camelliae sinensis, black tea, postfermented tea infusion to staphylococcus aureus, Candida albicans and Aspergillus niger, wherein the fungistatic effect of green tea infusion to three kinds of Bacteria Indicators is best.
The immersion of table 1 Aqua Folium Camelliae sinensis is to staphylococcus aureus bacterial restrain result of the test
The immersion of table 2 Aqua Folium Camelliae sinensis is to Candida albicans bacterial restrain result of the test
The immersion of table 3 Aqua Folium Camelliae sinensis is to Aspergillus niger bacterial restrain result of the test
Alumen bacteriostatic test result:
Table 4 alum solution bacterial restrain result of the test
As shown in Figure 1, for Alumen is to staphylococcus aureus fungistatic effect, wherein, 1-4 is respectively the fungistatic effect containing Alumen 25mg/ml, 12.5mg/ml, 6.25mg/ml, 3.125mg/ml.
As shown in Figure 2, for Alumen is to Candida albicans fungistatic effect, wherein, 1-4 is respectively the fungistatic effect containing Alumen 25mg/ml, 12.5mg/ml, 6.25mg/ml, 3.125mg/ml.
Bacterial restrain result from table 4: alum solution all has good fungistatic effect to staphylococcus aureus, Candida albicans and Aspergillus niger, Alumen dilution is still greater than 7 for during 3.125mg/ml to the inhibition zone diameter of staphylococcus aureus, Candida albicans.
2.2 Aqua Folium Camelliae sinensis immersion, alum solution minimal inhibitory concentration test method and result
Choose the good green tea of bacteriostasis, black tea infusion, alum solution carries out minimal inhibitory concentration test, 50mg/ml selected by black tea, 25mg/ml, 12.5mg/ml, 6.25mg/ml, 3.13mg/ml5 individual dilution factor, 25mg/ml selected by green tea, 12.5mg/ml, 6.25mg/ml, 3.13mg/ml4 individual dilution factor, alum solution selects 12.5mg/ml, 6.25mg/ml, 3.125mg/ml, 1.563mg/ml4 individual dilution factor, the Aqua Folium Camelliae sinensis immersion prepared and alum solution are distinguished mixed dissolution in double nutrient agar and sabouraud culture medium, mix homogeneously, treat that it solidifies for subsequent use, often organize preparation 3 plates.Preparation staphylococcus aureus, Candida albicans, Aspergillus niger and trichophyton bacteria suspension (5 × 10
5cfu/ml ~ 5 × 10
6cfu/ml), respectively at often organizing dibbling 2 μ l bacteria suspension in plate, mix as negative control group using sterilizing PBS and bactericidal nurishing agar culture medium and sabouraud culture medium.18h ~ 24h is cultivated, observed result in staphylococcus aureus, Candida albicans, Aspergillus niger 37 DEG C of incubators after inoculation.6d is cultivated, observed result in trichophyton 25 DEG C of incubators.
Minimal inhibitory concentration result of the test: the minimal inhibitory concentration of green tea to staphylococcus aureus, Candida albicans and trichophyton be 6.25mg/ml, be 12.5mg/ml to the minimal inhibitory concentration of Aspergillus niger; Black tea is 6.25mg/ml to the minimal inhibitory concentration of staphylococcus aureus, trichophyton, is 12.5mg/ml to the minimal inhibitory concentration of Candida albicans, is 25mg/ml to the minimal inhibitory concentration of Aspergillus niger; The minimal inhibitory concentration of Alumen to staphylococcus aureus and Candida albicans be 3.125mg/ml, be 6.25mg/ml to the minimal inhibitory concentration of Aspergillus niger, be 1.563mg/ml to the minimal inhibitory concentration of trichophyton.
The screening of 2.3 compound mixture formula
According to Aqua Folium Camelliae sinensis immersion minimal inhibitory concentration result of the test, choose the good green tea of fungistatic effect and Alumen adopts disc diffusion method to carry out bacteriostatic test to staphylococcus aureus, Candida albicans, Aspergillus niger and trichophyton respectively, to screen the proportioning of foot-soaking liquid compound mixture.The proportioning of each group of compound mixture is in table 5.Each group of compound mixture bacterial restrain result of the test is in table 6.
Table 5 is group compound mixture formula respectively
Table 6 compound mixture bacterial restrain result of the test
Note: trichophyton cannot carry out bacterial restrain test because of incubation time length
2.4 compound mixture solution minimal inhibitory concentration test method and results
According to compound mixture formulation screening test result, No. 1 and No. 4 formula are preferably to 4 kinds of test organisms fungistatic effects, according to the principle of the identical Selection experiment low concentration of fungistatic effect, by No. 4 formulated variable concentrations compound mixtures, minimal inhibitory concentration test is carried out to 4 kinds of test organismss, compound mixture formula is in table 7, and test method is with 2.2.Minimal inhibitory concentration result of the test is in table 8.
Table 7 each group of formula mixture solution
Table 8 compound mixture is to the minimal inhibitory concentration of 3 kinds of test organismss
From table 8 result, obviously strengthen the bacteriostasis of staphylococcus aureus, Candida albicans, Aspergillus niger and trichophyton when green tea and Alumen conbined usage, visible green tea and Alumen conbined usage have obvious potentiation.For ensureing there is bacteriostasis to 4 kinds of Bacteria Indicators, the minimal inhibitory concentration of this compound mixture is for containing green tea 1.563mg/ml, Alumen 1.563mg/ml.
2.5 toxicology test
2.5.1 acute oral toxicity test
Select body weight 18-22g mice 20, male and female half and half, sub-cage rearing.Raise 7d in advance before test, overnight fasting, not water restriction before test, adopt once test method to greatest extent, a given low 5000mg/ (kgbw), gives mice by per os gavage mode by the above-mentioned compound mixture prepared.After every mouse weights, divide 2 gavages by each 30mL/ (kgbw) dosage, midfeather 12h.Observe in 14d after contamination animal poisoning manifestations, with or without dead, dead quantity in time between.
Acute oral toxicity test result:
In 14d, laboratory animal is all without any poisoning manifestations, nothing death.According to acute oral toxicity test criterion, this compound Chinese herb mixture LD can be judged
50being greater than 5000mg/kg body weight, is actual non-toxic type material.
2.5.2 Skin Irritation Test
Because this compound mixture is applicable to foot repeatedly soaking therapy beriberi, therefore adopt repeatedly intact skin irritant test method, select that 3 skin is intact, heavily about 3kg New Zealand white rabbit, 24h before test, slough the hair of each about 3cm × 3cm in its spinal column both sides, back, minimal inhibitory concentration 3 times of compound mixture solution 0.5ml drip on 2 layers of sterile gauze of 2.5cm × 2.5cm by next day, are applied to skin of unhairing surface, side, use non-stimulated immobilization with adhesive tape, opposite side drips with distilled water 0.5ml and compares on sterile gauze.Thing of applying ointment or plaster is removed, with sterile distilled water cleaning removing residue after 4h.Smear every day once, smear 14d continuously.Observe local skin reaction respectively at 24h after removal tested material, carry out irritant reaction scoring.
Skin Irritation Test result:
Respectively at observing the local skin reaction of test rabbits spinal column both sides after 24h, observed result is for test rabbit both sides skin is all without red and swollen and erythema, and scoring is 0, and skin irritation strength grading is nonirritant rank.
Embody rule embodiment:
Preparation foot-soaking liquid: be cooled to add Alumen during 50-60 DEG C by green tea through boiling water immersion and obtain, practical application concentration is 3 times of minimal inhibitory concentration, and namely green tea is 4.689mg/ml, Alumen 4.689mg/ml.
1, beam ××, female, 65 years old, people from Qingdao City, the grain of rice large vesicle in many places between patient's both feet toe, and itch with play.Apply this foot-soaking liquid foot bath every day 20-30 minute, after 20 days, symptom disappears completely.
2, king ×, man, 40 years old, people from Jimo City, have many places to peel between patient's both feet toe, there was rotten to the corn face local, and apply this compound recipe foot-soaking liquid after 30 days, symptom disappears completely.
3, Shandong ××, female, 52 years old, people from Qingdao City, suffer from more than 10 years of beriberi, have erosion between toe, sole has red point, vesicle, very itches at ordinary times, continuously uses this compound recipe foot-soaking liquid 30 days, every day foot bath 20-30 minute, sole is as before smooth.
4, Guo's ××, man, 68 years old, people from Qingdao City, suffer from more than 10 years of beriberi, have decortication between double-legged toe, sole has small red dot, continuously uses this compound recipe foot-soaking liquid 20 days, every day foot bath 20-30 minute, symptom disappears completely.
5, open ××, man, 28 years old, people from Qingdao City, had the large vesicle of the many places grain of rice between double-legged toe, sole has red point, applies this compound recipe foot-soaking liquid after 20 days, transference cure.
Beriberi is one of disease that foot sickness rate is the highest, the foot-soaking liquid that the present invention is is effective ingredient with Folium Camelliae sinensis and Alumen.In green tea, yellow tea, black tea, postfermented tea, several Folium Camelliae sinensis of Folium Camelliae sinensis, best with the fungistatic effect of green tea, minimal inhibitory concentration is staphylococcus aureus, Candida albicans, trichophyton 6.25mg/ml, Aspergillus niger 12.5mg/ml; The minimal inhibitory concentration of Alumen to staphylococcus aureus, Candida albicans is 3.125mg/ml, is 6.25mg/ml to the minimal inhibitory concentration of Aspergillus niger, is 1.563mg/ml to the minimal inhibitory concentration of trichophyton.This foot-soaking liquid is the compound recipe solution be made up of green tea and Alumen, minimal inhibitory concentration is for containing green tea 1.563mg/ml, Alumen 1.563mg/ml, the mass ratio of green tea and Alumen can be 1:(0.9-1.1), the bacteriostasis of compound recipe combination to staphylococcus aureus, Candida albicans, trichophyton and Aspergillus niger has obvious potentiation.Carried out toxicologic study further, through acute toxicity test research, this compound recipe foot-soaking liquid is actual nontoxic level material, to no skin irritation.
Claims (6)
1. treat a foot-soaking liquid for beriberi, it is characterized in that: be made up of green tea, Alumen and water, the concentration >=1.563mg/ml of green tea, the concentration >=1.563mg/ml of Alumen.
2. the foot-soaking liquid for the treatment of beriberi according to claim 1, is characterized in that: described green tea and the mass ratio of Alumen are 1:0.9-1:1.1.
3. the foot-soaking liquid for the treatment of beriberi according to claim 2, is characterized in that: described green tea and the mass ratio of Alumen are 1:1.
4. the foot-soaking liquid for the treatment of beriberi according to claim 3, is characterized in that: the concentration of described green tea is 4.689mg/ml, and the concentration of described Alumen is 4.689mg/ml.
5. the foot-soaking liquid for the treatment of beriberi according to claim 1, is characterized in that: described green tea and Alumen make tea bag.
6. the preparation method of the foot-soaking liquid for the treatment of beriberi according to claim 1, comprises the steps: green tea to add in boiling water to soak, and is cooled to add Alumen during 50-60 DEG C, obtains foot-soaking liquid.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732200A (en) * | 2008-11-17 | 2010-06-16 | 张舜平 | Foot washing powder |
| CN102415975A (en) * | 2011-12-12 | 2012-04-18 | 大连创达技术交易市场有限公司 | Chinese medicine deodorizing foot bath salt |
| CN103446343A (en) * | 2013-09-13 | 2013-12-18 | 吕培卖 | External pharmaceutical composition for treating dermatophytosis and foot ordor |
| CN103550405A (en) * | 2013-10-29 | 2014-02-05 | 湖州康复医院 | Composition for treating foot odor |
| CN103656425A (en) * | 2013-12-06 | 2014-03-26 | 山东中大药业有限公司 | Traditional Chinese medicine composition for treating foot odor and preparation method thereof |
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2015
- 2015-08-13 CN CN201510497165.9A patent/CN105031044A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732200A (en) * | 2008-11-17 | 2010-06-16 | 张舜平 | Foot washing powder |
| CN102415975A (en) * | 2011-12-12 | 2012-04-18 | 大连创达技术交易市场有限公司 | Chinese medicine deodorizing foot bath salt |
| CN103446343A (en) * | 2013-09-13 | 2013-12-18 | 吕培卖 | External pharmaceutical composition for treating dermatophytosis and foot ordor |
| CN103550405A (en) * | 2013-10-29 | 2014-02-05 | 湖州康复医院 | Composition for treating foot odor |
| CN103656425A (en) * | 2013-12-06 | 2014-03-26 | 山东中大药业有限公司 | Traditional Chinese medicine composition for treating foot odor and preparation method thereof |
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