CN107802664A - A kind of children's antiseptic composition and preparation method thereof - Google Patents
A kind of children's antiseptic composition and preparation method thereof Download PDFInfo
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- CN107802664A CN107802664A CN201711309503.7A CN201711309503A CN107802664A CN 107802664 A CN107802664 A CN 107802664A CN 201711309503 A CN201711309503 A CN 201711309503A CN 107802664 A CN107802664 A CN 107802664A
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- children
- antiseptic composition
- root oil
- borneol
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- 239000000203 mixture Substances 0.000 title claims abstract description 23
- 230000002421 anti-septic effect Effects 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000014220 Rhus chinensis Nutrition 0.000 claims abstract description 14
- 240000003152 Rhus chinensis Species 0.000 claims abstract description 14
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 12
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940116229 borneol Drugs 0.000 claims abstract description 12
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 12
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 12
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 10
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 10
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000011187 glycerol Nutrition 0.000 claims abstract description 10
- 229940041616 menthol Drugs 0.000 claims abstract description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 10
- 229940070384 ventolin Drugs 0.000 claims abstract description 10
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 9
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 9
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 9
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000008117 stearic acid Substances 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- -1 poly (hexamethylene) hydrochloride Polymers 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims description 10
- 239000003883 ointment base Substances 0.000 claims description 10
- 239000008213 purified water Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 229960000789 guanidine hydrochloride Drugs 0.000 claims description 3
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- RZYKUPXRYIOEME-UHFFFAOYSA-N CCCCCCCCCCCC[S] Chemical compound CCCCCCCCCCCC[S] RZYKUPXRYIOEME-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 240000002853 Nelumbo nucifera Species 0.000 claims 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims 1
- 125000005456 glyceride group Chemical group 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 239000003814 drug Substances 0.000 abstract description 6
- 239000000645 desinfectant Substances 0.000 abstract description 5
- 206010053615 Thermal burn Diseases 0.000 abstract description 4
- 206010014198 Eczema infantile Diseases 0.000 abstract description 2
- 201000008937 atopic dermatitis Diseases 0.000 abstract description 2
- 239000002674 ointment Substances 0.000 abstract description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 208000010201 Exanthema Diseases 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- RSWGJHLUYNHPMX-UHFFFAOYSA-N 1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid Chemical compound C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- JCVJEEJXXIFPCD-UHFFFAOYSA-N 1-methylideneguanidine;hydrochloride Chemical compound Cl.NC(=N)N=C JCVJEEJXXIFPCD-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 235000004256 Buglossoides arvense Nutrition 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 241000118841 Lithospermum incisum Species 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000013064 chemical raw material Substances 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940021414 skin shield Drugs 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Insects & Arthropods (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of children's antiseptic composition, count in parts by weight, raw material includes following components：2 ~ 8 parts of glycerin monostearate, 8 ~ 15 parts of stearic acid, 8 ~ 15 parts of atoleine, 2 ~ 8 parts of medical ventolin, 1 ~ 5 part of glycerine, 1 ~ 5 part of lauryl sodium sulfate, 0.1 ~ 0.6 part of poly (hexamethylene) hydrochloride, 0.4 ~ 1.0 part of polyvinylpyrrolidone, 8 ~ 15 parts of Groomwell root oil, 0.1 ~ 0.2 part of menthol, 0.1 ~ 0.2 part of borneol, 3.0 ~ 6.0 parts of nutgall extractive.The present invention gives full play to the advantages of Chinese medicine, by the reasonably combined of disinfectant raw material and Chinese medicine, has given full play to the characteristic of Groomwell root oil, ointment is made using oil-in-water principle, it is not only easy to use, Groomwell root oil curative effect is also enhanced, has the effect of obvious to infantile eczema, burn, scald.
Description
Technical field
The present invention relates to disinfectant field, and in particular to a kind of children's antiseptic composition and preparation method thereof.
Background technology
Used skin disinfectant for external use is mainly directly dissolved with chemical raw material in the market is formulated, technique letter
Single, effect is single, and can only play has killing and inhibitory action to various microorganisms；It is wet that one kind that my company is developed is used for children
Rash, burn, scald sterilization add Chinese medical extract Groomwell root oil, nutgall extractive, peppermint on the basis of traditional disinfection agent
Brain, borneol, used disinfectant has been played feature possessed by Chinese medicine, enhance antibacterial, antibacterial curative effect, it is wet to children
Rash, burn, scald have certain adjuvant treatment effect.
The content of the invention
The present invention proposes a kind of children's antiseptic composition and preparation method thereof, for solving to ask existing for prior art
Topic.
To achieve these goals, the technical solution adopted in the present invention is：
A kind of children's antiseptic composition, is counted in parts by weight, and raw material includes following components：It is 2 ~ 8 parts of glycerin monostearate, hard
8 ~ 15 parts of resin acid, 8 ~ 15 parts of atoleine, 2 ~ 8 parts of medical ventolin, 1 ~ 5 part of glycerine, 1 ~ 5 part of lauryl sodium sulfate, poly- six
0.1 ~ 0.6 part of methylene guanidine hydrochloride, 0.4 ~ 1.0 part of polyvinylpyrrolidone, 8 ~ 15 parts of Groomwell root oil, 0.1 ~ 0.2 part of menthol,
0.1 ~ 0.2 part of borneol, 3.0 ~ 6.0 parts of nutgall extractive.
Further, count in parts by weight, raw material includes following components：5 ~ 8 parts of glycerin monostearate, stearic acid 10 ~
12 parts, 11 ~ 12 parts of atoleine, 3 ~ 6 parts of medical ventolin, 2 ~ 4 parts of glycerine, 3 ~ 5 parts of lauryl sodium sulfate, polyhexamethylene
0.2 ~ 0.5 part of guanidine hydrochloride, 0.4 ~ 0.6 part of polyvinylpyrrolidone, 10 ~ 11 parts of Groomwell root oil, 0.1 ~ 0.2 part of menthol, borneol
0.1 ~ 0.2 part, 3.0 ~ 4.5 parts of nutgall extractive.
Further, the polyvinylpyrrolidonemolecules molecules amount is 20 ~ 300,000.
Further, the nutgall extractive is gallic water extract and/or alcohol extract.
Further, the dosage form of described composition is paste.
Present invention also offers a kind of preparation method of children's antiseptic composition, comprise the following steps：
1）Glycerin monostearate, stearic acid, medical ventolin, atoleine heating mixing are weighed in proportion, obtain mixed liquor A；
2）Separately take purified water to heat, add glycerine, lauryl sodium sulfate, polyvinylpyrrolidone, poly- six methylene weighed
Base guanidine hydrochloride, obtains mixed liquid B；
3）Mixed liquid B is added into mixed liquor A, it is stirring while adding, obtain ointment bases；
4）The Groomwell root oil weighed, nutgall extractive, borneol, menthol are added to ointment bases, stirred, packing, both.
Further, the step 1）Middle heating-up temperature is 85-90 DEG C.
Beneficial effect of the present invention：
First, the present invention gives full play to the advantages of Chinese medicine, by the reasonably combined of disinfectant raw material and Chinese medicine, has given full play to Asian puccoon
Oil characteristic, ointment is made using oil-in-water principle, it is not only easy to use, also enhance Groomwell root oil curative effect, to infantile eczema,
Burn, scald have the effect of obvious.
2nd, the use of nutgall extractive enhances antibacterial, antibacterial, antiinflammation, and effective guarantor is played for damaged skin
Shield acts on.
3rd, the addition of menthol, borneol, the characteristic of Chinese medicine is given full play to, prevents biting for mosquito from effectively prevent sterilization
Agent effect secondary pollution.
4th, the addition of surfactant can be such that Chinese medical extract composition fully discharges, and reach and preferably sterilize, be antibacterial, killing
Bacterium effect.
5th, the characteristics of this product is made the convenient storage of cream and used, and preparation technology meets large-scale production.
Embodiment
The present invention is described in further detail below by specific embodiment.
Embodiment 1
A kind of preparation method of children's antiseptic composition, comprises the following steps：
1）2 parts of glycerin monostearate, 8 parts of stearic acid, 8 parts of atoleine, 2 parts of medical ventolin is weighed in proportion at 85 DEG C to add
Hot mixing, obtain mixed liquor A；
2）It is another to take purified water to be heated to 85 DEG C, add 1 part of glycerine, 1 part of lauryl sodium sulfate, poly (hexamethylene) hydrochloride
0.1 part, 0.4 part of polyvinylpyrrolidone, obtain mixed liquid B；
3）Mixed liquid B is added into mixed liquor A, maintains the temperature at 85 DEG C, it is stirring while adding, obtain ointment bases；
4）8 ~ 15 parts of Groomwell root oil, 0.1 part of menthol, 0.1 part of borneol, 3.0 parts of nutgall extractive are added to ointment bases, stirred
Mix, dispense, both.
Embodiment 2
A kind of preparation method of children's antiseptic composition, comprises the following steps：
1）6 parts of glycerin monostearate, 11 parts of stearic acid, 11 parts of atoleine, 5 parts of medical ventolin are weighed in proportion in 85-
90 DEG C of heating mixing, obtain mixed liquor A；
2）It is another to take purified water to be heated to 85 DEG C, add 3 parts of glycerine, 4 parts of lauryl sodium sulfate, poly (hexamethylene) hydrochloride
0.4 part, 0.5 part of polyvinylpyrrolidone, obtain mixed liquid B；
3）Mixed liquid B is added into mixed liquor A, maintains the temperature at 85-90 DEG C, it is stirring while adding, obtain ointment bases；
4）11 parts of Groomwell root oil, 0.2 part of menthol, 0.2 part of borneol, 3.5 parts of nutgall extractive are added to ointment bases, stirred
Mix, dispense, both.
Embodiment 3
A kind of preparation method of children's antiseptic composition, comprises the following steps：
1）8 parts of glycerin monostearate, 15 parts of stearic acid, 15 parts of atoleine, 8 parts of medical ventolin are weighed in proportion at 90 DEG C
Heating mixing, obtains mixed liquor A；
2）It is another to take purified water to be heated to 85 DEG C, add 5 parts of glycerine, 5 parts of lauryl sodium sulfate, poly (hexamethylene) hydrochloride
0.6 part, 1.0 parts of polyvinylpyrrolidone, obtain mixed liquid B；
3）Mixed liquid B is added into mixed liquor A, maintains the temperature at 90 DEG C, it is stirring while adding, obtain ointment bases；
4）15 parts of Groomwell root oil, 0.2 part of menthol, 0.2 part of borneol, 6.0 parts of nutgall extractive are added to ointment bases, stirred
Mix, dispense, both.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, there can be various modifications and variations in the spirit and principles in the present invention, these equivalent modifications or replacement etc.,
It is all contained within protection scope of the present invention.
Claims (7)
1. a kind of children's antiseptic composition, it is characterised in that count in parts by weight, raw material includes following components：Monostearate
2 ~ 8 parts of glyceride, 8 ~ 15 parts of stearic acid, 8 ~ 15 parts of atoleine, 2 ~ 8 parts of medical ventolin, 1 ~ 5 part of glycerine, dodecyl sulphur
It is sour 1 ~ 5 part of sodium, 0.1 ~ 0.6 part of poly (hexamethylene) hydrochloride, 0.4 ~ 1.0 part of polyvinylpyrrolidone, 8 ~ 15 parts of Groomwell root oil, thin
0.1 ~ 0.2 part of lotus brain, 0.1 ~ 0.2 part of borneol, 3.0 ~ 6.0 parts of nutgall extractive.
2. children's antiseptic composition according to claim 1, it is characterised in that count in parts by weight, raw material includes following
Component：5 ~ 8 parts of glycerin monostearate, 10 ~ 12 parts of stearic acid, 11 ~ 12 parts of atoleine, 3 ~ 6 parts of medical ventolin, glycerine 2 ~
4 parts, 3 ~ 5 parts of lauryl sodium sulfate, 0.2 ~ 0.5 part of poly (hexamethylene) hydrochloride, 0.4 ~ 0.6 part of polyvinylpyrrolidone,
10 ~ 11 parts of Groomwell root oil, 0.1 ~ 0.2 part of menthol, 0.1 ~ 0.2 part of borneol, 3.0 ~ 4.5 parts of nutgall extractive.
3. children's antiseptic composition according to claim 1, it is characterised in that：The polyvinylpyrrolidonemolecules molecules amount exists
20 ~ 300,000.
4. children's antiseptic composition according to claim 1, it is characterised in that：The nutgall extractive is gallic
Water extract and/or alcohol extract.
5. children's antiseptic composition according to claim 1, it is characterised in that：The dosage form of described composition is cream
Agent.
6. the preparation method of children's antiseptic composition as described in any according to claim 1-5, it is characterised in that including following
Step：
1）Glycerin monostearate, stearic acid, medical ventolin, atoleine heating mixing are weighed in proportion, obtain mixed liquor A；
2）Separately take purified water to heat, add glycerine, lauryl sodium sulfate, polyvinylpyrrolidone, poly- six methylene weighed
Base guanidine hydrochloride, obtains mixed liquid B；
3）Mixed liquid B is added into mixed liquor A, it is stirring while adding, obtain ointment bases；
4）The Groomwell root oil weighed, nutgall extractive, borneol, menthol are added to ointment bases, stirred, packing, both.
7. children's antiseptic composition according to claim 6, it is characterised in that：The step 1）Middle heating-up temperature is 85-
90℃。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711309503.7A CN107802664A (en) | 2017-12-11 | 2017-12-11 | A kind of children's antiseptic composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711309503.7A CN107802664A (en) | 2017-12-11 | 2017-12-11 | A kind of children's antiseptic composition and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107802664A true CN107802664A (en) | 2018-03-16 |
Family
ID=61588972
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711309503.7A Withdrawn CN107802664A (en) | 2017-12-11 | 2017-12-11 | A kind of children's antiseptic composition and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109498669A (en) * | 2018-12-12 | 2019-03-22 | 上海美哈医药科技有限公司 | A kind of antibacterial cream of psoriasis external application and preparation method thereof |
-
2017
- 2017-12-11 CN CN201711309503.7A patent/CN107802664A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109498669A (en) * | 2018-12-12 | 2019-03-22 | 上海美哈医药科技有限公司 | A kind of antibacterial cream of psoriasis external application and preparation method thereof |
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Application publication date: 20180316 |