CN105031032A - Traditional Chinese medicine composition and traditional Chinese medicine oral preparation for treating alopecia and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition and traditional Chinese medicine oral preparation for treating alopecia and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is composed of, by weight, 5-15 parts of ligusticum wallichii, 5-15 parts of polygonum multiflorum, 5-15 parts of pawpaws, 10-20 parts of angelica sinensis, 5-15 parts of notopterygium roots, 5-15 parts of barbary wolfberry fruits, 5-25 parts of radix rehmanniae, 2-10 parts of fructus psoraleae, 5-15 parts of roots of bidentate achyranthes, 5-15 parts of glossy privet fruits, 5-15 parts of white peony roots and 5-15 parts of poria cocos. The types of traditional Chinese medicines contained in the formula is fewer, and the formula is simple and reasonable. The traditional Chinese medicine oral preparation prepared from the traditional Chinese medicine composition is a pure traditional Chinese medicine preparation, and toxic and side effects are fewer in long-term taking. The traditional Chinese oral preparation is prepared through decoction and extraction, the preparation method is simple, convenient, easy to carry out and capable of being produced in a large scale. Combination of regulating and treating can be conducted on patients through the traditional Chinese medicine oral preparation, metabolism and internal secretion of the patients can be conducted orderly, and therefore a better effect for treating the alopecia is achieved.

Description

A kind of Chinese medicine composition, extract oral agent and preparation method thereof being used for the treatment of alopecia

Technical field

The invention belongs to technical field of Chinese medicine, be specifically related to a kind of Chinese medicine composition, extract oral agent and preparation method thereof that are used for the treatment of alopecia.

Background technology

Baldness, belonging to the sick scope such as the traditional Chinese medical science " alopecia areata ", " alopecia areata ", is the commonly encountered diseases in department of dermatologry, frequently-occurring disease.Clinically be divided into the types such as alopecia areata, seborrheic alopecia, senile alopecia, alopecia due to chemotherapy, and the highest with the sickness rate of alopecia areata and seborrheic alopecia.Motherland's medical science is early recognized alopecia, and discusses a lot of, about the record of alopecia sees "Nei Jing" the earliest, is referred to as alopecia areata,trichomadesis, deals with, trichomadesis.The traditional Chinese medical science is thought " hair is the sign of blood condition sends out the marquis for kidney "." all source of disease marquis opinions " is pointed out, " arteries and veins that punching is appointed is the sea of blood of sea of the twelve channels, meaning, lip on its other network, if blood is contained, flourish in beard and hair, therefore beard and hair is beautiful; Exhaust through deficient pulse if vim and vigour are weak, can not Rong Run, therefore beard and hair alopecia ".Below all illustrate that the growth of hair depends on gas, blood, essence." the capable then blood of gas ", " qi promoting blood production ", " gas does not consume, and returns and is skillful in kidney and is essence; Essence is not let out, and returns and is skillful in liver and changes purifying the blood ".

The growth of hair flourishing and withering with internal organs, QI and blood in close relations.Alopecia card is shown in multiterminal, but theoretical according to internal organs, and the cause of disease of alopecia is still this with deficiency of the liver and kindey, blood stasis, heat in blood, damp and hot be mark.But primary disease mostly is simulataneous insufficiency and excessive or Primary Asthenia-Secondary Sthenia Syndrome, along with the change of the external environment conditions such as social development, work rhythm, life style, alopecia is not only by empty and cause, especially due to the disease of the increase of stress and a kind of simulataneous insufficiency and excessive of the unbalance caused of diet.Hair growth Ying Congqi, blood, liver, kidney, the heart, spleen are started with, and blood nourishing and hair can be carried throughout, according to the difference of pattern of syndrome, or the moon of nourishing the liver and kidney, with raw cloudy blood; Or mend the taste day after tomorrow, and make QI and blood biochemistry active, in addition then can with card plus-minus for double disease.We's card is by prolonged illness QI and blood deficiency, and deficiency of the liver and kindey, essence does not change blood, blood not hair care, and the flesh natural fibre line of meat loses wet, sends out the source without growth, and Rhizoma Imperatae is hollow and deal with in flakes.Obstruction of collaterals by blood stasis, blood is unfluent, YANG-orifices failing to be nourished, then loss of hairs not life.Card is based on the hepatic and renal YIN deficiency, and obstruction of collaterals by blood stasis is auxiliaryly form alopecia, bald disease.

Modern medicine shows that the cause of disease of primary disease is still not clear so far, may with self heredity of patient, endocrine regulation, immune factor, psychoneural factor, vascular dysfunctions, infection, poisoning etc. relevant.Glucocorticoid, cyclosporin A, mecobalamin, vitamin E, Hirudoid ointment, minoxidil have certain therapeutical effect to alopecia.But these poisonous side effect of medicine are relatively large, and be not suitable for hair loss patient long-term prescription.

The traditional Chinese medical science is hair growth disease on the basis of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, has evident in efficacy, less or to have no side effect and without the advantage of drug dependence, therefore, the Chinese medicine study carrying out hair growth disease is significant.For the theory of Chinese medical science of the hepatic and renal YIN deficiency, obstruction of collaterals by blood stasis etc. in alopecia, suitable nourishing blood to expel wind, vital energy regualting and blood circulation-promoting, liver and kidney tonifying.Notification number is that " composition of medicine of a kind of hair growth, poliosis " of CN101284121B discloses a kind of Chinese medicine composition, and wherein comprise 30 multi-medicaments such as Radix Polygoni Multiflori, Poria, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Cordyceps, raw material is comparatively complicated.Publication No. is that " Chinese medicine composition of a kind of hair growth, poliosis and its preparation method and application " of CN104069402A discloses a kind of Chinese medicine composition, this Chinese medicine composition with Radix Polygoni Multiflori, Fructus Mori and Fructus Ligustri Lucidi for monarch drug, be equipped with other Chinese medicine, its oral agents preparation method is comparatively loaded down with trivial details.

Summary of the invention

First object of the present invention is to provide a kind of Chinese medicine composition being used for the treatment of alopecia.

Second object of the present invention is to provide a kind of extract oral agent being used for the treatment of alopecia.

3rd object of the present invention is to provide a kind of preparation method being used for the treatment of the extract oral agent of alopecia.

In order to realize above object, the technical solution adopted in the present invention is:

Be used for the treatment of a Chinese medicine composition for alopecia, be made up of the component of following parts by weight: Rhizoma Chuanxiong 5 ~ 15 parts, Radix Polygoni Multiflori 5 ~ 15 parts, Fructus Chaenomelis 5 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 5 ~ 15 parts, Fructus Lycii 5 ~ 15 parts, Radix Rehmanniae 5 ~ 25 parts, Fructus Psoraleae 2 ~ 10 parts, Radix Achyranthis Bidentatae 5 ~ 15 parts, Fructus Ligustri Lucidi 5 ~ 15 parts, the Radix Paeoniae Alba 5 ~ 15 parts, 5 ~ 15 parts, Poria.

Preferably, described in be used for the treatment of the Chinese medicine composition of alopecia, be made up of the component of following parts by weight: Rhizoma Chuanxiong 10 parts, Radix Polygoni Multiflori 10 parts, Fructus Chaenomelis 9 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Et Radix Notopterygii 9 parts, Fructus Lycii 10 parts, Radix Rehmanniae 15 parts, Fructus Psoraleae 6 parts, Radix Achyranthis Bidentatae 9 parts, Fructus Ligustri Lucidi 10 parts, the Radix Paeoniae Alba 10 parts, 10 parts, Poria.

Of the present inventionly be used for the treatment of in the Chinese medicine composition of alopecia, the function of each component is as follows:

Rhizoma Chuanxiong: acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel.Function blood-activating and qi-promoting, wind-expelling pain-stopping, is " the gas medicine in blood ", the sensible QI and blood effect of tool, therefore controls the breast side of body, all pains of abdominal part of qi depression to blood stasis.Effective ingredient master is containing ligustrazine, chuanxingol, ferulic acid.Can hemodynamics be improved, increase blood flow volume, reduce vascular resistance, increase limb artery, coronary flow, improve blood supply of cardiac muscle oxygen supply; Improve hemorheology, lower blood viscosity lowering and plasma viscosity and packed cell volume and erythrocyte electrophoretic time, blood flow cohesion ability declines, and has anti-thrombosis function.

Radix Polygoni Multiflori: bitter in the mouth, warm in nature, return liver, kidney channel.The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata energy, benefiting essence-blood, black beard and hair, bone and muscle strengthening, cure mainly blood deficiency and yellow complexion, vertigo and tinnitus, and early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body are empty.In recent years, the pharmacological research of Radix Polygoni Multiflori makes some progress, and the pharmacological action relevant to the kidney invigorating mainly concentrates on defying age, strengthens immunity, blood fat reducing, resists myocardial ischemia, improves the aspects such as cerebral ischemia, neuroprotective, osteoporosis.Radix Polygoni Multiflori nourishes blood because of the kidney invigorating and essence nourishing, and black hair, hair-growing effects are good, is clinically usually used in the diseases such as treatment poliosis, alopecia, alopecia areata.Stilbene methods of glycosides in Radix Polygoni Multiflori has stronger antioxidant activity in vitro and Scavenger of ROS effect, and has good dose-effect relationship, is a kind of stronger antioxidant.In Radix Polygoni Multiflori Preparata, polysaccharide composition has good immunoregulation effect, can promote Peritoneal Macrophage Phagocytosis, promotes that hemolysin and hemolysis plaque are formed, promotes lymphocyte transformation.The effects such as it improves immunoloregulation function, slow down aging, for it provides foundation in the treatment of the renal deficiency type diseases such as autoimmune disease, osteoporosis, cardiovascular and cerebrovascular disease.

Fructus Chaenomelis: sweet in the mouth, property is put down, and returns liver, spleen channel.Fructus Chaenomelis has effect of relaxing muscles and tendons, active, spleen benefiting and stimulating the appetite, Shugan Zhitong, expelling wind and removing dampness, can be used for prevention and therapy rheumatism, cholera, dysentery, enteritis, vitamin B1 deficiency and vitamin C deficiency etc.Fructus Chaenomelis is mainly containing flavonoid, organic acid, triterpenes, saponins, saccharide, tannin etc.Fructus Chaenomelis has anti-inflammatory and antalgic, strengthens immunomodulating, antitumor, the effect such as antibacterial.Containing protecting the liver chemical composition oleanolic acid and ursolic acid in Fructus Chaenomelis, having and alleviating hepatic necrosis, alleviate liver cell fatty degeneration, prevent swelling of liver cell, balloon sample from becoming, promote the effect that hepatocyte is repaired can reduce the effect of glutamate pyruvate transaminase in addition.

Radix Angelicae Sinensis: sweet in the mouth, warm in nature, return liver, the heart, spleen channel.Primary efficacy is invigorated blood circulation for enriching blood, menstruction regulating and pain relieving, moisturize laxation.Cure mainly the diseases such as all cards of blood deficiency, menoxenia.Radix Angelicae Sinensis is that the traditional Chinese medical science is enriched blood key medicine of invigorating blood circulation.Radix Angelicae Sinensis infusion significantly can promote hemoglobin and erythrocytic generation to Mouse oral.Its anti-anemia action effect may be relevant with contained vitamin B12, nicotinic acid, folinic acid and the composition such as biotin, folic acid.Radix Angelicae Sinensis polysaccharide can increase peripheral red blood cells, leukocyte, hemoglobin and bonemarrow nucleated cells number, and this effect is particularly particularly evident when periphery cytopenia and bone marrow are suppressed.One of Chinese angelica blood supplementing mechanism of action may stimulate pluripotential hemopoietic stem cell (CFU-S), proliferation of hematopoietic progenitors, differentiation relevant with Radix Angelicae Sinensis polysaccharide.

Fructus Lycii: sweet in the mouth, property is put down, and returns liver, kidney, lung meridian.Primary efficacy is nourishing the liver, nourishing kidney, lung moistening.Cure mainly caused by liver and kidney deficiency, have a dizzy spell, the visual disease such as unclear.Pharmaceutical research confirms, Fructus Lycii scalable body's immunity, effectively can grow and cell mutation by Tumor suppression, have the effect of the aspects such as slow down aging, anti-fatty liver, adjusting blood lipid and blood glucose.Therefore, Fructus Lycii has certain therapeutical effect to diabetes, dyslipidemia, abnormal liver function, gastritis etc.Long-term taking vitamin E-C mixture or lycium barbarum polysaccharide all can play the effect to free radical resisting to a certain extent, and nephridial tissue malonaldehyde level is declined, and prevention mitochondrion is aging, and its function is made moderate progress.

Rhizoma Et Radix Notopterygii: acrid in the mouth, hardship, warm in nature, enter bladder, kidney channel.There is expelling cold and relieving exterior syndrome, expelling wind and dampness, effect of eliminating impediment pain relieving.Cure mainly affection of exogenous wind-cold, rheumatism, fever with aversion to cold is lossless, and headache stiffness of the nape, blurred vision is had a stuffy nose, limb aching pain, anemofrigid-damp arthralgia, edema beriberi, sore swollen toxin, tetanus.Modern pharmacological research Rhizoma Et Radix Notopterygii has antipyretic, analgesic activity.

Radix Rehmanniae: sweet in the mouth, warm in nature.GUIXIN, liver, kidney channel.Radix Rehmanniae Preparata is key medicine of enriching blood, normal and Radix Angelicae Sinensis, the same use of the Radix Paeoniae Alba, and with disease compatibility relative medicine.For blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, metrorrhagia etc.Radix Rehmanniae Preparata normal with Radix Polygoni Multiflori Preparata, Fructus Lycii, Semen Cuscutae etc. replenishing vital essence and blood, black beard and hair medicine use together.For the soreness of the waist and knees, vertigo and tinnitus, early whitening of beard and hair etc. of Liver and kidney blood and essence asthenia.Modern study shows, Radix Rehmanniae Preparata is containing catalpol, rehmanin, mannitol, retinoid material, saccharide and aminoacid etc.There are heart tonifying, diuresis, blood sugar lowering and rising peripheral leukocytes, strengthen the effects such as immunologic function.Radix Rehmanniae has hemostasis and promotes the pharmacologically active of blood cell proliferation, simultaneously can by affecting leukocyte and platelet carrys out antiinflammatory.Radix Rehmanniae, by some cell in number of ways activating machine soma, particularly hematopoieticmicroenviron-ment, promotes that it is secreted multiple hemopoietic growth factor and strengthens the propagation of hemopoietic progenitor cell.

Fructus Psoraleae: acrid in the mouth, hardship, warm in nature, return kidney, spleen channel.There is warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, effect of antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External treatment is used for dermatosis, vitiligo, alopecia etc.The Coumarins such as psoralen, isopsoralen composition and the flavones ingredient such as Corylin., Bavachalcone are the main components that Fructus Psoraleae plays drug effect.There is antitumor and metastasis, the T cell propagation of suppression superantigen, the ability improving body nonspecific immunity, the anti-ageing effect of waiting for a long time.Corylifolinin in Fructus Psoraleae, the coronary vasodilator of expansible Cavia porcellus, rabbit, cat, isolated rat heart, and the contraction of pituitrin to arteria coronaria can be resisted; Fructus Psoraleae regulates the metabolism such as sugar, nucleic acid and protein in addition, recovers mitochondrial function, improves the effect of cell hydride functional.

Radix Achyranthis Bidentatae: sweet in the mouth, micro-hardship, property is put down, and returns liver, kidney channel.Eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.The chemical composition of Radix Cyathulae is mainly alkaloid and ketosteroid, as cyasterone, capitasterone, ecdysone, red sterone etc.Radix Cyathulae can reduce plasma viscosity, strengthens erythrocyte deformability, extends blood plasma recalcification time, improves microcirculation.Radix Achyranthis extracting solution has stronger resist inflammation on repercussive function, improves body's immunity.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, cool in nature, return liver, kidney channel.There is nourishing the liver and kidney, the merit of black hair improving eyesight.Cure mainly the hepatic and renal YIN deficiency, the head is giddy, Hiccough and deaf, early whitening of hair, the diseases such as soreness of the waist and knees.Containing oleanolic acid, mannitol, linoleic acid, Fructus Ligustri Lucidi element etc. and a large amount of glucoses.Fructus Ligustri Lucidi has immunity moderation function, antibacterial, antiinflammatory, antitumor, antiplatelet aggregation, blood sugar lowering, blood fat reducing, protects the liver, anti-ageing pharmacological action of waiting for a long time.Fructus Ligustri Lucidi can promote hair follicle growth, has potentiation to people's Scalp hair follicles of In vitro culture; Molecular biology research shows that Fructus Ligustri Lucidi can strengthen the expression of mouse hair follicles hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) mRNA, though effective ingredient oleanolic acid can not improve the expression of hair follicle VEGF, the expression of HGF can be strengthened.

The Radix Paeoniae Alba: bitter in the mouth acid, is slightly cold, cool in nature, enters liver, spleen channel.There is the effects such as easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receipts antiperspirant, be applicable to fever due to yin deficiency, menoxenia, breast abdominal rib pain, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.Containing peoniflorin, also containing peony lactone benzoic acid.Peoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.Have invigorating qi and benefiting blood for human body, nourish conditioning vim and vigour, liver's asthenic fire is calmed down by the liver of dredging people, analgesic antiphlogistic.The effect of promoting blood circulation and stopping pain can be used for the phenomenons such as each organ pain on treatment health, blood is obstructed.

Poria: sweet in the mouth, property is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Mild in medicine property and, dampness removing and do not hinder healthy energy.Dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis can be controlled, have loose bowels, pass out semen, stranguria with turbid discharge, palpitation with fear, the disease such as forgetful.Su-fuling is the main component of inducing diuresis to remove edema, the Na on energy active cell film ⁺-K ⁺-ATP enzyme, and ATP is relevant with diuresis.Su-fuling is new aldosterone receptor antagonist, is conducive to urine and discharges, recover renal function, eliminate protein.Poria seat of local government has the effect of enhancing immunity, antitumor and calmness, blood sugar lowering etc. containing pachymic acid.Discovered in recent years Poria has the novelty teabag such as treatment hepatitis, cardiopalmus, schizophrenia, alopecia areata.

Medication meridian attribution analysis shows, and we's card is by prolonged illness QI and blood deficiency, and deficiency of the liver and kindey, essence does not change blood, blood not hair care, and the flesh natural fibre line of meat loses wet, sends out the source without growth, and Rhizoma Imperatae is hollow and deal with in flakes.Obstruction of collaterals by blood stasis, blood is unfluent, YANG-orifices failing to be nourished, then loss of hairs not life.Card is based on the hepatic and renal YIN deficiency, and obstruction of collaterals by blood stasis is auxiliaryly form alopecia, bald disease.Therefore reuse Radix Rehmanniae in side and to enrich blood YIN nourishing, be monarch drug.Minister is with the Radix Polygoni Multiflori, and the flat invigorating the liver and kidney of Fructus Ligustri Lucidi, benefiting essence-blood, impels Liver and kidney side to damage and reverse.Originator, after blood, blood stored in the liver, therefore send out as liver blood is led, liver blood side is empty, is not enough to flourish women's head-ornaments, then sends out and easily come off, thus with Radix Angelicae Sinensis, Fructus Lycii, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, Fructus Chaenomelis, with replenishing blood and nourishing liver, easypro network of invigorating blood circulation, short blood fills and reaches women's head-ornaments; Above-mentioned all medicines, the product of polyphyly Zishen fill fine, nourshing blood and promoting blood circulation are anti-cloudy nothingization, so Fructus Psoraleae warming the kidney to activate YANG; The Radixs Polygoni Multiflori etc. grow greasy product, and it is turbid probably to hinder letting out of bladder, therefore mix with letting out of oozing of Poria turbid.Above-mentioned all medicines are adjuvant drug altogether.Make with Rhizoma Et Radix Notopterygii, priming is up, and top, through mountain peak, makes efficacy of a drug common fault institute.

The dosage form that the Chinese medicine composition being used for the treatment of alopecia of the present invention can be made into field of Chinese medicines routine is taken, dosage form as medically acceptable in oral agents etc.Such as, each component will be measured by formula, and make oral agents after decocting with water and directly take.

Be used for the treatment of an extract oral agent for alopecia, the raw material of Chinese medicine primarily of following parts by weight is made: Rhizoma Chuanxiong 5 ~ 15 parts, Radix Polygoni Multiflori 5 ~ 15 parts, Fructus Chaenomelis 5 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 5 ~ 15 parts, Fructus Lycii 5 ~ 15 parts, Radix Rehmanniae 5 ~ 25 parts, Fructus Psoraleae 2 ~ 10 parts, Radix Achyranthis Bidentatae 5 ~ 15 parts, Fructus Ligustri Lucidi 5 ~ 15 parts, the Radix Paeoniae Alba 5 ~ 15 parts, 5 ~ 15 parts, Poria.

Preferably, described in be used for the treatment of the extract oral agent of alopecia, the raw material of Chinese medicine primarily of following parts by weight is made: Rhizoma Chuanxiong 10 parts, Radix Polygoni Multiflori 10 parts, Fructus Chaenomelis 9 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Et Radix Notopterygii 9 parts, Fructus Lycii 10 parts, Radix Rehmanniae 15 parts, Fructus Psoraleae 6 parts, Radix Achyranthis Bidentatae 9 parts, Fructus Ligustri Lucidi 10 parts, the Radix Paeoniae Alba 10 parts, 10 parts, Poria.

Be used for the treatment of a preparation method for the extract oral agent of alopecia, comprise the following steps:

1) measure raw material of Chinese medicine by formula, decoct with water for twice, collecting decoction;

2) by step 1) filtration of gained decocting liquid, filtrate concentrated, secondary filter after cold preservation, to obtain final product.

Step 1) in, describedly to decoct with water for twice, soak after first time adds water after 20 ~ 40 minutes and decoct; Each decoction adds water all dipped medical material surface 5 ~ 15cm, and each decocting time is 0.5 ~ 1.5 hour.

Step 2) in, described filtration and secondary filter all adopt 5 layers of gauze to filter.

Step 2) in, described concentrated be that filtrate to be concentrated into relative density be 1.05 ~ 1.20.

Step 2) in, the temperature of described cold preservation is 4 DEG C, and cold preservation time is 12 ~ 36 hours.

Step 2) in, add purified water after described secondary filter and carry out standardize solution, the amount adding purified water is: every 1 ~ 1.4g raw material of Chinese medicine correspondence adds water 1mL.

Step 2) in, described in add purified water after carry out sterilizing, sterilizing adopts 100 DEG C of flowing steam sterilizations 30 minutes.

Described in the technical scheme of above-mentioned Chinese medicine composition, extract oral agent and extract oral agent preparation method, Radix Polygoni Multiflori is Radix Polygoni Multiflori Preparata, and described Radix Achyranthis Bidentatae is Radix Cyathulae.

Beneficial effect of the present invention:

The Chinese medicine composition being used for the treatment of alopecia of the present invention, adopts Rhizoma Chuanxiong, Radix Polygoni Multiflori, Fructus Chaenomelis, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Fructus Lycii, Radix Rehmanniae, Fructus Psoraleae, Radix Achyranthis Bidentatae, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Poria to carry out composite, formula advantages of simple, determined curative effect; Traditionally differential diagnosis in tcm is theoretical, except invigorating QI and tranquilization, outside the effect such as nourishing the liver and kidney, also focuses on depressed liver-energy dispersing and QI regulating, righting gas of rectifying, and is improving in alopecia symptom evident in efficacy, is having significant therapeutic effect to the alopecia caused by hepatic and renal function imbalance, obstruction of collaterals by blood stasis; The oral agents that the Chinese medicine composition being used for the treatment of alopecia of the present invention is made is pure Chinese medicinal preparation, and long-term taking toxic and side effects is less; Adopt the method for oral drugs that patient is implemented to tune, controls combination, deduct the flow process that external is loaded down with trivial details, and patient's metabolism and endocrine are carried out in order, thus realize the treatment to alopecia.

The oral agents that the above-mentioned Chinese medicine composition of employing of the present invention is made is that can improve the stability of medicine and the compliance of patient, clinical practice is evident in efficacy, and is convenient for carrying and takes by decocting the Chinese medicine preparation extracting and make.Preparation method is simple and easy to do, can carry out large-scale production.

Detailed description of the invention

Following embodiment is only described in further detail the present invention, but does not form any limitation of the invention.

Embodiment 1

The Chinese medicine composition of the present embodiment, is made up of the component of following parts by weight: Rhizoma Chuanxiong 10 parts, Radix Polygoni Multiflori Preparata 10 parts, Fructus Chaenomelis 9 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Et Radix Notopterygii 9 parts, Fructus Lycii 10 parts, Radix Rehmanniae 15 parts, Fructus Psoraleae 6 parts, Radix Cyathulae 9 parts, Fructus Ligustri Lucidi 10 parts, the Radix Paeoniae Alba 10 parts, 10 parts, Poria.

The extract oral agent being used for the treatment of alopecia of the present embodiment, the raw material of Chinese medicine primarily of following parts by weight forms: Rhizoma Chuanxiong 10 parts, Radix Polygoni Multiflori Preparata 10 parts, Fructus Chaenomelis 9 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Et Radix Notopterygii 9 parts, Fructus Lycii 10 parts, Radix Rehmanniae 15 parts, Fructus Psoraleae 6 parts, Radix Cyathulae 9 parts, Fructus Ligustri Lucidi 10 parts, the Radix Paeoniae Alba 10 parts, 10 parts, Poria.

The preparation method being used for the treatment of the extract oral agent of alopecia of the present embodiment, comprises the following steps:

1) raw material of Chinese medicine is measured by formula, add water dipped medical material surface 10cm, soak 30 minutes, decoct 1 hour, taken out by a decocting liquid, then add water dipped medical material surface 10cm in the raw material of Chinese medicine decocted, and decocts 1 hour, take out secondary decocting liquid, twice gained decocting liquid is merged and obtains final decocting liquid;

2) step 1 is got) the final decocting liquid of gained, by 5 layers of filtered through gauze, getting filtrate, to be concentrated into relative density be 1.15, cold preservation 24 hours under 4 DEG C of conditions, use 5 layers of gauze secondary filter again, obtain secondary filtrate, get secondary filtrate and add purified water and dilute, the amount adding purified water is that every 1.2g raw material of Chinese medicine correspondence adds water 1mL, mixing, subpackage, 100 DEG C of flowing steam sterilizations 30 minutes, must be used for the extract oral agent of hair growth.

The extract oral agent using method being used for the treatment of alopecia of the present embodiment is as follows:

Specification: 250mL/ bottle.

Usage and consumption: oral, 2 times on the one, a 50mL.

Taboo and points for attention: take in process and should be careful in one's diet, avoid cold and uncooked food, greasy, pungent.

Embodiment 2

The Chinese medicine composition of the present embodiment, is made up of the component of following parts by weight: Rhizoma Chuanxiong 5 parts, Radix Polygoni Multiflori Preparata 5 parts, Fructus Chaenomelis 5 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Et Radix Notopterygii 5 parts, Fructus Lycii 5 parts, Radix Rehmanniae 5 parts, Fructus Psoraleae 2 parts, Radix Cyathulae 5 parts, Fructus Ligustri Lucidi 5 parts, the Radix Paeoniae Alba 5 parts, 5 parts, Poria.

The extract oral agent being used for the treatment of alopecia of the present embodiment, the raw material of Chinese medicine primarily of following parts by weight forms: Rhizoma Chuanxiong 5 parts, Radix Polygoni Multiflori Preparata 5 parts, Fructus Chaenomelis 5 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Et Radix Notopterygii 5 parts, Fructus Lycii 5 parts, Radix Rehmanniae 5 parts, Fructus Psoraleae 2 parts, Radix Cyathulae 5 parts, Fructus Ligustri Lucidi 5 parts, the Radix Paeoniae Alba 5 parts, 5 parts, Poria.

The preparation method being used for the treatment of the extract oral agent of alopecia of the present embodiment, comprises the following steps:

1) raw material of Chinese medicine is measured by formula, add water dipped medical material surface 5cm, soak 20 minutes, decoct 0.5 hour, taken out by a decocting liquid, then add water dipped medical material surface 5cm in the raw material of Chinese medicine decocted, and decocts 0.5 hour, take out secondary decocting liquid, twice gained decocting liquid is merged and obtains final decocting liquid;

2) step 1 is got) the final decocting liquid of gained, by 5 layers of filtered through gauze, getting filtrate, to be concentrated into relative density be 1.05, cold preservation 12 hours under 4 DEG C of conditions, use 5 layers of gauze secondary filter again, obtain secondary filtrate, get secondary filtrate and add purified water and dilute, the amount adding purified water is that every 1g raw material of Chinese medicine correspondence adds water 1mL, mixing, subpackage, 100 DEG C of flowing steam sterilizations 30 minutes, must be used for the extract oral agent of hair growth.

The extract oral agent using method being used for the treatment of alopecia of the present embodiment is as follows:

Specification: 250mL/ bottle.

Usage and consumption: oral, 2 times on the one, a 50mL.

Taboo and points for attention: take in process and should be careful in one's diet, avoid cold and uncooked food, greasy, pungent.

Embodiment 3

The Chinese medicine composition of the present embodiment, is made up of the component of following parts by weight: Rhizoma Chuanxiong 15 parts, Radix Polygoni Multiflori Preparata 15 parts, Fructus Chaenomelis 15 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Et Radix Notopterygii 15 parts, Fructus Lycii 15 parts, Radix Rehmanniae 25 parts, Fructus Psoraleae 10 parts, Radix Cyathulae 15 parts, Fructus Ligustri Lucidi 15 parts, the Radix Paeoniae Alba 15 parts, 15 parts, Poria.

The extract oral agent being used for the treatment of alopecia of the present embodiment, the raw material of Chinese medicine primarily of following parts by weight forms: Rhizoma Chuanxiong 15 parts, Radix Polygoni Multiflori Preparata 15 parts, Fructus Chaenomelis 15 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Et Radix Notopterygii 15 parts, Fructus Lycii 15 parts, Radix Rehmanniae 25 parts, Fructus Psoraleae 10 parts, Radix Cyathulae 15 parts, Fructus Ligustri Lucidi 15 parts, the Radix Paeoniae Alba 15 parts, 15 parts, Poria.

The preparation method being used for the treatment of the extract oral agent of alopecia of the present embodiment, comprises the following steps:

1) raw material of Chinese medicine is measured by formula, add water dipped medical material surface 15cm, soak 40 minutes, decoct 1.5 hours, taken out by a decocting liquid, then add water dipped medical material surface 15cm in the raw material of Chinese medicine decocted, and decocts 1.5 hours, take out secondary decocting liquid, twice gained decocting liquid is merged and obtains final decocting liquid;

2) step 1 is got) the final decocting liquid of gained, by 5 layers of filtered through gauze, getting filtrate, to be concentrated into relative density be 1.20, cold preservation 36 hours under 4 DEG C of conditions, use 5 layers of gauze secondary filter again, obtain secondary filtrate, get secondary filtrate and add purified water and dilute, the amount adding purified water is that every 1.4g raw material of Chinese medicine correspondence adds water 1mL, mixing, subpackage, 100 DEG C of flowing steam sterilizations 30 minutes, must be used for the extract oral agent of hair growth.

The extract oral agent using method being used for the treatment of alopecia of the present embodiment is as follows:

Specification: 250mL/ bottle.

Usage and consumption: oral, 2 times on the one, a 50mL.

Taboo and points for attention: take in process and should be careful in one's diet, avoid cold and uncooked food, greasy, pungent.

Experimental example

This experimental example carries out clinical observation on the therapeutic effect to the extract oral agent being used for the treatment of alopecia in embodiment 1.

For being used for the treatment of the therapeutic effect of the extract oral agent of alopecia in checking embodiment 1, carried out efficiency assay in The First Affiliated Hospital of Henan University of Science and Technology, clinical test results is as follows:

1. physical data

(1) Disease Diagnosis Standard:

Western medicine diagnose standard is with reference to Ministry of Health of the People's Republic of China " new Chinese medicine guideline of clinical investigations ":

1. alopecia areata: suddenly or hair flaking in a short time, single-shot or multiple, even hair all comes off, and eyebrow, armpit hair, pubes, beard and fine hair on birds or animals hair come off; Alopecia district color of the leather is normal, and without obvious inflammatory reaction, skin has no atrophy and cicatrix.2. seborrheic alopecia: fat secretion is prosperous, hair is greasy, or the dandruff is obvious, and hair is dry, with pruritus; Hair diffusivity slowly comes off, and hair is sparse in male pattern alopecia.

(2) inclusive criteria: meet alopecia areata, seborrheic alopecia diagnostic criteria and Chinese medical discrimination person.

(3) exclusion standard: 1. the age is at under-18s or over-65s, gestation or women breast-feeding their children, allergic constitution or those who are allergic to this drug; 2. the severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system are associated with, psychotic; 3. congenital alopecia: acomia or see the bad and rare person of hair development wholly or in part for genetic reasons; 4. posteriority alopecia: endocrine dysfunction disease, serious acute infectious disease, chronic disease is as tuberculosis, liver cirrhosis etc., and dermatosis is as syphilis, leprosy etc. and because of the causer such as medicine, wound; 5. cicatricial alopecia: infective factors is as tinea favosa, folliculitis decalvans etc., some non-infectious dermatosis is as lichen planus, local scleroderma etc., vegetation is as sebaceous nevus, basal cell epithelium disease etc., and other are as mechanicalness, radioactivity reason causer; 6. do not meet inclusive criteria, not by regulation medication, cannot curative effect be judged, or data is not congruent affects the treatment or safety judgement person.

2. divide into groups

65 routine patients are outpatient, wherein male 41 example, women 24 example; Between 21 ~ 45 years old age, 33 years old mean age; The course of disease 1 month ~ 2 years; Alopecia areata 43 example, seborrheic alopecia 22 example; Chinese medical discrimination: deficiency of the liver and kindey 25 example, blood stasis hair key 18 example, damp-heat in the spleen and stomach 7 example, blood hot air wind producing 7 example, blood deficiency cervical carcinoma with cachexia 8 example.

3. research method

Each group of case is stopped using other Therapeutic Method at least 3 week before the treatment, then the daily extract oral agent that provides of the embodiment of the present invention 1, a 50mL, 2 times on the one.Further consultation 1 time in every 2 weeks 1 month is 1 course for the treatment of, takes more than 3 months persons continuously as statistics case.Take in process and should be careful in one's diet, avoid cold and uncooked food, greasy, pungent.

4. curative effect determinate standard

With reference to Ministry of Health of the People's Republic of China " new Chinese medicine guideline of clinical investigations ".

Clinical recovery: hair stops coming off, and alopecia all grows, and its distribution density, thickness, color and luster are identical with Jian Fa district, sebum secretion recovers normal; Effective: hair stops coming off, and hair replacement reaches 70%, and its density, thickness and color and luster are all close to Jian Fa district, and sebum secretion obviously reduces; Effective: hair stops coming off, and hair replacement reaches 30%, comprises fine hair on birds or animals hair and poliosis grows.Invalid: hair replacement is less than 30% or continue to come off.

5. result of study

Clinical recovery 38 example, accounts for 58.46%; Effective 17 examples, account for 26.15%; Effective 8 examples, account for 12.31%; Total effective rate is 97%.The course for the treatment of the longest 15 courses for the treatment of, the shortest 3 courses for the treatment of, 8 courses for the treatment of of average out to.

Table 1 is used for the treatment of the extract oral agent lanqin oral solutions result of alopecia

6. conclusion

In various alopecia differentiation of symptoms and signs for classification of syndrome, at most, curative effect is better, and cure rate is also high, illustrates that the Chinese medicine composition of hair growth of the present invention leads to stagnant based on nourishing the liver and kidney, blood stasis dispelling, nourshing blood and promoting blood circulation for deficiency of the liver and kindey type and blood stasis hair key type case, and the congenial then effect of medicine card is rather good.

Model case

Model case 1: Chen, female, 36 years old, laid-off worker, suffered from alopecia some months, and through many places, effect is deceived in treatment.Examine over 2008, disease sees that hair, eyebrow, armpit hair, pubes are general de-, and what Rhizoma Imperatae touched easily falls, scalp pruritus, and hands presses the ball of scalp as depletion of QI, grief shape, urine night frequently, band still can, thready and weak pulse, light purplish tongue, yellow and thin fur, there is petechia on the tip of the tongue tongue limit, and back is pale purple.Diagnosis: alopecia areata.Take the extract oral agent of the embodiment of the present invention 1, after 1 course for the treatment of (1 month), alopecia place starts to grow fine fleece and newly sends out, and scalp itch alleviates.Use 2 courses for the treatment of again, the state of an illness is improved further, and kainogenesis is better long, without scalp itch.3 courses for the treatment of of SM, alopecia is fully recovered, and kainogenesis is better long, and the hair quality amount of sending out returns to the front health status of disease, follows up a case by regular visits to not alopecia again half a year.

Model case 2: Lee, man, 18 years old.Patient does manual work in other places, normal cryostat, starts front frontal eminence then, crown hair is sparse and scattered, sends out carefully soft, scalp pruritus, has dandruff greasy, fails to respond to any medical treatment in various places, many places, examines over 2009, disease sees head alopecia totalis, and eyebrow, armpit hair, pubes come off gradually, only residual a little fine, soft fur, and times of defecation frequently, the tired dizziness of god, hyperhidrosis is uncomfortable in chest, and then waist of bowing for a long time is stiff, light purplish tongue, has spot of oil cavity, and white and thin fur is greasy spot of oil cavity, the tip of the tongue tongue limit no fur, the light red and greasy fur of back, soft and thready pulse.Diagnosis: androgenetic alopecia.Take the extract oral agent of the embodiment of the present invention 2, take to 1 course for the treatment of, scalp is not scratched where it itches, and sebum secretion obviously reduces, and takes alopecia position hair to 3 courses for the treatment of and starts generally to grow, then hair start gradually black by xanthochromia, by carefully thicker, close by rare change.Control 6 courses for the treatment of altogether, substantially recover sick front original appearance.

Model case 3: Chen, female, 40 years old.Alopecia more than 1 year.Seek medical advice in my institute over 2000.Disease is seen: hair is that Progressive symmetric erythrokeratodermia comes off, and scalp is red, light, and formicant itching, relates to full head, and dizziness headache, singultus uncomfortable in chest, insomnia dream is many, cardiopalmus sometimes, susceptible to lose temper due to restlessness, flushed face, red tongue, few tongue, stringy and thready pulse.Card belongs to stagnation of QI due to depression of the liver, with depressed liver-energy dispersing and QI regulating, and nourishing kidney nourishing blood to suppress the hyperactive liver.After taking 1 course for the treatment of of extract oral agent of the embodiment of the present invention 3, above-mentioned all proofs are aobvious to be alleviated, and head fine hair on birds or animals hair is generally newborn, when clothes are to 2 courses for the treatment of, above-mentioned all cards disappear substantially then, and newborn hair is by the blackening gradually of leucismus Huang, change software strategy into software-hardware strategy, by carefully thicker, close by rare change.Control 4 courses for the treatment of altogether, substantially recover sick front original appearance.

Claims (9)

1. be used for the treatment of a Chinese medicine composition for alopecia, it is characterized in that, be made up of the component of following parts by weight: Rhizoma Chuanxiong 5 ~ 15 parts, Radix Polygoni Multiflori 5 ~ 15 parts, Fructus Chaenomelis 5 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 5 ~ 15 parts, Fructus Lycii 5 ~ 15 parts, Radix Rehmanniae 5 ~ 25 parts, Fructus Psoraleae 2 ~ 10 parts, Radix Achyranthis Bidentatae 5 ~ 15 parts, Fructus Ligustri Lucidi 5 ~ 15 parts, the Radix Paeoniae Alba 5 ~ 15 parts, 5 ~ 15 parts, Poria.

2. Chinese medicine composition according to claim 1, is characterized in that, is made up of the component of following parts by weight: Rhizoma Chuanxiong 10 parts, Radix Polygoni Multiflori 10 parts, Fructus Chaenomelis 9 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Et Radix Notopterygii 9 parts, Fructus Lycii 10 parts, Radix Rehmanniae 15 parts, Fructus Psoraleae 6 parts, Radix Achyranthis Bidentatae 9 parts, Fructus Ligustri Lucidi 10 parts, the Radix Paeoniae Alba 10 parts, 10 parts, Poria.

3. be used for the treatment of an extract oral agent for alopecia, it is characterized in that, the raw material of Chinese medicine primarily of following parts by weight is made: Rhizoma Chuanxiong 5 ~ 15 parts, Radix Polygoni Multiflori 5 ~ 15 parts, Fructus Chaenomelis 5 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Rhizoma Et Radix Notopterygii 5 ~ 15 parts, Fructus Lycii 5 ~ 15 parts, Radix Rehmanniae 5 ~ 25 parts, Fructus Psoraleae 2 ~ 10 parts, Radix Achyranthis Bidentatae 5 ~ 15 parts, Fructus Ligustri Lucidi 5 ~ 15 parts, the Radix Paeoniae Alba 5 ~ 15 parts, 5 ~ 15 parts, Poria.

4. be used for the treatment of the extract oral agent of alopecia according to claim 3, it is characterized in that, the raw material of Chinese medicine primarily of following parts by weight is made: Rhizoma Chuanxiong 10 parts, Radix Polygoni Multiflori 10 parts, Fructus Chaenomelis 9 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Et Radix Notopterygii 9 parts, Fructus Lycii 10 parts, Radix Rehmanniae 15 parts, Fructus Psoraleae 6 parts, Radix Achyranthis Bidentatae 9 parts, Fructus Ligustri Lucidi 10 parts, the Radix Paeoniae Alba 10 parts, 10 parts, Poria.

5. be used for the treatment of a preparation method for the extract oral agent of alopecia as claimed in claim 3, it is characterized in that, comprise the following steps:

1) measure raw material of Chinese medicine by formula, decoct with water for twice, collecting decoction;

2) by step 1) filtration of gained decocting liquid, filtrate concentrated, secondary filter after cold preservation, to obtain final product.

6. the preparation method being used for the treatment of the extract oral agent of alopecia according to claim 5, is characterized in that, step 1) described in decoct with water for twice, soak after first time adds water after 20 ~ 40 minutes and decoct; Each decoction adds water all dipped medical material surface 5 ~ 15cm, and each decocting time is 0.5 ~ 1.5 hour.

7. the preparation method being used for the treatment of the extract oral agent of alopecia according to claim 5, is characterized in that, step 2) described in filter and secondary filter all adopt 5 layers of gauze to filter.

8. the preparation method being used for the treatment of the extract oral agent of alopecia according to claim 5, is characterized in that, step 2) described in concentrated be that filtrate to be concentrated into relative density be 1.05 ~ 1.20.

9. the preparation method being used for the treatment of the extract oral agent of alopecia according to claim 5, is characterized in that, step 2) described in the temperature of cold preservation be 4 DEG C, cold preservation time is 12 ~ 36 hours.