CN105012435A - Traditional Chinese medicine composition treating yin-deficiency type postcholecystectomy syndrome - Google Patents
Traditional Chinese medicine composition treating yin-deficiency type postcholecystectomy syndrome Download PDFInfo
- Publication number
- CN105012435A CN105012435A CN201510443422.0A CN201510443422A CN105012435A CN 105012435 A CN105012435 A CN 105012435A CN 201510443422 A CN201510443422 A CN 201510443422A CN 105012435 A CN105012435 A CN 105012435A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- deficiency type
- yin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a traditional Chinese medicine composition treating yin-deficiency type postcholecystectomy syndrome. The traditional Chinese medicine composition is prepared from the following bulk drugs: carapax et plastrum testudinis, fruit of russianolive, fruit of leatherleaf mahonia, semen podocarpi macrophylli, embelia parviflora Wall., polytrichum commune L.ex Hedw., leaf of leatherleaf mahonia, loquat seed, and prunus mume Sieb. Et Zucc. var. Viridicalyx Makino. The provided traditional Chinese medicine composition treating yin-deficiency type postcholecystectomy syndrome has the advantages of simpleness, convenience, cheapness, effectiveness and the like for treating yin-deficiency type postcholecystectomy syndrome. When the traditional Chinese medicine composition treating yin-deficiency type postcholecystectomy syndrome is used to treat 40 patients for 4 weeks in the form of a water decoctum, the composition helps to cure 20 examples, achieve substantial effect on 13 examples, achieve effect on 5 examples, and achieve no effect on 2 examples, and the total effective rate is 95.0%.
Description
Technical field
The present invention relates to Chinese medicine sciemtifec and technical sphere, particularly a kind of Chinese medicine composition for the treatment of YIN-deficiency type post-cholecystectomy syndrome.
Background technology
The clinical syndrome relevant with gallbladder system pathological changes that post-cholecystectomy syndrome system occurs due to postcholecystectomy.It is generally acknowledged about have 25% ~ 30% can occur transient symptom after gallbladder removal, can disappear very soon, about have 2% ~ 8% because of Symptoms last, and need active treatment.Post-cholecystectomy syndrome formative factor is numerous and diverse, and current etiological diagnosis remains in certain difficulty.Simple symptomatic treatment unsatisfactory curative effect, and Chinese medicine has rich experience in liver, gallbladder, spleen, gastrotherapy, and have original understanding for primary disease.But due to the complexity of primary disease pathogenesis, single prescription effectively cannot treat all post-cholecystectomy syndrome patients, necessary medicine typing, then takes corresponding remedy measures.With the passing of time, consumption impairing the liver is cloudy for the many delays of YIN-deficiency type post-cholecystectomy syndrome, and treatment difficulty increases.The present inventor, by long-term clinical practice, develops a kind of Chinese medicine composition for the treatment of YIN-deficiency type post-cholecystectomy syndrome, satisfactory effect.
Summary of the invention
The object of the invention is to the deficiency overcoming prior art, namely provide one to treat YIN-deficiency type post-cholecystectomy syndrome Chinese medicine composition.
In order to realize foregoing invention object, the invention provides following technical scheme:
Treat a Chinese medicine composition for YIN-deficiency type post-cholecystectomy syndrome, be made up of the crude drug of following mass ratio:
Carapax Et Plastrum Testudinis 15 ~ 25 parts, 20 ~ 30 parts, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 6 ~ 10 parts, Semen Podocarpi Macrophylli 10 ~ 20 parts, Radix seu Caulis Embeliae Parviflorae 20 ~ 30 parts, 15 ~ 25 parts, native Iuba Equi, Folium Mahoniae 6 ~ 10 parts, Radix Eriobotryae 9 ~ 15 parts, FLOS MUME 3 ~ 5 parts.
The pharmacological action of raw material of Chinese medicine medicine of the present invention is as follows:
Carapax Et Plastrum Testudinis: sweet, cold, returns kidney, liver, heart channel.YIN nourishing, YANG hyperactivity suppressing, replenishing kidney and strengthening bone, reinforcing the heart of nourishing blood.Cure mainly the hepatic and renal YIN deficiency hyperactivity of YANG due to deficiency of YIN extremely, yin asthenia generating intrinsic heat, stirring of wind due to deficiency of YIN card, muscles and bones flaccidity of suffering from a deficiency of the kidney is weak, the palpitation with fear of deficiency of YIN-blood, insomnia, forgetful.
Fructus Elaeagni Angustifoliae: sour, micro-sweet, cool.Liver-nourishing kidney-boosting, spleen invigorating regulating menstruation.Cure mainly deficiency of the liver dizzy, lumbago due to renal deficiency, insufficiency of the spleen diarrhoea, dyspepsia, leukorrhagia, menoxenia.
Fructus Mahoniae: bitter, cool.Tonifying the lung, kidney tonifying, clearind deficient heat.Cure mainly pulmonary tuberculosis, osteopyrexia and fever, spitting of blood, soreness of the waist and knees, dizziness and tinnitus, metrorrhagia, leukorrhagia, stranguria with turbid discharge.
Semen Podocarpi Macrophylli: sweet, tepor.Promoting the circulation of QI to relieve pain, nourish blood.Cure mainly gastralgia, blood deficiency shallow complexion.
Radix seu Caulis Embeliae Parviflorae: bitter, puckery, warm.Tonifying blood and regulating menstruation, strong waist knee joint.Cure mainly anemia, amenorrhea, menoxenia, leucorrhea, lumbago and skelalgia.
Soil Iuba Equi: sweet, cold.Nourishing YIN and clearing away heat, cooling blood for hemostasis, loosening bowel to relieve constipation.Cure mainly deficiency of YIN hectic fever due to YIN-deficiency, hectic fever night sweat, pulmonary tuberculosis cough, heat in blood is spitted blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia, constipation and anuresis.
Folium Mahoniae: bitter, cold, return lung, liver, kidney channel.Clearind deficient heat, removing toxic substances.Cure mainly pulmonary tuberculosis hemoptysis, osteopyrexia and fever, soreness of waist and knee joint, jaundice due to damp-heat, leukorrhagia, dysentery, anemopyretic cold, conjunctival congestion and swelling pain.
Radix Eriobotryae: bitter, flat, mild toxicity, returns lung, Liver Channel.Preventing phlegm from forming and stopping coughing, soothing the liver circulation of qi promoting.Cure mainly cough with copious phlegm, hernia, scrofula, edema.
FLOS MUME: micro-acid, puckery, flat, returns liver, stomach, lung meridian.Dispersing the stagnated live-QI to relieve the stagnation of QI, and in, reduce phlegm.Cure mainly stomachache due to hyperactive liver-QI attacking the stomach, globus hystericus.
YIN-deficiency type post-cholecystectomy syndrome belongs to the category such as the traditional Chinese medical science " hypochondriac pain ", " feeling of fullness ".Before operation in patients, liver and gall are lost in catharsis, and bile keeps stasis, the life then of damp and hot turbid pathogen.After gallbladder removal, waste heat is unclear, weakness due to chronic disease in addition, the product of mistake bitter cold, and essence and blood loses, therefore produces a series of clinical symptoms.The present invention adopts Carapax Et Plastrum Testudinis, Fructus Elaeagni Angustifoliae, Fructus Mahoniae liver-nourishing kidney-boosting; Semen Podocarpi Macrophylli, Radix seu Caulis Embeliae Parviflorae nourish liver blood; Soil Iuba Equi, Folium Mahoniae rush down waste heat clearly; Circulation of qi promoting that Radix Eriobotryae, FLOS MUME are soothing the liver, and anti-all medicine bitter colds injure one's stomach.All medicines share, nourishing YIN and benefiting blood, Shugan Qingre, and hit pathogenesis.
Preferably, the Chinese medicine composition of described treatment YIN-deficiency type post-cholecystectomy syndrome is made up of the crude drug of following mass ratio:
Carapax Et Plastrum Testudinis 18 ~ 22 parts, 23 ~ 27 parts, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 7 ~ 9 parts, Semen Podocarpi Macrophylli 13 ~ 17 parts, Radix seu Caulis Embeliae Parviflorae 23 ~ 27 parts, 18 ~ 22 parts, native Iuba Equi, Folium Mahoniae 7 ~ 9 parts, Radix Eriobotryae 11 ~ 13 parts, FLOS MUME 3 ~ 5 parts.
Preferred further, the Chinese medicine composition of described treatment YIN-deficiency type post-cholecystectomy syndrome is made up of the crude drug of following mass ratio:
Carapax Et Plastrum Testudinis 20 parts, 25 parts, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 8 parts, Semen Podocarpi Macrophylli 15 parts, Radix seu Caulis Embeliae Parviflorae 25 parts, 20 parts, native Iuba Equi, Folium Mahoniae 8 parts, Radix Eriobotryae 12 parts, FLOS MUME 4 parts.
The Chinese medicine composition of described treatment YIN-deficiency type post-cholecystectomy syndrome can adopt existing Chinese medicine preparation technology to be prepared into any conventional oral preparations, such as can decocting be adopted to obtain water decoction said components, by other existing Chinese medicine preparation technology, the Chinese medicine composition of described treatment YIN-deficiency type post-cholecystectomy syndrome can also be prepared into tablet, water-honeyed pill, capsule, powder, unguentum, oral liquid, granule.
compared with prior art, beneficial effect of the present invention
The Chinese medicine composition for the treatment of YIN-deficiency type post-cholecystectomy syndrome provided by the invention, treatment YIN-deficiency type post-cholecystectomy syndrome have letter, just, honest and clean, the advantage such as to test.
treat a Chinese medicine composition for YIN-deficiency type post-cholecystectomy syndrome, clinical efficacy is summed up
1 physical data
In 40 routine patients, male 13 example, women 27 example; Minimum 31 years old of age, maximum 80 years old, 63.2 years old mean age.
2 diagnostic criterias
2.1 diagnostic criterias: with reference to " practical traditional Chinese medical science disease for digest " (Li Qian structure, Zhou Xuewen, SHAN Zhao wei. practical traditional Chinese medical science disease for digest. Beijing: People's Health Publisher, 2001.797-813) diagnostic criteria: 1. more than postcholecystectomy March; 2. postoperatively repeatedly there is right upper quadrant of the abdomen or side of body pain or vexed swollen sense of discomfort; 3. postoperatively repeatedly there is anorexia, detest greasy, abdominal distention, feel sick, borborygmus, the indigestion symptom such as diarrhoea or constipation; 4. Peptic Ulcers, gastroenteritis, hepatitis, pancreatitis has been got rid of before and after onset; 5. postoperative B ultrasonic, CT do not find choledocholithiasis or stenosis of bile duct person.Indispensable above 1. 4. 5. item, having 2. 3. item parts or symptomatology person concurrently can make a definite diagnosis.
2.2 tcm syndrome classification: with reference to " clinical Chinese Internal Medicine " (Wang Yongyan, Zhang Tian, Li Dichen. clinical Chinese Internal Medicine. Beijing: Beijing Publishing House, 1994.911-912) syndrome-classification standard: YIN-deficiency type: hypochondriac pain is indistinct, xerostomia, dry stool, yellowish urine is few, dysphoria with feverish sensation in the chest palms and soles, dizzy insomnia, red tongue no fur, thready and rapid pulse.
3 Therapeutic Method
Carapax Et Plastrum Testudinis 20 grams, 25 grams, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 8 grams, Semen Podocarpi Macrophylli 15 grams, Radix seu Caulis Embeliae Parviflorae 25 grams, 20 grams, native Iuba Equi, Folium Mahoniae 8 grams, Radix Eriobotryae 12 grams, FLOS MUME 4 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
4 therapeutic outcomes
4.1 efficacy assessment standards: reference " practical combination of Chinese and Western medicine internal medicine " (CHEN Ke ji. practical combination of Chinese and Western medicine internal medicine. Beijing: Beijing Medical University, combined publication society of China Concord Medical Science University, 1998.793) efficacy assessment standard: 1. cure: symptom, sign disappear; 2. effective: symptom, sign obviously alleviate or mostly disappear; 3. effective: symptom, sign alleviate; 4. invalid: symptom still exists, or exacerbation of symptoms, or choledocholithiasis recurrence.
4.2 results: through treatment in 4 weeks, cure 20 examples, effective 13 examples, effective 5 examples, invalid 2 examples, total effective rate 95.0%.
5 model cases
Ma, female, 38 years old.Patient to move ahead April cholecystectomy because of cholelithiasis.Existing patient's hypochondriac pain is indistinct, xerostomia, dry stool, dysphoria with feverish sensation in the chest palms and soles, dizzy insomnia, red tongue, no fur, thready pulse.Diagnosis: post-cholecystectomy syndrome (YIN-deficiency type).Take Chinese medicine composition water decoction provided by the invention treatment 4 weeks, symptom and sign disappears.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
A kind of Chinese medicine composition for the treatment of YIN-deficiency type post-cholecystectomy syndrome, by Carapax Et Plastrum Testudinis 25 grams, 30 grams, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 10 grams, Semen Podocarpi Macrophylli 20 grams, Radix seu Caulis Embeliae Parviflorae 30 grams, 25 grams, native Iuba Equi, Folium Mahoniae 10 grams, Radix Eriobotryae 15 grams, FLOS MUME 5 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 2
A kind of Chinese medicine composition for the treatment of YIN-deficiency type post-cholecystectomy syndrome, by Carapax Et Plastrum Testudinis 22 grams, 27 grams, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 9 grams, Semen Podocarpi Macrophylli 17 grams, Radix seu Caulis Embeliae Parviflorae 27 grams, 22 grams, native Iuba Equi, Folium Mahoniae 9 grams, Radix Eriobotryae 13 grams, FLOS MUME 5 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 3
A kind of Chinese medicine composition for the treatment of YIN-deficiency type post-cholecystectomy syndrome, by Carapax Et Plastrum Testudinis 20 grams, 25 grams, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 8 grams, Semen Podocarpi Macrophylli 15 grams, Radix seu Caulis Embeliae Parviflorae 25 grams, 20 grams, native Iuba Equi, Folium Mahoniae 8 grams, Radix Eriobotryae 12 grams, FLOS MUME 4 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 4
A kind of Chinese medicine composition for the treatment of YIN-deficiency type post-cholecystectomy syndrome, by Carapax Et Plastrum Testudinis 18 grams, 23 grams, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 7 grams, Semen Podocarpi Macrophylli 13 grams, Radix seu Caulis Embeliae Parviflorae 23 grams, 18 grams, native Iuba Equi, Folium Mahoniae 7 grams, Radix Eriobotryae 11 grams, FLOS MUME 3 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 5
A kind of Chinese medicine composition for the treatment of YIN-deficiency type post-cholecystectomy syndrome, by Carapax Et Plastrum Testudinis 15 grams, 20 grams, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 6 grams, Semen Podocarpi Macrophylli 10 grams, Radix seu Caulis Embeliae Parviflorae 20 grams, 15 grams, native Iuba Equi, Folium Mahoniae 6 grams, Radix Eriobotryae 9 grams, FLOS MUME 3 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Claims (4)
1. treat a Chinese medicine composition for YIN-deficiency type post-cholecystectomy syndrome, it is characterized in that being made up of the crude drug of following mass ratio:
Carapax Et Plastrum Testudinis 15 ~ 25 parts, 20 ~ 30 parts, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 6 ~ 10 parts, Semen Podocarpi Macrophylli 10 ~ 20 parts, Radix seu Caulis Embeliae Parviflorae 20 ~ 30 parts, 15 ~ 25 parts, native Iuba Equi, Folium Mahoniae 6 ~ 10 parts, Radix Eriobotryae 9 ~ 15 parts, FLOS MUME 3 ~ 5 parts.
2. the Chinese medicine composition for the treatment of YIN-deficiency type post-cholecystectomy syndrome as claimed in claim 1, is characterized in that being made up of the crude drug of following mass ratio:
Carapax Et Plastrum Testudinis 18 ~ 22 parts, 23 ~ 27 parts, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 7 ~ 9 parts, Semen Podocarpi Macrophylli 13 ~ 17 parts, Radix seu Caulis Embeliae Parviflorae 23 ~ 27 parts, 18 ~ 22 parts, native Iuba Equi, Folium Mahoniae 7 ~ 9 parts, Radix Eriobotryae 11 ~ 13 parts, FLOS MUME 3 ~ 5 parts.
3. the Chinese medicine composition for the treatment of YIN-deficiency type post-cholecystectomy syndrome as claimed in claim 1, is characterized in that being made up of the crude drug of following mass ratio:
Carapax Et Plastrum Testudinis 20 parts, 25 parts, Fructus Elaeagni Angustifoliae, Fructus Mahoniae 8 parts, Semen Podocarpi Macrophylli 15 parts, Radix seu Caulis Embeliae Parviflorae 25 parts, 20 parts, native Iuba Equi, Folium Mahoniae 8 parts, Radix Eriobotryae 12 parts, FLOS MUME 4 parts.
4. treat the preparation method of the Chinese medicine composition of YIN-deficiency type post-cholecystectomy syndrome as claimed in claim 1, it is characterized in that the Chinese medicinal components of described mass ratio to be prepared into water decoction, tablet, water-honeyed pill, capsule, powder, unguentum, oral liquid, granule.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510443422.0A CN105012435A (en) | 2015-07-27 | 2015-07-27 | Traditional Chinese medicine composition treating yin-deficiency type postcholecystectomy syndrome |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510443422.0A CN105012435A (en) | 2015-07-27 | 2015-07-27 | Traditional Chinese medicine composition treating yin-deficiency type postcholecystectomy syndrome |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105012435A true CN105012435A (en) | 2015-11-04 |
Family
ID=54402980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510443422.0A Pending CN105012435A (en) | 2015-07-27 | 2015-07-27 | Traditional Chinese medicine composition treating yin-deficiency type postcholecystectomy syndrome |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105012435A (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104189759A (en) * | 2014-09-03 | 2014-12-10 | 商西丹 | Traditional Chinese medicine composition for treating cholelithiasis |
CN104383253A (en) * | 2014-12-01 | 2015-03-04 | 孙爱华 | Method for extracting turtle and deer antler capsule and new use of turtle and deer antler capsule |
CN104436070A (en) * | 2014-12-22 | 2015-03-25 | 姜兆明 | Medicine for treating chronic cholecystitis and preparation method of medicine |
CN104771513A (en) * | 2015-04-22 | 2015-07-15 | 王玉玲 | Traditional Chinese medicine composition for treating cholecystitis |
-
2015
- 2015-07-27 CN CN201510443422.0A patent/CN105012435A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104189759A (en) * | 2014-09-03 | 2014-12-10 | 商西丹 | Traditional Chinese medicine composition for treating cholelithiasis |
CN104383253A (en) * | 2014-12-01 | 2015-03-04 | 孙爱华 | Method for extracting turtle and deer antler capsule and new use of turtle and deer antler capsule |
CN104436070A (en) * | 2014-12-22 | 2015-03-25 | 姜兆明 | Medicine for treating chronic cholecystitis and preparation method of medicine |
CN104771513A (en) * | 2015-04-22 | 2015-07-15 | 王玉玲 | Traditional Chinese medicine composition for treating cholecystitis |
Non-Patent Citations (1)
Title |
---|
张静 孙宏亮主编: "《中医辨证施治消化系统疑难病》", 31 January 2007, 科学技术文献出版社 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103550517B (en) | A kind of medicine of Hepatoma therapy | |
CN104399009A (en) | Traditional Chinese medicine formula for treating liver cancer and preparation method adopting traditional Chinese medicine formula | |
CN103341127A (en) | Traditional Chinese medicine for treating uremia along with hematodialysis and preparation method | |
CN103908511B (en) | One treats chondromatous Chinese medicinal pill and preparation method | |
CN106266999A (en) | A kind of Chinese medicine composition treating irritability and palpitation and insomnia and preparation method thereof | |
CN103638234B (en) | A kind of Chinese medicine composition, preparation and preparation method thereof for the treatment of tinnitus | |
CN103330837B (en) | Traditional Chinese medicine composition for curing osteoporosis of menopausal women | |
CN104721758A (en) | Pharmaceutical for treating ovarian cyst and preparing method thereof | |
CN104548049A (en) | Traditional Chinese medicine composition for treating senile osteoporosis and preparation method thereof | |
CN104784538A (en) | Chinese medicinal preparation for treating diabetes and preparation method | |
CN102671169A (en) | Traditional Chinese medicine for treating acute pelvic inflammatory disease and preparation method | |
CN102178866A (en) | Chinese medicinal preparation for dispelling damp, promoting blood circulation, softening hard mass and eliminating stagnation for people with qi-depression and blood-stagnation physique, preparation method thereof and application thereof | |
CN105213589A (en) | A kind of Chinese medicine formula for the treatment of rheumatoid arthritis | |
CN104606661A (en) | Traditional Chinese medicinal galactagogue for treating hypogalactia after cesarean delivery and preparation method of galactagogue | |
CN104922499A (en) | Traditional Chinese medicine for treating hepatitis | |
CN104888104A (en) | Pharmaceutical composition for nursing and treating varicose veins and preparation method of pharmaceutical composition | |
CN104547553A (en) | Traditional Chinese medicine for treating nervous endocrine disorder | |
CN105727163A (en) | A traditional Chinese medicine formula for treating liver cancer and a preparing method thereof | |
CN103893432A (en) | Pharmaceutical composition for treating fracture and soft tissue injury and preparation method of pharmaceutical composition | |
CN105012435A (en) | Traditional Chinese medicine composition treating yin-deficiency type postcholecystectomy syndrome | |
CN101869629B (en) | Traditional Chinese medicine for treating renal calculus | |
CN105194588A (en) | Traditional Chinese medicine preparation for treating liver cirrhosis | |
CN105168944A (en) | Traditional Chinese medicinal composition for treating breast cancer and application thereof | |
CN104524463B (en) | A kind of pharmaceutical composition for treating acne | |
CN104800688A (en) | Traditional Chinese medicine composition for treating chronic nephritis and application |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151104 |