CN105012337A - 一种用于治疗关节炎的吸入式药物组合物及其制备方法 - Google Patents
一种用于治疗关节炎的吸入式药物组合物及其制备方法 Download PDFInfo
- Publication number
- CN105012337A CN105012337A CN201410337830.3A CN201410337830A CN105012337A CN 105012337 A CN105012337 A CN 105012337A CN 201410337830 A CN201410337830 A CN 201410337830A CN 105012337 A CN105012337 A CN 105012337A
- Authority
- CN
- China
- Prior art keywords
- inhaling
- medicinal compositions
- gas
- hydrogen
- type medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 31
- 206010003246 arthritis Diseases 0.000 title abstract description 8
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract description 96
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 96
- 239000007789 gas Substances 0.000 claims abstract description 92
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 87
- 239000007788 liquid Substances 0.000 claims abstract description 66
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims abstract description 49
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229960000590 celecoxib Drugs 0.000 claims abstract description 25
- 229960002390 flurbiprofen Drugs 0.000 claims abstract description 25
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229960000905 indomethacin Drugs 0.000 claims abstract description 25
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 9
- 239000000203 mixture Substances 0.000 claims description 141
- 230000002917 arthritic effect Effects 0.000 claims description 46
- 239000011800 void material Substances 0.000 claims description 43
- 238000000889 atomisation Methods 0.000 claims description 41
- 238000005868 electrolysis reaction Methods 0.000 claims description 35
- 239000001301 oxygen Substances 0.000 claims description 31
- 229910052760 oxygen Inorganic materials 0.000 claims description 31
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 30
- 239000012267 brine Substances 0.000 claims description 18
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 claims description 18
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 8
- 229910001882 dioxygen Inorganic materials 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 229910052756 noble gas Inorganic materials 0.000 claims description 5
- 239000003814 drug Substances 0.000 abstract description 21
- 230000000694 effects Effects 0.000 abstract description 11
- 229940079593 drug Drugs 0.000 abstract description 8
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 230000003211 malignant effect Effects 0.000 abstract 1
- 238000010586 diagram Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 7
- 230000000202 analgesic effect Effects 0.000 description 6
- 230000003110 anti-inflammatory effect Effects 0.000 description 6
- 150000003254 radicals Chemical class 0.000 description 5
- 230000003637 steroidlike Effects 0.000 description 5
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 description 4
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 201000008482 osteoarthritis Diseases 0.000 description 3
- 230000000505 pernicious effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 206010044412 transitional cell carcinoma Diseases 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 108010037462 Cyclooxygenase 2 Proteins 0.000 description 1
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 108010017796 epoxidase Proteins 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
- A61M16/101—Preparation of respiratory gases or vapours with O2 features or with parameter measurement using an oxygen concentrator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
- A61M16/16—Devices to humidify the respiration air
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0208—Oxygen
Abstract
本发明提供一种用于治疗关节炎的吸入式药物组合物及其制备方法,包含第一气体及雾化药液。第一气体包含氢气,氢气占吸入式药物组合物的气体体积浓度在2%~96%之间。雾化药液包含选自吲哚美辛、氟联苯丙酸以及塞来昔布所组成的组中之一或其组合。本发明的吸入式药物组合物除了可以通过氢气去除患者体内的恶性自由基,并通过雾化药液以增加患者的药物吸收疗效,也因为使用少量雾化药液剂量,间接地降低药剂对人体产生的副作用。
Description
技术领域
本发明涉及一种吸入式药物组合物及其制备方法,特别涉及一种用于治疗关节炎的吸入式药物组合物及其制备方法。
背景技术
关节炎(Arthritis)包括退化性关节炎(Degenerative Joint Disease,DJD)、类风湿性关节炎(Rheumatoid Arthritis,RA)及其他关节病症。已知关节炎病症的特征为发炎和疼痛,且大多数关节炎病症为持续性地恶化。
临床上在治疗关节炎患者时通常使用的药物包括非类固醇消炎止痛药(Nonsteroidal Anti-Inflammatory Drugs,NSAIDs),以减轻关节炎患者的疼痛。由于当人体受到伤害时,环氧化酶-2(Cyclo-Oxygenase-2,COX-2)便会表现而引发发炎反应,因此通过非类固醇消炎止痛药可以用来抑制环氧化酶-2(COX-2)的活性,以减轻炎性反应。非类固醇消炎止痛药通常可分为非选择性药物,如吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen);及环氧化酶-2(COX-2)的选择性药物,如塞来昔布(Celecoxib)。
然而,由于非类固醇消炎止痛药在结构上都属于弱酸对于消化道刺激较强,同时由于非类固醇消炎止痛药在抑制环氧酶的作用下进而会降低前列腺素对消化道粘膜的保护作用,因此,非类固醇消炎止痛药主要存在的副作用为胃肠道障碍(如对胃肠道刺激,诱发胃溃疡等)。
如上所述,因此目前缺乏一种能兼具治疗效果且降低对患者产生副作用的关节炎药剂。
发明内容
因此,本发明提供一种用于治疗关节炎的吸入式药物组合物,包含第一气体及雾化药液。第一气体包含氢气,氢气占吸入式药物组合物的气体体积浓度在2%~96%之间。雾化药液包含选自吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen)以及塞来昔布(Celecoxib)所组成的组中之一或其组合。
根据本发明的一实施例提供一种用于治疗关节炎的吸入式药物组合物,第一气体是由电解水所产生的氢氧混合气体,其中氢气与氧气的体积比约为2:1。于一实施例中,氢气占吸入式药物组合物的气体体积浓度在2%~66.66%之间。此外,本发明吸入式药物组合物还包含第二气体,用于降低吸入式药物组合物中氢气的气体体积浓度,其中第二气体为选自由空气、水蒸汽、惰性气体、氧气及其组合所组成的组中的一种气体。于另一实施例中,氢气占吸入式药物组合物的气体体积浓度在4.7%~66.66%之间。
根据本发明的另一实施例提供一种用于治疗关节炎的吸入式药物组合物,氢气占吸入式药物组合物的气体体积浓度在60%~66.66%之间。此外,于另一实施例提供一种用于治疗关节炎的吸入式药物组合物,氢气占吸入式药物组合物的气体体积浓度大于66.66%。
此外,本发明还提供一种用于治疗关节炎的吸入式药物组合物的制备方法,包含下列步骤:
(S1)制备第一气体,第一气体包含氢气;
(S2)雾化一药液以产生雾化药液,药液包含选自吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen)以及塞来昔布(Celecoxib)所组成的组中之一或其组合;以及
(S3)混合第一气体以及雾化药液以产生该吸入式药物组合物,其中氢气占吸入式药物组合物的气体体积浓度在2%~96%之间。
根据本发明的一实施例提供一种用于治疗关节炎的吸入式药物组合物的制备方法,本发明方法的步骤(S1)为电解水以产生第一气体,第一气体含氢氧混合气体,其中氢气与氧气的体积比约为2:1。
根据本发明的另一实施例提供一种用于治疗关节炎的吸入式药物组合物的制备方法,本发明方法的步骤包含:
(S21)制备第一气体,第一气体包含氢气;
(S22)雾化一药液以产生雾化药液,药液包含选自吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen)以及塞来昔布(Celecoxib)所组成的组中之一或其组合;
(S23)准备第二气体;以及
(S24)混合第一气体、第二气体以及雾化药液以产生吸入式药物组合物,其中第二气体用于降低吸入式药物组合物中氢气的气体体积浓度。于此实施例中,本发明用于治疗关节炎的吸入式药物组合物中氢气占吸入式药物组合物的气体体积浓度,可因第二气体加入而降低吸入式药物组合物中氢气的气体体积浓度。
此外,根据本发明的另一实施例提供一种用于治疗关节炎的吸入式药物组合物的制备方法,其中氢气占吸入式药物组合物的气体体积浓度在60%~66.66%之间。于另一实施例提供一种用于治疗关节炎的吸入式药物组合物的制备方法,其中氢气占吸入式药物组合物的气体体积浓度大于66.66%。
相比于现有技术,本发明提供一种用于治疗关节炎的吸入式药物组合物及其制备方法,本发明吸入式药物组合物除了可以提供患者直接吸入的服用便利性外,并可以通过氢气以去除患者体内的恶性自由基,并通过雾化药液以增加患者的药物吸收疗效。
附图说明
图1是本发明用于治疗关节炎的吸入式药物组合物的制备方法于一具体实施例的方法流程图。
图2是本发明用于治疗关节炎的吸入式药物组合物的制备方法于另一具体实施例的方法流程图。
图3是本发明用于治疗关节炎的吸入式药物组合物的制备方法中步骤(S1)于一具体实施例的电解装置示意图。
图4是本发明用于治疗关节炎的吸入式药物组合物的制备方法中步骤(S2)及(S3)于一具体实施例的气体混合系统示意图。
具体实施方式
为了让本发明的优点,精神与特征可以更容易且明确地了解,后续将以实施例并参照所附附图进行详述与讨论。值得注意的是,这些实施例仅为本发明代表性的实施例,其中所举例的特定方法、装置、条件、材质等并非用以限定本发明或对应的实施例。
本发明提出一种用于治疗关节炎的吸入式药物组合物,其包含第一气体及雾化药液。第一气体包含氢气,氢气占吸入式药物组合物的气体体积浓度在2%~96%之间。雾化药液包含选自吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen)以及塞来昔布(Celecoxib)所组成的组中之一或其组合。
于本发明的实施例中,第一气体还包含氧气,而第一气体是由电解水所产生的氢氧混合气体,其中氢气与氧气的体积比约为2:1。于实际应用时,氢气与氧气的体积比原则是2:1,但是有时在收集电极的氢气或氧气会有些许误差,但仍约为2:1。而雾化药液则是由针对一药液进行雾化或挥发所产生,其中药液包含选自吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen)以及塞来昔布(Celecoxib)所组成的组中之一或其组合,且上述药物应用于关节炎治疗上已为本领域的技术人员所熟知,故在此不多加赘述。于本实施例中,氢气占吸入式药物组合物的气体体积浓度在2%~66.66%之间。
本发明吸入式药物组合物还包含第二气体,第二气体用于降低吸入式药物组合物中氢气的气体体积浓度,其中第二气体为选自由空气、水蒸汽、惰性气体、氧气及其组合所组成的组中的一种气体。于本实施例中,氢气占吸入式药物组合物的气体体积浓度可在4.7%~66.66%之间,惟不以此范围为限。
于另一具体实施例中,本发明吸入式药物组合物可以通过混合第一气体以及雾化一体积为40c.c.的药液所产生的雾化药液所制备,而氢气占吸入式药物组合物的气体体积浓度在60%~66.66%之间。于另一实施例中,也可以用氢气瓶提供所需氢气,并与雾化药液进行混合,此时氢气占吸入式药物组合物的气体体积浓度将可能会高于66.66%,例如67%~96%之间。于另一实施例中,也可直接收集电解水中所产生的氢气(而非氢氧混合气)直接与雾化药液进行混合,此时氢气占吸入式药物组合物的气体体积浓度将也会高于66.66%。
请参阅图1,图1是本发明用于治疗关节炎的吸入式药物组合物的制备方法于一具体实施例的方法流程图。如图所示,本发明吸入式药物组合物的制备方法包含下列步骤:
(S1)制备第一气体,第一气体包含有氢气;
(S2)雾化一药液以产生雾化药液,药液包含有选自吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen)以及塞来昔布(Celecoxib)所组成的组中之一或其组合;以及
(S3)混合第一气体以及雾化药液以产生吸入式药物组合物,其中氢气占吸入式药物组合物的气体体积浓度在2%~96%之间。
根据本发明的一实施例提供一种用于治疗关节炎的吸入式药物组合物的制备方法,本发明方法的步骤(S1)为电解水以产生第一气体,第一气体含氢氧混合气体,其中氢气与氧气的体积比约为2:1。于实际应用时,氢气与氧气的体积比原则是2:1,但是有时在收集电极的氢气或氧气会有些许误差,但仍约为2:1。于一实施例中,氢气占吸入式药物组合物的气体体积浓度在2%~66.66%之间,惟不以此范围为限。
请参阅图2,图2是本发明用于治疗关节炎的吸入式药物组合物的制备方法于另一具体实施例的方法流程图。如图所示,本发明吸入式药物组合物的另一制备方法,包含下列步骤:
(S21)制备第一气体,第一气体包含有氢气;
(S22)雾化一药液以产生雾化药液,药液包含有选自吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen)以及塞来昔布(Celecoxib)所组成的组中之一或其组合;以及
(S23)准备第二气体;以及
(S24)混合第一气体、第二气体以及雾化药液以产生吸入式药物组合物。
根据本发明的一实施例提供一种用于治疗关节炎的吸入式药物组合物的制备方法,本发明方法的步骤(S21)为电解水以产生第一气体,第一气体含氢氧混合气体,其中氢气与氧气的体积比约为2:1。于实际应用时,氢气与氧气的体积比原则是2:1,但是有时在收集电极的氢气或氧气会有些许误差,但仍约为2:1。此外,本发明用于治疗关节炎的吸入式药物组合物中氢气占吸入式药物组合物的气体体积浓度,可因第二气体加入而降低吸入式药物组合物中氢气的气体体积浓度,于本实施例中,氢气占吸入式药物组合物的气体体积浓度可在4.7%~66.66%之间,惟不以此范围为限。
当然,于另一实施例中,也可以用氢气瓶提供所需氢气,并与雾化药液进行混合,此时氢气占吸入式药物组合物的气体体积浓度将可能会高于66.66%,例如67%~96%之间。但因吸入气体中氢气体积浓度太高(如高于96%)可能使氧气体积浓度太低而对人体产生缺氧的不良影响,因此此时需注意控制氢气体积浓度不要高于96%,如在67%~90%之间。于另一实施例中,也可直接收集电解水中所产生的氢气(而非氢氧混合气)直接与雾化药液进行混合,此时氢气占吸入式药物组合物的气体体积浓度将也会高于66.66%。
请参阅图3,图3是本发明的用于治疗关节炎的吸入式药物组合物的制备方法中步骤(S1)于一具体实施例的电解装置示意图。于本实施例中,本发明能够通过电解水以产生含有氢氧混合气体的第一气体,其中电解装置100包含电解槽102、电解水104、电极106A、106B以及电源。
首先,电解槽102用于容纳电解水104,其中电解水104主要成份为纯水,惟不以此为限,于实际应用时,电解水能够视需要以添加少量的电解质,如氢氧化钠、碳酸钙、氯化钠等。再者,电解槽102中包含电极106A、106B,电极106A、106B分别为一阴极电极及一阳极电极,并耦接至一电源(未绘示于图中),以提供电解水所需的电能。于一具体实施例中,电极106A、106B能够是固定的极性,如电极106A为阴极,电极106B为阳极,惟电极的极性不以固定为限。于另一具体实施例中,电极106A、106B能够是交替变换的极性,如在某一时间点,电极106A为阴极,电极106B为阳极;经过一预定时间后,在另一时间点,电极106A切换为阳极,电极106B切换为阴极,其后依此类推。
接着,电解槽102中的电解水104经过电极106A、106B通电后会开始电解,而在阴极(负极)产生氢气,阳极(正极)产生氧气,且释出于电解槽102的上部,以形成一第一气体108,其中第一气体108由电解槽102的第一气体管路110输出,以作为后续的使用,惟不以此为限。于另一个实施例中,本发明亦能够将阴极产生的氢气与阳极产生的氧气,分别以一气体导管导引出电解槽102,之后再进行混合而产生第一气体108。
由于电解水104经过电解后所产生的氢气及氧气的体积比约为2:1。于一具体实施例中,本发明能够再添加第二气体112,以降低吸入式药物组合物中氢气的气体体积浓度,例如氢气占吸入式药物组合物的气体体积浓度可以控制在4.7%~66.66%之间,其中第二气体为选自由空气、水蒸汽、惰性气体、氧气及其组合所组成的组中的一种气体。
请参阅图4,图4是本发明用于治疗关节炎的吸入式药物组合物的制备方法中步骤(S2)及(S3)于一具体实施例的气体混合系统的示意图。本发明吸入式药物组合物的制备方法中步骤(S2)及(S3)可以通过气体混合系统200,以雾化药液220并混合第一气体108进而产生吸入式药物组合物214。
气体混合系统200包含一雾化/挥发气体混合槽210,雾化/挥发气体混合槽210由第一气体管路110与电解装置100(如图3所示)耦接,以接收第一气体108,并与雾化药液212混合,以形成吸入式药物组合物214。雾化/挥发气体混合槽210还包括一震荡器216(例如超音波震荡器),适于对雾化/挥发气体混合槽210中药液220进行雾化,以产生雾化药液212。药液220可以为吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen)以及塞来昔布(Celecoxib)所组成的组中之一或其组合,且上述药物应用于关节炎治疗上已为本领域的技术人员所熟知,故在此不多加赘述。
于另一具体实施例中,雾化/挥发气体混合槽210中可容纳的药液约40~100c.c范围,预估以60分钟内雾化完毕,故雾化药液本身产气量约0.67cc/min~1.67cc/min之间,而电解槽102控制每分钟产气量约2,000cc/min~3,000cc/min之间,其中如电解槽产气结果仅仅是氢氧混合气(氢气及氧气的体积比约为2:1),则氢气占吸入式药物组合物的气体体积浓度在66.61%~66.65%之间。但有时因电解槽电解的热能,会蒸发电解水而使电解槽产气结果除氢氧混合气外,还可能含有少量些许的水蒸气,因此氢气占吸入式药物组合物的气体体积浓度会低于66.61%,例如在60%~66.61%之间,当然上述的少量些许水蒸气可以通过降温而减少。本发明吸入式药物组合物的制备方法可以通过混合氢氧混合气以及雾化药液所制备,一般而言氢气占吸入式药物组合物的气体体积浓度在60%~66.66%之间。
于另一具体实施例中,第一气体及雾化药液在吸入式药物组合物中的组成含量比例依气体体积百分比浓度计得分别为35.33~99.99%及0.01~64.67%,但并不以此比例为限,于实际应用时,第一气体、雾化药液在吸入式药物组合物中的组成含量比例得视病人情况进行调整。于实际应用时,本发明的吸入式药物组合物得通过吸入并每天施用至少30~60分钟,每天为一次至三次。
此外,于另一具体实施例中,第一气体、雾化药液及第二气体在吸入式药物组合物中的组成含量比例依气体体积百分比浓度计得分别为33~97%、0.01~64%及2~66%,但并不以此比例为限,于实际应用时,第一气体、雾化药液及第二气体在吸入式药物组合物中的组成含量比例得视病人情况进行调整。于实际应用时,本发明的吸入式药物组合物得通过吸入并每天施用至少30~60分钟,每天为一次至三次。
由上述实施例可知,本发明吸入式药物组合物包含氢气与雾化药液,以提供患者(未绘示)吸入。人体因各种原因,(比如疾病、饮食、所处环境或生活习惯)引生的恶性自由基,亦称有害自由基,可以与吸入的氢气还原成部份的水,而排出体外。间接减少人体自由基的数量,达到酸性体质还原至健康的碱性体质,可以抗氧化进而也达到消除慢性疾病效果。另外,液态药液于一实施例中经过雾化后形成1~5微米的药水粒子,经由吸入的方式,而透过鼻粘膜或肺泡直接吸收,可以更有利于人体吸收,也就是说较少雾化药液剂量即可达到原先一般口服或注射所需要药剂量的治疗效果,也因为使用少量雾化药液剂量,也间接降低药剂对人体产生的副作用。当然药液也可以是口服药溶于水后的混合液。因此,本发明通过具有氢氧与雾化药液的吸入式药物组合物,供人体吸入后可以达到更好的治疗或医疗效果。
相比于现有技术,本发明提供一种用于治疗关节炎的吸入式药物组合物及其制备方法,本发明吸入式药物组合物除了可以通过氢气以去除患者体内的恶性自由基,并通过雾化药液以增加患者的药物吸收疗效,通过较少雾化药液剂量即可达到原先一般口服或注射所需要药剂量的治疗效果,因而能使用少量雾化药液剂量,间接地降低药剂对人体产生的副作用。
通过以上较佳具体实施例的详述,希望能更加清楚描述本发明的特征与精神,而并非以上述所揭露的较佳具体实施例来对本发明的范畴加以限制。相反地,其目的是希望能涵盖各种改变及具相等性的安排于本发明所欲申请的专利范围的范畴内。因此,本发明所申请的专利范围的范畴应根据上述的说明作最宽广的解释,以致使其涵盖所有可能的改变以及具相等性的安排。
Claims (20)
1.一种用于治疗关节炎的吸入式药物组合物,包含第一气体及雾化药液,其中该第一气体包含氢气,氢气占该吸入式药物组合物的气体体积浓度在2%~96%之间,该雾化药液包含选自吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen)以及塞来昔布(Celecoxib)所组成的组中之一或其组合。
2.如权利要求1所述的用于治疗关节炎的吸入式药物组合物,其特征在于,该第一气体还包含氧气。
3.如权利要求2所述的用于治疗关节炎的吸入式药物组合物,其特征在于,该第一气体是由电解水所产生的氢氧混合气体,其中氢气与氧气的体积比约为2:1。
4.如权利要求2所述的用于治疗关节炎的吸入式药物组合物,其特征在于,还包含第二气体,用于降低该吸入式药物组合物中氢气的气体体积浓度,其中该第二气体为选自由空气、水蒸汽、惰性气体、氧气及其组合所组成的组中的一种气体。
5.如权利要求1所述的用于治疗关节炎的吸入式药物组合物,其特征在于,氢气占该吸入式药物组合物的气体体积浓度在2%~66.66%之间。
6.如权利要求1所述的用于治疗关节炎的吸入式药物组合物,其特征在于,氢气占该吸入式药物组合物的气体体积浓度在4.7%~66.66%之间。
7.如权利要求1所述的用于治疗关节炎的吸入式药物组合物,其特征在于,氢气占该吸入式药物组合物的气体体积浓度在60%~66.66%之间。
8.如权利要求1所述的用于治疗关节炎的吸入式药物组合物,其特征在于,氢气占该吸入式药物组合物的气体体积浓度大于66.66%。
9.如权利要求1所述的用于治疗关节炎的吸入式药物组合物,其特征在于,该雾化药液是由针对一药液进行雾化或挥发所产生。
10.如权利要求9所述的用于治疗关节炎的吸入式药物组合物,其特征在于,该药液包含选自吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen)以及塞来昔布(Celecoxib)所组成的组中之一或其组合。
11.一种用于治疗关节炎的吸入式药物组合物的制备方法,包含下列步骤:
(S1)制备第一气体,该第一气体包含氢气;
(S2)雾化一药液以产生雾化药液,该药液包含选自吲哚美辛(Indomethacin)、氟联苯丙酸(Flurbiprofen)以及塞来昔布(Celecoxib)所组成的组中之一或其组合;以及
(S3)混合该第一气体以及该雾化药液以产生该吸入式药物组合物,其中氢气占该吸入式药物组合物的气体体积浓度在2%~96%之间。
12.如权利要求11所述的用于治疗关节炎的吸入式药物组合物的制备方法,其特征在于,于步骤(S2)之后另包含下列步骤:
(S23)准备第二气体。
13.如权利要求12所述的用于治疗关节炎的吸入式药物组合物的制备方法,其特征在于,该步骤(S3)为混合该第一气体、该第二气体以及该雾化药液以产生该吸入式药物组合物。
14.如权利要求12所述的用于治疗关节炎的吸入式药物组合物的制备方法,其特征在于,该第二气体用于降低该吸入式药物组合物中氢气的气体体积浓度。
15.如权利要求12所述的用于治疗关节炎的吸入式药物组合物的制备方法,其特征在于,该第二气体为选自由空气、水蒸汽、惰性气体、氧气及其组合所组成的组中的一种气体。
16.如权利要求11所述的用于治疗关节炎的吸入式药物组合物的制备方法,其特征在于,步骤(S1)为电解水以产生该第一气体,该第一气体含氢氧混合气体,其中氢气与氧气的体积比约为2:1。
17.如权利要求11所述的用于治疗关节炎的吸入式药物组合物的制备方法,其特征在于,氢气占该吸入式药物组合物的气体体积浓度在2%~66.66%之间。
18.如权利要求11所述的用于治疗关节炎的吸入式药物组合物的制备方法,其特征在于,氢气占该吸入式药物组合物的气体体积浓度在4.7%~66.66%之间。
19.如权利要求11所述的用于治疗关节炎的吸入式药物组合物的制备方法,其特征在于,氢气占该吸入式药物组合物的气体体积浓度在60%~66.66%之间。
20.如权利要求11所述的用于治疗关节炎的吸入式药物组合物的制备方法,其特征在于,氢气占该吸入式药物组合物的气体体积浓度大于66.66%。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW103114135 | 2014-04-18 | ||
TW103114135A TWI586383B (zh) | 2014-04-18 | 2014-04-18 | 一種用於治療關節炎之吸入式醫藥組成物及其備製方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105012337A true CN105012337A (zh) | 2015-11-04 |
Family
ID=54250018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410337830.3A Pending CN105012337A (zh) | 2014-04-18 | 2014-07-16 | 一种用于治疗关节炎的吸入式药物组合物及其制备方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US9339456B2 (zh) |
JP (1) | JP2015205863A (zh) |
KR (1) | KR20150120851A (zh) |
CN (1) | CN105012337A (zh) |
DE (1) | DE102015104361B4 (zh) |
TW (1) | TWI586383B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109336816A (zh) * | 2018-09-29 | 2019-02-15 | 中国药科大学 | 一种塞来昔布吲哚美辛的共无定形物 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2564651B (en) * | 2017-07-17 | 2019-11-13 | Keymed Medical & Industrial Equipment Ltd | Medical gas supply system |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101287476A (zh) * | 2005-08-19 | 2008-10-15 | 太田成男 | 机体内的有害活性氧类和/或自由基清除剂 |
CN101553210A (zh) * | 2006-09-20 | 2009-10-07 | 奈克斯特安全有限公司 | 经吸入输送药物的方法和系统 |
CN203291353U (zh) * | 2013-06-19 | 2013-11-20 | 林信涌 | 保健气体产生器 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69229070T2 (de) * | 1991-02-09 | 1999-11-18 | B S D Bio Science Dev Snc Di O | Antireaktive antiasthmatische Wirkung von Acetylsalicylsäure durch Inhalation |
DE19734279A1 (de) * | 1997-08-07 | 1999-02-11 | Messer Griesheim Gmbh | Wasserstoffhaltiges Medikament |
FR2812545B1 (fr) * | 2000-08-03 | 2003-03-28 | Air Liquide Sante Int | Aerosol medicamenteux inhalable dans le traitement ou la prevention de la douceur |
DE60230609D1 (de) | 2001-05-24 | 2009-02-12 | Alexza Pharmaceuticals Inc | Verabreichung von nichtsteroidalen entzündungshemmenden wirkstoffen durch inhalation |
ITMI20050417A1 (it) * | 2005-03-15 | 2006-09-16 | Medestea Res & Production S R L | Uso di farmaci anti-infiammatori non steroidei per via inalatoria nella terapia della bronchite acuta e cronica |
JP5106110B2 (ja) * | 2005-08-19 | 2012-12-26 | 成男 太田 | 生体内の有害な活性酸素及び/又はフリーラジカル除去剤 |
EP2608829A4 (en) | 2010-08-23 | 2015-11-18 | Darren Rubin | SYSTEMS AND METHODS FOR AEROSOL SUPPLY WITH AIRFLOW REGULATION |
TWI602585B (zh) * | 2014-03-25 | 2017-10-21 | 林信湧 | 一種用於治療阿茲海默症之吸入式醫藥組成物及其備製方法 |
TWI590837B (zh) * | 2014-03-25 | 2017-07-11 | 林信湧 | 一種用於治療心臟病之吸入式醫藥組成物及其備製方法 |
TWI589308B (zh) * | 2014-03-25 | 2017-07-01 | 林信湧 | 一種用於治療帕金森氏症之吸入式醫藥組成物及其備製方法 |
TWI569816B (zh) * | 2014-04-18 | 2017-02-11 | 林信湧 | 一種用於治療痛風之吸入式醫藥組成物及其備製方法 |
-
2014
- 2014-04-18 TW TW103114135A patent/TWI586383B/zh active
- 2014-07-16 CN CN201410337830.3A patent/CN105012337A/zh active Pending
-
2015
- 2015-03-20 US US14/664,508 patent/US9339456B2/en active Active
- 2015-03-24 JP JP2015060838A patent/JP2015205863A/ja active Pending
- 2015-03-24 DE DE102015104361.0A patent/DE102015104361B4/de not_active Expired - Fee Related
- 2015-03-25 KR KR1020150041758A patent/KR20150120851A/ko not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101287476A (zh) * | 2005-08-19 | 2008-10-15 | 太田成男 | 机体内的有害活性氧类和/或自由基清除剂 |
CN101553210A (zh) * | 2006-09-20 | 2009-10-07 | 奈克斯特安全有限公司 | 经吸入输送药物的方法和系统 |
CN203291353U (zh) * | 2013-06-19 | 2013-11-20 | 林信涌 | 保健气体产生器 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109336816A (zh) * | 2018-09-29 | 2019-02-15 | 中国药科大学 | 一种塞来昔布吲哚美辛的共无定形物 |
Also Published As
Publication number | Publication date |
---|---|
US20150272869A1 (en) | 2015-10-01 |
US9339456B2 (en) | 2016-05-17 |
JP2015205863A (ja) | 2015-11-19 |
TWI586383B (zh) | 2017-06-11 |
DE102015104361B4 (de) | 2019-01-31 |
TW201540328A (zh) | 2015-11-01 |
DE102015104361A1 (de) | 2015-10-22 |
KR20150120851A (ko) | 2015-10-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108295352B (zh) | 保健气体产生系统 | |
CN203291353U (zh) | 保健气体产生器 | |
CN105012341A (zh) | 一种用于治疗肺癌的吸入式药物组合物及其制备方法 | |
CN104940209A (zh) | 一种用于治疗阿兹海默症的吸入式药物组合物及其制备方法 | |
TWM483791U (zh) | 保健氣體產生器 | |
TWI569816B (zh) | 一種用於治療痛風之吸入式醫藥組成物及其備製方法 | |
CN104940223A (zh) | 一种用于治疗心脏病的吸入式药物组合物及其制备方法 | |
CN104940224A (zh) | 一种用于治疗帕金森氏症的吸入式药物组合物及其制备方法 | |
CN105012337A (zh) | 一种用于治疗关节炎的吸入式药物组合物及其制备方法 | |
CN105012300A (zh) | 一种用于治疗高血压的吸入式药物组合物及其制备方法 | |
CN105012277A (zh) | 一种用于治疗肾脏病的吸入式药物组合物及其制备方法 | |
TWI590838B (zh) | 一種用於治療糖尿病之吸入式醫藥組成物及其備製方法 | |
CN111701132A (zh) | 一种具有加热雾化药品的氢氧呼吸机 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20151104 |
|
WD01 | Invention patent application deemed withdrawn after publication |