CN104995300B - Rna活性和血管通透性的调节 - Google Patents

Rna活性和血管通透性的调节 Download PDF

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CN104995300B
CN104995300B CN201380061417.2A CN201380061417A CN104995300B CN 104995300 B CN104995300 B CN 104995300B CN 201380061417 A CN201380061417 A CN 201380061417A CN 104995300 B CN104995300 B CN 104995300B
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oligonucleotides
seq
mir
bases
oligonucleotide
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CN104995300A (zh
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詹尼弗·甘布尔
马修·瓦达斯
索尔莱夫·默勒
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Centenary Institute of Cancer Medicine and Cell Biology
University of Sydney
MIRRX THERAPEUTICS AS
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Centenary Institute of Cancer Medicine and Cell Biology
University of Sydney
MIRRX THERAPEUTICS AS
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CN201380061417.2A 2012-10-02 2013-10-02 Rna活性和血管通透性的调节 Active CN104995300B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2012904297 2012-10-02
AU2012904297A AU2012904297A0 (en) 2012-10-02 Modulation of RNA activity and vascular permeability
AU2012904365 2012-10-05
AU2012904365A AU2012904365A0 (en) 2012-10-05 Modulation of RNA activity and vascular permeability
PCT/AU2013/001129 WO2014053014A1 (en) 2012-10-02 2013-10-02 Modulation of rna activity and vascular permeability

Publications (2)

Publication Number Publication Date
CN104995300A CN104995300A (zh) 2015-10-21
CN104995300B true CN104995300B (zh) 2018-07-17

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US (1) US9879255B2 (OSRAM)
EP (1) EP2904102B1 (OSRAM)
JP (1) JP6430945B2 (OSRAM)
CN (1) CN104995300B (OSRAM)
AU (1) AU2013327393B2 (OSRAM)
CA (1) CA2886745A1 (OSRAM)
WO (1) WO2014053014A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9879255B2 (en) 2012-10-02 2018-01-30 University Of Newcastle Upon Tyne Modulation of RNA activity and vascular permeability
CN108348539A (zh) * 2015-08-05 2018-07-31 癌症医学和细胞生物学百年研究所 用于治疗肿瘤的方法
CN105861728B (zh) * 2016-06-12 2024-11-19 上海市第十人民医院 循环miRNA作为年龄相关黄斑变性诊断标志物中的应用
WO2025102119A1 (en) * 2023-11-16 2025-05-22 Centenary Institute Of Cancer Medicine And Cell Biology Improvement of blood brain barrier integrity

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101641440A (zh) * 2006-11-23 2010-02-03 米尔克斯治疗有限责任公司 用于调节靶rna活性的寡核苷酸
CN101821390A (zh) * 2007-06-14 2010-09-01 米尔克斯治疗有限责任公司 用于调节靶rna活性的寡核苷酸
WO2010139026A1 (en) * 2009-06-05 2010-12-09 Centenary Institute Of Cancer Medicine And Cell Biology Therapeutic and diagnostic molecules
US20110065778A1 (en) * 2002-02-20 2011-03-17 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Muscarinic Colinergic Receptor Gene Expression Using Short Interfering Nucleic Acid (siNA)

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JP2000103736A (ja) * 1998-07-31 2000-04-11 Takeda Chem Ind Ltd 血管透過性亢進抑制剤
JP2000143536A (ja) * 1998-11-13 2000-05-23 Nippon Zoki Pharmaceut Co Ltd 抗浮腫剤
EP1900374B1 (en) * 2005-06-16 2014-03-12 Takayuki Shindo Angiogenetic agent containing adrenomedulin as the active ingredient
US20100021914A1 (en) 2006-11-23 2010-01-28 Querdenker Aps Oligonucleotides for modulating target rna activity
AU2014250708B2 (en) 2006-11-23 2016-11-10 Guangdong Maijinjia Biotechnology Co., Ltd Oligonucleotides for modulating target RNA activity
DK2326332T3 (da) * 2009-06-22 2013-03-04 Dmi Acquistion Corp Fremgangsmåde til behandling af sygdomme
EP2550360B1 (en) 2010-03-24 2017-08-30 Mirrx Therapeutics A/s Bivalent antisense oligonucleotides
EP2643341A4 (en) 2010-11-23 2014-08-27 Mirrx Therapeutics As Oligonucleotides for modulating a TARGET RNA activity
EP2900822B1 (en) 2012-09-26 2021-11-24 Guangdong Maijinjia Biotechnology Co., Ltd Oligomers with improved off-target profile
US9879255B2 (en) 2012-10-02 2018-01-30 University Of Newcastle Upon Tyne Modulation of RNA activity and vascular permeability
JP2015534942A (ja) 2012-10-19 2015-12-07 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ Ｃｂｐ／カテニン阻害剤を用いる過剰増殖性及び前がん性皮膚病の治療

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110065778A1 (en) * 2002-02-20 2011-03-17 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Muscarinic Colinergic Receptor Gene Expression Using Short Interfering Nucleic Acid (siNA)
CN101641440A (zh) * 2006-11-23 2010-02-03 米尔克斯治疗有限责任公司 用于调节靶rna活性的寡核苷酸
CN101821390A (zh) * 2007-06-14 2010-09-01 米尔克斯治疗有限责任公司 用于调节靶rna活性的寡核苷酸
WO2010139026A1 (en) * 2009-06-05 2010-12-09 Centenary Institute Of Cancer Medicine And Cell Biology Therapeutic and diagnostic molecules

Non-Patent Citations (2)

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Title
The Oncogenic microRNA-27a Targets Genes That Regulate Specificity Protein Transcription Factors and the G2-M Checkpoint in MDA-MB-231 Breast Cancer Cells;Susanne U. Mertens-Talcott 等;《Cancer Res》;20071215;第67卷(第2期);第2043-2049页 *
血清microRNAs在胃肠道疾病中的意义;熊青 等;《世界华人消化杂志》;20120808;第20卷(第22期);第11001-11011页 *

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Publication number Publication date
US20160040160A1 (en) 2016-02-11
JP6430945B2 (ja) 2018-11-28
EP2904102A4 (en) 2016-07-06
AU2013327393B2 (en) 2019-07-18
EP2904102A1 (en) 2015-08-12
AU2013327393A1 (en) 2015-05-21
CN104995300A (zh) 2015-10-21
US9879255B2 (en) 2018-01-30
JP2015533085A (ja) 2015-11-19
WO2014053014A1 (en) 2014-04-10
CA2886745A1 (en) 2014-04-10
EP2904102B1 (en) 2018-11-21

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