CN104981250A - 用于治疗贫血的方法 - Google Patents

用于治疗贫血的方法 Download PDF

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Publication number
CN104981250A
CN104981250A CN201380067832.9A CN201380067832A CN104981250A CN 104981250 A CN104981250 A CN 104981250A CN 201380067832 A CN201380067832 A CN 201380067832A CN 104981250 A CN104981250 A CN 104981250A
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CN
China
Prior art keywords
gdf11
actriia
antagonist
seq
actriib
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380067832.9A
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English (en)
Chinese (zh)
Inventor
维多利亚·松
拉杰什·乔普拉
奥利维尔·赫尔米内
伊凡·克鲁兹莫拉
迈克尔·杜赛特
蒂亚戈·特罗瓦蒂马切尔
奥雷利·弗里克
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Celgene Corp
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Celgene Corp
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Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Priority to CN202011541918.9A priority Critical patent/CN112933223A/zh
Priority to CN202011542063.1A priority patent/CN112957462A/zh
Publication of CN104981250A publication Critical patent/CN104981250A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201380067832.9A 2012-10-24 2013-10-23 用于治疗贫血的方法 Pending CN104981250A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202011541918.9A CN112933223A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法
CN202011542063.1A CN112957462A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718128P 2012-10-24 2012-10-24
US61/718,128 2012-10-24
PCT/US2013/066353 WO2014066487A2 (en) 2012-10-24 2013-10-23 Methods for treating anemia

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202011542063.1A Division CN112957462A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法
CN202011541918.9A Division CN112933223A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法

Publications (1)

Publication Number Publication Date
CN104981250A true CN104981250A (zh) 2015-10-14

Family

ID=50545463

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201380067832.9A Pending CN104981250A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法
CN202011541918.9A Pending CN112933223A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法
CN202011542063.1A Pending CN112957462A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法

Family Applications After (2)

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CN202011541918.9A Pending CN112933223A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法
CN202011542063.1A Pending CN112957462A (zh) 2012-10-24 2013-10-23 用于治疗贫血的方法

Country Status (9)

Country Link
US (1) US20150266950A1 (https=)
EP (2) EP3527219A1 (https=)
JP (3) JP6401172B2 (https=)
CN (3) CN104981250A (https=)
AU (4) AU2013334660B2 (https=)
CA (1) CA2889286A1 (https=)
HK (1) HK1214504A1 (https=)
NZ (1) NZ747350A (https=)
WO (1) WO2014066487A2 (https=)

Cited By (2)

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CN107011430A (zh) * 2017-04-07 2017-08-04 哈尔滨医科大学 一种具有生物学活性的截短的生长分化因子11及其制备方法
CN112601538A (zh) * 2018-05-09 2021-04-02 科乐斯疗法公司 激活素受体iia型变体及其使用方法

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US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
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EA018221B1 (ru) 2007-02-09 2013-06-28 Акселерон Фарма Инк. АНТАГОНИСТЫ АКТИВИНА-ActRIIa И ПРИМЕНЕНИЕ ДЛЯ СТИМУЛЯЦИИ РОСТА КОСТИ У БОЛЬНЫХ РАКОМ
CN101861161B (zh) 2007-09-18 2017-04-19 阿塞勒隆制药公司 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
TW201803586A (zh) 2008-08-14 2018-02-01 艾瑟勒朗法瑪公司 使用ｇｄｆ阱以增加紅血球水平
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KR20180026795A (ko) 2009-06-12 2018-03-13 악셀레론 파마 인코포레이티드 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질
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CN114699529A (zh) 2014-06-13 2022-07-05 阿塞勒隆制药公司 用于治疗溃疡的方法和组合物
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US20180125928A1 (en) * 2015-05-13 2018-05-10 Celgene Corporation Treatment of beta-thalassemia using actrii ligand traps
CN108350057A (zh) 2015-05-20 2018-07-31 细胞基因公司 使用II型活化素受体配体阱的用于β-地中海贫血的体外细胞培养方法
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107011430A (zh) * 2017-04-07 2017-08-04 哈尔滨医科大学 一种具有生物学活性的截短的生长分化因子11及其制备方法
CN107011430B (zh) * 2017-04-07 2020-09-01 哈尔滨医科大学 一种具有生物学活性的截短的生长分化因子11及其制备方法
CN112601538A (zh) * 2018-05-09 2021-04-02 科乐斯疗法公司 激活素受体iia型变体及其使用方法
CN112601538B (zh) * 2018-05-09 2025-08-19 科乐斯疗法公司 激活素受体iia型变体及其使用方法

Also Published As

Publication number Publication date
JP6401172B2 (ja) 2018-10-10
WO2014066487A2 (en) 2014-05-01
NZ747350A (en) 2020-07-31
EP3527219A1 (en) 2019-08-21
AU2013334660B2 (en) 2018-08-09
EP2911682A4 (en) 2016-03-23
AU2022201923A1 (en) 2022-04-14
AU2018256635A1 (en) 2018-11-22
AU2020203198A1 (en) 2020-06-11
US20150266950A1 (en) 2015-09-24
CA2889286A1 (en) 2014-05-01
WO2014066487A3 (en) 2014-06-19
CN112957462A (zh) 2021-06-15
JP2016503398A (ja) 2016-02-04
JP2020183390A (ja) 2020-11-12
HK1214504A1 (zh) 2016-07-29
CN112933223A (zh) 2021-06-11
AU2013334660A1 (en) 2015-05-14
AU2020203198B2 (en) 2021-12-23
EP2911682A2 (en) 2015-09-02
JP2018184430A (ja) 2018-11-22

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