CN104971367A - Imaging-assisting traditional Chinese medicine for imaging diagnosis and preparation method thereof - Google Patents

Imaging-assisting traditional Chinese medicine for imaging diagnosis and preparation method thereof Download PDF

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CN104971367A
CN104971367A CN201510354970.6A CN201510354970A CN104971367A CN 104971367 A CN104971367 A CN 104971367A CN 201510354970 A CN201510354970 A CN 201510354970A CN 104971367 A CN104971367 A CN 104971367A
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牛灵芝
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Abstract

The invention provides an imaging-assisting traditional Chinese medicine for imaging diagnosis and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicinal materials: hippopus hippopus, burmannia coelestis, ludwigia hyssopifo-lia, lysimachia congestiflora, clamshell, clematis tangutica, brooklet anemone root, justicia procumbens, pilea notata, artocarpus hypargyraus, gomphocarpus fruticosus, elecampane, caesalpinia millettii, lysimachia congestiflora, eriosema himalaicum, bischofia polycarpa, frangrant ainsliaea herb and asterina pectinifera. The traditional Chinese medicine has the benefits as follows: the imaging-assisting traditional Chinese medicine is safe and convenient to use and has no side effects; and during a B ultrasonic image examination and diagnosis process, the traditional Chinese medicine can well relieve hyperacidity to alleviate stomachache, strengthen the spleen and stomach, and disperse accumulations to remove flatulence; inspection time is shortened; the imaging rate is increased; a strong basis is provided for clinical diagnosis; and the traditional Chinese medicine is a relatively ideal development assisting preparation, is simple in preparation process, and is practical.

Description

A kind of image diagnosis Chinese medicine of assisting video picture and preparation method thereof
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to image diagnosis Chinese medicine of assisting video picture used in a kind of ultrasound diagnosis and preparation method thereof.
Background technology
Ultrasonic image diagnosis is one of important diagnostic method in medical science.Ultrasound wave has three to act on greatly to material: one is mechanism, because ultrasonic energy is huge, often makes material particle do altofrequency mechanical vibration, thus produce smash, condense, agitation effects.Two is warm-heat effect, and ul-trasonic irradiation is when material, and its energy is absorbed by material, thus makes mass temperature raise phenomenon.Three is cavitations, when ul-trasonic irradiation is on liquid, become sparse in the region (if any microscopic bubble etc.) of liquid internal stress weakness due to acoustic pressure great variety, at this moment around under the effect of fluid molecule pulling force, form a little cavity, be cavitation.This cavity time of staying is not long, collapses again under huge acoustic pressure effect, and formed due to cavity and disappear, producing a large amount of bubble will affect ultrasonic diagnosis effect, so, eliminate the Main Function that bubble is ultrasonic contrast agent.
At present, for B ultrasonic gastrointestinal contrast agent, prior art describes the contrast agent be mixed with by the 100 order fine powders of Endoconcha Sepiae fine powder 80% and the Pseudobulbus Bletillae (Rhizoma Bletillae) 20%, to gastrointestinal disease, there is convergence, antacid effect, but weak point is patient take contrast agent after to produce strong echo luminous point not enough, reflecting effect is not good, and the display of coat of the stomach level is unintelligible; After patient takes this contrast agent, gastric acid strong reaction, has pain and sense of discomfort, is unfavorable for the ultrasonic contrast of gastrointestinal, can not applies this contrast agent to gastrorrhagia patient.
Another kind of fast ultrasonic image-developing liquor preparation method is that make imaging liquid, excellent video picture rate reaches 87% through decocting, distilling, concentrate after bitter bucket, MIXIANG, abdomen floss, Pericarpium Citri Reticulatae Viride, Radix Glycyrrhizae, sucrose being mixed in proportion.Used bitter bucket in this prescription, taste is extremely bitter, thus improves mouthfeel with sucrose, and sucrose enters in gastric juice and easily produces bubble, thus has impact to imaging results, and in addition, this invention product is without therapeutical effect.
Summary of the invention
Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, in ultrasound diagnosis process, provide a kind of use safety, have no side effect, review time is short, and video picture rate is high, image diagnosis Chinese medicine of assisting video picture easy to use and preparation method thereof.
In order to solve the problems of the technologies described above, the invention provides the Chinese medicine that a kind of image diagnosis assists video picture, wherein, described Chinese medicine comprises following raw medicinal material: Hippopus hippopus (Linnaeus), Burmannia coelestis D. Don., careless imperial root, wind and cold grass, Placuna placenta (L.), Herba Clematidis tanguticae, Radix Anemones Rivularis, Justicia procumbens linn., Rhizoma Belamcandae, Gui Mugen, Fructus Gomphocarpi futicosi, Radix Inulae, Caesalpinia milettii Hook (et Arx), rescues temporarily, Eriosema himalaicum Ohashi, Ramulus et Folium Bischofiae Javanicae, Ainsliasa fragrans Champ and Potiria pectinifera (Mukller et Tro Sehel).
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Hippopus hippopus (Linnaeus) 30 ~ 40 parts, Burmannia coelestis D. Don. 5 ~ 15 parts, grass imperial root 5 ~ 15 parts, wind and cold grass 10 ~ 20 parts, Placuna placenta (L.) 15 ~ 25 parts, Herba Clematidis tanguticae 5 ~ 15 parts, Radix Anemones Rivularis 10 ~ 20 parts, Justicia procumbens linn. 10 ~ 20 parts, Rhizoma Belamcandae 30 ~ 40 parts, osmanthus wood root 15 ~ 25 parts, Fructus Gomphocarpi futicosi 15 ~ 25 parts, Radix Inulae 5 ~ 15 parts, Caesalpinia milettii Hook (et Arx) 10 ~ 20 parts, rescues 15 ~ 25 parts temporarily, Eriosema himalaicum Ohashi 30 ~ 40 parts, Ramulus et Folium Bischofiae Javanicae 5 ~ 15 parts, Ainsliasa fragrans Champ 15 ~ 25 parts and Potiria pectinifera (Mukller et Tro Sehel) 20 ~ 30 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Hippopus hippopus (Linnaeus) 30 ~ 35 parts, Burmannia coelestis D. Don. 5 ~ 10 parts, grass imperial root 5 ~ 10 parts, wind and cold grass 10 ~ 15 parts, Placuna placenta (L.) 15 ~ 20 parts, Herba Clematidis tanguticae 5 ~ 10 parts, Radix Anemones Rivularis 10 ~ 15 parts, Justicia procumbens linn. 10 ~ 15 parts, Rhizoma Belamcandae 30 ~ 35 parts, osmanthus wood root 15 ~ 20 parts, Fructus Gomphocarpi futicosi 15 ~ 20 parts, Radix Inulae 5 ~ 10 parts, Caesalpinia milettii Hook (et Arx) 10 ~ 15 parts, rescues 15 ~ 20 parts temporarily, Eriosema himalaicum Ohashi 30 ~ 35 parts, Ramulus et Folium Bischofiae Javanicae 5 ~ 10 parts, Ainsliasa fragrans Champ 15 ~ 20 parts and Potiria pectinifera (Mukller et Tro Sehel) 25 ~ 30 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Hippopus hippopus (Linnaeus) 32 parts, Burmannia coelestis D. Don. 7 parts, careless imperial root 8 parts, wind and cold grass 13 parts, Placuna placenta (L.) 18 parts, Herba Clematidis tanguticae 7 parts, Radix Anemones Rivularis 11 parts, Justicia procumbens linn. 14 parts, Rhizoma Belamcandae 34 parts, osmanthus wood root 16 parts, Fructus Gomphocarpi futicosi 18 parts, Radix Inulae 6 parts, Caesalpinia milettii Hook (et Arx) 11 parts, rescues 20 parts temporarily, Eriosema himalaicum Ohashi 32 parts, Ramulus et Folium Bischofiae Javanicae 5 parts, Ainsliasa fragrans Champ 16 parts and Potiria pectinifera (Mukller et Tro Sehel) 26 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Hippopus hippopus (Linnaeus) 35 parts, Burmannia coelestis D. Don. 5 parts, careless imperial root 5 parts, wind and cold grass 10 parts, Placuna placenta (L.) 16 parts, Herba Clematidis tanguticae 10 parts, Radix Anemones Rivularis 15 parts, Justicia procumbens linn. 10 parts, Rhizoma Belamcandae 30 parts, osmanthus wood root 20 parts, Fructus Gomphocarpi futicosi 15 parts, Radix Inulae 10 parts, Caesalpinia milettii Hook (et Arx) 15 parts, rescues 15 parts temporarily, Eriosema himalaicum Ohashi 35 parts, Ramulus et Folium Bischofiae Javanicae 10 parts, Ainsliasa fragrans Champ 20 parts and Potiria pectinifera (Mukller et Tro Sehel) 29 parts.
In order to solve the problems of the technologies described above, the invention provides the preparation method that a kind of above-mentioned image diagnosis assists the Chinese medicine of video picture, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
In order to solve the problems of the technologies described above, invention further provides the preparation method that a kind of above-mentioned image diagnosis assists the Chinese medicine of video picture, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 DEG C ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 DEG C ~ 175 DEG C, leaving air temp 80 DEG C ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 DEG C ~ 50 DEG C dryings, obtains granule.
Beneficial effect of the present invention: the Chinese medicine of auxiliary video picture of the present invention, use safety, convenience, have no side effect; And in the image check carrying out B ultrasonic and diagnostic procedure, can be good at relieving gastric hyperacidity to alleviate stomachache, invigorating the spleen and regulating the stomach and removing stagnancy of indigested food and relieving flatulence, shorten the review time, improve video picture rate, for clinical diagnosis provides strong foundation, be ideal auxiliary development preparation, and preparation technology is simple, practical.
Detailed description of the invention
The invention provides the Chinese medicine that a kind of image diagnosis assists video picture, described Chinese medicine comprises following raw medicinal material: Hippopus hippopus (Linnaeus), Burmannia coelestis D. Don., the imperial root of grass, wind and cold grass, Placuna placenta (L.), Herba Clematidis tanguticae, Radix Anemones Rivularis, Justicia procumbens linn., Rhizoma Belamcandae, Gui Mugen, Fructus Gomphocarpi futicosi, Radix Inulae, Caesalpinia milettii Hook (et Arx), rescues temporarily, Eriosema himalaicum Ohashi, Ramulus et Folium Bischofiae Javanicae, Ainsliasa fragrans Champ and Potiria pectinifera (Mukller et Tro Sehel).
The pharmacology of various raw medicinal material is as follows:
Hippopus hippopus (Linnaeus): [another name] clam, prosperous pretty young woman.[source] medical material Ji Yuan: be shell or the entirety of Tridacnidae animal Che oyster.[nature and flavor] sweet in the mouth; Salty; Cold in nature.[return through] spleen; Lung meridian.[function cures mainly] heat-clearing and toxic substances removing; Removing food stagnancy relieves the effect of alcohol.Main carbuncle on the back carbuncle; Furuncle toxic swelling, wine amasss addiction block.[extracts] " China's book on Chinese herbal medicine "
Burmannia coelestis D. Don.: [another name] meter Yang Can.The rhizome that [source] is Burmanniaceae plant three products YIZHIHUA and root.Autumn gathers.[nature and flavor] property is put down, sweet in the mouth.[function cures mainly] spleen invigorating, lung moistening.[extracts] " Chinese medicine voluminous dictionary "
Grass imperial root: [source] medical material Ji Yuan: be the root of onagraceae plant line leaf Herba Ludwigiae Prostratae.[nature and flavor] bitter in the mouth; Property is put down.[function cures mainly] antiasthmatic-antitussive; Removing food stagnancy; Eliminating stagnation.Main asthma; Cough; Infantile malnutrition; Scrofula.[extracts] " China's book on Chinese herbal medicine "
Wind and cold grass: [another name] Lysimachia christinae Hance, Herba Lysimachiae Congestiflorae, Hu Shi Herba lysimachiae capillipedis, to SHENGHUANG floral leaf, little wind and cold, Herba Lysimachiae Congestiflorae, Hemerocallis citrina Baroni pearl, Liparis plicata Franch .et. Sav, large carbuncle(disease) medicine, climb Radix Rehmanniae Huang.[source] medical material Ji Yuan: be the herb of Ofthe Primulaceae L. congestiflora Hesms.[nature and flavor] are pungent; Micro-hardship; Slightly warm in nature.[function cures mainly] expelling wind and cold; Preventing phlegm from forming and stopping coughing; Detoxification and promoting urination; Removing food stagnancy calculus.Main headche due to wind-cold; Cough with copious phlegm; Laryngopharynx swelling and pain; Jaundice; Biliary Calculi; Lithangiuria; Children's mansion is amassed; Carbuncle furuncle; Venom.[extracts] " China's book on Chinese herbal medicine "
Placuna placenta (L.): [another name] transparent tile (" the middle part of Fujian Province seafood is dredged "), clam shell Zhuang (" Bencao Congxin ").[source] is the shell of Anomiidae animal Placuna placenta (L.).[nature and flavor] " Bencao Congxin ": " salty, Great Cold." [function cures mainly] " Bencao Congxin ": " rushes down damp and hot.Decoct soup and wash the arthroncus of knee; Forge and grind as powder, be coated with wet rotten skin ulcer." [extracts] " Chinese medicine voluminous dictionary "
Herba Clematidis tanguticae: [another name] Caulis Akebiae, also to cover.[source] medical material Ji Yuan: be Herb or the stem and leaf of ranunculaceae plant Herba Clematidis tanguticae.[nature and flavor] are sweet; Bitter; Flat.[return through] spleen; Stomach warp.[function cures mainly] stomach invigorating removing food stagnancy; Removing toxic substances removing dampness.Main accumulation of food in the stomach and intes tine due to indigestion; Abdominal distention painful abdominal mass plug; Abdomen gushes diarrhoea; Carbuncle skin ulcer; Eczema.[extracts] " China's book on Chinese herbal medicine "
Radix Anemones Rivularis: [another name] is shown in that wind is blue or green, sees that wind is blue, Gallus Domesticus (" Guizhou side's medicine among the people collection "), sheep nine, Radix Phyllanthi cochinchinensis (" Kweiyang medicinal herbs among the people "), colour of loess a kind of reed mentioned in ancient books (" illustrated handbook planted by middle traditional Chinese medicines "), WUDUOYUN (" Chinese Higher plant illustrated handbook ").The root that [source] is ranunculaceae plant Herba Veronicastri Sibirici or herb.Summer adopts herb, and autumn uproots.[nature and flavor] toil, flat, poisonous.[function cures mainly] heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation.Control throat moth, mumps, scrofula tuberculosis, swollen ulcer drug, malaria, rheumatalgia, stomachache, traumatic injury." Qinghai-Tibet medicine illustrated handbook ": " enrich blood, warm body, removing food stagnancy, dries, more wound, evacuation of pus.After curing the disease, body temperature is not enough, gonorrhea, and yellow fluid is amassed in joint, impetigo (external application can harness the Yellow River chickenpox or propose yellow fluid in joint), chronic tracheitis, peripheral nerve paralysis, emetic gastric acid." [extracts] " Chinese medicine voluminous dictionary "
Justicia procumbens linn.: [source] Acanthaceae Justicia procumbens linn. Rungia cantonensis How.[nature and flavor] micro-hardship, light, cool.[function cures mainly] calming liver and clearing heat, consumer product dredge stasis.Cure mainly infantile malnutrition, acute conjunctivitis, hepatitis, flu, laryngalgia, lymphoid tuberculosis, breast ulcer, furuncle and phyma.[extracts] " national Chinese herbal medicine compilation "
Rhizoma Belamcandae: [another name] Herba Pileae Notatae (Herba Oreocnides frutescentis), native Radix Glycyrrhizae, Sanguis Naemorhedi, white goat, Herba Hedyotis cantonensis.[source] medical material Ji Yuan: be the herb of contrayerva Rhizoma Belamcandae.[nature and flavor] are light; Micro-hardship; Cool in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Jaundice eliminating; Dispersing swelling and dissipating binds; Invigorating the spleen and regulating the stomach.Main jaundice due to damp-heat; Leucorrhea with red and white discharge; Stranguria with turbid discharge; Hematuria; Infantile Summer Fever; Malaria with splenomegaly; Dyspepsia; Traumatic injury; Trauma infection contamination.[extracts] " China's book on Chinese herbal medicine "
Gui Mugen: [source] medical material Ji Yuan: be the root of moraceae plants osmanthus wood.[nature and flavor] are pungent; Slightly warm in nature.[return through] stomach warp.[function cures mainly] invigorating the spleen and regulating the stomach; Expelling wind and activating blood circulation.Main gastral cavilty does not relax; Inappetence; Rheumatic arthralgia; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Fructus Gomphocarpi futicosi: [source] medical material Ji Yuan: be the aerial parts of trailing plants section plant Fructus Gomphocarpi futicosi.[nature and flavor] are sweet; Flat.[return through] spleen; Stomach warp.[function cures mainly] invigorating the spleen and regulating the stomach; Lung benefiting.Main vomiting in children; Have loose bowels; Do not think to receive food; Pulmonary tuberculosis cough.[extracts] " China's book on Chinese herbal medicine "
Radix Inulae: [another name] Radix Aristolochiae, Qi Muxiang, Radix Inulae.[source] medical material Ji Yuan: be the root of feverfew Radix Inulae.Latin plant animal mineral name: Inula helenium L. gathers and stores: excavate when the Frost's Descent, posterior lobe was withered, removing stem and leaf, fibrous root and earth, intercept, thicker rip cutting becomes lobe, dries.[nature and flavor] acrid in the mouth; Bitter; Warm in nature.[return through] returns spleen; Stomach; Liver Channel.[function cures mainly] invigorating the spleen and regulating the stomach; Promoting the circulation of QI to relieve pain; Drive early.Main gastral cavilty; Born of the same parents' abdominal distention and pain; Tell diarrhoea; Dysentery; Food stagnation; Early long-pending.[extracts] " China's book on Chinese herbal medicine "
Caesalpinia milettii Hook (et Arx): [source] medical material Ji Yuan: be the root of leguminous plant Caesalpinia milettii Hook (et Arx).[nature and flavor] are sweet; Temperature.[return through] stomach; Spleen channel.[function cures mainly] expelling wind and removing dampness, invigorating the spleen and regulating the stomach.Main air pain of dampness syndrome, gastropathy, dyspepsia.[extracts] " China's book on Chinese herbal medicine "
Rescue: [another name] Herba Malvastri Coromandeliani, Liparis plicata Franch .et. Sav, Pheretima of crawling (" Hunan medicine will ") temporarily.[source] is the herb of Ofthe Primulaceae Hu Shi Herba lysimachiae capillipedis.[nature and flavor] " Hunan medicine will ": " bitter, cool, nontoxic." [function cures mainly] removing food stagnancy, dissipating blood stasis, controls infantile malnutrition, amenorrhea, traumatic injury, carbuncle, furuncle." Hunan medicine will ": " reason diabetes involving middle-JIAO amasss, heat-clearing and toxic substances removing.Control infantile malnutrition, married woman's amenorrhea, scabies." [extracts] " Chinese medicine voluminous dictionary "
Eriosema himalaicum Ohashi: the short top top of [another name] Cor Gigeriae Galli, napiform root hair hemp nettle.[source] pulse family hair hemp nettle platymiscium Eriosema himalaicum Ohashi, is used as medicine with tuber.Autumn adopts, and cleans section, dries.[nature and flavor] are sweet, bitter, puckery, flat.[function cures mainly] stomach invigorating removing food stagnancy, regulating QI to relieve pain.For infantile malnutrition, dyspepsia, stomach abdomen pain, diarrhoea, traumatic injury.[extracts] " national Chinese herbal medicine compilation "
Ramulus et Folium Bischofiae Javanicae: [another name] autumn wind (" Gui Haiyu weigh will "), Populus euphratica, red paulownia, Qie Cutters set, Ramulus et Folium Bischofiae Javanicae (" Chinese tree taxonomy "), and water balk, SANYE are red, duck foot maple, a thousand pieces of gold do not fall, Ramulus et Folium Claoxyli (" register planted by Guangxi medicine ").Root, bark, branch and leaf that [source] is euphorbia plant Bischofia polycarpa.Summer, autumn gather.[nature and flavor] are " Luchuan book on Chinese herbal medicine " 1.: " arduous, tepor." [function cures mainly] be " Luchuan book on Chinese herbal medicine " 1.: " branch and leaf and skin: wind dispelling, invigorate blood circulation, detumescence.Dispelling the wind and dampness pathogens osteodynia." " Quanzhou book on Chinese herbal medicine ": " leaf: promoting flow of QI and blood, detumescence relieves internal heat.Control QI and blood pent-up, ulcer sores." " register planted by Guangxi medicine ": " root: control red-white dysentery." [extracts] " Chinese medicine voluminous dictionary "
Ainsliasa fragrans Champ: [another name] Linear Leaf Speedwell.[Zhejiang, Fujian], Ainsliaea fragrans Champ. [Guangdong], rabbit ear Linear Leaf Speedwell, towards sky Linear Leaf Speedwell, four leaf Linear Leaf Speedwells, fall to the ground Jin Zhong.[source] is Compositae Ainsliaea fragrans Champ. platymiscium Ainsliasa fragrans Champ, with all herbal medicine.Xia Qiu gathers, and cleans, using fresh herb or dry for subsequent use.[nature and flavor] are bitter, pungent, flat.[function cures mainly] heat-clearing and toxic substances removing, removing food stagnancy eliminating stagnation, cough-relieving, hemostasis.For upper respiratory tract infection, lung abscess, hemoptysis of pulmonary tuberculosis, jaundice, infantile malnutrition, dyspepsia, mastitis; Otitis media is controlled in external, venom.[extracts] " national Chinese herbal medicine compilation "
Potiria pectinifera (Mukller et Tro Sehel): [another name] five-pointed star, extra large five-pointed star.[source] medical material Ji Yuan: be the entirety of Asterinidae animal Potiria pectinifera (Mukller et Tro Sehel).Gather and store: after seizure, removing internal organs, cleaning, dry.[nature and flavor] salty in the mouth; Warm in nature.[return through] kidney; Stomach warp.[function cures mainly] mends hard; Wind-damp dispelling; Antacid; Pain relieving.Main sexual impotence; Lumbago, skelalgia of rheumatism; Impairment caused by overstrain pain; Stomachache pantothenic acid.[extracts] " China's book on Chinese herbal medicine "
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Hippopus hippopus (Linnaeus) 30 ~ 40 parts, Burmannia coelestis D. Don. 5 ~ 15 parts, grass imperial root 5 ~ 15 parts, wind and cold grass 10 ~ 20 parts, Placuna placenta (L.) 15 ~ 25 parts, Herba Clematidis tanguticae 5 ~ 15 parts, Radix Anemones Rivularis 10 ~ 20 parts, Justicia procumbens linn. 10 ~ 20 parts, Rhizoma Belamcandae 30 ~ 40 parts, osmanthus wood root 15 ~ 25 parts, Fructus Gomphocarpi futicosi 15 ~ 25 parts, Radix Inulae 5 ~ 15 parts, Caesalpinia milettii Hook (et Arx) 10 ~ 20 parts, rescue 15 ~ 25 parts temporarily, Eriosema himalaicum Ohashi 30 ~ 40 parts, Ramulus et Folium Bischofiae Javanicae 5 ~ 15 parts, Ainsliasa fragrans Champ 15 ~ 25 parts and Potiria pectinifera (Mukller et Tro Sehel) 20 ~ 30 parts.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be preferably: Hippopus hippopus (Linnaeus) 30 ~ 35 parts, Burmannia coelestis D. Don. 5 ~ 10 parts, grass imperial root 5 ~ 10 parts, wind and cold grass 10 ~ 15 parts, Placuna placenta (L.) 15 ~ 20 parts, Herba Clematidis tanguticae 5 ~ 10 parts, Radix Anemones Rivularis 10 ~ 15 parts, Justicia procumbens linn. 10 ~ 15 parts, Rhizoma Belamcandae 30 ~ 35 parts, osmanthus wood root 15 ~ 20 parts, Fructus Gomphocarpi futicosi 15 ~ 20 parts, Radix Inulae 5 ~ 10 parts, Caesalpinia milettii Hook (et Arx) 10 ~ 15 parts, rescue 15 ~ 20 parts temporarily, Eriosema himalaicum Ohashi 30 ~ 35 parts, Ramulus et Folium Bischofiae Javanicae 5 ~ 10 parts, Ainsliasa fragrans Champ 15 ~ 20 parts and Potiria pectinifera (Mukller et Tro Sehel) 25 ~ 30 parts.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably again: Hippopus hippopus (Linnaeus) 32 parts, Burmannia coelestis D. Don. 7 parts, grass imperial root 8 parts, wind and cold grass 13 parts, Placuna placenta (L.) 18 parts, Herba Clematidis tanguticae 7 parts, Radix Anemones Rivularis 11 parts, Justicia procumbens linn. 14 parts, Rhizoma Belamcandae 34 parts, osmanthus wood root 16 parts, Fructus Gomphocarpi futicosi 18 parts, Radix Inulae 6 parts, Caesalpinia milettii Hook (et Arx) 11 parts, rescues 20 parts temporarily, Eriosema himalaicum Ohashi 32 parts, Ramulus et Folium Bischofiae Javanicae 5 parts, Ainsliasa fragrans Champ 16 parts and Potiria pectinifera (Mukller et Tro Sehel) 26 parts.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably again: Hippopus hippopus (Linnaeus) 35 parts, Burmannia coelestis D. Don. 5 parts, grass imperial root 5 parts, wind and cold grass 10 parts, Placuna placenta (L.) 16 parts, Herba Clematidis tanguticae 10 parts, Radix Anemones Rivularis 15 parts, Justicia procumbens linn. 10 parts, Rhizoma Belamcandae 30 parts, osmanthus wood root 20 parts, Fructus Gomphocarpi futicosi 15 parts, Radix Inulae 10 parts, Caesalpinia milettii Hook (et Arx) 15 parts, rescues 15 parts temporarily, Eriosema himalaicum Ohashi 35 parts, Ramulus et Folium Bischofiae Javanicae 10 parts, Ainsliasa fragrans Champ 20 parts and Potiria pectinifera (Mukller et Tro Sehel) 29 parts.
When the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 DEG C ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 DEG C ~ 175 DEG C, leaving air temp 80 DEG C ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 DEG C ~ 50 DEG C dryings, obtains granule.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: capsule
Pick up the car chela 320g, Burmannia coelestis D. Don. 70g, careless imperial root 80g, wind and cold grass 130g, Placuna placenta (L.) 180g, Herba Clematidis tanguticae 70g, Radix Anemones Rivularis 110g, Justicia procumbens linn. 140g, Rhizoma Belamcandae 340g, osmanthus wood root 160g, Fructus Gomphocarpi futicosi 180g, Radix Inulae 60g, Caesalpinia milettii Hook (et Arx) 110g, rescues 200g temporarily, Eriosema himalaicum Ohashi 320g, Ramulus et Folium Bischofiae Javanicae 50g, Ainsliasa fragrans Champ 160g and Potiria pectinifera (Mukller et Tro Sehel) 260g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.18:0.26, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Embodiment 2: granule
Pick up the car chela 350g, Burmannia coelestis D. Don. 50g, careless imperial root 50g, wind and cold grass 100g, Placuna placenta (L.) 160g, Herba Clematidis tanguticae 100g, Radix Anemones Rivularis 150g, Justicia procumbens linn. 100g, Rhizoma Belamcandae 300g, osmanthus wood root 200g, Fructus Gomphocarpi futicosi 150g, Radix Inulae 100g, Caesalpinia milettii Hook (et Arx) 150g, rescues 150g temporarily, Eriosema himalaicum Ohashi 350g, Ramulus et Folium Bischofiae Javanicae 100g, Ainsliasa fragrans Champ 200g and Potiria pectinifera (Mukller et Tro Sehel) 290g.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.07, spraying dry, the inlet temperature 168 DEG C of spray dryer, leaving air temp 82 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.28 times and 0.16 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.
Acute toxicity test: be dissolved in distilled water with capsule prepared by the embodiment of the present invention 1, gives 4 groups of white mice feeding dispensings or wiping respectively with 80 of clinical consumption per day times, 120 times, 150 times and 230 times, observes 7; The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.
Long term toxicity test: the capsule embodiment of the present invention 1 prepared is dissolved in water by 16.25g crude drug/kg, to mice continuous use 16 weeks, every day 2 times, and drug withdrawal is after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to test mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Pharmacodynamic experiment:
One, the impact that the tablet of video picture preparation moves on small intestine movement of mice assisted by Chinese medicine of the present invention.
1, test material:
1.1, experimental animal: the ICR mice 150 that Jun Ke bio tech ltd, Nanjing cultivates, male and female half and half, body weight 15 ~ 25g.
1.2, trial drug:
1.2.1 the capsule of video picture preparation assisted by Chinese medicine of the present invention.Capsule distilled water of the present invention is dissolved into 0.533,0.267, the medicinal liquid of 0.133g crude drug/ml is stand-by.
1.2.2 atropine sulfate injection (Tianjin KingYork Amino Acid Co., Ltd., the accurate word H12020383 of traditional Chinese medicines), uses front normal saline dilution to become 0.01mg/ml solution.
1.2.3 active carbon; Arabic gum (making containing 10% Radix Acaciae senegalis, the charcoal end distilled water suspension of 5% active carbon).
1.3 testing equipments: SE602FZH and SE202FZH electronic balance (Ohaus Instrument (Changzhou) Co., Ltd.).
2, test method:
Select 15 ~ 25g body weight mice, be divided into 5 groups by the method for body weight random stratified, be i.e. blank group, positive drug (atropine) group, the high, medium and low dosage group of Chinese medicinal tablet of the present invention.Often organize 30, male and female half and half.Blank group and atropine group gavage distilled water 30ml/kg, the other gavage of high, medium and low dosage component Chinese medicine capsules medicinal liquid of the present invention 16,8,4g crude drug/kg, 1 time/d.Gavage is after 7 days, can't help water 18h in the experiment the previous day of fasting at dusk, and after the 8th day last administration 1h (atropine diluent 0.1mg/kg 5min), each group gavage charcoal end suspension 0.2ml/ only.Animal is put to death after 20min; open abdominal cavity and be separated mesentery; see that coat of the stomach clear layer is visible, and this auxiliary video picture preparation takes down, stomach week mucosa is played a protective role; ultrasound display screen can be seen place's video pictures such as gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, greater gastric curvature obvious; each position focus is high-visible, and to perigastric organs as liver, gallbladder, pancreas display clear, clip front end is to pylorus; rear end, to the intestinal tube of ileocecus, is placed on pallet.Gently small intestinal is put into straight line, measures Length of intestine as " total small intestinal length ".From pylorus to the distance in prepared Chinese ink forward position as " distance that prepared Chinese ink advances at enteral ".Formulae discovery ink progradation: ink progradation=(prepared Chinese ink is in enteral advance distance/small intestinal total length) × 100%.
3, result of the test:
Compare with matched group, positive drug atropine group charcoal end delaunay triangle rate obviously reduces (P<0.05), and the gastric peristalsis of Chinese medicine capsules of the present invention is obviously hyperfunction, compares with model control group, can obviously promote gastrointestinal motility function.In table 1.
Table 1 Chinese medicine of the present invention assists the tablet of video picture preparation on the impact of the hyperfunction mouse small intestine motion of intestinal propulsion
Group Number of cases Delaunay triangle rate %
Normal group 30 43.26±5.13
Positive drug atropine group 30 57.41±8.52***
Tablets 4g crude drug/kg 30 68.24±12.51**
Tablets 8g crude drug/kg 30 79.48±11.28
Tablets 16g crude drug/kg 30 92.36±9.47
Note: compare with Normal group: P<0.05, compares with model control group: * * P<0.01, * * * P<0.001.
Conclusion (of pressure testing): Chinese medicine of the present invention assists the capsule 4g/kg of video picture preparation to have obvious inhibitory action to the motion of gastrointestinal motility hyperfunctioning mouse small intestine, increases, show the trend promoting bowel movement effect with dosage.This test have studied from body and the impact of in vitro function of intestinal canal, stopping leak, antibacterial, the anti-immunity of antiinflammatory etc. the tablet in treatment gastropathy that video picture preparation assisted by Chinese medicine of the present invention, the Pharmacological Mechanism of enteritis, dysentery, gastrointestinal motility can be promoted, digestion, absorption, and have certain bacteriostasis, and show the anti-immunization of stronger antiinflammatory.
Two, In vitro Bactericidal Experiments:
Double broth dilution method is adopted to measure the minimum inhibitory concentration (MIC) of the present invention to common pathogen.Be inoculated in by tested bacterium in MH broth bouillon, cultivate after 18 hours for 35 DEG C, adjust the turbidity that its turbidity reaches 0.5 Maxwell opacity tube standard, bacterial content is about 10 8cFU/ml.1:10 (bacteria containing amount about 10 is diluted with physiological saline solution 7cFU/ml).Get the medicinal liquid 2ml diluted for series concentration respectively to add and perform in the flat board of labelling, then the MH agar culture medium 18ml being chilled to about 50 DEG C after getting thawing be added to dull and stereotyped in (medicine: agar=1: 9) makes medicine and culture medium fully mix.Medicine ultimate density is respectively 200mg/ml, 100mg/ml, 50mg/ml, 25mg/ml, 12.5mg/ml, 6.25mg/ml, 3.13mg/ml, 1.56mg/ml, 0.78mg/ml and 0.39mg/ml.Be inoculated on pastille flat board by the bacteria suspension inoculating loop prepared, cultivate 18 hours observed results in 35 DEG C, the lowest concentration of drug that colony growth is totally constrained is that this medicine is to the MIC detecting bacterium.Single bacteria growing can be ignored.Drug control and strain growth contrast are established in test simultaneously.The results are shown in Table 2.
Table 2 extracorporeal bacteria inhibitor test result is as follows:
Bacterial strain Minimum inhibitory concentration (MIC) (mg/ml)
Shigella flexneri 3.925
Paratyphoid bacillus A 10.58
Bacillus paratyphosus B 23.84
Bacillus pyocyaneus 5.36
Escherichia coli 46.82
Bacillus enteritidis 21.37
Staphylococcus aureus 6.81
As seen from Table 2, medicine of the present invention all has certain antibacterial action to shigella flexneri, paratyphoid bacillus A, Bacillus paratyphosus B, escherichia coli, bacillus pyocyaneus, staphylococcus aureus, bacillus enteritidis.
Illustrate: human intestines and stomach belongs to hollow organ, in the ordinary course of things, B ultrasonic is utilized can not well to show coat of the stomach level, the present invention assists Placuna placenta (L.) in the Chinese medicine of video picture and the calcium carbonate of Hippopus hippopus (Linnaeus) all containing certain ingredients, with in gastric acid and after can produce carbon dioxide bubble, and the present invention is when assisting the Chinese medicine of video picture to take or need the 200-500ml that drinks water after taking, obvious relieving gastric hyperacidity to alleviate stomachache effect is played after making various Chinese Medicine and Clavicular, more clear on image, the strong reecho of point-like, see that coat of the stomach clear layer is visible, and this auxiliary video picture preparation takes down, stomach week mucosa is played a protective role, ultrasound display screen can see gastral cavity size, form, cardia, pylorus, gastric antrum, duodenum, lesser gastric curvature, place's video pictures such as greater gastric curvature are obvious, each position focus is high-visible, and to perigastric organs as liver, gallbladder, pancreas display is clear, also can clarify a diagnosis to stomach week status of lymph node metastasis.What the present invention assisted the Chinese medicine of video picture helps shadow principle as follows: with rear generation carbon dioxide bubble in the calcium carbonate in auxiliary video picture Chinese medicine and gastric acid, drink water 200 ~ 500 milliliters and to swim phenomenon in " flakes " afterwards, because the stickum in auxiliary video picture Chinese medicine is to ulcer, cancerous protuberance mucomembranous surface can build up, be fused into rope block or light to clique graph and resemble, form obvious interface, because auxiliary video picture Chinese medicine can make gastral cavity fill the difference causing gastric wall mucus in acoustic impedance, thus display stomach form, position, gastral cavity size, wall of stomach thickness, emptying time and gastropathy place situation, gastrointestinal dysfunction can be shown, the pathological changes at display small intestinal, caecum, each position of colon.
The Chinese medicine of the auxiliary video picture that B ultrasonic of the present invention uses is that pure Chinese medicine assists video picture preparation, no side effects, taking convenience; video picture is clear, strengthens the effect of gastric protective barrier, hemostasis and pain-relieving antacid; diagnosis accurately, is taken through 158 examples are clinical, various gastrointestinal disease of clarifying a diagnosis.Within oral this product 5-15 minute, stomach bubble can be got rid of, eliminate mucus and make the display of coat of the stomach structure clear, clear display stomach different lesions, imaging results is good, and resolving power is high, image stabilization, can gastric B ultrasonic examination inspection be carried out with various ordinary ultrasonography b instrument, and there is invigorating the spleen and regulating the stomach and removing stagnancy of indigested food and relieving flatulence effect.According to clinical diagnostic tests, excellent visualization ratio 96.2% (152 example), general visualization ratio 3.8% (6 example), can go out gastric ulcer 28 example, acute gastritis 26 example, chronic gastritis 37 example, gastric cancer 12 example, polyp of stomach 9 example, gastrointestinal malignant lymphoma 6 example, gastric-intestinal perforation 14 example, duodenitis 16 example, intussusception 6 example and colon cancer 4 example etc. by auxiliary diagnosis.
Concrete case: clock, male, 44 years old, because of right abdominal discomfort, continuous several days distending pains, pain be not very serious, but very uncomfortable and go to see a doctor, through the Chinese medicine capsules 6 of the auxiliary video picture of the oral embodiment of the present invention 1, and drunk 400ml water, after 7 minutes, according to B ultrasonic diagnostic screen displaying contents, be diagnosed as: slight chronic non-atrophy gastritis and duodenitis.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. image diagnosis assists a Chinese medicine for video picture, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Hippopus hippopus (Linnaeus), Burmannia coelestis D. Don., the imperial root of grass, wind and cold grass, Placuna placenta (L.), Herba Clematidis tanguticae, Radix Anemones Rivularis, Justicia procumbens linn., Rhizoma Belamcandae, Gui Mugen, Fructus Gomphocarpi futicosi, Radix Inulae, Caesalpinia milettii Hook (et Arx), rescues temporarily, Eriosema himalaicum Ohashi, Ramulus et Folium Bischofiae Javanicae, Ainsliasa fragrans Champ and Potiria pectinifera (Mukller et Tro Sehel).
2. image diagnosis as claimed in claim 1 assists the Chinese medicine of video picture, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Hippopus hippopus (Linnaeus) 30 ~ 40 parts, Burmannia coelestis D. Don. 5 ~ 15 parts, grass imperial root 5 ~ 15 parts, wind and cold grass 10 ~ 20 parts, Placuna placenta (L.) 15 ~ 25 parts, Herba Clematidis tanguticae 5 ~ 15 parts, Radix Anemones Rivularis 10 ~ 20 parts, Justicia procumbens linn. 10 ~ 20 parts, Rhizoma Belamcandae 30 ~ 40 parts, osmanthus wood root 15 ~ 25 parts, Fructus Gomphocarpi futicosi 15 ~ 25 parts, Radix Inulae 5 ~ 15 parts, Caesalpinia milettii Hook (et Arx) 10 ~ 20 parts, rescue 15 ~ 25 parts temporarily, Eriosema himalaicum Ohashi 30 ~ 40 parts, Ramulus et Folium Bischofiae Javanicae 5 ~ 15 parts, Ainsliasa fragrans Champ 15 ~ 25 parts and Potiria pectinifera (Mukller et Tro Sehel) 20 ~ 30 parts.
3. image diagnosis as claimed in claim 1 or 2 assists the Chinese medicine of video picture, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Hippopus hippopus (Linnaeus) 30 ~ 35 parts, Burmannia coelestis D. Don. 5 ~ 10 parts, grass imperial root 5 ~ 10 parts, wind and cold grass 10 ~ 15 parts, Placuna placenta (L.) 15 ~ 20 parts, Herba Clematidis tanguticae 5 ~ 10 parts, Radix Anemones Rivularis 10 ~ 15 parts, Justicia procumbens linn. 10 ~ 15 parts, Rhizoma Belamcandae 30 ~ 35 parts, osmanthus wood root 15 ~ 20 parts, Fructus Gomphocarpi futicosi 15 ~ 20 parts, Radix Inulae 5 ~ 10 parts, Caesalpinia milettii Hook (et Arx) 10 ~ 15 parts, rescue 15 ~ 20 parts temporarily, Eriosema himalaicum Ohashi 30 ~ 35 parts, Ramulus et Folium Bischofiae Javanicae 5 ~ 10 parts, Ainsliasa fragrans Champ 15 ~ 20 parts and Potiria pectinifera (Mukller et Tro Sehel) 25 ~ 30 parts.
4. the image diagnosis as described in claims 1 to 3 assists the Chinese medicine of video picture, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Hippopus hippopus (Linnaeus) 32 parts, Burmannia coelestis D. Don. 7 parts, grass imperial root 8 parts, wind and cold grass 13 parts, Placuna placenta (L.) 18 parts, Herba Clematidis tanguticae 7 parts, Radix Anemones Rivularis 11 parts, Justicia procumbens linn. 14 parts, Rhizoma Belamcandae 34 parts, osmanthus wood root 16 parts, Fructus Gomphocarpi futicosi 18 parts, Radix Inulae 6 parts, Caesalpinia milettii Hook (et Arx) 11 parts, rescues 20 parts temporarily, Eriosema himalaicum Ohashi 32 parts, Ramulus et Folium Bischofiae Javanicae 5 parts, Ainsliasa fragrans Champ 16 parts and Potiria pectinifera (Mukller et Tro Sehel) 26 parts.
5. the image diagnosis as described in Claims 1-4 assists the Chinese medicine of video picture, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Hippopus hippopus (Linnaeus) 35 parts, Burmannia coelestis D. Don. 5 parts, careless imperial root 5 parts, wind and cold grass 10 parts, Placuna placenta (L.) 16 parts, Herba Clematidis tanguticae 10 parts, Radix Anemones Rivularis 15 parts, Justicia procumbens linn. 10 parts, Rhizoma Belamcandae 30 parts, osmanthus wood root 20 parts, Fructus Gomphocarpi futicosi 15 parts, Radix Inulae 10 parts, Caesalpinia milettii Hook (et Arx) 15 parts, rescues 15 parts temporarily, Eriosema himalaicum Ohashi 35 parts, Ramulus et Folium Bischofiae Javanicae 10 parts, Ainsliasa fragrans Champ 20 parts and Potiria pectinifera (Mukller et Tro Sehel) 29 parts.
6. the image diagnosis as described in claim 1 to 5 assists the Chinese medicine of video picture, it is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
7. the image diagnosis as described in claim 1 to 5 assists the Chinese medicine of video picture, it is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 DEG C ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 DEG C ~ 175 DEG C, leaving air temp 80 DEG C ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 DEG C ~ 50 DEG C dryings, obtains granule.
8. the image diagnosis as described in claim 1 to 5 assists a preparation method for the Chinese medicine of video picture, it is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
9. the image diagnosis as described in claim 1 to 5 assists a preparation method for the Chinese medicine of video picture, it is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 DEG C ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 DEG C ~ 175 DEG C, leaving air temp 80 DEG C ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 DEG C ~ 50 DEG C dryings, obtains granule.
CN201510354970.6A 2015-06-24 2015-06-24 Imaging-assisting traditional Chinese medicine for imaging diagnosis and preparation method thereof Pending CN104971367A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102068707A (en) * 2011-01-10 2011-05-25 张洪英 Traditional Chinese medicine contrast medium adjuvant used for B ultrasonic and preparation method thereof
CN102949734A (en) * 2012-09-18 2013-03-06 王玉云 Traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102068707A (en) * 2011-01-10 2011-05-25 张洪英 Traditional Chinese medicine contrast medium adjuvant used for B ultrasonic and preparation method thereof
CN102949734A (en) * 2012-09-18 2013-03-06 王玉云 Traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic and preparation method thereof

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Application publication date: 20151014