CN104971279A - Externally used agent for treating beriberi and preparation method thereof - Google Patents
Externally used agent for treating beriberi and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an externally used agent for treating beriberi. The agent is prepared from the following main active pharmaceutical ingredients in parts by weight: 8-16 parts of sessile stemona root, 6-12 parts of simpleleaf shrub chastetree fruit, 11-17 parts of Taiwan beautyberry leaf, 9-15 parts of herb of white loosestrife, 12-18 parts of lalang grass rhizome, 7-14 parts of entada sten, 10-16 parts of common achyranthes herb, 8-12 parts of sarmentose pepper herb, 9-16 parts of leaf of betel pepper, 6-14 parts of pharbitis seed, 8-15 parts of tangerine leaf, 7-13 parts of roylean euphorbia, 9-12 parts of Jenkine dendrobium, 11-16 parts of lobed actinostemma herb and 8-13 parts of pummelo peel. Through summary of the clinical practice for many years, the agent has the functions of sterilization and detoxication and the functions of removing dampness and relieving itching and has obvious curative effects.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to external preparation for the treatment of beriberi and preparation method thereof.
Background technology
Beriberi is being commonly called as of tinea pedis, is the dermatosis that fungal infection causes, has infectiousness.In China, the sickness rate of tinea pedis is also quite high.Do not have sebaceous gland between the vola of people and toe, thus lack the fatty acid suppressing skin filamentous fungi, physiological defense function is poor, and the sweat gland of skin at these positions is very abundant, perspire many, poor, the locally damp warm of air circulation, is conducive to the growth of filamentous fungi in addition.In addition, vola area skin horny layer is thicker, and the keratin in horny layer is the abundant nutrition material of fungus, is conducive to the growth of fungus.Its skin lesion is first one-sided (i.e. single foot) generation often, just infects to offside after several weeks or several months.Vesicle mainly appears at toe abdomen and toe side, and be most commonly between three or four toes, vola also can occur, for dark in property phlysis, can be fused into bulla gradually.The skin lesion of tinea pedis has a feature, i.e. clear border, can gradually to external expansion.Because of PD or scratch, erosion, sepage can be there is, even bacteriological infection, occur pustule etc.
Publication No. CN 104173872 A(application number 201410436148.X) Chinese patent literature disclose a kind of Chinese medicine for the treatment of beriberi, each Ingredients Weight of composition is: Realgar 10g, Alumen 15g, Radix Saposhnikoviae 20g, vinegar 15g, Bulbus Allii 10g, Radix Stemonae 10g, Borneolum Syntheticum 15g and ethanol 100g.Publication No. CN 104666404 A(application number 201310642394.6) Chinese patent literature disclose a kind of Chinese medicine being used for the treatment of beriberi, it is made up of the raw material of following parts by weight: Flos Carthami 2-10, Radix Sophorae Flavescentis 1-5, Alumen 1-3, iodine tincture 5-10, salt 1-5.Publication No. CN 103735652 A(application number 201410000161.0) Chinese patent literature disclose a kind of Chinese medicine for the treatment of beriberi, be made up of the raw material of following weight proportion: Rhizoma Coptidis 10-20, Radix Sophorae Flavescentis 10-15, Radix Saposhnikoviae 5-10, Radix Scutellariae 5-15, Cortex Acanthopancis 4-10, Rhizoma Chuanxiong 3-8.Described Chinese medicine can also add Radix Cynanchi Paniculati, Semen Ricini.
The medicament categories being used for the treatment of beriberi at present is on the market various, and therapeutic effect is very different, and some drugs can only play the effect of alleviation mostly, can not treat at all, therefore needs to develop a kind of instant effect, recoverable Chinese medicine formula.
Summary of the invention
For the problem of prior art, the object of this invention is to provide external preparation of the wide treatment beriberi of a kind of Be very effective, the use safety suitability and preparation method thereof.
Technical scheme of the present invention is:
The external preparation for the treatment of beriberi, is prepared from primarily of following bulk drugs, is mass parts: Radix Stemonae 8-16; Fructus Viticis 6-12; Folium Callicarpae Formosanae 11-17; Herba Lysimachiae Candidae 9-15; Rhizoma Imperatae 12-18; Semen Entadae 7-14; Radix achyranthis asperae (Herba Achyranthis Asperae) 10-16; Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 8-12; Folium piperis betlis 9-16; Semen Pharbitidis 6-14; Folium Citri tangerinae 8-15; Euphorbia royleana Boiss. 7-13; Dendrobium jenkinsii Wall ex Lindl． 9-12; Lobed Actinostemma Herb 11-16; Exocarpium Citri Grandis 8-13.
Preferred version is, Radix Stemonae 10-14; Fructus Viticis 8-10; Folium Callicarpae Formosanae 13-15; Herba Lysimachiae Candidae 11-13; Rhizoma Imperatae 14-16; Semen Entadae 9-12; Radix achyranthis asperae (Herba Achyranthis Asperae) 12-14; Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 9-11; Folium piperis betlis 11-14; Semen Pharbitidis 8-12; Folium Citri tangerinae 10-13; Euphorbia royleana Boiss. 9-11; Dendrobium jenkinsii Wall ex Lindl． 10-11; Lobed Actinostemma Herb 12-15; Exocarpium Citri Grandis 9-12.
More preferably, the Radix Stemonae 12; Fructus Viticis 9; Folium Callicarpae Formosanae 14; Herba Lysimachiae Candidae 12; Rhizoma Imperatae 15; Semen Entadae 10.5; Radix achyranthis asperae (Herba Achyranthis Asperae) 13; Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 10; Folium piperis betlis 12.5; Semen Pharbitidis 10; Folium Citri tangerinae 11.5; Euphorbia royleana Boiss. 10; Dendrobium jenkinsii Wall ex Lindl． 10.5; Lobed Actinostemma Herb 13.5; Exocarpium Citri Grandis 10.5.
The preparation method of the external preparation of described treatment beriberi, step is as follows:
(1) get Fructus Viticis, Semen Entadae and Semen Pharbitidis picks up clean impurity, be placed in frying pan, moderate heat heats, stir-fry to surperficial zoom, drench into crude drug quality 0.2-0.4 brown sugar water doubly (preferred: to drench the brown sugar water into crude drug 0.3 times), after moistening, continue to fry and be sucked to sucrose solution, taking-up cools;
(2) get Folium Callicarpae Formosanae, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Folium piperis betlis and Folium Citri tangerinae roguing to clean, be placed in container, water proof micro-steamings 5-15 minute (preferably: water proof micro-steaming 8-12 minute; Be more preferably: the micro-steaming of water proof 10 minutes), take out, be cut into filament, add refined honey and mix thoroughly, infiltrate hereinafter fire drying;
(3) Radix Stemonae, Herba Lysimachiae Candidae, Rhizoma Imperatae, Radix achyranthis asperae (Herba Achyranthis Asperae), Euphorbia royleana Boiss., Dendrobium jenkinsii Wall ex Lindl． and Lobed Actinostemma Herb are cleaned, be placed in steamer, slightly steam 10-18 minute (preferably: slightly steam 12-16 minute; Be more preferably: slightly steam 14 minutes), take out, shredding decocts with water twice together with step (1) (2) made crude drug, after filtration, merges twice gained filtrate;
(4) Exocarpium Citri Grandis is cleaned, be placed in oil cauldron, constantly stir, explode and turn yellow to surface, take out, drain oil, pulverize and sieve after cooling;
(5) blend step (3) (4) gained filtrate and medicated powder, stir, and heating is concentrated into the half of original volume, obtains external preparation.
The preparation method of the external preparation of described treatment beriberi, step (1) moistening 8-16 minute is (preferred: moistening 10-14 minute; Be more preferably: moistening 12 minutes).
The preparation method of the external preparation of described treatment beriberi, the amount that step (2) adds refined honey is the 0.3-0.5 of crude drug quality doubly (preferred: the amount adding refined honey is 0.4 times of crude drug quality).
The preparation method of the external preparation of described treatment beriberi, the 7-10 that step (3) amount of water is boiled crude drug quality is doubly (preferred: the 8-9 that amount of water is boiled crude drug quality is doubly; Be more preferably: amount of water is 8.5 times of boiled crude drug quality).
The preparation method of the external preparation of described treatment beriberi, each decocting time of step (3) be 28-36 minute (preferred: each decocting time is 30-34 minute; Be more preferably: each decocting time is 32 minutes).
The preparation method of the external preparation of described treatment beriberi, it is (preferred: to pulverize 160-200 mesh sieve that step (4) pulverized 140-220 mesh sieve; Be more preferably: pulverized 180 mesh sieves).
Present invention also offers the application of external preparation when preparing treatment beriberi of described treatment beriberi.
The external preparation scientific formulation for the treatment of beriberi provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, determined curative effect of the present invention, for Chinese medicine material is made, without obvious toxic-side effects;
2, this prescription is according to Chinese medicine principle, has the effect such as disinfecting detoxifying, removing damp to relieve itching;
3, relapse rate of the present invention is low, short treating period, lasting medicine, thoroughly can effect a radical cure beriberi.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the external preparation for the treatment of beriberi, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Stemonae 8 parts, Fructus Viticis 6 parts, Folium Callicarpae Formosanae 11 parts, Herba Lysimachiae Candidae 9 parts, Rhizoma Imperatae 12 parts of Semen Entadae 7 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 10 parts of ， Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 8 parts of Folium piperis betliss 9 parts, Semen Pharbitidis 6 parts, Folium Citri tangerinae 8 parts, Euphorbia royleana Boiss. 7 parts, Dendrobium jenkinsii Wall ex Lindl． 9 parts, Lobed Actinostemma Herb 11 parts, Exocarpium Citri Grandis 8 parts.The preparation method of the external preparation of above-mentioned treatment beriberi is:
(1) get Fructus Viticis, Semen Entadae and Semen Pharbitidis picks up clean impurity, be placed in frying pan, moderate heat heats, and stir-fries to surperficial zoom, drenches the brown sugar water into crude drug quality 0.2 times, and moistening is after 8 minutes, continues to fry to be sucked to sucrose solution, and taking-up cools;
(2) get Folium Callicarpae Formosanae, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Folium piperis betlis and Folium Citri tangerinae roguing to clean, be placed in container, the micro-steaming of water proof 5 minutes, take out, be cut into filament, the refined honey adding crude drug quality 0.3 times is mixed thoroughly, infiltrates hereinafter fire drying;
(3) Radix Stemonae, Herba Lysimachiae Candidae, Rhizoma Imperatae, Radix achyranthis asperae (Herba Achyranthis Asperae), Euphorbia royleana Boiss., Dendrobium jenkinsii Wall ex Lindl． and Lobed Actinostemma Herb are cleaned, be placed in steamer, slightly steam 10 minutes, take out, shredding decocts with water twice (amount of water is 7 times of boiled crude drug quality) together with step (1) (2) made crude drug, each decocting time is 28 minutes, after filtration, merges twice gained filtrate;
(4) Exocarpium Citri Grandis is cleaned, be placed in oil cauldron, constantly stir, explode and turn yellow to surface, take out, drain oil, after cooling, pulverized 140 mesh sieves;
(5) blend step (3) (4) gained filtrate and medicated powder, stir, and heating is concentrated into the half of original volume, obtains external preparation.
embodiment 2the external preparation for the treatment of beriberi, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Stemonae 16 parts, Fructus Viticis 12 parts, Folium Callicarpae Formosanae 17 parts, Herba Lysimachiae Candidae 15 parts, Rhizoma Imperatae 18 parts of Semen Entadae 14 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 16 parts of ， Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 12 parts of Folium piperis betliss 16 parts, Semen Pharbitidis 14 parts, Folium Citri tangerinae 15 parts, Euphorbia royleana Boiss. 13 parts, Dendrobium jenkinsii Wall ex Lindl． 12 parts, Lobed Actinostemma Herb 16 parts, Exocarpium Citri Grandis 13 parts.The preparation method of the external preparation of above-mentioned treatment beriberi is:
(1) get Fructus Viticis, Semen Entadae and Semen Pharbitidis picks up clean impurity, be placed in frying pan, moderate heat heats, and stir-fries to surperficial zoom, drenches the brown sugar water into crude drug quality 0.4 times, and moistening is after 16 minutes, continues to fry to be sucked to sucrose solution, and taking-up cools;
(2) get Folium Callicarpae Formosanae, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Folium piperis betlis and Folium Citri tangerinae roguing to clean, be placed in container, the micro-steaming of water proof 15 minutes, take out, be cut into filament, the refined honey adding crude drug quality 0.5 times is mixed thoroughly, infiltrates hereinafter fire drying;
(3) Radix Stemonae, Herba Lysimachiae Candidae, Rhizoma Imperatae, Radix achyranthis asperae (Herba Achyranthis Asperae), Euphorbia royleana Boiss., Dendrobium jenkinsii Wall ex Lindl． and Lobed Actinostemma Herb are cleaned, be placed in steamer, slightly steam 18 minutes, take out, shredding decocts with water twice (amount of water is 10 times of boiled crude drug quality) together with step (1) (2) made crude drug, each decocting time is 36 minutes, after filtration, merges twice gained filtrate;
(4) Exocarpium Citri Grandis is cleaned, be placed in oil cauldron, constantly stir, explode and turn yellow to surface, take out, drain oil, after cooling, pulverized 220 mesh sieves;
(5) blend step (3) (4) gained filtrate and medicated powder, stir, and heating is concentrated into the half of original volume, obtains external preparation.
Model case: xxx, male, 23 years old.Medical history: patient when half a year works in front building site, catches beriberi, long adularescent vesicle in little toe space during beginning, pruritus, after spread to whole toe space gradually, in syringe needle size, there is decortication phenomenon, foot odor after perspiring, festers, and scratching pruritus is without alleviating, after using some drugs, Relapse rate shows effect, and patient is deeply bitter by it, finds tcm methods treatment.
Use this example gained external preparation, be applied in affected part, one day 2-4 time, within five days, be a course for the treatment of, after patient uses three days, pruritis is obviously alleviated, and after adhering to two courses for the treatment of of use, vesicle turns for the better by and large, and skin recovers normal, and after consolidating a course for the treatment of, patient fully recovers.
embodiment 3the external preparation for the treatment of beriberi, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Stemonae 10 parts, Fructus Viticis 8 parts, Folium Callicarpae Formosanae 13 parts, Herba Lysimachiae Candidae 11 parts, Rhizoma Imperatae 14 parts of Semen Entadae 9 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 12 parts of ， Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 9 parts of Folium piperis betliss 11 parts, Semen Pharbitidis 8 parts, Folium Citri tangerinae 10 parts, Euphorbia royleana Boiss. 9 parts, Dendrobium jenkinsii Wall ex Lindl． 10 parts, Lobed Actinostemma Herb 12 parts, Exocarpium Citri Grandis 9 parts.The preparation method of the external preparation of above-mentioned treatment beriberi is:
(1) get Fructus Viticis, Semen Entadae and Semen Pharbitidis picks up clean impurity, be placed in frying pan, moderate heat heats, and stir-fries to surperficial zoom, drenches the brown sugar water into crude drug quality 0.2 times, and moistening is after 10 minutes, continues to fry to be sucked to sucrose solution, and taking-up cools;
(2) get Folium Callicarpae Formosanae, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Folium piperis betlis and Folium Citri tangerinae roguing to clean, be placed in container, the micro-steaming of water proof 8 minutes, take out, be cut into filament, the refined honey adding crude drug quality 0.3 times is mixed thoroughly, infiltrates hereinafter fire drying;
(3) Radix Stemonae, Herba Lysimachiae Candidae, Rhizoma Imperatae, Radix achyranthis asperae (Herba Achyranthis Asperae), Euphorbia royleana Boiss., Dendrobium jenkinsii Wall ex Lindl． and Lobed Actinostemma Herb are cleaned, be placed in steamer, slightly steam 12 minutes, take out, shredding decocts with water twice (amount of water is 8 times of boiled crude drug quality) together with step (1) (2) made crude drug, each decocting time is 30 minutes, after filtration, merges twice gained filtrate;
(4) Exocarpium Citri Grandis is cleaned, be placed in oil cauldron, constantly stir, explode and turn yellow to surface, take out, drain oil, after cooling, pulverized 160 mesh sieves;
(5) blend step (3) (4) gained filtrate and medicated powder, stir, and heating is concentrated into the half of original volume, obtains external preparation.
embodiment 4the external preparation for the treatment of beriberi, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Stemonae 14 parts, Fructus Viticis 10 parts, Folium Callicarpae Formosanae 15 parts, Herba Lysimachiae Candidae 13 parts, Rhizoma Imperatae 16 parts of Semen Entadae 12 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 14 parts of ， Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 11 parts of Folium piperis betliss 14 parts, Semen Pharbitidis 12 parts, Folium Citri tangerinae 13 parts, Euphorbia royleana Boiss. 11 parts, Dendrobium jenkinsii Wall ex Lindl． 11 parts, Lobed Actinostemma Herb 15 parts, Exocarpium Citri Grandis 12 parts.The preparation method of the external preparation of above-mentioned treatment beriberi is:
(1) get Fructus Viticis, Semen Entadae and Semen Pharbitidis picks up clean impurity, be placed in frying pan, moderate heat heats, and stir-fries to surperficial zoom, drenches the brown sugar water into crude drug quality 0.4 times, and moistening is after 14 minutes, continues to fry to be sucked to sucrose solution, and taking-up cools;
(2) get Folium Callicarpae Formosanae, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Folium piperis betlis and Folium Citri tangerinae roguing to clean, be placed in container, the micro-steaming of water proof 12 minutes, take out, be cut into filament, the refined honey adding crude drug quality 0.5 times is mixed thoroughly, infiltrates hereinafter fire drying;
(3) Radix Stemonae, Herba Lysimachiae Candidae, Rhizoma Imperatae, Radix achyranthis asperae (Herba Achyranthis Asperae), Euphorbia royleana Boiss., Dendrobium jenkinsii Wall ex Lindl． and Lobed Actinostemma Herb are cleaned, be placed in steamer, slightly steam 16 minutes, take out, shredding decocts with water twice (amount of water is 9 times of boiled crude drug quality) together with step (1) (2) made crude drug, each decocting time is 34 minutes, after filtration, merges twice gained filtrate;
(4) Exocarpium Citri Grandis is cleaned, be placed in oil cauldron, constantly stir, explode and turn yellow to surface, take out, drain oil, after cooling, pulverized 200 mesh sieves;
(5) blend step (3) (4) gained filtrate and medicated powder, stir, and heating is concentrated into the half of original volume, obtains external preparation.
Model case: xxx, women, 36 years old.Main suit: have vesicle between foot odor, pruritus, toe space; Medical history: patient is before three months, and Tu Gan foot pruritus, finds there is vesicle in two toe space, distribute in groups, pressing without pain, after spread gradually, mutually merge and form large vesicle, acute pruritus, after peeling, visible honeycomb substrate and the rotten to the corn face of cerise, be diagnosed as vesicle beriberi.
Through this example of recommendation gained external preparation, being applied in affected part, one day 2-4 time, five days is a course for the treatment of, after patient uses a course for the treatment of, uncomfortable disease is taken a turn for the better gradually, and after continuing two courses for the treatment of of use, patient's beriberi is eliminated, without other uncomfortable diseases, follow up a case by regular visits to after 1 year, without recurrence.
embodiment 5the external preparation for the treatment of beriberi, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Stemonae 12 parts, Fructus Viticis 9 parts, Folium Callicarpae Formosanae 14 parts, Herba Lysimachiae Candidae 12 parts, Rhizoma Imperatae 15 parts of Semen Entadae 10.5 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 13 parts of ， Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 10 parts of Folium piperis betliss 12.5 parts, Semen Pharbitidis 10 parts, Folium Citri tangerinae 11.5 parts, Euphorbia royleana Boiss. 10 parts, Dendrobium jenkinsii Wall ex Lindl． 10.5 parts, Lobed Actinostemma Herb 13.5 parts, Exocarpium Citri Grandis 10.5 parts.The preparation method of the external preparation of above-mentioned treatment beriberi is:
(1) get Fructus Viticis, Semen Entadae and Semen Pharbitidis picks up clean impurity, be placed in frying pan, moderate heat heats, and stir-fries to surperficial zoom, drenches the brown sugar water into crude drug quality 0.3 times, and moistening is after 12 minutes, continues to fry to be sucked to sucrose solution, and taking-up cools;
(2) get Folium Callicarpae Formosanae, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Folium piperis betlis and Folium Citri tangerinae roguing to clean, be placed in container, the micro-steaming of water proof 10 minutes, take out, be cut into filament, the refined honey adding crude drug quality 0.4 times is mixed thoroughly, infiltrates hereinafter fire drying;
(3) Radix Stemonae, Herba Lysimachiae Candidae, Rhizoma Imperatae, Radix achyranthis asperae (Herba Achyranthis Asperae), Euphorbia royleana Boiss., Dendrobium jenkinsii Wall ex Lindl． and Lobed Actinostemma Herb are cleaned, be placed in steamer, slightly steam 14 minutes, take out, shredding decocts with water twice (amount of water is 8.5 times of boiled crude drug quality) together with step (1) (2) made crude drug, each decocting time is 32 minutes, after filtration, merges twice gained filtrate;
(4) Exocarpium Citri Grandis is cleaned, be placed in oil cauldron, constantly stir, explode and turn yellow to surface, take out, drain oil, after cooling, pulverized 180 mesh sieves;
(5) blend step (3) (4) gained filtrate and medicated powder, stir, and heating is concentrated into the half of original volume, obtains external preparation.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
The Radix Stemonae: base is former: be the tuber of Stemonaceae plant Radix stemonae japonicae, Radix Stemonae or radix stemonae tuberosae etc.Nature and flavor: sweetness and bitterness, tepor.Gui Jing: enter lung meridian.Function cures mainly: gentle lung qi, cough-relieving, parasite killing.Control cough due to wind and cold, pertussis, pulmonary tuberculosis, old cough with asthma, ascarid, enterobiasis, skin scabies, eczema.
Fructus Viticis: base is former: be the fruit of Verbenaceae Vitex rotundifolia or wild pepper.Nature and flavor: pungent, bitter, are slightly cold.Return bladder, liver, stomach warp.There is dispelling wind and heat pathogens, effect of the clear sharp head.For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.
Folium Callicarpae Formosanae: base is former: be the leaf of dicotyledon medicine Verbenaceae callicarpa pedunculata, Callicarpa dichotoma, callicarpa cathayana Chang, Radix Callicarpae Giraldii.Nature and flavor: pained; Cool.Function cures mainly: astringing to arrest bleeding; Heat-clearing and toxic substances removing.Main hematemesis; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Gingival hemorrhage; Metrorrhagia; Skin purpura; Traumatic hemorrhage; Swollen ulcer drug; Venom; Burn.
Herba Lysimachiae Candidae: base is former: be herb or the root of Ofthe Primulaceae pool Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis).Nature and flavor: bitter; Cool in nature.Gui Jing: spleen; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain; Li Wen subsides a swelling.Main laryngopharynx swelling and pain; Carbuncle sore tumefacting virus; Acute mastitis; Venom; Injury and bone fracture; Rheumatic arthralgia; Beriberi.
Rhizoma Imperatae: nature and flavor with return through: sweet, cold.Return lung, stomach, urinary bladder channel.There is cooling blood for hemostasis, effect of clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice due to damp-heat, edema oliguria, the puckery pain of pyretic stranguria.
Semen Entadae: base is former: be the seed of Dou section Zhi Wu Semen Entadae.Nature and flavor: puckery sweet; Flat; Nontoxic.Gui Jing: stomach; Liver; Large intestine channel.Function cures mainly: promoting the circulation of QI to relieve pain, inducing diuresis and reducing edema.Main abdominal distention, jaundice, beriberi edema, dysentery, hemorrhoid, proctoptosis, sore throat.
Radix achyranthis asperae (Herba Achyranthis Asperae): base is former: be the herb of amaranthaceous plant coarse wool Radix Achyranthis Bidentatae.Nature and flavor: bitter; Acid; Cold nature.Gui Jing: liver; Lung; Urinary bladder channel.Function cures mainly: blood circulation promoting and blood stasis dispelling; Inducing diuresis for treating stranguria syndrome; Clearing away heat and expelling pathogen in the exterior.Main warp closes; Dysmenorrhea; Menoxenia; Traumatic injury; Rheumatic arthritis; Gonorrhea; Edema; Damp-heat vaginal discharge, fever caused by exogenous pathogens; Malaria; Pharyngalgia; Furuncle carbuncle.
Radix Piperis sarmentosi (Herba Piperis Sarmentosi): base is former: be the stem of Piperaceae plant Radix Piperis sarmentosi (Herba Piperis Sarmentosi), leaf or herb.Nature and flavor: bitter; Warm in nature.Gui Jing: the heart; Lung; Spleen; Large intestine channel.Function cures mainly: expelling wind and cold; Promoting the circulation of QI to relieve pain; Active; Detumescence.Main air is trembled with fear cough with asthma; Rheumatic arthralgia; Distension and fullness in the abdomen; Dysentery; Puerperal swelling of the feet; Traumatic injury.
Folium piperis betlis: base is former: be the leaf of Piperaceae Zhi Wu Spica piperis betlis.Nature and flavor: pungent; Temperature.Gui Jing: lung; Stomach warp.Function cures mainly: expelling wind and cold, promoting the circulation of QI and reducing phlegm, removing toxic substances and promoting subsidence of swelling, dampness removing to stop itchin.Main cough due to wind and cold, asthma, pertussis, institute's abdominal distention and pain, dyspepsia is indigestion and loss of appetite, edema, and traumatic injury wound is swollen, and rheumatic ostalgia, sore swollen toxin, swelling and pain of hemorrhoid, burn, pathogenic wind-toxic beriberi, mange, eczema epidemic disease is itched.
Semen Pharbitidis: base is former: for dicotyledon scammonia section plant is led a cow or the seed of pharbitis hispida etc.Nature and flavor: toil; Cold.Gui Jing: lung; Kidney; Large intestine; Small intestine meridian.Function cures mainly: diuretic relieving constipation; Eliminate the phlegm by drink; Eliminating stagnated food and killing intestinal worms.Main edema; Ascites; Foot gas; Expectorant heap soil or fertilizer over and around the roots is breathed with cough; Constipation; Dyspepsia malnutrition due to parasitic infestation; Lumbago; Scrotal swelling; Swollen ulcer drug; Anal fistula inguinal bubo etc.
Folium Citri tangerinae: base is former: this product is the leaf of the multiple Fructus Citri tangerinae class such as leaf or Zhu's Fructus Citri tangerinae of rutaceae orange, can adopt at any time, dry or using fresh herb.Chemical composition: containing vitamin C in leaf.Another containing multiple kinds of carbohydrate, as glucose, fructose, sucrose, starch and cellulose etc., its content is higher when blooming, decrescence few during fruit maturation, increases again after harvesting.Various Folium Citri tangerinae is all containing volatile oil.Containing vitamin c 151 milligrams of % in the leaf of citrus reticulata“Unshiu”.Nature and flavor with return through toil, flat.Enter Liver Channel.Have soothing the liver, circulation of qi promoting, reduce phlegm, effect of detumescence poison.Cure mainly hypochondriac pain, acute mastitis, lung abscess, cough, chest and diaphragm feeling of fullness, hernia.
Euphorbia royleana Boiss.: base is former: be the Herb of euphorbia plant Euphorbia royleana Boiss..Nature and flavor: pained; Flat; Poisonous.Gui Jing: the heart; Spleen channel.Function cures mainly: removing toxic substances of dispeling the wind; Killing parasites for relieving itching.Main sore swollen toxin; Psoriasis.
Dendrobium jenkinsii Wall ex Lindl．: base is former: for the orchid family Dendrobium Sw gathers the herb of Herba Dendrobii.The property of medicine: liver, gallbladder is cool.Function cures mainly: nourishing the lung to arrest cough, tonifying-Yin and nourishing-stomach.Cure mainly cough due to lung-heat, pulmonary tuberculosis, asthma, dysentery, stomatitis, stomachache, infant malnutrition.
Lobed Actinostemma Herb: base is former: be herb or the seed of Cucurbitaceae Lobed Actinostemma Herb platymiscium Lobed Actinostemma Herb.The property of medicine: bitter, cold.Function cures mainly: inducing diuresis to remove edema, heat-clearing and toxic substances removing.Cure mainly edema, tympanites, infantile malnutrition, eczema, skin infection, venom.
Exocarpium Citri Grandis: base is former: be the outside rind of the immature fruit of Rutaceae plant Citrus grandis or Fructus Citri grandis.Chemical analysis: fruit is containing naringin, naringin unit; Peel is containing citral, geraniol, linalool, phosphorus Methyl anthranilate etc.Nature and flavor: bitter; Pungent; Temperature.Gui Jing: spleen; Lung meridian.Drying dampness to eliminate phlegm; Regulate the flow of vital energy; Help digestion.Main air is trembled with fear cough with asthma abundant expectoration; Vomiting singultus; Accumulation of food in the stomach and intes tine due to indigestion; Abdominal distention.
test example 1the clinical practice of the external preparation (embodiment 5) of gained treatment beriberi of the present invention:
Choose crowd: in March ,-2015 in April, 2014, according to medical case history, have typical beriberi symptom five hospital's screenings, fungus microscope examination is positive patient 265 example, male patient 143 example, female patient 122 example, age 10-65 year, 37.9 ± 2.8 years old mean age, the course of disease 3 months-10 years, wherein vesicle beriberi patient 96 example, erosive beriberi patient 88 example, squama keratinization type beriberi patient 81 example.All patients did not use antifungal medicine in two weeks, got rid of gestation and nursing women, diabetes and severe cardiac Liver and kidney patient, and treatments period patient needs further consultation on time.
Before test, patient is divided into two groups at random, experimental group 165 example and matched group 100 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group uses products obtained therefrom of the present invention, is applied in affected part, one day 2-4 time, within five days, is a course for the treatment of; Matched group uses other conventional medicines (daktarin, beriberi king, ZUGUANG SAN etc.).Treatments period carries out Continuous Observation to two groups of patients, record symptom (pimple, vesicle, desquamation, pruritus, chap) improvement situation, onset time and having no adverse reaction.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: clinical symptom disappearance, and skin lesion recovers, and fungus microscope examination is negative; (2) take a turn for the better: clinical symptoms is obviously alleviated, skin lesion part is recovered, and fungus microscope examination is positive (visible a small amount of mycelia); (3) invalid: clinical symptoms and microscopy are substantially without improvement.
Clinical effectiveness: after the treatment of three courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
As shown in Table 1, the healing patient of experimental group is 119 examples, and cure rate is 72.1%, improvement patient is 43 examples, and improvement rate is 26.1%, and total effective rate is 98.2%, and the patient that matched group is cured is 56 examples, cure rate is 56.0%, and the patient of improvement is 25 examples, and improvement rate is 25.0%, total effective rate 81.0%, significantly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.
The Chinese medicine used in the present invention, comprise the Radix Stemonae of gentle lung qi, the Fructus Viticis of dispelling wind and heat pathogens, the Folium Callicarpae Formosanae of heat-clearing and toxic substances removing, Lobed Actinostemma Herb, the Herba Lysimachiae Candidae of promoting blood circulation and stopping pain, the Rhizoma Imperatae of cooling blood for hemostasis, inducing diuresis and reducing edema Semen Entadae, the Radix achyranthis asperae (Herba Achyranthis Asperae) of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain Radix Piperis sarmentosi (Herba Piperis Sarmentosi), dampness removing to stop itchin Folium piperis betlis, Exocarpium Citri Grandis, the Semen Pharbitidis of diuretic relieving constipation, the Folium Citri tangerinae of subduing swelling and detoxicating, the Euphorbia royleana Boiss. of killing parasites for relieving itching, the Dendrobium jenkinsii Wall ex Lindl． of tonifying-Yin and nourishing-stomach, all medicines share, and have effectively given play to effect of dampness removing to stop itchin, heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the external preparation of beriberi, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Radix Stemonae 8-16; Fructus Viticis 6-12; Folium Callicarpae Formosanae 11-17; Herba Lysimachiae Candidae 9-15; Rhizoma Imperatae 12-18; Semen Entadae 7-14; Radix achyranthis asperae (Herba Achyranthis Asperae) 10-16; Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 8-12; Folium piperis betlis 9-16; Semen Pharbitidis 6-14; Folium Citri tangerinae 8-15; Euphorbia royleana Boiss. 7-13; Dendrobium jenkinsii Wall ex Lindl． 9-12; Lobed Actinostemma Herb 11-16; Exocarpium Citri Grandis 8-13.
2. the external preparation for the treatment of beriberi as claimed in claim 1, is characterized in that, Radix Stemonae 10-14; Fructus Viticis 8-10; Folium Callicarpae Formosanae 13-15; Herba Lysimachiae Candidae 11-13; Rhizoma Imperatae 14-16; Semen Entadae 9-12; Radix achyranthis asperae (Herba Achyranthis Asperae) 12-14; Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 9-11; Folium piperis betlis 11-14; Semen Pharbitidis 8-12; Folium Citri tangerinae 10-13; Euphorbia royleana Boiss. 9-11; Dendrobium jenkinsii Wall ex Lindl． 10-11; Lobed Actinostemma Herb 12-15; Exocarpium Citri Grandis 9-12.
3. the external preparation for the treatment of beriberi as claimed in claim 1, is characterized in that, the Radix Stemonae 12; Fructus Viticis 9; Folium Callicarpae Formosanae 14; Herba Lysimachiae Candidae 12; Rhizoma Imperatae 15; Semen Entadae 10.5; Radix achyranthis asperae (Herba Achyranthis Asperae) 13; Radix Piperis sarmentosi (Herba Piperis Sarmentosi) 10; Folium piperis betlis 12.5; Semen Pharbitidis 10; Folium Citri tangerinae 11.5; Euphorbia royleana Boiss. 10; Dendrobium jenkinsii Wall ex Lindl． 10.5; Lobed Actinostemma Herb 13.5; Exocarpium Citri Grandis 10.5.
4. the preparation method of the external preparation of the treatment beriberi as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) get Fructus Viticis, Semen Entadae and Semen Pharbitidis picks up clean impurity, be placed in frying pan, moderate heat heats, stir-fry to surperficial zoom, drench into crude drug quality 0.2-0.4 brown sugar water doubly (preferred: to drench the brown sugar water into crude drug 0.3 times), after moistening, continue to fry and be sucked to sucrose solution, taking-up cools;
(2) get Folium Callicarpae Formosanae, Radix Piperis sarmentosi (Herba Piperis Sarmentosi), Folium piperis betlis and Folium Citri tangerinae roguing to clean, be placed in container, water proof micro-steamings 5-15 minute (preferably: water proof micro-steaming 8-12 minute; Be more preferably: the micro-steaming of water proof 10 minutes), take out, be cut into filament, add refined honey and mix thoroughly, infiltrate hereinafter fire drying;
(3) Radix Stemonae, Herba Lysimachiae Candidae, Rhizoma Imperatae, Radix achyranthis asperae (Herba Achyranthis Asperae), Euphorbia royleana Boiss., Dendrobium jenkinsii Wall ex Lindl． and Lobed Actinostemma Herb are cleaned, be placed in steamer, slightly steam 10-18 minute (preferably: slightly steam 12-16 minute; Be more preferably: slightly steam 14 minutes), take out, shredding decocts with water twice together with step (1) (2) made crude drug, after filtration, merges twice gained filtrate;
(4) Exocarpium Citri Grandis is cleaned, be placed in oil cauldron, constantly stir, explode and turn yellow to surface, take out, drain oil, pulverize and sieve after cooling;
(5) blend step (3) (4) gained filtrate and medicated powder, stir, and heating is concentrated into the half of original volume, obtains external preparation.
5. the preparation method of the external preparation for the treatment of beriberi as claimed in claim 4, is characterized in that, step (1) moistening 8-16 minute (preferred: moistening 10-14 minute; Be more preferably: moistening 12 minutes).
6. the preparation method of the external preparation for the treatment of beriberi as claimed in claim 4, is characterized in that, the amount that step (2) adds refined honey is the 0.3-0.5 of crude drug quality doubly (preferred: the amount adding refined honey is 0.4 times of crude drug quality).
7. the preparation method of the external preparation for the treatment of beriberi as claimed in claim 4, is characterized in that, the 7-10 that step (3) amount of water is boiled crude drug quality is doubly (preferred: the 8-9 that amount of water is boiled crude drug quality doubly; Be more preferably: amount of water is 8.5 times of boiled crude drug quality).
8. the preparation method of the external preparation for the treatment of beriberi as claimed in claim 4, is characterized in that, each decocting time of step (3) be 28-36 minute (preferred: each decocting time is 30-34 minute; Be more preferably: each decocting time is 32 minutes).
9. the preparation method of the external preparation for the treatment of beriberi as claimed in claim 4, it is characterized in that, it is (preferred: to pulverize 160-200 mesh sieve that step (4) pulverized 140-220 mesh sieve; Be more preferably: pulverized 180 mesh sieves).
10. the application of external preparation when preparing treatment beriberi of the treatment beriberi as described in as arbitrary in claim 1-3.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904998A (en) * | 2009-06-08 | 2010-12-08 | 罗兴富 | Special medicament for treating dermatophytosis and preparation method thereof |
| JP2014088334A (en) * | 2012-10-29 | 2014-05-15 | Sakamoto Yakuhin Kogyo Co Ltd | Athlete's foot medicine for external use |
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2015
- 2015-07-23 CN CN201510435376.XA patent/CN104971279A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904998A (en) * | 2009-06-08 | 2010-12-08 | 罗兴富 | Special medicament for treating dermatophytosis and preparation method thereof |
| JP2014088334A (en) * | 2012-10-29 | 2014-05-15 | Sakamoto Yakuhin Kogyo Co Ltd | Athlete's foot medicine for external use |
Non-Patent Citations (1)
| Title |
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| 王桂田等: "十味液洗剂治疗手足癣疗效观察", 《黑龙江中医药》 * |
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Address after: Qingshan District Baotou city 014000 National Road No. 2 the Inner Mongolia Autonomous Region District No. 4 Yingbin building 2-201 Applicant after: Hao Li Address before: Beiyuan Street Licheng District 250000 Shandong city of Ji'nan province No. 36 Applicant before: Hao Li |
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Application publication date: 20151014 |