CN104971182A - Traditional Chinese medicine composition for treating constipation - Google Patents
Traditional Chinese medicine composition for treating constipation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating constipation, and belongs to the technical field of a medicine for treating constipation. The traditional Chinese medicine composition is prepared from the following raw herbal materials, by weight part: 30-40 of rheum officinale, 45-60 of radix codonopsis, 30-40 of Chinese angelica, 15-20 of bighead atractylodes rhizome, 15-20 of radix astragali, 15-20 of pinellia ternate, 30-40 of immature orange fruit, 30-40 of magnolia cortex, 15-20 of dried orange peel, and 30-40 of senna leaf. The traditional Chinese medicine composition is scientific in compatibility, has the efficacy of clearing heat and moistening the intestines, relieving stuffiness and dispersing nodules, and boosting qi and nourishing blood, and has the efficacy of tonifying the kidney and boosting essence, nourishing yin and increasing humor, and moistening dryness and fortifying the spleen. The traditional Chinese medicine composition is a sustained release preparation, and the drug effect starts to be sustainably released after the traditional Chinese medicine composition enters the intestines. The traditional Chinese medicine composition can directly reach at a deep focus, adjusts the movement function of the stomach and intestines, and achieves the purpose of simultaneous treatment of principal and subordinate symptoms. The traditional Chinese medicine composition is good in curative effect without recrudesce, can be mildly administrated, has no side effect or drug dependence, and is particularly suitable for a patient, who suffers from constipation, is weak, and has an interior heat indigestion symptom.
Description
Technical field
The invention belongs to the technical field of the medicine for the treatment of constipation, refer to a kind of Chinese medicine composition for the treatment of constipation especially.
Background technology
Constipation is a kind of commonly encountered diseases, and it is caused by many reasons, and the traditional Chinese medical science is divided into according to different reason: dryness-heat stagnating in the interior type, depression and stagnation of QI type, deficiency of body fluid type, spleen-kidney vacuity cold type.The traditional Chinese medical science says that dryness-heat stagnating in the interior type is that enter inner heat-transformation, or epidemic febrile disease heresy enters gastrointestinal, intenseness of heat burns caused by Tianjin by passing the bright internal organs of sun in the heresy of typhoid fever.Knot in excess-heat, the gastrointestinal stagnation of QI, FU QI being obstructed, therefore constipation, frequently passing of flatus, gastral cavity abdomen feeling of fullness, abdominal pain with tenderness; Excessive heat in the interior, above disturbs gods, therefore delirium; Dry and yellowish fur plays thorn, or burned blackly cracks from dryness, and deep and forceful pulse is levying of intenseness of heat impairment of body fluid.Cold limbs due to intense heat in the interior, convulsive diseases, to go mad, all because tying in excess-heat, or mechanism of qi retardance, yang-energy is held back, and can not reach in extremity outward; Intenseness of heat muscle and tendon injury, muscle arteries and veins are lost foster and contraction is anxious; Or caused by gastrointestine dryness heat disturbing the mind upwards.
Apply cathartic preparation for the treatment of constipation at present, though energy relief of symptoms, its side effect even can increase the weight of comparatively greatly the intractable of constipation more.The medicine such as the many employings of doctor trained in Western medicine " phenolphthalein sugar ", " Kai Saitong " carries out treating and alleviating, and existence is cured the symptoms, not the disease, and cure rate is low, the defect of easily recurrence.The traditional Chinese medical science adopts " DACHENGQI TANG " to adopt the medicines such as Radix Et Rhizoma Rhei, Folium Sennae, magnesium sulfate to remove heat by catharsis, and its unsatisfactory curative effect, often recurs.
Summary of the invention
The invention provides a kind of Chinese medicine composition for the treatment of constipation, solve in prior art low, the easy recurrence of the cured substance rate for the treatment of constipation and the large problem of toxic and side effects.
A kind of Chinese medicine composition for the treatment of constipation of the present invention, it mainly realizes by the following technical programs so in addition: described Chinese medicine composition comprises the herbal raw material of following weight portion: Radix Et Rhizoma Rhei 30-40 part, Radix Codonopsis 45-60 part, Radix Angelicae Sinensis 30-40 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Astragali 15-20 part, Rhizoma Pinelliae 15-20 part, Fructus Aurantii Immaturus 30-40 part, Cortex Magnoliae Officinalis 30-40 part, Pericarpium Citri Reticulatae 15-20 part, Folium Sennae 30-40 part.
In Chinese medicine composition of the present invention, Radix Et Rhizoma Rhei purging heat to relax the bowels, cleanses the intestines and stomach, is monarch drug; Radix Codonopsis, Radix Astragali QI invigorating, in case rush down therapeutic method to keep the adverse QI flowing downwards holder, are ministerial drug; Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus promoting QI to circulate and dispersing the agglomeration of the pathogens, relieving distension and oppression, and help Radix Et Rhizoma Rhei to push away to swing stagnant with the excretion accelerating accumulation of heat, altogether for assistant makes.Various Chinese herbal medicine scientific compatibility, drug effect complement each other, bring out the best in each other, and have effect of clearing away heat and moistening the bowels, dissolving lump and resolving mass and benefiting QI and nourishing blood, through focus depths; And, can also immunity of organisms be improved, thus reach the object for the treatment of both the principal and secondary aspects of a disease, to the treatment of constipation, there is good effect, the constipation patient determined curative effect of excess syndrome that the empty interior-heat simultaneously of body is stagnated.
In Chinese medicine composition of the present invention, Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature; Return stomach, large intestine, liver, spleen channel; There is heat and toxic materials clearing away, eliminating fire and detoxication, blood circulation promoting and blood stasis dispelling, let out damp and hot effect clearly; Cure mainly excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, spits blood, spitting of blood, and epistaxis, has blood in stool, hematuria, blood-retention, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, scalds.
In Chinese medicine composition of the present invention, Radix Codonopsis: sweet in the mouth, property is put down; Return spleen, lung meridian; Have matter profit gas and, there is spleen invigorating lung benefiting, benefiting QI and nourishing blood, the effect of promoting the production of body fluid; Cure mainly weakness of the spleen and stomach, anorexia and loose stool, fatigue and weakness, the deficiency of the lung is breathed with cough, lazy speech of breathing hard, spontaneous perspiration, and blood deficiency and yellow complexion is thirsty.
In Chinese medicine composition of the present invention, Radix Angelicae Sinensis: sweet in the mouth, property are pungent, tepor; Return liver, the heart, spleen channel; Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation; Cure mainly that all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea, lump in the abdomen knot are poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, weight, ulcer sores, injury from falling down after bloody dysentery.
In Chinese medicine composition of the present invention, the Rhizoma Atractylodis Macrocephalae: bitter in the mouth, property are sweet, tepor; Return spleen, stomach warp; There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect; Cure mainly insufficiency of the spleen lack of appetite, abdominal distention had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
In Chinese medicine composition of the present invention, the Radix Astragali: sweet in the mouth, warm in nature; Return lung, spleen, liver, kidney channel; There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation; Cure mainly the deficiency of vital energy weak, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst.
In Chinese medicine composition of the present invention, the Rhizoma Pinelliae: acrid in the mouth, warm in nature; Return spleen, stomach warp; There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, effect of dissolving lump and resolving mass; Externally used detumescence pain relieving; Cure mainly the card of heat-phlegm, vomiting, wind-phlegm.
In Chinese medicine composition of the present invention, Fructus Aurantii Immaturus: bitter in the mouth, property be pungent, be slightly cold; Return spleen, stomach, liver, heart channel; There is circulation of qi promoting to disappear painful abdominal mass, effect that removing food stagnancy reduces phlegm; Cure mainly in stagnating and stop, feeling of fullness distending pain, constipation, heavy after dysentery, blocked-up chest, gastroptosis, uterine prolapse, proctoptosis.
In Chinese medicine composition of the present invention, Cortex Magnoliae Officinalis: bitter in the mouth, property is pungent, tepor; Return spleen, stomach, large intestine channel; Have circulation of qi promoting removing food stagnancy, dampness is removed full, effect of lowering the adverse QI to relieve asthma; Cure mainly stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, and expectorant stops up QI rising in reverse order, and fullness in the chest is breathed with cough.
In Chinese medicine composition of the present invention, Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, bitter in the mouth; Return spleen, stomach, lung meridian; There is regulating qi-flowing for strengthening spleen, in tune, dampness, the effect of reducing phlegm; Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach, the abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool, phlegm-damp stops up the cough and asthma of lung; For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
In Chinese medicine composition of the present invention, Folium Sennae: property is sweet, bitter in the mouth, be slightly cold, slightly poisonous; Return large intestine channel; There is the row that purges heat stagnant, relieving constipation, effect of diuretic; Cure mainly accumulation of heat to stagnate, constipation is suffered from abdominal pain, edema distension.
As the preferred embodiment of one, described Chinese medicine composition also comprises the herbal raw material of following weight portion: raw Semen sojae atricolor 10-15 part, Fructus Lycii 30-40 part, Radix Ophiopogonis 30-40 part, Plumula Nelumbinis 30-40 part, Fructus Momordicae 20-30 part, Fructus Sophorae 10-15 part, Fructus Schisandrae Chinensis 20-30 part, Radix Polygoni Multiflori 20-30 part.
The present invention can also continue to add the Chinese herbal medicine such as raw Semen sojae atricolor, Fructus Lycii, Radix Ophiopogonis, Plumula Nelumbinis, Fructus Momordicae, the Fructus Sophorae, Fructus Schisandrae Chinensis and Radix Polygoni Multiflori, the present invention adopts pure natural plant to obtain, green non-pollution, also have the kidney invigorating and essence nourishing concurrently, YIN nourishing surged and moisturized effect of spleen invigorating, strengthen gastrointestinal peristalsis, adjustment gastrointestinal motility function, correct the gastrointestinal motility dysfunction of pathological state, comprehensive microcirculation improving human body, thus thoroughly radical cure constipation and complication thereof, the empty interior-heat simultaneously of body being particularly suitable for treating old people stagnates excess syndrome.
In Chinese medicine composition of the present invention, raw Semen sojae atricolor: sweet in the mouth, cold in nature; There is the kidney invigorating tonifying YIN, invigorating spleen to remove dampness, effect except thermal detoxification; Cure mainly cloudy losing of suffering from a deficiency of the kidney, polydipsia of quenching one's thirst, frequent micturition, the hepatic and renal YIN deficiency, have a dizzy spell, poor vision.
In Chinese medicine composition of the present invention, Fructus Lycii: sweet in the mouth, property is put down; Return liver, kidney, lung meridian; There is nourishing the liver, nourishing kidney, effect of lung moistening; Cure mainly caused by liver and kidney deficiency, have a dizzy spell, visual unclear, soreness of the waist and knees, impotence and seminal emission, cough due to consumptive disease, taking fluids profusely of quenching one's thirst.
In Chinese medicine composition of the present invention, Radix Ophiopogonis: property is sweet, bitter in the mouth is slightly cold; Enter lung, stomach, heart channel; For the tuber of liliaceous plant dwarf lilyturf, there is YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire; Cure mainly dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
In Chinese medicine composition of the present invention, Plumula Nelumbinis: bitter in the mouth, cold in nature; GUIXIN, lung, kidney three warp; Have and clear away heart-fire, reduce phlegm and internal heat, hemostasis, effect of arresting seminal emission; Cure mainly vexed, thirsty, spit blood, seminal emission, gentle QI of five ZANG-organs.
In Chinese medicine composition of the present invention, Fructus Momordicae: cool in nature, sweet in the mouth; Return lung, large intestine channel; There are clearing heat and moistening lung, cough-relieving, sore-throat relieving, effect of laxation relieving constipation; Cure mainly lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.
In Chinese medicine composition of the present invention, the Fructus Sophorae: bitter in the mouth, cold in nature; Return liver, large intestine channel; There is clearing away heat-fire, effect of cooling blood for hemostasis; Cure mainly intestinal heat to have blood in stool, hemorrhoid swell hemorrhage, and liver-heat is had a headache, dizzy conjunctival congestion.
In Chinese medicine composition of the present invention, Fructus Schisandrae Chinensis: property is sweet, sour in the mouth, tepor; Enter lung, kidney, heart channel; Have supplementing QI for promoting the production of body fluid, the kidney invigorating is nourished heart, and restrains astringent or styptic treatment for spontaneous sweating effect; Cure mainly deficiency of vital energy Tianjin wound, the tired hyperhidrosis of body, cardiopalmus of losing heart; Breathing with cough caused by insufficiency of lung-QI or deficiency of both the lung and kidney, or breath with cough with the passing of time, lung qi consumption wound; Insufficiency of heart-YIN, severe palpitation, insomnia forgetfulness; Instability of kidney QI, seminal emission, frequent micturition, or asthenia of both the spleen and kidney, incessant chronic diarrhea.
In Chinese medicine composition of the present invention, Radix Polygoni Multiflori: bitter in the mouth, property are sweet, tepor; Return liver, kidney channel; There is effect of invigorating the liver and kidney, benefiting essence-blood, bone and muscle strengthening, black hair, juice of calming the nerves, stop; Cure mainly blood deficiency, Light-headedness, fatigue and asthenia, sallow; Liver and kidney blood and essence asthenia, vertigo and tinnitus, waist urushic acid is soft, early whitening of beard and hair; Hyperlipidemia.
As the preferred embodiment of one, the dosage form of described Chinese medicine composition is slow releasing preparation.Slow releasing preparation can delay and Drug controlled release, thus this Chinese medicine composition is discharged just in intestinal, thus makes drug effect until focus part.
As the preferred embodiment of one, described slow releasing preparation is slow releasing pill, slow releasing capsule, slow releasing tablet and sustained-release granular formulation.Slow releasing preparation can make various ways, facilitates taking of patient; Its mild in medicine property and, taste is moderate, easily take without pained taste, gentleness.
As the preferred embodiment of one, the adjuvant of described slow releasing pill is ethyl cellulose and acrylic resin.The adjuvant source of this slow releasing pill is easily, cheap, conveniently obtains, and makes it prepare simply, adjuvant interpolation kind and quantity few, do not affect the active constituent content of medicament, be easy to realize industrialization.
As the preferred embodiment of one, the diameter of described slow releasing pill is 4-6mm, and every ball weight is 0.5g.Slow releasing pill is of moderate size, taking convenience, cheap, greatly reduces economy and the psychological burden of patient.
Usage and consumption: traditional Chinese medicine slow-releasing pill of the present invention, every twice-daily, each 4 balls, within 5 days, be a course for the treatment of, 1-3 the course for the treatment of can cure.
Beneficial effect of the present invention: in Chinese medicine composition of the present invention, various Chinese herbal medicine compatibility science, drug effect complement each other, bring out the best in each other, and Radix Et Rhizoma Rhei purging heat to relax the bowels, cleanses the intestines and stomach, are monarch drug; Radix Codonopsis, Radix Astragali QI invigorating, in case rush down therapeutic method to keep the adverse QI flowing downwards holder, are ministerial drug; Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus promoting QI to circulate and dispersing the agglomeration of the pathogens, relieving distension and oppression, and help Radix Et Rhizoma Rhei to push away to swing stagnant with the excretion accelerating accumulation of heat, altogether for assistant makes; The raw Semen sojae atricolor of all right compatibility, Fructus Lycii, Radix Ophiopogonis, Plumula Nelumbinis, Fructus Momordicae, the Fructus Sophorae, Fructus Schisandrae Chinensis and Radix Polygoni Multiflori, while possessing clearing away heat and moistening the bowels, dissolving lump and resolving mass and benefiting QI and nourishing blood effect, also have the kidney invigorating and essence nourishing concurrently, YIN nourishing surged and moisturized effect of spleen invigorating, enhance gastrointestinal peristalsis, have adjusted gastrointestinal motility function, comprehensive microcirculation improving human body, pass through slow releasing preparation, drug effect is gone directly focus depths, reach the object for the treatment of both the principal and secondary aspects of a disease, thus thoroughly radical cure constipation and complication thereof, the empty interior-heat simultaneously of body being particularly suitable for treating old people stagnates excess syndrome.
Detailed description of the invention
Be clearly and completely described technical scheme of the present invention below in conjunction with specific embodiments of the invention, obviously, described embodiment is only a part of embodiment of the present invention, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
A kind of Chinese medicine composition for the treatment of constipation of the present invention, described Chinese medicine composition comprises the herbal raw material of following weight portion: Radix Et Rhizoma Rhei 30-40 part, Radix Codonopsis 45-60 part, Radix Angelicae Sinensis 30-40 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Astragali 15-20 part, Rhizoma Pinelliae 15-20 part, Fructus Aurantii Immaturus 30-40 part, Cortex Magnoliae Officinalis 30-40 part, Pericarpium Citri Reticulatae 15-20 part, Folium Sennae 30-40 part.
Further, described Chinese medicine composition also comprises the herbal raw material of following weight portion: raw Semen sojae atricolor 10-15 part, Fructus Lycii 30-40 part, Radix Ophiopogonis 30-40 part, Plumula Nelumbinis 30-40 part, Fructus Momordicae 20-30 part, Fructus Sophorae 10-15 part, Fructus Schisandrae Chinensis 20-30 part, Radix Polygoni Multiflori 20-30 part.
Preferably, the dosage form of described Chinese medicine composition is slow releasing preparation.
Further, described slow releasing preparation is slow releasing pill, slow releasing capsule, slow releasing tablet and sustained-release granular formulation.
Again further, the adjuvant of described slow releasing pill is ethyl cellulose and acrylic resin.
Further, the diameter of described slow releasing pill is 4-6mm, and every ball weight is 0.5g.
embodiment one
Treat a Chinese medicine composition for constipation, this Chinese medicine composition comprises the herbal raw material of following weight portion: Radix Et Rhizoma Rhei 30g, Radix Codonopsis 45g, Radix Angelicae Sinensis 30g, Rhizoma Atractylodis Macrocephalae 15g, Radix Astragali 15g, Rhizoma Pinelliae 15g, Fructus Aurantii Immaturus 30g, Cortex Magnoliae Officinalis 30g, Pericarpium Citri Reticulatae 15g, Folium Sennae 30g.
Get above-mentioned Chinese medicine composition, grinding, immersion, decoction, concentrate drying, and add ethyl cellulose and acrylic resin adjuvant, thus make slow releasing preparation; This slow releasing preparation can be slow releasing pill, certainly, can also make slow releasing capsule, slow releasing tablet or sustained-release granular formulation; The diameter of this slow releasing pill is 4-6mm, and every ball weight is 0.5g; Every twice-daily, each 4 balls, within 5 days, be a course for the treatment of, 1-3 the course for the treatment of can cure.
embodiment two
Treat a Chinese medicine composition for constipation, this Chinese medicine composition comprises the herbal raw material of following weight portion: Radix Et Rhizoma Rhei 40g, Radix Codonopsis 60g, Radix Angelicae Sinensis 40g, Rhizoma Atractylodis Macrocephalae 20g, Radix Astragali 20g, Rhizoma Pinelliae 20g, Fructus Aurantii Immaturus 40g, Cortex Magnoliae Officinalis 40g, Pericarpium Citri Reticulatae 20g, Folium Sennae 40g.
Get above-mentioned Chinese medicine composition, grinding, immersion, decoction, concentrate drying, and add ethyl cellulose and acrylic resin adjuvant, thus make sustained release granule; This sustained-release granular formulation, often wraps 1g, every twice-daily, and each 2 bags, within 5 days, be a course for the treatment of, 1-3 the course for the treatment of can cure.
embodiment three
Treat a Chinese medicine composition for constipation, this Chinese medicine composition comprises the herbal raw material of following weight portion: Radix Et Rhizoma Rhei 35g, Radix Codonopsis 50g, Radix Angelicae Sinensis 35g, Rhizoma Atractylodis Macrocephalae 18g, Radix Astragali 18g, Rhizoma Pinelliae 18g, Fructus Aurantii Immaturus 35g, Cortex Magnoliae Officinalis 35g, Pericarpium Citri Reticulatae 18g, Folium Sennae 35g.
Get above-mentioned Chinese medicine composition, grinding, screening, mixing, and add ethyl cellulose and acrylic resin adjuvant, thus make slow releasing pill; The diameter of this slow releasing pill is 8-10mm, and every ball weight is 1g; Every twice-daily, each 4 balls, within 5 days, be a course for the treatment of, 1-3 the course for the treatment of can cure.
embodiment four
Treat a Chinese medicine composition for constipation, this Chinese medicine composition comprises the herbal raw material of following weight portion: Radix Et Rhizoma Rhei 30g, Radix Codonopsis 45g, Radix Angelicae Sinensis 30g, Rhizoma Atractylodis Macrocephalae 15g, Radix Astragali 15g, Rhizoma Pinelliae 15g, Fructus Aurantii Immaturus 30g, Cortex Magnoliae Officinalis 30g, Pericarpium Citri Reticulatae 15g, Folium Sennae 30g, raw Semen sojae atricolor 10g, Fructus Lycii 30g, Radix Ophiopogonis 30g, Plumula Nelumbinis 30g, Fructus Momordicae 20g, Fructus Sophorae 10g, Fructus Schisandrae Chinensis 20g, Radix Polygoni Multiflori 20g.
Get above-mentioned Chinese medicine composition, grinding, immersion, decoction, concentrate drying, and add ethyl cellulose and acrylic resin adjuvant, thus make sustained release capsule; The heavy 1g of this slow releasing capsule every, every twice-daily, each 2, within 5 days, be a course for the treatment of, 1-3 the course for the treatment of can cure.
embodiment five
Treat a Chinese medicine composition for constipation, this Chinese medicine composition comprises the herbal raw material of following weight portion: Radix Et Rhizoma Rhei 40g, Radix Codonopsis 60g, Radix Angelicae Sinensis 40g, Rhizoma Atractylodis Macrocephalae 20g, Radix Astragali 20g, Rhizoma Pinelliae 20g, Fructus Aurantii Immaturus 40g, Cortex Magnoliae Officinalis 40g, Pericarpium Citri Reticulatae 20g, Folium Sennae 40g, raw Semen sojae atricolor 15g, Fructus Lycii 40g, Radix Ophiopogonis 40g, Plumula Nelumbinis 40g, Fructus Momordicae 30g, Fructus Sophorae 15g, Fructus Schisandrae Chinensis 30g, Radix Polygoni Multiflori 30g.
Get above-mentioned Chinese medicine composition, grinding, immersion, decoction, concentrate drying, and add ethyl cellulose and acrylic resin adjuvant, thus make sustained release tablet; The heavy 1g of the every sheet of this slow releasing tablet, every twice-daily, each 2, within 5 days, be a course for the treatment of, 1-3 the course for the treatment of can cure.
animal toxicity test
By the Chinese medicine composition of the embodiment of the present invention one to embodiment five, carry out repeatedly animal toxicity test respectively; During each test, get mice 30, body weight 18-24g, be divided into two groups at random, often organize 15, wherein one group is overdose test group, and another group is normal amount test group, overdose test group consumption is 8g/kg, normal amount test group consumption is 4g/Kg, and administering mode is administration by gavage administration, administration every day 3 times, successive administration 7 days, observes administration reaction every day; Test of many times all result shows, two groups of mices are showed no death, and its feed, breathing, activity, heart beating, defecation, chaeta etc. are showed no exception; Cut open inspection, naked eyes examine main inside internal organs, no abnormality seen; Therefore, this Chinese medicine composition is without bad toxic and side effects.
animal pharmacodynamics test
Chinese medicine composition of the present invention impact of interior real stagnation of pathogenic heat type animal models of constipation on body void
1, Chinese medicine composition of the present invention is tested model mice 24h defecation situation
Get healthy SPF level Kunming mouse 70, male and female half and half, body weight 18-24g, utilize dry foodstuff to prohibit water non-fasting 72h, cause body empty and interior real stagnation of pathogenic heat type mice with constipation model.
Model mice is divided into 7 groups at random, often organize 10, be respectively blank group, commercially available certain treatment the medicine pill administration group of constipation, Chinese medicine composition administration group of the embodiment of the present invention one to embodiment five, administering mode adopts gastric infusion, the normal saline of blank group gavage equivalent; After administration, each mice is put into alone one and raise box, the clean filter paper of place mat at the bottom of box; Observe the character just of each Oletum Ratti norvegici in 24h and feces volume, calculate the percentage ratio that loose stool accounts for full excrement number; And be placed on weight in wet base electronic balance weighing up total feces, then it is wrapped with filter paper, put into electric drying oven with forced convection, 30min is dried through 80 DEG C, put into the exsiccator filling discolour silica gel after taking-up immediately, take out when its temperature is identical with room temperature, claim its dry weight, then from weight in wet base, dry weight is deducted, obtain the weight of moisture, calculate the percentage by weight of the shared full feces of moisture, result of the test means standard deviation represents, with the significance of its difference of t inspection, the results are shown in Table 1.
2, Chinese medicine composition of the present invention is tested rat model intestinal impetus
Get healthy SPF level Wistar rat 70, body weight 180-240g, male and female half and half, utilize dry foodstuff to prohibit water non-fasting 72h, cause body empty and interior real stagnation of pathogenic heat type constipation rat model.Rat model is divided into 7 groups at random, often organize 10, be respectively blank group, commercially available certain treatment the medicine pill administration group of constipation, Chinese medicine composition administration group of the embodiment of the present invention one to embodiment five, administering mode adopts gastric infusion, the normal saline of blank group gavage equivalent; After administration 30min, seven treated animals only all gavage the phenol red liquid 5mL/ of 5%.After 90min, rat is put to death, cuts open the belly immediately, by digestive tract by cardia until anus intactly extracts, do not add traction and be laid in laboratory table, with phenol red forward position this medicine of position judgment extremely on the impact of rat stomach bowel movement, result of the test means standard deviation represents, uses X
2the significance of its difference of inspection, the results are shown in Table 2.
3, experimental result
Table 1 Chinese medicine composition of the present invention is on the impact of mice 24h defecation situation
Remarks: compared with blank group, *---p<0.05, * *---P<0.01.
As can be seen from Table 1, compared with blank group, moisture in the embodiment of the present invention one to the percent that the Chinese medicine composition of embodiment five and the medicine pill of certain treatment constipation commercially available all significantly can increase the feces volume of model mice, loose stool number, loose stool account for total feces and stool, through statistical procedures significance.Compared with treating the medicine pill of constipation with commercially available certain, the embodiment of the present invention one significantly can increase moisture in the feces volume of model mice, loose stool number and stool to the Chinese medicine composition of embodiment five; Simultaneously, which reduce the percent that loose stool accounts for total feces, namely the embodiment of the present invention one reaches the object of relieving constipation to the Chinese medicine composition of embodiment five by lubrication intestinal, the anus of model mice is not polluted, the medicine pill breaching certain commercially available treatment constipation, based on the total TBL alkaloid let out, significantly improves the bowel movement function of Constipation Model mice, adds defecation frequency and defecation weight, shorten defecation time, soften feces.
Table 2 Chinese medicine composition of the present invention is on the impact of intestine in rats impetus
Remarks: compared with blank group, *---p<0.05, * *---P<0.01.
As can be seen from Table 2, compared with blank group, the embodiment of the present invention one all significantly can increase the phenol red speed by ileocecus in rat model, through statistical procedures significance to the Chinese medicine composition of embodiment five and the medicine pill of certain commercially available treatment constipation.Compared with treating the medicine pill of constipation with commercially available certain, the embodiment of the present invention one has more advantage to the Chinese medicine composition of embodiment five.This illustrates that the medicine pill of Chinese medicine composition of the present invention certain treatment constipation more commercially available has the effect significantly promoting the secretion of intestinal moisture, the myenteron shrinkage amplitude of rat model and frequency can be made obviously to increase, add the intestinal propulsion functions of rat model, have adjusted the gastrointestinal motility function of rat model.
clinical observation is tested
Diagnostic criteria
With reference to " Chinese medical disease Standardization of diagnosis and curative effect ".
Defecation time extends, and defecation is less than 3 times weekly, feces dry, hard; Severe one difficulty in defecation, dry as chestnut, little abdominal distention can be accompanied anxious, and god is tired weak, and stomach poor appetite moves back, and belongs to body void and the stagnant knot of interior-heat is demonstrate,proved; And get rid of intestinal organic disease.
Patient data
Choose constipation patient 600 example meeting above-mentioned standard, wherein, man 300 example, female 300 example, minimum 10 years old of age, oldest 70 years old, 45.4 years old mean age, the course of disease arrived Two decades years in one month, six groups are divided into according to the method for M-F, ratio of age and course of disease balanced proportion, a matched group, five treatment groups, do not have diversity statistically between these two groups of patients.Before accepting this treatment, all once adopted the Therapeutic Method such as other Western medicine, Chinese medicine, but effect is not remarkable, easily recurs, can not dig up the roots.
Therapeutic scheme
Matched group: patient takes the medicine pill of certain commercially available treatment constipation, every day 2 times, each 30 balls, amounting to 8g, 10 days is a course for the treatment of, treats 3 courses for the treatment of continuously;
Treatment group: patient takes the Chinese medicine composition of the embodiment of the present invention one to embodiment five, every day 2 times, each 2g 5 days is a course for the treatment of, treats 3 courses for the treatment of continuously;
Follow up a case by regular visits to every day once, treat complete after, continue to follow up a case by regular visits to 1 year, before treatment, further consultation and fill in case report form when following up a case by regular visits to;
All experimenters all must not merge the medicine using other treatment constipation any and the medicine that may affect clinical efficacy and untoward reaction evaluation at duration of test.
Efficacy assessment standard
With reference to " Chinese medical disease Standardization of diagnosis and curative effect ".
Recovery from illness: stool deliquescing, every day defecation 1 time, other symptom all disappears;
Effective: constipation is clearly better, just matter is normal, time interval 1-2 days, and other symptom 2/3 disappears;
Effective: just matter is dry and hard makes moderate progress, the stool intermittent time shortened 1-2 days more originally, and other symptom has certain improvement;
Invalid: constipation and other symptom are all without improvement.
Recovery from illness adds effective adding and effectively adds up to total effective rate.
Clinical observation result
Through over nearly 2 years clinical experiment observe, the most at last observed result gather arrange as shown in table 3.
Table 3 clinical treatment outcome summary sheet
As can be seen from Table 3, five kinds of Chinese medicine compositions of the present invention all have good curative effect to the treatment of constipation, and clearly, cure rate obviously raises advantage, reaches 92%, does not occur Ineffective Cases, and total effective rate is 100%; Dose is few, mild in medicine property and, taste is moderate, without pained taste, taking convenience, without drug dependence, instant effect, significantly reduces the misery of patient; Stable curative effect, does not recur, and has no side effect, treating both the principal and secondary aspects of a disease.
Model case
Case 1: Lee, female, 40 years old, foreign enterprise worker, patient's readme, over nearly 5 years, always 4-5 talent row once defecates, constipation, and defecation is very painstaking, general sensation is uncomfortable, abdominal distention stomachache, bitter taste xerostomia, has a dizzy spell, soreness of the waist and knees, is body void and the stagnant junction type constipation of interior-heat through hospital diagnosis.Once took the medicine pill of commercially available treatment constipation, stool increases, but still has abdominal distention to suffer from abdominal pain and bitter taste xerostomia, and this medication journey is long, takes effect slow, can not dig up the roots; After taking Chinese medicine composition of the present invention, take 2 days, defecation frequency increases, and a course for the treatment of, defecation is clearly better; Continue to take a course for the treatment of, defecate unimpeded, transference cure; Follow up a case by regular visits to 1 year, keep defecate every day 1-2 time, have no recurrence.
Case 2: section, man, 56 years old, builder, patient's readme, closely during the last ten years, always 7-8 talent draws and once defecates, and stool is in spherical, very painstaking when widening just, sometimes can not draw any more, use hands button, general sensation is uncomfortable, dizzy xerostomia, complexion is pale simple and unadorned, pale tongue with white fur, deep-thready pulse, is the empty and stagnant junction type constipation of interior-heat of body through hospital diagnosis.Once took TONGBIAN LING, also once took the Chinese medicine decoction of some treatment constipation, it takes inconvenience before, and bitter in the mouth is difficult to swallow, and, DeGrain, bad during fashion, bring heavy psychological burden to patient; Take Chinese medicine composition of the present invention, after the course for the treatment of, stool increases; Continue to take a course for the treatment of, defecation is clearly better, and symptom alleviates; Continue to take a course for the treatment of, defecate unimpeded, transference cure; Follow up a case by regular visits to 1 year, keep defecate every day 1 time, constipation symptom has no recurrence.
Case 3: Ma, man, 23 years old, student enrollment, patient's readme, closely over the past half year, in sight owing to graduating, study and employment pressure large, fatigue and depression, occur constipation symptom, about have 5 days and do not defecate, abdominal distention is suffered from abdominal pain, bitter taste xerostomia, red tongue with yellow fur, oliguria with reddish urine is the empty and stagnant junction type constipation of interior-heat of body through hospital diagnosis.Once took cathartic, phenolphthalein sugar medicine carried out relieving constipation, suffered from diarrhoea again during relieving constipation for more than 10 times, drug withdrawal stool and obstructed; Take Chinese medicine composition of the present invention, after taking 2 days, defecation frequency increases, and defecation is clearly better; After the course for the treatment of, defecate unimpeded, transference cure; Follow up a case by regular visits to 1 year, keep defecate every day 1-2 time, have no recurrence.
The invention has the beneficial effects as follows: in Chinese medicine composition of the present invention, various Chinese herbal medicine compatibility science, drug effect complement each other, bring out the best in each other, and Radix Et Rhizoma Rhei purging heat to relax the bowels, cleanses the intestines and stomach, are monarch drug; Radix Codonopsis, Radix Astragali QI invigorating, in case rush down therapeutic method to keep the adverse QI flowing downwards holder, are ministerial drug; Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus promoting QI to circulate and dispersing the agglomeration of the pathogens, relieving distension and oppression, and help Radix Et Rhizoma Rhei to push away to swing stagnant with the excretion accelerating accumulation of heat, altogether for assistant makes; The raw Semen sojae atricolor of all right compatibility, Fructus Lycii, Radix Ophiopogonis, Plumula Nelumbinis, Fructus Momordicae, the Fructus Sophorae, Fructus Schisandrae Chinensis and Radix Polygoni Multiflori, while possessing clearing away heat and moistening the bowels, dissolving lump and resolving mass and benefiting QI and nourishing blood effect, also have the kidney invigorating and essence nourishing concurrently, YIN nourishing surged and moisturized effect of spleen invigorating, enhance gastrointestinal peristalsis, have adjusted gastrointestinal motility function, comprehensive microcirculation improving human body, pass through slow releasing preparation, drug effect is gone directly focus depths, reach the object for the treatment of both the principal and secondary aspects of a disease, thus thoroughly radical cure constipation and complication thereof, the empty interior-heat simultaneously of body being particularly suitable for treating old people stagnates excess syndrome.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (6)
1. treat a Chinese medicine composition for constipation, it is characterized in that: described Chinese medicine composition comprises the herbal raw material of following weight portion:
Radix Et Rhizoma Rhei 30-40 part, Radix Codonopsis 45-60 part, Radix Angelicae Sinensis 30-40 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Astragali 15-20 part, Rhizoma Pinelliae 15-20 part, Fructus Aurantii Immaturus 30-40 part, Cortex Magnoliae Officinalis 30-40 part, Pericarpium Citri Reticulatae 15-20 part, Folium Sennae 30-40 part.
2. the Chinese medicine composition for the treatment of constipation according to claim 1, is characterized in that: described Chinese medicine composition also comprises the herbal raw material of following weight portion:
Raw Semen sojae atricolor 10-15 part, Fructus Lycii 30-40 part, Radix Ophiopogonis 30-40 part, Plumula Nelumbinis 30-40 part, Fructus Momordicae 20-30 part, Fructus Sophorae 10-15 part, Fructus Schisandrae Chinensis 20-30 part, Radix Polygoni Multiflori 20-30 part.
3. the Chinese medicine composition for the treatment of constipation according to claim 1 and 2, is characterized in that:
The dosage form of described Chinese medicine composition is slow releasing preparation.
4. the Chinese medicine composition for the treatment of constipation according to claim 3, is characterized in that:
Described slow releasing preparation is slow releasing pill, slow releasing capsule, slow releasing tablet and sustained-release granular formulation.
5. the Chinese medicine composition for the treatment of constipation according to claim 4, is characterized in that:
The adjuvant of described slow releasing pill is ethyl cellulose and acrylic resin.
6. the Chinese medicine composition for the treatment of constipation according to claim 5, is characterized in that:
The diameter of described slow releasing pill is 4-6mm, and every ball weight is 0.5g.
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| CN116370559A (en) * | 2023-04-07 | 2023-07-04 | 信阳师范学院 | Application of pinellia ternate in treating constipation |
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Application publication date: 20151014 |