CN104968686B - 趋化素-细胞素融合蛋白和其应用 - Google Patents

趋化素-细胞素融合蛋白和其应用 Download PDF

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CN104968686B
CN104968686B CN201280077622.3A CN201280077622A CN104968686B CN 104968686 B CN104968686 B CN 104968686B CN 201280077622 A CN201280077622 A CN 201280077622A CN 104968686 B CN104968686 B CN 104968686B
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CN104968686A (zh
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邱绣河
周宽基
沈瑞鸿
范怡馨
林佩桦
吴佩珊
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Xue Fusheng
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5421—IL-8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • A61K2039/55533—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201280077622.3A 2012-12-05 2012-12-05 趋化素-细胞素融合蛋白和其应用 Active CN104968686B (zh)

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PCT/CN2012/001629 WO2014085947A1 (zh) 2012-12-05 2012-12-05 趋化素-细胞素融合蛋白和其应用

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CN104968686A CN104968686A (zh) 2015-10-07
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US (4) US20150307577A1 (enExample)
EP (1) EP2930189B1 (enExample)
JP (1) JP6174710B2 (enExample)
CN (1) CN104968686B (enExample)
AU (1) AU2012396113B2 (enExample)
CA (1) CA2893981C (enExample)
WO (1) WO2014085947A1 (enExample)

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BR112019018915A2 (pt) 2017-03-15 2020-04-14 Pandion Therapeutics Inc imunotolerância direcionada
AU2018273914A1 (en) 2017-05-24 2019-11-14 Pandion Operations, Inc. Targeted immunotolerance
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
AU2020279240A1 (en) 2019-05-20 2021-12-23 Pandion Operations, Inc. MAdCAM targeted immunotolerance
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
KR20240024781A (ko) * 2021-04-19 2024-02-26 워킹 피쉬 테라퓨틱스 인코포레이티드 세포 요법에 사용하기 위한 b 세포 확장의 방법

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN1382158A (zh) * 1999-08-09 2002-11-27 利思进药品公司 多细胞因子－抗体复合物

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CA2322687A1 (en) * 1999-10-29 2001-04-29 Regents Of The University Of California Compositions containing c-terminal polypeptides of angiogenic chemokines and methods of use
WO2001040311A1 (fr) * 1999-11-30 2001-06-07 Shionogi & Co., Ltd. Proteine fusionnee de chimiokine slc-il2
US20050053579A1 (en) * 2001-10-23 2005-03-10 Jacques Galipeau Novel synthetic chimeric fusion transgene with immuno-therapeutic uses
US20050287118A1 (en) * 2003-11-26 2005-12-29 Epitomics, Inc. Bacterial plasmid with immunological adjuvant function and uses thereof
CN101445560A (zh) * 2008-12-31 2009-06-03 河南省生物工程技术研究中心 一种畜禽用融合蛋白的制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1382158A (zh) * 1999-08-09 2002-11-27 利思进药品公司 多细胞因子－抗体复合物

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
IL-12基因联合CD40L基因治疗小鼠黑色素瘤的实验研究;张建华;《中国免疫学杂志》;20071231;第23卷;摘要 *
MIP-2γ/GM-CSF融合蛋白的构建、表达及其双重生物学功能的初步研究;张意等;《中国肿瘤生物治疗杂志》;20040430;第11卷(第2期);第133-137页 *
mSDF-1γ/GM-CS融合蛋白的制备及其对辐射小鼠造血损伤恢复的促进;徐斌等;《中国肿瘤生物治疗杂志》;20091231;第16卷(第1期);第24-28页 *
SDF-1γ/ rhGM-CSF 融合蛋白的制备及其趋化作用;居小萍等;《中国肿瘤生物治疗杂志》;20110830;第18卷(第4期);第2.4节、图4 *
融合基因CCL21-CD40L对结肠癌主动免疫的诱导;宫婷;《中国优秀硕士学位论文全文数据库 医药卫生科技辑》;20091215;第3.7节、图20、图21，第46页最后一段 *

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US10336801B2 (en) 2019-07-02
US20150307577A1 (en) 2015-10-29
AU2012396113A1 (en) 2015-07-02
WO2014085947A1 (zh) 2014-06-12
US20190270788A1 (en) 2019-09-05
EP2930189A4 (en) 2016-06-08
CA2893981A1 (en) 2014-06-12
US20230265150A1 (en) 2023-08-24
EP2930189A1 (en) 2015-10-14
AU2012396113B2 (en) 2017-03-30
JP6174710B2 (ja) 2017-08-02
JP2016503434A (ja) 2016-02-04
CA2893981C (en) 2021-11-16
US20170327554A1 (en) 2017-11-16
EP2930189B1 (en) 2020-04-29
CN104968686A (zh) 2015-10-07

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