AU2012396113B2 - Chemokine-cytokine fusion protein and application thereof - Google Patents

Chemokine-cytokine fusion protein and application thereof Download PDF

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Publication number
AU2012396113B2
AU2012396113B2 AU2012396113A AU2012396113A AU2012396113B2 AU 2012396113 B2 AU2012396113 B2 AU 2012396113B2 AU 2012396113 A AU2012396113 A AU 2012396113A AU 2012396113 A AU2012396113 A AU 2012396113A AU 2012396113 B2 AU2012396113 B2 AU 2012396113B2
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AU
Australia
Prior art keywords
chemokine
polypeptide
fusion protein
cytokine
cells
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AU2012396113A
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English (en)
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AU2012396113A1 (en
Inventor
Shiow-Her Chiou
Kuan-Chih Chow
Yi-Hsin Fan
Pei-hua LIN
Jui-Hung Shien
Pei-Shan Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Chung Hsing University
Original Assignee
Univ Nat Chung Hsing
National Chung Hsing University
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Publication of AU2012396113A1 publication Critical patent/AU2012396113A1/en
Assigned to NATIONAL CHUNG HSING UNIVERSITY reassignment NATIONAL CHUNG HSING UNIVERSITY Request for Assignment Assignors: CHIOU, SHIOW-HER
Application granted granted Critical
Publication of AU2012396113B2 publication Critical patent/AU2012396113B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5421—IL-8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • A61K2039/55533—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2012396113A 2012-12-05 2012-12-05 Chemokine-cytokine fusion protein and application thereof Active AU2012396113B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2012/001629 WO2014085947A1 (zh) 2012-12-05 2012-12-05 趋化素-细胞素融合蛋白和其应用

Publications (2)

Publication Number Publication Date
AU2012396113A1 AU2012396113A1 (en) 2015-07-02
AU2012396113B2 true AU2012396113B2 (en) 2017-03-30

Family

ID=50882722

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012396113A Active AU2012396113B2 (en) 2012-12-05 2012-12-05 Chemokine-cytokine fusion protein and application thereof

Country Status (7)

Country Link
US (4) US20150307577A1 (enExample)
EP (1) EP2930189B1 (enExample)
JP (1) JP6174710B2 (enExample)
CN (1) CN104968686B (enExample)
AU (1) AU2012396113B2 (enExample)
CA (1) CA2893981C (enExample)
WO (1) WO2014085947A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7165717B2 (ja) 2017-03-15 2022-11-04 パンディオン・オペレーションズ・インコーポレイテッド 標的免疫寛容
MX2019013517A (es) 2017-05-24 2020-08-17 Pandion Operations Inc Inmunotolerancia dirigida.
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
EP3972992A4 (en) 2019-05-20 2023-07-19 Pandion Operations, Inc. MADCAM TARGETED IMMUNOTLERANCE
WO2021168079A1 (en) 2020-02-21 2021-08-26 Pandion Operations, Inc. Tissue targeted immunotolerance with a cd39 effector
TW202309270A (zh) * 2021-04-19 2023-03-01 美商步行魚醫療公司 用於細胞療法的ｂ細胞擴增之方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001040311A1 (fr) * 1999-11-30 2001-06-07 Shionogi & Co., Ltd. Proteine fusionnee de chimiokine slc-il2

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU778611B2 (en) * 1999-08-09 2004-12-16 Merck Patent Gmbh Multiple cytokine-antibody complexes
CA2322687A1 (en) * 1999-10-29 2001-04-29 Regents Of The University Of California Compositions containing c-terminal polypeptides of angiogenic chemokines and methods of use
US20050053579A1 (en) * 2001-10-23 2005-03-10 Jacques Galipeau Novel synthetic chimeric fusion transgene with immuno-therapeutic uses
US20050287118A1 (en) * 2003-11-26 2005-12-29 Epitomics, Inc. Bacterial plasmid with immunological adjuvant function and uses thereof
CN101445560A (zh) * 2008-12-31 2009-06-03 河南省生物工程技术研究中心 一种畜禽用融合蛋白的制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001040311A1 (fr) * 1999-11-30 2001-06-07 Shionogi & Co., Ltd. Proteine fusionnee de chimiokine slc-il2

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GANG XUE ET AL: CANCER IMMUNOLOGY, IMMUNOTHERAPY, SPRINGER, BERLIN, DE, vol. 56, no. 11, 15 May 2007, pages 1831-1843. *
JU, XIAOPING ET AL.: CHIN. J. CANCER BIOTHER., vol. 18, no. 4, August 2011, pages 419-423. *

Also Published As

Publication number Publication date
CN104968686A (zh) 2015-10-07
JP6174710B2 (ja) 2017-08-02
CN104968686B (zh) 2020-02-04
CA2893981A1 (en) 2014-06-12
AU2012396113A1 (en) 2015-07-02
US20170327554A1 (en) 2017-11-16
US20150307577A1 (en) 2015-10-29
EP2930189B1 (en) 2020-04-29
WO2014085947A1 (zh) 2014-06-12
US20190270788A1 (en) 2019-09-05
US10336801B2 (en) 2019-07-02
JP2016503434A (ja) 2016-02-04
EP2930189A1 (en) 2015-10-14
CA2893981C (en) 2021-11-16
US20230265150A1 (en) 2023-08-24
EP2930189A4 (en) 2016-06-08

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PC1 Assignment before grant (sect. 113)

Owner name: NATIONAL CHUNG HSING UNIVERSITY

Free format text: FORMER APPLICANT(S): CHIOU, SHIOW-HER

FGA Letters patent sealed or granted (standard patent)