CN104940602A - Preparation method of drug for treating mild to moderate gastrorrhagia - Google Patents
Preparation method of drug for treating mild to moderate gastrorrhagia Download PDFInfo
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Abstract
The present invention discloses a preparation method of a drug for treating mild to moderate gastrorrhagia so as to solve the treatment problem of gastrorrhagia of old people. The preparation method is characterized by comprising: (1) extracting volatile oil form rubusdelavayi franch coarse powder, eucommia ulmoides coarse powder, harlequin glorybower leaf and twig coarse powder, and finger citron coarse powder for spare, wherein the drug residue is used for spare; (2) soaking oxhide gelatin and polygonatum sibiricum for 12 h with 50 deg c hot water, adding water to decoct 2 times, and merging the decocting solutions for spare, wherein each decocting time is 1 h; (3) carrying out water extraction alcohol precipitation on ecdysanthera utilis, plum blossom, haiqian, Chinese buckeye seed, cynanchum mooreanum hemsl, poncirus trifollata(l.)raf and the drug residue in the step (1) to obtain a water extraction solution; and (4) mixing the decocting solution obtained in the step (2) and the water extraction solution obtained in the step (3), carrying out pressure reducing concentration and freeze-drying, crushing, spraying the volatile oil obtained in the step (1) into the crushed material, screening with a 100-mesh sieve, and sub-packaging to obtain the finished product. According to the present invention, clinical experiment results prove that the drug of the present invention has characteristics of good senile gastrorrhagia treating effect and high safety, and is worthy of clinical application and promotion.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of preparation method being used for the treatment of light moderate gastrorrhagia medicine.
Background technology
Upper gastrointestinal hemorrhage (upper gastrointesting bleeding, UGIB), abbreviation disappears blood, and be one of common anxious, serious symptom of Digestive System Department, if do not make diagnosis rapidly, treat in time, case fatality rate can reach more than 10%.Current acute treatment methods mostly is: norepinephrine 8mg adds in 100mL normal saline, puts into refrigerator cold-storage, makes that fluid temperature is cold causes 3 DEG C ~ 4 DEG C, and point 3 ~ 4 times/d is oral or through Injection by stomach duct.This kind of method for mechanism, but promotes that surperficial coagulating effectiveness is unsatisfactory with shrinkage surface blood capillary, and therefore clinical being also reported in brine ice adds the hemostatic for external use things such as YUNNAN BAIYAO to strengthen coat of the stomach mucosa haemostatic effect.
Gerontal patient's upper gastrointestinal hemorrhage, onset is hidden, and with digestive ulcerative bleeding for the first cause of disease, a general amount of bleeding is no more than 400ml, belongs to light moderate hemorrhage more.But it is fast that old UGIB has change of illness state, merge sick and that complication is many feature, add treatment difficulty.Treatment difficulty is: 1. gerontal patient is because of the decline of physical function, the minimizing of heart pump blood volume, and whole body blood volume also reduces, and causes gastric mucosa amount of blood supply to reduce and occurs ulcerative lesions and various pathological changes, therefore as easy as rolling off a log recurrence after treatment; 2. gerontal patient's possibility long-term taking multi-medicament, with prodrug complex, as anticoagulation, glucocorticoid and NSAID (non-steroidal anti-inflammatory drug) etc. more can strengthen the probability causing mucosal lesion because gastric acid secretion increases, adds the difficulty of hemostasis simultaneously; 3. especially merge the vitals pathological changes such as the heart, brain, kidney due to normal with multiple chronic disease, it is oral that application haemostatic medicament comprises YUNNAN BAIYAO, can change originally fragile coagulation homeostasis, and hypercoagulability causes cardiovascular and cerebrovascular vessel and occurs unexpectedly.
For these reasons, there is upper gastrointestinal hemorrhage in clinical gerontal patient, and especially during gastrorrhagia, medication is limited, the complication such as easily cause aspiration pneumonitis, cardiovascular and cerebrovascular vessel surprisingly, and hemorrhage relapse rate is high.
In prior art, the haemostatic medicaments such as oral application YUNNAN BAIYAO are had to stop blooding, but because gerontal patient is often with multiple chronic disease, especially the vitals pathological changes such as the heart, brain, kidney are merged, it is oral that application haemostatic medicament comprises YUNNAN BAIYAO, can change fragile coagulation homeostasis, hypercoagulability causes cardiovascular and cerebrovascular vessel and occurs unexpectedly.And because the minimizing can not correcting heart pump blood volume causes gastric mucosa amount of blood supply to reduce occur that the gastric acid secretion that ulcerative lesions and long-term taking multi-medicament (as anticoagulation, glucocorticoid and NSAID (non-steroidal anti-inflammatory drug) etc.) bring increases, mucosal lesion, therefore relapse rate is very high.
Compared with prior art, the present invention has following characteristics:
1, prescription is to spend eucommia vine and Flos Mume for monarch: flower eucommia vine has multiple action, first local vascular external pressure can be reduced, but vasoconstriction function can not be affected, also the irritability of atrium and ventricle can not be reduced, without exciting ARR hidden danger, secondly, heavy dose of colored eucommia vine also has sedation, people can be made calm, be easy to fall asleep, but be easily waken up after sleeping, therefore stress stimulation and higher nervous activity disturbance state that acute hemorrhage of upper gastrointestinal tract brings can be alleviated, laboratory result shows, flower eucommia vine Aqueous extracts rat oral gavage (being equivalent to crude drug 1.35g/kg), blood pressure is without change, to Camphora, the convulsions that under the rat cortical that pentetrazole produces, medullary substance excitement that is excited or strychnine generation causes has facilitation.More than spend the dose comparison needed for eucommia vine pharmacological action large, when dosage is larger, easily produce the side reaction such as dizziness, vomiting, heavy dose of Flos Mume of therefore arranging in pairs or groups, can reduce adverse reaction rate, and its action pathway may be relevant with sympathetic nerve effect;
2, Folium et Ramulus Clerodendri Trichotomi contributes to flower eucommia vine reduction coat of the stomach mucosa vascular resistance, and promote blood coagulation, Semen Aesculi, Rubus delavayi Franch., Fructus Citri Sarcodactylis then contribute to alleviating local stomach discomfort sense, but because of Fructus Citri Sarcodactylis consumption gas, therefore select low dose;
3, the Cortex Eucommiae, Rhizoma Polygonati, Radix Tylophorae arenicolae, in tonify deficiency is real, improve old people's coat of the stomach mucosa thinning, lose nutritional status, significantly reduce relapse rate;
4, old people's vomiting reflex is insensitive, often can not outer row well, the stasis of blood and reducing phlegm, and therefore gets Hai Qian, Cortex Ponciri trifoliatae eleminating phlegm and freeing channels, also contributes to reducing cardiovascular and cerebrovascular complication incidence rate simultaneously;
5, gelatinum oxhide is jelly, and contributing to increases medicine Local Residence Time, and much starch in Rhizoma Polygonati and colloid have synergism equally;
6, avoid in prescription using haemostatic medicament, reduce cardiovascular and cerebrovascular vessel generation secondary crisis.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little preparation method being used for the treatment of light moderate gastrorrhagia medicine of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for the treatment of blood that old age disappears, is characterized in that being prepared from by the crude drug of following weight proportion: flower eucommia vine 10 ~ 20 parts, 3 ~ 12 parts, Flos Mume, Folium et Ramulus Clerodendri Trichotomi 3 ~ 12 parts, Semen Aesculi 12 ~ 20 parts, Rubus delavayi Franch. 12 ~ 20 parts, the Cortex Eucommiae 12 ~ 20 parts, Rhizoma Polygonati 12 ~ 20 parts, Radix Tylophorae arenicolae 12 ~ 20 parts, alizarin 12 ~ 20 parts of sea, gelatinum oxhide 3 ~ 12 parts, Fructus Citri Sarcodactylis 1 ~ 5 part, Cortex Ponciri trifoliatae 10 ~ 25 parts.
Chinese medicine of the present invention can be prepared from by following method:
(1) Rubus delavayi Franch., the Cortex Eucommiae, Folium et Ramulus Clerodendri Trichotomi, Fructus Citri Sarcodactylis coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are for subsequent use;
(2) by after gelatinum oxhide, Rhizoma Polygonati 50 DEG C of hot-water soak 12h, decoct with water 2 times, each 1 hour, collecting decoction was for subsequent use;
(3) the medicinal residues mixing in flower eucommia vine, Flos Mume, Hai Qian, Semen Aesculi, Radix Tylophorae arenicolae, Cortex Ponciri trifoliatae and step 1 is added 4 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 30 minutes, then centrifugal 5 minutes at 20 DEG C, centrifugal liquid removes ethanol, obtains Aqueous extracts;
(4) by after step 2 gained decocting liquid and the mixing of step 3 gained Aqueous extracts, concentrating under reduced pressure, the freezing universe are dry, and sprayed into by gained volatile oil in step 1 after pulverizing, 100 mesh sieves, subpackage forms.
Wherein said: flower eucommia vine is the bark of apocynaceae plant flower hide glue rattan Ecdysanthera utilisHayata etK aw.Bitter; Micro-pungent; Property is put down.Function cures mainly: dispelling wind and removing obstruction in the collateral; Promoting blood circulation and detumescence; Removing toxic substances.Main poliomyelitis sequela; Rheumatic ostalgia; Traumatic injury; Sore.
Flos Mume is the dry flower of rose department plant plum Prunus mume (Sieb.) Sieb.et Zucc..Bitter in the mouth, micro-sweet, micro-acid, cool in nature.Return liver, stomach, lung meridian.Function cures mainly: dispersing the stagnated live-QI to relieve the stagnation of QI, and appetizing is promoted the production of body fluid, and reduces phlegm.
Folium et Ramulus Clerodendri Trichotomi, is Verbena officinalis Ke Cheng paulownia platymiscium clerodendron trichotomum Clerodendron trichotomum Thunb., is used as medicine with root, stem, leaf.Taste bitter, sweet, flat.Function cures mainly: remove rheumatism.
Semen Aesculi is the dry mature seed of Hippocastanaceae plant Aesculus chinensis Bunge Aesculus chinensis Bge., Radix Aesculi Aesculus chinensis Bge.var.chekiangensis (Hu et Fang) Fang or Aesculus Aesculus wilsonii Rehd..Nature and flavor are sweet, temperature.Return liver, stomach warp.Function cures mainly: regulating the flow of QI to ease the stomach, and stomach and alleviating pain.
Rubus delavayi Franch. is the Herb of rosaceous plant SANYE Fructus Rubi corchorifolii Immaturus Rubus delavayi Franch..Sweet in the mouth; Micro-acid; Flat.GUIXIN; Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Dehumidifying dysentery relieving; Drive ascarid.
The Cortex Eucommiae is the dry bark of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv..Nature and flavor are sweet, temperature.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.
Rhizoma Polygonati is the dry rhizome of liliaceous plant P. kingianum Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor are sweet, flat.Return spleen, lung, kidney channel.Function cures mainly: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.
Radix Tylophorae arenicolae, for the spirit of asclepiadaceae plant bamboo disappears the root of Cynanchum inamoenum (Maxim.) Loes. or aerial parts.Nature and flavor are bitter; Micro-pungent; Property is put down.Return lung meridian.Function cures mainly: the kidney invigorating, spleen invigorating.
Hai Qian is the frond of Sargassaceae plant Alga Sgrgassi Enerves Sargassum enerve C.Ag., Sargassum henslowianum Sargassum henslowianum C.Ag., sargassum thunbergii Sargassum thunbergii (Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassum horneri (Turn.) C.Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.Function cures mainly: hard masses softening and resolving; Removing heat-phlegm.
Gelatinum oxhide, the glue that the skin for bovid cattle Bos taurus domesticus Gmelin is made.Sweet in the mouth; Property is put down.Return lung; Large intestine channel.Function cures mainly: nourshing Yin and drynsessmoistening prescription; Nourishing blood and hemoslasis; Promoting blood circulation and detumescence; Removing toxic substances.
Fructus Citri Sarcodactylis is the dry fruit of Rutaceae citrus plant Fructus Citri Sarcodactylis Citrus medica L.var.sarcodactylis Swingle.Nature and flavor are pungent, bitter, sour, temperature.Return liver, spleen, lung meridian.Function cures mainly: liver-smoothing, qi-regulating, and stomach and alleviating pain.Cortex Ponciri trifoliatae is Cortex Ponciri trifoliatae, is bark bits or the peel bits of rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirus tuifoliata (L.) Raf..Nature and flavor are pungent; Temperature.Return liver; Kidney channel.Function cures mainly: endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: flower eucommia vine 20g, Flos Mume 12g, Folium et Ramulus Clerodendri Trichotomi 12g, Semen Aesculi 15g, Rubus delavayi Franch. 15g, Cortex Eucommiae 15g, Rhizoma Polygonati 15g, Radix Tylophorae arenicolae 15g, extra large alizarin 15g, gelatinum oxhide 12g, Fructus Citri Sarcodactylis 2g, Cortex Ponciri trifoliatae 20g
The preparation method of embodiment 1 is: eucommia vine, the Cortex Eucommiae, Flos Mume, Hai Qian, Folium et Ramulus Clerodendri Trichotomi, Semen Aesculi, Rubus delavayi Franch., Rhizoma Polygonati, Radix Tylophorae arenicolae, Fructus Citri Sarcodactylis, gelatinum oxhide (broken), Cortex Ponciri trifoliatae mixing and water adding will be spent to decoct, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, after concentrating under reduced pressure, the freezing universe is dry, pulverized 100 mesh sieves, subpackage forms.Above-mentioned dosage is daily dose, takes at twice.
Embodiment 2, crude drug weight proportion: flower eucommia vine 10 parts, 3 parts, Flos Mume, Folium et Ramulus Clerodendri Trichotomi 3 parts, Semen Aesculi 12 parts, Rubus delavayi Franch. 12 parts, the Cortex Eucommiae 12 parts, Rhizoma Polygonati 12 parts, Radix Tylophorae arenicolae 12 parts, alizarin 12 parts of sea, gelatinum oxhide 3 parts, Fructus Citri Sarcodactylis 1 part, Cortex Ponciri trifoliatae 10 parts.
Embodiment 3, crude drug weight proportion: flower eucommia vine 20 parts, 12 parts, Flos Mume, Folium et Ramulus Clerodendri Trichotomi 12 parts, Semen Aesculi 15 parts, Rubus delavayi Franch. 15 parts, the Cortex Eucommiae 15 parts, Rhizoma Polygonati 15 parts, Radix Tylophorae arenicolae 15 parts, alizarin 15 parts of sea, gelatinum oxhide 12 parts, Fructus Citri Sarcodactylis 2 parts, Cortex Ponciri trifoliatae 20 parts
Embodiment 4, crude drug weight proportion: flower eucommia vine 20 parts, 12 parts, Flos Mume, Folium et Ramulus Clerodendri Trichotomi 12 parts, Semen Aesculi 20 parts, Rubus delavayi Franch. 20 parts, the Cortex Eucommiae 20 parts, Rhizoma Polygonati 20 parts, Radix Tylophorae arenicolae 20 parts, alizarin 20 parts of sea, gelatinum oxhide 12 parts, Fructus Citri Sarcodactylis 5 parts, Cortex Ponciri trifoliatae 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Rubus delavayi Franch., the Cortex Eucommiae, Folium et Ramulus Clerodendri Trichotomi, Fructus Citri Sarcodactylis coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are for subsequent use;
(2) by after gelatinum oxhide, Rhizoma Polygonati 50 DEG C of hot-water soak 12h, decoct with water 2 times, each 1 hour, collecting decoction was for subsequent use;
(3) the medicinal residues mixing in flower eucommia vine, Flos Mume, Hai Qian, Semen Aesculi, Radix Tylophorae arenicolae, Cortex Ponciri trifoliatae and step 1 is added 4 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 30 minutes, then centrifugal 5 minutes at 20 DEG C, centrifugal liquid removes ethanol, obtains Aqueous extracts;
(4) by after step 2 gained decocting liquid and the mixing of step 3 gained Aqueous extracts, concentrating under reduced pressure, the freezing universe are dry, and sprayed into by gained volatile oil in step 1 after pulverizing, 100 mesh sieves, subpackage forms.
Using dosage: when 1 part=1g, above-mentioned dosage is odd-numbered day dosage, takes at twice.
The efficient combination of said medicine, coordinates mutually, effectively reach treatment old upper gastrointestinal hemorrhage, the especially object of gastrorrhagia, and side effect is less, relapse rate is low.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: in March, 2011 ~ 2014 year age in the March > Patients with Upper Gastrointestinal Hemorrhage of 60 years old 121 example, wherein, man 79 example, female 42 example, 60 ~ 78 years old age, average (69.0 ± 5.4) year.When being admitted to hospital, patients goes out hematemesis in various degree, melena.
1.1.2 diagnostic criteria: with reference to " internal medicine " (the 5th edition), the equal Fecal Occult Blood Testing positive (+++) of all cases, row electronic gastroscope or x-ray barium meal examination are clarified a diagnosis as upper gastrointestinal hemorrhage.
1.1.3 exclusion standard: 1. upper gastrointestinal hemorrhage >=400ml/ time; 2. concurrent coagulation disorders disease.
1.1.4 divide into groups: be divided into matched group 40 example, embodiment 1 group of 41 example, embodiment 3 group of 40 example at random, compare in sex, age, protopathy, amount of bleeding before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 Therapeutic Method: all treat, as fasting, dilatation etc. by the conventional treatment regime of upper gastrointestinal hemorrhage acute stage after all patient admits.Matched group frozen water is taken after mixing it with water thrombin, and omeprazole 60mg intravenous drip, changes into oral after hemostasis, oral medication drug withdrawal after 2 weeks.Embodiment 1 group is with gained medicine in the embodiment of the present invention 1, and embodiment 3 groups is with gained medicine in the embodiment of the present invention 3, and using method is: get 50 ~ 100ml frozen water and take after mixing it with water, change warm water into and take after mixing it with water after hemostasis, one day twice, treats drug withdrawal after 2 weeks.
The criterion of 1.2.2 stopping blooding: 1. without hemorrhage performance, stool routine examination is without exception.2. gastric draining fluids has no hemorrhage.3. gastroscope confirms stopped bleeding.Meet above any one can judge.
1.2.3 observation index: the gross hemostasis rate of 1. treating latter 48 hours; 2. 1 month unexpected incidence rate (heart infarction, cerebral infarction, cerebral embolism) of internal congestion cardiovascular and cerebrovascular vessel; 3. relapse rate in 1 year.
1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
The 2.1 treatments gross hemostasis rate of latter 48 hours: see the following form,
* with between matched group group compare, obvious difference (P<0.05).
As can be seen from the above table, although do not use clear and definite haemostatic medicament, embodiment 1 group and embodiment 3 groups of 48h gross hemostasis rate compare with using the matched group of haemostatic medicament, no significant difference (P>0.05).Confirm that its hemostasis efficacy is equal to oral thrombin.
2.2 1 months unexpected incidence rates of internal congestion cardiovascular and cerebrovascular vessel: see the above table.As can be seen from the above table, embodiment 1 group and the unexpected incidence rate of embodiment 3 groups of 1 month internal congestion cardiovascular and cerebrovascular vessel are all starkly lower than matched group (χ
2=5.16, P<0.05; χ
2=5.00, P<0.05).Confirm that it can not destroy coagulation homeostasis.
Relapse rate in 2.3 one years: see the above table.As can be seen from the above table, in embodiment 1 group and embodiment 3 groups a year, relapse rate is all starkly lower than matched group (χ
2=6.12, P<0.05; χ
2=4.59, P<0.05).Reduce relapse rate may with its enhancing gastric mucosa nutrition, promote gastric mucosa repair relevant.
2.4 3 groups of Patient drug's related reactions incidence rates compare: obvious medicine related reactions does not all appear in three groups of patients, and before and after treatment, hematuria routine, hepatic and renal function are without significant change.
3. conclusion.
This result of study shows, take embodiments of the invention 1 group and embodiment 3 groups of 48 hours hemostasis efficacy are similar in matched group oral thrombin, and the unexpected incidence rate of 1 month internal congestion cardiovascular and cerebrovascular vessel and in 1 year relapse rate significantly lower than matched group, illustrates pharmaceutical composition prepared by the inventive method have in the old upper gastrointestinal hemorrhage for the treatment of untoward reaction comparatively gently, the higher advantage of safety.
Claims (1)
1. one kind is used for the treatment of the preparation method of light moderate gastrorrhagia medicine, it is characterized in that, be prepared from by the crude drug of following weight proportion: flower eucommia vine, the Cortex Eucommiae, Flos Mume, Hai Qian, Folium et Ramulus Clerodendri Trichotomi, Semen Aesculi, Rubus delavayi Franch., Rhizoma Polygonati, Radix Tylophorae arenicolae, Fructus Citri Sarcodactylis, gelatinum oxhide, Cortex Ponciri trifoliatae; Preparation technology is made up of following steps:
(1) Rubus delavayi Franch., the Cortex Eucommiae, Folium et Ramulus Clerodendri Trichotomi, Fructus Citri Sarcodactylis coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are for subsequent use;
(2) by after gelatinum oxhide, Rhizoma Polygonati 50 DEG C of hot-water soak 12h, decoct with water 2 times, each 1 hour, collecting decoction was for subsequent use;
(3) the medicinal residues mixing in flower eucommia vine, Flos Mume, Hai Qian, Semen Aesculi, Radix Tylophorae arenicolae, Cortex Ponciri trifoliatae and step 1 is added 4 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 30 minutes, then centrifugal 5 minutes at 20 DEG C, centrifugal liquid removes ethanol, obtains Aqueous extracts;
(4) by after step 2 gained decocting liquid and the mixing of step 3 gained Aqueous extracts, concentrating under reduced pressure, the freezing universe are dry, and sprayed into by gained volatile oil in step 1 after pulverizing, 100 mesh sieves, subpackage forms.
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2015
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|---|---|---|---|---|
| CN101081289A (en) * | 2007-04-13 | 2007-12-05 | 唐奎芳 | Medicine for relieving the flatulence and stomach-ache |
| CN101612314A (en) * | 2009-08-07 | 2009-12-30 | 冯德义 | A kind of Chinese medicine preparation for the treatment of gastric and duodenal ulcers |
| CN103263615A (en) * | 2013-06-09 | 2013-08-28 | 张玉华 | Traditional Chinese medicine preparation for treating stomach illness, enteritis and cholecystitis and preparation method thereof |
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