CN104825898A - Preparation method of drug for relieving bleeding of elder people after tooth extraction - Google Patents

Abstract

The invention discloses a preparation method of a drug for relieving bleeding of elder people after tooth extraction. The method includes the steps of firstly, extracting the volatile oil of securinega suffruticosa, ringworm senna leaves, delavay raspberry and eucommia ulmoides crude powder for standby, and using the herb residues for standby; secondly, crushing magnets for standby; thirdly, soaking magnets, yellow gelatin and polygonatum kingianum with hot water of 50 DEG C for 12 hours, adding water and decocting twice, and combining decoction solution for standby, wherein each decocting takes an hour; performing water extraction and alcohol sedimentation on smallflower parabarium stem, plug blossom, kudzu vine root, rhizoma phragmitis, trifoliateorange bark and the herb residues in the first step to obtain water extract; fifthly, mixing the decoction solution obtained in the third step with the water extract obtained in the fourth step, decompressing and concentrating, freezing and drying, crushing, spraying the volatile oil obtained in the first step, screening with a 100-mesh screen, and split charging. Clinic experiments show that the drug is good in curative effect on relieving bleeding after tooth extraction and is high in safety.

Description

A kind of old people of alleviation has tooth pulled out the preparation method of postoperative hemorrhage medicine

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to a kind of old people of alleviation and have tooth pulled out the preparation method of postoperative hemorrhage medicine.

Background technology

Exodontia is the most frequently used treatment technology of the department of stomatology, and along with the development of science and technology, the progress of medical skill, nowadays the incidence rate of extraction infectious-related complication significantly reduces, but still has generation, is modally postoperative hemorrhage.For gerontal patient, need after exodontia as early as possible artificial tooth to be installed, otherwise absence of tooth can cause alveolar osteanabrosis, affect follow-up artificial tooth and install, cause and chew obstacle.And Repeated Hemorrhage after exodontia, wound surface delayed union, easy secondary hyperosteogeny in alveolus, causes installing artificial tooth, the serious life quality that have impact on old people.Therefore, preventing postoperative hemorrhage, wound healing, is that old people has tooth pulled out the key of post-operative recovery.

But gerontal patient is because of the decline of physical function, the minimizing of heart pump blood volume, whole body blood volume also reduces, and causes dental bed mucosa amount of blood supply to reduce and occurs that repair ability is weak, so there is Repeated Hemorrhage and delayed union.In addition, gerontal patient's possibility long-term taking multi-medicament, with prodrug complex, as anticoagulation, glucocorticoid and NSAID (non-steroidal anti-inflammatory drug) etc. further increase the difficulty of hemostasis.Further, old people, often with multiple chronic disease, especially merges the vitals pathological changes such as the heart, brain, kidney, and it is oral that application haemostatic medicament comprises YUNNAN BAIYAO, can change originally fragile coagulation homeostasis, and hypercoagulability causes cardiovascular and cerebrovascular vessel and occurs unexpectedly.

In prior art, the haemostatic medicaments such as topical application YUNNAN BAIYAO are had to stop blooding, but because patient is often with multiple chronic disease, especially the vitals pathological changes such as the heart, brain, kidney are merged, it is oral that application haemostatic medicament comprises YUNNAN BAIYAO, can change fragile coagulation homeostasis, hypercoagulability causes cardiovascular and cerebrovascular vessel and occurs unexpectedly.And occur Repeated Hemorrhage because the minimizing can not correcting heart pump blood volume causes dental bed mucosa amount of blood supply to reduce and postpone to repair, and the long-term blood coagulation disorders locally taken multi-medicament (as anticoagulation, glucocorticoid and NSAID (non-steroidal anti-inflammatory drug) etc.) and bring, therefore postoperative hemorrhage rate is higher.

Compared with prior art, the present invention has following characteristics:

1, prescription is to spend eucommia vine and Flos Mume for monarch: flower eucommia vine is nontoxic, there is multiple pharmacological action, first local vascular external pressure can be reduced, but vasoconstriction function can not be affected, also the irritability of atrium and ventricle can not be reduced, without exciting ARR hidden danger, secondly, heavy dose of colored eucommia vine also has sedation, people can be made calm, be easy to fall asleep, but be easily waken up after sleeping, therefore the stress stimulation brought after can alleviating extraction and higher nervous activity disturbance state, laboratory result shows, flower eucommia vine Aqueous extracts rat oral gavage (being equivalent to crude drug 1.35g/kg), blood pressure is without change, to Camphora, the convulsions that under the rat cortical that pentetrazole produces, medullary substance excitement that is excited or strychnine generation causes has facilitation.More than spend the dose comparison needed for eucommia vine pharmacological action large, when dosage is larger, easily produce the side reaction such as dizziness, vomiting, heavy dose of Flos Mume of therefore arranging in pairs or groups, can reduce adverse reaction rate, and its action pathway may be relevant with sympathetic nerve effect;

2, get Radix Puerariae, Rubus delavayi Franch., Rhizoma Phragmitis, Flos Mume, enter lung stomach and promote the production of body fluid through antipyretic, prevent dry socket from occurring;

3, get Cortex Ponciri trifoliatae, Flos Mume eleminating phlegm and freeing channels, the Cortex Eucommiae, Rhizoma Polygonati, Magnetitum, in tonify deficiency is real, promote that dental bed portion mucosa is repaired as early as possible;

4, select low dose of Cacumen Securinegae Suffruticosae, Folium Cassiae Alatae using corrigent, Cacumen Securinegae Suffruticosae expelling wind and activating blood circulation, take away entire meaning, the pungent temperature of Folium Cassiae Alatae is dispersed, therefore gets in a small amount;

5, gelatinum oxhide is jelly, and contributing to increases medicine Local Residence Time, and much starch in Rhizoma Polygonati and colloid have synergism equally, avoid using excipient;

6, Magnetitum contains abundant ferrum element, has both contributed to local mucous membrane reparation, has again the effect of tranquillizing the mind by relieving convulsion;

7, avoid in prescription using haemostatic medicament, reduce the danger to cardiovascular and cerebrovascular vessel generation Secondary cases obstructive disease.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, the preparation method of the postoperative hemorrhage medicine that provides a kind of curative effect certainly and the little alleviation old people of side effect has tooth pulled out.

The technical scheme that the present invention solves its technical problem is: filled drug after a kind of old people has tooth pulled out, and it is characterized in that being prepared from by the crude drug of following weight proportion: flower eucommia vine 10 ~ 20 parts, 3 ~ 12 parts, Flos Mume, Rhizoma Phragmitis 3 ~ 12 parts, Radix Puerariae 12 ~ 20 parts, Rubus delavayi Franch. 12 ~ 20 parts, the Cortex Eucommiae 12 ~ 20 parts, Rhizoma Polygonati 12 ~ 20 parts, gelatinum oxhide 3 ~ 12 parts, Cortex Ponciri trifoliatae 10 ~ 25 parts, Magnetitum 1 ~ 2 part, Cacumen Securinegae Suffruticosae 1 ~ 2 part, Folium Cassiae Alatae 1 ~ 5 part.

Chinese medicine of the present invention can be prepared from by following method:

(1) Cacumen Securinegae Suffruticosae, Folium Cassiae Alatae, Rubus delavayi Franch., Cortex Eucommiae coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are for subsequent use;

(2) Magnetitum is pulverized, cross 60 mesh sieves, for subsequent use;

(3) by pulverize in step 2 Magnetitum and gelatinum oxhide, after Rhizoma Polygonati 50 DEG C of hot-water soak 12h, decoct with water 2 times, each 1 hour, collecting decoction was for subsequent use;

(4) the medicinal residues mixing in flower eucommia vine, Flos Mume, Rhizoma Phragmitis, Radix Puerariae, Cortex Ponciri trifoliatae and step 1 is added 4 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 30 minutes, then centrifugal 5 minutes at 20 DEG C, centrifugal liquid removes ethanol, obtains Aqueous extracts;

(5) by after step 3 gained decocting liquid and the mixing of step 4 gained Aqueous extracts, concentrating under reduced pressure, the freezing universe are dry, are sprayed into by gained volatile oil in step 1 after pulverizing, and cross 100 mesh sieves, subpackage forms.

Wherein said: flower eucommia vine is the bark of apocynaceae plant flower hide glue rattan Ecdysanthera utilisHayata etK aw.Bitter; Micro-pungent; Property is put down.Function cures mainly: dispelling wind and removing obstruction in the collateral; Promoting blood circulation and detumescence; Removing toxic substances.Main poliomyelitis sequela; Rheumatic ostalgia; Traumatic injury; Sore.

Flos Mume is the dry flower of rose department plant plum Prunus mume (Sieb.) Sieb. et Zucc..Bitter in the mouth, micro-sweet, micro-acid, cool in nature.Return liver, stomach, lung meridian.Function cures mainly: dispersing the stagnated live-QI to relieve the stagnation of QI, and appetizing is promoted the production of body fluid, and reduces phlegm.

Cortex Ponciri trifoliatae is bark bits or the peel bits of rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirus tuifoliata (L.) Raf..Nature and flavor are pungent; Temperature.Return liver; Kidney channel.Function cures mainly: endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.

Rhizoma Phragmitis is the rhizome of grass phragmites communis.Nature and flavor are sweet, cold.Enter lung, stomach warp.Function cures mainly: lung heat clearing gastric heat, promoting the production of body fluid to quench thirst.

Radix Puerariae is the root of leguminous plant Pachyrhizua angulatus.Sweet, pungent, flat.Enter spleen, stomach warp.Function cures mainly: induce sweat, rash, and relaxing muscles and tendons promotes the production of body fluid, antidiarrheal.

Rubus delavayi Franch. is the Herb of rosaceous plant SANYE Fructus Rubi corchorifolii Immaturus Rubus delavayi Franch..Sweet in the mouth; Micro-acid; Flat.GUIXIN; Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Dehumidifying dysentery relieving; Drive ascarid.

The Cortex Eucommiae is the dry bark of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv..Nature and flavor are sweet, temperature.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.

Rhizoma Polygonati is the dry rhizome of liliaceous plant P. kingianum Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor are sweet, flat.Return spleen, lung, kidney channel.Function cures mainly: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.

Gelatinum oxhide, the glue that the skin for bovid cattle Bos taurus domesticus Gmelin is made.Sweet in the mouth; Property is put down.Return lung; Large intestine channel.Function cures mainly: nourshing Yin and drynsessmoistening prescription; Nourishing blood and hemoslasis; Promoting blood circulation and detumescence; Removing toxic substances.

Magnetitum is oxide-based mineral spinelle race magnetic iron ore, main containing ferroso-ferric oxide (Fe3O4).Nature and flavor are salty, cold.Return liver, the heart, kidney channel.Function cures mainly: suppressing the hyperactive liver and subsiding YANG, hearing-improing and eyesight improving, tranquillizing the mind by relieving convulsion, helping inspiration to relieve asthma.

Folium Cassiae Alatae, is pulse family Folium Cassiae Alatae Cassia alata L., is used as medicine with leaf.Nature and flavor are pungent, temperature.Function cures mainly: parasite killing, antipruritic.

Cacumen Securinegae Suffruticosae is euphorbia plant Suffrutescent Securinega Twig Securinega suffruticosa(Pal1.) browse of Rehd. or root.Acrid in the mouth; Bitter; Slightly warm in nature.Return liver; Kidney; Spleen channel.Function cures mainly: expelling wind and activating blood circulation; The strong muscle of kidney tonifying.

Detailed description of the invention

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, crude drug weight proportion: flower eucommia vine 20g, Flos Mume 12g, Cortex Ponciri trifoliatae 20g, Rhizoma Phragmitis 12g, Radix Puerariae 15g, Rubus delavayi Franch. 15g, Cortex Eucommiae 15g, Rhizoma Polygonati 15g, Magnetitum 1g, gelatinum oxhide 12g, Cacumen Securinegae Suffruticosae 1g, Folium Cassiae Alatae 2g.

The preparation method of embodiment 1 is: will spend eucommia vine, the Cortex Eucommiae, Flos Mume, Rhizoma Phragmitis, Radix Puerariae, Rubus delavayi Franch., Rhizoma Polygonati, Magnetitum (broken), Folium Cassiae Alatae, gelatinum oxhide (broken), Cacumen Securinegae Suffruticosae, Cortex Ponciri trifoliatae mixing and water adding decoct, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, after concentrating under reduced pressure, the freezing universe is dry, pulverized 100 mesh sieves, subpackage forms.Insert in right amount after extraction in alveolus hole, with aseptic cotton balls compacting, within 12 hours, change once, amount to use two days.

Embodiment 2, crude drug weight proportion: flower eucommia vine 10 parts, 3 parts, Flos Mume, Cortex Ponciri trifoliatae 10 parts, Rhizoma Phragmitis 3 parts, Radix Puerariae 12 parts, Rubus delavayi Franch. 12 parts, the Cortex Eucommiae 12 parts, Rhizoma Polygonati 12 parts, Magnetitum 1 part, gelatinum oxhide 3 parts, Cacumen Securinegae Suffruticosae 1 part, Folium Cassiae Alatae 1 part.

Embodiment 3, crude drug weight proportion: flower eucommia vine 20 parts, 12 parts, Flos Mume, Cortex Ponciri trifoliatae 20 parts, Rhizoma Phragmitis 12 parts, Radix Puerariae 15 parts, Rubus delavayi Franch. 15 parts, the Cortex Eucommiae 15 parts, Rhizoma Polygonati 15 parts, Magnetitum 1 part, gelatinum oxhide 12 parts, Cacumen Securinegae Suffruticosae 1 part, Folium Cassiae Alatae 2 parts.

Embodiment 4, crude drug weight proportion: flower eucommia vine 20 parts, 12 parts, Flos Mume, Cortex Ponciri trifoliatae 25 parts, Rhizoma Phragmitis 12 parts, Radix Puerariae 20 parts, Rubus delavayi Franch. 20 parts, the Cortex Eucommiae 20 parts, Rhizoma Polygonati 20 parts, Magnetitum 2 parts, gelatinum oxhide 12 parts, Cacumen Securinegae Suffruticosae 2 parts, Folium Cassiae Alatae 5 parts.

The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:

(1) Cacumen Securinegae Suffruticosae, Folium Cassiae Alatae, Rubus delavayi Franch., Cortex Eucommiae coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are for subsequent use;

(2) Magnetitum is pulverized, cross 60 mesh sieves, for subsequent use;

(3) by pulverize in step 2 Magnetitum and gelatinum oxhide, after Rhizoma Polygonati 50 DEG C of hot-water soak 12h, decoct with water 2 times, each 1 hour, collecting decoction was for subsequent use;

(4) the medicinal residues mixing in flower eucommia vine, Flos Mume, Rhizoma Phragmitis, Radix Puerariae, Cortex Ponciri trifoliatae and step 1 is added 4 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 30 minutes, then centrifugal 5 minutes at 20 DEG C, centrifugal liquid removes ethanol, obtains Aqueous extracts;

(5) by after step 3 gained decocting liquid and the mixing of step 4 gained Aqueous extracts, concentrating under reduced pressure, the freezing universe are dry, are sprayed into by gained volatile oil in step 1 after pulverizing, and cross 100 mesh sieves, subpackage forms.

Insert in right amount after extraction in alveolus hole, with aseptic cotton balls compacting, within 12 hours, change once, amount to use two days.

The efficient combination of said medicine, coordinates mutually, and effectively reach the object controlling exodontia postoperative hemorrhage, after being especially applicable to old people's extraction, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.

1 object and method.

1.1 objects: in March, 2014 ~ 2015 year March age >=Patients 90 example of 60 years old, wherein, man 51 example, female 39 example, 60 ~ 81 years old age, average (68.1 ± 7.4) year.Be divided into matched group 30 example at random, test one group of 29 example, test two group of 31 example, compare on sex, age, underlying diseases before three groups of patient treatments, no significant difference (P>0.05), has comparability.

1.2 method.

1.2.1 Therapeutic Method: the descending extraction of local anaesthesia/conduction block.The compacting of sterilizing cotton balls is filled in matched group alveolus hole.Test one group with gained medicine in the embodiment of the present invention 1, test two groups with gained medicine in the embodiment of the present invention 3, fill in postoperative alveolus hole, the compacting of sterilizing cotton balls.Taking out after three groups of equal 12h, hemorrhagely then continuing the compacting of sterilizing cotton balls as also having, as without hemorrhage, then test one group, test two groups only medicated powder is inserted after, fill with aseptic cotton balls and cover, without the need to compacting, treatment total time is 2 days.

1.2.2 observation index: 1. postoperative 12 hours and 24 hours bleedings; 2. infection rate; 3. alveolus hole healing time.

1.2.3 statistical analysis: SPSS 16.0 carries out statistical analysis.Measurement data t checks, enumeration data χ ²inspection.

2 results.

2.1 postoperative 12 hours and 24 hours bleedings: after compressing 12h and 48h, take out sterilizing cotton balls respectively, wipe wound surface with cotton swab spy and judge bleeding, bleeding sees the following form,

As can be seen from the above table, experiment in 12 hours a group after extraction, the bleeding of testing two groups are obviously less than matched group (χ ²=4.74, P<0.05; χ ²=5.42, P<0.05).Within postoperative 24 hours, internal hemorrhage rate is tested one group, is tested two groups still lower than matched group, but this no significant difference (P>0.05).

2.2 infection rates: matched group, test one group and experiment two groups there is not postextraction infection situation.

2.3 alveolus hole healing times: matched group is (13.0 ± 2.1) d, test one group for (8.9 ± 1.4) d, test two groups for (9.0 ± 1.2) d.Result can be found out, the experiment one group that carrying out stops blooding intervenes and experiment two groups of healing times are obviously faster than matched group (P<0.05).

2.4 3 groups of Patient drug's related reactions incidence rates compare: obvious medicine related reactions does not all appear in three groups of patients, and before and after treatment, hematuria routine, hepatic and renal function, electrocardiogram, blood coagulation biochemical indicator have no significant change.

3. conclusion.

This result of study shows, experiment of the present invention one group and the experiment external used medicine of two groups are filled in local can alleviate bleeding after extraction, and healing time is significantly lower than matched group, illustrate that pharmaceutical composition prepared by the inventive method is alleviating exodontia postoperative hemorrhage, promote that wound healing aspect has effect stability, the advantage that untoward reaction is comparatively light, safety is higher.

Claims (1)

1. alleviate old people and to have tooth pulled out the preparation method of postoperative hemorrhage medicine for one kind, it is characterized in that, be prepared from by the crude drug of following weight proportion: flower eucommia vine, the Cortex Eucommiae, Flos Mume, Cacumen Securinegae Suffruticosae, Rhizoma Phragmitis, Radix Puerariae, Rubus delavayi Franch., Rhizoma Polygonati, Magnetitum, Folium Cassiae Alatae, gelatinum oxhide, Cortex Ponciri trifoliatae; Preparation technology is made up of following steps:

(1) Cacumen Securinegae Suffruticosae, Folium Cassiae Alatae, Rubus delavayi Franch., Cortex Eucommiae coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are for subsequent use;

(2) Magnetitum is pulverized, cross 60 mesh sieves, for subsequent use;

(3) by pulverize in step 2 Magnetitum and gelatinum oxhide, after Rhizoma Polygonati 50 DEG C of hot-water soak 12h, decoct with water 2 times, each 1 hour, collecting decoction was for subsequent use;

(4) the medicinal residues mixing in flower eucommia vine, Flos Mume, Rhizoma Phragmitis, Radix Puerariae, Cortex Ponciri trifoliatae and step 1 is added 4 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 30 minutes, then centrifugal 5 minutes at 20 DEG C, centrifugal liquid removes ethanol, obtains Aqueous extracts;

(5) by after step 3 gained decocting liquid and the mixing of step 4 gained Aqueous extracts, concentrating under reduced pressure, the freezing universe are dry, are sprayed into by gained volatile oil in step 1 after pulverizing, and cross 100 mesh sieves, subpackage forms.