CN104940483A - Traditional Chinese medicine for treating phlegm and blood stagnation type breast hyperplasia, and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating phlegm and blood stagnation type breast hyperplasia, and a preparation method thereof. The raditional Chinese medicine comprises the following raw materials: rhizoma dysosmae versipellis, gracilaria lemaneiformis, frangrant ainsliaea herb, nduoh nyaatv buerng, chorda filum, homlockleaved moonwort, maidenhair, sabina chinensis, hainan ervatamia roots, veronicastrum brunonianum, morinda parvifolia, oyster rhoeo, folium microcotis, wrightia pubescens, fourleaf peperomia herb, arisaema sikokianum Franch., luculia pinceana Hook., and lysimachia congestiflora Hemsl. The traditional Chinese medicine for treating phlegm and blood stagnation type breast hyperplasia has the advantages that the course of treatment is short, the effect can be realized quickly and breast hyperplasia is unlikely to relapse.

Description

A kind of expectorant stasis of blood for the treatment of stagnates the Chinese medicine of type cyclomastopathy and preparation method

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of expectorant stasis of blood for the treatment of and to stagnate the Chinese medicine of type cyclomastopathy and preparation method.

Background technology

Add up according to World Health Organization (WHO): the Women of childbearing age cyclomastopathy sickness rate of 20 ~ 45 years old is up to 50%, global cyclomastopathy patient is more than 1,000,000,000, owing to lacking unified treatment standard and scientific and effective Therapeutic Method at present, the canceration rate of cyclomastopathy is growing, dies from nearly 200,000,000 people of women of cyclomastopathy every year.International breast disease association (SIS) expert calls upon States NGO particular study mechanism for a long time, and strengthens the input to curing mammary gland hyperplasia method and drug research, and early settlement cyclomastopathy cures a difficult problem.

Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.This sick sickness rate was in the trend risen year by year in the last few years, and the age also more and more becomes younger.In adolescence or young women, premenstrual have distending pain of the breast, sometimes pain can involve shoulder back, through the spontaneous remission gradually of rear udder attachment pain, only can contact mammary gland a bit to thicken, without obvious tuberosity, these are that physiological changes, not disease, do not need treatment yet, belong to physiological hypertrophy.Cyclomastopathy is normal breast lobule physiological hypertrophy and subinvolution, and mammary gland normal configuration gets muddled, and belongs to pathological proliferation, and it is neither a class of inflammation non-tumor is again sick.Be mainly in 30-50 year women, onset peak is 35-40 year.

At present, think that cyclomastopathy is relevant with endocrine disturbance and spirit, environmental factors etc. more.

1, endocrine disturbance.Lutein secretion reduces, and it is the major reason that cyclomastopathy is fallen ill that estrogen increases relatively.As unsound in the development of ovary, menoxenia, thyroid disease and hepatic insufficiency etc.

2. the impact of the Nervous and Mental Factors such as emotion.Psychentonia, the bad Nervous and Mental Factors such as excited easily form cyclomastopathy, and often stay up late, do not have enough sleep etc. also can cause cyclomastopathy, and these undesirable elements also can increase the weight of existing cyclomastopathy symptom.

3. anthropic factor or bad life habits: the reasons such as sterile, sexual life imbalance at women advanced age, artificial abortion, man and wife's discord, not suckling, causes mammary gland can not have normally, periodic physiological activity.Wear the medicated bra of tension or pass tight underwear etc.

4. dietary structure is unreasonable, as high fat, high-energy diet cause fat intake too much, to drink and the bad life habits such as smoking can bring out breast disease.In addition, the diet of present people has been got well, and have the people of hypertension, hyperglycemia also a lot, these also easily make women occur endocrine disturbance, cause cyclomastopathy.

5. long-term taking is containing estrogenic health product, contraceptive.The long-term Excess free enthalpy estrogen of human body, will cause incretion balance to be lacked of proper care, and also contain hormonal components, the long-term edible generation that also can cause mastopathy in the Aquatic product of some fast-growing food, artificial breeding and the feedstuff of poultry use now more.

At present, doctor trained in Western medicine is to the primary disease Therapeutic Method that also neither one is more perfect and medicine, hormone is mainly adopted to come treatment-resistant and surgical removal, conventional medicine has 5% potassium iodide and tamoxifen etc., pain severe patient can try out methyl testosterone or tamoxifen, general needs start oral within menstruation the last week, in order to avoid upset the fine balance between human hormone further, because primary disease is a chronic disease, Long-term Hormone class medicine, analgesic effect can only be played, and side effect is large, if performed an operation, damage surface is large, cure the symptoms, not the disease, easily recur again, patient is difficult to accept, medicine majority conventional is clinically Chinese patent medicine, there is the effects such as blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating, hard masses softening and resolving, compensate qi and blood, side effect is little, though therapeutic effect is improved but still not ideal enough, such as ease pill, little gold plaque, nodules of the breast ball, Xi Huan Wan, LIUWEI DIHUANG WAN, ERZHI WAN, XIAOJIN DAN, eliminating stagnation spirit, RUKUAIXIAO capsule, RUZENGNING PIAN, RUKUAIXIAO PIAN, eliminating stagnation nodules of the breast cream etc., but because Chinese patent medicine is for polytype or all types of patient, comprehensive care cannot be accomplished, specific aim is poor, and effect is still not ideal enough.

So, with Therapeutic Method and the medicine of traditional western medical treatment method and single Chinese patent medicine, treat, the effect of pain relieving and relief of symptoms can only be played in early days temporarily, can not tackle the problem at its root, thus cause the recurrent exerbation of disease, a chronic disease of easily examining refractory really of cyclomastopathy, but, as long as a good method and good drug effect can be sought, can cure completely.Though disease one, method for the treatment of is different, although be both cyclomastopathy, but the clinical symptoms that every patient shows is also different, individual difference of stopping is different, can not thousand people one sides, ten thousand people one medicines, regardless of Zhang San, Li Si fixes medication merely, such effectiveness comparison is poor, not only control bad disease, easily recur on the contrary, must according to the ultimate principle of differentiation of tcm when treating primary disease, in conjunction with the different characteristics of morbidity, adopt systematicness, personalized, the concrete medication of the concrete state of an illness, grasp best occasion for the treatment, science is diagnosed, could find out disease root accurately and effectively like this, targeted treatment, patient is avoided detours, spend less, reach a cure.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of expectorant stasis of blood for the treatment of to stagnate the Chinese medicine of type cyclomastopathy and preparation method, and its Chinese medicine to stagnate type cyclomastopathy for the treatment expectorant stasis of blood, by force pointed, good effect, instant effect and the advantage not easily recurred.

Ask to solve above-mentioned technology, the invention provides a kind of expectorant stasis of blood for the treatment of and to stagnate the Chinese medicine of type cyclomastopathy, described Chinese medicine comprises following raw medicinal material: Rhizoma Dysosmae Versipellis, Gracilaria tenuistipitata, Herba Ainsliaeae Fragrantis, Herba Pileae Scriptae, Chorda filum (L.) Stackh., Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Radix Ervatamiae Hainanensis, Folium et cacumen sabinae chinensis, Herba Adianti Flabellulati, Herba Beronicastri brunoniani, Herba Morindae Parvifoliae, Flos Rhoeo discolorae, Folium Microcoris paniculatae, hangs upside down pen, Herba Seu Radix Peperomiae Tetraphyllae, Rhizoma Arisaemati, Dian clove and wind and cold grass.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Rhizoma Dysosmae Versipellis 30 ~ 40 parts, Gracilaria tenuistipitata 15 ~ 25 parts, Herba Ainsliaeae Fragrantis 15 ~ 25 parts, Herba Pileae Scriptae 5 ~ 15 parts, Chorda filum (L.) Stackh. 10 ~ 20 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 30 ~ 40 parts, Radix Ervatamiae Hainanensis 5 ~ 15 parts, Folium et cacumen sabinae chinensis 5 ~ 15 parts, Herba Adianti Flabellulati 10 ~ 20 parts, Herba Beronicastri brunoniani 15 ~ 25 parts, Herba Morindae Parvifoliae 5 ~ 15 parts, Flos Rhoeo discolorae 10 ~ 20 parts, Folium Microcoris paniculatae 10 ~ 20 parts, hangs upside down 15 ~ 25 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 30 ~ 40 parts, Rhizoma Arisaemati 5 ~ 15 parts, Dian clove 15 ~ 25 parts and wind and cold grass 5 ~ 15 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Rhizoma Dysosmae Versipellis 30 ~ 35 parts, Gracilaria tenuistipitata 15 ~ 20 parts, Herba Ainsliaeae Fragrantis 15 ~ 20 parts, Herba Pileae Scriptae 5 ~ 10 parts, Chorda filum (L.) Stackh. 10 ~ 15 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 30 ~ 35 parts, Radix Ervatamiae Hainanensis 5 ~ 10 parts, Folium et cacumen sabinae chinensis 5 ~ 10 parts, Herba Adianti Flabellulati 10 ~ 15 parts, Herba Beronicastri brunoniani 15 ~ 20 parts, Herba Morindae Parvifoliae 5 ~ 10 parts, Flos Rhoeo discolorae 10 ~ 15 parts, Folium Microcoris paniculatae 10 ~ 15 parts, hangs upside down 15 ~ 20 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 30 ~ 35 parts, Rhizoma Arisaemati 5 ~ 10 parts, Dian clove 15 ~ 20 parts and wind and cold grass 5 ~ 10 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Rhizoma Dysosmae Versipellis 32 parts, Gracilaria tenuistipitata 17 parts, Herba Ainsliaeae Fragrantis 18 parts, Herba Pileae Scriptae 6 parts, Chorda filum (L.) Stackh. 12 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 32 parts, Radix Ervatamiae Hainanensis 7 parts, Folium et cacumen sabinae chinensis 8 parts, Herba Adianti Flabellulati 13 parts, Herba Beronicastri brunoniani 18 parts, Herba Morindae Parvifoliae 7 parts, Flos Rhoeo discolorae 13 parts, Folium Microcoris paniculatae 14 parts, hangs upside down 19 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 32 parts, Rhizoma Arisaemati 5 parts, Dian clove 16 parts and wind and cold grass 6 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Rhizoma Dysosmae Versipellis 33 parts, Gracilaria tenuistipitata 19 parts, Herba Ainsliaeae Fragrantis 15 parts, Herba Pileae Scriptae 10 parts, Chorda filum (L.) Stackh. 15 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 35 parts, Radix Ervatamiae Hainanensis 5 parts, Folium et cacumen sabinae chinensis 5 parts, Herba Adianti Flabellulati 10 parts, Herba Beronicastri brunoniani 16 parts, Herba Morindae Parvifoliae 10 parts, Flos Rhoeo discolorae 15 parts, Folium Microcoris paniculatae 10 parts, hangs upside down 15 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 35 parts, Rhizoma Arisaemati 9 parts, Dian clove 20 parts and wind and cold grass 9 parts.

When the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

When the dosage form of described Chinese medicine is unguentum, its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 1 ~ 3 hour, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;

Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;

3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;

4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 30 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.

Beneficial effect of the present invention: Chinese medicine provided by the invention, to stagnate type cyclomastopathy to the treatment expectorant stasis of blood, pointed strong, good effect, instant effect and the advantage not easily recurred.

Detailed description of the invention

The invention provides a kind of expectorant stasis of blood for the treatment of to stagnate the Chinese medicine of type cyclomastopathy, it comprises: Rhizoma Dysosmae Versipellis, Gracilaria tenuistipitata, Herba Ainsliaeae Fragrantis, Herba Pileae Scriptae, Chorda filum (L.) Stackh., Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Radix Ervatamiae Hainanensis, Folium et cacumen sabinae chinensis, Herba Adianti Flabellulati, Herba Beronicastri brunoniani, Herba Morindae Parvifoliae, Flos Rhoeo discolorae, Folium Microcoris paniculatae, hangs upside down pen, Herba Seu Radix Peperomiae Tetraphyllae, Rhizoma Arisaemati, Dian clove and wind and cold grass.

Each herbal pharmacology is as follows:

Rhizoma Dysosmae Versipellis: [another name] rank of nobility rhinoceros, horse order poison is public, nine mortars (" herbal classic "), it mortar, horse order is public, removing toxic substances (" WU Pu Bencao "), art rule grass (" mirror source, red room "), shy variola, shy cold flower (" beneficial portion square object is note slightly "), evil Herba Linderniae Crustaceae (" Bencao Tujing "), anistree dish (" logical will "), Typhonium divaricatum (L.) Decne, only lotus grass (" native Su Bencao "), drought lotus (" pungent beautiful volume in heptan "), unmrellaleaf, anistree mirror (" detailed outline "), Venus is anistree, Herba Hemipiliae Flabellatae (Wang Lianshi " book of gathering medicinal herbs "), Radix Linderae chunii (" Fujian Chinese herbal medicine "), Ligularia nelumbifolia(Bur. et Franch.) Hand.-Mazz., RHIZOMA DIPHYLLEIAE, only He Lian (" Chinese herbal medicine folk recipe and treatment war preparedness special edition "), Herba Typhonii gigantei (" Chinese Higher plant illustrated handbook "), Farfugium japonicum (L) Kitam.Liguaria Kaempferi Kino. (" Acta Pharmaceutica Sinica ").[source] is the rhizome of Berberidaceae plant Radix et Rhizoma Dysosmatis.Autumn excavates.[nature and flavor] toil, flat.[function cures mainly] expectorant powder junction, detoxification and removing stasis.Control consumptive disease wound, cough, spit blood, stomachache, goiter, scrofula, carbuncle, furuncle, traumatic injury, snakebite.[extracts] " Chinese medicine voluminous dictionary "

Gracilaria tenuistipitata: [another name] Thallus Gracilariae, Ottelia acuminata (Gagnep.) Dandy, line dish, ove Notarchi are dry, sea level line, thick bamboo tube dish, oyster dish, deliver vegetables, powder dish.[source] medical material Ji Yuan: be the frond of the true Gracilaria tenuistipitata of Gracilaria tenuistipitata section plant, crisp Gracilaria tenuistipitata, eddo Gracilaria tenuistipitata, phoenix tail dish, Thallus Gracilariae, Gracilaria tenuistipitata, flat Gracilaria tenuistipitata etc.[nature and flavor] are sweet; Salty; Cold; Nontoxic.[function cures mainly] heat clearing away; Resolving phlegm and softening hard masses; Diuretic.Main interior-heat; Expectorant knot goiter; Dysuria.[extracts] " China's book on Chinese herbal medicine "

Herba Ainsliaeae Fragrantis: [another name] Radix Pecteilis susannae (" merciful ferry living person book "), rabbit ear arrow, gold teaspoon (Wang Lianshi " book of gathering medicinal herbs "), fawn holds in the mouth, silver teaspoon, Radix Ophiopogonis is careless, below the moon red (" BAICAO mirror "), rabbit ear Lycoris radiata (" detailed outline is picked up any lost article from the road "), fall to the ground Jin Zhong (" Quanzhou book on Chinese herbal medicine "), Radix Rubi Parvifolii, Herba Tripterospermi, Mao Maxiang, buphthalmos pearl grass, rubber grass (" Hunan medicine will "), macrospecies bar ground fragrant (" medicine investigation is planted in Guizhou "), Herba Veronicae, pull out a thousand pieces of gold, hair Herba Pyrolae, red gold hands over cup, copper spoon, cup handed over by ferrum, Herba Eleocharitis, mountain butterfly, Cor Sus domestica grass, the golden-rimmed grass (" Zhejiang conventional medical herbs among the people ") of the rabbit ear, bar ground tiger, leaf beet, towards sky Herba Anotis ingratae (" Guizhou medical herbs ").[source] is the herb of the fragrant Herba Ainsliaeae Glabrae of feverfew Fructus Pruni.[nature and flavor] are sweet, cold.[return through] " detailed outline is picked up any lost article from the road ": " enter lung meridian." removing heat from blood, removing toxic substances, controls chronic consumptive disease hemoptysis, draws hot jaundice, edema, swollen ulcer drug, scrofula for [function cures mainly] heat clearing away, dampness removing.[extracts] " Chinese medicine voluminous dictionary "

Herba Pileae Scriptae: [another name] Debregeasia orientalis C. J. Chen.[source] Urticaceae Herba Pileae Scriptae Pilea symmeria Wedd.var.salwinensis Hand.-Mazz., with all herbal medicine.[nature and flavor] micro-hardship, puckery, temperature.[function cures mainly] dissipating blood stasis, pain relieving, softening the hard mass, invigorates blood circulation.Cure mainly traumatic injury, osteocarcinoma, fracture.[extracts] " national Chinese herbal medicine compilation "

Chorda filum (L.) Stackh.: [another name] extra large linen thread, rope made of hemp dish, Hai Gazi.[source] medical material Ji Yuan: be the frond of Chorda filum (L.) Stackh. section plant Chorda filum (L.) Stackh..Summer, autumn gather, and clean, dry.[function cures mainly] softening the hard mass; Eliminate the phlegm; Diuresis; Blood pressure lowering.Main scrofula; Goiter; Hypertension.[extracts] " China's book on Chinese herbal medicine "

Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.: [another name] YIDUOYUN (" Shaanxi Chinese herbal medicine ").[source] is the whole herb with root of Botrychiaceae plant Herba pteridii latiusculi Cai.Spring, winter excavate, and dry or using fresh herb.[nature and flavor] " Shaanxi Chinese herbal medicine ": " pained, cool."。[function cures mainly] be " Shaanxi Chinese herbal medicine " 1.: " heat-clearing and toxic substances removing, suppressing the hyperactive liver eliminating stagnation.Control lung abscess, conjunctivitis, impairment caused by overstrain, venom, scrofula."。[extracts] " Chinese medicine voluminous dictionary "

Radix Ervatamiae Hainanensis: [another name] only son and heir wood, taberpsychine tree, Ai Jiaoqing, thunder-crash bomb.[source] Apocynaceae Ervatamia plant Ervatamia hainanensis Ervatamia hainanensis Tsiang, is used as medicine with root and leaf.The whole year can adopt, and cleans and dries.[nature and flavor] are bitter, pungent, cool.Slightly poisonous.[function cures mainly] heat-clearing and toxic substances removing, pain relieving, blood pressure lowering.For hypertension, laryngopharynx swelling and pain, rheumatic arthritis, stomachache, dysentery; Mastitis are controlled in external, furuncle and phyma, venom.[extracts] " national Chinese herbal medicine compilation "

Folium et cacumen sabinae chinensis: [source] is the leaf of Cupressaceae plant Chinese juniper.[nature and flavor] " Fujian traditional herbal medicine ": " pungent, temperature, poisonous." [function cures mainly] expelling wind and cold, promoting blood circulation and detoxication.Control anemofrigid cold, rheumatic arthritis, urticaria, toxic swelling from the beginning of." Fujian Chinese herbal medicine ": " expelling wind and cold, promoting blood circulation and detumescence."。[extracts] " Chinese medicine voluminous dictionary "

Herba Adianti Flabellulati: [another name] Herba cynodontis, black bone awns, seedling occupies grass (" south of the Five Ridges gather medicinal herbs record "), venushair fern, black bone awn winnow basket (" Guangzhou flora "), spiral shell is fainted Herba pteridii latiusculi, black foot Herba pteridii latiusculi, the black Herba pteridii latiusculi of five pawls (" figure will planted by Guangxi medicine "), crow foot rifle (" Luchuan book on Chinese herbal medicine "), spiral shell dimple Herba pteridii latiusculi (" Nanning City's medicine will "), Tie Jiao road dustpan (" Jiangxi traditional herbal medicine "), Tieluji, the crow fly wing, little Fel Ursi (" south of the Five Ridges herbal "), JIZHUALIAN (" Hunan medicine will "), crow foot roadbed, ferrum bamboo strainer (" Jiangxi traditional herbal medicine proved recipe "), ferrum foot wolf beanstalk, two first grass, Herba Abri, crow foot chicken, five pawl Herba pteridii latiusculis, ferrum wolf beanstalk (" Zhejiang conventional medical herbs among the people ").The herb that [source] is adiantaceae plant flabellum venushair fern or rhizome.The whole year can adopt, using fresh herb or dry.[nature and flavor] toil, cool.[function cures mainly] heat clearing away, dampness removing, repercussive, loose swollen.Control acute infectious hepatitis, dysentery, diarrhoea, sand Stranguria, spit blood, have blood in stool, scrofula, traumatic injury, scald, traumatic hemorrhage, furuncle.[extracts] " Chinese medicine voluminous dictionary "

Herba Beronicastri brunoniani: [another name] Radix vernoniae asperae, high mountain Herba Veronicastri caulopteri, cough medicine, YEXIAHONG, Slight Cold medicine, the anti-back of the body are red.[source] medical material Ji Yuan: be the root stock of goatweed Herba Beronicastri brunoniani.[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Preventing phlegm from forming and stopping coughing.Main cough expectorant is yellow; Laryngopharynx swelling and pain; Dysentery; Dribbling urination; Carbuncle sore tumefacting virus.[each discussion] " Xinhua's book on Chinese herbal medicine outline ": root stock.Bitter in the mouth, cold in nature.There are anti-inflammation and sterilization, removing toxic substances, loose swollen function.For tonsillitis, gastric heat pain, cystitis, mastitis, carbuncle sore tumefacting virus, dysentery.[extracts] " China's book on Chinese herbal medicine "

Herba Morindae Parvifoliae: [another name] parthenocissus, cured fish head, five sons, mud rattan grass, large Radix Glycyrrhizae, lobule Radix Morindae Umbellatae.[source] is Rubiaceae bar halberd platymiscium Herba Morindae Parvifoliae Morinda parvifolia Bartl., is used as medicine with Herb.The four seasons can adopt, using fresh herb or dry.[nature and flavor] are sweet, cool.[function cures mainly] clearing away heat-damp and promoting diuresis, preventing phlegm from forming and stopping coughing, eliminating stasis to stop pain.For cold cough, bronchitis, pertussis, diarrhoea, traumatic injury, lumbar muscle strain, eczema.[extracts] " national Chinese herbal medicine compilation "

Flos Rhoeo discolorae: [another name] freshwater mussel flower, purple Flos Rohdeae Japonicae, pocket orchid, the blue clothing of freshwater mussel, Pedicellus et Pericarpium Trapae flower, red Flos Rhoeo discolorae, state army.[source] medical material Ji Yuan: be the flower of the purple Rohdea japonica Roth of Commelianaceae plant.[nature and flavor] are sweet; Cool; Light.[function cures mainly] removing heat from the lung and dissipating phlegm; Cooling blood for hemostasis; Removing toxic substances dysentery relieving.Main lung-heat cough with asthma; Pertussis; Spitting of blood; Epistaxis; Dysentery; Have blood in stool; Scrofula.[extracts] " China's book on Chinese herbal medicine "

Folium Microcoris paniculatae: the precious leaf of [another name] straw rain cape, Folium Microcoris paniculatae, burlap leaf, rotten paniculata, cloth Bao Mu, Microcos paniculata, Collettii.[source] is the leaf of Tiliaceae Folium Microcoris paniculatae platymiscium Microcos paniculata Microcos paniculata..The picking leaves of autumn in summer, dries.[nature and flavor] light, micro-acid, flat.[function cures mainly] clearing away summer-heat, helps digestion, reduces phlegm.For flu, heatstroke, dyspepsia, dyspepsia, diarrhoea.[extracts] " national Chinese herbal medicine compilation "

Hang upside down pen: [another name] Kowloon wood, Mo Zhugen, chapter table root, bitter normal, native Radix Astragali, branch Lignum paulowniae, pig Masson Pine, thin aunt's wood, handle of a knife.[source] Apocynaceae hangs upside down a platymiscium and hangs upside down a Wrightia pubescens R.Brown, is used as medicine with root, root bark and leaf.The whole year can adopt.Root section is dried.Ye Suiyong with adopting, or dries.[nature and flavor] are sweet, flat.[function cures mainly] root: expelling wind and removing dampness, dissipating phlegm and resolving masses.For lymphoid tuberculosis, rheumatic arthritis, lumbago and skelalgia, chronic bronchitis, icterohepatitis, cirrhotic ascites, leucorrhea.Leaf: expelling pathogenic wind from the body surface.For cold, fever.[extracts] " national Chinese herbal medicine compilation "

Herba Seu Radix Peperomiae Tetraphyllae: [another name] Herba Anotis ingratae, Moghania fluminalis(C. B. Clarke) Li lobe, Semen Sojae Preparatum grass, Semen Sojae Preparatum are complied with one's wishes, pintongs Dendrobium nobile Lindl, Herba Stellariae Alsines, Semen Sojae Preparatum DABUSI.[source] Piperaceae peperomia plant Herba Seu Radix Peperomiae Tetraphyllae Peperomia reflexa (L.f.) A.Dietr., with all herbal medicine.The whole year can adopt, using fresh herb or dry.[nature and flavor] micro-hardship, temperature.[function cures mainly] expelling wind and removing dampness, eliminating phlegm and stopping cough, promoting blood circulation and stopping pain.For rheumatism bones and muscles pain, pulmonary tuberculosis, bronchitis, asthma, pertussis, lung abscess, infantile malnutrition, dysmenorrhea; Traumatic injury is controlled in external, fracture.[extracts] " national Chinese herbal medicine compilation "

Rhizoma Arisaemati: [another name] LUBIANHUANG, Serpentis Semen Maydis, old Serpentis Semen Maydis.[source] medical material Ji Yuan: be the tuber of aroid Rhizoma Arisaemati or full edge Rhizoma Arisaemati.[nature and flavor] bitter in the mouth, pungent; Warm in nature; Poisonous.[return through] lung; Liver Channel.[function cures mainly] drying dampness to eliminate phlegm; Relieving spasm by subduing liver-wind; Reducing swelling and alleviating pain.Main productive cough due to phlegm-damp; Dizziness due to wind-phlegm; Epilepsy; Apoplexy; Facial hemiparalysis; Tetanus; Carbuncle; Venom.[extracts] " China's book on Chinese herbal medicine "

Dian clove: [another name] wild fragrant, Fructus cinnamomi immaturus is fragrant, Radix Rhododendri, little Huang tree, Flos Caryophylli, dew globe daisy, MANSHANXIANG, spend wood in vain.[source] medical material Ji Yuan: be the flower, really of Maguireothamnus speciosus Dian clove or strong fragrant Dian clove.[nature and flavor] are pungent; Temperature.[function cures mainly] relieving cough and resolving phlegm.Main cough; Pertussis; Chronic bronchitis.[extracts] " China's book on Chinese herbal medicine "

Wind and cold grass: [another name] is rescued temporarily, Lysimachia christinae Hance, Herba Lysimachiae Congestiflorae, Hu Shi Herba lysimachiae capillipedis, to SHENGHUANG floral leaf, little wind and cold, Herba Lysimachiae Congestiflorae, Hemerocallis citrina Baroni pearl, Liparis plicata Franch .et. Sav, large carbuncle(disease) medicine, climb Radix Rehmanniae Huang.[source] medical material Ji Yuan: be the herb of Ofthe Primulaceae L. congestiflora Hesms.[nature and flavor] are pungent; Micro-hardship; Slightly warm in nature.[function cures mainly] expelling wind and cold; Preventing phlegm from forming and stopping coughing; Detoxification and promoting urination; Removing food stagnancy calculus.Main headche due to wind-cold; Cough with copious phlegm; Laryngopharynx swelling and pain; Jaundice; Biliary Calculi; Lithangiuria; Children's mansion is amassed; Carbuncle furuncle; Venom.[extracts] " China's book on Chinese herbal medicine "

Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be: Rhizoma Dysosmae Versipellis 30 ~ 40 parts, Gracilaria tenuistipitata 15 ~ 25 parts, Herba Ainsliaeae Fragrantis 15 ~ 25 parts, Herba Pileae Scriptae 5 ~ 15 parts, Chorda filum (L.) Stackh. 10 ~ 20 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 30 ~ 40 parts, Radix Ervatamiae Hainanensis 5 ~ 15 parts, Folium et cacumen sabinae chinensis 5 ~ 15 parts, Herba Adianti Flabellulati 10 ~ 20 parts, Herba Beronicastri brunoniani 15 ~ 25 parts, Herba Morindae Parvifoliae 5 ~ 15 parts, Flos Rhoeo discolorae 10 ~ 20 parts, Folium Microcoris paniculatae 10 ~ 20 parts, hang upside down 15 ~ 25 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 30 ~ 40 parts, Rhizoma Arisaemati 5 ~ 15 parts, Dian clove 15 ~ 25 parts and wind and cold grass 5 ~ 15 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be: Rhizoma Dysosmae Versipellis 30 ~ 35 parts, Gracilaria tenuistipitata 15 ~ 20 parts, Herba Ainsliaeae Fragrantis 15 ~ 20 parts, Herba Pileae Scriptae 5 ~ 10 parts, Chorda filum (L.) Stackh. 10 ~ 15 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 30 ~ 35 parts, Radix Ervatamiae Hainanensis 5 ~ 10 parts, Folium et cacumen sabinae chinensis 5 ~ 10 parts, Herba Adianti Flabellulati 10 ~ 15 parts, Herba Beronicastri brunoniani 15 ~ 20 parts, Herba Morindae Parvifoliae 5 ~ 10 parts, Flos Rhoeo discolorae 10 ~ 15 parts, Folium Microcoris paniculatae 10 ~ 15 parts, hangs upside down 15 ~ 20 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 30 ~ 35 parts, Rhizoma Arisaemati 5 ~ 10 parts, Dian clove 15 ~ 20 parts and wind and cold grass 5 ~ 10 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can be: Rhizoma Dysosmae Versipellis 33 parts, Gracilaria tenuistipitata 19 parts, Herba Ainsliaeae Fragrantis 15 parts, Herba Pileae Scriptae 10 parts, Chorda filum (L.) Stackh. 15 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 35 parts, Radix Ervatamiae Hainanensis 5 parts, Folium et cacumen sabinae chinensis 5 parts, Herba Adianti Flabellulati 10 parts, Herba Beronicastri brunoniani 16 parts, Herba Morindae Parvifoliae 10 parts, Flos Rhoeo discolorae 15 parts, Folium Microcoris paniculatae 10 parts, hangs upside down 15 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 35 parts, Rhizoma Arisaemati 9 parts, Dian clove 20 parts and wind and cold grass 9 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can be: Rhizoma Dysosmae Versipellis 32 parts, Gracilaria tenuistipitata 17 parts, Herba Ainsliaeae Fragrantis 18 parts, Herba Pileae Scriptae 6 parts, Chorda filum (L.) Stackh. 12 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 32 parts, Radix Ervatamiae Hainanensis 7 parts, Folium et cacumen sabinae chinensis 8 parts, Herba Adianti Flabellulati 13 parts, Herba Beronicastri brunoniani 18 parts, Herba Morindae Parvifoliae 7 parts, Flos Rhoeo discolorae 13 parts, Folium Microcoris paniculatae 14 parts, hangs upside down 19 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 32 parts, Rhizoma Arisaemati 5 parts, Dian clove 16 parts and wind and cold grass 6 parts.

When the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

When the dosage form of described Chinese medicine is unguentum, its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 1 ~ 3 hour, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;

Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;

3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;

4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 30 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: tablet

Rhizoma Dysosmae Versipellis 330g, Gracilaria tenuistipitata 190g, Herba Ainsliaeae Fragrantis 150g, Herba Pileae Scriptae 100g, Chorda filum (L.) Stackh. 150g, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 350g, Radix Ervatamiae Hainanensis 50g, Folium et cacumen sabinae chinensis 50g, Herba Adianti Flabellulati 100g, Herba Beronicastri brunoniani 160g, Herba Morindae Parvifoliae 100g, Flos Rhoeo discolorae 150g, Folium Microcoris paniculatae 100g, hangs upside down a 150g, Herba Seu Radix Peperomiae Tetraphyllae 350g, Rhizoma Arisaemati 90g, Dian clove 200g and wind and cold grass 90g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 85%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.1 times, 0.05 times of lactose, the starch of 0.1 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.005 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2: unguentum

Rhizoma Dysosmae Versipellis 320g, Gracilaria tenuistipitata 170g, Herba Ainsliaeae Fragrantis 180g, Herba Pileae Scriptae 60g, Chorda filum (L.) Stackh. 120g, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 320g, Radix Ervatamiae Hainanensis 70g, Folium et cacumen sabinae chinensis 80g, Herba Adianti Flabellulati 130g, Herba Beronicastri brunoniani 180g, Herba Morindae Parvifoliae 70g, Flos Rhoeo discolorae 130g, Folium Microcoris paniculatae 140g, hangs upside down a 190g, Herba Seu Radix Peperomiae Tetraphyllae 320g, Rhizoma Arisaemati 50g, Dian clove 160g and wind and cold grass 60g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, decocts with water 4 times, each 2 hours, add the water of 8 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 95% ethanol to alcohol content be 40%, leave standstill 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 2 hours;

Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 3 weight portion stearic acid, 1.5 weight portion stearyl alcohol, 1.5 weight portion glyceryl monostearates, 5 weight portion liquid Paraffin, 10 weight portion dimethicones are mixed and heated to 85 DEG C, under constantly stirring, add 3 part by weight of vitamin E dissolve, obtain oil phase;

1.5 weight portion sodium lauryl sulphates, 0.5 weight portion triethanolamine, 12 weight portion ethyl hydroxybenzoates, 1000 weight portion distilled water relative to mixed-powder described in 100 weight portions that the first step obtains, are mixed and heated to 85 DEG C, obtain aqueous phase by the 3rd step;

4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 31 hours, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 70 DEG C.

Toxicity test:

Acute toxicity testing: be dissolved in distilled water with tablet 1 prepared by the embodiment of the present invention 1, gives white mice feeding dispensing with 140 of clinical consumption per day times, observes 7.The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.

Long term toxicity test: tablet 1 mice of the embodiment of the present invention 1 being prepared is dissolved in water by 9.46g crude drug/kg, continuous use 12 weeks, every day 2 times, and drug withdrawal is after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to test mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: select the expectorant stasis of blood to stagnate outpatient 74 example of type cyclomastopathy, be divided into treatment group and matched group according to random table method.

Treatment group 37 example, 28 ~ 54 years old age, average 42 years old; The course of disease 1 year 2 months ~ 7 years 6 months, one-sided breast morbidity 15 example, bilateral breast morbidity 22 example;

Matched group 37 example, 29 ~ 52 years old age, average 41 years old, the course of disease 1 year 4 months ~ 7 years 4 months, one-sided breast morbidity 17 example, bilateral breast morbidity 20 example; Two groups of data distribute basic simlarity in age, the course of disease, the state of an illness, have comparability.

Diagnostic criteria: the diagnostic criteria with reference to " surgery " cyclomastopathy: 1) pain appears in one-sided or bilateral breast, majority has periodically, and show effect relevant with menstrual cycle, menstruation a few days ago pain increases the weight of, and alleviates or disappear after menstrual onset; 2) health check-up finds side or bilateral breast body of gland limitation or diffuse thickening, and lump be graininess, not of uniform size, and matter is tough and not firmly, buildup area and surrounding normal mammary gland tissue are demarcated unclear; 3) the primary disease course of disease is longer, and slower development is apt to occur in middle-aged women; 4) small number of patients can be associated with nipple discharge, is serosity or slurry courage and uprightness, if any above-mentioned more than two persons, can confirms as primary disease.Utilize the auxiliary detection means such as molybdenum target x line, B ultrasonic, thermal image figure if desired, or row lump Needle-sucking cytology checks and local living tissue pathologic finding, to get rid of other good, malignant disease such as breast carcinoma, mammary gland fibroma.

Syndrome Differentiation of Traditional Chinese Medicine standard: the expectorant stasis of blood stagnates type: patient's chest prolonged difficulty of luming disappears, and distending pain or twinge, the lump quality touched is comparatively hard, and mobility is poor.Patient is abundant expectoration at ordinary times, matter thickness, irritable, insomnia and dreamful sleep, exacerbation of symptoms during anxious state of mind, and few through row amount, color is dim, has clot concurrently, abdominal pain during menstruation.Body of the tongue is dim red or have petechia, thready and hesitant pulse.

Curative effect judging standard: " the Chinese medical disease Standardization of diagnosis and curative effect " worked out according to the State Administration of Traditional Chinese Medicines is drafted.Clinical cure: pain and lump all disappear, nipple without discharge and maintain 6 months persons; Effective: pain disappears, and the lump thickened softens and scatters, and mass reduction is greater than 50%; Effective: pain is obviously alleviated, lump deliquescing, mass reduction is less than 50%; Invalid: pain is without alleviation, and Tumor size, quality are without change.

Therapeutic Method:

Treatment group: the tablet taking the embodiment of the present invention 1, every day 3 times times, each 41 month is 1 course for the treatment of, takes 2 courses for the treatment of.The irritable foods such as period in a medicine fasting is raw and cold, greasy, pungent.

Matched group: take RUKUAIXIAO PIAN (Taisho Pharmaceutical, the accurate word Z61021184 of traditional Chinese medicines), every day 3 times, each 61 month is 1 course for the treatment of, takes 2 courses for the treatment of.The irritable foods such as period in a medicine fasting is raw and cold, greasy, pungent.

Therapeutic outcome: see the following form.

After table 1 liang group treats 2 courses for the treatment of respectively, total effects statistics is as follows:

Group	n	Clinical cure	Effective	Effectively	Invalid	Effectively total
							Treatment group	37	26	6	5	0	37(100％)
Matched group	37	13	10	6	8	29(78.4％)

As known from Table 1, treatment group curative effect is better than matched group (P<0.05), and namely adopt Chinese medicine of the present invention to treat, its curative effect will significantly better than matched group.In addition, treatment group, after within 6 months, being judged to be clinical cure to 26 routine clinical cure patient drug withdrawals, continue to follow up a case by regular visits to half a year, result is without recurrence, and relapse rate is 0%.Matched group continues to follow up a case by regular visits to half a year, recurs 2 people, relapse rate 15.4% after within 6 months, being judged to be clinical cure to 13 routine clinical cure patient drug withdrawals.

The healing time statistics of table 2 liang group clinical cure patient is as follows:

Group	n	Treat 20 days	Treat 40 days	Treat 60 days
					Treatment group	26	8(21.6％)	22(59.5％)	26(70.3％)
Matched group	13	1(2.7％)	7(18.9％)	13(35.1％)

As known from Table 2, adopt Chinese medicine of the present invention to treat, its treatment time will be significantly shorter than treatment time of matched group, and namely Chinese medicine of the present invention takes effect faster, and treatment is shorter for the course for the treatment of.

Model case: to certain, female, 45 years old, patient's chest lumpd 6 years, and prolonged difficulty disappears, distending pain or twinge, and the lump quality touched is comparatively hard, and mobility is poor.Patient is abundant expectoration at ordinary times, matter thickness, irritable, insomnia and dreamful sleep, exacerbation of symptoms during anxious state of mind, and few through row amount, color is dim, has clot concurrently, abdominal pain during menstruation.Body of the tongue is dim red, thready and hesitant pulse.Bilateral breast hypertrophy is diagnosed as through the film making of molybdenum target x line.The expectorant stasis of blood belonged in the traditional Chinese medical science stagnates type cyclomastopathy, take the tablet of the embodiment of the present invention 1, every day 3 times, each 4,30 days pain of taking medicine obviously alleviates, sputum obviously reduces, and emotion and sleep greatly take a turn for the better, and continue to take to 40 days, two swelling of the breast block and pain all disappear, all the other all diseases all disappear, drug withdrawal, follow up a case by regular visits to and do not recur for 1 year.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat the expectorant stasis of blood to stagnate the Chinese medicine of type cyclomastopathy, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Rhizoma Dysosmae Versipellis, Gracilaria tenuistipitata, Herba Ainsliaeae Fragrantis, Herba Pileae Scriptae, Chorda filum (L.) Stackh., Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Radix Ervatamiae Hainanensis, Folium et cacumen sabinae chinensis, Herba Adianti Flabellulati, Herba Beronicastri brunoniani, Herba Morindae Parvifoliae, Flos Rhoeo discolorae, Folium Microcoris paniculatae, hangs upside down pen, Herba Seu Radix Peperomiae Tetraphyllae, Rhizoma Arisaemati, Dian clove and wind and cold grass.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Rhizoma Dysosmae Versipellis 30 ~ 40 parts, Gracilaria tenuistipitata 15 ~ 25 parts, Herba Ainsliaeae Fragrantis 15 ~ 25 parts, Herba Pileae Scriptae 5 ~ 15 parts, Chorda filum (L.) Stackh. 10 ~ 20 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 30 ~ 40 parts, Radix Ervatamiae Hainanensis 5 ~ 15 parts, Folium et cacumen sabinae chinensis 5 ~ 15 parts, Herba Adianti Flabellulati 10 ~ 20 parts, Herba Beronicastri brunoniani 15 ~ 25 parts, Herba Morindae Parvifoliae 5 ~ 15 parts, Flos Rhoeo discolorae 10 ~ 20 parts, Folium Microcoris paniculatae 10 ~ 20 parts, hang upside down 15 ~ 25 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 30 ~ 40 parts, Rhizoma Arisaemati 5 ~ 15 parts, Dian clove 15 ~ 25 parts and wind and cold grass 5 ~ 15 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Rhizoma Dysosmae Versipellis 30 ~ 35 parts, Gracilaria tenuistipitata 15 ~ 20 parts, Herba Ainsliaeae Fragrantis 15 ~ 20 parts, Herba Pileae Scriptae 5 ~ 10 parts, Chorda filum (L.) Stackh. 10 ~ 15 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 30 ~ 35 parts, Radix Ervatamiae Hainanensis 5 ~ 10 parts, Folium et cacumen sabinae chinensis 5 ~ 10 parts, Herba Adianti Flabellulati 10 ~ 15 parts, Herba Beronicastri brunoniani 15 ~ 20 parts, Herba Morindae Parvifoliae 5 ~ 10 parts, Flos Rhoeo discolorae 10 ~ 15 parts, Folium Microcoris paniculatae 10 ~ 15 parts, hang upside down 15 ~ 20 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 30 ~ 35 parts, Rhizoma Arisaemati 5 ~ 10 parts, Dian clove 15 ~ 20 parts and wind and cold grass 5 ~ 10 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Rhizoma Dysosmae Versipellis 33 parts, Gracilaria tenuistipitata 19 parts, Herba Ainsliaeae Fragrantis 15 parts, Herba Pileae Scriptae 10 parts, Chorda filum (L.) Stackh. 15 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 35 parts, Radix Ervatamiae Hainanensis 5 parts, Folium et cacumen sabinae chinensis 5 parts, Herba Adianti Flabellulati 10 parts, Herba Beronicastri brunoniani 16 parts, Herba Morindae Parvifoliae 10 parts, Flos Rhoeo discolorae 15 parts, Folium Microcoris paniculatae 10 parts, hangs upside down 15 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 35 parts, Rhizoma Arisaemati 9 parts, Dian clove 20 parts and wind and cold grass 9 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Rhizoma Dysosmae Versipellis 32 parts, Gracilaria tenuistipitata 17 parts, Herba Ainsliaeae Fragrantis 18 parts, Herba Pileae Scriptae 6 parts, Chorda filum (L.) Stackh. 12 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 32 parts, Radix Ervatamiae Hainanensis 7 parts, Folium et cacumen sabinae chinensis 8 parts, Herba Adianti Flabellulati 13 parts, Herba Beronicastri brunoniani 18 parts, Herba Morindae Parvifoliae 7 parts, Flos Rhoeo discolorae 13 parts, Folium Microcoris paniculatae 14 parts, hangs upside down 19 parts, pen, Herba Seu Radix Peperomiae Tetraphyllae 32 parts, Rhizoma Arisaemati 5 parts, Dian clove 16 parts and wind and cold grass 6 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.05 ~ 0.15 times, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 1 ~ 3 hour, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;

Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;

3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;

4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 30 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.

8. a preparation method for the Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.05 ~ 0.15 times, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.

9. a preparation method for the Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, decocts with water 2 ~ 4 times, each 1 ~ 3 hour, add the water of 6 ~ 10 times amount, decoction liquor is filtered at every turn, merge the filtrate of each time, add determining alcohol be 90% ~ 95% ethanol to alcohol content be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate concentrates, and drying is also pulverized, and obtains mixed-powder, cross 200 mesh sieves, adopt ultra violet lamp sterilizing in 1 ~ 2 hour;

Second step, relative to mixed-powder described in 100 weight portions that the first step obtains, 1 weight portion ~ 3 weight portion stearic acid, 0.5 weight portion ~ 1.5 weight portion stearyl alcohol, 0.5 weight portion ~ 1.5 weight portion glyceryl monostearate, 3 weight portion ~ 5 weight portion liquid Paraffin, 8 weight portion ~ 10 weight portion dimethicones are mixed and heated to 75 DEG C ~ 85 DEG C, under constantly stirring, add 1 weight portion ~ 3 part by weight of vitamin E dissolve, obtain oil phase;

3rd step, relative to mixed-powder described in 100 weight portions that the first step obtains, 0.5 weight portion ~ 1.5 weight portion sodium lauryl sulphate, 0.5 weight portion ~ 1.5 weight portion triethanolamine, 1 weight portion ~ 2 weight portion ethyl hydroxybenzoate, 1000 weight portion ~ 1500 weight portion distilled water are mixed and heated to 75 DEG C ~ 85 DEG C, obtain aqueous phase;

4th step, the oil phase obtained by second step slowly adds in the aqueous phase of the 3rd step acquisition under constantly stirring, and fully stirs 30 minutes ~ 1 hour, makes emulsifying, add the mixed-powder that the first step obtains, stir, subpackage at the temperature of 60 DEG C ~ 70 DEG C.