CN104940405B - A kind of Xiaoer Qingyan Granule and preparation method thereof - Google Patents
A kind of Xiaoer Qingyan Granule and preparation method thereof Download PDFInfo
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- CN104940405B CN104940405B CN201510426782.XA CN201510426782A CN104940405B CN 104940405 B CN104940405 B CN 104940405B CN 201510426782 A CN201510426782 A CN 201510426782A CN 104940405 B CN104940405 B CN 104940405B
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- 239000008187 granular material Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000000706 filtrate Substances 0.000 claims abstract description 58
- 239000000284 extract Substances 0.000 claims abstract description 51
- 239000006071 cream Substances 0.000 claims abstract description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 50
- 241000576429 Forsythia suspensa Species 0.000 claims abstract description 42
- 239000002775 capsule Substances 0.000 claims abstract description 42
- 239000000843 powder Substances 0.000 claims abstract description 40
- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 39
- 244000246386 Mentha pulegium Species 0.000 claims abstract description 39
- 235000016257 Mentha pulegium Nutrition 0.000 claims abstract description 39
- 235000004357 Mentha x piperita Nutrition 0.000 claims abstract description 39
- 235000001050 hortel pimenta Nutrition 0.000 claims abstract description 39
- 240000005528 Arctium lappa Species 0.000 claims abstract description 37
- 239000010231 banlangen Substances 0.000 claims abstract description 36
- 239000002245 particle Substances 0.000 claims abstract description 33
- 241000931705 Cicada Species 0.000 claims abstract description 29
- 239000000341 volatile oil Substances 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 21
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims abstract description 17
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 16
- 229930006000 Sucrose Natural products 0.000 claims abstract description 16
- 239000005720 sucrose Substances 0.000 claims abstract description 16
- 239000004375 Dextrin Substances 0.000 claims abstract description 15
- 229920001353 Dextrin Polymers 0.000 claims abstract description 15
- 235000019425 dextrin Nutrition 0.000 claims abstract description 15
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 59
- 239000003814 drug Substances 0.000 claims description 51
- 239000007788 liquid Substances 0.000 claims description 36
- 229940079593 drug Drugs 0.000 claims description 35
- 238000001914 filtration Methods 0.000 claims description 30
- 239000006228 supernatant Substances 0.000 claims description 22
- 238000009835 boiling Methods 0.000 claims description 19
- 238000001035 drying Methods 0.000 claims description 19
- 238000005469 granulation Methods 0.000 claims description 13
- 230000003179 granulation Effects 0.000 claims description 13
- 241000245665 Taraxacum Species 0.000 claims description 12
- 241000322338 Loeseliastrum Species 0.000 claims description 11
- 238000011049 filling Methods 0.000 claims description 11
- 238000001256 steam distillation Methods 0.000 claims description 11
- 238000004821 distillation Methods 0.000 claims description 10
- 238000005119 centrifugation Methods 0.000 claims description 7
- 238000012856 packing Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 6
- 206010011224 Cough Diseases 0.000 claims description 4
- 206010000269 abscess Diseases 0.000 claims description 3
- AZHSSKPUVBVXLK-UHFFFAOYSA-N ethane-1,1-diol Chemical compound CC(O)O AZHSSKPUVBVXLK-UHFFFAOYSA-N 0.000 claims description 3
- 206010037660 Pyrexia Diseases 0.000 claims description 2
- 241000208843 Arctium Species 0.000 claims 2
- 235000008078 Arctium minus Nutrition 0.000 claims 2
- 239000012141 concentrate Substances 0.000 claims 2
- 238000002386 leaching Methods 0.000 claims 2
- 206010019233 Headaches Diseases 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 18
- 238000000605 extraction Methods 0.000 abstract description 12
- 238000005516 engineering process Methods 0.000 abstract description 10
- 239000004480 active ingredient Substances 0.000 abstract description 6
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 240000001949 Taraxacum officinale Species 0.000 abstract description 2
- 238000004062 sedimentation Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000009102 absorption Effects 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
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- 239000011780 sodium chloride Substances 0.000 description 3
- 240000005001 Paeonia suffruticosa Species 0.000 description 2
- 235000003889 Paeonia suffruticosa Nutrition 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000000686 essence Substances 0.000 description 2
- -1 filtration Substances 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
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- 244000269722 Thea sinensis Species 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
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Abstract
The present invention discloses a kind of Xiaoer Qingyan Granule.The preparation method of the particle is to take the Radix Isatidis and capsule of weeping forsythia crushing fine powder of 1/3 amount；Radix scrophulariae and cicada slough crush to obtain fine powder；The Radix Isatidis water decoction-alcohol sedimentation of remaining 2/3 amount obtains clear cream A；The capsule of weeping forsythia of remainder 2/3 is separated into obtain medicinal extract B with decocting；Great burdock achene and peppermint are put into extraction volatile oil C；Great burdock achene and the decocting of the peppermint dregs of a decoction are filtered, obtain filtrate D；Dandelion, moutan bark and indigo naturalis decocting are obtained into filtrate, filtrate merges with great burdock achene and peppermint filtrate D is concentrated to give clear cream E；Clear cream A, medicinal extract B, volatile oil C and clear cream E are stirred, it is well mixed that medicinal extract, addition sucrose and dextrin are pelletized to add Radix Isatidis, the capsule of weeping forsythia, radix scrophulariae and cicada slough fine powder.The invention has the advantages that technique its extracts active ingredients after improvement more completely, content is higher, stability is more preferable, and the auxiliary material addition of the preparation technology after improving greatly is reduced than the auxiliary material of active compound allusion quotation technique, while can also reduce the dose of patient.
Description
Technical field
The present invention relates to a kind of pharmaceutical formulation of field of medicaments, more particularly to a kind of Xiaoer Qingyan Granule and its preparation side
Method.
Background technology
Xiaoer Qingyan Granule is that Chinese Pharmacopoeia records kind.By radix scrophulariae, dandelion, great burdock achene, peppermint, cicada slough, Radix Isatidis,
The capsule of weeping forsythia, moutan bark and indigo naturalis are prepared, and have relieving superficies by cooling, relieving sore-throat of detoxifying.For fever head caused by treating cold due to wind-heat
Bitterly, sound of coughing is mute, abscess of throat.
Xiaoer Qingyan Granule preparation technology is substantially the method for continuing to use traditional decoction at present, and peppermint extracts volatile oil, other
Bulk drug decocts together.Due to mixing extraction or decoct, the effective ingredient of its single bulk drug can be promoted unstable, and bulk drug
The recovery rate that mixing decocts effective ingredient can also substantially reduce, and also inevitably propose a large amount of water-solubility impurities.Traditional Chinese medicine disease prevention
The effect and the amount of extract and the content of wherein active ingredient cured the disease have direct relation.If extraction process is unreasonable, not section
Learn, the destruction and loss of active ingredient certainly will be caused, so as to influence the quality of preparation, curative effect.
As clinically to drug quality, the continuous improvement of effect requirements and the continuous development of pharmaceutical technology, the technique is
Current demand can not be met, be badly in need of the preparation process that a kind of extracts active ingredients are more complete, content is higher, it is small preferably to play
The medical value of youngster's Qingyan Granules classics prescription.
The content of the invention
The purpose of the present invention is to be directed to the deficiencies in the prior art, there is provided a kind of extracts active ingredients are more complete, contain
Higher, the more preferable Xiaoer Qingyan Granule of stability is measured, so as to preferably play the medical value of traditional proved recipe.
Present invention aims at provide a kind of preparation method of Xiaoer Qingyan Granule.
The present invention is achieved through the following technical solutions：
Xiaoer Qingyan Granule of the present invention is made up of the following raw material medicine and preparation method：
Bulk drug forms：
Preparation method is：
Take the Radix Isatidis of 1/3 amount and the capsule of weeping forsythia of 1/3 amount to clean, dry respectively, crush to obtain fine powder；Radix scrophulariae and cicada slough are distinguished
Clean, drying, crush to obtain fine powder；The Radix Isatidis of remaining 2/3 amount is cleaned, secondary, first time is boiled with the 4-12 times of decocting measured
1.5-2.5 hours, second of 1-2 hour, merge decocting liquid twice, filtration, filtrate is concentrated into 60-100 DEG C of survey relative density and is
1.15-1.18, ethanol is added alcohol content is stood up to 65%, is taken supernatant to reclaim ethanol, and it is relatively close to be concentrated into 60-100 DEG C of survey
Spend the clear cream A for 1.25-1.30；The capsule of weeping forsythia of remainder 2/3 is cleaned with clear water, adds the 4-12 times of decocting measured to boil secondary, for the first time
1.5-2.5 hours, second of 1-2 hour, merge decocting liquid twice, filtering, filtrate centrifuges, and 3000rpm centrifugations, separates supernatant
Liquid, water bath method are concentrated into 1.25-1.30 medicinal extract B；Great burdock achene and peppermint are put in extractor, add 4-12 times to measure water, is soaked
2-4 days laggard water-filling steam distillations, the timing distillation 1.5-4.5 hours since boiling, collect volatile oil C；By great burdock achene and thin
The lotus dregs of a decoction add 3-9 times of crude drug and measure water, and decoction 0.5-1.5 hours release decoction, 80 mesh screens, obtain filtrate D；Pu is public
English, moutan bark and the indigo naturalis of dividing three guarantees to be wrapped with calico add 4-12 times to measure decocting to boil twice, each 0.5-1.5 hours, merge two
Secondary decocting liquid, filtration, filtrate merge with above-mentioned great burdock achene and peppermint filtrate D, are well mixed, and it is relatively close to be concentrated into 40-60 DEG C of heat survey
Spend the clear cream E for 1.35~1.40；Clear cream A, medicinal extract B, volatile oil C and clear cream E are stirred uniformly with homogenizer, then
Add Radix Isatidis, the capsule of weeping forsythia, radix scrophulariae and cicada slough fine powder and medicinal extract is mixed evenly to obtain, add sucrose 250-750 parts by weight, dextrin
70% alcohol granulation of 130-390 parts by weight, particle fluidized drying in boiling drier produce.
Above-mentioned 1/3 amount Radix Isatidis, the 1/3 amount capsule of weeping forsythia, radix scrophulariae and cicada slough preferably crushed 80 mesh sieves with high speed disintegrator.
The bulk drug of Xiaoer Qingyan Granule of the present invention forms：
The bulk drug of Xiaoer Qingyan Granule of the present invention forms：
The bulk drug of Xiaoer Qingyan Granule of the present invention forms：
The preparation method of Xiaoer Qingyan Granule of the present invention is preferably：The Radix Isatidis of 1/3 amount and the capsule of weeping forsythia of 1/3 amount is taken to wash respectively
Only, dry, crushed 80 mesh sieves with high speed disintegrator and obtain fine powder；Radix scrophulariae and cicada slough are cleaned respectively, dried, uses high speed disintegrator
It crushed 80 mesh sieves and obtain fine powder；The Radix Isatidis of remaining 2/3 amount is cleaned, boiled with the decocting of 8 times of amounts secondary, 2 hours first times, the
Secondary 1.5 hours, merge decocting liquid twice, filtration, it is 1.15-1.18 that filtrate, which is concentrated into 80 DEG C and surveys relative density, adds ethanol to make to contain
Alcohol amount stands up to 65%, takes supernatant to reclaim ethanol, and be concentrated into 80 DEG C and survey the clear cream A that relative density is 1.25-1.30；Will
The capsule of weeping forsythia of remainder 2/3 is cleaned with clear water, is added the decocting of 8 times of amounts to boil secondary, 2 hours first times, second 1.5 hours, is merged two
Secondary decocting liquid, filtering, filtrate centrifuge, and 3000rpm centrifugations, separate supernatant, water bath method is concentrated into 1.25-1.30 medicinal extract
B；Great burdock achene and peppermint are put in extractor, adds 8 times of amount water, soaks 3 days laggard water-filling steam distillations, the timing steaming since boiling
Evaporate 3 hours, collect volatile oil C；Great burdock achene and the peppermint dregs of a decoction are added into 6 times of amount water of crude drug, decocts and releases within 1 hour decoction, 80
Mesh screen, obtain filtrate D；8 times of amount decoctings are added to boil twice dandelion, moutan bark and the indigo naturalis of dividing three guarantees to be wrapped with calico, often
Secondary 1 hour, merge decocting liquid twice, filtration, filtrate merges with above-mentioned great burdock achene and peppermint filtrate D, is well mixed, is concentrated into 50 DEG C
Heat surveys the clear cream E that relative density is 1.35~1.40；Clear cream A, medicinal extract B, volatile oil C and clear cream E are carried out with homogenizer
Stir, add Radix Isatidis, the capsule of weeping forsythia, radix scrophulariae and cicada slough fine powder and medicinal extract is mixed evenly to obtain, add the weight of sucrose 500
Part, 70% alcohol granulation of the parts by weight of dextrin 260, particle fluidized drying in boiling drier produce.
Xiaoer Qingyan Granule of the present invention is made up of the following raw material medicine and preparation method：
The parts by weight are using g as unit of account；
Bulk drug forms：
Preparation method is：
Take the Radix Isatidis of 1/3 amount and the capsule of weeping forsythia of 1/3 amount to clean, dry respectively, crushed 80 mesh sieves with high speed disintegrator and obtain
Fine powder；Radix scrophulariae and cicada slough are cleaned respectively, dried, crushed 80 mesh sieves with high speed disintegrator and obtain fine powder；By the plate of remaining 2/3 amount
Blue root is cleaned, and is boiled with the decocting of 8 times of amounts secondary, 2 hours first times, second 1.5 hours, merges decocting liquid twice, filtration, filtrate
It is 1.15-1.18 to be concentrated into 80 DEG C and survey relative densities, adds ethanol to make alcohol content up to 65%, stands, and takes supernatant recovery ethanol, and
It is concentrated into 80 DEG C and surveys the clear cream A that relative density is 1.25-1.30；The capsule of weeping forsythia of remainder 2/3 is cleaned with clear water, adds the water of 8 times of amounts
Decoct secondary, 2 hours for the first time, second 1.5 hours, merge decocting liquid twice, filtering, filtrate centrifuges, 3000rpm from
The heart, separates supernatant, and water bath method is concentrated into 1.25-1.30 medicinal extract B；Great burdock achene and peppermint are put in extractor, add 8 times of amounts
Water, 3 days laggard water-filling steam distillations are soaked, timing distillation 3 hours, collect volatile oil C since boiling；By great burdock achene and peppermint
The dregs of a decoction add 6 times of amount water of crude drug, decoct 1 hour and release decoction, 80 mesh screens, obtain filtrate D；By dandelion, moutan bark and
The indigo naturalis that point three guarantees are wrapped with calico adds 8 times of amount decoctings to boil twice, 1 hour every time, merges decocting liquid twice, filtration, filtrate with it is upper
State great burdock achene and peppermint filtrate D merges, be well mixed, be concentrated into 50 DEG C of heat and survey the clear cream E that relative density is 1.35~1.40；Will
Clear cream A, medicinal extract B, volatile oil C and clear cream E are stirred uniformly with homogenizer, add Radix Isatidis, the capsule of weeping forsythia, radix scrophulariae and cicada
Slough off fine powder and medicinal extract is mixed evenly to obtain, add 70% alcohol granulation of sucrose 500g, dextrin 260g, particle is in fluidized drying
Fluidized drying in machine, is made particle 1080g, and packing specification is 3g/ bags.
Indigo naturalis in bulk drug of the present invention is to decoct a drug wrapped.
Inventor is had found in screening process, and only the capsule of weeping forsythia of the Radix Isatidis of 1/3 amount and 1/3 amount is used as medicine with fine powder, its
Remaining the Radix Isatidis of 2/3 amount and the capsule of weeping forsythia of 2/3 amount is used as medicine in the form of extract, obtained yield highest, effect is best, if low
It is used as medicine in 1/3 amount in the form of raw material fine powder, yield improves unobvious, is used as medicine higher than 1/3 raw material fine powder, manufactured granule can not
Reach defined specification, and granulating efficiency is bad.Another inventor has found to wear into radix scrophulariae and cicada slough carefully also in screening process
Powder, which is used as medicine, can not only reach the requirement of granulation, and granulating efficiency is good, and decocting extraction yield is too low, and efficacy component is unstable.
Bulk drug is merged to decoction together simultaneously, can mutually destroy effective ingredient so that effective ingredient is unstable, and yield is low.
The advantages of children's clearing pellet of the present invention is, the technique after improvement its extracts active ingredients more completely, content more
Height, stability are more preferable, and the auxiliary material addition of the preparation technology after improvement is greatly reduced than the auxiliary material of active compound allusion quotation technique, simultaneously
The dose of patient can also be reduced.
Experimental example is used to further illustrate the present invention below, but is not limited to the present invention.
Experimental example one：Orthogonal test
1. preparation technology screens：
Control group：
Preparation technology：The taste of the above nine, peppermint extraction volatile oil, the another device of the aqueous solution after distillation are collected；Remaining radix scrophulariae etc. eight
Taste, adds water to cook secondary, and 1 hour every time, collecting decoction, filtration, filtrate merged with the above-mentioned aqueous solution, and being concentrated into relative density is
The clear cream of 1.25~1.30 (50 DEG C of heat are surveyed).1 part of qinghuo reagent, 3.5 parts of sucrose, 0.5 part of essence essences, 1080g particles are made, dry,
Above-mentioned peppermint oil is added, is mixed, both.
Of the present invention group：(being prepared according to the preparation technology of embodiment 1)
2nd, extraction process effective ingredient yield contrast table：
Table 1
| Group | Bulk drug g | Bulk drug medicinal extract g | Active compound material extraction composition yield (%) |
| Control group | 700 | 216 | 30.86% |
| Of the present invention group | 700 | 380 | 54.29% |
Conclusion：Control group extraction process, the extraction yield of last bulk drug is 30.86%, and present invention group preparation technology is former
Expect that medicine extraction yield is 54.29%, there were significant differences with control group bulk drug extraction yield for present invention group bulk drug extraction yield.
3rd, the amount ratio of bulk drug and auxiliary material compared with
Table 2
| Group | Sucrose g | Dextrin g | Bulk drug medicinal extract g | The ratio of bulk drug medicinal extract and auxiliary material is about |
| Control group | 756 | 108 | 216 | 1:4 |
| Of the present invention group | 500 | 260 | 380 | 1:2 |
Conclusion：The bulk drug medicinal extract of control group preparation technology and the ratio of auxiliary material are 1：4, the present invention group bulk drug medicinal extract with it is auxiliary
The ratio of material is 1:2, the auxiliary material composition of control group is significantly greater than present invention group auxiliary material composition, and auxiliary material compares that there were significant differences.
4th, instructions of taking and drug effect compare
Statistics 200 is used for children and feels heating pain caused by wind-heat, and cough sound is mute, and abscess of throat children, the age is in 1-5
In year, wherein 100 are taken control group medicine, another 100 patients take present invention group medicine, and instructions of taking and curative effect are as follows：
Table 3
| Group | Number | Day/time | Each taking dosage | Take number of days | Total effective rate |
| Control group | 100 people | 3 times | 6g | 7 | 94% |
| Of the present invention group | 100 people | 3 times | 3g | 7 | 98% |
Conclusion：Control group daily 3 times, it is 6g each taking dosage, present invention group daily 3 times, each taking dosage
For 3g.Present invention group dose relatively has aobvious person's difference with control group.Present invention group treatment total effective rate and control group treatment are total
Effective percentage is relatively not significantly different.
5th, stability test is studied
5.1 medicinal extract of the present invention (are prepared, step is soaked to any auxiliary material, simple medicine is not added with according to the method for embodiment 1
Cream), auxiliary material selects sucrose and dextrin.Screened according to different proportion, be shown in Table 4
Table 4
The preparation of 5.2 granules according to 4 pure medicinal extract of table and auxiliary material ratio, respectively by 70% ethanol system of medicinal extract and auxiliary material
Grain, particle fluidized drying in boiling drier, granulation.
The measure of 5.3 mouldabilities weighs the particle prepared, first crosses No.1 sieve, and after No. four sieves, collection can pass through one
Number sieve but can not by No. four sieve particles, weigh.Granular mass × 100% before granular mass/sieving after ratio of briquetting=sieving.
Score value=maximum score value × ratio of briquetting.It the results are shown in Table 5
The measure of the mouldability of table 5
| Prescription number | Quality g before sieving | Quality g after sieving | Ratio of briquetting (%) | Score value (15 points) |
| 1 | 1140g | 851g | 74.65 | 11.2 points |
| 2 | 1140g | 1080g | 94.74 | 14.21 points |
| 3 | 1140g | 795g | 69.74 | 10.46 points |
| 4 | 1140g | 884g | 77.54 | 11.63 points |
Conclusion：By the results contrast of table 5, the ratio of briquetting that prescription 2 is up to 94.74, and score value is 14.21 points, with other
There were significant differences for the ratio of briquetting of three groups of prescriptions.
5.4 particle proterties measure is shown in Table 6
The particle proterties of table 6 describe
| Prescription number | Particle | Hardness | Mouthfeel | Caking | Color |
| 1 | Uneven, coarse granule is more | It is slightly hard | Bitter | It is few | Taupe brown |
| 2 | Uniformly | It is moderate | Sweet taste is moderate | Nothing | Taupe brown |
| 3 | It is slightly uneven | Hand is pinched i.e. broken | Inclined sweet tea | Seldom | Brown color |
| 4 | Uniformly | It is slightly hard | Bitter | Seldom | Taupe brown |
The hygroscopicity measure of 5.5 particles
Proportioning according to prescription 1-4 weighs particle, puts in 30 DEG C of baking ovens, and bottom is placed with to the drier of NaCl saturated solutions
In be put into NaCl saturated solutions surely until shape NaCl supersaturated solutions, now the relative humidity in drier is 75%.Treat that 48 is small
When after weigh, calculate Moisture percentage.
Weight × 100% before Moisture percentage %=(weight before weight-moisture absorption after moisture absorption) ÷ moisture absorptions
The particle hygroscopicity of table 7 determines
| Prescription number | Particle weight/g before moisture absorption | Particle weight/g after moisture absorption | Moisture percentage (%) |
| 1 | 851g | 921g | 8.23 |
| 2 | 1080g | 1120g | 3.70 |
| 3 | 795g | 851g | 7.04 |
| 4 | 884g | 946g | 7.01 |
As a result：Show that the hydroscopicity of prescription number 2 is minimum by the hygroscopicity measurement result of table 7.
5.6 discuss
Chinese medical concrete generally has a stronger hygroscopicity, therefore directly pelletizes and acquire a certain degree of difficulty, in order to reduce its hygroscopicity
It is easy to pelletize, need to typically adds auxiliary material and be mixed with, but how much the ratio of auxiliary material also directly influences ratio of briquetting, the character of particle
And hydroscopicity, show that the optimal proportion of medicinal extract, sucrose and dextrin is 1 by the experiment：1.32：0.68, manufactured of the ratio
Grain ratio of briquetting is high, character is good and hydroscopicity is low, contributes to the stability for dispensing and storing.
Following embodiments can realize the effect of above-mentioned experimental example.
Embodiment
Embodiment 1
Take the Radix Isatidis of 1/3 amount and the capsule of weeping forsythia of 1/3 amount to clean, dry respectively, crushed 80 mesh sieves with high speed disintegrator and obtain
Fine powder；Radix scrophulariae and cicada slough are cleaned respectively, dried, crushed 80 mesh sieves with high speed disintegrator and obtain fine powder；By the plate of remaining 2/3 amount
Blue root is cleaned, and is boiled with the decocting of 8 times of amounts secondary, 2 hours first times, second 1.5 hours, merges decocting liquid twice, filtration, filtrate
It is 1.15-1.18 to be concentrated into 80 DEG C and survey relative densities, adds ethanol to make alcohol content up to 65%, stands, and takes supernatant recovery ethanol, and
It is concentrated into 80 DEG C and surveys the clear cream A that relative density is 1.25-1.30；The capsule of weeping forsythia of remainder 2/3 is cleaned with clear water, adds the water of 8 times of amounts
Decoct secondary, 2 hours for the first time, second 1.5 hours, merge decocting liquid twice, filtering, filtrate centrifuges, 3000rpm from
The heart, separates supernatant, and water bath method is concentrated into 1.25-1.30 medicinal extract B；Great burdock achene and peppermint are put in extractor, add 8 times of amounts
Water, 3 days laggard water-filling steam distillations are soaked, timing distillation 3 hours, collect volatile oil C since boiling；By great burdock achene and peppermint
The dregs of a decoction add 6 times of amount water of crude drug, decoct 1 hour and release decoction, 80 mesh screens, obtain filtrate D；By dandelion, moutan bark and
The indigo naturalis that point three guarantees are wrapped with calico adds 8 times of amount decoctings to boil twice, 1 hour every time, merges decocting liquid twice, filtration, filtrate with it is upper
State great burdock achene and peppermint filtrate D merges, be well mixed, be concentrated into 50 DEG C of heat and survey the clear cream E that relative density is 1.35~1.40；Will
Clear cream A, medicinal extract B, volatile oil C and clear cream E are stirred uniformly with homogenizer, add Radix Isatidis, the capsule of weeping forsythia, radix scrophulariae and cicada
Slough off fine powder and medicinal extract is mixed evenly to obtain, add 70% alcohol granulation of sucrose 500g, dextrin 260g, particle is in fluidized drying
Fluidized drying in machine, is made particle 1080g, and packing specification is 3g/ bags.Instructions of taking：Each taking 1.5g within one-year-old, one-year-old five
Year each taking 3g, takes 4.5g for more than five years old, 2 times a day.
Embodiment 2
Take the Radix Isatidis of 1/3 amount and the capsule of weeping forsythia of 1/3 amount to clean, dry respectively, crushed 80 mesh sieves with high speed disintegrator and obtain
Fine powder；Radix scrophulariae and cicada slough are cleaned respectively, dried, crushed 80 mesh sieves with high speed disintegrator and obtain fine powder；By the plate of remaining 2/3 amount
Blue root is cleaned, and is boiled with the decocting of 8 times of amounts secondary, 2 hours first times, second 1.5 hours, merges decocting liquid twice, filtration, filtrate
It is 1.15-1.18 to be concentrated into 80 DEG C and survey relative densities, adds ethanol to make alcohol content up to 65%, stands, and takes supernatant recovery ethanol, and
It is concentrated into 80 DEG C and surveys the clear cream A that relative density is 1.25-1.30；The capsule of weeping forsythia of remainder 2/3 is cleaned with clear water, adds the water of 8 times of amounts
Decoct secondary, 2 hours for the first time, second 1.5 hours, merge decocting liquid twice, filtering, filtrate centrifuges, 3000rpm from
The heart, separates supernatant, and water bath method is concentrated into 1.25-1.30 medicinal extract B；Great burdock achene and peppermint are put in extractor, add 8 times of amounts
Water, 3 days laggard water-filling steam distillations are soaked, timing distillation 3 hours, collect volatile oil C since boiling；By great burdock achene and peppermint
The dregs of a decoction add 6 times of amount water of crude drug, decoct 1 hour and release decoction, 80 mesh screens, obtain filtrate D；By dandelion, moutan bark and
The indigo naturalis that point three guarantees are wrapped with calico adds 8 times of amount decoctings to boil twice, 1 hour every time, merges decocting liquid twice, filtration, filtrate with it is upper
State great burdock achene and peppermint filtrate D merges, be well mixed, be concentrated into 50 DEG C of heat and survey the clear cream E that relative density is 1.35~1.40；Will
Clear cream A, medicinal extract B, volatile oil C and clear cream E are stirred uniformly with homogenizer, add Radix Isatidis, the capsule of weeping forsythia, radix scrophulariae and cicada
Slough off fine powder and medicinal extract is mixed evenly to obtain, add 70% alcohol granulation of sucrose 500g, dextrin 260g, particle is in fluidized drying
Fluidized drying in machine, is made particle 1090g, and packing specification is 3g/ bags.Instructions of taking：Each taking 1.5g within one-year-old, one-year-old five
Year each taking 3g, takes 4.5g for more than five years old, 2 times a day.
Embodiment 3
Take the Radix Isatidis of 1/3 amount and the capsule of weeping forsythia of 1/3 amount to clean, dry respectively, crushed 80 mesh sieves with high speed disintegrator and obtain
Fine powder；Radix scrophulariae and cicada slough are cleaned respectively, dried, crushed 80 mesh sieves with high speed disintegrator and obtain fine powder；By the plate of remaining 2/3 amount
Blue root is cleaned, and is boiled with the decocting of 8 times of amounts secondary, 2 hours first times, second 1.5 hours, merges decocting liquid twice, filtration, filtrate
It is 1.15-1.18 to be concentrated into 80 DEG C and survey relative densities, adds ethanol to make alcohol content up to 65%, stands, and takes supernatant recovery ethanol, and
It is concentrated into 80 DEG C and surveys the clear cream A that relative density is 1.25-1.30；The capsule of weeping forsythia of remainder 2/3 is cleaned with clear water, adds the water of 8 times of amounts
Decoct secondary, 2 hours for the first time, second 1.5 hours, merge decocting liquid twice, filtering, filtrate centrifuges, 3000rpm from
The heart, separates supernatant, and water bath method is concentrated into 1.25-1.30 medicinal extract B；Great burdock achene and peppermint are put in extractor, add 8 times of amounts
Water, 3 days laggard water-filling steam distillations are soaked, timing distillation 3 hours, collect volatile oil C since boiling；By great burdock achene and peppermint
The dregs of a decoction add 6 times of amount water of crude drug, decoct 1 hour and release decoction, 80 mesh screens, obtain filtrate D；By dandelion, moutan bark and
The indigo naturalis that point three guarantees are wrapped with calico adds 8 times of amount decoctings to boil twice, 1 hour every time, merges decocting liquid twice, filtration, filtrate with it is upper
State great burdock achene and peppermint filtrate D merges, be well mixed, be concentrated into 50 DEG C of heat and survey the clear cream E that relative density is 1.35~1.40；Will
Clear cream A, medicinal extract B, volatile oil C and clear cream E are stirred uniformly with homogenizer, add Radix Isatidis, the capsule of weeping forsythia, radix scrophulariae and cicada
Slough off fine powder and medicinal extract is mixed evenly to obtain, add 70% alcohol granulation of sucrose 500g, dextrin 260g, particle is in fluidized drying
Fluidized drying in machine, is made particle 1060g, and packing specification is 3g/ bags.Instructions of taking：Each taking 1.5g within one-year-old, one-year-old five
Year each taking 3g, takes 4.5g for more than five years old, 2 times a day.
Embodiment 4
Take the Radix Isatidis of 1/3 amount and the capsule of weeping forsythia of 1/3 amount to clean, dry respectively, crushed 80 mesh sieves with high speed disintegrator and obtain
Fine powder；Radix scrophulariae and cicada slough are cleaned respectively, dried, crushed 80 mesh sieves with high speed disintegrator and obtain fine powder；By the plate of remaining 2/3 amount
Blue root is cleaned, and is boiled with the decocting of 6 times of amounts secondary, 2.3 hours first times, second 1.2 hours, is merged decocting liquid twice, filtered, filter
It is 1.15-1.18 that liquid, which is concentrated into 90 DEG C and surveys relative densities, adds ethanol to make alcohol content up to 65%, stands, and takes supernatant recovery ethanol,
And it is concentrated into 70 DEG C and surveys the clear cream A that relative density is 1.25-1.30；By remainder 2/3 the capsule of weeping forsythia cleaned with clear water, add 10 times amount
Decocting is boiled secondary, 1.7 hours first times, second 1.8 hours, merges decocting liquid twice, filtering, and filtrate centrifuges, 3000rpm
Centrifugation, separates supernatant, and water bath method is concentrated into 1.25-1.30 medicinal extract B；Great burdock achene and peppermint are put in extractor, add 7 times
Water is measured, soaks 4 days laggard water-filling steam distillations, timing distillation 1.7 hours, collect volatile oil C since boiling；By great burdock achene and
The peppermint dregs of a decoction add 4 times of amount water of crude drug, decoct 1.3 hours and release decoction, 80 mesh screens, obtain filtrate D；By dandelion, male
The root bark of tree peony and the indigo naturalis for dividing three guarantees to be wrapped with calico add 10 times of amount decoctings to boil twice, 0.7 hour every time, merge decocting liquid twice, filter,
Filtrate merges with above-mentioned great burdock achene and peppermint filtrate D, is well mixed, and it is 1.35~1.40 to be concentrated into 55 DEG C of heat and survey relative density
Clear cream E；Clear cream A, medicinal extract B, volatile oil C and clear cream E are stirred uniformly with homogenizer, add Radix Isatidis, the capsule of weeping forsythia,
Medicinal extract is mixed evenly to obtain in radix scrophulariae and cicada slough fine powder, adds 70% alcohol granulation of sucrose 420g, dextrin 340g, particle in
Fluidized drying in boiling drier, is made particle 1080g, and packing specification is 3g/ bags.Instructions of taking：Within one-year-old each taking
1.5g, each taking 3g, 4.5g is taken within more than five years old, 2 times a day within one-year-old five years old.
Embodiment 5
Take the Radix Isatidis of 1/3 amount and the capsule of weeping forsythia of 1/3 amount to clean, dry respectively, crush to obtain fine powder；Radix scrophulariae and cicada slough are distinguished
Clean, drying, crush to obtain fine powder；The Radix Isatidis of remaining 2/3 amount is cleaned, is boiled with the decoctings of 10 times of amounts secondary, first time 1.7 is small
When, second 1.8 hours, merge decocting liquid twice, filtration, it is 1.15-1.18 that filtrate, which is concentrated into 70 DEG C and surveys relative density, adds ethanol
Alcohol content is set to stand up to 65%, take supernatant to reclaim ethanol, and be concentrated into 90 DEG C and survey the clear cream that relative density is 1.25-1.30
A；The capsule of weeping forsythia of remainder 2/3 is cleaned with clear water, adds the decocting of 6 times of amounts to boil secondary, 2.3 hours first times, second 1.2 hours,
Merge decocting liquid twice, filtering, filtrate centrifuges, and 3000rpm centrifugations, separates supernatant, water bath method is concentrated into 1.25-1.30
Medicinal extract B；Great burdock achene and peppermint are put in extractor, adds 10 times of amount water, soaks 2 days laggard water-filling steam distillations, opened from boiling
Beginning timing is distilled 4 hours, collects volatile oil C；Great burdock achene and the peppermint dregs of a decoction are added into 4 times of amount water of crude drug, decocts 1.3 hours and puts
Go out decoction, 80 mesh screens, obtain filtrate D；Dandelion, moutan bark and the indigo naturalis of dividing three guarantees to be wrapped with calico are added into 10 times of amount decoctings
Boil twice, 0.7 hour every time, merge decocting liquid twice, filtration, filtrate merges with above-mentioned great burdock achene and peppermint filtrate D, and mixing is equal
It is even, it is concentrated into 45 DEG C of heat and surveys the clear cream E that relative density is 1.35~1.40；Clear cream A, medicinal extract B, volatile oil C and clear cream E is high
Fast mixer is stirred uniformly, adds Radix Isatidis, the capsule of weeping forsythia, radix scrophulariae and cicada slough fine powder and medicinal extract is mixed evenly to obtain, then add
Enter 70% alcohol granulation of sucrose 600g, dextrin 160g, particle fluidized drying in boiling drier, particle 1090g is made, wrap
Dress specification is 3g/ bags.Instructions of taking：Each taking 1.5g within one-year-old, each taking 3g, 4.5g is taken within more than five years old within one-year-old five years old, one
Day 2 times.
Embodiment 6
Take the Radix Isatidis of 1/3 amount and the capsule of weeping forsythia of 1/3 amount to clean, dry respectively, crushed 80 mesh sieves with high speed disintegrator and obtain
Fine powder；Radix scrophulariae and cicada slough are cleaned respectively, dried, crushed 80 mesh sieves with high speed disintegrator and obtain fine powder；By the plate of remaining 2/3 amount
Blue root is cleaned, and is boiled with the decocting of 6 times of amounts secondary, 2.3 hours first times, second 1.2 hours, is merged decocting liquid twice, filtered, filter
It is 1.15-1.18 that liquid, which is concentrated into 90 DEG C and surveys relative densities, adds ethanol to make alcohol content up to 65%, stands, and takes supernatant recovery ethanol,
And it is concentrated into 70 DEG C and surveys the clear cream A that relative density is 1.25-1.30；By remainder 2/3 the capsule of weeping forsythia cleaned with clear water, add 10 times amount
Decocting is boiled secondary, 1.7 hours first times, second 1.8 hours, merges decocting liquid twice, filtering, and filtrate centrifuges, 3000rpm
Centrifugation, separates supernatant, and water bath method is concentrated into 1.25-1.30 medicinal extract B；Great burdock achene and peppermint are put in extractor, add 7 times
Water is measured, soaks 4 days laggard water-filling steam distillations, timing distillation 1.7 hours, collect volatile oil C since boiling；By great burdock achene and
The peppermint dregs of a decoction add 4 times of amount water of crude drug, decoct 1.3 hours and release decoction, 80 mesh screens, obtain filtrate D；By dandelion, male
The root bark of tree peony and the indigo naturalis for dividing three guarantees to be wrapped with calico add 10 times of amount decoctings to boil twice, 0.7 hour every time, merge decocting liquid twice, filter,
Filtrate merges with above-mentioned great burdock achene and peppermint filtrate D, is well mixed, and it is 1.35~1.40 to be concentrated into 55 DEG C of heat and survey relative density
Clear cream E；Clear cream A, medicinal extract B, volatile oil C and clear cream E are stirred uniformly with homogenizer, add Radix Isatidis, the capsule of weeping forsythia,
Medicinal extract is mixed evenly to obtain in radix scrophulariae and cicada slough fine powder, adds 70% alcohol granulation of sucrose 550g, dextrin 210g, particle in
Fluidized drying in boiling drier, is made particle 1060g, and packing specification is 3g/ bags.Instructions of taking：Within one-year-old each taking
1.5g, each taking 3g, 4.5g is taken within more than five years old, 2 times a day within one-year-old five years old.
Claims (4)
1. a kind of Xiaoer Qingyan Granule, it is characterised in that the Xiaoer Qingyan Granule is made up of the following raw material medicine and preparation method：
The parts by weight of 100 parts by weight dandelion of radix scrophulariae, 100 parts by weight great burdock achene 60
The parts by weight of 150 parts by weight peppermint of indigo naturalis, 30 parts by weight cicada slough 30
The parts by weight of the 100 parts by weight capsule of weeping forsythia of Radix Isatidis, 100 parts by weight moutan bark 30；
Take the Radix Isatidis of 1/3 amount and the capsule of weeping forsythia of 1/3 amount to clean, dry respectively, crushed 80 mesh sieves with high speed disintegrator and obtain fine powder；
Radix scrophulariae and cicada slough are cleaned respectively, dried, crushed 80 mesh sieves with high speed disintegrator and obtain fine powder；By the Radix Isatidis of remaining 2/3 amount
Clean, boiled with the decocting of 8 times of amounts secondary, 2 hours first times, second 1.5 hours, merge decocting liquid twice, filtration, filtrate concentration
It is 1.15-1.18 to survey relative density to 80 DEG C, adds ethanol alcohol content is stood up to 65%, is taken supernatant to reclaim ethanol, and concentrate
The clear cream A that relative density is 1.25-1.30 is surveyed to 80 DEG C；The capsule of weeping forsythia of remainder 2/3 is cleaned with clear water, adds the decocting of 8 times of amounts to boil
It is secondary, 2 hours for the first time, second 1.5 hours, merge decocting liquid twice, filtering, filtrate centrifuges, 3000rpm centrifugations, point
From supernatant, water bath method is concentrated into 1.25-1.30 medicinal extract B；Great burdock achene and peppermint are put in extractor, add 8 times of amount water, leaching
3 days laggard water-filling steam distillations are steeped, timing distillation 3 hours, collect volatile oil C since boiling；By great burdock achene and the peppermint dregs of a decoction
6 times of amount water of crude drug are added, decocts 1 hour and releases decoction, 80 mesh screens, obtain filtrate D；By dandelion, moutan bark and points three
The indigo naturalis that bag is wrapped with calico adds 8 times of amount decoctings to boil twice, 1 hour every time, merges decocting liquid twice, filtration, filtrate and above-mentioned ox
Burdock and peppermint filtrate D merge, and are well mixed, and are concentrated into 50 DEG C of heat and survey the clear cream E that relative density is 1.35~1.40；By clear cream
A, medicinal extract B, volatile oil C and clear cream E are stirred uniformly with homogenizer, and it is thin to add Radix Isatidis, the capsule of weeping forsythia, radix scrophulariae and cicada slough
Medicinal extract is mixed evenly to obtain in powder, adds the parts by weight of sucrose 500,70% alcohol granulation of the parts by weight of dextrin 260, particle is in boiling
Fluidized drying in drying machine is risen to produce.
2. Xiaoer Qingyan Granule as claimed in claim 1, it is characterised in that the Xiaoer Qingyan Granule is by the following raw material medicine and system
Preparation Method is made：
The parts by weight are using g as unit of account；
Bulk drug forms：
Radix scrophulariae 100g dandelion 100g great burdock achenes 60g
Indigo naturalis 150g peppermint 30g cicada sloughs 30g
Radix Isatidis 100g capsule of weeping forsythia 100g moutan barks 30g；
Preparation method is：
Take the Radix Isatidis of 1/3 amount and the capsule of weeping forsythia of 1/3 amount to clean, dry respectively, crushed 80 mesh sieves with high speed disintegrator and obtain fine powder；
Radix scrophulariae and cicada slough are cleaned respectively, dried, crushed 80 mesh sieves with high speed disintegrator and obtain fine powder；By the Radix Isatidis of remaining 2/3 amount
Clean, boiled with the decocting of 8 times of amounts secondary, 2 hours first times, second 1.5 hours, merge decocting liquid twice, filtration, filtrate concentration
It is 1.15-1.18 to survey relative density to 80 DEG C, adds ethanol alcohol content is stood up to 65%, is taken supernatant to reclaim ethanol, and concentrate
The clear cream A that relative density is 1.25-1.30 is surveyed to 80 DEG C；The capsule of weeping forsythia of remainder 2/3 is cleaned with clear water, adds the decocting of 8 times of amounts to boil
It is secondary, 2 hours for the first time, second 1.5 hours, merge decocting liquid twice, filtering, filtrate centrifuges, 3000rpm centrifugations, point
From supernatant, water bath method is concentrated into 1.25-1.30 medicinal extract B；Great burdock achene and peppermint are put in extractor, add 8 times of amount water, leaching
3 days laggard water-filling steam distillations are steeped, timing distillation 3 hours, collect volatile oil C since boiling；By great burdock achene and the peppermint dregs of a decoction
6 times of amount water of crude drug are added, decocts 1 hour and releases decoction, 80 mesh screens, obtain filtrate D；By dandelion, moutan bark and points three
The indigo naturalis that bag is wrapped with calico adds 8 times of amount decoctings to boil twice, 1 hour every time, merges decocting liquid twice, filtration, filtrate and above-mentioned ox
Burdock and peppermint filtrate D merge, and are well mixed, and are concentrated into 50 DEG C of heat and survey the clear cream E that relative density is 1.35~1.40；By clear cream
A, medicinal extract B, volatile oil C and clear cream E are stirred uniformly with homogenizer, and it is thin to add Radix Isatidis, the capsule of weeping forsythia, radix scrophulariae and cicada slough
Medicinal extract is mixed evenly to obtain in powder, adds 70% alcohol granulation of sucrose 500g, dextrin 260g, particle is in boiling drier
Fluidized drying, is made particle 1080g, and packing specification is 3g/ bags.
3. Xiaoer Qingyan Granule as claimed in claim 1 or 2, it is characterised in that the indigo naturalis is to decoct a drug wrapped.
4. Xiaoer Qingyan Granule as claimed in claim 1 or 2 is preparing fever and headache, cough caused by treatment treating cold due to wind-heat
Sound of coughing is mute or the medicine of abscess of throat in application.
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| CN1365796A (en) * | 2001-01-18 | 2002-08-28 | 杨孟君 | Nano medicine 'Xiaoer Qingyan' and its preparing process |
| CN104173571A (en) * | 2014-08-28 | 2014-12-03 | 海南葫芦娃制药有限公司 | Pediatric throat-heat-clearing granule and preparation method thereof |
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Effective date of registration: 20191211 Address after: 064400 No. 2966, modern equipment manufacturing industry cluster, Qian'an City, Tangshan City, Hebei Province Patentee after: Hebei Baishan Pharmaceutical Co.,Ltd. Address before: 063000 Hebei Province, Tangshan City Road North North West Road No. 18 Patentee before: Han Zhiqiang |
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Denomination of invention: The invention relates to a child Qingyan granule and a preparation method thereof Effective date of registration: 20210113 Granted publication date: 20180309 Pledgee: Bank of Cangzhou Limited by Share Ltd. Tangshan branch Pledgor: Hebei Baishan Pharmaceutical Co.,Ltd. Registration number: Y2021980000332 |
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Denomination of invention: A kind of Xiaoer Qingyan Granule and its preparation method Effective date of registration: 20230106 Granted publication date: 20180309 Pledgee: Bank of Cangzhou Limited by Share Ltd. Tangshan branch Pledgor: Hebei Baishan Pharmaceutical Co.,Ltd. Registration number: Y2023980030509 |
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Denomination of invention: A pediatric Qingyan granule and its preparation method Effective date of registration: 20231222 Granted publication date: 20180309 Pledgee: Bank of Cangzhou Limited by Share Ltd. Tangshan branch Pledgor: Hebei Baishan Pharmaceutical Co.,Ltd. Registration number: Y2023110000547 |
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