CN104940303A - Method for preparing pudilan anti-inflammation capsules - Google Patents
Method for preparing pudilan anti-inflammation capsules Download PDFInfo
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- CN104940303A CN104940303A CN201510358967.1A CN201510358967A CN104940303A CN 104940303 A CN104940303 A CN 104940303A CN 201510358967 A CN201510358967 A CN 201510358967A CN 104940303 A CN104940303 A CN 104940303A
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Abstract
The invention discloses a method for preparing pudilan anti-inflammation capsules. The method is characterized in that a dust-free superfine grinding technology is adopted for smashing radix scutellariae and a mixed extract, the loss ratio is controlled within 5%; a computer temperature control technology is adopted for temperature control, and the temperature range is controlled to be 70+/-2 DEG C. The prepared pudilan anti-inflammation capsule preparations have small inter-batch quality differences, and the content of baicalin in finished products is basically stabilized between 27.0 mg and 31.0 g per capsule.
Description
Technical field
The present invention relates to the preparation method of the blue antiphlogistic capsule in a kind of Pu ground.
Background technology
The blue antiphlogistic capsule in Pu ground is made up of Radix Scutellariae, Herba Taraxaci, Herba Corydalis Bungeanae, Radix Isatidis four Chinese medicine.There is heat-clearing and toxic substances removing, effect of anti-inflammation detumescence.For furuncle and phyma, pharyngitis, tonsillitis.In side, Radix Scutellariae nature and flavor are bitter, cold, and have heat clearing and damp drying, the effects such as eliminating fire and detoxication are monarch drug; Herba Taraxaci nature and flavor are bitter, sweet, cold, return liver, stomach warp, have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, effect of inducing diuresis for treating stranguria syndrome; Herba Corydalis Bungeanae acrid in the mouth, hardship, cold in nature.There is heat-clearing and toxic substances removing, the function of removing heat from blood detumescence.For carbuncle furuncle, the diseases such as anemopyretic cold; Radix Isatidis nature and flavor are bitter, cold, have heat-clearing and toxic substances removing, the function of removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, erysipelas, the diseases such as carbuncle; Herba Taraxaci, Herba Corydalis Bungeanae, Radix Isatidis are ministerial drug altogether.All medicines share, and play heat-clearing and toxic substances removing altogether, the merit of anti-inflammation detumescence.
Roughly, product criticizes a problem that quality comparison in difference is large to preparation technology's ubiquity preparation technology of Chinese patent medicine, thus the minimum content limit of the formulation also major control main pharmacodynamics composition of quality standard.
Micronizing is as a kind of brand new technical means, and the experimental results shows, and Chinese crude drug is after micronizing, and the consumption of Chinese medicine ultramicro decoction piece can reduce to 1/3-1/2 of prepared slices of Chinese crude drugs quantity, substantially can guarantee that its pharmacological action is constant.This may have two reasons, and one is that effective ingredient stripping increases, and two is that grain size of micropowder is many by gastrointestinal absorption.Due to the progress of science and technology and the innovation of engineering equipment technology, make dustless micronizing become possibility, dustless micronizing can greatly reduce medical material loss, also can greatly reduce the probability of environmental pollution.
The present invention adopts dustless superfine communication technique and computer temperature control dry technology, can greatly improve product process level of control, in conjunction with control technology in the middle of effective, thoroughly solve Chinese patent medicine and criticize a quality and differ greatly, instability, affects the problem of patient medication stability.Between the blue antiphlogistic capsule preparation in Pu ground prepared has batch, mass discrepancy is little, and in finished product, content of baicalin is basically stable between 27.0mg-31.0mg/ grain.
Summary of the invention
The angle that the object of the invention is to improve from micronizing drug effect is set about, and provides a kind of for promoting blood circulation and breaking stagnation, the ultrafine powder traditional Chinese medicine compositions of eliminating mass of stimulating the menstrual flow; Meanwhile, the preparation method of this Chinese medicine composition is provided.
The present invention is achieved through the following technical solutions:
Prescription quality compares: Radix Scutellariae 3 parts, Herba Taraxaci 8 parts, Herba Corydalis Bungeanae 2 parts, Radix Isatidis 3 parts.Preparation process is as follows:
(1) Radix Scutellariae 0.55 part, dustless micronizing to fineness is 10-25 μm, for subsequent use;
(2) all the other Radix Scutellariae 60% ethanol extractions 2 times, first time 10 times amount water extraction 3h, second time 10 times amount water extraction 2h, filter, merging filtrate, decompression recycling ethanol to relative density is 1.20-1.24(60 DEG C) thick paste, for subsequent use;
(3) Herba Taraxaci, Herba Corydalis Bungeanae decocting in water 2 times, for the first time 10 times of water gagings, decoct 1h, and second time 8 times of water gagings, decoct 1h, filter, merging filtrate, for subsequent use;
(4) Radix Isatidis adds water, 90 DEG C of warm macerating 2 times, first time 10 times amount water temperatures leaching 1h, second time 8 times amount water temperatures leaching 1h, and filter, merging filtrate, adds step (3) Aqueous extracts, be evaporated to relative density 1.30-1.34(50 DEG C) thick paste;
(5) step (4) thick paste, adds step (2) alcohol extract condensed cream, step (1) Radix Scutellariae superfine powder, and computer temperature control drying under reduced pressure is to dry, and micronizing, mixing, subpackage, granulates.
Wherein, step (1) and step (5) micronizing adopt dustless superfine communication technique, within loss rate 5%; The computer temperature control dry technology that step (5) adopts, temperature controls at 70 ± 2 DEG C.
The blue antiphlogistic capsule preparation content of baicalin in Pu ground prepared is basically stable between 27.0mg-31.0mg/ grain.
The invention has the beneficial effects as follows: adopt dustless superfine communication technique and computer temperature control dry technology, can greatly improve product process level of control, in conjunction with control technology in the middle of effective, thoroughly solve Chinese patent medicine and criticize a quality and differ greatly, instability, affects the problem of patient medication stability.Between the blue antiphlogistic capsule preparation in Pu ground prepared has batch, mass discrepancy is little, and in finished product, content of baicalin is basically stable between 27.0mg-31.0mg/ grain.
detailed description of the invention:
embodiment 1
Radix Scutellariae 271g Herba Taraxaci 722g
Herba Corydalis Bungeanae 180g Radix Isatidis 271g
(1) Radix Scutellariae 150.5g, dustless micronizing to fineness is 10-25 μm, for subsequent use;
(2) all the other Radix Scutellariae 60% ethanol extractions 2 times, first time 10 times amount water extraction 3h, second time 10 times amount water extraction 2h, filter, merging filtrate, decompression recycling ethanol to relative density is 1.20-1.24(60 DEG C) thick paste, for subsequent use;
(3) Herba Taraxaci, Herba Corydalis Bungeanae decocting in water 2 times, for the first time 10 times of water gagings, decoct 1h, and second time 8 times of water gagings, decoct 1h, filter, merging filtrate, for subsequent use;
(4) Radix Isatidis adds water, 90 DEG C of warm macerating 2 times, first time 10 times amount water temperatures leaching 1h, second time 8 times amount water temperatures leaching 1h, and filter, merging filtrate, adds step (3) Aqueous extracts, be evaporated to relative density 1.30-1.34(50 DEG C) thick paste;
(5) step (4) thick paste, adds step (2) alcohol extract condensed cream, step (1) Radix Scutellariae superfine powder, and computer temperature control drying under reduced pressure is to dry, and dustless micronizing to fineness is 10-25 μm, mixing, and subpackage is granulated.Lot number 20141201.
embodiment 2
Lot number 20141202,20141203,20150101,20150102,20150103,20150104,20150201,20150202,20150203 is prepared with method.
embodiment 3
To above-mentioned ten batch samples, according to the content assaying method of quality standard, carried out content determination of Baicalin, result is as follows:
In finished product, content of baicalin is basically stable between 27.0mg-31.0mg/ grain.
Claims (9)
1. Pu ground blue antiphlogistic capsule a preparation method, prescription and mass ratio as follows: Radix Scutellariae 3 parts, Herba Taraxaci 8 parts, Herba Corydalis Bungeanae 2 parts, Radix Isatidis 3 parts.
2. preparation process is as follows:
Radix Scutellariae 0.55 part, dustless micronizing to fineness is 10-25 μm, for subsequent use.
3. all the other Radix Scutellariae 60% ethanol extractions 2 times, first time 10 times amount water extraction 3h, second time 10 times amount water extraction 2h, filter, merging filtrate, decompression recycling ethanol to relative density is 1.20-1.24(60 DEG C) thick paste, for subsequent use.
4. Herba Taraxaci, Herba Corydalis Bungeanae decocting in water 2 times, for the first time 10 times of water gagings, decoct 1h, and second time 8 times of water gagings, decoct 1h, filter, merging filtrate, for subsequent use.
5. Radix Isatidis adds water, 90 DEG C of warm macerating 2 times, first time 10 times amount water temperatures leaching 1h, second time 8 times amount water temperatures leaching 1h, and filter, merging filtrate, adds step (3) Aqueous extracts, be evaporated to relative density 1.30-1.34(50 DEG C) thick paste.
6. step (4) thick paste, adds step (2) alcohol extract condensed cream, step (1) Radix Scutellariae superfine powder, and computer temperature control drying under reduced pressure is to dry, and micronizing, mixing, subpackage, granulates.
7. preparation method according to claim 1, is characterized in that step (1) and step (5) micronizing adopt dustless superfine communication technique, within loss rate 5%.
8. preparation method according to claim 1, it is characterized in that the computer temperature control dry technology that step (5) adopts, temperature controls at 70 ± 2 DEG C.
9. preparation method according to claim 1, the blue antiphlogistic capsule preparation content of baicalin in the Pu prepared ground is basically stable between 27.0mg-31.0mg/ grain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510358967.1A CN104940303A (en) | 2015-06-26 | 2015-06-26 | Method for preparing pudilan anti-inflammation capsules |
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| CN201510358967.1A CN104940303A (en) | 2015-06-26 | 2015-06-26 | Method for preparing pudilan anti-inflammation capsules |
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| CN201510358967.1A Pending CN104940303A (en) | 2015-06-26 | 2015-06-26 | Method for preparing pudilan anti-inflammation capsules |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109718278A (en) * | 2017-10-27 | 2019-05-07 | 江苏颐海药业有限责任公司 | A method of Pudilan antiphlogistic capsule is prepared using microwave crushing |
| CN112206254A (en) * | 2020-11-25 | 2021-01-12 | 江苏颐海药业有限责任公司 | Preparation method of traditional Chinese medicine preparation for clearing heat, removing toxicity, resisting inflammation and diminishing swelling |
| CN117064939A (en) * | 2023-09-13 | 2023-11-17 | 广东心宝药业科技有限公司 | Pudi blue anti-inflammatory capsule and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883564A (en) * | 2005-06-21 | 2006-12-27 | 杨次龄 | Chinese medicinal capsule for treating inflammation and preparation process |
| CN101204424A (en) * | 2006-12-22 | 2008-06-25 | 天津中新药业集团股份有限公司 | Composite of traditional Chinese traditional medicine for clearing away heat and toxic, antiinflammatory, detumescence and preparation method thereof |
| CN102357124A (en) * | 2011-10-25 | 2012-02-22 | 江苏济川制药有限公司 | Chinese medicine combination with effects of detumescence and inflammatory resistance and preparation method thereof |
-
2015
- 2015-06-26 CN CN201510358967.1A patent/CN104940303A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883564A (en) * | 2005-06-21 | 2006-12-27 | 杨次龄 | Chinese medicinal capsule for treating inflammation and preparation process |
| CN101204424A (en) * | 2006-12-22 | 2008-06-25 | 天津中新药业集团股份有限公司 | Composite of traditional Chinese traditional medicine for clearing away heat and toxic, antiinflammatory, detumescence and preparation method thereof |
| CN102357124A (en) * | 2011-10-25 | 2012-02-22 | 江苏济川制药有限公司 | Chinese medicine combination with effects of detumescence and inflammatory resistance and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109718278A (en) * | 2017-10-27 | 2019-05-07 | 江苏颐海药业有限责任公司 | A method of Pudilan antiphlogistic capsule is prepared using microwave crushing |
| CN112206254A (en) * | 2020-11-25 | 2021-01-12 | 江苏颐海药业有限责任公司 | Preparation method of traditional Chinese medicine preparation for clearing heat, removing toxicity, resisting inflammation and diminishing swelling |
| CN117064939A (en) * | 2023-09-13 | 2023-11-17 | 广东心宝药业科技有限公司 | Pudi blue anti-inflammatory capsule and preparation method thereof |
| CN117064939B (en) * | 2023-09-13 | 2024-03-08 | 广东心宝药业科技有限公司 | Pudi blue anti-inflammatory capsule and preparation method thereof |
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Application publication date: 20150930 |
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