CN102614386A - Medicament for treating apoplexy and hemiplegia and preparation method - Google Patents
Medicament for treating apoplexy and hemiplegia and preparation method Download PDFInfo
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- CN102614386A CN102614386A CN201210113174XA CN201210113174A CN102614386A CN 102614386 A CN102614386 A CN 102614386A CN 201210113174X A CN201210113174X A CN 201210113174XA CN 201210113174 A CN201210113174 A CN 201210113174A CN 102614386 A CN102614386 A CN 102614386A
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Abstract
The invention relates to a preparation method of a traditional Chinese medicine, in particular to a medicament for treating apoplexy and hemiplegia and a preparation method. The preparation method comprises the following steps of: pulverizing the rest twenty-one herbs such as black snake apart from muskiness with a super micro pulverizer into fine powder of 200 meshes and mixing for 30 minutes; and grinding the muskiness, mixing and grinding with the fine powder, uniformly mixing, utilizing 20 g of refined honey for every 100 g of powder and adding water, mixing uniformly and then pressing into pills; and drying to obtain the medicament. Compared with an original process product, a process product has the advantages that: the difference in the content of an active ingredient paeoniflorin (C23H28O11) in each pill is 0.3 mg, the difference in dissolution time limit is 15 minutes, the bioavailability can be improved by 60 percent, the effect is obvious after process innovation and optimization, and the curative effect of the product is greatly improved.
Description
Technical field
The present invention relates to a kind of Chinese medicinal preparation method, specifically is a kind of medicine and method for preparing of treating apoplexy and hemiplegia.
Background technology
In the prior art, Moschus antithrombotic pill (water-honeyed pill) is documented in National Drug Administration's national drug standards, drug standard numbering: 2001ZFB0081, treatment apoplexy, hemiplegia, slurred speech, Light-headedness medicine-writing out a prescription is: Moschus 2g; Cornu Saigae Tataricae 5g; Radix Notoginseng 25g; Rhizoma Gastrodiae 25g; Scorpio 10g; Zaocys 50g; Flos Carthami 50g; Radix Rehmanniae 50g; Radix Et Rhizoma Rhei 25g; Radix Puerariae 50g; Rhizoma Chuanxiong 25g; Bombyx Batryticatus 25g; Hirudo (scalding) 25g; Radix Astragali 100g; Arisaema Cum Bile 25g; Pheretima 50g; Radix Paeoniae Rubra 50g; Radix Angelicae Sinensis 50g; Herba Siegesbeckiae 100g; Caulis Lonicerae 100g; Caulis Spatholobi 100g; Caulis Trachelospermi 100g.Function cures mainly: collateral dredging is invigorated blood circulation, the refreshment dissipating blood stasis.Be used for apoplexy, hemiplegia, slurred speech, Light-headedness etc.Usage and dosage: oral, one time 1 bag, 3 times on the one.Its preparation method is: above 22 flavors, and except that Moschus, all the other Zaocyss etc. 20 are ground into fine powder simply; The Moschus porphyrize, with above-mentioned fine powder facing-up, mixing, every 100g powder adds an amount of water pill with refined honey 20g, promptly gets.It is slow that its shortcoming is that the medicine that obtains of this technology dissolves the speed of loosing in vivo, and active ingredient should not discharge, thereby causes curative effect to reduce.
Summary of the invention
The objective of the invention is provides a kind of technological effect better a kind of medicine and method for preparing of treating apoplexy and hemiplegia to above-mentioned deficiency.
Technical solution of the present invention is: a kind of medicine and method for preparing of treating apoplexy and hemiplegia may further comprise the steps:
(1) raw material: Moschus 2g; Cornu Saigae Tataricae 5g; Radix Notoginseng 25g; Rhizoma Gastrodiae 25g; Scorpio 10g; Zaocys 50g; Flos Carthami 50g; Radix Rehmanniae 50g; Radix Et Rhizoma Rhei 25g; Radix Puerariae 50g; Rhizoma Chuanxiong 25g; Bombyx Batryticatus 25g; Hirudo (scalding) 25g; Radix Astragali 100g; Arisaema Cum Bile 25g; Pheretima 50g; Radix Paeoniae Rubra 50g; Radix Angelicae Sinensis 50g; Herba Siegesbeckiae 100g; Caulis Lonicerae 100g; Caulis Spatholobi 100g; Caulis Trachelospermi 100g.
(2) above 22 flavors, except that Moschus, all the other Zaocyss etc. 20 are ground into fine powder 200 orders with super micron mill, incorporation time 30 minutes simply; The Moschus porphyrize, with above-mentioned fine powder facing-up, mixing, every 100g powder is pressed into ball after adding the water mix homogeneously with refined honey 20g, and oven dry (60 ℃ of bake out temperatures) promptly gets.
Advantage of the present invention is: 1, the effective ingredient content processed of the present invention is high, dissolves the time of loosing and improves or guaranteed curative effect thereby shortened than traditional handicraft.Active ingredient is not decomposed in the middle of the preparation process, and shows that through pharmacodynamic study its medicine effective component content is at utmost kept, thereby has improved bioavailability of medicament, has remarkable advantages than former method.2, its Main Ingredients and Appearance peoniflorin of product (C of obtaining of handicraft product of the present invention and former handicraft product
23H
28O
11) every of content differs 0.3mg, dissolve scattered time limit can differ 15min, and bioavailability can improve 60%, and effect is obvious after the process innovation optimization, has improved the curative effect of product greatly.
To combine embodiment that embodiment of the present invention is described in further detail below.
The specific embodiment
Embodiment
A kind of medicine and method for preparing of treating apoplexy and hemiplegia may further comprise the steps:
(1) raw material: Moschus 2g; Cornu Saigae Tataricae 5g; Radix Notoginseng 25g; Rhizoma Gastrodiae 25g; Scorpio 10g; Zaocys 50g; Flos Carthami 50g; Radix Rehmanniae 50g; Radix Et Rhizoma Rhei 25g; Radix Puerariae 50g; Rhizoma Chuanxiong 25g; Bombyx Batryticatus 25g; Hirudo (scalding) 25g; Radix Astragali 100g; Arisaema Cum Bile 25g; Pheretima 50g; Radix Paeoniae Rubra 50g; Radix Angelicae Sinensis 50g; Herba Siegesbeckiae 100g; Caulis Lonicerae 100g; Caulis Spatholobi 100g; Caulis Trachelospermi 100g.
(2) above 22 flavors, except that Moschus, all the other Zaocyss etc. 20 are ground into fine powder 200 orders with super micron mill, incorporation time 30 minutes simply; The Moschus porphyrize, with above-mentioned fine powder facing-up, mixing, every 100g powder is pressed into ball after adding the water mix homogeneously with refined honey 20g, and oven dry (60 ℃ of bake out temperatures) promptly gets.
Experimental example
The process choice Orthogonal experiment results is:
The factor level table:
Orthogonal Experiment and Design table and result
Select optimum experimental condition to be by result of the test: grinding particle size 200 orders, incorporation time 30 minutes, 60 ℃ of bake out temperatures.
Claims (1)
1. method for preparing of treating apoplexy and hemiplegia medicine is characterized in that may further comprise the steps:
(1) raw material: Moschus 2g; Cornu Saigae Tataricae 5g; Radix Notoginseng 25g; Rhizoma Gastrodiae 25g; Scorpio 10g; Zaocys 50g; Flos Carthami 50g; Radix Rehmanniae 50g; Radix Et Rhizoma Rhei 25g; Radix Puerariae 50g; Rhizoma Chuanxiong 25g; Bombyx Batryticatus 25g; Scald Hirudo 25g; Radix Astragali 100g; Arisaema Cum Bile 25g; Pheretima 50g; Radix Paeoniae Rubra 50g; Radix Angelicae Sinensis 50g; Herba Siegesbeckiae 100g; Caulis Lonicerae 100g; Caulis Spatholobi 100g; Caulis Trachelospermi 100g;
(2) above 22 flavors, except that Moschus, all the other Zaocyss etc. 20 are ground into fine powder 200 orders with super micron mill, incorporation time 30 minutes simply; The Moschus porphyrize, with above-mentioned fine powder facing-up, mixing, every 100g powder is pressed into ball after adding the water mix homogeneously with refined honey 20g, and oven dry promptly gets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210113174XA CN102614386A (en) | 2012-04-17 | 2012-04-17 | Medicament for treating apoplexy and hemiplegia and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210113174XA CN102614386A (en) | 2012-04-17 | 2012-04-17 | Medicament for treating apoplexy and hemiplegia and preparation method |
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| CN102614386A true CN102614386A (en) | 2012-08-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210113174XA Pending CN102614386A (en) | 2012-04-17 | 2012-04-17 | Medicament for treating apoplexy and hemiplegia and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393757A (en) * | 2013-06-26 | 2013-11-20 | 郑奎生 | Traditional Chinese medicine decoction for treating radioactive brain damage |
| CN107296898A (en) * | 2017-04-13 | 2017-10-27 | 钓鱼台医药集团吉林天强制药股份有限公司 | Moschus Cyclandelate and preparation method thereof |
-
2012
- 2012-04-17 CN CN201210113174XA patent/CN102614386A/en active Pending
Non-Patent Citations (4)
| Title |
|---|
| 中华人民共和国卫生部药典委员会编: "《卫生部颁中药标准（成方制剂）第10册》", 31 December 1995 * |
| 张兆旺等: "《中药药剂学》", 31 January 2002, 中国中医药出版社 * |
| 李德成等: "中药超微粉碎技术在中药制剂中广泛应用的优越性", 《世界中医药》 * |
| 苏瑞强等: "超微粉碎技术提高六味地黄丸(水蜜丸)溶出度的研究", 《中国中药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393757A (en) * | 2013-06-26 | 2013-11-20 | 郑奎生 | Traditional Chinese medicine decoction for treating radioactive brain damage |
| CN107296898A (en) * | 2017-04-13 | 2017-10-27 | 钓鱼台医药集团吉林天强制药股份有限公司 | Moschus Cyclandelate and preparation method thereof |
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Application publication date: 20120801 |