CN104939098B - A kind of enhancing bone immunity, health food for locking calcium and preparation method thereof of replenishing the calcium - Google Patents
A kind of enhancing bone immunity, health food for locking calcium and preparation method thereof of replenishing the calcium Download PDFInfo
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Abstract
The present invention is suitable for nutrition and health care field, there is provided a kind of enhancing bone immunity, health food for locking calcium and preparation method thereof of replenishing the calcium, the health food includes the component of following percentage by weight：Colostrum 35 55%, first milk basic protein 0.5 5.15%, calcium 35 51.5%, vitamin D 0.03 0.10%, auxiliary material surplus.It is raw material that the present invention, which selects calcium carbonate, vitamin D, on the basis of replenishing the calcium, it is especially added with just milk basic protein, reach the effect for calcium of replenishing the calcium, lock, the ability that bone tissue active absorption calcium and ossein etc. make osteotrophy is improved, meanwhile, first milk basic protein and colostrum compatible use, the two can be cooperated, and play the effect of synergy.
Description
Technical field
The invention belongs to nutrition and health care field, more particularly to it is a kind of strengthen bone immunity, lock calcium of replenishing the calcium health food and
Its preparation method.
Background technology
Immunity is the defense mechanism of human body itself, and sound immune function shows as immune defense, immunological homeostasis, is immunized
The physiological function of the aspect of monitoring three, i.e. body identify and remove the tissue of itself aging to the anti-infection ability of sex pheromone
The ability of cell, and the ability that killing and removing abnormal sudden change cell, suppression malignant tumour are grown in vivo.The immunity of people
It is divided into two kinds of innate immunity and the adaptive immune power day after tomorrow.The power of immunity is the external table of human immune system's function quality
It is existing, it is directly related to the health of human body and the ability of resist the disease.World Health Organization's investigation display, the people that the whole world has 50% have
Hypoimmunity problem, it is necessary to which the fast area of strengthen immunity, particularly developed country and rhythm of life, hypoimmunity are asked
Topic is more prominent.The crowd of China's hypoimmunity is extensive, wherein especially in the majority with white collar, intellectual, Enterprises Leader.Someone
Shown in the health survey to National urban white collar elite in 2009, the white collar crowd in mainstream city has 76% to be in unhealthy shape
State.
Many reasons can cause immune system normally to play protective effect, in the case, easily cause bacterium, disease
Poison, fungi etc. infect, and most directly performance is exactly liable to illness, and the body of hypoimmunity is easy to infected or cancer stricken.Exempt from
Epidemic disease system can be generally divided into humoral immunity and cellular immunity.Humoral immunity relates generally to can be with various attack thing knots in human body
The antibody of conjunction, they are a kind of macro-molecular proteins, also referred to as immunoglobulin, including IgG, IgA, IgM and IgD, five kinds of IgE
Type.Cellular immunity relates generally to two major class cells：B cell and T cell, T cell are segmented into cd4 cell and cd8 cell again；
Functionally briefly, B cell can generate various antibody, and T cell can inherently kill or swallow into vivo each
Kind pathogen.
In the today advocated back to nature, pursue natural green product, people are thirsted for by adjusting dietary structure, Replacement Battalion
Foster material improves the general level of the health of itself and quality of life, achievees the purpose that health care, lengthens the life.Strengthen immunity currently on the market
Health food be roughly divided into four classes：
1. animal foremilk health food：Using animal foremilk as health food made of raw material, containing high-quality in animal foremilk
Albumen and immune protein, can improve immunity of organisms.
2. plant nutrient health products：Using natural or rare species as raw material, the health products of effective nutritional ingredient are extracted, such as
Albumen is extracted from soybean, nutrients is extracted from the plants such as red bean, black soya bean, ginkgo leaf.This kind of health products are not suitable for mostly
Virgin and pregnant woman eats.
3. rare animals and plants health products：Using rare Chinese medicine or there is tonic type of the animals and plants of medical value as primary raw material to protect
Strong product, such as ginseng, pilose antler, ganoderma lucidum, ginkgo.This kind of health products are generally adapted friend person in middle and old age and take, but are not appropriate for children
Take, pregnant woman also not take preferably.
4. vitamin and mineral health products：Auxotype health products using vitamin and mineral as main component, it is this kind of
Health products mainly contain vitamin and mineral.These nutrients are needed by human body, some easily lack, are not easy from common food
The enough amounts of middle intake, also just like special populations such as pregnant woman, wet nurse, children, it is necessary to increase dosage.
The content of the invention
It is an object of the invention to：There is provided a kind of enhancing bone immunity, the health food for lock calcium of replenishing the calcium, it is intended to solve existing
Strengthen immunity health food target user narrow range, the imperfect problem of enhancing effect has been immunized.
The enhancing bone immunity provided by the invention, the health food for lock calcium of replenishing the calcium include following percentage by weight into
Point：
The calcium can be calcium carbonate, milk calcium, calcium pantothenate, calcium lactate, calcium citrate, calcium acetate, amino acid chelated calcium,
One or more in the substantial equivalences such as calcium gluconate, Chinese holly edge tart apple acid calcium.The colostrum refers to that healthy cow is given a birth
Secreted milk within latter week.Contain a variety of growth factors, immunoglobulin, bioactivity peptide-binding proteins in colostrum
And the vitamin and trace element of needed by human body, its nutritive value are higher by several times to tens times of common cow's milk, and containing a large amount of
Immune factor and growth factor isoreactivity component, to improving the immunity of the human body, prevention disease there is uniqueness, while it
The dependence of body fight life element can also be reduced, any side effect will not be produced, at any time equal can effectively protect body
Health.The present invention is especially added with the first milk basic protein of new resource food of health ministry announcement（CBP）, first milk basic protein is
Using colostrum as raw material, through sterilization, degreasing, centrifugation, removal casein, α-lactalbumin, beta lactoglobulin, micro-filtration, surpass
The condensing protein that the molecular weight made of technique such as filter, freeze-drying are 1-30KD, is the rare egg not having in other dairy products
In vain, high, good absorbing is worth as small molecule concentrated alkaline nutrient protein.CBP can be done directly on bone cells, promote bone new
Old metabolism, promotes bone growth, repairs sclerotin, reaches comprehensive reparation and the regeneration effect of bone.Contain osteocalcin, bone in CBP
Fibronectin, bone bridge element（OPN）, bone morphogenetic protein（BMP）And alkaline phosphatase（ALP）Deng.Wherein, BMP and ALP is participated in
In each stage of bone metabolism, can induce the inside and outside film of bone and marrow stromal cell to be divided into osteoblast, have and strengthen the regeneration of bone bed
The effect of ability, the source of abundance is provided for the generation of immunocyte, can be with induced animal or human mesenchymal's cell differentiation
For skeletonization, cartilage, ligament, tendon and nerve fiber, ensure the strong of marrow peripheral tissues, avoid damaging and being invaded by germ
Attack, cause bone hypoimmunity；And osteocalcin can then help " to pack ", calcium constituent is synthesized by osteoblast and secreted in bone
Into bone, bone calcium is adjusted and maintained.Calcium is the essential trace elements of the human body, has important physiological function, can activate and increase
The immunocompetence of strong internal lymphokine, while be also the signal of interest transduction molecule of regulation and control immune cell function.Vitamin D
It is a kind of liposoluble vitamin, main Physiological Function is to adjust internal Ca,P metabolism, maintains plasma calcium, phosphorus horizontal, passes through promotion
The absorption of calcium and then adjusting different physiological roles.In addition, vitamin D also be used to reduce colon cancer, breast cancer and prostate cancer
Probability, also have humidification to immune system.Some researches show that when vitamin D deficiency, monocyte and macrophage open
Moving the ability of this natural immunity function will be obstructed.
Above-mentioned items component is commercially available.
The enhancing bone immunity, lock calcium of replenishing the calcium health food preparation method it is as follows：
1）Calcium, colostrum, first milk basic protein, vitamin D, auxiliary material are crushed respectively, sieves, obtains fine powder, it is spare.
2）The colostrum fine powder of formula rate, calcium fine powder are uniformly mixed in three-dimensional mixer, obtain mixed powder 1；Will be just
Milk basic protein fine powder, auxiliary material fine powder are uniformly mixed, and obtain mixed powder 2；By the vitamin D fine powder of recipe ratio row according to equal increments
Method mixes, and is finished until all mixed powders 2 are mixed, obtains mixed powder 3.
3）The adhesive necessarily matched is added into mixed powder 1（Such as HPC, HPMC, EC, PVP）Ethanol solution simultaneously stirs
Uniform softwood processed, softwood is sieved and is pelletized, obtains wet granular, then wet granular is dried certain time, is sieved after the dry particl of system whole
Grain, obtains dry particl thing.
4）By mixed powder 3 and step 3）In dry particl thing mixed according to equal increments method, until by all dry particl things
Mixing finishes, and obtains total mixture.
5）Granule, tablet or capsule etc. is made by the prior art according to the market demand in above-mentioned total mixture, packaging is
Obtain product of the present invention.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Motherland's medicine thinks " nourishing the bone of health elder generation ".Nourishing the bone can be construed to from the angle of motherland's medicine：It is QI invigorating, blood-nourishing, strong
Essence, zhuanggu, improve constitution so as to prolong life.In order to strengthen the immunity of body, improve associated such as insomnia, fatigue
With the sub-health state such as whole body discomfort, body is set to accomplish that all kinds of diseases and ailments are not invaded, nourishing the bone is top priority, and bone is not only people and other
The blood forming organ of mammal, or the cradle of various immunocytes, bone health could provide for the generation of immunocyte
Sufficient " raw material ".In order to solve market strengthen immunity health food target user's narrow range, ignore bone sub-health state
Caused by strengthen immunity effect unobvious the defects of, the present invention provides one kind containing colostrum, first milk basic protein, carbonic acid
Health foods of strengthen immunity of active ingredient such as calcium, vitamin D and preparation method thereof.
Embodiment 1：
The enhancing bone immunity, the health food for lock calcium of replenishing the calcium include the component of following percentage by weight：
The preparation process of health food in the present embodiment is as follows：
1）By calcium carbonate, colostrum, first milk basic protein, vitamin D, citric acid, orange flavor, Aspartame difference powder
Broken, sieving, obtains fine powder, spare.
2）The colostrum fine powder of formula rate, calcium carbonate fine powder are mixed into 30min in three-dimensional mixer；Obtain mixed powder 1；
The vitamin D fine powder of formula rate, Aspartame fine powder are mixed according to equal increments method, until all Aspartames is thin
Powder mixing finishes, and obtains mixed powder 2；First milk basic protein fine powder, citric acid fine powder, orange flavor fine powder are mixed with mixed powder 2
30min, obtains mixed powder 3.
3）10% PVP K30 ethanol solution is added into mixed powder 1 and stirs evenly softwood processed, softwood is sieved and is pelletized, is obtained
Wet granular, then wet granular is dried into certain time, sieving, whole grain after dry particl is made, obtains dry particl thing.
4）Mixed powder 3 is mixed with dry particl thing according to equal increments method, finishes, obtains until all dry particl things are mixed
Mixture 4, by mixture 4 and magnesium stearate mixing 10min, obtains total mixture.
5）Total mixture is placed in rotary tablet press, obtains tablet, is packed up to product of the present invention.
Embodiment 2：
The enhancing bone immunity, the health food for lock calcium of replenishing the calcium include the component of following percentage by weight：
The preparation process of health food in the present embodiment is as follows：
1）By calcium carbonate, colostrum, first milk basic protein, vitamin D, citric acid, lactic acid, orange flavor, Aspartame
Crush respectively, sieve, obtain fine powder, it is spare.
2）The colostrum fine powder of formula rate, calcium carbonate fine powder are mixed into 30min in three-dimensional mixer；Obtain mixed powder 1；
The vitamin D fine powder of formula rate, Aspartame fine powder are mixed according to equal increments method, until all Aspartames is thin
Powder mixing finishes, and obtains mixed powder 2；By first milk basic protein fine powder, citric acid fine powder, lactic acid fine powder, orange flavor fine powder with mixing
Close powder 2 and mix 30min, obtain mixed powder 3.
3）10% PVP K30 ethanol solution is added into mixed powder 1 and stirs evenly softwood processed, softwood is sieved and is pelletized, is obtained
Wet granular, then wet granular is dried into certain time, sieving, whole grain after dry particl is made, obtains dry particl thing.
4）Mixed powder 3 is mixed with dry particl thing according to equal increments method, finishes, obtains until all dry particl things are mixed
Mixture 4, by mixture 4 and magnesium stearate mixing 10min, obtains total mixture.
5）Total mixture is placed in rotary tablet press, obtains tablet, is packed up to product of the present invention.
Embodiment 3：
The enhancing bone immunity, the health food for lock calcium of replenishing the calcium include the component of following percentage by weight：
The preparation process of health food in the present embodiment is as follows：
1）Calcium carbonate, colostrum, first milk basic protein, vitamin D, citric acid are crushed respectively, sieves, obtains fine powder, it is standby
With.
2）The colostrum fine powder of formula rate, calcium carbonate fine powder are mixed into 30min in three-dimensional mixer；Obtain mixed powder 1；
By first milk basic protein fine powder, citric acid fine powder mixing 30min, mixed powder 2 is obtained after mixing；By the vitamin of formula rate
D fine powders are mixed according to equal increments method, are finished until all mixed powders 2 are mixed, are obtained mixed powder 3.
3）10% PVP K30 ethanol solution is added into mixed powder 1 and stirs evenly softwood processed, softwood is sieved and is pelletized, is obtained
Wet granular, then wet granular is dried into certain time, sieve after the dry particl of system, whole grain, obtain dry particl thing.
4）Mixed powder 3 is mixed with dry particl thing according to equal increments method, finishes, obtains until all dry particl things are mixed
Mixture.
5）Mixture obtained by step 4) is filled into capsule, is polished up to product of the present invention.
Strengthen immunity function test：
The health food that the embodiment 1, embodiment 2, embodiment 3 are provided carries out strengthen immunity animal function respectively
Experiment, i.e., carried out weight, internal organs/weight ratio measurement respectively（Thymus gland/weight ratio, spleen/weight ratio）, cellular immunity
Functional examination（Mouse spleen lymphocyte conversion test, delayed allergy experiment）, humoral immune function measure（Antibody tormation
Cell detection, serum hemolysin measure）And NK cytoactive detections evaluate immune function, three embodiments are pressed respectively
10 times of amounts of human body recommended dose prepare the gavage liquid of respective concentration with distilled water, and as experimental group, control group is filled with aqua sterilisa
Stomach, gavage amount are 20ml/kg.bw, once a day, continuous gavage 30 days.
Result of the test compares as follows：
1st, to the influence of rat body weight（It is shown in Table 1- tables 4）
Influence of the table 1 to mouse weight（Serum hemolysin, antibody-producting cell and delayed allergy measure group）
Known by table 1：Serum hemolysin, antibody-producting cell and delayed allergy measure group Analysis of variance, each reality
A group is applied compared with control group, difference that there are no significant（P>0.05）
Influence of the table 2 to mouse weight（Swallow chicken red blood cell group）
Analysis of variance, each embodiment group is compared with control group, difference that there are no significant（P>0.05）.
Influence of the table 3 to mouse weight（NK cytoactive detections turn measure group with leaching）
Analysis of variance, each embodiment group is compared with control group, difference that there are no significant（P>0.05）.
Influence of the table 4 to mouse weight（Carbonic clearance measure group）
Analysis of variance, each embodiment group is compared with control group, difference that there are no significant（P>0.05）.
2nd, to the influence of mice organs, weight ratio（It is shown in Table 5）
Influence of the table 5 to mice organs/weight ratio
Analysis of variance, each embodiment group is compared with control group, its internal organs/weight ratio, and thymus gland/weight ratio is without aobvious
Write sex differernce（P>0.05）.
3rd, cellular immune function is tested（Mouse spleen lymphocyte conversion test, mouse delayed allergy experiment）As a result
Deck watch is shown in Table 6 and table 7.
Table 6 is to mouse delayed allergy（DTH）Influence
Antigen attack after 24 it is small when, for each embodiment group compared with control group, its toes swelling has significant difference（P
＜ 0.05）.
The influence that table 7 converts mouse lymphocyte
| Group（mg/kg.bw） | Number of animals（Only） | Optical density difference（X±S） |
| Control group | 11 | 0.513±0.084 |
| Embodiment 1 | 11 | 0.639±0.101 |
| Embodiment 2 | 11 | 0.645±0.115 |
| Embodiment 3 | 11 | 0.633±0.103 |
For each embodiment group compared with control group, its optical density difference has significant difference（P ＜ 0.05）.
4th, humoral immune function measures（Antibody-producting cell detection and serum hemolysin measure）It the results are shown in Table 8- tables 10.
Influence of the table 8 to mice serum hemolytic antibody product and mouse antibodies cellulation
Each embodiment group is compared with control group, its antibody product and antibody-producting cell number there are no significant difference（P>
0.05）.
Influence of the table 9 to Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell ability
Each embodiment group is compared with control group, the phagocytic percentage of its peritoneal macrophage phagocytosis chicken red blood cell and phagocytosis
Index has significant difference（P ＜ 0.01）.
Influence of the table 10 to mouse carbonic clearance
| Group（mg/kg.bw） | Number of animals（Only） | Phagocytic index a（X±S） |
| Control group | 11 | 5.56±0.66 |
| Embodiment 1 | 11 | 6.46±0.73 |
| Embodiment 2 | 10 | 6.25±0.78 |
| Embodiment 3 | 10 | 6.43±0.80 |
For each embodiment group compared with control group, its phagocytic index a has significant difference（P ＜ 0.05）.
5th, NK cytoactive detections the results are shown in Table 11.
Influence of the table 11 to NK cells in mice activity
Each embodiment group is compared with control group, its NK cytoactives rate there are no significant difference（P ＞ 0.05）.
Shown according to above result of the test, the health food that the embodiment 1,2,3 provides is respectively provided with significant enhancing and exempts from
Epidemic disease power function.
Colostrum can suppress germ reproduction, be a kind of healthy functions that can strengthen body immunity, promote tissue growth
Food.It containing unique energy in addition to passing through the wide spectrum IgG antibody of placenta, also rich in the immune thing such as lactoferrin, lactalbumin
Matter, also has substantial amounts of growth factor and milk calcium, can promote infant's bone growth, and help physical function healthy development.Meanwhile
Colostrum is identified as being a kind of material for having bone anabolic action, finds wherein to have by substantial amounts of scientific experimentation and is somebody's turn to do
It is a kind of small molecule active albumen-first milk basic protein to act on major physiological active material（CBP）, it can be done directly on bone
Bone cell, promotion bone metabolism, promotes bone growth, repairs sclerotin, reaches comprehensive reparation and the regeneration effect of bone, carries
Processus styloideus radii immunity.But contents of the CBP in colostrum is only 4/10000ths, this is also to be immunized when why colostrum content is too low
The inapparent one of the major reasons of effect.It is raw material that the present invention, which selects calcium carbonate, vitamin D, on the basis of replenishing the calcium, is especially added
Add just milk basic protein, reach the effect for calcium of replenishing the calcium, lock, improve the energy that bone tissue active absorption calcium and ossein etc. make osteotrophy
Power, meanwhile, first milk basic protein and colostrum compatible use, the two can be cooperated, and play the effect of synergy, to bone and
Joint is protected comprehensively, ensures bone health, and the generation for endogenic immune cell provides raw material, and exogenous
Immune substance coordinates, and plays its strengthen immunity function to greatest extent.In addition, research is it has also been found that alkaline components specific to CBP
It is able to maintain that the stabilization of interior environment, avoids organismic internal environment by the invasion and attack of acidic materials and cause hypoimmunity.Meanwhile this hair
Bright is the food using colostrum as primary raw material, is a kind of very wide Immune-enhancing effect product of scope of application, and either children, green grass or young crops are few
Year, middle-aged and elderly people can take, it can be combined with the diet of people, for carrying out prevention in China and sending out early
Existing bone immunocompromised is of great significance.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement made within refreshing and principle etc., should all be included in the protection scope of the present invention.
Claims (1)
1. a kind of strengthen bone immunity, the preparation method for the health food for locking calcium of replenishing the calcium, it is characterised in that the health food bag
Include the component of following percentage by weight：
It is prepared as follows：
Calcium carbonate, colostrum, first milk basic protein, vitamin D, auxiliary material are crushed respectively, sieves, obtains fine powder, it is spare；
The colostrum fine powder of formula rate, calcium carbonate fine powder are uniformly mixed in three-dimensional mixer, obtain mixed powder 1；By colostrum
Basic protein fine powder, auxiliary material fine powder are uniformly mixed, and obtain mixed powder 2；By the vitamin D fine powder of formula rate according to equal increments method
Mixing, finishes until all mixed powders 2 are mixed, obtains mixed powder 3；
The adhesive ethanol solution necessarily matched is added into mixed powder 1 and stirs evenly softwood processed, softwood is sieved and is pelletized, is obtained
Wet granular, then wet granular is dried into certain time, whole grain of sieving after the dry particl of system, obtains dry particl thing；
Mixed powder 3 is mixed with dry particl thing according to equal increments method, is finished until all dry particl things are mixed, is obtained and always mix
Produce product.
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| CN105996049A (en) * | 2016-06-15 | 2016-10-12 | 天津天狮生物发展有限公司 | Child instant medicine for boosting immunity |
| CN114343187A (en) * | 2021-12-27 | 2022-04-15 | 北京康比特体育科技股份有限公司 | Health beverage containing collagen tripeptide and preparation method thereof |
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| CN102356877A (en) * | 2011-10-14 | 2012-02-22 | 李泼 | CBP calcium supplement electuary |
| CN102524407A (en) * | 2011-12-15 | 2012-07-04 | 广东汤臣倍健生物科技股份有限公司 | Immunity-enhancing cow colostrum calcium chewable tablet |
| CN102763729B (en) * | 2012-07-11 | 2013-09-04 | 南京苏邦生物技术有限公司 | Composite bovine colostrum powder for improving bone mineral density |
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